Gabriel M. Pagnotti, Ph.D.
Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2014 | SUNY Stony Brook University, Stony Brook, New York, US, Ph.D. in Biomedical Engineering |
| 2008 | University of South Florida, Tampa, Florida, US, M.S. in Biomedical Engineering |
| 2002 | University of Central Florida, Orlando, Florida, US, B.S. in Electrical Engineering |
Postgraduate Training
| 2016-2020 | Postgraduate Fellow, Endocrine/Hematology, Indiana University, Indianapolis, Indiana |
| 2014-2016 | Postdoctoral Associate, Biomedical Engineering, SUNY Stony Brook University, Stony Brook, New York |
| 2003-2005 | Post-Baccalaureate Studies, Molecular & Microbiology, University of Central Florida, Orlando, FL |
Experience & Service
Other Appointments/Responsibilities
Associate Director, Bone Disease Program of Texas, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present
Liaison to the XTREMECT II, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present
Maintenance and Oversight of Micro-Computed Tomography Equipment, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2020 - Present
Graduate Teaching Assistant, Introduction to Genetic Engineering, Stony Brook University, Stony Brook, NY, 2009 - 2010
Graduate Teaching Assistant, Introduction to Biomedical Engineering, Stony Brook University, Stony Brook, NY, 2009 - 2010
Systems Engineer, Electrical/ITS-Transportation Engineering, Gord and Associates, Inc, Tampa, FL, 2008 - 2009
Research Assistant, Molecular Parasitology, University of Central Florida, Tampa, FL, 2005 - 2006
Systems Engineer, Electrical/ITS-Transportation Engineering, MasTec North America, Inc./Atlas Traffic Management, Tampa, FL, 2004 - 2008
Institutional Committee Activities
Associate Member, Graduate School of Biomedical Sciences, 2024 - 2029
Member, Faculty Senate Extended Hours Taskforce, 2024 - Present
Co-Chair, FY25 DoIM Research Grand Rounds Subcommittee, 2024 - Present
Member, Executive Committee of the Faculty Senate, 2024 - Present
Chair, Faculty Senate Travel Subcommittee, 2023 - Present
Member, Faculty Senate Faculty Led Survey Subcommittee, 2023
Member, Department of Internal Medicine Research Committee, 2023 - Present
Member, Department of Internal Medicine Research Grand Rounds Subcommittee, 2023 - Present
Member, Academic Review Committee, 2022 - Present
Member, Junior Faculty Committee, 2022 - Present
Member, Faculty Senate, 2021 - Present
Honors & Awards
| 2021 | Lawrence Award, Bone Disease Program of Texas |
| 2019 | John Haddad Award, American Society for Bone and Mineral Research |
| 2018 | Clinical and Translational Science Kroenke 1st Place Award for Best Poster, Clinical and Translational Science |
| 2018 | Young Investigator Award, American Society for Bone and Mineral Research |
| 2015 | Best Presentation Post-Doctoral Spotlight Symposium, Stony Brook University |
| 2011 | American Society for Bone and Mineral Research Poster Award, American Society for Bone and Mineral Research |
| 2011 | Endocrinology Fellowship Forum, EFF/ADA Fellows Forum on Metabolic Bone Diseases |
| 2001 - 2002 | College of Engineering Dean's List, University of Central Florida |
| 1998 - 2002 | Florida Bright Future's Full Tuition Scholarship, University of Central Florida |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Chan, ME, Ashdown, C, Strait, L, Pasumarthy, S, Hassan, A, Crimarco, S, Singh, C, Patel, VS, Pagnotti, GM, Khan, O, Uzer, G, Rubin, CT. Low intensity mechanical signals promote proliferation in a cell-specific manner. Mechanobiology in Medicine 2(4), 2024. e-Pub 2024. PMID: 39717386.
- Plett PA, Chua HL, Wu T, Sampson CH, Guise TA, Wright L, Pagnotti GM, Feng H, Chin-Sinex H, Pike F, Cox GN, MacVittie TJ, Sandusky G, Orschell CM. Effect of age at time of irradiation, sex, genetic diversity, and granulopoietic cytokine radiomitigation on lifespan and lymphoma development in murine H-ARS survivors. Radiation Research 202(3):580-598, 2024. e-Pub 2024. PMID: 39099001.
- McGrath C, Little-Letsinger SE, Pagnotti GM, Sen B, Xie Z, Uzer G, Uzer GB, Zong X, Styner MA, Rubin J, Styner M. Diet-Stimulated Marrow Adiposity Fails to Worsen Early, Age-Related Bone Loss. Obesity Facts 17(2):145-157, 2024. e-Pub 2024. PMID: 38224679.
- Chan ME, Ashdown C, Strait L, Pasumarthy S, Hassan A, Crimarco S, Singh C, Patel VS, Pagnotti GM, Khan O, Uzer G, Rubin CT. Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields. Mechanobiology in Medicine, 2024. e-Pub 2024. PMID: 37461507.
- Fu J, Li S, Ma H, Yang J, Pagnotti GM, Brown LM, Weiss SJ, Mapara MY, Lentzsch S. The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease. Nat Commun 14(1):4271, 2023. e-Pub 2023. PMID: 37460553.
- Trivedi T, Manaa M, John S, Reiken S, Murthy S, Pagnotti GM, Dole NS, She Y, Suresh S, Hain BA, Regan J, Ofer R, Wright L, Robling A, Cao X, Alliston T, Marks AR, Waning DL, Mohammad KS, Guise TA. Zoledronic acid improves bone quality and muscle function in a high bone turnover state. bioRxiv, 2023. e-Pub 2023. PMID: 37333318.
- Pagnotti GM, Trivedi T, Wright LE, John SK, Murthy S, Pattyn RR, Willis MS, She Y, Suresh S, Thompson WR, Rubin CT, Mohammad KS, Guise TA. Low-Magnitude Mechanical Signals Combined with Zoledronic Acid Reduce Musculoskeletal Weakness and Adiposity in Estrogen-Deprived Mice. bioRxiv, 2023. e-Pub 2023. PMID: 36993656.
- Nagata Y, Miyagawa K, Ohata Y, Petrusca DN, Pagnotti GM, Mohammad KS, Guise TA, Windle JJ, David Roodman G, Kurihara N. Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease. J Cell Biochem 122(3-4):335-348, 2021. e-Pub 2021. PMID: 33107091.
- Yi X, Wright LE, Pagnotti GM, Uzer G, Powell KM, Wallace J, Sankar U, Rubin CT, Mohammad KS, Guise TA, Thompson WR. Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity. Bone Research 8(1), 2020. e-Pub 2020. PMID: 33298883.
- Pagnotti GM, Haider A, Yang A, Cottell KE, Tuppo CM, Tong KY, Pryor AD, Rubin CT, Chan ME. Postural Stability in Obese Preoperative Bariatric Patients Using Static and Dynamic Evaluation. Obes Facts 13(5):1-15, 2020. e-Pub 2020. PMID: 33080591.
- Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR. B7-H4 is Inversely Correlated with T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer. Appl Immunohistochem Mol Morphol 27(7):515-522, 2019. e-Pub 2019. PMID: 29189263.
- Pagnotti GM, Styner M, Uzer G, Patel VS, Wright LE, Ness KK, Guise TA, Rubin J, Rubin CT. Combating Osteoporosis and Obesity with Exercise: Leveraging Cell Mechanosensitivity. Nat Rev Endocrinol 15(6):339-355, 2019. e-Pub 2019. PMID: 30814687.
- Patel VS, Chan ME, Pagnotti GM, Frechette DM, Rubin J, Rubin CT. Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity-Induced Adipose Tissue Dysfunction in Adult Mice. Obesity (Silver Spring) 10(10):1745-1753, 2017. e-Pub 2017. PMID: 28840647.
- Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J. Exercise Decreases Marrow Adipose Tissue Through B-Oxidation in Obese Running Mice. J Bone Miner Res 8(8):1692-1702, 2017. e-Pub 2017. PMID: 28436105.
- Altieri MS, Pagnotti GM, Corthals A, Shroyer K, Pryor AD, Talamini M, Telem DA. Autologous Augmentation of Hiatal Hernia Repair with Filtered Platelet Concentrate Improves Tissue Remodeling in a Swine Model. Surg Endosc 31(4):1591-98, 2017. e-Pub 2017. PMID: 27924393.
- Pagnotti GM, Chan ME, Adler BJ, Shroyer KR, Rubin J, Bain SD, Rubin CT. Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma. Bone 90:69-79, 2016. e-Pub 2016. PMID: 27262776.
- Pagnotti GM, Styner M. Exercise regulation of marrow adipose tissue. Front Endocrinol (Lausanne) 7(JUL):94, 2016. e-Pub 2016. PMID: 27471493.
- Wright LE, Ottewell PD, Rucci N, Peyruchaud O, Pagnotti GM, Chiechi A, Buijs JT, Sterling JA. Murine models of breast cancer bone metastasis. Bonekey Rep 5:804, 2016. e-Pub 2016. PMID: 27867497.
- Altieri MS, Shroyer KR, Pryor A, Pagnotti GM, Ete Chan M, Talamini M, Telem DA. The association between sleeve gastrectomy and histopathologic changes consistent with esophagitis in a rodent model. Surg Obes Relat Dis 11(6):1289-94, 2015. e-Pub 2015. PMID: 26048523.
- Wallace IJ, Pagnotti GM, Rubin-Sigler J, Naeher M, Copes LE, Judex S, Rubin CT, Demes B. Focal enhancement of the skeleton to exercise correlates with responsivity of bone marrow mesenchymal stem cells rather than peak external forces. J Exp Biol 218(Pt 19):3002-9, 2015. e-Pub 2015. PMID: 26232415.
- Styner M, Pagnotti GM, Galior K, Wu X, Thompson WR, Uzer G, Sen B, Xie Z, Horowitz MC, Styner MA, Rubin C, Rubin J. Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice. Endocrinology 156(8):2753-61, 2015. e-Pub 2015. PMID: 26052898.
- Styner M, Thompson WR, Galior K, Uzer G, Wu X, Kadari S, Case N, Xie Z, Sen B, Romaine A, Pagnotti GM, Rubin CT, Styner MA, Horowitz MC, Rubin J. Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise. Bone 64(64):39-46, 2014. e-Pub 2014. PMID: 24709686.
- Adler BJ, Green DE, Pagnotti GM, Chan ME, Rubin CT. High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche. PLoS One 9(3):e90639, 2014. e-Pub 2014. PMID: 24595332.
- Pagnotti GM, Adler BJ, Green DE, Chan ME, Frechette DM, Shroyer KR, Beamer WG, Rubin J, Rubin CT. Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone 51(3):570-7, 2012. e-Pub 2012. PMID: 22584009.
- Ayong L, Pagnotti GM, Tobon AB, Chakrabarti D. Identification of Plasmodium falciparum family of SNAREs. Mol Biochem Parasitol 152(2):113:22, 2007. e-Pub 2007. PMID: 17240462.
Invited Articles
- Pagnotti GM, Thompson WR, Guise TA, Rubin CT. Suppression of Cancer-Associated Bone Loss Through Dynamic Mechanical Loading. Bone 150:115998, 2021. e-Pub 2021. PMID: 33971314.
Other Articles
- Pagnotti GM, Trivedi T, Mohammad KS Translational Strategies to Target Metastatic Bone Disease. Cells 11(8), 2022. PMID: 35455987.
- Little-Letsinger SE, Rubin J, Diekman B, Rubin CT, McGrath C, Pagnotti GM, Klett EL, Styner M Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis. Semin Cell Dev Biol 123:22-35, 2022. PMID: 34489173.
- Trivedi T, Pagnotti GM, Guise TA, Mohammad KS The Role of TGF-β in Bone Metastases. Biomolecules 11(11):1643, 2021. PMID: 34827641.
- Little-Letsinger SE, Pagnotti GM, McGrath C, Styner M Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. Curr Osteoporos Rep 18(6):774-789, 2020. PMID: 33068251.
Abstracts
- McGrath C, Little-Letsinger S, Pagnotti GM, Sen B, Xie Z, Uzer G, Uzer GB, Zong X, Ehrmann BM, Wallace D, Styner MA, Rubin J, Styner M. Diet Stimulated Marrow Adiposity Fails to Worsen Early, Age-Related Bone Loss; American Society of Bone and Mineral Research, 2023. e-Pub 2023.
- Fu J, Li S, Ma H, Yang J, Brown L, Pagnotti GM, Weiss S, Mapara M, Lentzsch S. The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease, 2022. e-Pub 2022.
- Pagnotti GM, John SK, Trivedi T, Wilson RG, She Y, Wright LE, Murthy S, Suresh S, Rubin CT, Thompson WR, Mohammad KS, Guise TA. Low intensity vibration combined with zoledronic acid improves bone mass and fracture resistance in completely estrogen-deprived mice, 2022. e-Pub 2022.
- Fu J, Li S, Ma H, Jun Yang J, Brown L, Pagnotti GM, Weiss S, Mapara M, Lentzsch S. The role of checkpoint inhibitor PD-1H/VISTA in osteoclast activation and bone disease in multiple myeloma, 2022. e-Pub 2022.
- Guise TA, Pagnotti GM. A Mechanosensitive Peri-Arteriolar Niche for Osteogenesis and Lymphopoiesis, 2021. e-Pub 2021.
- Rubin CT, Chan ME, Adler BJ, Green DE, Pagnotti GM, Judex S, Rubin JE. Fate Selection and Viability of Mesenchymal and Hematopoietic Stem Cell Populations, Disrupted by Obesity, Aging and Disuse, are Rescued by Low Intensity Mechanical Signals. Orthopaedic Proceedings SUPP 16(95-B), 2013. e-Pub 2013.
- Bagheri-Yarmand R, Kidd JL, Pagnotti GM, Trivedi T, Guerra L, Martinez JA, Wan X, Song JH, Lin S, Guise TA. Activating RET Mutations Promotes Osteoblastic Bone Metastasis by Stimulating Osteoblast Activity and Inhibiting Osteoclastogenesis via Regulation of Osteoprotegerin. American Society for Bone and Mineral Research Annual Meeting.
- . Mechanical Signals Preserve Bone and Muscle While Suppressing Adiposity in a Murine Model of Complete Estrogen Deprivation. American Society for Bone and Mineral Research Annual Conference.
- . Low Intensity Vibration Enhances the Effects of Zoledronic Acid on Bone Mass and Strength. American Society for Bone and Mineral Research.
- . Low Magnitude Mechanical Signals Influence on Cancer-Associated Bone Loss. Advances in Mineral Metabolism.
- . Mechanical Signals Suppress Osteoclast-Mediated Bone Destruction and Inhibit Myeloma Cell Growth. American Society for Clinical and Translational Science Annual Conference.
- . Low Magnitude Mechanical Signals Enhance the Effects of Zoledronic Acid to Reduce Osteolytic Lesion Area and Improve Cardiac Function in a Murine Model of Breast Cancer Bone Metastases. American Society for Bone and Mineral Research Annual Conference - Virtual.
- . Low Magnitude Mechanical Signals Enhance the Effects of Zoledronic Acid to Reduce Osteolytic Lesion Area and Improve Cardiac Function in a Murine Model of Breast Cancer Bone Metastases. Cancer and Bone Society.
- . The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease. 63rd Annual American Society of Hematology Meeting.
- . The Role of Checkpoint Inhibitor PD-1H/VISTA in Multiple Myeloma Bone Disease. 18th International Myeloma Workshop.
- . Attenuating Myeloma-induced Bone Loss and Preserving Muscle Function Utilizing Low Intensity Vibrations and Carfilzomib to Suppress Excess TGF-β in the Bone Marrow Microenvironment. Bone Disease Program of Texas Research Retreat Conference.
- . RET Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer. The American Society for Bone and Mineral Research Annual Conference.
- . Deletion of the Auxiliary Voltage-Sensitive Calcium Channel α2δ1 Subunit Pushes Mesenchymal Stem Cells Towards an Adipogenic over Osteogenic Lineage Commitment. The American Society for Bone and Mineral Research Annual Conference.
- . Low Intensity Vibrations Combined with Zoledronic Acid Reduce Osteolytic Lesion Area from Breast Cancer Bone Metastases. The American Society for Bone and Mineral Research Annual Conference.
- Pagnotti GM, Bagheri-Yarmand R. RET promotes osteoblastic lesions in medullary thyroid carcinoma bone metastasis by increasing osteoblast differentiation inhibited by small-molecular ONC201. American Thyroid Association Annual Conference.
- Pagnotti GM, Willis M, John SK, Murthy S, Trivedi T, She Y, Wright LE, Suresh S, Thompson WR, Rubin CT, Mohammad KS, Guise TA. Low Intensity Vibration Alters Small-Chain Fatty Acid Metabolism in a Murine Model of Complete Estrogen Deprivation. American Society of Bone and Mineral Research (ASBMR) 2023 Annual Meeting.
- Wan X, Corn P, Yang J, Labanca E, Fong E, Pagnotti GM, Yuan S, Troncoso P, Logothetis C, Navone N, Guise TA. Dovitinib Mitigated Prostate Cancer Bone Metastases via Inhibiting the FGF Pathway. Cancer and Bone Society Annual Meeting.
- Pagnotti GM, Touray AF, Wan X, Guise TA. Bone Loss and Muscle Weakness in Myeloma-Bearing Mice Treated with Proteasome Inhibitor is Partially Attenuated with Low Intensity Vibration Peer-reviewed conference presentation. Cancer and Bone Society Annual Meeting.
- Bagheri-Yarmand R, Pagnotti GM. Activating RET mutations promotes osteoblastic bone metastasis by inhibiting osteoclastogenesis and stimulating osteoblast activity via regulation of osteoprotegerin. American Association for Cancer Research Annual Meeting.
- . Sleeve Gastrectomy Compromises Skeletal Morphology and Influences Bone Marrow of Obese Rats. American Society for Metabolic and Bariatric Surgery 31st Annual Meeting.
- . Using Virtual Reality to Improve the Compliance of Children and Adults to Daily Vibration Treatment While Measuring Treatment Efficacy. Biomedical Engineering Society.
- . Mechanical Signals Improve Bone Quality Compromised by Type 2 Diabetes, Potentially by Enhancing the Bone Marrow Mesenchymal Stem Cell Population and its Paracrine Regulation of Bone-forming Osteoblasts. American Society for Bone and Mineral Research.
- . The Use of Bone Densitometry as a Clinical Tool to Evaluate Healing of a Percutaneous Prosthetic Attachment Implant. World Congress of Biomechanics.
- . Low-Intensity Vibration is Tolerated in Animals with Percutaneously Attached Prosthetics. World Congress of Biomechanics.
- . Sleeve Gastrectomy on Obese Rats Impairs Trabecular Bone in Quantity and Quality. Biomedical Engineering Society.
- . Osteopenia and Osteolysis Resulting from Multiple Myeloma Partially Recovered Following Low Intensity Mechanical Signaling Intervention. American Society for Bone and Mineral Research.
- . The Association Between Sleeve Gastrectomy and Histopathologic Changes Consistent with Esophagitis in a Rodent Model. American Society for Metabolic and Bariatric Surgery 31st Annual Meeting.
- . Exercise Regulation of Marrow Fat in the Setting of PPARy Agonist Treatment. American Society for Bone and Mineral Research.
- . Low Intensity Vibration Amplifies Beneficial Effects of Sleeve Gastrectomy on Bone Marrow Niche. Biomedical Engineering Society.
- . Sleeve Gastrectomy on Obese Rats Reduces the Quantity of Cortical Bone at the Mid Diaphysis. Biomedical Engineering Society.
- . Low Magnitude Mechanical Signals Improve Serum Glucose Tolerance and Decrease Adipocyte Size in Obesity. American Diabetes Association.
- . Low Intensity Mechanical Signals Slow Tumor Progression and Osteolysis in a Murine Model of Multiple Myeloma. American Society for Bone and Mineral Research.
- . Exercise diminishes obesity-associated Marrow fat as quantified by Magnetic Resonance Imaging (MRI). American Society for Bone and Mineral Research.
- . The Effects of Low Intensity Vibration on Bone Mineral Density in the Intact Limb of Animals with a Percutaneously Attached Endoprosthesis. Summer Biomechanics, Bioengineering and Biotransport.
- . Continuous Cocaine Administration Results in Significant Trabecular Bone Deterioration. Biomedical Engineering Society.
- . Exercise Shrinks Marrow Adipocytes by Burning Fat. American Society for Bone and Mineral Research.
- . Biology Trumps Mechanics: Bone Adaptation to Exercise Correlates More Closely to Bone Marrow Stem Cell Responsivity than Peak Forces. American Association of Physical Anthropologists.
- . Bodies in Motion: Biomechanical Data Acquisition with a Skeleton Tracking Sensor. Biomedical Engineering Society.
- . The Effects of Low Magnitude Mechanical Signals on Myeloma-induced Osteolysis are Both Anti-resorptive and Systemic. American Society for Bone and Mineral Research.
- . Low Intensity Vibrations are Associated with Increased Strength, Reduced Adiposity, and Improved Glucose Tolerance in Mice with Complete Estrogen Deprivation. American Society for Bone and Mineral Research.
- . Effects of LIV Pre-treatment on Musculoskeletal Endpoints in Mice Following Complete Estrogen Deprivation. Midwest Tumor Microenvironment.
- . A Novel ex-vivo Model of Prolonged Osteoblast Suppression in Multiple Myeloma. American Society for Hematology.
- . Mechanical Signals Retain Musculoskeletal Endpoints While Suppressing Adiposity in a Murine Model of Compete Estrogen Deprivation. MolPharm and Cancer and Bone Society.
- . Disruption of Nucleo-Cytoskeletal Connectivity Impairs Mechanical Competence of MDA-MB-231 Cells and Regulates Responses to Low Magnitude Mechanical Forces. American Society for Bone and Mineral Research.
- . Mechanical Signals Partially Preserve Bone Quality in Animal Models of Ovarian Cancer While Promoting the Mesenchymal Progenitor Pool's Efficacy in Slowing Complications of the Disease. American Society for Bone and Mineral Research.
- . Preservation of Bone Mass and Life Expectancy in an Aged Murine Model of Spontaneous Granulosa Cell Ovarian Cancer Following Daily Bouts of Low Magnitude Mechanical Signals. International Bone and Mineral Research Cancer-Induced Bone Disease.
- . Running Decreases Marrow Adipose Tissue in Chow and High Fat Fed Mice. American Society for Bone and Mineral Research.
- . Immunomodulatory Role of Mechanical Signals in Regulating the Expansion of Hematopoietic Precursors in a Murine Model of Multiple Myeloma. International Bone and Mineral Research Cancer-Induced Bone Disease.
- . Improved Bone Quality in Diet-Induced Obesity by Low Intensity Vibrations is paralleled by Suppressed Bone Marrow Adiposity and Reduced Pro-Inflammatory State of Mesenchymal Stem Cells. American Society for Bone and Mineral Research.
- . Immunomodulatory Role of Mechanical Signals in Regulating the Expansion of Hematopoietic Precursors in a Murine Model of Multiple Myeloma. American Society for Bone and Mineral Research.
Book Chapters
- Pagnotti GM, Marino S, Petrusca D, Bellido T, Roodman GD, Delgado-Calle J. Role of osteoblasts in cancer-induced bone disease. In: Encyclopedia of Bone Biology, 201-218, 2020.
Selected Presentations & Talks
Local Presentations
- 2025. Vitamin D and its Impact on Bone. Invited. Endocrine Fellows Seminar, US.
- 2025. Addressing Cancer-Associated Bone Loss with an Engineering Career. Invited. Missouri City, Texas, US.
- 2023. Skeletal Mechanosensitivity: A Means to Suppress Cancer-Associated Bone Loss. Invited. College Station, Texas, US.
- 2023. Osteomorphs: "The Silent Assailant Following Denosumab Withdrawal". Invited. Houston, TX, US.
- 2022. Skeletal Mechanosensitivity: A Means to Suppress Cancer-Associated Bone Loss. Invited. Houston, TX, US.
- 2022. Skeletal Mechanosensitivity: A Means to Suppress Cancer-Associated Bone Loss. Invited. Little Rock, AR, US.
- 2021. Attenuating Myeloma-induced Bone Loss and Preserving Muscle Function Utilizing Low Intensity Vibrations and Carfilzomib to Suppress Excess TGF-β in the Bone Marrow Microenvironment. Conference. Houston, TX, US.
- 2021. Skeletal Mechanosensitivity: A Means to Suppress Cancer-Associated Bone Loss. Invited. Houston, TX, US.
- 2021. Mechanical Signals Deter Bone Loss and Muscle Weakness in the Setting of Breast Cancer Bone Metastasis. Invited. Houston, TX, US.
- 2021. Utilizing Mechanical Signals to Suppress Cancer-Associated Bone Loss. Invited. Houston, TX, US.
- 2020. Suppressing Myeloma-Induced Bone Loss and Muscle Wasting Utilizing Low Magnitude Mechanical Signals and Carfilzomib to Modulate the Tumor Microenvironment. Conference. Bone Disease Program of Texas Annual Retreat. Houston, TX, US.
- 2019. Low Magnitude Mechanical Signals Suppress Bone and Muscle Loss in a Murine Model of Complete Estrogen Deprivation Bone and Muscle Crosstalk Meeting. Invited. Indianapolis, IN, US.
- 2019. Utilizing Mechanical Signals to Suppress Cancer-Associated Bone Loss. Invited. Graduate Series Seminar. Indianapolis, IN, US.
- 2018. Mechanical Signals Alter Myeloma Cell-Cycle and Indirectly Attenuate Resorption. Invited. Indianapolis, IN, US.
- 2017. Effects of LIV Pre-treatment on Musculoskeletal Endpoints in Mice Following Complete Estrogen Deprivation. Invited. Indianapolis, IN, US.
- 2017. Effects of LIV Pre-treatment on Musculoskeletal Endpoints in Mice Following Complete Estrogen Deprivation. Conference. Effects of LIV Pre-treatment on Musculoskeletal Endpoints in Mice Following Complete Estrogen Deprivation. St. Louis, MO, US.
- 2016. Mechanical Signals as a Means to Preserve Bone and Suppress Tumor Progression in Murine Cancer Models. Invited. Bone and Mineral Research Seminar. Indianapolis, IN, US.
- 2015. Mechanical Signals: Making Strides Against Cancer-Induced Osteoporosis. Invited. Post-Doctoral Spotlight Symposium. Stony Brook, NY, US.
- 2012. Preservation of Bone Mass and Longevity in an Aged Murine Model of Spontaneous Granulosa Cell Ovarian Cancer Following Daily Bouts of Low Magnitude Mechanical Signals. Invited. Bronx, NY, US.
National Presentations
- 2021. RET Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer. Poster. The American Society for Bone and Mineral Research Annual Conference. San Diego, CA, US.
- 2021. Deletion of the Auxiliary Voltage-Sensitive Calcium Channel α2δ1 Subunit Pushes Mesenchymal Stem Cells Towards an Adipogenic over Osteogenic Lineage Commitment. Poster. The American Society for Bone and Mineral Research Annual Conference. San Diego, CA, US.
- 2021. Low Intensity Vibrations Combined with Zoledronic Acid Reduce Osteolytic Lesion Area from Breast Cancer Bone Metastases. Conference. The American Society for Bone and Mineral Research Annual Conference. San Diego, CA, US.
- 2021. The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease. Conference. 63rd Annual American Society of Hematology Meeting. Atlanta, GA, US.
- 2020. Low Magnitude Mechanical Signals Enhance the Effects of Zoledronic Acid to Reduce Osteolytic Lesion Area and Improve Cardiac Function in a Murine Model of Breast Cancer Bone Metastases. Conference. American Society for Bone and Mineral Research Annual Conference - Virtual Platform. Seattle, WA, US.
- 2020. Low Magnitude Mechanical Signals Enhance the Effects of Zoledronic Acid to Reduce Osteolytic Lesion Area and Improve Cardiac Function in a Murine Model of Breast Cancer Bone Metastases. Conference. Cancer and Bone Society Annual Meeting - Virtual Meeting, US.
- 2019. Low Magnitude Mechanical Signals Influence on Cancer-Associated Bone Loss. Conference. Advances in Mineral Metabolism Annual Meeting. Snowmass, CO, US.
- 2019. Low Intensity Vibration Enhances the Effects of Zoledronic Acid on Bone Mass and Strength. Conference. Orlando, FL, US.
- 2019. Mechanical Signals Suppress Osteoclast-Mediated Bone Destruction and Inhibit Myeloma Cell Growth. Conference. Washington, DC, US.
- 2017. Low Intensity Vibrations are Associated with Increased Strength, Reduced Adiposity, and Improved Glucose Tolerance in Mice with Complete Estrogen Deprivation. Conference. Denver, CO, US.
- 2017. A Novel ex-vivo Model of Prolonged Osteoblast Suppression in Multiple Myeloma. Conference. Atlanta, GA, US.
- 2016. Biology Trumps Mechanics: Bone Adaptation to Exercise Correlates More Closely to Bone Marrow Stem Cell Responsivity than Peak Forces. Conference. American Association of Physical Anthropologists Annual Conference. Atlanta, GA, US.
- 2016. Bodies in Motion: Biomechanical Data Acquisition with a Skeleton Tracking Sensor. Conference. Minneapolis, MN, US.
- 2016. Exercise Shrinks Marrow Adipocytes by Burning Fat. Conference. Atlanta, GA, US.
- 2016. The Effects of Low Magnitude Mechanical Signals on Myeloma-induced Osteolysis are Both Anti-resorptive and Systemic. Conference. Atlanta, GA, US.
- 2016. Continuous Cocaine Administration Results in Significant Trabecular Bone Deterioration. Conference. Minneapolis, MN, US.
- 2015. Exercise diminishes obesity-associated Marrow fat as quantified by Magnetic Resonance Imaging (MRI). Conference. Seattle, WA, US.
- 2015. Low Intensity Mechanical Signals Slow Tumor Progression and Osteolysis in a Murine Model of Multiple Myeloma. Conference. Seattle, WA, US.
- 2015. The Effects of Low Intensity Vibration on Bone Mineral Density in the Intact Limb of Animals with a Percutaneously Attached Endoprosthesis. Conference. Snowbird, UT, US.
- 2014. Low Intensity Vibration Amplifies Beneficial Effects of Sleeve Gastrectomy on Bone Marrow Niche. Conference. San Antonio, TX, US.
- 2014. Sleeve Gastrectomy on Obese Rats Impairs Trabecular Bone in Quantity and Quality. Conference. San Antonio, TX, US.
- 2014. Using Virtual Reality to Improve the Compliance of Children and Adults to Daily Vibration Treatment While Measuring Treatment Efficacy. Conference. San Antonio, TX, US.
- 2014. Exercise Regulation of Marrow Fat in the Setting of PPARy Agonist Treatment. Conference. Houston, TX, US.
- 2014. Low-Intensity Vibration is Tolerated in Animals with Percutaneously Attached Prosthetics. Conference. Boston, MA, US.
- 2014. Osteopenia and Osteolysis Resulting from Multiple Myeloma Partially Recovered Following Low Intensity Mechanical Signaling Intervention. Conference. Houston, TX, US.
- 2014. Mechanical Signals Improve Bone Quality Compromised by Type 2 Diabetes, Potentially by Enhancing the Bone Marrow Mesenchymal Stem Cell Population and its Paracrine Regulation of Bone-forming Osteoblasts. Conference. Houston, TX, US.
- 2014. The Use of Bone Densitometry as a Clinical Tool to Evaluate Healing of a Percutaneous Prosthetic Attachment Implant. Conference. Boston, MA, US.
- 2014. Low Magnitude Mechanical Signals Improve Serum Glucose Tolerance and Decrease Adipocyte Size in Obesity. Conference. Chicago, IL, US.
- 2014. Sleeve Gastrectomy on Obese Rats Reduces the Quantity of Cortical Bone at the Mid Diaphysis. Conference. San Antonio, TX, US.
- 2014. Sleeve Gastrectomy Compromises Skeletal Morphology and Influences Bone Marrow of Obese Rats. Conference. American Society for Metabolic and Bariatric Surgery 31st Annual Meeting. Boston, MA, US.
- 2014. The Association Between Sleeve Gastrectomy and Histopathologic Changes Consistent with Esophagitis in a Rodent Model. Conference. American Society for Metabolic and Bariatric Surgery 31st Annual Meeting. Boston, MA, US.
- 2013. Running Decreases Marrow Adipose Tissue in Chow and High Fat Fed Mice. Conference. Baltimore, MD, US.
- 2013. Immunomodulatory Role of Mechanical Signals in Regulating the Expansion of Hematopoietic Precursors in a Murine Model of Multiple Myeloma. Conference. Miami, FL, US.
- 2013. Immunomodulatory Role of Mechanical Signals in Regulating the Expansion of Hematopoietic Precursors in a Murine Model of Multiple Myeloma. Conference. Baltimore, MD, US.
- 2013. Improved Bone Quality in Diet-Induced Obesity by Low Intensity Vibrations is paralleled by Suppressed Bone Marrow Adiposity and Reduced Pro-Inflammatory State of Mesenchymal Stem Cells. Conference. Baltimore, MD, US.
- 2011. Preservation of Bone Mass and Life Expectancy in an Aged Murine Model of Spontaneous Granulosa Cell Ovarian Cancer Following Daily Bouts of Low Magnitude Mechanical Signals. Conference. Chicago, IL, US.
- 2011. Mechanical Signals Partially Preserve Bone Quality in Animal Models of Ovarian Cancer While Promoting the Mesenchymal Progenitor Pool's Efficacy in Slowing Complications of the Disease. Conference. San Diego, CA, US.
International Presentations
- 2025. The Effects of Low Magnitude Mechanical Loading on Preserving Bone and Muscle Function in Myeloma-Bearing Mice Being Treated with Proteasome Inhibitor. Invited. Joint Meeting of the Cancer and Bone Society Asia-Pacific Conference and The 13th Annual Seoul Symposium on Bone Health and the 37th Congress of the Korean Society for Bone and Mineral Research. Seoul, KR.
- 2024. Bone Loss and Muscle Weakness in Myeloma-Bearing Mice Treated with Proteasome Inhibitor is Partially Attenuated with Low Intensity Vibration. Conference. Cancer and Bone Society Annual Meeting. Sheffield, GB.
- 2021. The Role of Checkpoint Inhibitor PD-1H/VISTA in Multiple Myeloma Bone Disease. Conference. 18th International Myeloma Workshop. Vienna, AT.
- 2018. Disruption of Nucleo-Cytoskeletal Connectivity Impairs Mechanical Competence of MDA-MB-231 Cells and Regulates Responses to Low Magnitude Mechanical Forces. Conference. American Society for Bone and Mineral Research Annual Meeting. Montreal, CA.
- 2018. Mechanical Signals Preserve Bone and Muscle While Suppressing Adiposity in a Murine Model of Complete Estrogen Deprivation. Conference. American Society for Bone and Mineral Research Annual Conference. Montreal, CA.
- 2018. Mechanical Signals Retain Musculoskeletal Endpoints While Suppressing Adiposity in a Murine Model of Compete Estrogen Deprivation. Poster. MolPharm and Cancer and Bone Society Annual Meetings. Oxford, GB.
Grant & Contract Support
| Date: | 2025 - Present |
| Title: | The Effects of Low Magnitude Mechanical Signals on Suppressing Musculoskeletal Degeneration in a Murine Model of Prostate Cancer Undergoing Androgen Deprivation Therapy |
| Funding Source: | Prostate Cancer Foundation |
| Role: | Early-Stage Investigator |
| Date: | 2025 - 2030 |
| Title: | Exercise, Diabetes Therapy, and Musculoskeletal Health |
| Funding Source: | NIH |
| Role: | Co-I, PDPI (10%) |
| Date: | 2024 - 2027 |
| Title: | Disrupting tumor-bone crosstalk to overcome solid cancer-associated mortality and morbidity; Project 3: Disrupting TGFBI to overcome bone metastasis progression |
| Funding Source: | CPRIT, MIRA |
| Role: | Co-I, (15%) |
| Date: | 2024 - 2029 |
| Title: | Role of RET Mutations in medullary thyroid cancer bone metastases |
| Funding Source: | NIH/NCI |
| Role: | Co-I, (10%) |
| Date: | 2024 - Present |
| Title: | The role of the mechanical properties of the bone microenvironment on renal cell carcinoma bone metastases |
| Funding Source: | DoD |
| Role: | PI |
| Date: | 2024 - 2027 |
| Title: | Role of bone-derived TGF-beta in breast cancer-associated cognitive dysfunction |
| Funding Source: | CPRIT, MIRA |
| Role: | Co-I, (10%) |
| Date: | 2021 - 2022 |
| Title: | Center for Clinical and Translational Sciences Preclinical Modeling Pilot Program Award - The Effects of Low Intensity Vibration on Suppressing Musculoskeletal Degeneration in Mice Undergoing Androgen Deprivation |
| Funding Source: | NIH/NCATS |
| Role: | PI |
| Date: | 2021 - 2022 |
| Title: | Attenuating Myeloma-induced Bone Loss and Preserving Muscle Function Utilizing Low Intensity Vibrations and Carfilzomib to Suppress Excess TGF-β in the Bone Marrow Microenvironment |
| Funding Source: | Bone Disease Program of Texas |
| Role: | PI |
| Date: | 2020 - 2025 |
| Title: | Cancer Research Prevention Institute of Texas (CPRIT) RR190108 Established Investigator Award |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RR190108 |
| Date: | 2017 - 2019 |
| Title: | Mitigating myeloma-induced muscle wasting using mechanical signals by modulating the tumor microenvironment |
| Funding Source: | CTSI |
| Role: | Postdoctoral Fellow, (10%) |
| ID: | TL1/UL1-TR002531 |
| Date: | 2016 - 2020 |
| Title: | Effects of low magnitude mechanical signals on breast cancer metastasis |
| Funding Source: | Department of Defense (DOD) |
| Role: | Postdoctoral Fellow |
| ID: | DOD BC150678 |
| Date: | 2015 - 2016 |
| Title: | Commercialization Grant |
| Funding Source: | Stony Brook University Center for Biotechnology (REACH) Commercialization Grant |
| Role: | Research Scientist, (100%) |
Patient Reviews
CV information above last modified April 02, 2025