Gabriel M. Pagnotti, Ph.D.
Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2014 | SUNY Stony Brook University, Stony Brook, NY, USA, PHD, Biomedical Engineering |
| 2008 | University of South Florida, Tampa, FL, USA, MS, Biomedical Engineering |
| 2002 | University of Central Florida, Orlando, FL, USA, BS, Electrical Engineering |
Postgraduate Training
| 2017-2020 | Postdoctoral Fellow, Endocrinology/Hematology, Indiana University, Indianapolis, IN |
| 2014-2016 | Postdoctoral Associate, Biomedical Engineering, SUNY Stony Brook University, Stony Brook, NY |
Honors & Awards
| 2021 | Lawrence Award, Bone Disease Program of Texas |
Selected Publications
Peer-Reviewed Articles
- Nagata Y, Miyagawa K, Ohata Y, Petrusca DN, Pagnotti GM, Mohammad KS, Guise TA, Windle JJ, David Roodman G, Kurihara N. Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease. J Cell Biochem 122(3-4):335-348, 2021. e-Pub 2020. PMID: 33107091.
- Little-Letsinger SE, Pagnotti GM, McGrath C, Styner M. Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. Curr Osteoporos Rep 18(6):774-789, 2020. e-Pub 2020. PMID: 33068251.
- Pagnotti GM, Haider A, Yang A, Cottell KE, Tuppo CM, Tong KY, Pryor AD, Rubin CT, Chan ME. Postural Stability in Obese Preoperative Bariatric Patients Using Static and Dynamic Evaluation. Obes Facts 13(5):1-15, 2020. e-Pub 2020. PMID: 33080591.
- Pagnotti GM, Atkinson RM, Romeiser J, Akalin A, Korman MB, Shroyer KR. B7-H4 is Inversely Correlated with T-Cell Infiltration in Clear Cell but Not Serous or Endometrioid Ovarian Cancer. Appl Immunohistochem Mol Morphol 27(7):515-522, 2019. PMID: 29189263.
- Pagnotti GM, Styner M, Uzer G, Patel VS, Wright LE, Ness KK, Guise TA, Rubin J, Rubin CT. Combating Osteoporosis and Obesity withExercise: Leveraging Cell Mechanosensitivity. Nat Rev Endocrinol 15(6):339-355, 2019. PMID: 30814687.
- Xin Y, Wright Le, Pagnotti GM, Uzer G, Powerll KM, Wallace J, Sankar U, Rubin CT, Mohammad KS, Guise TA, Thompson WR. Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling to Osteoclasts Requires Nucleo-Cytoskeletal Connectivity. Bone Reports, 2019.
- Patel VS, Chan ME, Pagnotti GM, Frechette DM, Rubin J, Rubin CT. Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity-Induced Adipose Tissue Dysfunction in Adult Mice. Obesity (Silver Spring) 10(10):1745-1753, 2017. e-Pub 2017. PMID: 28840647.
- Styner M, Pagnotti GM, McGrath C, Wu X, Sen B, Uzer G, Xie Z, Zong X, Styner MA, Rubin CT, Rubin J. Exercise Decreases Marrow Adipose Tissue Through B-Oxidation in Obese Running Mice. J Bone Miner Res 8(8):1692-1702, 2017. e-Pub 2017. PMID: 28436105.
- Altieri MS, Pagnotti G, Corthals A, Shroyer K, Pryor AD, Talamini M, Telem DA. Autologous Augmentation of Hiatal Hernia Repair with Filtered Platelet Concentrate Improves Tissue Remodeling in a Swine Model. Surg Endosc 31(4):1591-98, 2017. e-Pub 2016. PMID: 27924393.
- Pagnotti GM, Chan ME, Adler BJ, Shroyer KR, Rubin J, Bain SD, Rubin CT. Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma. Bone 90:69-79, 2016. e-Pub 2016. PMID: 27262776.
- Pagnotti GM, Styner M. Exercise regulation of marrow adipose tissue. Front Endocrinol (Lausanne) 7:94, 2016. e-Pub 2016. PMID: 27471493.
- Altieri MS, Shroyer KR, Pryor A, Pagnotti GM, Ete Chan M, Talamini M, Telem DA. The association between sleeve gastrectomy and histopathologic changes consistent with esophagitis in a rodent model. Surg Obes Relat Dis 11(6):1289-94, 2015. e-Pub 2015. PMID: 26048523.
- Wallace IJ, Pagnotti GM, Rubin-Sigler J, Naeher M, Copes LE, Judex S, Rubin CT, Demes B. Focal enhancement of the skeleton to exercise correlates with responsivity of bone marrow mesenchymal stem cells rather than peak external forces. J Exp Biol 218(Pt 19):3002-9, 2015. e-Pub 2015. PMID: 26232415.
- Styner M, Pagnotti GM, Galior K, Wu X, Thompson WR, Uzer G, Sen B, Xie Z, Horowitz MC, Styner MA, Rubin C, Rubin J. Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice. Endocrinology 156(8):2753-61, 2015. e-Pub 2015. PMID: 26052898.
- Styner M, Thompson WR, Galior K, Uzer G, Wu X, Kadari S, Case N, Xie Z, Sen B, Romaine A, Pagnotti GM, Rubin CT, Styner MA, Horowitz MC, Rubin J. Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise. Bone 64(64):39-46, 2014. e-Pub 2014. PMID: 24709686.
- Adler BJ, Green DE, Pagnotti GM, Chan ME, Rubin CT. High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche. PLoS One 9(3):e90639, 2014. e-Pub 2014. PMID: 24595332.
- Pagnotti GM, Adler BJ, Green DE, Chan ME, Frechette DM, Shroyer KR, Beamer WG, Rubin J, Rubin CT. Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone 51(3):570-7, 2012. e-Pub 2012. PMID: 22584009.
- Ayong L, Pagnotti G, Tobon AB, Chakrabarti D. Identification of Plasmodium falciparum family of SNAREs. Mol Biochem Parasitol 152(2):113:22, 2007. e-Pub 2006. PMID: 17240462.
Book Chapters
- Pagnotti GM, Marino S, Petrusca DN, Bellido TM, Roodman GD, Delgado-Calle J. Role of osteoblast in cancer in bone. In: Encyclopedia of Bone Biology. Elsevier, 2019.
Grant & Contract Support
| Title: | |
| Funding Source: | Indiana University Purdue University at Indianapolis |
| Role: | Postdoctoral Fellow |
| Title: | |
| Funding Source: | Stony Brook University Center for Biotechnology (REACH) Commercialization Grant |
| Role: | Research Scientist |
| Title: | Mitigating myeloma-induced muscle wasting using mechanical signals by modulating the tumor microenvironment |
| Funding Source: | CTSI |
| Role: | Postdoctoral Fellow |
| Title: | Effects of low magnitude mechanical signals on breast cancer metastasis |
| Funding Source: | Department of Defense (DOD) |
| Role: | Postdoctoral Fellow |
| Title: | Cancer Research Prevention Institute of Texas (CPRIT) RR190108 Established Investigator Award |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Attenuating Myeloma-induced Bone Loss and Preserving Muscle Function Utilizing Low Intensity Vibrations and Carfilzomib to Suppress Excess TGF-β in the Bone Marrow Microenvironment |
| Funding Source: | Bone Disease Program of Texas |
| Role: | Principal Investigator |