Gabriel O. Sawakuchi, Ph.D.
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Professor (Tenured), Department of Radiation Physics - Patient Care, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Associate Professor, Department of Biosciences, Rice University, Houston, TX
Regular Faculty Member, Graduate School of Biomedical Sciences, The University of Texas, Houston, TX
Research Interests
The Sawakuchi Lab currently focuses on the study of of DNA damage response induced by radiation and to develop innovative radiation detection technologies for applications in radiation therapy and radiation biology research. Here you can find more information about my research.
Education & Training
Degree-Granting Education
| 2007 | Oklahoma State University, Stillwater, Oklahoma, US, Physics, Ph.D |
| 2003 | University of Sao Paulo, Sao Paulo, BR, Physics, M.S |
| 2001 | University of Sao Paulo, Sao Paulo, BR, Physics, BS |
Postgraduate Training
| 2007-2010 | Postdoctoral fellow, Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Licenses & Certifications
| 2017 | Medical Physicist License awarded by the Texas Medical Board |
| 2017 | American Board of Radiology |
Experience & Service
Faculty Academic Appointments
Associate Professor (Tenured), Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2025
Assistant Professor (Tenure-Track), Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2019
Adjunct Professor, Department of Physics, Carleton University, Ottawa, 2013 - 2017
Assistant Professor, Department of Physics, Carleton University, Ottawa, 2010 - 2013
Visiting Scholar, Department of Physics, Oklahoma State University, Stillwater, OK, 2003 - 2003
Administrative Appointments/Responsibilities
GI-Physics Service Chief, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - Present
Honors & Awards
| 2025 | Best in Physics Therapy: Immunomodulatory Effects of Selective PARP1 Inhibition in Combination with Photon and Alpha Particle Therapy in Immunologically Cold Breast Cancer, American Association of Physicists in Medicine Annual Meeting, Washington, DC |
| 2025 | Best in Physics Therapy: Immunomodulatory Effects of Selective PARP1 Inhibition in Combination with Photon and Alpha Particle Therapy in Immunologically Cold Breast Cancer, American Association of Physicists in Medicine Annual Meeting, Washington, DC |
| 2024 | Science Council Session: Innovations in Medical Physics, American Association of Physicists in Medicine Annual Meeting, Los Angeles, CA |
| 2020 | 2020 Farrington Daniels Award for an outstanding paper on radiation therapy dosimetry, planning or delivery published in Medical Physics, American Association of Physicists in Medicine |
| 2020 | Editor's Choice: paper published in the Medical Physics journal (First author CH McFadden and senior author GO Sawakuchi, Med. Phys. 47, 272-281), American Association of Physicists in Medicine |
| 2020 | Cover of Medical Physics journal (Jan 2020 issue) (First author CH McFadden and senior author GO Sawakuchi, Med. Phys. 47, 272-281), American Association of Physicists in Medicine |
| 2019 | 2019 President's Recognition of Faculty Excellence in Research Excellence, The University of Texas MD Anderson Cancer Center |
| 2019 | 2019 AAPM Best in Physics Award (First author DB Flint and senior author GO Sawakuchi), American Association of Physicists in Medicine |
| 2019 | 2019 ASCO Merit Award (First author BSV Chapman), American Society of Clinical Oncology |
| 2018 | Editor's Choice: paper published in the Medical Physics journal (First author DJ O'Brien and senior author GO Sawakuchi, Med. Phys. 45, 884-897), American Association of Physicists in Medicine |
| 2017 | Editor's Choice: paper published in the Medical Physics journal (First author DJ O'Brien and senior author GO Sawakuchi, Med. Phys. 44, 3830-3838), American Association of Physicists in Medicine |
| 2017 | 2017 RRS ECI Travel Award, Radiation Research Society |
| 2016 | 2016 RRS ECI Travel Award, Radiation Research Society |
| 2014 | HPC Innovation Excellence Award, Hyperion Research and HPC User Forum |
| 2012 | One of the 20 best referees for the Physics in Medicine and Biology Journal, Phys Med Biol |
| 2012 | Early Career Researcher Supplement Award, Natural Science and Engineering Research Council of Canada |
| 2011 | One of the 20 best referees for the Physics in Medicine and Biology Journal, Phys Med Biol |
| 2005 | NASA Space Radiation Summer School Award, NASA |
| 2004 | International School on Radiation Effects in Solids Travel Award |
| 2002 - 2003 | Sao Paulo Research Foundation (FAPESP) Master of Science Scholarship, FAPESP |
| 1999 - 2001 | Sao Paulo Research Foundation (FAPESP) Undergraduate Scholarship, FAPESP |
Professional Memberships
Grant & Contract Support
| Date: | 2026 - 2026 |
| Title: | Exploring the sensitivity of Glioblastomas to Proton Therapy |
| Funding Source: | Fulbright |
| Role: | Host |
| Date: | 2024 - 2027 |
| Title: | Investigation of Rho GTPase and DUSP12 Tyrosine Phosphatase in Radio and Chemoresistance of Glioblastomas |
| Funding Source: | National Council of Scientific and Technological Development (CNPq), Brazil |
| Role: | Co-PI |
| ID: | 444397/2024-8 |
| Date: | 2024 - 2026 |
| Title: | Combination of radiation and pharmacological disruption of metabolism for immunosensitization in lung cancer |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | Co-I |
| ID: | Internal Research Grant |
| Date: | 2023 - 2025 |
| Title: | Amplifying the efficacy of low energy photons by modulating tumor metabolism |
| Funding Source: | CRnR |
| Role: | PI |
| ID: | CRnR |
| Date: | 2023 - 2028 |
| Title: | Alpha particles combined with ATR inhibition to activate the immune system: mechanisms and pre-clinical translation |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA279119-01 |
| Date: | 2021 - 2026 |
| Title: | Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | P01-CA261669-01 |
Selected Publications
Peer-Reviewed Articles
- Su, T, Yu, X, Hoseini-Ghahfarokhi, M, Flint, DB, Bright, SJ, Antunes, JI, Martinus, DK, Manandhar, M, Ben Kacem, M, Marinello, P, Pereira, EJ, Chiu, HS, Titt, U, Grosshans, DR, Schuemann, J, Willers, H, Paganetti, H, Sumazin, P, Sawakuchi, GO. Differentiation Stage Predicts Radiosensitivity in Mesenchymal-Like Pancreatic Cancer. International Journal of Radiation Oncology Biology Physics 123(1):270-281, 2025. e-Pub 2025. PMID: 40180058.
- Chiu, HS, Somvanshi, S, Chang, CT, de Bony de Lavergne, EJ, Wei, Z, Hsieh, CH, Trypsteen, W, Scorsone, K, Patel, E, Tang, TT, Flint, DB, Najaf Panah, MJ, Kim, HR, Rathi, P, Lee, YW, Woodfield, SE, Vasudevan, SA, Heczey, A, Gaber, MW, Sawakuchi, GO, Chen, TW, Mestdagh, P, Yang, X, Sumazin, P. Coordinated regulation by lncRNAs results in tight lncRNA-target couplings. Cell Genomics 5(8), 2025. e-Pub 2025. PMID: 40628267.
- Schalck, A, Tran, TM, Li, J, Sei, E, Bai, S, Hu, M, Lin, J, Bright, SJ, Reddick, S, Yang, F, Batra, H, Contreras, A, Raso, G, Stauder, MC, Hoffman, K, Reddy, JP, Nead, KT, Smith, B, Sawakuchi, GO, Woodward, W, Watowich, SS, Litton, J, Bedrosian, I, Mittendorf, EA, Le-Petross, H, Navin, N, Shaitelman, SF. The impact of breast radiotherapy on the tumor genome and immune ecosystem. Cell Reports 44(5), 2025. e-Pub 2025. PMID: 40378044.
- Shaitelman SF, Le-Petross H, Raso MG, Swanson DM, Schalck AP, Contreras A, Yang F, Muruganandham M, Zhao GZ, Sawakuchi GO, Kim LH, Batra H, Smith BD, Stauder MC, Woodward WA, Reddy JP, Litton JK, Thompson A, Bedrosian I, Mitten EA. PRECISE: Preoperative Radiotherapy to Elicit Critical Immune Stimulating Effects – A Phase II Clinical Trial. Int J Radiat Oncol Biol Phys 121(1):90-96, 2025. e-Pub 2025. PMID: 39147206.
- Flint DB, Bright SJ, McFadden CH, Konishi T, Martinus DKJ, Manandhar M, Ben Kacem M, Marinello PC, Bronk L, Shaitelman SF, Sawakuchi GO. An empirical model of carbon-ion relative biological effectiveness based on the linear correlation between radiosensitivity to photons and carbon ions. Phys Med Biol 69(24):245011, 2024. e-Pub 2024. PMID: 39530708.
- Ben Kacem M, Bright SJ, Moran E, Flint DB, Martinus DKJ, Turner BX, Qureshi I, Kolachina R, Manandhar M, Marinello PC, Shaitelman SF, Sawakuchi GO. PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy. Sci Rep 14(1):30897, 2024. e-Pub 2024. PMID: 39730675.
- Martin-Paulpeter RM, Jensen PJ, Perles LA, Sawakuchi GO, Das P, Koay EJ, Koong AC, Ludmir EB, Beddar S. Daily diagnostic quality computed tomography on rails (CTOR) image guidance for abdominal stereotactic body radiation therapy (SBRT). Cancers 16(22):3770, 2024. e-Pub 2024. PMID: 39594725.
- Bright SJ, Manandhar M, Flint DB, Kolachina R, Ben Kacem M, Martinus DKJ, Turner BX, Qureshi I, McFadden CH, Marinello PC, Shaitelman SF, Sawakuchi GO. ATR inhibition radiosensitizes cells through augmented DNA Damage and G2 cell cycle arrest abrogation. J CIin Invest Insight 9(19):e179599, 2024. e-Pub 2024. PMID: 39235982.
- Chang E, Wong FCL, Chasen BA, Erwin WD, Das P, Holliday EB, Koong AC, Ludmir EB, Minsky BD, Noticewala SS, Smith GL, Taniguchi CM, Rodriguez MJ, Beddar S, Martin-Paulpeter RM, Niedzielski JS, Sawakuchi GO, Schueler E, Perles LA, Xiao L, Szklaruk J, Park PC, Dasari AN, Kaseb AO, Kee BK, Lee SS, Overman MJ, Willis JA, Wolff RA, Tzeng CD, Vauthey JN, Koay EJ. Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume. JNCI Cancer Spectr 8(3), 2024. e-Pub 2024. PMID: 38730548.
- Taniguchi CM, Frakes JM, Aguilera TA, Palta M, Czito B, Bhutani MS, Colbert LE, Abi Jaoude J, Bernard V, Pant S, Tzeng CD, Kim DW, Malafa M, Costello J, Mathew G, Rebueno N, Koay EJ, Das P, Ludmir EB, Katz MHG, Wolff RA, Beddar S, Sawakuchi GO, Moningi S, Slack Tidwell RS, Yuan Y, Thall PF, Beardsley RA, Holmlund J, Herman JM, Hoffe SE. Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial. Lancet Oncol 24(12):1387-1398, 2023. e-Pub 2023. PMID: 38039992.
- Rhee DJ, Beddar S, Jaoude JA, Sawakuchi G, Martin R, Perles L, Yu C, He Y, Court LE, Ludmir EB, Koong AC, Das P, Koay EJ, Taniguichi C, Niedzielski JS. Dose escalation for pancreas SBRT: Potential and limitations of using daily online adaptive radiation therapy and an iterative isotoxicity automated planning approach. Adv Radiat Oncol 8(4):101164, 2023. e-Pub 2023. PMID: 36798731.
- Bright SJ, Flint DB, Martinus DKJ, Turner BX, Manandhar M, Ben Kacem M, McFadden CH, Yap TA, Shaitelman SF, Sawakuchi GO. Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons. Radiat Res 198(4):336-346, 2022. e-Pub 2022. PMID: 35939823.
- Flint DB, Ruff CE, Bright SJ, Yepes P, Wang Q, Manandhar M, Ben Kacem M, Turner BX, Martinus DKJ, Shaitelman SF, Sawakuchi GO. An empirical model of proton RBE based on the linear correlation between x-ray and proton radiosensitivity. Med Phys 49(9):6221-6236, 2022. e-Pub 2022. PMID: 35831779.
- Manandhar M, Bright SJ, Flint DB, Martinus DKJ, Kolachina RV, Ben Kacem M, Titt U, Martin TJ, Lee CL, Morrison K, Shaitelman SF, Sawakuchi GO. Effect of boron compounds on the biological effectiveness of proton therapy. Med Phys 49(9):6098-6109, 2022. e-Pub 2022. PMID: 35754208.
- Khan Z, Rooney MK, Das P, Ludmir EB, Koay EJ, Smith GL, Taniguchi C, Minsky BD, Koong AC, Sawakuchi G, Beddar S, Martin RM, Rodriguez-Bigas M, Peacock O, Chang G, Holliday EB. Intraoperative radiation after pelvic short course radiation-based total neoadjuvant therapy for patients with rectal adenocarcinoma at high risk for local recurrence. Clin Colorectal Cancer 21(3):204-211, 2022. e-Pub 2022. PMID: 35125321.
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Breast Radiation Therapy-Related Treatment Outcomes in Patients With or Without Germline Mutations on Multigene Panel Testing. Int J Radiat Oncol Biol Phys 112(2):437-444, 2022. e-Pub 2022. PMID: 34582940.
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Outcomes After Breast Radiation Therapy in a Diverse Patient Cohort With a Germline BRCA1/2 Mutation. Int J Radiat Oncol Biol Phys 112(2):426-436, 2022. e-Pub 2022. PMID: 34610390.
- Parisi, A, Sawakuchi, GO, Granville, DA, Yukihara, EG. Microdosimetric modeling of the relative efficiency of Al2O3:C (Luxel, blue emission) optically stimulated luminescent detectors exposed to ions from 1H to 132Xe. Radiation Measurements 150, 2022. e-Pub 2022.
- Niedzielski JS, Liu Y, Ng SSW, Martin RM, Perles LA, Beddar S, Rebueno N, Koay EJ, Taniguchi C, Holliday EB, Das P, Smith GL, Minsky BD, Ludmir EB, Herman JM, Koong A, Sawakuchi GO. Dosimetric Uncertainties Resulting From Interfractional Anatomic Variations for Patients Receiving Pancreas Stereotactic Body Radiation Therapy and Cone Beam Computed Tomography Image Guidance. Int J Radiat Oncol Biol Phys 111(5):1298-1309, 2021. e-Pub 2021. PMID: 34400267.
- Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions. Med Phys 48(6):3243-3261, 2021. e-Pub 2021. PMID: 33837540.
- Steinmann A, Alvarez P, Lee H, Court L, Stafford R, Sawakuchi GO, Wen Z, Fuller C, Followill D. MRIgRT head and neck anthropomorphic QA phantom: Design, development, reproducibility, and feasibility study. Med Phys 47:604-613, 2020. e-Pub 2020. PMID: 31808949.
- Kry SF, Alvarez P, Cygler JE, DeWerd LA, Howell RM, Meek S, O’Daniel J, Reft C, Sawakuchi GO, Yukihara EG, Mihailidis D. AAPM TG 191: Clinical use of luminescent dosimeters: TLDs and OSLDs. Med Phys 47:e19-e51, 2020. e-Pub 2020. PMID: 31574174.
- McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O'Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO. Isolation of time-dependent DNA damage induced by energetic carbon ions and their fragments using fluorescent nuclear track detectors. Med Phys 47(1):272-281, 2020. e-Pub 2020. PMID: 31677156.
- Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death. Int J Radiat Oncol Biol Phys 105(5):1119-1125, 2019. e-Pub 2019. PMID: 31425731.
- Steinmann A, Alvarez P, Lee H, Stafford R, Sawakuchi GO, Wen Z, Court L, Fuller C, Followill D. MRIgRT dynamic lung motion thorax anthropomorphic QA phantom: Design, development, reproducibility, and feasibility study. Med Phys 46:5124-5133, 2019. e-Pub 2019. PMID: 31506963.
- Steinmann A, O'Brien D, Stafford R, Sawakuchi G, Wen Z, Court L, Fuller C, Followill D. Investigation of TLD and EBT3 performance under the presence of 1.5T, 0.35T, and 0T magnetic field strengths in MR/CT visible materials. Med Phys 46(7):3217-3226, 2019. e-Pub 2019. PMID: 30950071.
- Thompson JM, Elliott A, D'Abrantes S, Sawakuchi GO, Hill MA. Tracking down alpha-particles: the design, characterization and testing of a shallow-angled alpha particle irradiator. Radiat Prot Dosimetry 183(1-2):264-269, 2019. e-Pub 2019. PMID: 30726978.
- Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, de la Cruz Bonilla M, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res 79(9):2327-2338, 2019. e-Pub 2019. PMID: 31043430.
- Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi C, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Krishnan S. Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma. Radiother Oncol 133:54-61, 2019. e-Pub 2019. PMID: 30935582.
- Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res 191(1):76-92, 2019. e-Pub 2019. PMID: 30407901.
- Colbert LE, Rebueno N, Moningi S, Beddar S, Sawakuchi GO, Herman JM, Koong AC, Das P, Holliday EB, Koay EJ, Taniguchi CM. Dose escalation for locally advanced pancreatic cancer: How high can we go?. Adv Radiat Oncol 3(4):693-700, 2018. e-Pub 2018. PMID: 30370371.
- Grosshans DR, Duman JG, Gaber M, Sawakuchi GO. Particle Radiation Induced Neurotoxicity in the Central Nervous System. Int J Particle Ther 5(1):74-83, 2018. e-Pub 2018. PMID: 31773021.
- Alsanea F, Therriault-Proulx F, Sawakuchi GO, Beddar S. A Real-Time Method to Simultaneously Measure Linear Energy Transfer and Dose for Proton Therapy Using Organic Scintillators. Med Phys 45(4):1782-1789, 2018. e-Pub 2018. PMID: 29446078.
- Steinmann A, Stafford RJ, Sawakuchi GO, Wen Z, Court L, Fuller CD, Followill D. Developing and characterizing MR/CT visible materials used in QA phantoms for MRgRT systems. Med Phys 45(2):773-782, 2018. e-Pub 2018. PMID: 29178486.
- O'Brien DJ, Dolan J, Pencea S, Schupp N, Sawakuchi GO. Relative dosimetry with an MR-linac: Response of ion chambers, diamond, and diode detectors for off-axis, depth dose, and output factor measurements. Med Phys 45(2):884-897, 2018. e-Pub 2018. PMID: 29178457.
- O'Brien DJ, Sawakuchi GO. Monte Carlo study of the chamber-phantom air gap effect in a magnetic field. Med Phys 44(7):3830-3838, 2017. e-Pub 2017. PMID: 28432792.
- Underwood TS, Sung W, McFadden CH, McMahon SJ, Hall DC, McNamara AL, Paganetti H, Sawakuchi GO, Schuemann J. Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Phys Med Biol 62(8):3237-3249, 2017. e-Pub 2017. PMID: 28350546.
- O'Brien DJ, Schupp N, Pencea S, Dolan J, Sawakuchi GO. Dosimetry in the presence of strong magnetic fields. J Phys Conf Ser 847:012055, 2017. e-Pub 2017.
- Chadha AS, Liu G, Chen HC, Das P, Minsky BD, Mahmood U, Delclos ME, Suh Y, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH, Wang X, Thames H, Krishnan S. Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy?. Int J Radiat Oncol Biol Phys 97(2):323-332, 2017. e-Pub 2017. PMID: 28068240.
- McFadden CH, Hallacy TM, Flint DB, Granville DA, Asaithamby A, Sahoo N, Akselrod MS, Sawakuchi GO. Time-Lapse Monitoring of DNA Damage Colocalized With Particle Tracks in Single Living Cells. Int J Radiat Oncol Biol Phys 96(1):221-7, 2016. e-Pub 2016. PMID: 27511858.
- O'Brien DJ, Roberts DA, Ibbott GS, Sawakuchi GO. Reference dosimetry in magnetic fields: formalism and ionization chamber correction factors. Med Phys 43(8):4915, 2016. e-Pub 2016. PMID: 27487908.
- Sawakuchi GO, Ferreira FA, McFadden CH, Hallacy TM, Granville DA, Sahoo N, Akselrod MS. Nanoscale measurements of proton tracks using fluorescent nuclear track detectors. Med Phys 43(5):2485, 2016. e-Pub 2016. PMID: 27147359.
- Krishnan S, Chadha AS, Suh Y, Chen HC, Rao A, Das P, Minsky BD, Mahmood U, Delclos ME, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH. Focal Radiation Therapy Dose Escalation Improves Overall Survival in Locally Advanced Pancreatic Cancer Patients Receiving Induction Chemotherapy and Consolidative Chemoradiation. Int J Radiat Oncol Biol Phys 94(4):755-65, 2016. e-Pub 2016. PMID: 26972648.
- Granville DA, Sahoo N, Sawakuchi GO. Simultaneous measurements of absorbed dose and linear energy transfer in therapeutic proton beams. Phys Med Biol 61(4):1765-79, 2016. e-Pub 2016. PMID: 26859539.
- Flint DB, Granville DA, Sahoo N, McEwen M, Sawakuchi GO. Ionization density dependence of the OSL curve shape and ratio of UV to blue emissions for Al2O3:C detectors exposed to 6 MV photon and therapeutic proton beams. Radiat Meas 89:35-43, 2016. e-Pub 2016.
- Granville DA, Sawakuchi GO. Comparison of linear energy transfer scoring techniques in Monte Carlo simulations of proton beams. Phys Med Biol 60(14):N283-91, 2015. e-Pub 2015. PMID: 26147442.
- Granville DA, Sahoo N, Sawakuchi GO. Linear energy transfer dependence of Al2O3:C optically stimulated luminescence detectors exposed to therapeutic proton beams. Radiat Meas 71:69-73, 2014. e-Pub 2014.
- Granville DA, Sahoo N, Sawakuchi GO. Calibration of the Al2O3:C optically stimulated luminescence (OSL) signal for linear energy transfer (LET) measurements in therapeutic proton beams. Phys Med Biol 59(15):4295-310, 2014. e-Pub 2014. PMID: 25029434.
- Zhu XR, Poenisch F, Lii M, Sawakuchi GO, Titt U, Bues M, Song X, Zhang X, Li Y, Ciangaru G, Li H, Taylor MB, Suzuki K, Mohan R, Gillin MT, Sahoo N. Commissioning dose computation models for spot scanning proton beams in water for a commercially available treatment planning system. Med Phys 40(4):041723, 2013. e-Pub 2013. PMID: 23556893.
- Derveni M, Allen M, Sawakuchi GO, Yukihara EG, Richter L, Sims MR, Cullen DC. Survivability of immunoassay reagents exposed to the space radiation environment on board the ESA BIOPAN-6 platform as a prelude to performing immunoassays on Mars. Astrobiology 13(1):92-102, 2013. e-Pub 2013. PMID: 23286207.
- Omotayo AA, Cygler JE, Sawakuchi GO. The effect of different bleaching wavelengths on the sensitivity of Al(2)O(3):C optically stimulated luminescence detectors (OSLDs) exposed to 6 MV photon beams. Med Phys 39(9):5457-68, 2012. e-Pub 2012. PMID: 22957613.
- Anand A, Sahoo N, Zhu XR, Sawakuchi GO, Poenisch F, Amos RA, Ciangaru G, Titt U, Suzuki K, Mohan R, Gillin MT. A procedure to determine the planar integral spot dose values of proton pencil beam spots. Med Phys 39(2):891-900, 2012. e-Pub 2012. PMID: 22320798.
- Sawakuchi GO, Yukihara EG. Analytical modeling of relative luminescence efficiency of Al2O3:C optically stimulated luminescence detectors exposed to high-energy heavy charged particles. Phys Med Biol 57(2):437-54, 2012. e-Pub 2012. PMID: 22173080.
- Bartz JA, Sykora GJ, Underwood TH, Nichiporov DN, Sawakuchi GO, Akselrod MS. Evaluation of aluminum oxide fluorescent and OSL detectors in proton radiotherapy beams. Radiat Meas 46:1974-1978, 2011. e-Pub 2011.
- Perles LA, Mirkovic D, Sawakuchi GO, Titt U. Monte Carlo investigation of rebinning material density distributions of lung parenchyma phantoms in proton therapy. Nucl Tech 175:22-26, 2011. e-Pub 2011.
- Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency. Phys Med Biol 55(23):7097-106, 2010. e-Pub 2010. PMID: 21076194.
- Sawakuchi GO, Sahoo N, Gasparian PB, Rodriguez MG, Archambault L, Titt U, Yukihara EG. Determination of average LET of therapeutic proton beams using Al2O3:C optically stimulated luminescence (OSL) detectors. Phys Med Biol 55(17):4963-76, 2010. e-Pub 2010. PMID: 20693613.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Med Phys 37(9):4960-70, 2010. e-Pub 2010. PMID: 20964215.
- Sawakuchi GO, Zhu XR, Poenisch F, Suzuki K, Ciangaru G, Titt U, Anand A, Mohan R, Gillin MT, Sahoo N. Experimental characterization of the low-dose envelope of spot scanning proton beams. Phys Med Biol 55(12):3467-78, 2010. e-Pub 2010. PMID: 20508318.
- Sawakuchi GO, Titt U, Mirkovic D, Ciangaru G, Zhu XR, Sahoo N, Gillin MT, Mohan R. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams. Phys Med Biol 55(3):711-21, 2010. e-Pub 2010. PMID: 20071752.
- Gillin MT, Sahoo N, Bues M, Ciangaru G, Sawakuchi GO, Poenisch F, Arjomandy B, Martin C, Titt U, Suzuki K, Smith AR, Zhu XR. Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas M.D. Anderson Cancer Center, Proton Therapy Center, Houston. Med Phys 37(1):154-63, 2010. e-Pub 2010. PMID: 20175477.
- Yukihara EG, Gasparian PBR, Sawakuchi GO, Ruan C, Ahmad S, Kalavagunta C, Clouse WJ, Sahoo N, Titt U. Medical applications of optically stimulated luminescence dosimeters (OSLDs). Radiat Meas 45:658-662, 2010. e-Pub 2010.
- Ciangaru G, Sahoo N, Zhu XR, Sawakuchi GO, Gillin MT. Computation of doses for large-angle Coulomb scattering of proton pencil beams. Phys Med Biol 54(24):7285-7300, 2009. e-Pub 2009. PMID: 19926912.
- Reitz G, Berger T, Bilski P, Facius R, Hajek M, Petrov V, Puchalska M, Zhou D, Bossler J, Akatov Y, Shurshakov V, Olko P, Ptaszkiewicz M, Bergmann R, Fugger M, Vana N, Beaujean R, Burmeister S, Bartlett D, Hager L, Pálfalvi J, Szabó J, O'Sullivan D, Kitamura H, Uchihori Y, Yasuda N, Nagamatsu A, Tawara H, Benton E, Gaza R, McKeever S, Sawakuchi GO, Yukihara E, Cucinotta F, Semones E, Zapp N, Miller J, Dettmann J. Astronaut's organ doses inferred from measurements in a human phantom outside the international space station. Radiat Res 171(2):225-35, 2009. e-Pub 2009. PMID: 19267549.
- Sawakuchi GO, Titt U, Mirkovic D, Mohan R. Density heterogeneities and the influence of multiple Coulomb and nuclear scatterings on the Bragg peak distal edge of proton therapy beams. Phys Med Biol 53(17):4605-19, 2008. e-Pub 2008. PMID: 18678928.
- Sawakuchi GO, Yukihara EG, McKeever SWS, Gaza R, Benton ER, Uchihori Y, Yasuda N, Kitamura H. Relative optically stimulated luminescence and thermoluminescence efficiencies of Al2O3:C dosimeters to heavy charged particles with energies relevant to space and radiotherapy dosimetry. J Appl Phys 104:124903, 2008. e-Pub 2008.
- Sawakuchi GO, Yukihara EG, McKeever SWS, Benton. Overlap of heavy charged particle tracks and the change in shape of optically stimulated luminescence curves of Al2O3:C. Radiat Meas 43:194-198, 2008. e-Pub 2008.
- Sawakuchi GO, Yukihara EG, McKeever SWS, Benton ER. Optically stimulated luminescence fluence response of Al2O3:C. Radiat Meas 43:450-454, 2008. e-Pub 2008.
- Vanhavere F, Genicot JL, O'Sullivan D, Zhou D, Spurny F, Jadrníčková I, Sawakuchi GO, Yukihara EG. DOsimetry of BIological EXperiments in SPace (DOBIES) with luminescence (OSL and TL) and track etch detectors. Radiat Meas 43:694-697, 2008. e-Pub 2008.
- Edmund JM, Anderson CE, Greilich S, Sawakuchi GO, Yukihara EG, Jain M, Hajdas W, Mattson S. Optically stimulated luminescence from Al2O3:C irradiated with 10-60 MeV protons. Nucl Instr Meth Phys Res A 580:210-213, 2007. e-Pub 2007.
- Yukihara EG, Sawakuchi GO, Guduru S, McKeever SWS, Gaza R, Benton ER. Application of the optically stimulated luminescence technique in space dosimetry. Radiat Meas 41:1126-1135, 2006. e-Pub 2006.
- Sawakuchi GO, Okuno E. The role of aluminum and titanium in the point defects of gamma irradiated natural quartz. Phys Stat Sol (c) 2:588-591, 2005. e-Pub 2005.
- Sawakuchi GO, Okuno E. Effects of high gamma ray doses in quartz. Nucl Instrum Meth Phys Res B 218:217-221, 2004. e-Pub 2004.
Review Articles
- Coll RP, Bright SJ, Martinus DKJ, Georgiou DK, Sawakuchi GO, Manning HC. Alpha Particle-Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery. Mol Imaging Biol 25(6):991-1019, 2023. e-Pub 2023. PMID: 37845582.
- Yukihara, EG, McKeever, S, Andersen, CE, Bos, AJ, Bailiff, IK, Yoshimura, EM, Sawakuchi, GO, Bossin, L, Christensen, JB. Luminescence dosimetry. Nature Reviews Methods Primers 2(1), 2022. e-Pub 2022.
- Paganetti H, Beltran C, Both S, Dong L, Flanz J, Furutani K, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nystrom H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers M, Shaitelman SF, Teo BKK, Unkelbach J, Wohlfahrt P, Lomax T. Roadmap: proton therapy physics and biology. Phys Med Biol 66(5), 2021. e-Pub 2021. PMID: 33227715.
- Bergom C, West CM, Higginson DS, Abazeed ME, Arun B, Bentzen SM, Bernstein JL, Evans JD, Gerber NK, Kerns SL, Keen J, Litton JK, Reiner AS, Riaz N, Rosenstein BS, Sawakuchi GO, Shaitelman SF, Powell SN, Woodward WA. The Implications of Genetic Testing on Radiation Therapy Decisions: A Guide for Radiation Oncologists. Int J Radiat Oncol Biol Phys 105(4):698-712, 2019. e-Pub 2019. PMID: 31381960.
Professional Educational Materials
- Sawakuchi GO, Archambault L, Scullion A, Cygler JE. Results of a survey to assess the current status of in-vivo dosimetry in Canada, 2012.
Book Chapters
- Sahoo N, Sawakuchi GO, Gillin MT, Zhu XR. Radiation Dosimetry of Proton Beams. In: Particle Radiotherapy: Emerging Technology for Treatment of Cancer. Springer India, 2016.
Patient Reviews
CV information above last modified January 20, 2026