Guang Peng, MD, PhD
Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences
About Dr. Peng
The overall goal of my laboratory is to understand the causes and consequences of genomic instability and the impact of genomic instability on immune phenotype cancer development. More specifically, by understanding and targeting the DNA repair network, our research aim to address two key questions: (1) Can we identify genetic alterations in the DNA repair network that drive tumor evolution, particularly during the transition from premalignant lesions to cancer? (2) Can we identify targeted prevention/therapeutic strategies by modulating the DNA repair network and immune phenotype? Recent work in my laboratory explores the following directions:
1. Identify genetic alterations in the DNA repair network that confers tumor evolvability: We aim to investigate the novel functions of chromatin remodeling complex SWI/SNF, human nucleases/helicases DNA2 and mutational enzyme APOBEC3B in promoting tumorigenesis by both in vitro and in vivo studies, which may lead to identification of new strategy for early detection and intervention. We are also work to understand how environmental and endogenous factors reshape the landscape of cellular genome by targeting epigenetic regulatory machineries.
2. Discover novel agents targeting the DNA repair network by genetic and chemical approaches: We aim to utilize chemical screening and bioinformatics’ tools as our drug-discovery platforms to systematically identify chemical compounds that target the DNA repair network. We will determine whether the reduction of cellular tolerance to endogenous DNA damage and altered immune responsiveness by modulating DNA repair process would open new avenues for cancer prevention and therapy.
3. Develop systems biology approaches to understand the dynamics of the DNA repair network in tumor evolvability and immunoresponsiveness:
We We aim to utilize mathematical modeling, systems biology and molecular biology approaches to understand and target the DNA repair network. These new interdisciplinary approaches will offer a revolutionary conceptual framework to determine the compound effect of the DNA repair network rather than focusing on an individual repair gene’s function in tumor evolution and anti-tumor immunity.
Research Interests
The overall goal of my laboratory is to understand the causes and consequences of genomic instability and the impact of genomic instability on immune phenotype cancer development. More specifically, by understanding and targeting the DNA repair network, our research aim to address two key questions: (1) Can we identify genetic alterations in the DNA repair network that drive tumor evolution, particularly during the transition from premalignant lesions to cancer? (2) Can we identify targeted prevention/therapeutic strategies by modulating the DNA repair network and immune phenotype? Recent work in my laboratory explores the following directions:
1. Identify genetic alterations in the DNA repair network that confers tumor evolvability: We aim to investigate the novel functions of chromatin remodeling complex SWI/SNF, human nucleases/helicases DNA2 and mutational enzyme APOBEC3B in promoting tumorigenesis by both in vitro and in vivo studies, which may lead to identification of new strategy for early detection and intervention. We are also work to understand how environmental and endogenous factors reshape the landscape of cellular genome by targeting epigenetic regulatory machineries.
2. Discover novel agents targeting the DNA repair network by genetic and chemical approaches: We aim to utilize chemical screening and bioinformatics’ tools as our drug-discovery platforms to systematically identify chemical compounds that target the DNA repair network. We will determine whether the reduction of cellular tolerance to endogenous DNA damage and altered immune responsiveness by modulating DNA repair process would open new avenues for cancer prevention and therapy.
3. Develop systems biology approaches to understand the dynamics of the DNA repair network in tumor evolvability and immunoresponsiveness:
We aim to utilize mathematical modeling, systems biology and molecular biology approaches to understand and target the DNA repair network. These new interdisciplinary approaches will offer a revolutionary conceptual framework to determine the compound effect of the DNA repair network rather than focusing on an individual repair gene’s function in tumor evolution and anti-tumor immunity.
Education & Training
Degree-Granting Education
| 2005 | University of South Carolina School of Medicine, Columbia, SC, USA, PHD, Biomedical Sciences |
| 2002 | Tongji Medical University, Wuhan, CHN, MD, Bachelor of Medicine (M.D. Equivalent) |
Experience & Service
Other Appointments/Responsibilities
Member, Faculty Academic Review Committee, Houston, TX, 2015 - Present
Advisory Committee, NCI R25E Cancer Prevention Education: Student Research Experience, Houston, TX, 2013 - Present
Advisory Committee, Cancer Prevention Research Training Program, Houston, TX, 2011 - Present
Honors & Awards
| 2015 | Investigator-Initiated Research Award, Department of Defense (DoD) Ovarian Cancer Research Program |
| 2014 | Susan G. Komen Career Catalyst Research Award |
| 2013 | Ovarian Cancer SPORE Career Development Award, NIH/NCI |
| 2012 | Landon Foundation-AACR Innovator Award for Cancer Prevention Research |
| 2012 | Texas Business Women Award, Texas Business Women Inc |
| 2011 | Howard Temin Pathway to Independence Award, National Cancer Institute |
| 2010 | Trainee of the Quarter, University of Texas MD Anderson Cancer Center |
| 2009 | Trainee Excellence Award, University of Texas MD Anderson Cancer Center |
| 2008 | Oral Presentation Award, Society of Chinese Bioscientists in America Annual Symposia, Houston, TX |
| 2008 | Postdoctoral Fellowship, Susan G. Komen for the Cure Foundation |
| 2006 | First Place in Oral Presentation, Fox Chase Cancer Center Postdoctoral and Graduate Student Research Conference, Philadelphia, PA |
| 2006 | Edward David Lustbader Prize, Fox Chase Cancer Center, Philadelphia, PA |
| 2005 | W. Morgan Newton Research Award, School of Medicine, University of South Carolina |
| 2005 | First Place in Oral Presentation, Graduate Student Day, The Graduate School, University of South Carolina |
| 2004 | Best Student Poster Presentation, Annual South Carolina Alliance for Cancer Chemoprevention Symposium |
Selected Publications
Peer-Reviewed Articles
- Cao WM, Zheng YB, Gao Y, Ding XW, Sun Y, Huang Y, Lou CJ, Pan ZW, Peng G, Wang XJ. Comprehensive mutation detection of BRCA1/2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese women. BMC Cancer 19(1):551, 2019. e-Pub 2019. PMID: 31174498.
- Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell 35(6):851-867.e7, 2019. PMID: 31185210.
- Shen J, Zhao W, Ju Z, Wang L, Peng Y, Labrie M, Yap TA, Mills GB, Peng G. PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness. Cancer Res 79(2):311-319, 2019. e-Pub 2018. PMID: 30482774.
- Yu Y, Pham N, Xia B, Papusha A, Wang G, Yan Z, Peng G, Chen K, Ira G. Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks. Nature 564(7735):287-290, 2018. e-Pub 2018. PMID: 30518856.
- Hsieh HJ, Zhang W, Lin SH, Yang WH, Wang JZ, Shen J, Zhang Y, Lu Y, Wang H, Yu J, Mills GB, Peng G . Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nat Commun 9(1):3982, 2018. e-Pub 2018. PMID: 30266942.
- Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G . ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nature Medicine 24(5):556-562, 2018. e-Pub 2018. PMID: 29736026.
- Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell 33(3):401-416.e8, 2018. PMID: 29533782.
- Zhang L, Peng Y, Peng G. Mismatch repair-based stratification for immune checkpoint blockade therapy. Am J Cancer Res 8(10):1977-1988, 2018. e-Pub 2018. PMID: 30416850.
- Wang C, Zou J, Ma X, Wang E, Peng G. Mechanisms and implications of ADAR-mediated RNA editing in cancer. Cancer Lett 411:27-34, 2017. e-Pub 2017. PMID: 28974449.
- Zhang L, Peng Y, Uray IP, Shen J, Wang L, Peng X, Brown PH, Tu W, Peng G. Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy. DNA Repair (Amst) 60:89-101, 2017. e-Pub 2017. PMID: 29112893.
- Luo CW, Wang JY, Hung WC, Peng G, Tsai YL, Chang TM, Chai CY, Lin CH, Pan MR. G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response. Radiother Oncol 124(3):395-402, 2017. e-Pub 2017. PMID: 28351524.
- Zhang L, Shen J, Yin Y, Peng Y, Wang L, Hsieh HJ, Shen Q, Brown PH, Tao K, Uray IP, Peng G. Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening. SLAS Discov 22(7):813-826, 2017. e-Pub 2017. PMID: 28297605.
- Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med 9(392), 2017. PMID: 28566428.
- Kumar S, Peng X, Daley J, Yang L, Shen J, Nguyen N, Bae G, Niu H, Peng Y, Hsieh HJ, Wang L, Rao C, Stephan CC, Sung P, Ira G, Peng G. Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells. Oncogenesis 6(4):e319, 2017. e-Pub 2017. PMID: 28414320.
- Hsieh HJ, Peng G. Cellular responses to replication stress: implications in cancer biology and therapy. DNA Repair (Amst) 49:9-20, 2017. e-Pub 2016. PMID: 27908669.
- Peng Y, Scott P, Tao R, Wang H, Wu Y, Peng G. Dissect the Dynamic Molecular Circuits of Cell Cycle Control through Network Evolution Model. Biomed Res Int 2017:2954351, 2017. e-Pub 2017. PMID: 28466007.
- Yin Y, Shen Q, Zhang P, Tao R, Chang W, Li R, Xie G, Liu W, Zhang L, Kapoor P, Song S, Ajani J, Mills GB, Chen J, Tao K, Peng G. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res 7(3):473-483, 2017. e-Pub 2017. PMID: 28401005.
- Zou J, Wang C, Ma X, Wang E, Peng G. APOBEC3B, a molecular driver of mutagenesis in human cancers. Cell Biosci 7:29, 2017. e-Pub 2017. PMID: 28572915.
- Mo W, Liu Q, Lin CC, Dai H, Peng Y, Liang Y, Peng G, Meric-Bernstam F, Mills GB, Li K, Lin SY. mTOR inhibitors suppress homologous recombination repair and synergize with PARP inhibitors via regulating SUV39H1 in BRCA-proficient triple-negative breast cancer. Clin Cancer Res 22(7):1699-712, 2016. e-Pub 2015. PMID: 26546619.
- Huang SJ, Tu, W, Ju ZL, Poage GM, Cai CR, Brewster A, Lin SY, Mills GB, Wang H, Peng G. A five-gene signature inferred from transcriptome profiling of homologous recombinant-mediated DNA repair predicts clinical outcome of patients with cancer. Jacobs Journal of Biomarkers 2(1):014, 2016.
- Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol 17(9):1158-68, 2015. e-Pub 2015. PMID: 26237645.
- Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov 5(7):752-67, 2015. e-Pub 2015. PMID: 26069190.
- Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Mol Cell 58(5):863-9, 2015. e-Pub 2015. PMID: 25959398.
- Garrison JB, Ge C, Che L, Pullum DA, Peng G, Khan S, Ben-Jonathan N, Wang J, Du C. Knockdown of the inhibitor of apoptosis BRUCE sensitizes resistant breast cancer cells to chemotherapeutic agents. J Cancer Sci Ther 7(4):121-126, 2015. PMID: 26191375.
- Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes Dev 29(6):591-602, 2015. PMID: 25792597.
- Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25(2):225-36, 2015. e-Pub 2015. PMID: 25601159.
- Zhang C, Peng G. Non-coding RNAs: an emerging player in DNA damage response. Mutat Res Rev Mutat Res 763:202-211, 2015. e-Pub 2014. PMID: 25795121.
- Liang J, Xu ZX, Ding Z, Lu Y, Yu Q, Werle KD, Zhou G, Park YY, Peng G, Gambello MJ, Mills GB. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat Commun 14(6):7926, 2015. e-Pub 2015. PMID: 26272043.
- Peng Y, Dai H, Wang E, Lin CC, Mo W, Peng G, Lin SY. TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. Cancer Res 75(2):378-86, 2015. e-Pub 2014. PMID: 25480944.
- Zhang B, Wang E, Dai H, Shen J, Hsieh HJ, Lu X, Peng G. Phosphorylation of BRCT-Repeat Inhibitor of hTERT (BRIT1) Coordinates TopBP1 Recruitment and Amplifies ATR Signaling. J Biol Chem 289(49):34284-95, 2014. e-Pub 2014. PMID: 25301947.
- Peng G*, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash S, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5:3361, 2014. PMID: 24553445.
- Zhang Y, Wang H, Peng G. Identification of key links in the DNA repair network regulated by tumor suppressors PTEN and BRCA1 through maximum flow analysis. Far East Journal of Mathematical Sciences (FJMS) Special Volume 2013(Part VI):577-586, 2013.
- Zhang B, Wang E, Dai H, Hu R, Liang Y, Li K, Wang G, Peng G*, Lin SY. BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer. Carcinogenesis 34(10):2271-80, 2013. e-Pub 2013. PMID: 23729656.
- Meng L, Lin T, Peng G, Hsu JK, Lee S, Lin SY, Tsai RY. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A 110(28):11415-20, 2013. e-Pub 2013. PMID: 23798389.
- Hu R, Wang E, Peng G, Dai H, Lin SY. Zinc Finger Protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle 12(13):2033-41, 2013. e-Pub 2013. PMID: 23777805.
- Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep 3(6):2100-12, 2013. e-Pub 2013. PMID: 23791529.
- Wan G, Mathur R, Hu X, Liu Y, Zhang X, Peng G, Lu X. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cell Signal 25(5):1086-95, 2013. e-Pub 2013. PMID: 23416462.
- Wang H, Peng G. Mathematical Model of Dynamic Protein Interactions Regulating p53 Protein Stability for Tumor Suppression. Comput Math Methods Med 2013:358980, 2013. e-Pub 2013. PMID: 24454532.
- Park YY, Jung SY, Jennings NB, Rodriguez-Aguayo C, Peng G, Lee SR, Kim SB, Kim K, Leem SH, Lin SY, Lopez-Berestein G, Sood AK, Lee JS. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis 33(10):1843-53, 2012. e-Pub 2012. PMID: 22581827.
- Peng G*, Dai H, Zhang W, Hsieh HJ, Pan MR, Park YY, Tsai RY, Bedrosian I, Lee JS, Ira G, Lin SY. Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res 72(11):2802-13, 2012. e-Pub 2012. PMID: 22491672.
- Pan MR, Hsieh HJ, Dai H, Hung WC, Li K, Peng G*, Lin SY. Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair and its deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem 287(9):6764-72, 2012. e-Pub 2012. PMID: 22219182.
- Hu R, Peng G, Dai H, Breuer EK, Stemke-Hale K, Li K, Gonzalez-Angulo AM, Mills GB, Lin SY. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res 71(20):6524-6534, 2011. e-Pub 2011. PMID: 21852383.
- Zhang W, Peng G, Lin SY, Zhang P. DNA damage response is suppressed by high CDK1 activity in mitotic mammalian cells. J Biol Chem 286(41):35899-905, 2011. e-Pub 2011. PMID: 21878640.
- Pan MR, Peng G*, Hung WC, Lin SY. Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling. J Biol Chem 286(32):28599-607, 2011. e-Pub 2011. PMID: 21676867.
- Tian L, Peng G, Parant JM, Leventaki V, Drakos E, Zhang Q, Parker-Thornburg J, Shackleford TJ, Dai H, Lin SY, Lozano G, Rassidakis GZ, Claret FX. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene 29(46):6125-37, 2010. e-Pub 2010. PMID: 20802511.
- Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res 70(14):6026-35, 2010. e-Pub 2010. PMID: 20587522.
- Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet 6(1):e1000826, 2010. e-Pub 2010. PMID: 20107607.
- Peng G, Lin SY. BRIT1/MCPH1 is a multifunctional DNA damage responsive protein mediating DNA repair-associated chromatin remodeling. Cell Cycle 8(19):3071-2, 2009. e-Pub 2009. PMID: 19755841.
- Peng G, Lin SY. The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1. Epigenetics 4(7):457-61, 2009. e-Pub 2009. PMID: 19829069.
- Peng G, Yim EK, Dai H, Jackson AP, Burgt Iv, Pan MR, Hu R, Li K, Lin SY. BRIT1/MCPH1 links chromatin remodeling to DNA damage response. Nat Cell Biol 11(7):865-72, 2009. e-Pub 2009. PMID: 19525936.
- Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15(4):304-14, 2009. PMID: 19345329.
- Rai R, Peng G, Li K, Lin SY. DNA damage response: the players, the network and the role in tumor suppression. Cancer Genomics Proteomics 4(2):99-106, 2007. PMID: 17804872.
- Peng G, Wargovich MJ, Dixon DA. Anti-proliferative effects of green tea polyphenol EGCG on Ha-Ras-induced transformation of intestinal epithelial cells. Cancer Lett 238(2):260-70, 2006. e-Pub 2005. PMID: 16157446.
- Peng G, Dixon DA, Muga SJ, Smith TJ, Wargovich MJ. Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Mol Carcinog 45(5):309-19, 2006. PMID: 16508969.
- Yoon A, Peng G*, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D. Impairments in IRES-mediated translational control underlie X-linked dyskeratosis congenita. Science 312(5775):902-906, 2006. PMID: 16690864.
- Wang R, Song S, Harada K, Ghazanfari Amlashi F, Badgwell B, Pizzi MP, Xu Y, Zhao W, Dong X, Jin J, Wang Y, Scott A, Ma L, Huo L, Vicente D, Blum Murphy M, Shanbhag N, Tatlonghari G, Thomas I, Rogers J, Kobayashi M, Vykoukal J, Estrella JS, Roy-Chowdhuri S, Han G, Zhang S, Mao X, Song X, Zhang J, Gu J, Johnson RL, Calin GA, Peng G, Lee JS, Hanash SM, Futreal A, Wang Z, Wang L, Ajani JA. Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response. Gut. e-Pub 2019. PMID: 31171626.
- Wang B, Thapa S, Zhou T, Liu H, Li L, Peng G, Yu S. Cancer-related fatigue and biochemical parameters among cancer patients with different stages of sarcopenia. Support Care Cancer. e-Pub 2019. PMID: 31102055.
- Park YY, Yun Jung S, Jennings NB, Rodriguez-Aguayo C, Peng G, Lee SR, Bae Kim S, Kim K, Leem SH, Lin SY, Lopez-Berestein G, Sood AK, Lee JS. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis. e-Pub 2019. PMID: 31063534.
- Yin Y, Liu W, Shen Q, Zhang P, Wang L, Tao R, Li H, Ma X, Zeng X, Cheong JH, Song S, Ajani JA, Mills GB, Tao K, Peng G. The DNA endonuclease Mus81 regulates ZEB1 expression and serves as a target of BET4 inhibitors in gastric cancer. Mol Cancer Ther. e-Pub 2019. PMID: 31142662.
- Lin T, Lin TC, McGrail DJ, Bhupal PK, Ku YH, Zhang W, Meng L, Lin SY, Peng G, Tsai RYL. Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression. Oncogene. e-Pub 2019. PMID: 30692636.
- Chang L, Shen L, Zhou H, Gao J, Pan H, Zheng L, Armstrong B, Peng Y, Peng G, Zhou BP, Rosen ST, Shen B. ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response. Nucleic Acids Res. e-Pub 2018. PMID: 30517763.
- Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. e-Pub 2018. PMID: 29632342.
- Peng G, Mills GB. Surviving ovarian cancer: an affair between defective DNA repair and RB1. Clin Cancer Res. e-Pub 2017. PMID: 29191971.
Invited Articles
- Tu W, Wang H, Peng G. Synthetic lethality as a promising approach for targeted cancer prevention. Cancer and Clinical Research 2(a15), 2014.
Editorials
- Peng G, Woodman SE, Mills GB. RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?. Cancer Discov 4(9):988-90, 2014. PMID: 25185187.
- Peng G, Lin SY. Exploiting the homologous recombination DNA repair network for targeted cancer therapy. World J Clin Oncol 2(2):73-79, 2011. PMID: 21603316.
Abstracts
- Peng G, Hsieh H-J, Mills GB. Mathematical modeling reveals that G2/M checkpoint override creates a therapeutic vulnerability in mTOR-hyperactivated cancer. 2nd Exploring DNA repair pathways as targets for cancer therapy conference, Cancun, Mexico, 2017.
- Peng G. Systems biology approaches to understand and target the DNA repair network. European Environmental Mutagenesis and Genomic Society 44th Annual Meeting, 2015, Prague, Czech Republic, 2015.
- Wang E, Zhang B, Dai H, Lu X, Peng G. BRIT1 promotes ATR signaling through TOPBP1 recruitment to DNA repair sites. Cold Spring Harbor Laboratory, The Cell Cycle, 2014, New York City, NY, 2014.
- Peng G. Targeting cellular survival responses to replication stress as a novel approach for cancer prevention. AACR/JCA Joint Conference: Breakthrough in Basic and Translational Cancer Research, Maui, HI, 2013.
- Peng G, Mo W, Mills G B, Lin S-Y. Gene signature to predict homologous recombination-mediated DNA repair deficiency. Keystone Joint Symposia: Genomic Instability and DNA repair, DNA replication and recombination, Banff, Alberta Canada, 2013.
- Peng G, Mo W, Mills G B, Lin S-Y. A gene signature that predicts deficiency of homologous recombination DNA repair. Late breaking abstract. AACR Annual Meeting, Washington DC, 2013.
- Peng G. Targeting cellular survival responses to genomic instability in cancer. Society of Chinese Bioscientists in America the 14th International Symposium, Xi’an, China, 2013.
- Peng G. A molecular portrait of the homologous recombination DNA repair network via genome-wide transcriptome profiling. SCBA Satellite Meeting Genomic and Epigenomic Instability: Causes and Survival Mechanisms of Cancer, Nanjing, China, 2013.
- Peng G, Mills G, Lin S-Y. A molecular portrait of the homologous recombination DNA repair network via genome-wide transcriptome profiling. 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine, Crete, Greece, 2013.
- Peng G. Targeting cellular survival responses to replication stress in cancer. 3rd World Congress on Cancer Science & Therapy San Francisco, CA, 2013.
- Pan M-R, Lin S-Y, Peng G. Chromatin remodeling as a new target for cancer chemoprevention. Frontiers in Cancer Prevention Research, Boston, MA, 2011.
- Peng G, Lin S-Y. BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response. DLDCC Molecular Carcinogenesis/Cancer Biology Program Symposium, 2010.
- Peng G, Lin S-Y. The Role of BRIT1 in Genome Maintenance and Cancer Suppression. International Cancer Biology Symposium, Taiwan, 2010.
- Peng G, Lin S-Y. BRIT1/MCPH1 links chromatin remodeling to DNA damage response. Genetic Instability and Cancer Symposium, Houston,, 2009.
- Peng G, Lin S-Y. BRIT1/MCPH1 links chromatin remodeling to DNA damage response. The 2nd Meeting on Cellular Responses to DNA Damage, Boston, MA,, 2008.
- Peng G, Lin S-Y. The role of BRIT1/MCpH1 in chromatin remodeling and DNA damage response. DNA Replication and Genomic Integrity Meeting 2008, San Diego, CA,, 2008.
- Lin S-Y, Peng G. The role of BRIT1/MCpH1 in chromatin remodeling and DNA damage response. Maintenance of Genomic Stability Conference, Mexico, 2008.
- Peng G, Lin S-Y. The role of BRIT1/MCPH1 in chromatin remodeling, DNA damage response, and cancer. 8th International Conference of Anticancer Research, 2008.
- Peng G, Wargovich MJ. Green tea polyphenol EGCG inhibits COX-2 expression in human colon cancer cells. AACR meeting, 2005.
- Peng G, Wargovich MJ. Chemopreventive effects of green tea on COX-2 expression in human colon cancer cells. AACR meeting, 2004.
Book Chapters
- Peng G, Lin S-Y.. Emerging roles of BRIT1/MCPH1 in genome maintenance and tumor suppression. In: Tumor Suppressor. Nova Publishers: New York, 2011.
- Peng G, Lin S-Y. A Novel DNA Damage Responsive Protein Dysfunctioned in Primary Microcephaly and Cancer. In: New Research on DNA Damage. Nova Publishers: New York, 99-112, 2008.
Grant & Contract Support
| Title: | Preclinical PREVENT Cancer Program: Cancer Prevention by alpha-Enolase Vaccination |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Preclinical PREVENT Cancer Program: Targeting the mTOR Pathway for the Prevention of Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Preclinical PREVENT Cancer Program: Targeting the RXR Pathway for the Prevention of Triple Negative Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Targeting SOX9 to Prevent Triple-negative Breast Cancer Metastasis |
| Funding Source: | Breast Cancer Research Foundation (BCRF) |
| Role: | Co-Investigator |
| Title: | Targeting a Master Regulator of Metastasis for Treatment of Triple Negative Breast Cancer |
| Funding Source: | Breast Cancer Research Foundation (BCRF) |
| Role: | Co-Investigator |