
Guilin Tang, M.D., Ph.D., FACMG
Department of Hematopathology, Division of Pathology-Lab Medicine Div
About Dr. Tang
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Hematopathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Section Chief, Clinical Cytogenetics, Department of Clinical Cytogenetic Laboratory, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Medical Director, Department of School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
1998 | Hunan Medical University, Changsha, CHN, PHD, Infectious Disease |
1994 | Hunan Medical University, Changsha, CHN, MA, Infectious Disease |
1989 | Hunan Medical University, Changsha, CHN, MD, Medicine |
Postgraduate Training
2012-2013 | Clinical Fellowship, Cytogenetics, Baylor College of Medicine, Houston, TX |
2010-2012 | Clinical Fellowship, Hematopathology, UT MD Anderson Cancer Center, Houston, TX |
2006-2010 | Clinical Residency, Anatomic and Clinical Pathology, University of Massachusetts, Worcester, MA |
2000-2002 | Research Associate, Ben May Institute for Cancer Research, University of Chicago, Chicago, IL |
Board Certifications
2015 | Clinical Cytogenetics |
2011 | Hematopathology |
2010 | Anatomic Pathology |
2010 | Clinical Pathology |
Experience & Service
Academic Appointments
Assistant Professor, Hunan Medical University, Changsha, 1998 - 2000
Other Appointments/Responsibilities
Research Scientist, Department of Oncology, Sanofi-Aventis, Bridgewater, NJ, 2002 - 2006
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Ok CY, Medeiros LJ, Thakral B, Tang G, Jain N, Jabbour E, Pierce SA, Konoplev S. High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma. Mod Pathol, 2018. e-Pub 2018. PMID: 30181564.
- Huang W, Medeiros LJ, Lin P, Wang W, Tang G, Khoury J, Konoplev S, Yin CC, Xu J, Oki Y, Li S.. MYC/BCL2/BCL6 triple hit lymphoma: a study of 40 patients with a comparison to MYC/BCL2 and MYC/BCL6 double hit lymphomas. Mod Pathol, 2018. e-Pub 2018. PMID: 29785017.
- Ok CY1, Loghavi S2, Sui D3, Wei P3, Kanagal-Shamanna R2, Yin CC2, Zuo Z2, Routbort MJ2, Tang G2, Tang Z2, Jorgensen JL2, Luthra R2, Ravandi F4, Kantarjian HM4, DiNardo CD4, Medeiros LJ2, Wang SA2, Patel KP2. Persistent IDH1/2 mutation in remission can predict relapse in patients with acute myeloid leukemia. Haematologica, 2018. e-Pub 2018. PMID: 30171025.
- Garces S, Khoury JD, Kanagal-Shamanna R, Salem A, Wang SA, Ok CY, Hu S, Patel KP, Routbort MJ, Luthra R, Tang G, Schlette EJ, Bueso-Ramos CE, Medeiros LJ, Loghavi S. Chronic lymphocytic leukemia with proliferation centers in bone marrow is associated with younger age at initial presentation, complex karyotype and TP53 disruption. Hum Pathol, 2018. e-Pub 2018. PMID: 30086334.
- Liu H, Wang SA, Schlette EJ, Xu J, Jorgensen JL, Cameron Yin C, Li S, Jeffrey Medeiros L, Tang G.. Myeloid neoplasms with t(16;21)(q24;q22)/RUNX1-RUNX1T3 mimics acute myeloid leukemia with RUNX1-RUNX1T1. Ann Hematol, 2018. e-Pub 2018. PMID: 29872884.
- Boddu PC, Wang SA, Pemmaraju N, Tang Z, Hu S, Li S, Xu J, Medeiros LJ, Tang G. 8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms. Leuk Res 66:73-78, 2018. e-Pub 2018. PMID: 29407586.
- Xu J, Medeiros LJ, Saksena A, Zhou J, Li J, Yin CC, Tang G, Lin P, Li S. CD10-Positive Mantle Cell Lymphoma: Clinicopathologic and Prognostic Study of 30 Cases. Oncotarget 9(14):11441-11450, 2018. e-Pub 2017. PMID: 29545910.
- Hu Z, Sun Y, Schlette E, Tang G, Li S, Xu J, Yin CC, Young KH, Miranda R, Goswami M, Wang M, Jorgensen JL, Medeiros LJ, Wang SA. CD200 Expression in Mantle Cell Lymphoma Identifies a Unique Subgroup of Patients with Frequent IGHV Mutations, Absence of SOX11 Expression, and an Indolent Clinical Course. Mod Pathol 31(2):327-336, 2018. e-Pub 2018. PMID: 28984300.
- Li J, Xu J, Abruzzo LV, Lu G, Tang G, Li S, You J, Jabbour EJ, Deng Q, Bueso-Ramos CE, Medeiros LF, Yin CC. Acute myeloid leukemia with t(4;12)(q12;p13): An aggressive disease with frequent involvement of PDGFRA and ETV6. Oncotarget 9(13):10987-10994, 2017. PMID: 29541391.
- Quesada AE, Medeiros LJ, , Desai PA, Lin P, Westin JR, Hawsawi HM, Wei P, Tang G, Seegmiller AC, Reddy NM, Yin CC, Wang W, Xu J, Miranda RN, Zuo Z, Li S. Increased MYC copy number is an independent prognostic factor in patients with diffuse large B cell lymphoma. Mod Pathol, 2017. e-Pub 2017. PMID: 28776574.
- Showalter JA, Tandon N, Zhao B, Tang G, Nguyen ND, Medeiros LJ. Myeloid sarcoma in a patient with myelodysplastic syndrome associated with del(5q): case report and literature review. Ann Clin Lab Sci. e-Pub 2017. PMID: 28801374.
- Issa GC, Kantarjian HM, Gonzalez GN, Borthakur G, Tang G, Wierda WG, Sasali K, Short NJ, Ravandi-Kashani F, Kadia TM, Patel KP, Luthra R, Ferrajoli A, Garcia-Manero G, Rios M, Dellasala SE, Jabbour E, Cortes JE. Clonal chromosomal abnormalities appearing in Philadelphia negative metaphases during CML treatment. Blood. e-Pub 2017. PMID: 28835440.
- Kanagal-Shamanna R, Jain P, Takahashi K, Short NJ, Tang G, Issa GC, Ravandi F, Garcia-Manero G, Yin CC, Luthra R, Patel KP, Khoury JD, Montalban-Bravo G, Sasaki K, Kadia TM, Borthakur G, Konopleva M, Jain N, Garris R, Pierce S, Wierda W, Estrov Z, Cortes J, O’Brien S, Kantarjian H, Jabbour E.. TP53 mutation does not confer a poor outcome in adult all treated with frontline hyper-CVAD-based regimens. Cancer, 2017. e-Pub 2017. PMID: 28608976.
- Tang Z, Xu J, Wang SA, Li S, Young KH, Medeiros LJ, Tang G. Acquisition of t(2;18)(p11.2;q21.3) and NOTCH1 mutations May Accelerate Richter’s Transformation in Chronic Lymphocytic Leukemia with t(14;19)(q32;q13) and Trisomy 12. Translational Genetics and Genomics. e-Pub 2017.
- Hu Z, Medeiros LJ, Fang L, Sun Y, Tang Z, Tang G, Sun T, Quesada AE, Hu S, Wang SA, Pei L, Lu X. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. Am J Hematol 92(5):441-447, 2017. e-Pub 2017. PMID: 28194886.
- Tang G, Hidalgo Lopez JE, Wang SA, Hu S, Bassett R, Ma J, Pierce S, Zuo W, Carballo-Zarate AJ, Yin CC, Tang Z, Li S, Medeiros LJ, Verstovsek S, Bueso-Ramos CE. Characteristics and clinical significance of cytogenetic abnormalities in polycythemia vera. Haematologica. e-Pub 2017. PMID: 28473622.
- Ballester LY, Huse JT, Tang G, Fuller GN. Molecular Classification of Adult Diffuse Gliomas: Conflicting IDH1/IDH2, ATRX and 1p/19q Results. Human Pathology, 2017. e-Pub 2017. PMID: 28549927.
- Montenegro-Garreaud X, Miranda RN, Reynolds A, Tang G, Wang SA, Yabe M, Wang W, Fang L, Bueso-Ramos CE, Lin P, Medeiros LJ, Lu X. Myeloproliferative Neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: A Meta-Analysis of 20 Cases Shows Cytogenetic Progression with B-Lymphoid Blast Phase. Human Pathology, 2017. e-Pub 2017. PMID: 28551329.
- Gur HD, Wang SA, Tang Z, Hu S, Li S, Medeiros LJ, Tang G. Clinical significance of isolated del(7p) in myeloid neoplasms. Leuk Res 55:18-22, 2017. e-Pub 2017. PMID: 28119224.
- Thakral B, Medeiros LJ, Desai P, Lin P, Yin CC, Tang G, Khoury JD, Hu S, Xu J, Loghavi S, Hu B, Oki Y, Li S. Prognostic impact of CD5 expression in diffuse large B-cell lymphoma in patients treated with rituximab-EPOCH. Eur J Haematol 98(4):415-421, 2017. e-Pub 2017. PMID: 28039906.
- Rogers HJ, Hsi ED, Tang G, Wang SA, Bueso-Ramos CE, Lubin D, Morrissette JJ, Bagg A, Cherukuri DP, George TI, Peterson L, Liu YC, Mathew S, Orazi A, Hasserjian RP. Most Myeloid Neoplasms With Deletion of Chromosome 16q Are Distinct From Acute Myeloid Leukemia With Inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study. Am J Clin Pathol 147(4):411-419, 2017. PMID: 28375434.
- Salem A, Loghavi S, Tang G, Huh YO, Jabbour EJ, Kantarjian H, Wang W, Hu S, Luthra R, Medeiros LJ, Khoury JD. Myeloid neoplasms with concurrent BCR-ABL1 and CBFB rearrangements: A series of 10 cases of a clinically aggressive neoplasm. Am J Hematol. e-Pub 2017. PMID: 28253536.
- Hu Z, Medeiros LJ, Wang W, Chen Z, Tang G, Hodjat P, Yang S, Fang L, Li Y, Verstovsek S, Hu S. 3q26.2/EVI1 rearrangement is associated with poor prognosis in classical Philadelphia chromosome-negative myeloproliferative neoplasms. Mod Pathol. e-Pub 2017. PMID: 28338652.
- Gong Z, Zheng L, Tang Z, Chen Z, Wang W, Bai S, Tang G, Jeffrey Medeiros L, Hu S. Role of complexity of variant Philadelphia chromosome in chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Ann Hematol 96(3):501-504, 2017. e-Pub 2016. PMID: 27915425.
- Zuo W, Wang SA, DiNardo C, Yabe M, Li S, Medeiros LJ, Tang G. Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene. J Clin Pathol 70(3):244-249, 2017. e-Pub 2016. PMID: 27496968.
- Huang L, Wang SA, DiNardo C, Li S, Hu S, Xu J, Zhou W, Goswami M, Medeiros LJ, Tang G. Tetraploidy/near-tetraploidy acute myeloid leukemia. Leuk Res 53:20-27, 2017. e-Pub 2016. PMID: 27951415.
- Xu J, Oki Y, Saksena A, Desai P, Lin P, Tang G, Yin CC, You MJ, Thakral B, Medeiros LJ, Li S. CD30 expression and prognostic significance in R-EPOCH-treated patients with diffuse large B-cell lymphoma. Hum Pathol 60:160-166, 2017. e-Pub 2016. PMID: 27816715.
- Wang XJ, L Jeffrey Medeiros , Bueso-Ramos CE, Tang G, Wang S, Oki Y, Desai P, Khoury JD, Miranda RN, Tang Z, Reddy N, Li S. P53 expression correlates with poorer survival and augments the negative prognostic effect of MYC rearrangement, expression or concurrent MYC/BCL2 expression in diffuse large B-cell lymphoma. Mod Pathol 30(2):194-203, 2017. e-Pub 2016. PMID: 27739436.
- Yabe M, Medeiros LJ, Wang SA, Tang G, Bueso-Ramos CE, Jorgensen JL, Bhagat G, Chen W, Li S, Young KH, Miranda RN. Distinguishing Between Hepatosplenic T-cell Lymphoma and γδ T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. Am J Surg Pathol 41(1):82-93, 2017. PMID: 27755009.
- Tang G, Bueso-Ramos CE, Li S, Medeiros LJ, Wang SA. Acquired 11q23/MLL rearrangement of unknown clinical significance. Int J Clin Exp Pathol 10(8):9048-9051, 2017. e-Pub 2017.
- Gong Z, Medeiros LJ, Cortes JE, Zheng L, Khoury JD, Wang W, Tang G, Loghavi S, Luthra R, Yang W, Kantarjian HM, Hu S. Clinical and Prognostic Significance of e1a2 BCR-ABL1 Transcript Subtype in Patients with Chronic Myeloid Leukemia. Blood Cancer Journal 7(7), 2017. e-Pub 2017. PMID: 28708130.
- Sun Y, Tang G, Hu Z, Thakral B, Medeiros LJ, Wang SA. Comparison of Karyotyping, TCL1 Fluorescence in situ Hybridization and TCL1 Immunohistochemistry in T-cell Prolymphocytic Leukemia. J Clin Pathol, 2017. e-Pub 2017. PMID: 28821581.
- Boddu P, Schlette E, Thakral B, Tang G, Pemmaraju N, Kadia P, Ferrajoli A, Ravandi F, Wierda W, Jain N. Acute Promyelocytic Leukemia in a Patient with Chronic Lymphocytic Leukemia – A Case Report. Hematology/Oncology and Stem cell Therapy, 2017. e-Pub 2017. PMID: 28830803.
- Boddu P, Yin CC, Kanagala R, Tang G, Thakral B, Kadia T, Konopleva M, Jabbour E, Jain N. An unsuspected finding of t(9;22): a rare case of Philadelphia chromosome-positive B-lymphoblastic lymphoma. Case Reports in Hematology, 2017. e-Pub 2017. PMID: 29075538.
- Tang Z, Li Y, Wang SA, Hu S, Li S, Lu X, Khoury JD, Medeiros LJ, Tang G. Clinical significance of acquired loss of the X chromosome in bone marrow. Leuk Res 47:109-13, 2016. e-Pub 2016. PMID: 27299973.
- Zhou Y, Kanagal-Shamanna R, Zuo Z, Tang G, Medeiros LJ, Bueso-Ramos CE. Advances in B-lymphoblastic leukemia: cytogenetic and genomic lesions. Ann Diagn Pathol 23:43-50, 2016. e-Pub 2016. PMID: 27130145.
- Huh YO, Tang G, Talwalkar SS, Khoury JD, Ohanian M, Bueso-Ramos CE, Abruzzo LV. Double minute chromosomes in acute myeloid leukemia, myelodysplastic syndromes, and chronic myelomonocytic leukemia are associated with micronuclei, MYC or MLL amplification, and complex karyotype. Cancer Genet 209(7-8):313-20, 2016. e-Pub 2016. PMID: 27318442.
- Goswami RS, Wang SA, DiNardo C, Tang Z, Li Y, Zuo W, Hu S, Li S, Medeiros LJ, Tang G. Newly emerged isolated Del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasms. Mod Pathol 29(7):727-34, 2016. e-Pub 2016. PMID: 27056073.
- Wang W, Tang G, Kadia T, Lu X, Li Y, Huang L, Montenegro-Garreaud X, Miranda RN, Wang SA. Cytogenetic Evolution Associated With Disease Progression in Hematopoietic Neoplasms With t(8;22)(p11;q11)/BCR-FGFR1 Rearrangement. J Natl Compr Canc Netw 14(6):708-11, 2016. PMID: 27283163.
- Li S, Saksena A, Desai P, Xu J, Zuo Z, Lin P, Tang G, Yin CC, Seegmiller A, Jorgensen JL, Miranda RN, Reddy NM, Bueso-Ramos C, Medeiros LJ. Prognostic impact of history of follicular lymphoma, induction regimen and stem cell transplant in patients with MYC/BCL2 double hit lymphoma. Oncotarget 7(25):38122-38132, 2016. PMID: 27203548.
- Wang W, Cortes JE, Tang G, Khoury JD, Wang S, Bueso-Ramos CE, DiGiuseppe JA, Chen Z, Kantarjian HM, Medeiros LJ, Hu S. Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood 127(22):2742-50, 2016. e-Pub 2016. PMID: 27006386.
- Ouyang J, Goswami M, Peng J, Zuo Z, Daver N, Borthakur G, Tang G, Medeiros LJ, Jorgensen JL, Ravandi F, Wang SA. Comparison of Multiparameter Flow Cytometry Immunophenotypic Analysis and Quantitative RT-PCR for the Detection of Minimal Residual Disease of Core Binding Factor Acute Myeloid Leukemia. Am J Clin Pathol 145(6):769-77, 2016. e-Pub 2016. PMID: 27298396.
- Jain P, Tang G, Huh YO, Yin CC, Zuo Z, Pemmaraju N, Estrov Z, Daver N. Philadelphia-positive dimorphic blasts in mixed-phenotype acute leukemia with TET2 mutation. Am J Hematol 91(6):647-8, 2016. e-Pub 2016. PMID: 26799924.
- Li S, Desai P, Lin P, Yin CC, Tang G, Wang XJ, Konoplev SN, Khoury JD, Bueso-Ramos CE, Medeiros LJ. MYC/BCL6 double-hit lymphoma (DHL): a tumour associated with an aggressive clinical course and poor prognosis. Histopathology 68(7):1090-8, 2016. e-Pub 2015. PMID: 26426741.
- Li Y, Hu S, Wang SA, Li S, Huh YO, Tang Z, Medeiros LJ, Tang G. The clinical significance of 8q24/MYC rearrangement in chronic lymphocytic leukemia. Mod Pathol 29(5):444-51, 2016. e-Pub 2016. PMID: 26916070.
- Yabe M, Medeiros LJ, Tang G, Wang SA, Ahmed S, Nieto Y, Hu S, Bhagat G, Oki Y, Patel KP, Routbort M, Luthra R, Fanale MA, Bueso-Ramos CE, Jorgensen JL, Vega F, Chen W, Hoehn D, Konoplev S, Milton DR, Wistuba I, Li S, You MJ, Young KH, Miranda RN. Prognostic Factors of Hepatosplenic T-cell Lymphoma: Clinicopathologic Study of 28 Cases. Am J Surg Pathol 40(5):676-88, 2016. PMID: 26872013.
- Yabe M, Medeiros LJ, Tang G, Wang SA, P Patel K, Routbort M, Bhagat G, Bueso-Ramos CE, Jorgensen JL, Luthra R, Chen W, Muzzafar T, Kanagal-Shamanna R, Khoury JD, Daneshbod Y, Davanlou M, Li S, Young KH, Miranda RN. Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients. Hum Pathol 50:109-17, 2016. e-Pub 2015. PMID: 26997444.
- Jain P, Tang G, Konoplev SN, Kanagal-Shamanna R, Wang SA, Pemmaraju N, Daver N, Estrov Z. Synchronous del5q myelodysplastic syndrome (del5qMDS) and adult B-cell acute lymphoblastic leukemia (B-ALL) with TET2 and TP53 mutations. Am J Hematol 91(3):354-5, 2016. e-Pub 2016. PMID: 26437693.
- Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell Lymphoma With MYC Rearrangement and Without BCL2 and BCL6 Rearrangements Is Associated With High P53 Expression and a Poor Prognosis. Am J Surg Pathol 40(2):253-61, 2016. PMID: 26448193.
- Tang Z, Medeiros LJ, Yin CC, Wang W, Lu X, Young KH, Khoury JD, Tang G. Sex chromosome loss after allogeneic hematopoietic stem cell transplant in patients with hematologic neoplasms: a diagnostic dilemma for clinical cytogeneticists. Mol Cytogenet 9:62, 2016. e-Pub 2016. PMID: 27508005.
- Tang Z, Tang G, Wang SA, Lu X, Young KH, Bueso-Ramos CE, Alvarado Y, Medeiros LJ, Khoury JD. Simultaneous deletion of 3'ETV6 and 5'EWSR1 genes in blastic plasmacytoid dendritic cell neoplasm: case report and literature review. Mol Cytogenet 9:23, 2016. e-Pub 2016. PMID: 26925167.
- Peng J, Hasserjian RP, Tang G, Patel KP, Goswami M, Jabbour EJ, Garcia-Manero G, Medeiros LJ, Wang SA. Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response. Leuk Lymphoma 57(4):812-9, 2016. e-Pub 2016. PMID: 26293512.
- Sevcikova K, Zhuang Z, Garcia-Manero G, Alvarez RH, Kantarjian HM, Mego M, Albarracin C, Tang G, Strom SS, Medeiros LJ, Hortobagyi GN, Reuben JM, Khoury JD. Comprehensive analysis of factors impacting risks and outcomes of therapy-related myeloid neoplasms following breast cancer treatment. Leukemia 30(1):242-7, 2016. e-Pub 2015. PMID: 25975189.
- Peng J, Zuo Z, Fu B, Oki Y, Tang G, Goswami M, Priyanka P, Muzzafar T, Medeiros LJ, Luthra R, Wang SA. Chronic myelomonocytic leukemia with nucleophosmin (NPM1) mutation. Eur J Haematol 96(1):65-71, 2016. e-Pub 2015. PMID: 25809997.
- Wang W, Cortes JE, Lin P, Khoury JD, Ai D, Tang Z, Tang G, Jorgensen JL, Medeiros LJ, Hu S. Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in the era of tyrosine kinase inhibitors. Leukemia 29(11):2263-6, 2015. e-Pub 2015. PMID: 25931274.
- Liu H, Wang W, Tang G, Yin CC, Muzzafar T, Medeiros LJ, Hu S. Lymphomatous variant of hairy cell leukaemia: a distinctive presentation mimicking low-grade B-cell lymphoma. Histopathology 67(5):740-5, 2015. e-Pub 2015. PMID: 25809821.
- Tang G, Fu B, Hu S, Lu X, Tang Z, Li S, Jabbar K, Khoury JD, Medeiros LJ, Wang SA. Prognostic impact of acquisition of cytogenetic abnormalities during the course of chronic myelomonocytic leukemia. Am J Hematol 90(10):882-7, 2015. e-Pub 2015. PMID: 26148174.
- Sanford D, DiNardo CD, Tang G, Cortes JE, Verstovsek S, Jabbour E, Ravandi F, Kantarjian H, Garcia-Manero G. Jumping Translocations in Myeloid Malignancies Associated With Treatment Resistance and Poor Survival. Clin Lymphoma Myeloma Leuk 15(9):556-62, 2015. e-Pub 2015. PMID: 26141213.
- Yin CC, Peng J, Li Y, Shamanna RK, Muzzafar T, DiNardo C, Khoury JD, Li S, Medeiros LJ, Wang SA, Tang G. Clinical significance of newly emerged isolated del(20q) in patients following cytotoxic therapies. Mod Pathol 28(8):1014-22, 2015. e-Pub 2015. PMID: 26044451.
- Chen Z, Wang W, Rich A, Tang G, Hu S. Myeloid sarcoma as the initial presentation of chronic myelogenous leukemia, medullary chronic phase in era of tyrosine kinase inhibitors: A report of 11 cases. Am J Hematol 90(8):E146-8, 2015. e-Pub 2015. PMID: 25960187.
- Yin CC, Tang G, Lu G, Feng X, Keating MJ, Medeiros LJ, Abruzzo LV. Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells. Mod Pathol 28(8):1130-7, 2015. e-Pub 2015. PMID: 25953391.
- Shen Q, Ouyang J, Tang G, Jabbour EJ, Garcia-Manero G, Routbort M, Konoplev S, Bueso-Ramos C, Medeiros LJ, Jorgensen JL, Wang SA. Flow cytometry immunophenotypic findings in chronic myelomonocytic leukemia and its utility in monitoring treatment response. Eur J Haematol 95(2):168-76, 2015. e-Pub 2015. PMID: 25354960.
- Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ. Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant. Am J Clin Pathol 144(1):78-86, 2015. PMID: 26071464.
- Yabe M, Tang G, Garcia-Manero G, Loghavi S, Lu X, Miranda RN, Medeiros LJ, Kantarjian HM, Bueso-Ramos CE, Khoury JD. Acute Myeloid Leukemia With t(v;5q33) Is Associated With Poor Overall Survival and Often Lacks Myelodysplastic Features. Clin Lymphoma Myeloma Leuk 15 Suppl:S85-90, 2015. PMID: 26297286.
- Loghavi S, Alayed K, Aladily TN, Zuo Z, Ng SB, Tang G, Hu S, Yin CC, Miranda RN, Medeiros LJ, Khoury JD. Stage, age, and EBV status impact outcomes of plasmablastic lymphoma patients: a clinicopathologic analysis of 61 patients. J Hematol Oncol 8:65, 2015. e-Pub 2015. PMID: 26055271.
- Ouyang J, Goswami M, Tang G, Peng J, Ravandi F, Daver N, Routbort M, Konoplev S, Lin P, Medeiros LJ, Jorgensen JL, Wang SA. The clinical significance of negative flow cytometry immunophenotypic results in a morphologically scored positive bone marrow in patients following treatment for acute myeloid leukemia. Am J Hematol 90(6):504-10, 2015. e-Pub 2015. PMID: 25732229.
- Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Peng J, Tang G, Goswami M, Young KH, Singh R, Medeiros LJ, Kantarjian HM, Luthra R, Wang SA. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases. J Hematol Oncol 8:45, 2015. e-Pub 2015. PMID: 25952993.
- Wang W, Tang G, Cortes JE, Liu H, Ai D, Yin CC, Li S, Khoury JD, Bueso-Ramos C, Medeiros LJ, Hu S. Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis. J Hematol Oncol 8:32, 2015. e-Pub 2015. PMID: 25888368.
- Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Fu B, Tang G, Goswami M, Singh R, Kanagal-Shamanna R, Pierce SA, Young KH, Kantarjian HM, Medeiros LJ, Luthra R, Wang SA. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. Leuk Res 39(3):348-54, 2015. e-Pub 2014. PMID: 25573287.
- Liu W, Hu S, Konopleva M, Khoury JD, Kalhor N, Tang G, Bueso-Ramos CE, Jorgensen JL, Lin P, Medeiros LJ, Lu X. De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis. Pediatr Hematol Oncol 32(8):535-47, 2015. e-Pub 2015. PMID: 26558423.
- Gu J, Patel KP, Bai B, Liu CH, Tang G, Kantarjian HM, Tang Z, Abraham R, Luthra R, Medeiros LJ, Lin P, Lu X. Double inv(3)(q21q26.2) in acute myeloid leukemia is resulted from an acquired copy neutral loss of heterozygosity of chromosome 3q and associated with disease progression. Mol Cytogenet 8:68, 2015. e-Pub 2015. PMID: 26300976.
- Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G. Isolated +15 in bone marrow: disease-associated or a benign finding?. Leuk Res 39(1):72-6, 2015. e-Pub 2014. PMID: 25435027.
- Tang G, DiNardo C, Zhang L, Ravandi F, Khoury JD, Huh YO, Muzzafar T, Medeiros LJ, Wang SA, Bueso-Ramos CE. MLL gene amplification in acute myeloid leukemia and myelodysplastic syndromes is associated with characteristic clinicopathological findings and TP53 gene mutation. Hum Pathol 46(1):65-73, 2015. e-Pub 2014. PMID: 25387813.
- DiNardo CD, Tang G, Pemmaraju N, Wang SA, Pike A, Garcia-Manero G, Cortes J, Bueso-Ramos C, Kantarjian HM. Acute myeloid leukemia with t(10;11): a pathological entity with distinct clinical presentation. Clin Lymphoma Myeloma Leuk 15(1):47-51, 2015. e-Pub 2014. PMID: 25081372.
- Tang G, Wang SA, Lu V, Lee HC, Qazilbash MH, Wang XI, Yin CC, Orlowski R, Wang Y, Patel A, Medeiros LJ, Lu G. Clinically silent clonal cytogenetic abnormalities arising in patients treated for lymphoid neoplasms. Leuk Res 38(8):896-900, 2014. e-Pub 2014. PMID: 24939217.
- Tang G, Zhang L, Fu B, Hu J, Lu X, Hu S, Patel A, Goswami M, Khoury JD, Garcia-Manero G, Medeiros LJ, Wang SA. Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institution. Am J Hematol 89(8):813-8, 2014. e-Pub 2014. PMID: 24782398.
- Tang G, Lu X, Wang SA, Roney EK, Zhang L, Hu S, Lu G, Medeiros LJ, Patel A. Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms. Int J Clin Exp Pathol 7(6):3196-201, 2014. e-Pub 2014. PMID: 25031740.
- Tang G, Banks HE, Sargent RL, Medeiros LJ, Abruzzo LV. Chronic lymphocytic leukemia with t(14;18)(q32;q21). Hum Pathol 44(4):598-605, 2013. e-Pub 2012. PMID: 23084581.
- Wang SA, Hutchinson L, Tang G, Chen SS, Miron PM, Huh YO, Jones DM, Bueso-Ramos C, Verstovsek S, Medeiros LJ, Miranda RN. Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components. Am J Hematol 88(3):219-24, 2013. PMID: 23440662.
- Liu D, Lin P, Hu Y, Zhou Y, Tang G, Powers L, Medeiros LJ, Jorgensen JL, Wang SA. Immunophenotypic heterogeneity of normal plasma cells: comparison with minimal residual plasma cell myeloma. J Clin Pathol 65(9):823-9, 2012. e-Pub 2012. PMID: 22685235.
- Tang G, Jorgensen LJ, Zhou Y, Hu Y, Kersh M, Garcia-Manero G, Medeiros LJ, Wang SA. Multi-color CD34 progenitor-focused flow cytometric assay in evaluation of myelodysplastic syndromes in patients with post cancer therapy cytopenia. Leuk Res 36(8):974-81, 2012. e-Pub 2012. PMID: 22626984.
- Tang G, Zuo Z, Thomas DA, Lin P, Liu D, Hu Y, Kantarjian HM, Bueso-Ramos C, Medeiros LJ, Wang SA. Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?. Haematologica 97(6):919-25, 2012. e-Pub 2011. PMID: 22207681.
- Zhou Y, Tang G, Medeiros LJ, McDonnell TJ, Keating MJ, Wierda WG, Wang SA. Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Mod Pathol 25(2):237-45, 2012. e-Pub 2011. PMID: 22080061.
- Tang G, Wang SA, Menon M, Dresser K, Woda BA, Hao S. High-level CD34 expression on megakaryocytes independently predicts an adverse outcome in patients with myelodysplastic syndromes. Leuk Res 35(6):766-70, 2011. e-Pub 2011. PMID: 21367453.
- Hasserjian RP, Zuo Z, Garcia C, Tang G, Kasyan A, Luthra R, Abruzzo LV, Kantarjian HM, Medeiros LJ, Wang SA. Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification. Blood 115(10):1985-92, 2010. e-Pub 2009. PMID: 20040759.
- Tang G, Woods LJ, Wang SA, Brettler D, Andersen M, Miron PM, Pechet L, Woda BA, Hao S. Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm. Hum Pathol 40(8):1194-9, 2009. e-Pub 2009. PMID: 19427022.
- Pozdnyakova O, Miron PM, Tang G, Walter O, Raza A, Woda B, Wang SA. Cytogenetic abnormalities in a series of 1,029 patients with primary myelodysplastic syndromes: a report from the US with a focus on some undefined single chromosomal abnormalities. Cancer 113(12):3331-40, 2008. PMID: 18988232.
- Wang SA, Tang G, Fadare O, Hao S, Raza A, Woda BA, Hasserjian RP. Erythroid-predominant myelodysplastic syndromes: enumeration of blasts from nonerythroid rather than total marrow cells provides superior risk stratification. Mod Pathol 21(11):1394-402, 2008. e-Pub 2008. PMID: 18839018.
- Tang G, Truong F, Fadare O, Woda B, Wang SA. Diagnostic challenges related to myeloid/natural killer cells, a variant of myeloblasts. Int J Clin Exp Pathol 1(6):544-9, 2008. e-Pub 2008. PMID: 18787634.
- Arendt CW, Tang G, Zilberstein A. Vector systems for the delivery of small interfering RNAs: managing the RISC. Chembiochem 4(11):1129-36, 2003. PMID: 14613103.
- Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 22(24):8571-9, 2002. PMID: 12446776.
- Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature 414(6861):313-7, 2001. PMID: 11713531.
- Tang G, Yang J, Minemoto Y, Lin A. Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. Mol Cell 8(5):1005-16, 2001. PMID: 11741536.
- Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A 98(12):6668-73, 2001. e-Pub 2001. PMID: 11381115.
Invited Articles
- Tang G, Medeiros LJ, Wang SA. How I investigate Clonal cytogenetic abnormalities of undetermined significance. Int J Lab Hematol 40(4):385-391, 2018. PMID: 2962489.
Grant & Contract Support
Title: | Faculty Starting Fund |
Funding Source: | MD Anderson Cancer Center |
Role: | Principal Investigator |