Guy Handley, MD
Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Assistant Professor, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2015 | University of Alabama School of Medicine, US, Medicine, Doctor of Medicine |
| 2011 | Rhodes College, US, Biology, Bachelor of Science |
Postgraduate Training
| 2019-2019 | Postgraduate Fellow, Infectious Diseases, McGovern Medical School UT Health/MD Anderson Cancer Center, Houston, Texas |
| 2016-2018 | Residency, Internal Medicine, Ochsner Clinic Foundation |
| 2015-2016 | Internship, Internal Medicine, Ochsner Clinic Foundation |
Experience & Service
Academic Appointments
Assistant Professor, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, 2021 - 2024
Associate Lecturer, Ochsner Clinical School, 2018 - 2021
Administrative Appointments/Responsibilities
Associate Chief Infection Control Officer, Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present
Honors & Awards
| 2024 - Present | Castle Connolly Rising Star, Castle Connolly Rising Star |
| 2023 - Present | Faculty Teacher of the Year Award, USF Health Division of Infectious Disease |
| 2020 - Present | IDWeek 2020 Trainee Award, Infectious Diseases Society of America |
| 2020 - Present | Chief Fellow, McGovern Medical School UT Health |
| 2018 - Present | Chief Medical Resident, Ochsner Clinic Foundation |
| 2017 - Present | Ochsner Clinical School Resident Teaching Award, Ochsner Clinical School |
| 2012 - Present | UAB Department of Medicine Summer Internship Program Award, University of Alabama School of Medicine |
Selected Publications
Peer-Reviewed Articles
- Handley, GH, Yepes, A, Eliassen, E, Dominguez, G, Pasikhova, Y, Klinkova, O, Baluch, A, Febres-Aldana, A, Alsina, M, Elmariah, H, Khimani, F, Hansen, DK, Freeman, C, Jain, MD, Locke, FL, Lazaryan, A, Liu, HD, Mishra, A, Mirza, AS, Nishihori, T, Ochoa, L, Perez, LE, Pidala, J, Castaneda Puglianini, OA, Nieder, M, Perna, F, Kim, J, Bejanyan, N, Faramand, R. Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. Open Forum Infectious Diseases 11(10), 2024. e-Pub 2024. PMID: 39411216.
- Pearson EM, Handley G, Greene J. Concurrent Zoster Sine Herpete and Hepatosplenic Fungal Infection in a Cancer Patient: A Case Report. Cureus 16(10):e72117, 2024. e-Pub 2024. PMID: 39574981.
- Handley G, Yepes A, Eliassen E, Dominguez G, Pasikhova Y, Klinkova O, Baluch A, Febres-Aldana AJ, Alsina M, Elmariah H, Khimani F, Hansen DK, Freeman CL, Jain MD, Locke F, Lazaryan A, Liu HD, Mishra A, Mirza AS, Nishihori T, Ochoa L, Perez L, Pidala J, Puglianini OC, Nieder M, Perna F, Kim J, Bejanyan N, Faramand R. Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. Open Forum Infect Dis 11(10):ofae564, 2024. e-Pub 2024. PMID: 39411216.
- Makovich Z, Radosavljevic I, Chapyala S, Handley G, Pena L, Mok S, Friedman M. Rationale for Hepatitis C Virus Treatment During Hematopoietic Stem Cell Transplant in the Era of Novel Direct-Acting Antivirals. Dig Dis Sci 69(9):3488-3500, 2024. e-Pub 2024. PMID: 38990268.
- Khawaja F, Ahmed S, Iyer SP, Sassine J, Handley G, Prakash R, VanWierren T, Jackson J, Zubovskaia A, Ramdial J, Rondon G, Patel KK, Spallone A, Ariza-Heredia EJ, Mulanovich V, Angelidakis G, Jiang Y, Chemaly RF. Cytomegaloviral Infections in Recipients of Chimeric Antigen Receptor T-Cell Therapy: An Observational Study With Focus on Oncologic Outcomes. Open Forum Infect Dis 11(8):ofae422, 2024. e-Pub 2024. PMID: 39086466.
- Handley, GH, Greene, J, Cannella, AP, Velez, AP, Shah, S, Pasikhova, Y. Real-world Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients. Open Forum Infectious Diseases 11(5), 2024. e-Pub 2024.
- Handley G, Greene J, Cannella AP, Velez AP, Shah S, Pasikhova Y. Real-world Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients: Clinical Implications of Hypoalbuminemia as a Predictor of Subtherapeutic Posaconazole Levels. Open Forum Infect Dis 11(5):ofae185, 2024. e-Pub 2024. PMID: 38680607.
- Kampouri E, Handley G, Hill JA. Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape. Viruses 16(4), 2024. e-Pub 2024. PMID: 38675841.
- Graeter A, Lee D, Handley G, Baluch A, Klinkova O. Chronic disseminated candidiasis in a patient with acute leukemia - an illustrative case and brief review for clinicians. BMC Infect Dis 24(1):296, 2024. e-Pub 2024. PMID: 38448809.
- Lemay, D, Handley, GH, Baluch, A, Greene, JN. Adenovirus Enterocolitis in Hematopoietic Stem Cell Transplant Patients. Infectious Diseases in Clinical Practice 31(1), 2023. e-Pub 2023.
- Velez AP, Handley G, Morison A, Katzman JH, Kinkhova O, Quiltz R, Greene J, Pasikhova Y. Safety and Outcomes With Combination Therapy With Sarilumab and Baricitinib for Severe COVID-19 Respiratory Infection in Cancer Patients. Cancer Control 30:10732748231205864, 2023. e-Pub 2023. PMID: 37817417.
- Emanuel N, Siddique N, Greene J, Pasikhova Y, Morrison A, Ledbetter M, Handley G. Nocardia niwae Disseminated Nocardiosis: A Novel Species Presenting Concurrently With Lung Adenocarcinoma. Cureus 14(11):e31246, 2022. e-Pub 2022. PMID: 36505126.
- Baluch A, Handley G, Ludlow S, Morrison A, Velez A, Rojas MC, Pasikhova Y. Disseminated Toxoplasmosis in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report and Review of the Current Literature. Cureus 14(9):e29185, 2022. e-Pub 2022. PMID: 36259018.
- Handley G. Current Role of Prospective Monitoring and Preemptive and Prophylactic Therapy for Human Herpesvirus 6 After Allogeneic Stem Cell Transplantation. Open Forum Infect Dis 9(8):ofac398, 2022. e-Pub 2022. PMID: 36004309.
- Handley G, Hand J. Adverse Effects of Immunosuppression: Infections. Handb Exp Pharmacol 272:287-314, 2022. e-Pub 2022. PMID: 34671868.
- Handley G, Khawaja F, Kondapi DS, Lee HJ, Kaufman GP, Neelapu SS, Fayad LE, Tummala S, Chi L, Strati P, Mulanovich VE. Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy. Int J Infect Dis 112:327-329, 2021. e-Pub 2021. PMID: 34600133.
- Handley G, Pankow S, Bard JD, Yee R, Nigo M, Hasbun R. Distinguishing cytomegalovirus meningoencephalitis from other viral central nervous system infections. J Clin Virol 142:104936, 2021. e-Pub 2021. PMID: 34352616.
- Handley G, Hasbun R, Okhuysen P. Human herpesvirus 6 and central nervous system disease in oncology patients: A retrospective case series and literature review. J Clin Virol 136:104740, 2021. e-Pub 2021. PMID: 33548682.
- Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, King RW, Xu X, Gaggar A, Bailey WC, Dransfield MT, Blalock JE. A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 192(8):934-42, 2015. e-Pub 2015. PMID: 26151090.
- Wells JM, O'Reilly PJ, Szul T, Sullivan DI, Handley G, Garrett C, McNicholas CM, Roda MA, Miller BE, Tal-Singer R, Gaggar A, Rennard SI, Jackson PL, Blalock JE. An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 190(1):51-61, 2014. e-Pub 2014. PMID: 24874071.
Book Chapters
- Handley, GH. Human Herpesvirus 6A, 6B, 7, and 8 in Hematopoietic Stem Cell Transplant, 189-200, 2024.
- Eatrides, J, Handley, GH. Microorganism-Induced Benign Hematologic Conditions, 715-734, 2024.
- Handley, GH. Epstein-Barr Virus, 167-188, 2024.
- Handley, GH, Hand, J. Adverse Effects of Immunosuppression, 287-314, 2022.
Letters to the Editor
- Handley G, Pasikhova Y, Hill JA. Letter to the Editor Regarding "Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation". Transplant Cell Ther 29: 645-646, 2023.
Patient Reviews
CV information above last modified June 20, 2025