Guy Handley, MD
Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2015 | University of Alabama School of Medicine, US, Medicine, Doctor of Medicine |
| 2011 | Rhodes College, US, Biology, Bachelor of Science |
Postgraduate Training
| 2021-2021 | Fellow, Physician Educators Certificate Program, McGovern Medical School UT Health, Houston, Texas |
| 2019-2021 | Postgraduate Fellow, Infectious Diseases, McGovern Medical School UT Health/MD Anderson Cancer Center, Houston, Texas |
| 2016-2018 | Residency, Internal Medicine, Ochsner Clinic Foundation |
| 2015-2016 | Internship, Internal Medicine, Ochsner Clinic Foundation |
Licenses & Certifications
| null | DEA Controlled Substance License |
| null | ABIM Internal Medicine Certification |
| null | ABIM Infectious Diseases Certification |
| null | Florida Board of Medicine |
| null | Texas Medical Board |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, 2021 - 2024
Associate Lecturer, Ochsner Clinical School, 2018 - 2021
Administrative Appointments/Responsibilities
Director, Antimicrobial Stewardship Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2025 - Present
Associate Chief Infection Control Officer, Department of Infectious Diseases, Infection Control & Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present
Extramural Institutional Committee Activities
Chair, Antimicrobial Stewardship Advisory Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Vice Chair, Infection Control Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Infectious Diseases Engagement & Wellness Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Chair, HLD & Sterilization Council, The University of Texas MD Anderson Cancer Center, 2025 - Present
Honors & Awards
| 2025 - Present | Fellow of the American College of Physicians, American College of Physicians |
| 2024 - Present | Castle Connolly Rising Star, Castle Connolly |
| 2023 - Present | Faculty Teacher of the Year Award, USF Health Division of Infectious Disease |
| 2020 - Present | IDWeek 2020 Trainee Award, Infectious Diseases Society of America |
| 2020 - Present | Chief Fellow, McGovern Medical School UT Health |
| 2018 - Present | Chief Medical Resident, Ochsner Clinic Foundation |
| 2017 - Present | Ochsner Clinical School Resident Teaching Award, Ochsner Clinical School |
| 2012 - Present | UAB Department of Medicine Summer Internship Program Award, University of Alabama School of Medicine |
| 2010 - Present | Beta Beta Beta Biology Honor Society |
| 2010 - Present | Mortar Board, Rhodes College, Torch Chapter |
| 2010 - Present | Omicron Delta Kappa, Rhodes College, Phi Circle |
| 2007 - Present | Eagle Scout, Boy Scouts of America |
| 2007 - Present | Morse Fellowship Award, Rhodes College |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Urinary Tract Infection and Asymptomatic Bacteriuria: Clinical Update and Pitfalls. Invited. Clinical and Research Lecture. Houston, Texas, US.
- 2024. USF ID Fellowship Bootcamp Series: Central Nervous System Infections. Invited. Tampa, Florida, US.
- 2024. USF Pulmonary Critical Care Medicine Core Curriculum: Mold Pneumonia in Oncology Patients. Invited. Tampa, Florida, US.
- 2024. USF Gynecology/Oncology Fellowship Didactic Series: Neutropenic Fever. Invited. Tampa, Florida, US.
- 2024. USF ID Fellowship Lecture Series: Pneumocystis. Invited. Tampa, Florida, US.
- 2024. UAB Lunch and Learn: HHV-6 and Allogeneic Bone Marrow Transplantation. Invited. Birmingham, Alabama, US.
- 2024. USF Gynecology/Oncology Fellowship Didactic Series: Sepsis. Invited. Tampa, Florida, US.
- 2024. USF ID Fellowship Lecture Series: HHV-6 and Allogeneic Bone Marrow Transplantation. Invited. Tampa, Florida, US.
- 2024. USF ID Fellowship Lecture Series: Mold Pneumonia in Oncology Patients. Invited. Tampa, Florida, US.
- 2023. OU Health (Oklahoma) Infectious Diseases Lecture Series: HHV-6 and Allogeneic Bone Marrow Transplantation. Invited. Oklahoma City, Oklahoma, US.
- 2023. USF ID Fellowship Bootcamp Series: Central Nervous System Infections. Invited. Tampa, Florida, US.
- 2023. USF ID Fellowship Board Review Series: Infections Immunocompromised Hosts. Invited. Tampa, Florida, US.
- 2023. Grand Rounds Lecture Series: EBV: Mononucleosis, HLH and Lymphoproliferative Disease. Invited. University of South Florida Department of Internal Medicine Grand Rounds. Tampa, Florida, US.
- 2023. USF ID Fellowship/USF Microbiology Department Joint Multidisciplinary Conference: Cytomegalovirus (CMV): Microbiology and Immune Modulation. Invited. Tampa, Florida, US.
- 2023. UTHSC (Tennessee) Pulmonary Critical Care Medicine Core Curriculum: Select Fungal Pneumonias in Oncology Patient. Invited. Memphis, Tennessee, US.
- 2023. USF Pulmonary Critical Care Medicine Core Curriculum: Pneumocystis Pneumonia. Invited. Tampa, Florida, US.
- 2023. USF ID Fellowship Lecture Series: LCMV and Prion Disease. Invited. Tampa, Florida, US.
- 2023. Transplant ID Journal Club: Effect of Prophylactic Letermovir on Late CMV-Related Mortality After Allogeneic Stem Cell Transplant. Invited. Tampa, Florida, US.
- 2022. USF ID Fellowship Bootcamp Series: ID Emergencies. Tampa, Florida, US.
- 2022. USF ID Fellowship Board Review Series: Central Nervous System Infections. Invited. Tampa, Florida, US.
- 2022. Transplant ID Journal Club: Effect of Prophylactic Foscarnet on HHV-6 Reactivation and Encephalitis. Invited. Tampa, Florida, US.
- 2022. USF ID Fellowship Lecture Series: EBV: Mononucleosis, HLH and Lymphoproliferative Disease. Invited. Tampa, Florida, US.
Regional Presentations
- 2024. HHV-6 and Allogeneic Bone Marrow Transplantation. Invited. New Orleans Citywide Infectious Disease Conference. New Orleans, Louisiana, US.
National Presentations
- 2025. Guidelines Update-HHV-6. Invited. Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. Honululu, Hawaii, US.
Selected Publications
Peer-Reviewed Articles
- Kampouri, E, Handley, GH, Phan, TL, Lee, YJ, Shaw, R, Carpenter, P, Dadwal, SS, Chemaly, RF, Papanicolaou, GA, Ogata, M, Boeckh, MJ, Zerr, DM, Hill, JA. American Society for Transplantation and Cellular Therapy Series #9. Transplantation and Cellular Therapy 31(8):480-493, 2025. e-Pub 2025. PMID: 40409689.
- Handley, GH, Yepes, A, Eliassen, E, Dominguez, G, Pasikhova, Y, Klinkova, O, Baluch, A, Febres-Aldana, A, Alsina, M, Elmariah, H, Khimani, F, Hansen, DK, Freeman, C, Jain, MD, Locke, FL, Lazaryan, A, Liu, HD, Mishra, A, Mirza, AS, Nishihori, T, Ochoa, L, Perez, LE, Pidala, J, Castaneda Puglianini, OA, Nieder, M, Perna, F, Kim, J, Bejanyan, N, Faramand, R. Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. Open Forum Infectious Diseases 11(10), 2024. e-Pub 2024. PMID: 39411216.
- Handley G, Yepes A, Eliassen E, Dominguez G, Pasikhova Y, Klinkova O, Baluch A, Febres-Aldana AJ, Alsina M, Elmariah H, Khimani F, Hansen DK, Freeman CL, Jain MD, Locke F, Lazaryan A, Liu HD, Mishra A, Mirza AS, Nishihori T, Ochoa L, Perez L, Pidala J, Puglianini OC, Nieder M, Perna F, Kim J, Bejanyan N, Faramand R. Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. Open Forum Infect Dis 11(10):ofae564, 2024. e-Pub 2024. PMID: 39411216.
- Pearson EM, Handley G, Greene J. Concurrent Zoster Sine Herpete and Hepatosplenic Fungal Infection in a Cancer Patient: A Case Report. Cureus 16(10):e72117, 2024. e-Pub 2024. PMID: 39574981.
- Khawaja F, Ahmed S, Iyer SP, Sassine J, Handley G, Prakash R, VanWierren T, Jackson J, Zubovskaia A, Ramdial J, Rondon G, Patel KK, Spallone A, Ariza-Heredia EJ, Mulanovich V, Angelidakis G, Jiang Y, Chemaly RF. Cytomegaloviral Infections in Recipients of Chimeric Antigen Receptor T-Cell Therapy: An Observational Study With Focus on Oncologic Outcomes. Open Forum Infect Dis 11(8):ofae422, 2024. e-Pub 2024. PMID: 39086466.
- Handley, GH, Greene, J, Cannella, AP, Velez, AP, Shah, S, Pasikhova, Y. Real-world Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients. Open Forum Infectious Diseases 11(5), 2024. e-Pub 2024. PMID: 38680607.
- Handley G, Greene J, Cannella AP, Velez AP, Shah S, Pasikhova Y. Real-world Experience of Posaconazole Therapeutic Drug Monitoring in Oncology Patients: Clinical Implications of Hypoalbuminemia as a Predictor of Subtherapeutic Posaconazole Levels. Open Forum Infect Dis 11(5):ofae185, 2024. e-Pub 2024. PMID: 38680607.
- Graeter A, Lee D, Handley G, Baluch A, Klinkova O. Chronic disseminated candidiasis in a patient with acute leukemia - an illustrative case and brief review for clinicians. BMC Infect Dis 24(1):296, 2024. e-Pub 2024. PMID: 38448809.
- Velez AP, Handley G, Morison A, Katzman JH, Kinkhova O, Quiltz R, Greene J, Pasikhova Y. Safety and Outcomes With Combination Therapy With Sarilumab and Baricitinib for Severe COVID-19 Respiratory Infection in Cancer Patients. Cancer Control 30:10732748231205864, 2023. e-Pub 2023. PMID: 37817417.
- Emanuel N, Siddique N, Greene J, Pasikhova Y, Morrison A, Ledbetter M, Handley G. Nocardia niwae Disseminated Nocardiosis: A Novel Species Presenting Concurrently With Lung Adenocarcinoma. Cureus 14(11):e31246, 2022. e-Pub 2022. PMID: 36505126.
- Baluch A, Handley G, Ludlow S, Morrison A, Velez A, Rojas MC, Pasikhova Y. Disseminated Toxoplasmosis in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report and Review of the Current Literature. Cureus 14(9):e29185, 2022. e-Pub 2022. PMID: 36259018.
- Handley G, Hand J. Adverse Effects of Immunosuppression: Infections. Handb Exp Pharmacol 272:287-314, 2022. e-Pub 2022. PMID: 34671868.
- Handley G, Khawaja F, Kondapi DS, Lee HJ, Kaufman GP, Neelapu SS, Fayad LE, Tummala S, Chi L, Strati P, Mulanovich VE. Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy. Int J Infect Dis 112:327-329, 2021. e-Pub 2021. PMID: 34600133.
- Handley G, Pankow S, Bard JD, Yee R, Nigo M, Hasbun R. Distinguishing cytomegalovirus meningoencephalitis from other viral central nervous system infections. J Clin Virol 142:104936, 2021. e-Pub 2021. PMID: 34352616.
- Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, King RW, Xu X, Gaggar A, Bailey WC, Dransfield MT, Blalock JE. A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 192(8):934-42, 2015. e-Pub 2015. PMID: 26151090.
- Wells JM, O'Reilly PJ, Szul T, Sullivan DI, Handley G, Garrett C, McNicholas CM, Roda MA, Miller BE, Tal-Singer R, Gaggar A, Rennard SI, Jackson PL, Blalock JE. An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 190(1):51-61, 2014. e-Pub 2014. PMID: 24874071.
Review Articles
- Makovich Z, Radosavljevic I, Chapyala S, Handley G, Pena L, Mok S, Friedman M. Rationale for Hepatitis C Virus Treatment During Hematopoietic Stem Cell Transplant in the Era of Novel Direct-Acting Antivirals. Dig Dis Sci 69(9):3488-3500, 2024. e-Pub 2024. PMID: 38990268.
- Kampouri E, Handley G, Hill JA. Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape. Viruses 16(4), 2024. e-Pub 2024. PMID: 38675841.
- Lemay, D, Handley, GH, Baluch, A, Greene, JN. Adenovirus Enterocolitis in Hematopoietic Stem Cell Transplant Patients. Infectious Diseases in Clinical Practice 31(1), 2023. e-Pub 2023.
- Handley G. Current Role of Prospective Monitoring and Preemptive and Prophylactic Therapy for Human Herpesvirus 6 After Allogeneic Stem Cell Transplantation. Open Forum Infect Dis 9(8):ofac398, 2022. e-Pub 2022. PMID: 36004309.
- Handley G, Hasbun R, Okhuysen P. Human herpesvirus 6 and central nervous system disease in oncology patients: A retrospective case series and literature review. J Clin Virol 136:104740, 2021. e-Pub 2021. PMID: 33548682.
Abstracts
- Feldman A, Cantu S, Poths R, Powell J, Handley G, Spallone A. Setting the Standard: Developing a High-Consequence Infectious Disease Preparedness Policy for a Comprehensive Cancer Hospital. SHEA Spring Conference.
Book Chapters
- Eatrides, J, Handley, GH. Microorganism-Induced Benign Hematologic Conditions. In: Non-Neoplastic Hematologic Disorders. 1. Springer Cham, 715-734, 2024.
- Handley, GH. Human Herpesvirus 6A, 6B, 7, and 8 in Hematopoietic Stem Cell Transplant: A Clinical Review. In: Global Virology IV: Viral Disease Diagnosis and Treatment Delivery in the 21st Century. 1. Springer Cham, 189-200, 2024.
- Handley, GH. Epstein-Barr Virus: Acute Infection, Oncogenesis, Prevention and Pitfalls. In: Global Virology IV: Viral Disease Diagnosis and Treatment Delivery in the 21st Century. 1. Springer Cham, 167-188, 2024.
- Handley, GH, Ostrosky-Zeichner, L. Antifungal Therapy in the Surgical Patient. In: Current Surgical Therapy. 14. Elsevier, 1491-1500, 2023.
- Handley, GH, Hand, J. Adverse Effects of Immunosuppression. In: Pharmacology of Immunosuppression. 1. Springer Nature Switzerland AG, 287-314, 2022.
- Handley G. Adjunct Corticosteroid Therapy for Patients with Community Acquired Pneumonia. In: Clinical Approaches to Hospital Medicine. 1. Springer International Publishing AG, 45-54, 2018.
Letters to the Editor
- Handley G, Pasikhova Y, Hill JA. Letter to the Editor Regarding "Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation". Transplant Cell Ther 29: 645-646, 2023.
Patient Reviews
CV information above last modified October 23, 2025