Heather G. Lyu, M.D., MBI
Department of Surgical Oncology, Division of Surgery
About Dr. Heather G. Lyu
Heather Lyu, M.D., M.B.I. is an Assistant Professor in the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center and Director of the Department of Surgical Oncology Clinical Research Informatics Program. Her clinical practice focuses on the multidisciplinary care of patients with soft-tissue sarcomas. She received her medical degree from Johns Hopkins University School of Medicine and completed her surgical training at Brigham and Women's Hospital in Boston, MA, followed by a fellowship in Complex General Surgical Oncology at MD Anderson Cancer Center. She also completed training in Clinical Informatics at Brigham and Women's Hospital and obtained her Master of Biomedical Informatics degree from Harvard Medical School.
Dr. Lyu's research sits at the intersection of surgical oncology and clinical informatics, with a focus on building next-generation data infrastructure to support high-quality cancer research. She led the development of an integrated, prospective data system that unifies structured clinical documentation with advanced analytics platforms, enabling the capture of rich, longitudinal patient data at scale. A central component of her work is harnessing artificial intelligence — including large language models — to extract nuanced clinical variables from clinical documentation that are otherwise inaccessible through traditional data collection methods. These efforts span tumor characteristics, treatment details, and long-term oncologic outcomes such as recurrence. By combining purpose-built data architecture with AI-driven data capture, Dr. Lyu's program aims to accelerate surgical oncology research, improve the precision of outcome prediction, and ultimately advance the care of patients with complex malignancies.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
I plan to conduct innovative research in informatics relevant to surgical oncology and the field of sarcoma. First of all, I will develop a research informatics program to standardize data abstraction and collection. I have already started working on this program by creating data standards for a melanoma specific synoptic operative report as well as for new patients seen in the pancreas clinic. This initiative was partially funded with an institutional research award last year (Jesse H. Jones Fellowship in Cancer Education Research Award). I plan to create similar EHR-based data standardization and automated data extraction processes for all disease sites within the department. I will also continue to work with the institutional Context Engine to assist with the ingression of all surgical data and combine them with those collected by other disciplines, including pathology and imaging data. My ultimate goal is to study the implementation of this data infrastructure and study the best practices for this process. Secondly, for data elements and clinical variables that we are unable to structure or extract from the EHR, I plan to implement natural language processing (NLP) algorithms to derive data elements from unstructured documentation and existing clinical data points. NLP is currently underutilized to identify important oncologic endpoints from the EHR. I intend to start by studying the use of NLP for early prediction of recurrence in patients who undergo surgery for soft tissue sarcoma. I hope to obtain extramural funding to support this work, particularly through opportunities promoted by the National Cancer Institute’s Center for Biomedical Informatics and Information Technology. Finally, I will study the role of the real world or EHR-based evidence in developing predictive models to identify sarcoma patients who would benefit from surgical vs nonsurgical interventions on presentation. Specifically, I hope to perform a study on identifying real world data for a prediction model to identify patients with small GISTs who would benefit from early surgical intervention.
Clinical Interests
My clinical focus will be in sarcoma. I will be working with a multidisciplinary team including medical oncologists, radiation oncologists, pathologists, and radiologists to provide the most up to date, comprehensive care for patients with these rare tumors. In my practice, I will be expected to completely understand the biology and behavior of all types of sarcomas and apply this knowledge to taking care of patients. Additionally, I will also need to gain expertise in a wide range of surgical techniques and approaches, including but not limited to minimally invasive procedures, limb-sparing surgery, and reconstructive procedures. I will develop my clinical skill under the guidance of my senior partners in the sarcoma section, particularly my mentor, Christina Roland.
Education & Training
Degree-Granting Education
| 2019 | Harvard Medical School, Boston, Massachusetts, US, MBI in Biomedical Informatics |
| 2014 | Johns Hopkins University, School of Medicine, Baltimore, Maryland, US, MD |
| 2009 | University of Virginia, Charlottesville, Virginia, US, BA in Media Studies |
Postgraduate Training
| 2021-2023 | Clinical Fellowship, Complex and General Surgical Oncology, University of Texas, Houston, Texas |
| 2017-2019 | Research Fellowship, Clinical Informatics and Innovations, Partners Healthcare, Boston, Massachusetts |
| 2014-2021 | Clinical Residency, General Surgery, Brigham and Women's Hospital, Boston, Massachusetts |
Licenses & Certifications
| 2024 | American Board of Surgery - Complex General Surgical Oncology |
| 2022 | Clinical Informatics |
| 2022 | American Board of Surgery - General Surgery |
| 2021 | Texas Medical Board |
| 2017 | Massachusetts Medical Board |
Experience & Service
Administrative Appointments/Responsibilities
Vice Chair, ECMS Medical AI Advisory Committee, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2026 - Present
Director, Clinical Research Informatics Program, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2024 - Present
Internal Advisory Council Member, Institute for Date Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2024 - Present
Extramural Institutional Committee Activities
Member, Publications Committe, The University of Texas MD Anderson Cancer Center, 2026 - Present
Chair, Surgical and Procedural Informatics Working Group, American Medical Informatics Association, 2024 - Present
Member, Program Evaluation Committee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Clinical Operations Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Cancer Surgery Standards Program, American College of Surgeons Cancer Programs, 2023 - Present
Member, Sarcoma Disease Site Working Group, Society for Surgical Oncology, 2023 - 2025
Member, Core for Quality Improvement Methodology and Implementation (CQMI), American College of Surgeons Cancer Programs, 2022 - Present
Fellow Safety and Quality Officer, Complex General Surgical Oncology, The University of Texas MD Anderson Cancer Center, 2022 - 2023
Member, Complex General Surgical Oncology Fellowship Admissions Committee, The University of Texas MD Anderson Cancer Center, 2022 - 2023
Member, Brigham and Women’s Hospital Surgical Residency Program Evaluation Committee, The University of Texas MD Anderson Cancer Center, 2016 - 2021
Member, Partners Graduate Medical Education Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2021
Editorial Activities
Associate Editor, npi Digital Surgery, 2025 - Present
Associate Editor, npi Digital Medicine, 2023 - 2025
Honors & Awards
| 2026 | Charles M. Balch, MD Endowed International Fellowship in Surgical Oncology |
| 2024 | The Gerald B. Healy Traveling Mentorship Fellowship award, The American College of Surgeons |
| 2023 | The 15th International Gastric Cancer Congress Travel Grant |
| 2022 | Jesse H. Jones Fellowship in Cancer Education Research Award |
| 2021 | Francis Daniels Moore Award, Chief Resident |
| 2021 | Society of Asian Academic Surgeons Resident Development Scholarship |
| 2020 | Surgery Class of ’63 Scholar, Research Resident |
| 2019 | Harvard Graduate School of Education Innovation and Ventures in Education Pitch Competition 2nd Prize Winner |
| 2018 | Association of Women Surgeons (AWS) Starr Poster Contest Winner, Association of Women Surgeons |
| 2017 | Rudolph Vollman Award, Junior Resident |
| 2016 | New England Surgical Society Poster of Distinction Award |
| 2011 | Medical Student Research Day Winner, Johns Hopkins University |
| 2011 | EASL Young Investigators Award |
| 2007 | UVA Center for Global Health Scholarship Winner |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2026. AI and Data Science in Oncology. Invited. NASOG Alumni Symposium. Houston, Texas, US.
- 2025. Leveraging Big Data into Clinical Studies & QI:. Invited. MD Anderson Cancer Center Clinical Trials Course. Houston, Texas, US.
- 2025. HCA Grand Rounds. Invited. Houston, Texas, US.
- 2024. Leveraging Big Data into Clinical Studies & QI:. Invited. MD Anderson Cancer Center Clinical Trials Course, US.
- 2023. Leveraging Big Data into Clinical Studies & QI:. Invited. MD Anderson Cancer Center Clinical Trials Course, US.
- 2023. Better Data, Better Outcomes: How to Realize the Value of Big Data in Surgical Oncology. Invited. Grand Rounds, US.
- 2021. Surgical Informatics: Defining the Role of Clinical Informatics in Academic Surgery. Invited. Surgery Grand Rounds, US.
- 2019. The Role of Clinical Informatics in Surgery. Invited. Surgery Grand Rounds, US.
- 2019. The Role of Informatics in Academic Surgery. Invited. Surgery Grand Rounds, US.
National Presentations
- 2026. Leveraging Large Language Models to Extract Sarcoma-Specific Data and Outcomes from Clinical Notes. Conference, US.
- 2026. Artificial Intelligence and Digital Innovation in Surgery. Invited. MESH Core Healthcare Innovation Bootcamp. Boston, Massachusetts, US.
- 2026. Surgery: The Primary Treatment for GIST. Invited. GIST Summit. Houston, Texas, US.
- 2026. ERAS in Retroperitoneal Sarcoma. Invited. Phoenix, Arizona, US.
- 2026. Building on Solid Ground: Data Infrastructure as the Foundation for AI Innovation in Surgical Oncology. Invited, US.
- 2026. Emerging Roles for AI in Oncology. Invited, US.
- 2025. Leveraging Large Language Models to Extract Cancer-Specific Data Elements and Recurrence Outcomes from Clinical Notes of Patients with Primary Soft Tissue Sarcoma. Poster, US.
- 2025. AI in Surgery: Advancing Surgical Research and Patient Care through Innovation. Invited, US.
- 2025. Data to Bedside: How to Leverage Artificial Intelligence and Informatics in Clinical Practice. Invited, US.
- 2025. The Role of Artificial Intelligence (AI) in Surgical Education. Invited. Rancho Mirage, CA.
- 2025. Identifying the Path to Soft Tissue Sarcoma: The Validation of Multimorbidity Disease Trajectories. Poster, US.
- 2025. Evaluating Synthetic Data Quality: Gaussian and CT-GAN Models in Replicating Clinical Outcomes in Pancreas Cancer Research. Poster, US.
- 2025. The Role of Synoptic Operative Reporting in Accurate and Efficient Data Capture for Patients Undergoing Pancreatectomy. Poster, US.
- 2025. Mapping Multimorbidity Trajectories for Pancreas Cancer from Real World Data. Poster, US.
- 2025. The Impact of Vascular Management on Complications in Patients with Retroperitoneal Leiomyosarcoma. Conference, US.
- 2024. Enhancing Operative Documentation of Cancer Operations: The Transition to Synoptic Operative Reporting at a Cancer Center. Poster, US.
- 2024. Gerald B. Healy Traveling Mentorship Fellowship Award. Invited, US.
- 2024. Should you Consult the Plastic Surgeon? Machine Learning-Powered Nomograms to Predict Minor and Major Surgical Site Occurrences in Thigh Soft Tissue Sarcoma Reconstructions. Conference, US.
- 2024. Should you Consult the Plastic Surgeon? Machine Learning-Powered Nomograms to Predict Minor and Major Surgical Site Occurrences in Thigh Soft Tissue Sarcoma Reconstructions. Conference. Scientific Abstract Presentations: Reconstructive Session 8. San Diegp, CA, US.
- 2024. When To Skip The Ladder And Take The Elevator: Complex Reconstructions Predict Reduced Complication Rates Compared To Simpler Techniques After Resection Of Soft Tissue Sarcomas Located In The Thigh. Poster, US.
- 2024. Reconstructing Soft Tissue Sarcoma Patients: Tumor Bed Excision Defects Are Deceiving And Result In Higher Reoperation Rates. Poster. 102nd American Association of Plastic Surgeons, US.
- 2024. Beyond Theory - Practical Marketing and Operational Implementation in Surgical Informatics. Invited, US.
- 2024. Evaluation of the MasSpec Pen Technology for Molecular Identification of Sarcomas and Surgical Margin Assessment. Conference, US.
- 2023. The Development and Evaluation of a Synoptic Operative Report for Patients Undergoing Surgery for Soft Tissue Sarcoma. Conference, US.
- 2023. Health-Related Quality of Life in Patients with Resectable Retroperitoneal Dedifferentiated Liposarcoma (DDLPS) Treated with Neoadjuvant Checkpoint Blockade in a Randomized Phase II Clinical Trial. Poster, US.
- 2023. Effect of Surgical Approach on Early Return to Intended Oncologic Therapy After Resection for Pancreatic Ductal Adenocarcinoma. Poster. Society of Surgical Oncology. Boston, MA, US.
- 2023. Social vulnerability is associated with worse survival among patients with extremity and truncal soft-tissue sarcoma. Poster, US.
- 2023. Analysis of Hospital Costs for Robotic and Open Pancreatectomy at a Cancer Center. Poster, US.
- 2023. Data Science in Academic Surgery: Leveraging Real World Data and Capitalizing on Opportunities in Artificial Intelligence. Invited, US.
- 2022. Patterns of Care and Outcomes of Patients Presenting with Small Gastrointestinal Stromal Tumors at a High-Volume Sarcoma Center. Conference, US.
- 2022. Development of an electronic health record registry to facilitate collection of Commission on Cancer (CoC) metrics for patients undergoing surgery for breast cancer. Poster, US.
- 2022. Health-Related Quality of Life in patients with resectable undifferentiated pleomorphic sarcoma treated with neoadjuvant checkpoint blockade in a single institution randomized phase II clinical trial. Poster, US.
- 2020. Gender Disparities in Presentations at the Society of Surgical Oncology (SSO) Meeting from 2014-2019. Conference, US.
- 2020. Increased BMI is protective against hypocalcemia in patients undergoing total thyroidectomy for thyroid cancer. Poster, US.
- 2019. Mind The Gap: Female Residents are Underrepresented as Award Recipients in General Surgery Programs. Poster, US.
- 2019. Implementation and Evaluation of an Electronic Small Bowel Obstruction Treatment Pathway. Poster, US.
- 2018. Design and Development of an Electronic Small Bowel Obstruction Treatment Pathway. Poster, US.
- 2018. Second Shift at Home: Impact of Domestic Responsibilities on Career Satisfaction for Physician Mothers in Procedural Fields. Conference, US.
- 2018. Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Surgery for Soft Tissue Sarcoma (STS): Early Results of a Prospective Quality Improvement Protocol. Conference, CA.
- 2018. Domestic Responsibilities of Physician Mothers Across Specialties. Conference, US.
- 2018. When Not Winning Means Losing: Underrepresentation of Women Surgeons in Recognition Awards at a Single Institution. Poster, US.
- 2018. When Not Winning Means Losing: Underrepresentation of Women Surgeons in Recognition Awards at a Single Institution. Poster. Association of Women Surgeons Resident and Medical Student Research Forum, US.
- 2017. Underestimation of the Burden of Sarcoma within a Single Institution. Conference, US.
- 2017. Implementation of a RFID Tracking System to Capture Trauma Attending Arrival Times in the Emergency Department. Poster, US.
- 2017. Global Disparities in Preoperative Staging of Colorectal Cancer. Poster, US.
- 2017. Global Disparities in Operative Management and Lymph Nodes Harvest of Colorectal Cancer. Poster, US.
- 2016. Unplanned Reoperation After Hepatectomy: An Analysis of Risk Factors. Poster, US.
- 2016. Unplanned Reoperation After Pancreatic Resection: An Analysis of Risk Factors. Poster, US.
- 2016. Predictors of Unplanned 30-Day Reoperation after Pancreatic Resection. Conference, US.
- 2013. Unnecessary Surgery: Characteristics of Patients and Providers. Poster, US.
- 2012. Spleen Preserving Laparoscopic Distal Pancreatectomy. Poster, US.
- 2012. Laparoscopic Whipple: Feasibility and Outcomes. Poster, US.
- 2012. Spleen Preserving Laparoscopic Distal Pancreatectomy. Poster, US.
- 2012. Laparoscopic Whipple: Feasibility and Outcomes. Poster, US.
- 2012. Patient Satisfaction as an Indicator of Quality Surgical Care?. Conference, US.
International Presentations
- 2026. THE VALIDATION OF LARGE LANGUAGE MODEL-BASED PREOPERATIVE RISK STRATIFICATION FOR SARCOMA RECURRENCE. Poster. Connective Tissue Oncology Society (CTOS) 2026 Annual Meeting.
- 2026. Immune checkpoint blockade (ICB) in advanced/metastatic leiomyosarcoma (LMS): Real-world cohort from MD Anderson. Poster. Connective Tissue Oncology Society (CTOS) 2026 Annual Meeting.
- 2026. Association of PTEN/PI3K and cell-cycle signaling with distinct tumor immune microenvironment (TIME) niches in leiomyosarcoma (LMS). Invited. Connective Tissue Oncology Society (CTOS) 2026 Annual Meeting.
- 2026. IVC Leiomyosarcomas: Histology, Epigenetics, and Prognostic Factors. Invited. 4th Hispano-Luso Meeting on Updates in Sarcoma Treatment.
- 2026. Being an Effective Educator as a Junior Faculty Member. Invited. Houston, US.
- 2026. How to Deliver an Effective Presentation. Invited, US.
- 2026. The Role of Artificial Intelligence in Surgical Education. Invited, US.
- 2023. Analysis of Hospital Costs for Robotic and Open Gastrectomy at a Cancer Center. Conference, JP.
- 2019. Nephrectomy Outcomes Following En Bloc Resection Of Primary Retroperitoneal Sarcoma: A Multicenter Analysis. Poster, JP.
- 2018. Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Surgery for Soft Tissue Sarcoma (STS): Early Results of a Prospective Quality Improvement Protocol. Conference, IT.
- 2011. Genomic Changes in Genotype C2 Hepatitis B Virus Closely Associated with the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B: A Cohort Study. Poster, DE.
- 2011. The Synergistic Effect of A1896, T1653, and T1762/A1764 Mutations in the Basal Core Promoter Region of Genotype C2 HBV on the Occurrence of Hepatocellular Carcinoma. Poster, DE.
Formal Peers
- 2026. Building on Solid Ground: Data Infrastructure as the Foundation for AI Innovation in Surgical Oncology. Houston, Texas, US.
- 2023. Better Data, Better Outcomes: How to Realize the Value of Big Data in Surgical Oncology. Invited. Houston, TX, US.
- 2021. Surgical Informatics: Defining the Role of Clinical Informatics in Academic Surgery. Invited. Boston, MA, US.
- 2019. The Role of Clinical Informatics in Surgery. Invited. Boston, MA, US.
- 2019. The Role of Informatics in Academic Surgery. Invited. Boston, MA, US.
Grant & Contract Support
| Date: | 2017 - 2019 |
| Title: | T15LM007092-National Library of Medicine Institutional training grant for research training in biomedical informatics and data science (T15) |
| Funding Source: | National Library of Medicine |
| Role: | Trainee |
Selected Publications
Peer-Reviewed Articles
- Lominchar PL, Diaz-Cambronero O, Munoz-Munoz P, Fernandez-Candela A, Hernandez-Sanchez P, Javaloyes N, Olivares V, Rodrigues CC, Prieto I, Diaz-Gomez D, Ibanez CB, Medeiros P, Marrero-Marrero P, Lopez M, Vallejo I, Sanz MC, Videira F, Martins P, Orbis P, Rubio A, Valderrama SO, Bermudez F, Alvarez R, Roland CL, Lyu H, Clarke CN, Munoz-Casares C, Asencio JM, Vasques H. ASO Visual Abstract: Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery. Ann Surg Oncol, 2026. e-Pub 2026. PMID: 42081025.
- Okui J, Prakash LR, Lyu HG, Morgan RB, Li JJ, Blum-Murphy MA, Ajani JA, Hofstetter WL, Rice DC, Mansfield PF, Swisher SG, Badgwell BD, Ikoma N. Immunotherapy Response in Microsatellite Instability-High Gastroesophageal Adenocarcinoma. JAMA Surg, 2026. e-Pub 2026. PMID: 41984470.
- Lominchar PL, Diaz-Cambronero O, Munoz-Munoz P, Fernandez-Candela A, Hernandez-Sanchez P, Javaloyes N, Olivares V, Rodrigues CC, Prieto Nieto I, Diaz-Gomez D, Ibanez CB, Pinto P, Marrero-Marrero P, Lopez M, Vallejo I, Sanz MC, Videira F, Martins P, Orbis P, Rubio A, Valderrama SO, Bermudez F, Alvarez R, Roland CL, Lyu H, Clarke CN, Munoz-Casares C, Asencio JM, Vasques H. Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery. Ann Surg Oncol, 2026. e-Pub 2026. PMID: 41973294.
- Malik N, Traweek R, Lyu HG, Witt R, Chiang YJ, Cass S, Cope B, Mericli A, Lillemoe HA, Scally C, Torres K, Hunt K, Roland CL, Keung EZ. ASO Visual Abstract: Timing and Frequency of Surveillance After Resection of Extremity and Trunk Soft Tissue Sarcoma-Identifying Opportunities for Improvement. Ann Surg Oncol, 2026. e-Pub 2026. PMID: 41913009.
- Malik N, Traweek R, Lyu HG, Witt R, Chiang YJ, Cass S, Cope B, Mericli A, Lillemoe HA, Scally C, Torres K, Hunt K, Roland CL, Keung EZ. Timing and Frequency of Surveillance After Resection of Extremity and Trunk Soft Tissue Sarcoma: Identifying Opportunities for Improvement. Ann Surg Oncol, 2026. e-Pub 2026. PMID: 41807838.
- Yoder, A, Netherton, T, Wang, X, Lim, TY, Wang, C, Luo, D, Wang, C, Thrower, SL, Nguyen, C, Lyu, H, Scally, CP, Roland, CL, Mitra, D, Bishop, AJ, Farooqi, AS, Guadagnolo, BA. The Impact of Radiation Dose to Bowel on the Risk of Developing Gastrointestinal Toxicities When Treating Abdominopelvic Soft-Tissue Sarcomas With Preoperative Radiation Therapy. Advances in Radiation Oncology 11(2), 2026. e-Pub 2026. PMID: 41492444.
- Malik, N, Kim, S, Scally, CP, Keung, EZ, Lillemoe, HA, Torres, KE, Hunt, KK, Khan, S, Roland, CL, Lyu, H. The Impact of Vascular Management on Postoperative Complications in Patients Undergoing Surgery for Retroperitoneal Leiomyosarcoma. Current Oncology 33(2), 2026. e-Pub 2026. PMID: 41744854.
- Takayama, M, Snyder, RA, Lyu, H, Mensah, CB, Prakash, L, Landry, JP, Tsai, EH, Siddiqui, ZA, Maxwell, JE, Kim, M, Tzeng, CD, Lee, JE, Katz, MH, Ikoma, N. ASO Visual Abstract. Annals of surgical oncology 32(13):10056, 2025. e-Pub 2025. PMID: 41085798.
- Takayama, M, Snyder, RA, Lyu, H, Mensah, CB, Prakash, L, Landry, JP, Tsai, EH, Siddiqui, ZA, Maxwell, JE, Kim, M, Tzeng, CD, Lee, JE, Katz, MH, Ikoma, N. Association Between Intraoperative Hypothermia and Postoperative Pancreatic Fistula. Annals of surgical oncology 32(13):9979-9987, 2025. e-Pub 2025. PMID: 40935892.
- Lewis, KA, Lyu, H, Yammanur, M, Larsson, L, Willis, JA, Smaglo, BG, Katz, MH, Snyder, RA. Real-time implementation and validation of a natural language processing tool to improve clinical trial enrollment in pancreatic cancer. JCO Oncology Practice 21:127, 2025. e-Pub 2025.
- Wang, L, Li, R, Wen, A, Lu, Q, Wang, J, Ruan, X, Gamboa, AC, Malik, N, Roland, CL, Katz, MH, Lyu, H, Liu, H. Discovering signature disease trajectories in pancreatic cancer and soft-tissue sarcoma from longitudinal patient records. Journal of Biomedical Informatics 171, 2025. e-Pub 2025. PMID: 41120049.
- Lyu, H, Hirata, Y, Lu, P, Maxwell, JE, Snyder, RA, Kim, M, Tran Cao, HS, Tzeng, CD, Katz, MH, Ikoma, N. Analysis of hospital costs for robotic and open pancreatectomy incurred during the implementation of a robotic pancreatectomy program at a cancer center. Annals of Gastroenterological Surgery 9(5):1066-1074, 2025. e-Pub 2025. PMID: 40922924.
- Elmorsi, R, Camacho, L, Krijgh, DD, Lyu, H, Roubaud, MS, Torres, KE, Lewis, VO, Roland, CL, Mericli, AF. Extremity Soft Tissue Sarcoma Reconstruction Nomograms. JCO Clinical Cancer Informatics 9, 2025. e-Pub 2025. PMID: 40499089.
- Elmorsi, R, Camacho, L, Krijgh, DD, Lyu, H, Roubaud, MS, Torres, KE, Lewis, VO, Roland, CL, Mericli, AF. Extremity Soft Tissue Sarcoma Reconstruction Nomograms. JCO Clinical Cancer Informatics 9, 2025. e-Pub 2025. PMID: 40499089.
- Wang, L, Wen, A, Fu, S, Ruan, X, Huang, M, Li, R, Lu, Q, Lyu, H, Williams, AE, Liu, H. A scoping review of OMOP CDM adoption for cancer research using real world data. NPJ Digital Medicine 8(1), 2025. e-Pub 2025. PMID: 40189628.
- Malik, N, Krause, KJ, Keung, EZ, Lyu, H, Lillemoe, HA, Scally, CP, Torres, KE, Hunt, KK, Austin, M, Roland, CL. Optimal surveillance for detecting sarcoma lung metastasis – A systematic review. Surgical Oncology Insight 2(1), 2025. e-Pub 2025. PMID: 40191537.
- Wang L, Li R, Wen A, Lu Q, Wang J, Ruan X, Gamboa A, Malik N, Roland CL, Katz MHG, Lyu H, Liu H. Discovering Signature Disease Trajectories in Pancreatic Cancer and Soft-tissue Sarcoma from Longitudinal Patient Records. medRxiv, 2025. e-Pub 2025. PMID: 40034771.
- Tomczak, K, Patel, MS, Bhalla, A, Peterson, CB, Landers, S, Callahan, SC, Zhang, D, Wong, J, Landry, JP, Lazar, A, Livingston, JA, Guadagnolo, BA, Lyu, H, Lillemoe, HA, Roland, CL, Keung, EZ, Scally, CP, Hunt, KK, McCutcheon, IE, Slopis, JM, Gu, J, Scheet, PA, Wang, L, Rai, K, Torres, KE. Plasma DNA Methylation-Based Biomarkers for MPNST Detection in Patients With Neurofibromatosis Type 1. Molecular Carcinogenesis 64(1):44-56, 2025. e-Pub 2025. PMID: 39600120.
- Lyu, H, Roland, CL, Scally, CP. ASO Author Reflections. Annals of surgical oncology 31(13):9285-9286, 2024. e-Pub 2024. PMID: 39320401.
- Lyu HG, Witt RG, Rajkot N, Keung EZ, Torres KE, Hunt KK, Somaiah N, Lazar AJ, Roland CL, Scally CP. Patterns of Care and Outcomes of Patients with Small Gastrointestinal Stromal Tumors at a High-Volume Sarcoma Center. Ann Surg Oncol 31(13):9258-9264, 2024. e-Pub 2024. PMID: 39230849.
- Lu PW, Lyu HG, Prakash LR, Chiang YS, Maxwell JE, Snyder RA, Kim MP, Tzeng CD, Katz MHG, Ikoma N. Effect of surgical approach on early return to intended oncologic therapy after resection for pancreatic ductal adenocarcinoma. Surg Endosc 38(9):4986-4995, 2024. e-Pub 2024. PMID: 38987482.
- Elmorsi R, Camacho L, Krijgh DD, Tilney GS, Lyu H, Traweek RS, Witt RG,, Roubaud MS, Roland CL, Mericli AF. Optimizing Morbidity in Unplanned Soft Tissue Sarcoma Excisions. Ann Plast Surg 93(3):361-368, 2024. e-Pub 2024. PMID: 38920187.
- Elmorsi R, Camacho L, Krijgh DD, Tilney GS, Lyu H, Traweek RS, Witt RG, Roubaud MS, Roland CL, Mericli AF. ASO Visual Abstract: Sarcoma Size and Limb Dimensions Predict Complications, Recurrence, and Death in Patients with Soft Tissue Sarcoma in the Thigh-A Multidimensional Analysis. Ann Surg Oncol 31(8):5447-5448, 2024. e-Pub 2024. PMID: 38719992.
- Elmorsi R, Camacho L, Krijgh DD, Tilney GS, Lyu H, Traweek RS, Witt RG, Roubaud MS, Roland CL, Mericli AF. Sarcoma Size and Limb Dimensions Predict Complications, Recurrence, and Death in Patients with Soft Tissue Sarcoma in the Thigh: A Multidimensional Analysis. Ann Surg Oncol, 2024. e-Pub 2024. PMID: 38520583.
- Hirata Y, To C, Lyu H, Smith GL, Samuel JP, Tran Cao HS, Badgwell BD, Katz MHG, Ikoma N. Prevalence of and Factors Associated with Financial Toxicity After Pancreatectomy and Gastrectomy. Ann Surg Oncol, 2024. e-Pub 2024. PMID: 38536586.
- Traweek RS, Lyu HG, Witt RG, Snyder RA, Nassif EF, Krijgh DD, Smith JM, Tilney GS, Feng C, Chiang YJ, Torres KE, Roubaud MJ, Scally CP, Hunt KK, Keung EZ, Mericli AF, Roland CL. High Community-Level Social Vulnerability is Associated with Worse Recurrence-Free Survival (RFS) After Resection of Extremity and Truncal Soft Tissue Sarcoma. Ann Surg Oncol 31(6):4138-4147, 2024. e-Pub 2024. PMID: 38396039.
- Lyu HG, Snyder RA, Roland CL. ASO Author Reflections: Is a Patient's Home Address Associated with Survival Outcomes After Surgery for Extremity and Truncal Soft Tissue Sarcoma?. Ann Surg Oncol 31(6):4148-4149, 2024. e-Pub 2024. PMID: 38504045.
- Hirata Y, Lyu H, Smith GL, Wang XS, Tran Cao HS, Katz MHG, Ikoma N. What Defines the Value of Minimally Invasive Surgery for Cancer Patients? Ann Surg Oncol. Ann Surg Oncol 31(4):2204-2207, 2024. e-Pub 2024. PMID: 38123730.
- Hirata Y, Lyu HG, Azimuddin AM, Lu P, Ajith J, Schmeisser JA, Ninan EP, Lee KH, Badgwell BD, Mansfield P, Ikoma N. Cost Analysis for Robotic and Open Gastrectomy. Ann Surg Open 5(1):e396, 2024. e-Pub 2024. PMID: 38883961.
- Krijgh DD, Smith JM, Tilney G, Lyu H, Traweek RS, Witt RG, Roubaud MJ, Correa AM, Roland CL, Mericli AF. Identifying risk factors and analyzing reconstructive outcomes in patients with lower-extremity soft-tissue sarcoma. J Plast Reconstr Aesthet Surg 89:174-185, 2024. e-Pub 2024. PMID: 38199219.
- Mericli AF, Elmorsi R, Camacho L, Hassan A, Krijgh DD, Tilney G, Lyu H, Traweek RS, Witt RG, Roubaud MS, Roland CL. When to ditch the ladder and take the elevator: The Anderson SArcoma Risk of Complications (A-SARC) score to guide reconstructive decision-making in extremity soft tissue sarcoma patients. J Surg Oncol, 2024. e-Pub 2024. PMID: 38623064.
- Traweek RS, Lyu H, Witt RG, Snyder RA, Nassif EF, Krijgh DD, Smith JM, Tilney GS, Feng C, Chiang YJ, Torres KE, Roubaud MJ, Scally CP, Hunt KK, Keung EZ, Mericli AF, Roland CL. ASO Visual Abstract: High Community-Level Social Vulnerability is Associated with Worse Recurrence-Free Survival Following Resection of Extremity and Truncal Soft-Tissue Sarcoma. Ann Surg Oncol, 2024. e-Pub 2024. PMID: 38546800.
- Lyu HG, Lu P, Mahvi DA, Kuo LEY, Wong SL, Raut CP, Cho NL. Gender Disparities in Presentations at the Society of Surgical Oncology (SSO) Meetings From 2014 to 2019. Ann Surg Oncol 29(13):8107-8114, 2022. e-Pub 2022. PMID: 35821294.
- Mahvi DA, Witt RG, Lyu HG, Gawande AA, Nehs MA, Doherty GM, Cho NL. Increased Body Mass Index is Associated With Lower Risk of Hypocalcemia in Total Thyroidectomy Patients. J Surg Res 279:240-246, 2022. e-Pub 2022. PMID: 35797751.
- Lyu HG, Kantor O, Laws AD, McDonald J, Pham L, Dominici LS, Vincuilla J, Raut CP, Danilchuk B, Novak L, Parker T, King TA, Mittendorf EA. Development of an Electronic Health Record Registry to Facilitate Collection of Commission on Cancer Metrics for Patients Undergoing Surgery for Breast Cancer. JCO Clin Cancer Inform 6:e2200012, 2022. e-Pub 2022. PMID: 36215674.
- Gordon WJ, Ikoma N, Lyu H, Jackson GP, Landman A. Protecting procedural care-cybersecurity considerations for robotic surgery. NPJ Digit Med 5(1):148, 2022. e-Pub 2022. PMID: 36127420.
- Fairweather M, Lyu H, Conti L, Callegaro D, Radaelli S, Fiore M, Ng D, Swallow C, Gronchi A, Raut CP. Postnephrectomy outcomes following en bloc resection of primary retroperitoneal sarcoma: multicentre study. Br J Surg 109(2):165-168, 2022. e-Pub 2022. PMID: 34718436.
- Lyu HG, Smink DS, Doherty GM, Melnitchouk N, Cho NL. When not winning means losing: Underrepresentation of women surgeons in recognition awards at a single institution. Am J Surg 222(1):45-46, 2021. e-Pub 2021. PMID: 33384150.
- Lu PW, Shabat G, Semeniv S, Fedorkiv M, Fields AC, Lyu HG, Beznosenko A, Davids JS, Melnitchouk N. The Current Landscape of Staging and Treatment of Colorectal Cancer in a Region of Ukraine: a Mixed Methods Study. World J Surg 45(1):313-319, 2021. e-Pub 2021. PMID: 32978664.
- Lyu HG, Saadat LV, Bertagnolli MM, Wang J, Baldini EH, Stopfkuchen-Evans M, Bleday R, Raut CP. Enhanced recovery after surgery pathway in patients with soft tissue sarcoma. Br J Surg 107(12):1667-1672, 2020. e-Pub 2020. PMID: 32618371.
- Lyu HG, Raut CP. Enhanced recovery after surgery pathway in patients with soft tissue sarcoma. Br J Surg 107(11):e568, 2020. e-Pub 2020. PMID: 32866282.
- Kuo LE, Lyu HG, Jarman MP, Melnitchouk N, Doherty GM, Smink DS, Cho NL. Gender Disparity in Awards in General Surgery Residency Programs. JAMA Surg 156(1):60-6, 2020. e-Pub 2020. PMID: 32876660.
- Lyu H, Manca C, McGrath C, Beloff J, Plaks N, Postilnik A, Borchers A, Diaz N, McGovern S, Havens J, Kachalia A, Landman A. Development of a Web-Based Nonoperative Small Bowel Obstruction Treatment Pathway App. Appl Clin Inform 11(4):535-543, 2020. e-Pub 2020. PMID: 32814352.
- Lyu HG, Castillo-Angeles M, Bruno M, Cooper Z, Nehra D, Nitzschke SL, Askari R, Kelly E, Shimizu N, Riviello R, Salim A, Havens JM. Outcomes of a low-osmolar water-soluble contrast pathway in small bowel obstruction. J Trauma Acute Care Surg 87(3):630-635, 2019. e-Pub 2019. PMID: 31205220.
- Lyu HG, Davids JS, Scully RE, Melnitchouk N. Association of Domestic Responsibilities With Career Satisfaction for Physician Mothers in Procedural vs Nonprocedural Fields. JAMA Surg 154(8):689-695, 2019. e-Pub 2019. PMID: 30969336.
- Lyu HG, Faoro N, McDonald M, Jarman M, Kreitzman K, Salim A, Landman AB. Evaluation of RFID Technology to Capture Surgeon Arrival Time to Meet American College of Surgeons Committee on Trauma Verification Guidelines. ACI Open, 2019. e-Pub 2019.
- Davids JS, Lyu HG, Hoang CM, Daniel VT, Scully RE, Xu TY, Phatak UR, Damle A, Melnitchouk N. Female Representation and Implicit Gender Bias at the 2017 American Society of Colon and Rectal Surgeons' Annual Scientific and Tripartite Meeting. Dis Colon Rectum 62(3):357-362, 2019. e-Pub 2019. PMID: 30451743.
- Saadat LV, Fields AC, Lyu H, Urman RD, Whang EE, Goldberg J, Bleday R, Melnitchouk N. National Surgical Quality Improvement Program analysis of unplanned reoperation in patients undergoing low anterior resection or abdominoperineal resection for rectal cancer. Surgery 165(3):602-607, 2019. e-Pub 2019. PMID: 30309616.
- Rangel EL, Lyu H, Haider AH, Castillo-Angeles M, Doherty GM, Smink DS. Factors Associated With Residency and Career Dissatisfaction in Childbearing Surgical Residents. JAMA Surg 153(11):1004-1011, 2018. e-Pub 2018. PMID: 30073246.
- Melnitchouk N, Shabat G, Lu P, Lyu H, Scully R, Leung K, Jarman M, Lukashenko A, Kolesnik OO, Goldberg J, Davids JS, Bleday R. Colorectal Cancer in Ukraine: Regional Disparities and National Trends in Incidence, Management, and Mortality. J Glob Oncol 4:1-8, 2018. e-Pub 2018. PMID: 30354936.
- Lyu HG, Stein LA, Saadat LV, Phicil SN, Haider A, Raut CP, Dana-Farber/Brigham, Surgery Group WCCS. Assessment of the Accuracy of Disease Coding Among Patients Diagnosed With Sarcoma. JAMA Oncol 4(9):1293-1295, 2018. e-Pub 2018. PMID: 30098150.
- Lyu HG, Sharma G, Brovman EY, Ejiofor J, Urman RD, Gold JS, Whang EE. Unplanned reoperation after hepatectomy: an analysis of risk factors and outcomes. HPB (Oxford) 20(7):591-596, 2018. e-Pub 2018. PMID: 29331277.
- Lyu HG, Cooper MA, Mayer-Blackwell B, Jiam N, Hechenbleikner EM, Wick EC, Berenholtz SM, Makary MA. Medical Harm: Patient Perceptions and Follow-up Actions. J Patient Saf 13(4):199-201, 2017. e-Pub 2017. PMID: 25397856.
- Lyu HG, Sharma G, Brovman E, Ejiofor J, Repaka A, Urman RD, Gold JS, Whang EE. Risk Factors of Reoperation After Pancreatic Resection. Dig Dis Sci 62(6):1666-1675, 2017. e-Pub 2017. PMID: 28341868.
- Lyu H, Xu T, Brotman D, Mayer-Blackwell B, Cooper M, Daniel M, Wick EC, Saini V, Brownlee S, Makary MA. Overtreatment in the United States. PLoS One 12(9):e0181970, 2017. e-Pub 2017. PMID: 28877170.
- Lee D, Lyu H, Chung YH, Kim JA, Mathews P, Jaffee E, Zheng L, Yu E, Lee YJ, Ryu SH. Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma. World J Gastroenterol 22(23):5393-9, 2016. e-Pub 2016. PMID: 27340355.
- Beaulieu RJ, Grimm JC, Lyu H, Abularrage CJ, Perler BA. Rates and predictors of readmission after minor lower extremity amputations. J Vasc Surg 62(1):101-5, 2015. e-Pub 2015. PMID: 25827965.
- Cooper MA, Ibrahim A, Lyu H, Makary MA. Underreporting of robotic surgery complications. J Healthc Qual 37(2):133-8, 2015. e-Pub 2015. PMID: 23980819.
- Cooper MA, Hutfless S, Segev DL, Ibrahim A, Lyu H, Makary MA. Hospital level under-utilization of minimally invasive surgery in the United States: retrospective review. BMJ 349:g4198, 2014. e-Pub 2014. PMID: 25005264.
- Jiam NT, Cooper MA, Lyu HG, Hirose K, Makary MA. Surgical malpractice claims in the United States. J Healthc Risk Manag 33(4):29-34, 2014. e-Pub 2014. PMID: 24756827.
- Mathews P, Lee D, Chung YH, Kim JA, Lee JH, Jin YJ, Park W, Lyu H, Jaffee E, Zheng L, Yu E, Lee YJ. Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma. Ann Surg Oncol 20(4):1216-22, 2013. e-Pub 2013. PMID: 23104706.
- Lyu H, Wick EC, Housman M, Freischlag JA, Makary MA. Patient satisfaction as a possible indicator of quality surgical care. JAMA Surg 148(4):362-7, 2013. e-Pub 2013. PMID: 23715968.
- Lyu H, Lee D, Chung YH, Kim JA, Lee JH, Jin YJ, Park W, Mathews P, Jaffee E, Zheng L, Yu E, Lee YJ. Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma. J Viral Hepat 20(3):219-24, 2013. e-Pub 2013. PMID: 23383661.
- Guzzetta AA, Montgomery EA, Lyu H, Hooker CM, Meyer CF, Loeb DM, Frassica D, Weber KL, Ahuja N. Epithelioid sarcoma: one institution's experience with a rare sarcoma. J Surg Res 177(1):116-22, 2012. e-Pub 2012. PMID: 22575361.
Invited Articles
- Witt RG, Lyu HG, Keung EZ. The Past, Present, and Future: The Evolving Role and Challenges of Surgery in the Multimodal Management of Gastrointestinal Stromal Tumors. Gastrointestinal Stromal Tumor, 2023. e-Pub 2023.
- Lyu HG, Raut CP. What enhanced recovery means for patients with cancer undergoing surgery. Cancer 128(23):4058-4060, 2022. e-Pub 2022. PMID: 36219468.
- Lyu HG, Haider AH, Landman AB, Raut CP. The opportunities and shortcomings of using big data and national databases for sarcoma research. Cancer 125(17):2926-2934, 2019. e-Pub 2019. PMID: 31090929.
- Lyu HG, Najjar P, Havens JM. Past, present, and future of Emergency General Surgery in the USA. Acute Med Surg 5(2):119-122, 2018. e-Pub 2018. PMID: 29657721.
Review Articles
- Dunker, AM, Malik, N, Krause, KJ, Keung, EZ, Liu, JB, Nassif, EF, Somaiah, N, Lyu, H, Roland, CL. Health-Related Quality of Life in the Era of Immune Checkpoint Blockade. Cancers 17(24), 2025. e-Pub 2025. PMID: 41463169.
- Silva MA, See AP, Shah SK, Khandelwal P, Patel NJ, Lyu H, Menard MT, Aziz-Sultan MA. Endovascular Renal Artery Stent Retriever Embolectomy in a Young Patient With Cardiac Myxoma: Case Report and Review of the Literature. Vasc Endovascular Surg 52(1):70-74, 2018. e-Pub 2018. PMID: 29162028.
- Lyu H, Cooper M, Patel K, Daniel M, Makary MA. Prevalence and Data Transparency of National Clinical Registries in the United States. J Healthc Qual 38(4):223-34, 2016. e-Pub 2016. PMID: 26042745.
Other Articles
- Lewis, KA, Seldomridge, AN, Helmink, BA, Lyu, H, Snyder, RA Equity and Automation in Clinical Trial Screening. JCO Clinical Cancer Informatics 10(3), 2026. PMID: 42413065.
- Lyu H, Cooper M, Freischlag JA, Makary MA Patient satisfaction as a possible indicator of quality surgical care--reply. JAMA Surg 148(10):986-7, 2013. PMID: 24132398.
Editorials
- Lyu HG, Gordon WJ, Huey RW, Katz MHG. Leveraging the 21st Century Cures Act to Improve Cancer Care, Patient Engagement, and Data Collection. JCO Oncol Pract 18(12):788-790, 2022. PMID: 36219810.
- Gordon WJ, Ikoma N, Lyu HG, Purcell Jackson G, Landman AB. Protecting the Operating Room – Cybersecurity Considerations for Robotic Surgery. NPJ Digit Med 5(1):148, 2022.
- Gordon WJ, Ikoma N, Lyu HG, Purcell Jackson G, Landman AB. Protecting Procedural Care – Cybersecurity Considerations for Robotic Surgery. NPJ Digit Med 5(1):148, 2022.
- Lyu HG, Doherty GM, Landman AB. Surgical Informatics: Defining the Role of Informatics in the Current Surgical Training Paradigm. J Surg Educ 77(1):9-12, 2020. PMID: 31477548.
Abstracts
- Soewito, S, Lin, HY, Zoghbi, M, Pan, C, Young, P, Araujo, DM, Conley, AP, Livingston, JA, Ludwig, JA, Nakazawa, MS, Ratan, R, Ravi, V, Somaiah, N, Zarzour, MA, Patel, S, Meyer, LA, Soliman, PT, Lyu, H, Nassif, EF, Denu, RA. Doxorubicin-based chemotherapy vs gemcitabine/docetaxel in uterine leiomyosarcoma (ULMS) 43, 2025. e-Pub 2025.
- Hirata Y, To C, Lyu H, Smith GL, Samuel JP, Cao HST, Badgwell BD, Katz MHG, Ikoma N. ASO Visual Abstract: Prevalence of and Factors Associated with Financial Toxicity After Pancreatectomy and Gastrectomy. Ann Surg Oncol 31(7):4396, 2024. e-Pub 2024. PMID: 38735902.
- Lyu HG, Lu P, Mahvi DA, Kuo LEY, Wong SL, Raut CP, Cho NL. ASO Visual Abstract: Gender Disparities in Presentations at the Society of Surgical Oncology (SSO) Meetings from 2014 to 2019. Ann Surg Oncol 29(13):8115-8116, 2022. e-Pub 2022. PMID: 35902496.
Book Chapters
- Lyu H, Roland C. Resection of Desmoid Tumors and Other Fibromatosis. In: Difficult Decisions in Surgical Oncology, 2022.
- Lyu H, Clancy T. Pancreas. In: Doherty G, eds. Current Diagnosis & Treatment: Surgery, 15th edition. McGraw-Hill, 2020.
- Lyu H, Smink D. Stomach & Duodenum. In: Doherty G, eds. Current Diagnosis & Treatment: Surgery, 15th edition. McGraw-Hill, 2020.
- Lyu H, Irani J. Colectomy – Total and Subtotal. In: The SCORE Portal, 2018.
- Hardacre J, Lyu H. Appendix. In: Makary M, eds. Surgery Review. 3rd edition. Ladner-Drysdale, 2013.
- Lyu HG, Raut CP, Wong SL, Roland CL. Sarcomas of the Soft Tissue and Bone. In: Mulholland & Greenfield’s Surgery: Scientific Principles and Practice. Eighth.
- Lyu HG, Lilley E, Patel SS, Raut CP, Roland CL. Sarcomas of the Soft Tissues, Retroperitoneum, and Bone. In: Sabiston Textbook of Surgery. 22nd, 64.
Patient Reviews
CV information above last modified August 20, 2026