Hesham M. Amin, M.D., M.Sc.
Department of Hematopathology, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Professor, Department of Hematopathology, Division of Pathology-Lab Medicine Div, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Member of The Graduate Faculty, Department of Program in Cancer Biology and Program in Cell and Regulatory Biology, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 1990 | Faculty of Medicine, Cairo University, Cairo, EG, Clinical and Chemical Pathology, M.Sc |
| 1982 | Faculty of Medicine, Cairo University, Cairo, EG, Medicine and Surgery, M.B., B.Ch |
Postgraduate Training
| 2001-2002 | Fellow, Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2000-2001 | Fellow, Hematopathology, Loyola University Medical Center, Maywood, Illinois |
| 1997-2000 | Resident, Anatomic and Clinical Pathology, Loyola University Medical Center, Maywood, Illinois |
| 1996-1997 | Resident, Anatomic and Clinical Pathology, George Washington University Medical Center, Washington, DC |
| 1990-1996 | Fellow, Physiology and Pharmacology, State University of New York Upstate Medical University, Syracuse, New York |
| 1986-1990 | Resident, Clinical and Chemical Pathology, Theodor Bilharz Research Institute, Giza |
| 1985-1986 | Resident, Obstetrics and Gynecology, Suez Canal University, Ismalia |
| 1983-1984 | Intern, Cairo University, Cairo |
Licenses & Certifications
| 2003 | American Board of Pathology, Hematology |
| 2002 | American Board of Pathology, Anatomic and Clinical Pathology |
| 2002 | Texas Medical License |
| 2001 | Texas Physician-in-Training Permit |
| 2000 | Illinois Medical License |
| 1997 | Temporary Illinois Medical License |
| 1993 | Pennsylvania FLEX |
| 1993 | ECFMG |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2007 - 2013
Assistant Professor, Tenure Track, Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2002 - 2007
Assistant Lecturer, Department of Laboratory Hematology, Theodor Bilharz Research Institute, Giza, 1991 - 1995
Research Fellow/Research Associate, Department of Anesthesiology, State University of New York Upstate Medical University, Sycaruse, NY, 1990 - 1996
Assistant Researcher, Department of Laboratory Hematology, Theodor Bilharz Research Institute, Giza, 1990 - 1991
Other Professional Positions
Consultantships, Gerson Lehrman Group, New York, 2004 - 2008
Extramural Institutional Committee Activities
Member, Research Development Committee, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Academic Mentoring Council Chairs Task Force, The University of Texas MD Anderson Cancer Center, 2024 - 2024
Member, Senior Faculty Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Working Group on Mentorship, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Strategic Operational Priority Committee, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, 2021 Alfred G. Knudson, Jr., Dissertation Award Selection Panel, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 2022 - 2022
Member, Clinical Research Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Service Schedule Committee, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 2021 - 2022
Member, Diversity, Equality, and Inclusion (DEI) Committee, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 2021 - 2022
Member, Patient Care Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Tenure-Track Faculty Mentoring Committee, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Research Laboratory Space and Equipment Committee, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Education Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Education Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2019 - Present
Member, Basic Research Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2018 - Present
Member, Basic Research Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2017 - Present
Member, "Big Survey" Working Group, Faculty Senate, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2016 - 2016
Member, Faculty Achievement Award Committee, Faculty Senate, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2016 - 2022
Member, Education Award Subcommittee, The University of Texas MD Anderson Cancer Center, 2016 - Present
Member, Cancer Network Research Committee, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2014 - 2016
Member, Member, Candidacy Examination Standing Committee, Program in Cell and Regulatory Biology, The University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2013 - Present
Member, Institutional Biosafety Committee, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2013 - Present
Member, Candidacy Examination Standing Committee, Program in Cancer Biology, The University of Texas M. D. Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2013 - 2016
Member, Mentorship Committee for Joseph A. Ludwig, M.D., Assistant Professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2012 - 2013
Member, Cancer Survivorship Seed Money Grant Review Committee, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2012 - 2015
Member, Ad Hoc Committee for the Revision of Research Compliance Plan, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2011 - 2012
Member, Scientific Review Committee, Sister Institution Network Fund, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2011 - 2014
Member, Communication/Shared Governance/Transparency/Accountability Focus Group, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2011 - 2015
Member, Bylaws Committee, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2010 - Present
Member, Mid-Tenure Review Committee for Joseph A. Ludwig, M.D., Assistant Professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2010 - Present
Member, Mid-Tenure Review Committee for Roberto N. Miranda, M.D., Associate Professor, Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2010 - Present
Member, Ad Hoc Committee for Management Strategic Goals (Review and modification of Management Committee’s Draft of Strategic Goals for “Making Cancer History”), Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2010 - Present
Chairman, Study Section Review Committee for Clinical, Translational, and Population-Based Research Projects, Institutional Research Grant Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2009 - 2010
Vice Chairman, Study Section Review Committee for Clinical, Translational, and Population-Based Research Projects, Institutional Research Grant Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2008 - 2009
Ad Hoc Member, Institutional Research Grant Oversight Committee, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2008 - 2010
Member, MD/PhD Program Committee, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2008 - 2009
Member, Multidisciplinary Care Center Scientific Steering Committee, Institute for Personalized Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2008 - 2011
Member, Study Section Review Committee for Clinical, Translational, and Population-Based Research Projects, Institutional Research Grant Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2007 - 2008
Member, Research Affairs Committee, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2006 - Present
Member, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2006 - 2018
Member, Scientific Publications Advisory Board, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2006 - Present
Member, Institutional Animal Care and Use Committee, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, The University of Texas MD Anderson Cancer Center, 2006 - 2009
Member, Faculty Recruiting Committee, Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2006 - 2007
Member, Faculty Recruiting Committee, Department of Lymphoma and Myeloma, Division of Cancer, The University of Texas MD Anderson Cancer Center, 2006 - 2007
Editorial Activities
Assistant Editor, Journal of Cellular and Molecular Medicine, 2008 - Present
Honors & Awards
| 2019 | The Short Talk Award for An Exceptional Oral Presentation, Federation of American Societies for Experimental Biology |
| 2011 | Distinguished Alumnus, Department of Pathology, Loyola University Medical Center, Maywood, Illinois |
| 1995 | Al-Razi Award for best paper published by a resident, The Arab American Medical Association, Washington, DC |
| 1993 | Award of Excellence, The 4th Annual Upstate Academic Anesthesiology Conference, Rochester, New York |
| 1991 | Award of Excellence, The 2nd Annual Upstate Academic Anesthesiology Conference, Rochester, New York |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2023. Structured mentoring: luxury or necessity?. Invited. Faculty Strategic Planning Retreat. Houston, Texas, US.
- 2023. Project 3: Targeting growth hormone receptor in unresectable hepatocellular carcinoma. Invited. Hepatocellular Carcinoma SPORE Advisory Board Meeting. Houston, Texas, US.
- 2022. Growth hormone receptor: a functional therapeutic target in hepatocellular carcinoma. Invited. Hepatocellular Carcinoma SPORE Monthly Conference. Houston, Texas, US.
- 2022. Growth hormone receptor signaling in hepatocellular carcinoma. Invited. Hepatocellular Carcinoma SPORE Monthly Conference. Houston, Texas, US.
- 2021. Growth hormone receptor signaling: from metabolism to cancer. Invited. Grand Rounds. Houston, Texas, US.
- 2015. Growth hormone receptor signaling in hepatocellular carcinoma. Invited. Houston, TX, US.
- 2014. ALK+ lymphoma: what we have learned from a rare cancer. Invited. Grand Rounds. Houston, TX, US.
- 2013. Updates on the pathogenesis of NPM-ALK+ T-cell lymphoma. Invited. Department of Hematopathology Fellows Meeting. Houston, TX, US.
- 2013. NPM-ALK: novel molecular interactions that determine its oncogenic potential in T-cell lymphoma. Invited. Leukemia Department Research Meeting. Houston, TX, US.
- 2011. Regulatory mechanisms of survival signaling in malignant lymphoma. Invited. Leukemia/Lymphoma Group Meeting. Houston, TX, US.
- 2010. NPM-ALK signaling network: an intriguing model for developing cancer therapeutics. Invited. Hematology Grand Rounds. Houston, TX, US.
- 2010. NPM-ALK and IGF-IR: old tyrosine kinases with new oncogenic potentials. Invited. Advances in Oncology Institutional Grand Rounds. Houston, TX, US.
- 2009. IGF-I receptor tyrosine kinase signaling in cancer: is it time for lymphoma and leukemia?. Invited. Grand Rounds. Houston, TX, US.
- 2009. IGF-IR tyrosine kinase: a potential target in imatinib-resistant chronic myeloid leukemia. Invited. Leukemia Department Research Meeting. Houston, TX, US.
- 2009. IGF-IR: a potential molecular target in lymphoma and leukemia. Invited. Leukemia/Lymphoma Group Meeting. Houston, TX, US.
- 2009. Functional interactions between IGF-IR tyrosine kinase and NPM-ALK oncogene in T-cell lymphoma. Invited. Physicians and Investigators in Research Studies Meeting. Houston, TX, US.
- 2009. Type I insulin-like growth factor receptor signaling in lymphoma and leukemia. Invited. Large B-cell Lymphoma Research Retreat. Houston, TX, US.
- 2008. IGF-IR as a potential molecular target in ALK+ anaplastic large-cell lymphoma. Invited. Clinical Trials Faculty Meeting. Houston, TX, US.
- 2007. Current advances in the biology of ALK+ anaplastic large cell lymphoma. Invited. Physicians and Investigators in Research Studies Meeting. Houston, TX, US.
- 2005. Jak3/Stat3 signaling in colon carcinoma. Invited. Colon Cancer Working Group Meeting. Houston, TX, US.
- 2005. JAK3: is it Just Another Kinase?. Invited. Grand Rounds. Houston, TX, US.
Regional Presentations
- 2023. Project 3: Targeting growth hormone receptor in unresectable hepatocellular carcinoma. Invited. SPORE Special Emphasis Panel on GI and Liver Cancers. Bethesda, Maryland, US.
- 1998. Primitive neuroectodermal tumor of the kidney. Conference. Illinois Registry of Anatomic Pathology Meeting. Chicago, IL, US.
- 1994. Red blood cell responses to hyperoxia. Conference. SUNY Upstate Medical University, Department of Anesthesiology Annual Meeting. Syracuse, NY, US.
- 1993. Reliability of transcutaneous oxygen measurement in monoplace chambers. Conference. The 4th Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1993. Blood alterations following acute exposure to hyperbaric oxygen and 24 hours of recovery in rats. Conference. The 4th Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1992. Oxygen toxicity and blood viscosity. Conference. SUNY Upstate Medical University, Department of Anesthesiology Annual Meeting. Syracuse, NY, US.
- 1992. Methylnaltrexone does not reverse morphine-mediated ventilatory depression. Conference. The 3rd Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1992. Blood viscosity changes after acute exposure to hyperbaric oxygen and 24 hours of recovery in rats. Conference. The 3rd Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1991. Respiratory analysis system. Conference. The 2nd Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1991. HBO toxicity (2.8 ata for 6 hours) in rats' lungs. Conference. The 2nd Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
- 1991. Postoperative pain control by transdermal fentanyl. Conference. The 2nd Annual Upstate Academic Anesthesiology Conference. Rochester, NY, US.
National Presentations
- 2022. Disruption of growth hormone receptor gene expression abrogates hepatocellular carcinoma development and progression. Conference. Growth Hormone/Prolactin Family in Biology & Disease Conference. Athens, Ohio, US.
- 2019. Blockade of growth hormone receptor signaling as an effective strategy to eradicate hepatocellular carcinoma. Conference. Growth Hormone/Prolactin Family in Biology & Disease Conference. West Palm Beach, Florida, US.
- 2014. SUMOylation sustains the stability of NPM-ALK oncogenic protein and facilitates its nuclear accumulation in T-cell anaplastic large-cell lymphoma. Conference. ASH 56th Annual Meeting and Exposition. San Francisco, CA, US.
- 2014. Decreased levels of the transcription factors Ik-1 and MZF1 contribute to upregulation of IGF-IR expression in NPM-ALK+ T-cell anaplastic large-cell lymphoma. Conference. Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies. Philadelphia, PA, US.
- 2011. NPM-ALK oncogene upregulates the expression of inducible nitric oxide synthase in T-cell lymphoma through a STAT3/microRNA-26a-dependent mechanism. Conference. ASH 53rd Annual Meeting and Exposition. San Diego, CA, US.
- 2011. MicroRNA-96 is a posttranscriptional suppressor of anaplastic lymphoma kinase expression in human cancer. Conference. AACR 102nd Annual Meeting. Orlando, FL, US.
- 2007. Intrasinusoidal infiltration is more frequent in splenic marginal zone lymphoma, but lymphoid follicle formation is common in all types of marginal zone lymphoma. Conference. USCAP 96th Annual Meeting. San Diego, CA, US.
- 2004. Increased bone marrow erythroid precursors is associated with shorter survival in low-grade myelodysplastic syndromes. Conference. ASH 46th Annual Meeting and Exposition. San Diego, CA, US.
- 2004. Multilineage dysplasia is associated with worse clinical outcome independent of the diagnosis of acute myeloid leukemia or myelodysplastic syndrome. Conference. ASH 46th Annual Meeting and Exposition. San Diego, CA, US.
- 2003. Clinical relevance of peripheral blood blasts in the myelodysplastic syndrome. Conference. ASH 45th Annual Meeting & Exposition. San Diego, CA, US.
- 2002. The plasma cell variant of Castleman’s disease lacks uniform histologic and clinical features. Conference. USCAP 91st Annual Meeting. Chicago, IL, US.
- 2002. Histone deacetylase inhibitors induce caspase-dependent apoptosis in acute promyelocytic leukemia with t(15;17). Conference. USCAP 91st Annual Meeting. Chicago, IL, US.
- 2000. Analysis of Bcl-6 protein in primary B-cell non-Hodgkin’s lymphomas (B-NHLs) involving the gastrointestinal (GI) tract. Conference. USCAP 89th Annual Meeting. New Orleans, LA, US.
- 2000. Characterization of apoptosis induced by protein kinase C inhibitors in retinoic acid sensitive and resistant acute promyelocytic leukemia cell line, NB4. Conference. USCAP 89th Annual Meeting. New Orleans, LA, US.
- 1998. Primary malignant melanoma of the larynx. Conference. AAO-HNSF Annual Meeting. San Antonio, TX, US.
- 1998. Quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. Conference. Experimental Biology 98 Conference. San Francisco, CA, US.
- 1998. Immuno-quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. Conference. The 50th Anniversary of the American Association of Clinical Chemistry. Chicago, IL, US.
- 1996. Effect of exposure to hyperbaric oxygen on nitric oxide production in the rat. Conference. ASBMB/ASIP/AAI Joint Meeting. New Orleans, LA, US.
- 1996. Effect of different durations of exposure to hyperbaric oxygen on circulating prostacyclin in the rat. Conference. UHMS Annual Scientific Meeting. Anchorage, AK, US.
- 1996. Effect of desferrioxamine versus PEG-superoxide dismutase on increased prostacyclin (PGI2) concentration after acute exposure to hyperbaric oxygen. Conference. Experimental Biology 96 Conference. Washington, DC, US.
- 1995. Effects of exposure to hyperbaric oxygen on blood rheology in the rat. Conference. UHMS Annual Scientific Meeting. Palm Beach, FL, US.
- 1995. Effect of acute exposure to hyperbaric oxygen and 24 hours of recovery on prostacyclin concentration. Conference. Experimental Biology 95 Conference. Atlanta, GA, US.
- 1994. Small doses of midazolam do not depress the ventilatory responses to progressively induced hypoxia. Conference. ASA 1994 Annual Meeting. San Francisco, CA, US.
- 1994. Changes in the plasma proteins following acute exposure to hyperbaric oxygen and 24 hours of recovery in rats. Conference. UHMS Annual Scientific Meeting. Denver, CO, US.
- 1994. Acute exposure to hyperbaric oxygen decreases the deformability of the red blood cells. Conference. UHMS Annual Scientific Meeting. Denver, CO, US.
- 1994. Hematologic changes during isovolemic hemodilution with human albumin, hetastarch or pentastarch in domestic pigs. Conference. Experimental Biology 94 Conference. Anaheim, CA, US.
- 1994. Blood alterations after acute hyperbaric oxygen [HBO] exposure. Conference. 23rd Critical Care Congress. Orlando, FL, US.
- 1993. Naloxone reversal of depressed ventilatory response to hypoxia during continuous infusion of remifentanil. Conference. ASA 1993 Annual Meeting. Washington, DC, US.
- 1993. Methylnaltrexone does not reverse morphine-induced depression of hypoxic drive. Conference. ASA 1993 Annual Meeting. Washington, DC, US.
- 1993. Changes in blood rheology following acute exposure to hyperbaric oxygen (HBO). Conference. Experimental Biology 93 Conference. New Orleans, LA, US.
- 1992. Blood viscosity increases after acute hyperbaric oxygen (HBO) exposure. Conference. ASA 1992 Annual Meeting. New Orleans, LA, US.
- 1992. Pulmonary vascular responses after acute hyperbaric oxygen (HBO) exposure. Conference. ASA 1992 Annual Meeting. New Orleans, LA, US.
- 1992. Pulmonary mechanical responses after hyperbaric O2 (HBO) exposure and 24 hours of recovery in rats. Conference. UHMS Annual Scientific Meeting. Washington, DC, US.
- 1992. Blood viscosity changes after exposure to hyperbaric O2 (HBO) in rats. Conference. UHMS Annual Scientific Meeting. Washington, DC, US.
- 1991. Lung mechanics after short exposure to hyperbaric oxygen (HBO) in rats. Conference. UHMS Annual Scientific Meeting. San Diego, CA, US.
- 1991. Pulmonary vasculature after short exposure to hyperbaric oxygen (HBO) in rats. Conference. UHMS Annual Scientific Meeting. San Diego, CA, US.
International Presentations
- 2010. NPM-ALK+ T-cell lymphoma as a model for developing cancer therapeutics. Invited. 2nd International Conference on Drug Discovery and Therapy. Dubai, AE.
- 2008. IGF-IR tyrosine kinase signaling in hematological malignancies. Invited. The 11th Annual Meeting of the Chinese Society of Clinical Oncology. Shanghai, CN.
- 2007. Functional interactions between IGF-IR tyrosine kinase and NPM-ALK oncogene identify IGF-IR signaling as a therapeutic target in T-cell ALK-positive anaplastic large-cell lymphoma. Conference. Making Connections: A Canadian Cancer Research Conference Celebrating NCIC’s 60th Anniversary. Toronto, CA.
- 2004. Inhibition of JAK3-STAT3 signaling pathway induces apoptosis and cell cycle arrest in human colon carcinoma cells. Conference. Keystone Symposia, Jaks and Stats: Development to Disease. Whistler, CA.
- 2004. Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Conference. Keystone Symposia, Jaks and Stats: Development to Disease. Whistler, CA.
- 1999. Immuno-quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. Conference. XVII ISTH Congress. Washington, US.
- 1997. Stability of four different thromboplastin reagents over 24 hours at 18°C. Conference. The XVIth ISTH Congress. Florence, IT.
- 1993. Hematological changes following acute exposure to hyperbaric oxygen (HBO) and 24 hours of recovery in rats. Conference. UHMS Annual Scientific Meeting. Halifax, CA.
- 1990. Vitamin K-dependent coagulation proteins in chronic liver diseases. Conference. The 8th Annual ESHGID Congress. Cairo, EG.
- 1989. Vitamin K-dependent coagulation proteins in hepatosplenic schistosomiasis. Conference. The 7th Annual ESHGID Congress. Cairo, EG.
Formal Peers
- 2024. Hepatocellular carcinoma: an ideal mouse model. Houston, Texas, US.
- 2024. HCC: In search of an ideal mouse model. Houston, Texas, US.
- 2023. NASH-fibrosis-HCC immunocompetent mouse model. Houston, Texas, US.
- 2023. HCC: In search of an ideal mouse model. Houston, Texas, US.
- 2023. NASH-HCC immunocompetent mouse model. Houston, Texas, US.
- 2022. Growth hormone receptor and mouse models in HCC. Houston, Texas, US.
- 2017. Novel strategies for treatment of aggressive neoplasms. Athens, Ohio, US.
- 2013. ALK-expressing T-cell lymphoma: clinicopathological and biological updates. Invited. Galveston, TX, US.
- 2013. Anaplastic lymphoma kinase: molecular interactions and regulatory mechanisms that determine its oncogenic potential. Invited. Duarte, CA, US.
- 2012. Novel regulatory mechanisms for the survival of anaplastic large-cell lymphoma cells. Invited. Houston, TX, US.
- 2012. NPM-ALK-expressing T-cell lymphoma as a model for cancer pathogenesis. Invited. Toronto, Ontario, CA.
- 2012. Role of insulin receptor superfamily in cancer: NPM-ALK-expressing T-cell lymphoma as a clinicopathological model. Invited. Omaha, NE, US.
- 2012. New insights into the pathogenesis of NPM-ALK-expressing T-cell lymphoma. Invited. Shanghai, CN.
- 2011. ALK and IGF-IR: novel interactions and regulatory mechanisms that determine their role in cancer. Invited. Pittsburgh, PA, US.
- 2011. Targeting survival systems in malignant lymphoma: from bench to bedside. Invited. Maywood, IL, US.
- 2011. Philadelphia chromosome-negative myeloproliferative neoplasms. Invited. Maywood, IL, US.
- 2010. Novel oncogenic systems in lymphoma. Invited. Shanghai, CN.
- 2009. IGF-IR tyrosine kinase signaling in lymphoma and leukemia. Invited. Houston, TX, US.
- 2008. Role of type I insulin-like growth factor receptor tyrosine kinase in lymphoma and leukemia. Invited. Houston, TX, US.
- 2008. ALK-positive anaplastic large-cell lymphoma: biological and translational considerations. Invited. Worcester, MA, US.
- 2006. Janus kinase 3: a double-faced tyrosine kinase. Invited. Princeton, NJ, US.
Grant & Contract Support
| Date: | 2021 - 2023 |
| Title: | An open-label, phase II, pre-operative study of atezolizumab plus bevacizumab for resectable hepatocellular carcinoma |
| Funding Source: | Genentech-Roche |
| Role: | Co-PI |
| Date: | 2020 - 2023 |
| Title: | Effects of combined growth hormone receptor inhibition and immunosuppression in hepatocellular carcinoma |
| Funding Source: | Merck & Co |
| Role: | PI |
| Date: | 2018 - 2020 |
| Title: | Role of growth hormone receptor signaling in hepatocellular carcinoma |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| Date: | 2017 - 2019 |
| Title: | Characterization of Gas6/Axl signaling in hepatocellular carcinoma |
| Funding Source: | Aravive Biologics |
| Role: | PI |
| Date: | 2017 - 2021 |
| Title: | Characterization and effects of inhibition of Gas6/Axl signaling in cancer |
| Funding Source: | Aravive Biologics |
| Role: | PI |
| Date: | 2017 - 2022 |
| Title: | Role and therapeutic potential of GHR in hepatocellular carcinoma |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | R01-CA222302 |
| Date: | 2016 - 2024 |
| Title: | Effects of growth hormone receptor antagonism with and without sorafenib in hepatocellular carcinoma |
| Funding Source: | Pfizer |
| Role: | PI |
| Date: | 2014 - 2019 |
| Title: | Three-dimensional model of human Ewing sarcoma |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | CA180279 |
| Date: | 2011 - 2016 |
| Title: | Role of IGF-IR tyrosine kinase in NPM-ALK-expressing T-cell lymphoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA151533 |
| Date: | 2011 |
| Title: | Role of IGF-IR tyrosine kinase in NPM-ALK-expressing T-cell lymphoma |
| Funding Source: | Bridge Funding, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| Role: | PI |
| Date: | 2010 - 2015 |
| Title: | A phase I open-label, non-randomized, dose-escalation first-in-man trial to investigate the c-Met kinase inhibitor EMD 1214063 under two different regimens in subjects with advanced solid tumors |
| Funding Source: | EMD Serono, Rockland, Massachusetts |
| Role: | Co-I |
| Date: | 2009 - 2013 |
| Title: | Oncogenic network of ALK-positive anaplastic large cell lymphoma |
| Funding Source: | National Cancer Institute of Canada, Toronto, Ontario, Canada |
| Role: | Co-I |
| Date: | 2007 - 2012 |
| Title: | Role of redox dependent signaling in leukemia |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA115811 |
| Date: | 2007 - 2011 |
| Title: | ALK-expressing T/null-cell lymphoma: pathogenesis and novel therapeutics |
| Funding Source: | Institute of Cancer Research/Canadian Institutes for Health Research, Montreal, Quebec, Canada |
| Role: | Co-I |
| Date: | 2007 - 2009 |
| Title: | Open, randomized comparative trial of two different schedules of liposomal amphotericin B versus oral voriconazole for the prevention of invasive fungal infections |
| Funding Source: | Novartis Pharmaceuticals, St. Louis, Missouri |
| Role: | Co-I |
| Date: | 2006 - 2011 |
| Title: | Role of Jak3 in anaplastic large cell lymphoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | K08CA114395 |
| Date: | 2006 - 2007 |
| Title: | Evaluation of Jak3 inhibitors in hematologic neoplasms |
| Funding Source: | Pharmacopeia Drug Discovery, Princeton, New Jersey |
| Role: | PI |
| Date: | 2005 - 2007 |
| Title: | Identifying a novel role of Janus kinase 3 in colon carcinoma |
| Funding Source: | Institutional Research Grant, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| Role: | PI |
| Date: | 2005 - 2008 |
| Title: | Biological and clinical significance of STAT3 in mantle cell lymphoma |
| Funding Source: | National Cancer Institute of Canada, Toronto, Ontario, Canada |
| Role: | Co-I |
| Date: | 2005 - 2010 |
| Title: | Pathogenetic role of JAK3 in ALK+ anaplastic large cell lymphoma |
| Funding Source: | The Physician Scientist Program Award, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| Role: | PI |
| Date: | 2003 - 2005 |
| Title: | Pathogenetic role of JAK3-STAT3 signaling in p210 BCR-ABL-positive chronic myelogenous leukemia |
| Funding Source: | Career Developing Award from the National Institutes of Health Leukemia SPORE Grant, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| Role: | PI |
| Date: | 2002 - 2005 |
| Title: | Startup Fund |
| Funding Source: | The University of Texas M. D. Anderson Cancer Center |
| Role: | PI |
| Date: | 2001 - 2002 |
| Title: | The biologic effects of AG490, a specific inhibitor of Janus kinase, in mantle cell lymphoma |
| Funding Source: | Research Funding for Fellows, Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| Role: | PI |
| Date: | 1991 - 1993 |
| Title: | Naloxone reversal of depressed ventilatory response to hypoxia during continuous infusion of remifentanil and alfentanil in healthy adult males |
| Funding Source: | Glaxo Research Institute, Research Triangle Park, North Carolina |
| Role: | Co-I |
| Date: | 1991 - 1992 |
| Title: | Comparative effectiveness of 10% pentastarch in maintaining hemodynamic stability and oxygen delivery in a pig model of hemorrhagic shock |
| Funding Source: | Hendricks Fund for Medical Research and Department of Anesthesiology, State University of New York Upstate Medical University, Syracuse, New York |
| Role: | Co-I |
Selected Publications
Peer-Reviewed Articles
- Eid, JR, Haddad, A, Hassan, MM, Amin, H, Newhook, TE, Chun, YS, Tzeng, CD, Vauthey, JN, Tran Cao, HS, Kaseb, A. Evaluating the role of preoperative serum insulin-like growth factor 1 as a predictor of survival and recurrence for patients with resectable hepatocellular carcinoma. Journal of Gastrointestinal Surgery 30(1), 2026. e-Pub 2026. PMID: 41197829.
- Eid J, Haddad A, Hassan M, Amin HM, Newhook TE, Chun YS, Tzeng CD, Vauthey JN, Tran Cao HS, Kaseb AO. Evaluating the role of preoperative serum insulin-like growth factor 1 as a predictor of survival and recurrence for patients with resectable hepatocellular carcinoma. J Gastrointest Surg 30(1):102275, 2026. e-Pub 2026. PMID: 41197829.
- Eid JR, Yalciner M, Siddiqui ZA, Xiao L, Sun R, Kumar Kannan M, Hassan M, Rashid A, Tran Cao HS, Vauthey JN, Amin HM, Palaskas NL, Shalapour S, Kaseb AO. Impact of reninangiotensin-aldosterone axis inhibitors on survival and progression in hepatocellular carcinoma patients receiving immunotherapy. e-Pub 2025.
- Eid JR, Yalciner M, Xiao L, Sun R, Kannan MK, Hassan M, Rashid A, Chamseddine S, Tran Cao HS, Amin HM, Kaseb AO. Circulating Fibroblast Growth Factor 21 (FGF21) as a Prognostic and Diagnostic Biomarker in Hepatocellular Carcinoma. J Hepatocell Carcinoma 12:2709-2722, 2025. e-Pub 2025. PMID: 41399394.
- Chamseddine, SM, Yavuz, BG, Mohamed, Y, Lee, SS, Yao, JC, Hu, Z, Lapelusa, M, Xiao, L, Sun, R, Morris, JS, Hatia, RI, Hassan, MM, Duda, DG, Diab, M, Mohamed, A, Nassar, A, Amin, H, Kaseb, A. Circulating Tumor DNA (ctDNA) as a biomarker of response to therapy in advanced hepato cellular Galectin-3 carcinoma treated with Nivolumab. Journal of Immunotherapy and Precision Oncology 7(4):255-262, 2024. e-Pub 2024. PMID: 39524465.
- Hassan, MM, Li, D, Han, Y, Byun, J, Hatia, RI, Long, E, Choi, J, Kelley, RK, Cleary, S, Lok, AS, Bracci, PM, Permuth, JB, Bucur, R, Yuan, JM, Singal, AG, Jalal, P, Ghobrial, RM, Santella, RM, Kono, Y, Shah, DJ, Nguyen, MH, Liu, G, Parikh, ND, Kim, RD, Wu, HC, El-Serag, H, Chang, P, Li, Y, Chun, YS, Lee, SS, Gu, J, Hawk, E, Sun, R, Huff, C, Rashid, A, Amin, H, Beretta, L, Wolff, RA, Antwi, SO, Patt, YZ, Hwang, LY, Klein, AP, Zhang, K, Schmidt, MA, White, DL, Goss, JA, Khaderi, SA, Marrero, JA, Cigarroa, FG, Shah, PK, Kaseb, A, Roberts, LR, Amos, CI. Genome-wide association study identifies high-impact susceptibility loci for HCC in North America. Hepatology 80(1):87-101, 2024. e-Pub 2024. PMID: 38381705.
- Chamseddine, SM, Lapelusa, M, Carter, K, Nguyen, V, Mohamed, YI, Sakr, Y, Rojas Hernandez, CM, Hatia, RI, Hassan, MM, Goss, JA, Elsayes, KM, Rashid, A, Sun, R, Cao, HT, Amin, H, Kaseb, A. Severe febrile neutropenia and pancytopenia in a patient with advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab. Journal of Gastrointestinal Oncology 15(3):1324-1330, 2024. e-Pub 2024. PMID: 38989410.
- He, W, Li, Y, Liu, S, Chang, Y, Han, S, Han, X, Ma, Z, Amin, H, Song, YH, Zhou, J. From mitochondria to tumor suppression. Frontiers in immunology 15, 2024. e-Pub 2024. PMID: 39247186.
- Chamseddine, SM, Lapelusa, M, Xiao, L, Mohamed, YI, Lee, SS, Hu, Z, Hatia, RI, Hassan, MM, Yao, JC, Duda, DG, Datar, S, Amin, H, Kaseb, A. Plasma Growth Hormone as a Prognostic Biomarker to Durvalumab and Tremelimumab in Patients with Advanced Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma 11:455-461, 2024. e-Pub 2024. PMID: 38463542.
- Chamseddine, SM, Mohamed, Y, Lee, SS, Yao, JC, Hu, Z, Tran Cao, HS, Xiao, L, Sun, R, Morris, J, Hatia, RI, Hassan, MM, Duda, DG, Diab, M, Mohamed, A, Nassar, A, Datar, S, Amin, H, Kaseb, A. Clinical and Prognostic Biomarker Value of Blood-Circulating Inflammatory Cytokines in Hepatocellular Carcinoma. Oncology (Switzerland) 101(11):730-737, 2023. e-Pub 2023. PMID: 37467732.
- Lou, J, Geng, S, He, W, Liu, S, Shi, X, Chang, Y, Han, S, Qian, P, Amin, H, Song, YH, Li, Y, Zhou, J. Zyxin inhibits the epithelial–mesenchymal transition process in gastric cancer by upregulating SIRT1. MedComm 4(5), 2023. e-Pub 2023. PMID: 37667739.
- Saber, MM, Mahmoud, MM, Amin, H, Essam, RM. Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model. Biomedicine and Pharmacotherapy 166, 2023. e-Pub 2023. PMID: 37573656.
- Mohamed, Y, Duda, DG, Awiwi, M, Lee, SS, Altameemi, L, Xiao, L, Morris, JS, Wolff, RA, Elsayes, KM, Hatia, RI, Qayyum, A, Chamseddine, SM, Rashid, A, Yao, JC, Mahvash, A, Hassan, MM, Amin, H, Kaseb, A. Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients. Oncotarget 13(1):1314-1321, 2022. e-Pub 2022. PMID: 36473155.
- Wang Z, Kaseb AO, Amin HM, Hassan MM, Wang W, Morris JS. Bayesian Edge Regression in Undirected Graphical Models to Characterize Interpatient Heterogeneity in Cancer. J Am Stat Assoc 117(538):533-546, 2022. e-Pub 2022. PMID: 36090952.
- George B, Haque A, Sahu V, Joldoshova A, Singh Y, Quinones JE, George SK, Amin HM. Enhancing Antigen Retrieval to Unmask Signaling Phosphoproteins in Formalin-fixed Archival Tissues. Appl Immunohistochem Mol Morphol 30(5):333-339, 2022. e-Pub 2022. PMID: 35510772.
- Haque A, Sahu V, Lombardo JL, Xiao L, George B, Wolff RA, Morris JS, Rashid A, Kopchick JJ, Kaseb AO, Amin HM. Disruption of Growth Hormone Receptor Signaling Abrogates Hepatocellular Carcinoma Development. J Hepatocell Carcinoma 9:823-837, 2022. e-Pub 2022. PMID: 35996397.
- Kaseb AO, Haque A, Vishwamitra D, Hassan MM, Xiao L, George B, Sahu V, Mohamed YI, Carmagnani Pestana R, Lombardo JL, Avritscher R, Yao JC, Wolff RA, Rashid A, Morris JS, Amin HM. Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma. Front Oncol 12:986305, 2022. e-Pub 2022. PMID: 36276070.
- Subbiah V, Kuravi S, Ganguly S, Welch DR, Vivian CJ, Mushtaq MU, Hegde A, Iyer S, Behrang A, Ali SM, Madison RW, Venstrom JM, Jensen RA, McGuirk JP, Amin HM, Balusu R. Precision therapy with anaplastic lymphoma kinase inhibitor ceritinib in ALK-rearranged anaplastic large cell lymphoma. ESMO Open 6(4):100172, 2021. e-Pub 2021. PMID: 34242968.
- Morris JS, Hassan MM, Zohner YE, Wang Z, Xiao L, Rashid A, Haque A, Abdel-Wahab R, Mohamed YI, Ballard KL, Wolff RA, George B, Li L, Allen G, Weylandt M, Li D, Wang W, Raghav K, Yao J, Amin HM, Kaseb AO. HepatoScore-14: Measures of Biological Heterogeneity Significantly Improve Prediction of Hepatocellular Carcinoma Risk. Hepatology 73(6):2278-2292, 2021. e-Pub 2021. PMID: 32931023.
- Mohamed YI, Lee S, Xiao L, Hassan MM, Qayyum A, Hiatia R, Pestana RC, Haque A, George B, Rashid A, Duda DG, Elghazaly H, Wolff RA, Morris JS, Yao J, Amin HM, Kaseb AO. Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib. Oncotarget 12(8):756-766, 2021. e-Pub 2021. PMID: 33889299.
- Lacin S, Yalcin S, Karakas Y, Hassan MM, Amin HM, Mohamed YI, Rashid A, Morris JS, Xiao L, Qayyum A, Kaseb AO. Prognostic Significance of Serum Insulin-Like Growth Factor-1 in Hepatocellular Cancer Patients: A Validation Study. J Hepatocell Carcinoma 7:143-153, 2020. e-Pub 2020. PMID: 32984091.
- Wang B, Zheng J, Chen Q, Wu C, Li Y, Yu XY, Liu B, Liang C, Liu SB, Ding H, Wang S, Xue T, Song D, Lei Z, Amin HM, Song YH, Zhou J. CLIC4 abrogation promotes epithelial-mesenchymal transition in gastric cancer. Carcinogenesis 41(6):841-849, 2020. e-Pub 2020. PMID: 31560739.
- Amin HM, Morani AC, Daw NC, Lamhamedi-Cherradi SE, Subbiah V, Menegaz BA, Vishwamitra D, Eskandari G, George B, Benjamin RS, Patel S, Song J, Lazar AJ, Wang WL, Kurzrock R, Pappo A, Anderson PM, Schwartz GK, Araujo D, Cuglievan B, Ratan R, McCall D, Mohiuddin S, Livingston JA, Molina ER, Naing A, Ludwig JA. IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma. Cancers (Basel) 12(7):1768, 2020. e-Pub 2020. PMID: 32630797.
- Amin HM, Morani AC, Daw NC, Lamhamedi-Cherradi SE, Subbiah V, Menegaz BA, Vishwamitra D, Eskandari G, George B, Benjamin RS, Patel S, Song J, Lazar AJ, Wang WL, Kurzrock R, Pappo A, Anderson PM, Schwartz GK, Araujo D, Cuglievan B, Ratan R, McCall D, Mohiuddin S, Livingston JA, Molina ER, Naing A, Ludwig JA. IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers. Cancers (Basel) 12(7), 2020. e-Pub 2020. PMID: 32630797.
- Wu C, Ding H, Wang S, Li Y, Liu SB, Wang X, Zheng J, Xue T, Amin HM, Song YH, Zhou J. DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer. Br J Cancer 122(10):1477-1485, 2020. e-Pub 2020. PMID: 32203224.
- Falchook GS, Kurzrock R, Amin HM, Xiong W, Fu S, Piha-Paul SA, Janku F, Eskandari G, Catenacci DV, Klevesath M, Bruns R, Stammberger U, Johne A, Bladt F, Friese-Hamim M, Girard P, El Bawab S, Hong DS. First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors. Clin Cancer Res 26(6):1237-1246, 2020. e-Pub 2020. PMID: 31822497.
- Abdel-Wahab R, Hassan MM, George B, Carmagnani Pestana R, Xiao L, Lacin S, Yalcin S, Shalaby AS, Al-Shamsi HO, Raghav K, Wolff RA, Yao JC, Girard L, Haque A, Duda DG, Dima S, Popescu I, Elghazaly HA, Vauthey JN, Aloia TA, Tzeng CW, Chun YS, Rashid A, Morris JS, Amin HM, Kaseb AO. Impact of Integrating Insulin-Like Growth Factor 1 Levels into Model for End-Stage Liver Disease Score for Survival Prediction in Hepatocellular Carcinoma Patients. Oncology 98(12):836-846, 2020. e-Pub 2020. PMID: 33027788.
- Qayyum A, Hwang KP, Stafford J, Verma A, Maru DM, Sandesh S, Sun J, Pestana RC, Avritscher R, Hassan MM, Amin HM, Rashid A, Wistuba II, Ehman RL, Ma J, Kaseb AO. Immunotherapy response evaluation with magnetic resonance elastography (MRE) in advanced HCC 7(1):329, 2019. e-Pub 2019. PMID: 31779702.
- Kaseb AO, Sanchez NS, Sen S, Kelley RK, Tan B, Bocobo AG, Lim KH, Abdel-Wahab R, Uemura M, Pestana RC, Qiao W, Xiao L, Morris J, Amin HM, Hassan MM, Rashid A, Banks KC, Lanman RB, Talasaz A, Mills-Shaw KR, George B, Haque A, Raghav KPS, Wolff RA, Yao JC, Meric-Bernstam F, Ikeda S, Kurzrock R. Molecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNA. Clin Cancer Res 25(20):6107-6118, 2019. e-Pub 2019. PMID: 31363003.
- George B, George SK, Shi W, Haque A, Shi P, Eskandari G, Axelson M, Larsson O, Kaseb AO, Amin HM. Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma. J Hematol Oncol 12(1):80, 2019. e-Pub 2019. PMID: 31340850.
- Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest 129(8):3324-3338, 2019. e-Pub 2019. PMID: 31305264.
- Bekhit AEA, Duncan A, Bah CSF, Ahmed IAM, Al-Juhaimi FY, Amin HF. Impact of fermentation conditions on the physicochemical properties, fatty acid and cholesterol contents in salted-fermented hoki roe. Food Chem 264:73-80, 2018. e-Pub 2018. PMID: 29853407.
- Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S. Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. Mod Pathol 31(7):1141-1154, 2018. e-Pub 2018. PMID: 29449681.
- Hu L, Zhang X, Wang J, Wang S, Amin HM, Shi P. Involvement of oncogenic tyrosine kinase NPM-ALK in trifluoperazine induced cell cycle arrest and apoptosis in ALK+ anaplastic large cell lymphoma. Hematology 23(5):284-290, 2018. e-Pub 2018. PMID: 29086626.
- Kurt H, Jorgensen JL, Amin HM, Patel KP, Wang SA, Lin P, Kanagal-Shamanna R, Loghavi S, Thakral B, Khogeer HA, Jabbour EJ, Li S, Yin CC, Medeiros LJ, Khoury JD. Chronic Lymphoproliferative Disorder of NK-cells: A Single-Institution Review with Emphasis on Relative Utility of Multimodality Diagnostic Tools. Eur J Haematol 100(5):444-454, 2018. e-Pub 2018. PMID: 29385279.
- Shen C, Song YH, Xie Y, Wang X, Wang Y, Wang C, Liu S, Xue SL, Li Y, Liu B, Tang Z, Chen W, Song J, Amin HM, Zhou J. Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. Oncotarget 8(44):76279-76289, 2017. e-Pub 2017. PMID: 29100311.
- Liu Y, Zhu S, Gu K, Guo Z, Huang X, Wang M, Amin HM, Zhu W, Shi P. GSH-Activated NIR Fluorescent Prodrug for Podophyllotoxin Delivery. ACS Appl Mater Interfaces 9(35):29496-29504, 2017. e-Pub 2017. PMID: 28758393.
- Shen C, Song YH, Xie Y, Wang X, Wang Y, Wang C, Liu S, Xue SL, Li Y, Liu B, Tang Z, Chen W, Song J, Amin HM, Zhou J. Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. Oncotarget. e-Pub 2017. PMID: 28740010.
- Al-Shamsi HO, Abdel-Wahab R, Hassan MM, Shalaby AS, Dahbour I, Lacin S, Mahvash A, Odisio BC, Murthy R, Avritscher R, Abdelsalam ME, Rashid A, Vauthey JN, Aloia TA, Conrad C, Chun YS, Krishnan S, Das P, Koay EJ, Amin HM, Yao JC, Kaseb AO. Natural History of T1N0M0 Hepatocellular Carcinoma: Large-Scale Study in the United States. Oncology. e-Pub 2017. PMID: 28683459.
- Shi W, George SK, George B, Curry CV, Murzabdillaeva A, Alkan S, Amin HM. TrkA is a binding partner of NPM-ALK that promotes the survival of ALK(+) T-cell lymphoma. Mol Oncol. e-Pub 2017. PMID: 28557340.
- Lamhamedi-Cherradi SE, Menegaz BA, Ramamoorthy V, Vishwamitra D, Wang Y, Maywald RL, Buford AS, Fokt I, Skora S, Wang J, Naing A, Lazar AJ, Rohren EM, Daw NC, Subbiah V, Benjamin RS, Ratan R, Priebe W, Mikos AG, Amin HM, Ludwig JA. IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma. J Natl Cancer Inst 108(12), 2016. e-Pub 2016. PMID: 27576731.
- Mohanty A, Sandoval N, Das M, Pillai R, Chen L, Chen RW, Amin HM, Wang M, Marcucci G, Weisenburger DD, Rosen ST, Pham LV, Ngo VN. CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. Oncotarget. e-Pub 2016. PMID: 27713153.
- Vishwamitra D, George SK, Shi P, Kaseb AO, Amin HM. Type I insulin-like growth factor receptor signaling in hematological malignancies. Oncotarget. e-Pub 2016. PMID: 27661006.
- Kaseb AO, Hassan M, Lacin S, Abdel-Wahab R, Amin HM, Shalaby A, Wolff RA, Yao J, Rashid A, Vennapusa B, Feng J, Ohtomo T. Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma. Oncotarget. e-Pub 2016. PMID: 27655712.
- Hu LL, Zhen H, Zhang XN, Zhou L, Amin HM, Shi P. [Effect of Tyrosine Phosphorylation Sites of Oncogenic Protein NPM-ALK on Cell Cycle and Its Related Mechanisms]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 24(4):1201-5, 2016. e-Pub 2016. PMID: 27531800.
- Raghav K, Morris V, Tang C, Morelli P, Amin HM, Chen K, Manyam GC, Broom B, Overman MJ, Shaw K, Meric-Bernstam F, Maru D, Menter D, Ellis LM, Eng C, Hong D, Kopetz S. MET amplification in metastatic colorectal cancer: An acquired response to EGFR inhibition, not a de novo phenomenon. Oncotarget. e-Pub 2016. PMID: 27421137.
- Mitchell J, Tinkey PT, Avritscher R, Van Pelt C, Eskandari G, Konnath George S, Xiao L, Cressman E, Morris JS, Rashid A, Kaseb AO, Amin HM, Uthamanthil R. Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs. Oncology. e-Pub 2016. PMID: 27305144.
- Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S. Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood 126(14):1699-706, 2015. e-Pub 2015. PMID: 26243778.
- Irwin ME, Johnson BP, Manshouri R, Amin HM, Chandra J. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget 6(27):23631-46, 2015. e-Pub 2015. PMID: 26136341.
- Vishwamitra D, Curry CV, Shi P, Alkan S, Amin HM. SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein. Neoplasia 17(9):742-54, 2015. e-Pub 2015. PMID: 26476082.
- Abdel-Wahab R, Shehata S, Hassan MM, Xiao L, Lee JS, Cheung S, Essa HH, Hassabo HM, Shalaby AS, Mosad E, Raghav K, Rashid A, Wolff RA, Morris JS, Amin HM, Kaseb AO. Validation of an IGF-CTP scoring system for assessing hepatic reserve in Egyptian patients with hepatocellular carcinoma. Oncotarget 6(25):21193-207, 2015. e-Pub 2015. PMID: 26098859.
- Yang L, Zhang S, George SK, Teng R, You X, Xu M, Liu H, Sun X, Amin HM, Shi W. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget 6(17):14953-69, 2015. e-Pub 2015. PMID: 25879451.
- Abdel-Wahab R, Shehata S, Hassan MM, Habra MA, Eskandari G, Tinkey PT, Mitchell J, Lee JS, Amin HM, Kaseb AO. Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma. J Hepatocell Carcinoma 2(6):23631-23646, 2015. e-Pub 2015. PMID: 27508202.
- Vishwamitra D, Curry CV, Alkan S, Song YH, Gallick GE, Kaseb AO, Shi P, Amin HM. The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK T-cell lymphoma. Mol Cancer 14:53, 2015. e-Pub 2015. PMID: 25884514.
- Falchook GS, Wheler JJ, Naing A, Jackson EF, Janku F, Hong D, Ng CS, Tannir NM, Lawhorn KN, Huang M, Angelo LS, Vishwamitra D, Hess K, Howard AN, Parkhurst KL, Amin HM, Kurzrock R. Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. Oncotarget 5(21):10280-92, 2014. e-Pub 2014. PMID: 25373733.
- Li J, Kurasawa Y, Wang Y, Clise-Dwyer K, Klumpp SA, Liang H, Tailor RC, Raymond AC, Estrov Z, Brandt SJ, Davis RE, Zweidler-McKay P, Amin HM, Nagarajan L. Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. J Immunol 193(9):4654-62, 2014. e-Pub 2014. PMID: 25238756.
- Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X, Gong Y, Shen H, Yin CC, Jones D, Amin HM, You MJ, Zweidler-McKay P, Ma Y, Kantarjian HM, Arlinghaus RB, Glassman A, Sun X. The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia. Haematologica 99(10):1591-8, 2014. e-Pub 2014. PMID: 24997151.
- Huang Z, Fang Z, Zhen H, Zhou L, Amin HM, Shi P. Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma. Leuk Lymphoma 55(8):1876-83, 2014. e-Pub 2014. PMID: 24206093.
- Ok CY, Wang SA, Amin HM. Leukemic phase of ALK(+) anaplastic large-cell lymphoma, small-cell variant: clinicopathologic pitfalls of a rare entity. Clin Lymphoma Myeloma Leuk 14(4):e123-6, 2014. e-Pub 2014. PMID: 24685107.
- George SK, Vishwamitra D, Manshouri R, Shi P, Amin HM. The ALK inhibitor ASP3026 eradicates NPM-ALK T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget 5(14):5750-63, 2014. e-Pub 2014. PMID: 25026277.
- Hamedani FS, Cinar M, Mo Z, Cervania MA, Amin HM, Alkan S. Crizotinib (PF-2341066) induces apoptosis due to downregulation of pSTAT3 and BCL-2 family proteins in NPM-ALK(+) anaplastic large cell lymphoma. Leuk Res 38(4):503-8, 2014. e-Pub 2014. PMID: 24486291.
- Liu J, Chen G, Feng L, Zhang W, Pelicano H, Wang F, Ogasawara MA, Lu W, Amin HM, Croce CM, Keating MJ, Huang P. Loss of p53 and altered miR15-a/16-1 MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. Leukemia 28(1):118-28, 2014. e-Pub 2014. PMID: 23608884.
- Yue Y, Wang Y, He Y, Yang S, Chen Z, Wang Y, Xing S, Shen C, Amin HM, Wu D, Song YH. Reversal of bortezomib resistance in myelodysplastic syndrome cells by MAPK inhibitors. PLoS One 9(3):e90992, 2014. e-Pub 2014. PMID: 24608798.
- Cinar M, Hamedani F, Mo Z, Cinar B, Amin HM, Alkan S. Bruton tyrosine kinase is commonly overexpressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosis. Leuk Res 37:1271-1277, 2013. e-Pub 2013. PMID: 23962569.
- Shi B, Vishwamitra D, Granda JG, Whitton T, Shi P, Amin HM. Molecular and functional characterizations of the association and interactions between nucleophosmin-anaplastic lymphoma kinase and type I insulin-like growth factor receptor. Neoplasia 15:669-683, 2013. e-Pub 2013. PMID: 23730215.
- Zhu H, Vishwamitra D, Curry CV, Manshouri R, Diao L, Khan A, Amin HM. NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism. J Pathol 230:82-94, 2013. e-Pub 2013. PMID: 23338972.
- Fong EL, Lamhamedi-Cherradi SE, Burdett E, Ramamoorthy V, Lazar AJ, Kasper FK, Farach-Carson MC, Vishwamitra D, Demicco EG, Menegaz BA, Amin HM, Mikos AG, Ludwig JA. Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A 110:6500-6505, 2013. e-Pub 2013. PMID: 23576741.
- Garciarena P, Kamiya-Matsuoka C, Tremont IW, Amin HM, de Groot JF. B lymphoblastic leukemia/lymphoma presenting as seventh cranial nerve palsy. Neurol Clin Pract 3:532-534, 2013. e-Pub 2013.
- Jain P, Verstovsek S, Orlowski R, Yap E, Amin HM. An unusual case of aggressive systemic mastocytosis with associated refractory plasma cell myeloma. Clin Lymphoma Myeloma Leuk 12:459-462, 2012. e-Pub 2012.
- Vishwamitra D, Li Y, Wilson D, Manshouri R, Curry CV, Shi B, Tang XM, Sheehan AM, Wistuba II, Shi P, Amin HM. MicroRNA-96 is a posttranscriptional suppressor of anaplastic lymphoma kinase expression. Am J Pathol 180:1772-1780, 2012. e-Pub 2012.
- Singh MM, Irwin, ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM, Chandra J. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer 118:3433-3445, 2012. e-Pub 2012.
- Vishwamitra D, Shi P, Wilson D, Manshouri R, Vega F, Schlette EJ, Amin HM. Expression and effects of inhibition of IGF-IR tyrosine kinase in mantle cell lymphoma. Haematologica 96:871-880, 2011. e-Pub 2011.
- Janku F, Amin HM, Yang D, Garrido-Laguna I, Trent JC, Kurzrock R. Response of histiocytoses to imatinib mesylate: fire to ashes. J Clin Oncol 28:e633-e636, 2010. e-Pub 2010. PMID: 20733125.
- Quintas-Cardama A, Amin HM, Kantarjian H, Verstovsek S. Treatment of aggressive systemic mastocytosis with daclizumab. Leuk Lymphoma 51:540-542, 2010. e-Pub 2010.
- Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R, Amin HM. Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukemia cells. J Cell Mol Med 14:1777-1792, 2010. e-Pub 2010.
- Singh RR, Kim JE, Davuluri Y, Drakos E, Cho-Vega JH, Amin HM, Vega F. Sonic hedgehog signaling pathway contributes to tumor cell survival and proliferation in diffuse large B-cell lymphoma. Leukemia 24:1025-1036, 2010. e-Pub 2010.
- Wang Y, Klumpp S, Amin HM, Liang H, Estrov Z, Zweidler-McKay P, Brandt S, Agulnick A, Nagarajan L. SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability. Oncogene 29:3044-3053, 2010. e-Pub 2010.
- Bard JD, Gelebart P, Amin HM, Young LC, Ma Y, Lai R. STAT3 is a transcriptional factor regulating the gene expression of SALL4. FASEB J 23:1405-1414, 2009. e-Pub 2009.
- Lakshmikuttyamma A, Takahashi N, Pastural E, Torlakovic E, Amin HM, Garcia-Manero G, Voralia M, Czader M, DeCoteau JF, Geyer CR. RIZ1 is a potential CML tumor suppressor that is down-regulated during disease progression. J Hematol Oncol 2:28-33, 2009. e-Pub 2009.
- Gelebart P, Zak Z, Anand M, Dien-Bard J, Amin HM, Lai R. Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism. Leukemia 23:1836-1846, 2009. e-Pub 2009.
- Dien Bard J, Gelebart P, Anand M, Zak Z, Hegazy SA, Amin HM, Lai R. IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma. Am J Pathol 175:825-834, 2009. e-Pub 2009.
- Shi P, Lai R, Lin Q, Iqbal AS, Young LC, Kwak LW, Ford RJ, Amin HM. IGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cells. Blood 114:360-370, 2009. e-Pub 2009.
- Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood 111:2904-2908, 2008. e-Pub 2008.
- Yu Z, Sun B, Kantarjian HM, Keating MJ, Amin HM, Sun X. Protein expression profiling of cytokines and cytokine receptors on purified chronic lymphocytic leukemia cells from patients with favourable prognostic indicators. Leuk Lymphoma 49:751-756, 2008. e-Pub 2008.
- Inamdar KV, Medeiros LJ, Jorgensen JL, Amin HM, Schlette EJ. Bone marrow involvement by marginal zone B-cell lymphomas of different types. Am J Clin Pathol 129:714-722, 2008. e-Pub 2008.
- Bard JD, Gelebart P, Anand M, Amin HM, Lai R. Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenecity in ALK+ anaplastic large cell lymphoma. Leukemia 22:1595-1603, 2008. e-Pub 2008.
- Gelebart P, Anand M, Armanious H, Peters A, Bard JD, Amin HM, Lai R. Constitutive activation of the Wnt canonical pathway in mantel cell lymphoma. Blood 112:5171-5179, 2008. e-Pub 2008.
- Quintas-Cardama A, Harb AJ, Amin HM, Verstovsek S. Granulocytic sarcoma with massive scalp involvement. Am J Hematol 83:340-342, 2008. e-Pub 2008.
- Ren Y, Medeiros LJ, Amin HM, Rytting ME, Jorgensen JL, Chen W. Unusual expression of CD94 on CD8+ TCR-alpha beta T cells in infectious mononucleosis. Ann Diagn Pathol 11:55-60, 2007. e-Pub 2007. PMID: 17240309.
- Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci USA 104:10494-10499, 2007. e-Pub 2007.
- Amin HM, Hoshino K, Yang H, Lin Q, Lai R, Garcia-Manero G. Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shp1) is associated with progression of chronic myeloid leukaemia. J Pathol 212:402-410, 2007. e-Pub 2007.
- Shi X, Franko B, Frantz C, Amin HM, Lai R. JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Br J Haematol 135:26-32, 2006. e-Pub 2006. PMID: 16939498.
- Rosen DG, Mercado-Uribe I, Yang G, Bast RC, Jr, Amin HM, Lai R, Liu J. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer 107:2730-2740, 2006. e-Pub 2006. PMID: 17063503.
- Qiu L, Lai R, Lin Q, Lau E, Thomazy DM, Calame D, Ford RJ, Kwak LW, Kirken RA, Amin HM. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood 108:2407-2415, 2006. e-Pub 2006. PMID: 16763206.
- Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 108:2726-2735, 2006. e-Pub 2006. PMID: 16763212.
- Lai R, Lefresne SV, Franko B, Hui D, Mirza I, Mansoor A, Amin HM, Ma Y. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome. Mod Pathol 19:1498-1505, 2006. e-Pub 2006. PMID: 16980950.
- Han Y, Amin HM, Frantz C, Franko B, Lee J, Lin Q, Lai R. Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. Leukemia 20:1602-1609, 2006. e-Pub 2006. PMID: 16871283.
- Han Y, Amin HM, Franko B, Frantz C, Shi X, Lai R. Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. Blood 108:2796-2803, 2006. e-Pub 2006. PMID: 16825495.
- Dien J, Amin HM, Chiu N, Wong W, Frantz C, Chiu B, Mackey JR, Lai R. Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. Am J Pathol 169:633-642, 2006. e-Pub 2006. PMID: 16877361.
- Cui W, Kong NR, Ma Y, Amin HM, Lai R, Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol 19:1585-1592, 2006. e-Pub 2006. PMID: 16998462.
- Oyarzo MP, Drakos E, Atwell C, Amin HM, Medeiros LJ, Rassidakis GZ. Intrinsic apoptotic pathway in anaplastic large cell lymphoma. Hum Pathol 37:874-882, 2006. e-Pub 2006. PMID: 16784988.
- Oyarzo MP, Medeiros LJ, Atwell C, Feretzaki M, Leventaki V, Drakos E, Amin HM, Rassidakis GZ. c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma. Blood 107:2544-2547, 2006. e-Pub 2006. PMID: 16304056.
- Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 70:700-713, 2005. e-Pub 2005. PMID: 16023083.
- Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, Claret FX, Medeiros LJ, Amin HM. Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma. Blood 105:827-829, 2005. e-Pub 2005. PMID: 15374880.
- Lai R, Rassidakis GZ, Lin Q, Atwell C, Medeiros LJ, Amin HM. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Hum Pathol 36:939-944, 2005. e-Pub 2005. PMID: 16153455.
- Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, Rassidakis GZ, Zhang W, Fujio Y, Kunisada K, Hamilton SR, Amin HM. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167:969-980, 2005. e-Pub 2005. PMID: 16192633.
- Amin HM, Yang Y, Shen Y, Estey EH, Giles FJ, Pierce SA, Kantarjian HM, O'Brien SM, Jilani I, Albitar M. Having a higher blast percentage in circulation than bone marrow: clinical implications in myelodysplastic syndrome and acute lymphoid and myeloid leukemias. Leukemia 19:1567-1572, 2005. e-Pub 2005. PMID: 16049515.
- Han XY, Lin P, Amin HM, Ferrajoli A. Postsplenectomy cytomegaloviral mononucleosis: marked lymphocytosis, TCRgamma gene rearrangements, and impaired IgM response. Am J Clin Pathol 123:612-617, 2005. e-Pub 2005. PMID: 15743745.
- Cho-Vega JH, Rassidakis GZ, Amin HM, Tsioli P, Spurgers K, Remache YK, Vega F, Goy AH, Gilles F, Medeiros LJ. Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma. Leukemia 18:1872-1878, 2004. e-Pub 2004. PMID: 15385932.
- Cho-Vega JH, Rassidakis GZ, Admirand JH, Oyarzo M, Ramalingam P, Paraguya A, McDonnell TJ, Amin HM, Medeiros LJ. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum Pathol 35:1095-1100, 2004. e-Pub 2004. PMID: 15343511.
- Lai R, Rassidakis GZ, Medeiros LJ, Ramdas L, Goy AH, Cutler C, Fujio Y, Kunisada K, Amin HM, Gilles F. Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Am J Pathol 164:2251-2258, 2004. e-Pub 2004. PMID: 15161657.
- Amin HM, McDonnell TJ, Ma Y, Lin Q, Fujio Y, Kunisada K, Leventaki V, Das P, Rassidakis GZ, Cutler C, Medeiros LJ, Lai R. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 23:5426-5434, 2004. e-Pub 2004. PMID: 15184887.
- Khoury JD, Amin HM, Jorgensen JL, Ostrowski ML, Bloom MG, Medeiros LJ. Composite thymoma and chronic lymphocytic leukemia/small lymphocytic lymphoma involving the anterior mediastinum. Arch Pathol Lab Med 127:E76-E79, 2003. e-Pub 2003. PMID: 12562258.
- Amin HM, Medeiros LJ, Ma Y, Feretzaki M, Das P, Leventaki V, Rassidakis GZ, O'Connor SL, McDonnell TJ, Lai R. Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene 22:5399-5407, 2003. e-Pub 2003. PMID: 12934099.
- Amin HM, Jilani I, Estey EH, Keating MJ, Dey AL, Manshouri T, Kantarjian HM, Estrov Z, Cortes JE, Thomas DA, Giles FJ, Albitar M. Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome. Blood 102:1866-1868, 2003. e-Pub 2003. PMID: 12730116.
- Amin HM, Medeiros LJ, Manning JT, Jones D. Dissolution of the lymphoid follicle is a feature of the HHV8+ variant of plasma cell Castleman's disease. Am J Surg Pathol 27:91-100, 2003. e-Pub 2003. PMID: 12502931.
- Khoury JD, Medeiros LJ, Rassidakis GZ, Yared MA, Tsioli P, Leventaki V, Schmitt-Graeff A, Herling M, Amin HM, Lai R. Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. Clin Cancer Res 9:3692-3699, 2003. e-Pub 2003. PMID: 14506160.
- Amin HM, McDonnell TJ, Medeiros LJ, Rassidakis GZ, Leventaki V, O'Connor SL, Keating MJ, Lai R. Characterization of four mantle cell lymphoma cell lines: establishment of an in vitro study model. Arch Pathol Lab Med 127:424-31, 2003. e-Pub 2003. PMID: 12683869.
- Amin HM, McLaughlin P, Rutherford CJ, Abruzzo LV, Jones D. Cutaneous and systemic plasmacytosis in a patient of Asian descent living in the United States. Am J Dermatopathol 24:241-245, 2002. e-Pub 2002. PMID: 12140441.
- Amin HM, Saeed S, Alkan S. Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). Br J Haematol 115:287-297, 2001. e-Pub 2001. PMID: 11703323.
- Ni H, Ergin M, Huang Q, Qin JZ, Amin HM, Martinez RL, Saeed S, Barton K, Alkan S. Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis. Br J Haematol 115:279-286, 2001. e-Pub 2001. PMID: 11703322.
- Ergin M, Denning MF, Izban KF, Amin HM, Martinez RL, Saeed S, Alkan S. Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein. Exp Hematol 29:1082-1090, 2001. e-Pub 2001. PMID: 11532349.
- Amin HM, Perlman JI, Close TW, Collins SL, Thomas C. Sclerosing orbital pseudotumor with involvement of the optic nerve. Ophthalmic Practice 19:350-355, 2001. e-Pub 2001.
- Amin HM, Petruzzelli GJ, Husain AN, Nickoloff BJ. Primary malignant melanoma of the larynx. Arch Pathol Lab Med 125:271-273, 2001. e-Pub 2001. PMID: 11175650.
- Amin HM, Ahmad S, Walenga JM, Hoppensteadt DA, Leitz H, Fareed J. Soluble P-selectin in human plasma: effect of anticoagulant matrix and its levels in patients with cardiovascular disorders. Clin Appl Thromb Hemost 6:71-76, 2000. e-Pub 2000. PMID: 10775025.
- Amin HM, Ergin M, Denning MF, Quevedo ME, Alkan S. Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia. Br J Haematol 110:552-562, 2000. e-Pub 2000. PMID: 10997964.
- Horn PC, Webster DA, Amin HM, Mascia MF, Werner FW, Fortino MD. The effect of hyperbaric oxygen on medial collateral ligament healing in a rat model. Clin Orthop Relat Res 360:238-242, 1999. e-Pub 1999. PMID: 10101330.
- Amin HM, Candel AG, Husain AN. Pathologic quiz case. A 22-year-old man with an abdominal mass. Arch Pathol Lab Med 123:541-543, 1999. e-Pub 1999. PMID: 10383811.
- Ferrario L, Amin HM, Sugimori K, Camporesi EM, Hakim TS. Site of action of endogenous nitric oxide on pulmonary vasculature in rats. Pflugers Arch 432:523-527, 1996. e-Pub 1996. PMID: 8766013.
- Sugimori K, Amin HM, Esposito BF, Seedat MS, Camporesi EM. Effect of slow versus fast desaturation on the ventilatory response to hypoxia. J Med 27:277-292, 1996. e-Pub 1996. PMID: 9151197.
- Amin HM, Hakim TS, Camporesi EM. Hematological alterations after acute exposure to hyperbaric oxygen in rats. Clin Exp Pharmacol Physiol 22:21-27, 1995. e-Pub 1995. PMID: 7768031.
- Amin HM, Sopchak AM, Esposito BF, Henson LG, Batenhorst RL, Fox AW, Camporesi EM. Naloxone-induced and spontaneous reversal of depressed ventilatory responses to hypoxia during and after continuous infusion of remifentanil or alfentanil. J Pharmacol Exp Ther 274:34-39, 1995. e-Pub 1995. PMID: 7616418.
- Amin HM, Kaniewski WS, Cohen D, Camporesi EM, Hakim TS. Effects of acute exposure to hyperbaric oxygen on the rheology and morphology of the red blood cells in the rat. Microvasc Res 50:417-428, 1995. e-Pub 1995. PMID: 8583954.
- Amin HM, Sopchak AM, Foss JF, Esposito BF, Roizen MF, Camporesi EM. Efficacy of methylnaltrexone versus naloxone for reversal of morphine-induced depression of hypoxic ventilatory response. Anesth Analg 78:701-705, 1994. e-Pub 1994. PMID: 8135389.
- Omran SA, Amin HM, El-Bassiouni NE, Essawy FM, Toiema SM. Vitamin K dependent coagulation proteins in endemic hepatosplenomegaly in Egypt. J Clin Pathol 47:502-504, 1994. e-Pub 1994. PMID: 8063929.
- Amin HM, Omran SA, El-Bassuoni NE, El-Kaliouby AH, El-Ashmawy SA. Assessment of factors II, VII, IX, X, and protein C in hepatosplenic schistosomiasis. Haemostasis 24:22-26, 1994. e-Pub 1994. PMID: 7959352.
- Amin HM, Cigada M, Hakim TS, Camporesi EM. Pulmonary mechanical and vascular responses after acute hyperbaric oxygen exposure. Can J Physiol Pharmacol 71:592-596, 1993. e-Pub 1993. PMID: 8306197.
- Amin HM, Cigada M, Fordyce WE, Camporesi EM. Noninvasive monitoring of respiratory volume. Experimental evaluation of a breath monitoring device. Anaesthesia 48:608-610, 1993. e-Pub 1993. PMID: 8346778.
- Omran SA, Amin HM, El-Bassiouni NE, Essawy FM, Toima SM, El-Kaliouby AH, El-Ashmawy SA. Study of some vitamin K-dependent coagulation proteins in hepatosplenic schistosomiasis. Egypt J Haematol 18:39-48, 1993. e-Pub 1993.
- Vishwamitra D, George SK, Curry CV, Creighton CJ, Shi P, Song YH, Gilcrease MZ, Rashid A, Alkan S, Kaseb AO, Amin HM. MicroRNA-30 family attenuates tumorigenesis through posttranslational downregulation of IGF-IR. Proc Natl Acad Sci USA.
- Liu Y, Zhu S, Gu K, Guo Z, Huang X, Wang M, Amin HM, Zhu W, Shi P. GSH-activated NIR fluorescent theranostic prodrug for podophyllotoxin delivery. Small.
- Vishwamitra D, Shi P, Amin HM. Role of the insulin-like growth factor signaling system in hematological malignancies. Br J Haematol.
- Aladily TN, Ng D, Handy B, Jorgensen JL, Milton DR, Yin CC, Sargent R, Miranda R, Young KH, Amin HM, You MJ, Schlette E, Hoehn D, Liang CS, Tian T, Wang X, Lin P. Assessing minimal residual disease in plasma cell myeloma: a comparison between multicolor flow cytometry, immunohistochemistry, and immunofixation electrophoresis. Am J Clin Pathol.
- Falchook GS, Wheler JJ, Naing A, Jackson EF, Hong D, Ng CC, Tannir NM, Lawhorn KN, Vishwamitra D, Howard AN, Amin HM, Kurzrock R. Anti-angiogenic therapy and upregulation of HIF-1 enhanced by proteasome inhibition: a phase I trial of bevacizumab in combination with bortezomib in patients with advanced malignancies. Clin Cancer Res.
Invited Articles
- Shi P, Amin HM. JAK3 (Janus Kinase 3 or Just Another Kinase 3). Atlas Genet Cytogenet Oncol Haematol:http://atlasgeneticsoncology.org/Genes/JAK3ID41032ch19p13.html, 2007. e-Pub 2007.
- Amin HM, Lai R. Pathobiology of ALK+ anaplastic large-cell lymphoma. Blood 110(2259-2267), 2007. e-Pub 2007.
Review Articles
- Gok Yavuz, B, Datar, S, Chamseddine, SM, Mohamed, Y, Lapelusa, M, Lee, SS, Hu, Z, Koay, EJ, Tran Cao, HS, Jalal, P, Daniel-MacDougall, CR, Hassan, MM, Duda, DG, Amin, H, Kaseb, A. The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma. Cancers 15(19), 2023. e-Pub 2023. PMID: 37835569.
- Yavuz BG, Pestana RC, Abugabal YI, Krishnan S, Chen J, Hassan MM, Wolff RA, Rashid A, Amin HM, Kaseb AO. Origin and role of hepatic myofibroblasts in hepatocellular carcinoma. Oncotarget 11(13):1186-1201, 2020. e-Pub 2020. PMID: 32284794.
- Lamhamedi-Cherradi SE, Santoro M, Ramammoorthy V, Menegaz BA, Bartholomeusz G, Iles LR, Amin HM, Livingston JA, Mikos AG, Ludwig JA. 3D tissue-engineered model of Ewing's sarcoma. Adv Drug Deliv Rev 79-80C:155-171, 2014. e-Pub 2014. PMID: 25109853.
Other Articles
- George, B, Konnath George, S, Shi, W, Haque, MA, Shi, P, Eskandari, G, Axelson, M, Larsson, O, Kaseb, A, Amin, H Correction. Journal of Hematology and Oncology 16(1), 2023. PMID: 37312210.
Abstracts
- Amin HM, Haque A, Sahu V, Lombardo JL, Xiao L, George B, Wolff RA, Morris JS, Rashid A, Kopchick JJ, Kaseb AO. Disruption of growth hormone receptor gene expression abrogates hepatocellular carcinoma development and progression. Growth Hormone (GH)/Prolactin (PRL) Family in Biology and Disease Conference, Federation of American Societies for Experimental Biology (FASEB), Summer Research Conferences (SRC), 2022. e-Pub 2022.
- Kaseb AO, Duda DG, Cao HST, Abugabal YI, Vence LM, Rashid A, Pestana R, Blando JM, Singh S, Vauthey JN, Hassan M, Amin HM, Qayyum A, Chun YS, Tzeng CWD, Sakamuri D, Wolff RA, Yao JC, Allison JP, Sharma P. Randomized, open-label, preoperative phase II study evaluating nivolumab alone or nivolumab plus ipilimumab in patients with resectable HCC 38 (Supplement):486, 2020. e-Pub 2020.
- Amin HM, Haque A, George B, Hassan M, Rashid A, Morris JS, Wolff RA, Kaseb AO. Blockade of growth hormone receptor signaling as an effective strategy to eradicate hepatocellular carcinoma. Growth Hormone (GH)/Prolactin (PRL) Family in Biology and Disease Conference, Federation of American Societies for Experimental Biology (FASEB), Summer Research Conferences (SRC), 2019. e-Pub 2019.
- Abdelhakeem A, Kaseb AO, Hatia R, Abdel-Wahab R, Amin HM, Hassan M. Distribution of insulin-like growth factor-1 (IGF-1) binding proteins in hepatocellular carcinoma with a without cirrhosis 37 (Supplement):193, 2019. e-Pub 2019.
- Abugabal YI, Hassan M, Xiao L, Morris J, Pestana RC, Abdel-Wahab R, Hatia R, Chang P, Girard L, Rashid A, George B, Raghav KPS, Abdelhakeem A, Wolff RA, Amin HM, Kaseb AO. IGF-Child-Pugh score as a predictor of treatment outcome in Child-Pugh A, advanced hepatocellular carcinoma patients undergoing sorafenib therapy 37 (Supplement):223, 2019. e-Pub 2019.
- Pestana RC, Hassan M, Abdel-Wahab R, Abugabal YI, Girard L, Hatia R, Nguyen V, Raghav KPS, Morris J, Rashid A, Wolff RA, Amin HM, Kaseb AO. Plasma GH as a diagnostic and prognostic biomarker in HCC without cirrhosis 37 (Supplement):227, 2019. e-Pub 2019.
- Pestana RC, Abugabal YI, Xiao L, Hassan M, Abdel-Wahab R, Girard L, Raghav KPS, Morris J, Rashid A, Qayyum A, Meric-Bernstam, Wolff RA, Yao JC, Amin HM, Kaseb AO. Molecular profiling by circulating DNA (ctCNA) and benefit from anti-PD-1 in HCC 37 (Supplement):e15679, 2019. e-Pub 2019.
- Kaseb AO, Zohner E, Xiao L, Wang Z, Hassan M, Abdel-Wahab R, Ballard K, Wolff RA, Amin HM, Wang W, Yao JC, Morris J. Global protein score (GloPAS): a comprehensive risk score to predict hepatocellular carcinoma biology and estimate patients’ survival. ASCO GI Cancer Symposium 36(4), 2018. e-Pub 2018.
- Kaseb AO, Zohner E, Xiao L, Wang Z, Hassan M, Abdel-Wahab, Ballard K, Wolff RA, Amin HM, Wang W, Yao JC, Morris J. Global protein score (GloPAS): a comprehensive risk score to predict hepatocellular carcinoma and estimate patients' survival 36 (Supplement):287, 2018. e-Pub 2018.
- Kaseb AO, Abdel-Wahab R, Hassan M, Xiao L, Raghav KPS, Girard L, Amin HM, Morris J, Wolff RA, Yao JC. A prospective biomarker study to assess IGF-1 score ability to sub-stratify Chile-Turcotte-Pugh classes and predict response to systemic therapy in hepatocellular carcinoma 35(Supplement):e15662, 2017. e-Pub 2017.
- HHassan M, Abdel-Wahab R, Wolff RA, Botrus G, Shalaby A, Li D, Torres HA, Morris JS, Ballard K, Hawk E, Shalaby A, Amin HM, Yao JC, Lenzi R, Joss JA, Jalal PK, Khaderi S, Lacin S, Kaseb AO. Growth hormone and hepatocellular carcinoma. The Liver Meeting, AASLD. The Liver Meeting, AASLD, 2016. e-Pub 2016.
- Lacin S, Abdel-Wahab R, Hassan M, Shalaby AS, Amin HM, Wolff RA, Yao JC, Mistry A, Feng JD, Ohtomo T, Kaseb AO. Evaluating clinical and prognostic implications of Glypican 3 in hepatocellular carcinoma. ASCO, 2016. e-Pub 2016.
- Abdel-Wahab R, Lacin S, Shalaby AS, Hassan M, Xiao L, Morris J, Amin HM, Kaseb AO. Integrating insulin-like growth factor-1 (IGF-1) score into Barcelona Clinic Liver Cancer and Cancer of the Liver Italian Group (CLIP) scores. ASCO, 2016. e-Pub 2016.
- Abdel-Wahab R, Lacin S, Shalaby AS, Hassan M, Xiao L, Morris J, Amin HM, Kaseb AO. Impact of integrating insulin-like growth factor-1 (IGF-1) in model for end stage liver disease (MELD) scores on predicting hepatocellular carcinoma patients’ survival. ASCO, 2016. e-Pub 2016.
- Irwin ME, Manshouri R, Johnson B, Amin HM, Chandra J. Targeting Egr-1 is an effective strategy for overcoming kinase inhibitor resistance in CML. Cancer Res, 2016. e-Pub 2016.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Janku F, Granda JG, Zheng H, Klevesath MB, Kohler K, Bladt F, Johne A, Kurzrock R. MSC2156119J (EMD 1214063), an oral selective c-Met inhibitor, in patients with advanced solid tumors: results of the first-in-human phase I trial. Cancer Res, 2016. e-Pub 2016.
- Hassan M, Abdel-Wahab R, Kaseb AO, Shalaby A, Botrus G, Lacin S, Morris JS, Amin HM, Wolff RA, Hwang JP, Li D, Torres HA, Shalaby A, Lenzi R, Yao JC, Joss JA, Jalal PK, Khaderi S, Ballard K, Hawk E. Hepatocellular carcinoma screening in high-risk populations in the United States. The Liver Meeting, AASLD, 2016. e-Pub 2016.
- Hassan M, Abdel-Wahab R, Kaseb AO, Shalaby A, Botrus G, Lacin S, Morris JS, Amin HM, Wolff RA, Hwang JP, Li D, Torres HA, Lenzi R, Yao JC, Joss JA, Jalal PK, Khanderi S, Ballard K, Hawk E. Hepatocellular carcinoma screening in high-risk populations in the United States 64(Supplement A):674-675, 2016. e-Pub 2016.
- Falchook GS, Kurzrock R, Amin HM, Fu S, Piha-Paul SA, Janku F, Zheng HX, Sarholz B, Johne A, Hong DS. Efficacy, safety, biomarkers and phase II dose modeling in a phase I trial of the oral selective c-Met inhibitor tepotinib (MSC2156119J). J Clin Oncol, 2015. e-Pub 2015.
- Raghav KPS, Tang C, Morelli P, Amin HM, Chen K, Manyam GC, Broom BM, Talasaz AA, Overman MJ, Shaw KR, Meric-Bernstam F, Maru DM, Eng C, Hong DS, Kopetz S. Multiple independent methods fail to confirm MET amplification rate reported in literature for metastatic colorectal cancer (mCRC). J Clin Oncol, 2015. e-Pub 2015.
- Abdel-Wahab R, Eid SM, Hassan M, Xiao L, Lee JS, Cheung SH, Hassabo HM, Shalaby AS, Essa HH, Mossad E, Raghav KS, Rashid A, Wolff RA, Morris J, Amin HM, Kaseb AO. International validation of an IGF-PCT scoring system for assessing hepatic reserve in hepatocellular carcinoma. J Clin Oncol, 2015. e-Pub 2015. PMID: 26098859.
- Bladt F, Jaehrling F, Friese-Hamim M, Falchook GS, Amin HM, Klevesath MB, Blaukat A. Development of a sensitive assay for measuring pharmacodynamic modulation of C-et in biopsies. 105th American Association for Cancer Research (AACR) Annual Meeting, 2014. e-Pub 2014.
- Irwin ME, Manshouri R, Johnson B, Amin HM, Chandra J. Targeting Egr-1 is an effective strategy for overcoming kinase inhibitor resistance in CML. 105th American Association for Cancer Research (AACR) Annual Meeting, 2014. e-Pub 2014.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Janku F, Granda JG, Zheng H, Klevesath MB, Kohler K, Bladt F, Johne A, Kurzrock R. MSC2156119J (EMD 1214063), an oral selective c-Met inhibitor, in patients with advanced solid tumors: results of the first-in-human phase I trial. AACR Annual Meeting 2014, 2014. e-Pub 2014.
- Vishwamitra D, Curry CV, Alkan S, Shi P, Amin HM. SUMOylation sustains the stability of NPM-ALK oncogenic protein and facilitates its nuclear accumulation in T-cell anaplastic large-cell lymphoma. 56th ASH Annual Meeting and Exposition Abstracts and Program, 2014. e-Pub 2014.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Janku F, Granda JG, Zheng H, Klevesath MB, Kohler K, Bladt F, Johne A, Kurzrock R. Results of the first-in-human phase I trial assessing the oral selective c-Met inhibitor MSC2156119J (EMD 1214063) in patients with advanced solid tumors. The 52nd Annual Meeting of Japanese Society of Clinical Oncology, 2014. e-Pub 2014.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Janku F, Granda JG, Zheng H, Klevesath MB, Kohler K, Bladt F, Johne A, Kurzrock R. Results of the first-in-human phase I trial assessing MSC2156119J (EMD 1214063), an oral selective c-Met inhibitor, in patients (pts) with advanced solid tumors. J Clin Oncol, 2014. e-Pub 2014.
- Bladt F, Jaehrling F, Friese-Hamim M, Falchook GS, Amin HM, Klevesath MB, Blaukat A. Development of a sensitive assay for measuring pharmacodynamic modulation of c-Met in biopsies. AACR Annual Meeting 2014, 2014. e-Pub 2014.
- Irwin ME, Manshouri R, Johnson B, Amin HM, Chandra J. Targeting Egr-1 is an effective strategy for overcoming kinase inhibitor resistance in CML. AACR Annual Meeting 2014, 2014. e-Pub 2014.
- Shi W, George SK, Curry CV, Alkan S, Amin HM. TrkA, a novel binding partner of NPM-ALK oncogenic tyrosine kinase, facilitates the survival of T-cell anaplastic large-cell lymphoma. 56th ASH Annual Meeting and Exposition Abstracts and Program, 2014. e-Pub 2014.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Janku F, Zheng H, Bladt F, Johne A, Kurzrock R. First-in-human phase I trail assessing the highly selective c-Met inhibitor MSC2156119J (EMD 1214063) in patients with advanced solid tumors. European Society for Medical Oncology Congress, 2014. e-Pub 2014.
- Vishwamitra D, Curry CV, Alkan S, Shi P, Amin HM. Decreased levels of the transcription factors Ik-1 and MZF1 contribute to upregulation of IGF-IR expression in NPM-ALK+ T-cell anaplastic large-cell lymphoma. 2nd American Association for Cancer Research (AACR) Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies, 2014. e-Pub 2014.
- Yang L, Zhang S, Liu H, Amin HM, Shi W. Combined targeting of Notch1 and proteasome as an effective strategy to suppress T-cell leukemia/lymphoma. Proceedings of The American Association for Cancer Research Conference on Hematologic Malignancies: Translating Discoveries To Novel Therapeutics, 2014. e-Pub 2014.
- Vishwamitra D, George SK, Manshouri R, Shi P, Amin HM. In vitro and in vivo anti-tumor activity of the selective ALK inhibitor ASP3026 against NPM-ALK+ T-cell anaplastic large-cell lymphoma. American Association for Cancer Research (AACR) Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery Into Improved Outcomes:87, 2013. e-Pub 2013.
- Hamedani FS, Mo Z, Amin HM, Cervania M, Alkan S. Crizotinib, a novel inhibitor of ALK, induces apoptosis and downregulation of pSTAT3 in ALK+ anaplastic large cell lymphoma. United States and Canadian Academy of Pathology 102nd Annual Meeting Program Book, 2013. e-Pub 2013.
- Cinar M, Hamedani FS, Mo Z, Cinar B, Amin HM, Alkan S. Bruton tyrosine kinase is commonly expressed in mantle cell lymphoma and its attenuation by Ibrutnib induces apoptosis of mantle cell lymphoma cells. United States and Canadian Academy of Pathology 102nd Annual Meeting Program Book:177, 2013. e-Pub 2013.
- Fong ELS, S-E L, Burdett E, Ramamoorthy V, Lazar AJ, Kasper FK, Farach-Carson MC, Vishwamitra D, Demicco EG, Menegaz B, Amin HM, Ludwig JA, Mikos AG. Engineering a three-dimensional in vitro model of bone sarcoma for drug-testing. Society for Biomaterials Annual Meeting and Exposition Final Program:48, 2013. e-Pub 2013.
- Falchook GS, Hong D, Amin HM, Fu S, Piha-Paul SA, Janku F, Subbiah V, Naing A, Wheler JJ, Klevesath MB, Kohler K, Johne A, Bladt F, Kurzrock R. Phase I study of oral selective c-Met inhibitor EMD 1214063 in patients with advanced solid tumors. J Clin Oncol 31(Suppl.):2506, 2013. e-Pub 2013.
- Raymond A, Liang H, Liang S, Lu Y, Davis RE, Amin HM, Nagarajan L. c-REL is a transcriptional target of homeobox gene mesoderm inducer in Xenopus Like 1 (MIXL1). Keystone Symposia: Myeloid cells: regulation and inflammation:72, 2013. e-Pub 2013.
- Raghav KPS, Amin HM, Wang W, Manyam GC, Broom BM, Eng C, Overman MJ, Kopetz S. MET overexpression as a hallmark for epithelial-mesenchymal transition (EMT) phenotype in colorectal cancer. J Clin Oncol 31(Suppl.):3529, 2013. e-Pub 2013.
- Ng DP, Liang CS, Tian T, Yin C, Young KH, Jorgensen JL, Hoehn D, Sargent R, Miranda RN, Amin HM, You J, Schlette E, Lin P. Assessing minimal disease in plasma cell neoplasms: a comparison between multicolor flow cytometry and immunohistochemistry. Mod Pathol 25:357A, 2012. e-Pub 2012.
- Amin HM, Falchook GS, Fu S, Hong DS, Tsimberidou AM, Naing A, Wheler JJ, Piha-Paul SA, Janku F, Klevesath MB, Jego V, Johne A, Kurzrock R. First-in-human phase I dose-escalation study of the oral selective c-Met inhibitor EMD 1204831 in patients with advanced solid tumors. J Clin Oncol 30(Suppl.):3107, 2012. e-Pub 2012.
- Falchook GS, Hong DS, Amin HM, Fu S, Piha-Paul SA, Klevesath MB, Jego V, Johne A, Stinchi S, Kurzrock R. Phase I dose-escalation study of oral selective c-Met inhibitor EMD 1214063 in patients with advanced solid tumors. Ann Oncol 23:444PD, 2012. e-Pub 2012.
- Falchook GS, Naing A, Fu S, Amin HM, Piha-Paul SA, Hong DS, Tsimberidou AM, Wheler JJ, Janku F, Klevesath MB, Jego V, Johne A, Kurzrock R. A phase I dose-escalation study of EMD 1214063, an oral selective cMet inhibitor, in patients with advanced solid tumors. Japanese Society of Medical Oncology Book of Abstracts:ISA-1, 2012. e-Pub 2012.
- Ng DP, Liang CS, Tian T, Yin C, Young KH, Jorgensen JL, Hoehn D, Sargent R, Miranda RN, Amin HM, You MJ, Schlette E, Lin P. Assessing minimal disease in plasma cell neoplasms: a comparison between multicolor flow cytometry and immunohistochemistry 25:357A, 2012. e-Pub 2012.
- Amin HM, Falchook GS, Fu S, Hong DS, Tsimberidou AM, Naing A, Wheler JJ, Piha-Paul SA, Janku F, Klevesath MB, Jego V, Johne A, Kurzrock R. First in-human phase I dose escalation study of the oral selective c-Met inhibitor EMD 1204831 in patients with advanced solid tumors 30((Supplement: 3107)), 2012. e-Pub 2012.
- Zhu H, Amin HM. MPM-ALK oncogene upregulates the expression of inducible nitric oxide synthase in T-cell lymphoma through a STAT3/microRNA-26a-dependent mechanism. Blood 118:1383, 2011. e-Pub 2011.
- Li J, Klumpp S, Amin HM, Liang H, Brandt SJ, Nagarajan L. Sequence specific single stranded DNA binding protein (SSBP2) is a regulator of hematopoietic stem cell function. Blood 118:1384, 2011. e-Pub 2011.
- Vishwamitra D, Shi P, Amin HM. MicroRNA-30 family functions as a tumor suppressor by inducing posttranscriptional downregulation of IGF-IR expression. Keystone Symposia: MicroRNAs and non-coding RNAs and cancer:228, 2011. e-Pub 2011.
- Li Y, Shi P, Amin HM. MicroRNA-96 is a posttranscriptional suppressor of anaplastic lymphoma kinase expression in human cancer. American Association for Cancer Research (AACR) 102nd Annual Meeting:3996, 2011. e-Pub 2011.
- Li J, Klumpp S, Amin HM, Liang H, Brandt S, Nagarajan L. Sequence specific single stranded DNA binding protein (SSBP2) is a regulator of hematopoietic stem cell activity 118:606, 2011. e-Pub 2011.
- Falchook GS, Fu S, Amin HM, Tsimberidou AM, Hong DS, Naing A, Klevesath MB, Mattiacci MR, Johne A, Kurzrock R. Phase I dose-escalation study of the oral selective c-Met inhibitor EMD 1204831 in patients with advanced solid tumours. Eur J Cancer 47:S158, 2011. e-Pub 2011.
- Falchook GS, Fu S, Amin HM, Piha-Paul SA, Hong DS, Naing A, Klevesath MB, Mattiacci MR, Di Cara A, Kurzrock R. A phase I dose-escalation study of EMD 1214063, an oral selective c-Met inhibitor, in patients with advanced solid tumours. Eur J Cancer 47((Supplement 1): S158), 2011. e-Pub 2011.
- Zhu H, Amin HM. NPM-ALK oncogene upregulates the expression of inducible nitric oxide synthase in T-cell lymphoma through a STAT3/microRNA-26a-dependent mechanism 118:605, 2011. e-Pub 2011.
- Vishwamitra D, Wilson D, Shi P, Amin HM. MicroRNA-30 family functions as a tumor suppressor by inducing posttranscriptional downregulation of IGF-IR expression. Innovations in Cancer Prevention and Research Conference, Cancer Prevention and Research Institute of Texas (CPRIT), 2011. e-Pub 2011.
- Falchook GS, Fu S, Amin HM, Tsimberidou AM, Hong DS, Naing A, Klevesath MB, Mattiacci M, Johne A, Kurzrock R. Phase I dose-escalation study of the oral selective c-Met inhibitor EMD 1204831 in patients with advanced solid tumours 47 (Supplement 1)(S158), 2011. e-Pub 2011.
- Vishwamitra D, Wilson D, Manshouri R, Shi P, Amin HM. IGF-IR tyrosine kinase as a novel molecular target to eradicate mantle cell lymphoma S131, 2011. e-Pub 2011.
- Vishwamitra D, Shi P, Amin HM. MicroRNA-30 family functions as a tumor suppressor by inducing posttranscriptional downregulation of IGF-IR expression. Keystone Symposia: MicroRNAs and human disease, UTHealth Graduate School of Biomedical Sciences, 2011. e-Pub 2011.
- Naing A, LoRusso P, Gupta S, Benjamin RS, Rohren E, Chen HX, Doyle L, Berry DA, Amin HM, Kurzrock R. Dual inhibition of IGFR and mTOR pathways. J Clin Oncol 28:7s, 2010. e-Pub 2010.
- Vishwamitra D, Manshouri R, Wilson D, Shi P, Amin HM. Expression and effects of inhibition of IGF-IR tyrosine kinase in mantle cell lymphoma. Keystone Symposia: New paradigms in cancer therapeutics:84, 2010. e-Pub 2010.
- Amin HM. NPM-ALK+ T-cell lymphoma as a model for developing cancer therapeutics. 2nd International Conference on Drug Discovery and & Therapy Book of Abstracts:9, 2010. e-Pub 2010.
- Amin HM. NPM-ALK+ T-cell lymphoma as a model for developing cancer therapeutics. 2nd International Conference on Drug Discovery and Therapy (ICDDT), 2010. e-Pub 2010.
- Vishwamitra D, Manshouri R, Wilson D, Shi P, Amin HM. Expressions and effects of inhibition of IGF-IR tyrosine kinase in mantle cell lymphoma. Keystone Symposia: New paradigms in cancer therapeutics, UTHealth Graduate School of Biomedical Sciences, 2010. e-Pub 2010.
- Naing A, Kurzrock R, Chen H, Hong DS, Falchook G, Doyle L, Lawhorn K, Burger AM, Ng C, Amin HM, LoRusso PM. Multicenter phase I clinical trial of an insulin like growth factor (IGF-R) inhibitor (IMC-A12) in combination with a mammalian target of rapamycin (mTOR) inhibitor (CCI-779) to overcome resistance to mTOR inhibition. Mol Cancer Ther 8:B61, 2009. e-Pub 2009.
- Sun B, Mallampati S, Gong Y, Wang D, You MJ, Amin HM, Ma Y, Rajewsky K, Lefebvre V, Sun X. Conditional knockout of Sox4 markedly affects B lymphopoiesis in adult mice. Blood 114:994, 2009. e-Pub 2009.
- Mattiuzzi G, Amin HM, Kantarjian H, Garcia-Manero G, Cortes J. Baseline serum ferritin predicts rate of infection in patients with acute myelogenous leukemia and high-risk myelodysplastic syndrome. Blood 114:644, 2009. e-Pub 2009.
- Falchook GS, Wheeler JJ, Tannir NM, Naing A, Jackson E, Hong D, Lawhorn KN, Ng C, Amin HM, Kurzrock R. Hypoxia-inducible facror 1α (HIF-1α) modulation in combination with anti-angiogenic therapy. J Clin Oncol 27:159s, 2009. e-Pub 2009.
- Sun B, Mallampati S, Gong Y, Wang D, You MJ, Amin HM, Ma Y, Bajewsky K, Lefebvre V, Sun X. Conditional knock-out of Sox4 markedly affects B lymphopoiesis in adult mice 114:2524, 2009. e-Pub 2009.
- Konoplev S, Nguyen M, Huang X, Rassidakis GZ, Garcia-Manero G, Yin CC, Amin HM, Schlette E, Lin P, Vega-Vazquez F, Admirand J, Huh Y, You J, Jorgensen JL, Kantarjian HM, Medeiros LJ, Bueso-Ramos C. Cytoplasmic expression of nucleophosmin does not predict favorable prognosis in AML patients. Mod Pathol 21:260A, 2008. e-Pub 2008.
- Mallampati S, Sun B, Gong Y, Wang E, You MJ, Amin HM, Ma Y, Shen H, Zweidler-McKay P, Jones D, Yin C, Glassman A, Kantarjian HM, Arlinghaus RB, Sun X. Rooting into the soil, a model for the role of Sox4 in leukemia. Blood 112:1298, 2008. e-Pub 2008.
- Shi P, Lai R, Gergely M, Arlinghaus RB, Amin HM. Expression and biological significance of type I insulin-like growth factor receptor tyrosine kinase in chronic myeloid leukemia. AACR 99th Annual Meeting, 2008. e-Pub 2008.
- Mallampati S, Sun B, Gong Y, Wang E, You MJ, Amin HM, Ma Y, Shen H, Zweidler-McKay P, Jones D, Yin C, Glassman A, Kantarjian HM, Arlinghaus RB, Sun X. Rooting into the soil, a model for the role of Sox4 in leukemia 112:3794, 2008. e-Pub 2008.
- Konoplev S, Nguyen M, Huang X, Rassidakis GZ, Garcia-Manero G, Yin CC, Amin HM, Schlette E, Lin P, Vega-Vasquez F, Admirand J, Huh Y, You J, Jorgensen JL, Kantarjian HM, Medeiros LJ, Bueso-Ramos C. Cytoplasmic expression of nucleophosmin does not predict favorable prognosis in AML patients 21:260A, 2008. e-Pub 2008.
- Amin HM, Inamdar KV, Medeiros LJ, Schlette EJ. Intrasinusoidal infiltration is more frequent in splenic marginal zone lymphoma, but lymphoid follicle formation is common in all types of marginal zone lymphoma. Mod Pathol 20:233A, 2007. e-Pub 2007.
- Shi P, Lin Q, Iqbal AS, Lai R, Amin HM. Functional interactions between IGF-IR tyrosine kinase and NPM-ALK oncogene identify IGF-IR signaling as a therapeutic target in T-cell ALK-positive anaplastic large-cell lymphoma. Making Connections: A Canadian Cancer Research Conference Celebrating NCIC’s 60th Anniversary Book of Abstracts:206-207, 2007. e-Pub 2007.
- Ma Y, Yang J, Kong N, Amin HM, Chai L. The expression of SALL4, a newly identified stem cell factor, is correlated with chronic myeloid leukemia disease progression. Blood 110:857A, 2007. e-Pub 2007.
- Yu Z, Sun B, Kantarjian HM, Amin HM, Sun X. Protein expression profiling of cytokines/cytokine receptors on purified chronic lymphocytic leukemia cells. Blood 110:251B, 2007. e-Pub 2007.
- Shi P, Lin Q, Iqbal AS, Kwak LW, Lai R, Amin HM. Functional synergism between IGF-IR tyrosine kinase and NPM-ALK oncogene identifies a novel role of IGF-IR in malignant lymphoma. Mol Cancer Ther 6:3555S, 2007. e-Pub 2007.
- Amin HM, Inamdar KV, Medeiros LJ, Schlette EJ. Intrasinusoidal infiltration is more frequent in splenic marginal zone lymphoma, but lymphoid follicle formation is common in all types of marginal zone lymphoma 20:233A, 2007. e-Pub 2007.
- Ma Y, Yang J, Chai L, Liu F, Amin HM. Bmi-1 is a SALL4 target gene in hematopoietic and leukemic cells. Blood 108:410A, 2006. e-Pub 2006.
- Ma Y, Barnett T, Chai L, Yang J, Alipio Z, Lin P, Amin HM, Fink L, Di C, Yan H, Ward D. DEAH-Box splicing factor gene, Prp16 amplification in acute myeloid leukemia. Blood 108:198B, 2006. e-Pub 2006.
- Chandra J, Amin HM, Howard A, Miller CP, Lin Q, Ban K. Fyn upregulation is a novel ROS-dependent mechanism controlling CML growth, progression and imatinib resistance. Blood 108:635A, 2006. e-Pub 2006.
- Takahashi N, Pastural E, Lowsky R, Torlakovic E, Czader M, Garica-Manero G, Amin HM, Geyer CR, DeCoteau J. RIZ1 is donwnregulated during CML progression and displays tumor suppressor properties in CML cell lines. Blood 108:605A, 2006. e-Pub 2006.
- Schlette E, Amin HM, Medeiros LJ. Intrasinusoidal pattern of BM involvement in splenic marginal zone lymphoma is infrequent and focal. XIII. Meeting for the European Association for Haematopathology Book of Abstracts:19, 2006. e-Pub 2006.
- Schlette E, Amin HM, Medeiros LJ. CD21 and CD23 immunohistochemical staining highlights lymphoid follicles in splenic marginal zone lymphomas involving bone marrow. XIII. Meeting for the European Association for Haematopathology Book of Abstracts:18, 2006. e-Pub 2006.
- Lai R, Lefresne SV, Franko BC, Shi X, Hui D, Mirza I, Mansoor A, Amin HM, Ma Y. Somatic hypermutation of the immunoglobulin heavy chain (IgH) gene in mantle cell lymphoma. Mod Pathol 19:235A, 2006. e-Pub 2006.
- Schlette E, Amin HM, Medeiros LJ. CD21 and CD23 immunohistochemical staining highlights lymphoid follicles in splenic marginal zone lymphomas involving bone marrow. EA4HP 2006, 2006. e-Pub 2006.
- Amin HM, Qiu L, Lin Q, Kirken RA, Lai R. Autocrine release of interleukin-9 promotes Janus kinase 3-dependent survival of anaplastic lymphoma kinase-positive T/null lymphoma cells. J Immunol 176:S32, 2006. e-Pub 2006.
- Sun X, Wang E, Jones DM, Shen H, Johnson MM, Issa J-P J, Amin HM, Ginsberg CF, Kantarjian HM, Andreeff M, Kornblau SM, Glassman AB, Arlinghaus RB. SOX4 gene expression in human leukemic and benign hematopoietic cells. Proceedings of the American Association for Cancer Research 97th Annual Meeting:3035, 2006. e-Pub 2006.
- Ma Y, Barnett T, Chi L, Yang J, Alipio Z, Lin P, Amin HM, Fink L, Di C, Yan H, Ward D. DEAH-box splicing factor gene, prp16 amplification in acute myeloid leukemia 108:4479, 2006. e-Pub 2006.
- Lai R, Rodriguez-Galindo C, Navid F, Fuller CE, Amin HM, Dalton J, Jenkins JJ, Khoury JD. STAT3 activation in Ewing sarcoma family of tumors. Mod Pathol 18:17A, 2005. e-Pub 2005.
- Rosen D, Amin HM, Bast RC, Lai R, Liu J. Clinical significance of pSTAT3 expression in ovarian carcinoma. Mod Pathol 18:201A, 2005. e-Pub 2005.
- Lin Q, Prudkin ML, Kantarjian HM, Cortes JE, Lau E, Grammatikakis I, Thomazy VA, Lai R, Amin HM. Role of Jak3 in chronic myeloid leukemia: evidence to identify Jak3 as a potential therapeutic target. Blood 106:804A-805A, 2005. e-Pub 2005.
- Chai L, Cui W, Yang J, Di C, Amin HM, Ma Y. SALL4, a novel oncogene induces myelodysplastic syndrome and acute leukemia via Wnt/β-catenin pathway. Blood 106:397A, 2005. e-Pub 2005.
- Amin HM, McDonnell TJ, Ma Y, Lin Q, Fujio Y, Kunisada K, Leventaki V, Das P, Rassidakis GZ, Medeiros LJ, Lai R. Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Keystone Symposia: Jaks and Stats: Development to disease:74, 2004. e-Pub 2004.
- Amin HM, Pierce SA, Estey EH, Kantarjian HM, O’Brien SM, Giles FJ, Albitar M. Multilineage dysplasia is associated with worse clinical outcome independent of the diagnosis of acute myeloid leukemia or myelodysplastic syndrome. Blood 104:403A-404A, 2004. e-Pub 2004.
- Amin HM, Pierce SA, Kantarjian HM, Keating MJ, Freireich EJ, Koller CA, Beran M, Albitar M, O’Brien SM, Estey EH. Increased bone marrow erythroid precursors is associated with shorter survival in low-grade myelodysplastic syndromes. Blood 104:651A-652A, 2004. e-Pub 2004.
- Amin HM, Lai R, Lin Q, Feretzaki M, Grammatikakis I, Medeiros LJ, Rassidakis GZ. JAK3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Mod Pathol 17:238A, 2004. e-Pub 2004.
- Amin HM, Rassidakis GZ, Medeiros LJ, Ramdas L, Goy AH, Fugio Y, Kunisada K, Gilles F, Lai R. STAT3 activation contributes to high TIMP-1 expression in ALK-positive anaplastic large cell lymphoma. Mod Pathol 17:238A, 2004. e-Pub 2004.
- Bano A, Amin HM, Olatonade D, Dabbagh L, Lai R. ZAP70 expression in mantle cell lymphoma. Mod Pathol 17:239A, 2004. e-Pub 2004.
- Lee J, Ma Y, Franko B, Song X, Rassidakis GZ, Amin HM, Lai R. Expression of SHP1 splicing variant with dominant negative effects in malignant hematopoietic neoplasms. Mod Pathol 17:256A, 2004. e-Pub 2004.
- Oyarzo MP, Medeiros LJ, Feretzaki M, Amin HM, Rassidakis GZ. Activation of intrinsic apoptotic pathway in anaplastic large cell lymphoma. Mod Pathol 17:264A, 2004. e-Pub 2004.
- Rassidakis GZ, Feretzaki M, Grammatikakis I, Lin Q, Lai R, Medeiros LJ, Amin HM. Selective inhibition of Akt induces cell cycle arrest and apoptosis in anaplastic large cell lymphoma. Cold Spring Harbor Laboratory: Cancer Genetics and Tumor Suppressor Genes:175, 2004. e-Pub 2004.
- Li C, Lai R, Lin Q, Rassidakis GZ, Grammatikakis I, Hamilton SR, Amin HM. Inhibition of JAK3-STAT3 signaling pathway induces apoptosis and cell cycle arrest in human colon carcinoma cells. Keystone Symposia: Jaks and Stats: Development to disease:69, 2004. e-Pub 2004.
- Amin HM, Estey EH, Giles FJ, Pierce SA, Kantarjian HM, O’Brien SM, Albitar M. Clinical relevance of peripheral blood blasts in the myelodysplastic syndrome. Blood 102:424A, 2003. e-Pub 2003.
- Amin HM, Jilani I, Estey EH, Keating MJ, Diaz AL, Manshouri T, Kantarjian HM, Estrov Z, Cortes JE, Thomas DA, Giles FJ, Albitar M. Increased lymphocyte apoptosis in the myelodysplastic syndrome: implication of a critical role. Blood 100:373A, 2002. e-Pub 2002.
- Amin HM, Medeiros LJ, Manning JT, Jones D. The plasma cell variant of Castleman’s disease lacks uniform histologic and clinical features. Mod Pathol 15:228A, 2002. e-Pub 2002.
- Amin HM, Saeed S, Alkan S. Histone deacetylase inhibitors induce caspase-dependent apoptosis in acute promyelocytic leukemia with t(15;17). Mod Pathol 15:228A, 2002. e-Pub 2002.
- Ni H, Ergin M, Huang Q, J-Z Q, Amin HM, Pooley R, Alkan S. Analysis of NF-κB expression in multiple myeloma (MM): down-regulation of NF-κB induces apoptosis in MM. Mod Pathol 14:173A, 2001. e-Pub 2001.
- Alkan S, Ni H, Ergin M, Huang Q, J-Z Q, Amin HM, Pooley R. Inhibition of NF-κB induces apoptosis in multiple myeloma cell lines and chronic lymphocytic leukemia. Keystone Symposia: NF-κB regulation and function: from basic research to drug development:95, 2000. e-Pub 2000.
- Ergin M, Denning MF, Izban KF, Amin HM, Pooley RJ, Martinez RL, Alkan S. Analysis of tyrosine kinase NPM-ALK (p80) in anaplastic large cell lymphoma: inhibition of tyrosine kinase activity induces caspase-dependent apoptosis. Blood 96:341A, 2000. e-Pub 2000.
- Amin HM, Alkan S, Martinez RL, Huang JC. Analysis of Bcl-6 protein in primary B-cell non-Hodgkin’s lymphomas (B-NHLs) involving the gastrointestinal (GI) tract. Mod Pathol 13:142A, 2000. e-Pub 2000.
- Alkan S, Ergin M, Denning MF, Izban K, Pooley R, Amin HM. Protein kinase C (PKC)-δ is commonly expressed in Hodgkin’s lymphoma (HL) and its inhibition by rottlerin in HL cell line causes apoptosis. Mod Pathol 13:141A, 2000. e-Pub 2000.
- Amin HM, Ergin M, Denning MF, Quevedo ME, Wrone-Smith T, Huang JC, Alkan S. Characterization of apoptosis induced by protein kinase C inhibitors in retinoic acid sensitive and resistant acute promyelocytic leukemia cell line, NB4. Mod Pathol 13:141A, 2000. e-Pub 2000.
- Amin HM, Ergin M, Denning MF, Saeed S, Alkan S. Expression of protein kinase C (PKC) isoforms and the effect of selective PKC-δ inhibition by rottlerin on the induction of apoptosis in acute promyelocytic leukemia. Blood 96:208B, 2000. e-Pub 2000.
- Amin HM, Saeed S, Ergin M, Huang Q, Izban KF, Alkan S. Nuclear factor κB (NFκB) is constitutively expressed in acute lymphoblastic leukemia (ALL) and its inhibition induces caspase-dependent but cytochrome C-independent apoptosis. Blood 96:208B, 2000. e-Pub 2000.
- Huang Q, Ergin M, Ni H, J-Z Q, Amin HM, Alkan S. Inhibition of tyrosine kinase causes apoptosis and down-regulation of NFκB in IL-6 dependent and independent multiple myeloma cells. Blood 96:750A, 2000. e-Pub 2000.
- Pooley R, Ergin M, Denning MF, Amin HM, Nand S, Alkan S. Protein kinase C (PKC) in chronic lymphocytic leukemia (CLL): patterns of isoform expression and role in apoptosis. Mod Pathol 13:160A, 2000. e-Pub 2000.
- Amin HM, Lietz H, Hoppensteadt DA, Walenga JM, Ahmad S, Wolf H, Fareed J. Immuno-quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. Thromb Haemost 82(Suppl):354-355, 1999. e-Pub 1999.
- Amin HM, Petruzzelli GJ, Husain AN, Nickoloff BJ. Primary malignant melanoma of the larynx. A case report. Otolaryngol Head Neck Surg 119:P169-P170, 1998. e-Pub 1998.
- Amin HM, Lietz H, Hoppensteadt DA, Walenga JM, George M, Ahmad S, Fareed J. Quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. FASEB J 12:A1115, 1998. e-Pub 1998.
- Amin HM, Lietz H, Hoppensteadt DA, Walenga JM, George M, Ahmad S, Fareed J. Immuno-quantitation of soluble P-selectin in human plasma: effect of anticoagulant matrix and preliminary clinical data. Clin Chem 44:A51, 1998. e-Pub 1998.
- Amin HM, Rothko K, Zeller JA. Stability of four different thromboplastin reagents over 24 hours at 18°C. Thromb Haemost 78(Suppl):622, 1997. e-Pub 1997.
- Amin HM, Ferrario L, Sauro MD, Hakim TS, Camporesi EM. Effect of exposure to hyperbaric oxygen on nitric oxide production in the rat. FASEB J 10:A1018, 1996. e-Pub 1996.
- Amin HM, Ferrario L, Hakim TS, Camporesi EM. Effect of desferrioxamine versus PEG-superoxide dismutase on increased prostacyclin (PGI2) concentration after acute exposure to hyperbaric oxygen. FASEB J 10:A356, 1996. e-Pub 1996.
- Ferrario L, Amin HM, Camporesi EM, Hakim TS. Exhaled nitric oxide in endotoxin-treated rats: isolated perfused lung versus intact animal. FASEB J 10:A96, 1996. e-Pub 1996.
- Picone A, Lutz C, Gatto LA, Searles B, Paskanik A, Amin HM, Duesterhoeft D. Cardiopulmonary bypass (CPB) and endotoxin synergistically induce the adult respiratory distress syndrome (ARDS). Chest 110(Suppl):9S, 1996. e-Pub 1996.
- Amin HM, Ferrario L, Hakim TS, Camporesi EM. Effect of different durations of exposure to hyperbaric oxygen on circulating prostacyclin in the rat. Undersea Hyperb Med 23(Suppl):69, 1996. e-Pub 1996.
- Ferrario L, Amin HM, Weissbrich O, Hakim TS, Camporesi EM. Effect of hyperbaric oxygen exposure on exhaled nitric oxide in a septic rat model. Undersea Hyperb Med 23(Suppl):68, 1996. e-Pub 1996.
- Webster DA, Horn P, Amin HM, Weissbrich O, Mascia MF, Werner FW. Effect of hyperbaric oxygen exposure on ligament healing in a rat model. Undersea Hyperb Med 23(Suppl):11, 1996. e-Pub 1996.
- Ferrario L, Amin HM, Camporesi EM, Hakim TS. Measurement of expired nitric oxide concentration (eNO) in isolated lung preparation. Anesthesiology 85(Suppl):A1140, 1996. e-Pub 1996.
- Sugimori K, Ferrario L, Amin HM, Hakim TS, Camporesi EM. Effects of acute hyperbaric oxygen (HBO) exposure on vascular reactivity in isolated rat pulmonary arteries. FASEB J 9:A276, 1995. e-Pub 1995.
- Amin HM, Ferrario L, Sugimori K, Brennan S, Hakim TS, Camporesi EM. Effect of acute exposure to hyperbaric oxygen and 24 hours of recovery on prostacyclin concentration. FASEB J 9:A424, 1995. e-Pub 1995.
- Ferrario L, Amin HM, Sugimori K, Searles B, Camporesi EM, Hakim TS. Site of action of EDRF on pulmonary vasculature by using the double occlusion technique in the rat. FASEB J 9:A274, 1995. e-Pub 1995.
- O'Leary CE, Amin HM, Gilbert E, Paskanik AM, Hakim TS. Cardiovascular changes during isovolemic hemodilution with different colloid solutions in a swine model. FASEB J 9:A435, 1995. e-Pub 1995.
- Sugimori K, Amin HM, Ferrario L, Hakim TS, Camporesi EM. Changes in vascular reactivities of isolated aorta and pulmonary artery following acute exposure to hyperbaric oxygen [HBO] and 18 hours of recovery in rats. Undersea Hyperb Med 22(Suppl):63, 1995. e-Pub 1995.
- Ferrario L, Amin HM, Sugimori K, Brennan S, Hakim TS, Camporesi EM. Acute exposure to hyperbaric oxygen increases prostacyclin release in the pulmonary circulation. Undersea Hyperb Med 22(Suppl):65, 1995. e-Pub 1995.
- Amin HM, Ferrario L, Hakim TS, Camporesi EM. Effects of exposure to hyperbaric oxygen on blood rheology in the rat. Undersea Hyperb Med 22(Suppl):64, 1995. e-Pub 1995.
- Ferrario L, Amin HM, Sugimori K, Searles B, Camporesi EM, Hakim TS. Localization of the site of action of EDRF on pulmonary vasculature by using the double occlusion technique. Eighth Annual Charles Ross Research Poster Session Book of Abstracts:112, 1994. e-Pub 1994.
- Amin HM, O'Leary CE, Dracker RA, Camporesi EM, Hakim TS. Hematologic changes during isovolemic hemodilution with human albumin, hetastarch or pentastarch in domestic pigs. FASEB J 8:A902, 1994. e-Pub 1994.
- Sugimori K, Amin HM, Esposito BF, Seedat MS, Camporesi EM. Effect of slow vs. fast desaturation on ventilatory response to hypoxia in human volunteers. Eighth Annual Charles Ross Research Poster Session Book of Abstracts:111, 1994. e-Pub 1994.
- Amin HM, Sugimori K, Seedat MS, Esposito BF, Sopchak AM, Camporesi EM. Small doses of midazolam do not depress the ventilatory responses to progressively induced hypoxia. Anesthesiology 81(Suppl):A1411, 1994. e-Pub 1994.
- Amin HM, Hakim TS, Camporesi EM. Changes in the plasma proteins following acute exposure to hyperbaric oxygen and 24 hours of recovery in rats. Undersea Hyperb Med 21(Suppl):35, 1994. e-Pub 1994.
- Amin HM, Cohen D, Paskanik AM, Hakim TS, Camporesi EM. Acute exposure to hyperbaric oxygen decreases the deformability of the red blood cells. Undersea Hyperb Med 21(Suppl):80, 1994. e-Pub 1994.
- Sugimori K, Amin HM, Esposito BF, Mascia MF, Camporesi EM. Effect of slow vs. fast desaturation on ventilatory response to hypoxia. Anesthesiology 81(Suppl):A1413, 1994. e-Pub 1994.
- Amin HM, Kaniewski WS, Paskanik AM, Camporesi EM, Hakim TS. Changes in blood rheology following acute exposure to hyperbaric oxygen [HBO]. FASEB J 7:A350, 1993. e-Pub 1993.
- Amin HM, Cohen D, Hakim TS, Camporesi EM. Blood alterations after acute hyperbaric oxygen [HBO] exposure. Crit Care Med 20:A96, 1993. e-Pub 1993.
- Amin HM, Kaniewski WS, Hakim TS, Camporesi EM. Hematological changes following acute exposure to hyperbaric oxygen [HBO] and 24 hours of recovery in rats. Undersea Hyperb Med 20(Suppl):66, 1993. e-Pub 1993.
- Amin HM, Sopchak AM, Esposito BF, Foss JF, Hays-Benedict J, Roizen MF, Camporesi EM. Methylnaltrexone does not reverse morphine-induced depression of hypoxic drive. Anesthesiology 78(Suppl):A1204, 1993. e-Pub 1993.
- Amin HM, Sopchak AM, Esposito BF, Graham CL, Batenhorst RL, Camporesi EM. Naloxone reversal of depressed ventilatory response to hypoxia during continuous infusion of remifentanil. Anesthesiology 78(Suppl):A1203, 1993. e-Pub 1993.
- Amin HM, Hakim TS, Camporesi EM. Pulmonary mechanical responses after hyperbaric O2 (HBO) exposure and 24 hours of recovery in rats. Undersea Biomed Res 19(Suppl):32, 1992. e-Pub 1992.
- Amin HM, Hakim TS, Camporesi EM. Pulmonary vascular responses after acute hyperbaric oxygen [HBO] exposure. Anesthesiology 77(Suppl):A636, 1992. e-Pub 1992.
- Amin HM, Hakim TS, Camporesi EM. Blood viscosity increases after acute hyperbaric oxygen [HBO] exposure. Anesthesiology 77(Suppl):A635, 1992. e-Pub 1992.
- Amin HM, Hakim TS, Camporesi EM. Blood viscosity changes after exposure to hyperbaric O2 (HBO) in rats. Undersea Biomed Res 19(Suppl):197, 1992. e-Pub 1992.
- Cigada M, Amin HM, Hakim TS, Camporesi EM. Abolition of the reflex of hypoxic pulmonary vasoconstriction after exposure to hyperbaric oxygen [Italian]. Minerva Anestesiol 57:979, 1991. e-Pub 1991.
- Amin HM, Cigada M, Hakim TS, Camporesi EM. Lung mechanics after short exposure to hyperbaric oxygen (HBO) in rats. Undersea Biomed Res 18(Suppl):30, 1991. e-Pub 1991.
- Cigada M, Amin HM, Winters T, Hakim TS, Camporesi EM. Pulmonary vasculature after short exposure to hyperbaric oxygen (HBO) in rats. Undersea Biomed Res 18(Suppl):29, 1991. e-Pub 1991.
- Salem A, Routbort MJ, Khoury JD, Wang SA, Shamanna RK, Ok CY, Patel K, Zuo Z, Thakral B, Schlette EJ, Yin C, Amin HM, Luthra R, Bueso-Ramos CE, Medeiros LJ, Lghavi S. Incidental MYD88 L265P mutation in patients with myeloid neoplasms; a clue to occult B-cell lymphoproliferative disorders. USCAP.
Book Chapters
- Masarova L, Amin HM, Chifotides HT. Philadelphia chromosome-negative myeloproliferative neoplasms. In: The MD Anderson Manual of Medical Oncology. McGrew-Hill Professional, 2026.
- Bose P, Verstovsek S, Amin HM. Philadelphia chromosome-negative myeloproliferative neoplasms. In: The MD Anderson Manual of Medical Oncology. McGraw-Hill Professional, 2022.
- Verstovsek S, Newberry KJ, Amin HM. Philadelphia chromosome-negative myeloproliferative neoplasms. In: The MD Anderson Manual of Medical Oncology. McGraw-Hill Professional, 103-130, 2016.
- Jain N, Amin HM, Verstovsek S. Philadelphia chromosome negative myeloproliferative neoplasms. In: The MD Anderson Manual of Medical Oncology. 2nd edition. McGraw-Hill Professional, 97-121, 2011.
- Verstovsek S, El-Ahdab SY, Amin HM. Other myeloproliferative diseases. In: Atlas of Cancer. 2nd edition. Current Medicine Group LLC, Springer, 334-344, 2008.
- Goy AH, Amin HM, Cabanillas F, Medeiros LJ. Diagnosis and management of other lymphoproliferative disorders. In: Non-Hodgkin’s Lymphomas. Lippincott, Williams, and Wilkins, 657-683, 2004.
- Curry JL, Amin HM, Theil KS. Synovial, pleural, and peritoneal fluids. In: Clinical Laboratory Medicine. 2nd edition. Lippincott, Williams, and Wilkins, 501-518, 2001.
- Huang JC, Amin HM, Alkan S. Chronic myeloproliferative disorders. In: Clinical Laboratory Medicine. 2nd edition. Lippincott, Williams, and Wilkins, 964-984, 2001.
- Hakim TS, Amin HM, Ferrario L, Camporesi EM. Hyperoxia-induced injury in the pulmonary circulation. In: Proceedings of the International Symposium on Update of Hyperbaric Oxygen Therapy. La Commerciale, 168-173, 1995.
Books (edited and written)
- McClatchey KD, Amin HM, Curry JL. Clinical Laboratory Medicine Self-Assessment and Review. Ed(s) 2nd edition. Lippincott, Williams, and Wilkins, 2002.
Letters to the Editor
- Morris JS, Hassan M, Amin HM, Kaseb A. REPLY:. Hepatology 73: 2614, 2021.
- Morris JS, Hassan M, Amin HM, Kaseb A. REPLY:. Hepatology 73: 2612, 2021.
- Hui D, Dabbagh L, Hanson J, Amin HM, Lai R. High ZAP-70 expression correlates with worse clinical outcome in mantle cell lymphoma. Leukemia 20: 1905-1908, 2006.
- Amin HM, Lin Q, Lai R. Jak3 contributes to the activation of ALK and Stat3 in ALK+ anaplastic large cell lymphoma. Lab Invest 86: 417-419, 2006.
- Sun X, Amin HM, Freireich EJ, Keating MJ, Kantarjian HM, Koller CA, O’Brien SM, Giles F, Albitar M. Hairy cell leukemia with large cells: long disease course with adequate response to therapy. Leukemia 18: 1912-1914, 2004.
- Khoury JD, Rassidakis GZ, Medeiros LJ, Amin HM, Lai R. Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma. Blood 104: 1580-1581, 2004.
- Amin HM, Zeller JA, Shen T, Nassar A. Sensitivity and specificity of the APC resistance assay in detection of individuals with factor VLeiden. Am J Clin Pathol 107: 713-715, 1997.
- Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X, Gong Y, Shen H, Yin C, Jones D, Amin HM, You MJ, Zweidler-McKay P, Ma Y, Kantrajian HM, Arlinghaus RB, Glassman, A, Sun X. Sox4 is essential for initiation and progression of acute lymphoblastic leukemia induced by p190 BCR-ABL. Leukemia.
Patient Reviews
CV information above last modified March 26, 2026