Hui-Lin Pan, M.D., Ph.D.

Peer-Reviewed Articles

1. Wan K, Huang J, Xu Q, Cui C, Shi Y, Lei J, Fang Z, Xu T, Zheng Y, Wu J, Zhu Z, Liang Y, Zhang Y, Pan H, Peng P, Jing X, Li M. The ENKRVM→SRD projection constitutes a functionally specific circuit for bidirectional pain modulation. CNS Neurosci Ther 32(7), 2026. e-Pub 2026. PMID: 42518076.
2. Jin D, Chen H, Huang Y, Chen SR, Pan H. Sensory neuron BRAF medicates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity. J Clin Invest, 2026. e-Pub 2026.
3. Wei S, Xu J, Chen SR, Huang Y, Jarrett Z, Godlewski G, Paloczi J, Pacher P, Pan H, Xu Y, Lovinger D, Zhang L. Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism. Int J Biol Sci 22(12):6631-6652, 2026. e-Pub 2026. PMID: 42524505.
4. Tiwari, A, Subedi, A, Etemad, A, Huang, Y, Chatterjee, B, McLeod, SM, Lu, Y, Song, EM, Gonzalez, DA, Singh, S, Lee, JJ, Pan, H, Majumder, S. Sex differences in nerve injury-induced neuropathic pain via REST in primary sensory neurons. Neurobiology of Pain 20, 2026. e-Pub 2026. PMID: 42169728.
5. Gautam V, Huang Y, Chen H, Chen SR, Pan H. HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1–Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses. J Neuroscience 46(25), 2026. e-Pub 2026.
6. Liu, N, Shi, X, Chen, S, Chen, H, Santi, MD, Phuong, DM, Fialho, MP, Xie, T, Gleber-Netto, FO, Latorre, R, Bunnett, NW, Viet, CT, Amit, M, Pan, H, Ye, Y. EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer. Science Signaling 19(922):eadt3026, 2026. e-Pub 2026. PMID: 41592151.
7. Jin D, Chen H, Huang Y, Chen SR, Pan H. BRAF recruitment to spinal sensory synapses promotes neuropathic pain through transsynaptic NMDA receptor hyperactivity. Science Signal. e-Pub 2026.
8. Yuying Huang, Hong Chen, Shao-Rui Chen, Pan H. Tonic GABA and Glycine Inhibition Control Pain Hypersensitivity via Limiting α2δ-1- and mGluR5-Dependent NMDA Receptor Activity at Primary Afferent→Excitatory Neuron Synapses. J Neurosci 45(44), 2025. e-Pub 2025. PMID: 41006062.
9. Meng- Hua Zhou, Shao-Rui Chen, Daozhong Jin, Yuying Huang, Hong Chen, Guanxing Chen, Jiusheng Yan, Pan H. Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity. J Clin Invest 136(1), 2025. PMID: 41129242.
10. Meichun Deng, Shao-Rui Chen, Meng-Hua Zhou, Jixiang Zhang, Yuying Huang, Hong Chen, Fernando Benavides, Rajan Sah, Pan H. LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses. Sci Transl Med 17(821), 2025. PMID: 41124282.
11. Daozhong Jin, Hong Chen, Meng-Hua Zhou, Yuying Huang, Shao-Rui Chen, Pan H. Gαq signaling in primary sensory neurons shifts opioid analgesia to NMDA receptor-driven tolerance and hyperalgesia. Sci Signal 18(902), 2025. PMID: 40892896.
12. Zhou ZZ, Shao JY, Chen SR, Ye ZY, Pan H. RCAN1-mediated calcineurin inhibition in the hypothalamus enhances NMDA receptor–driven sympathetic outflow in hypertension. Circ Res 137(3):417-434, 2025. e-Pub 2025. PMID: 40510021.
13. Zhanmu, OY, Yang, Y, Feng, B, Wang, HY, Li, H, Zhou, HJ, Ge, W, Wan, K, Wang, SX, Zhang, KL, Zhang, H, Pei, L, Pan, H, Tian, Q, Li, M. Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons. Acta Pharmacologica Sinica 46(4):904-921, 2025. e-Pub 2025. PMID: 39663420.
14. Zhou, M, Zhou, J, Chen, S, Chen, H, Jin, D, Huang, Y, Shao, JY, Pan, H. α2δ-2 regulates synaptic GluK1 kainate receptors in Purkinje cells and motor coordination. Brain 148(4):1271-1285, 2025. e-Pub 2025. PMID: 39439207.
15. Wan, K, Xu, Q, Shi, Y, Cui, C, Lei, J, Zhang, KL, Yao, Q, Rao, Y, Zhou, Z, Wu, Y, Mei, J, Pan, H, Jing, XH, Zhu, H, Li, M. Electroacupuncture produces analgesic effects via cannabinoid CB1 receptor-mediated GABAergic neuronal inhibition in the rostral ventromedial medulla. Chinese Medicine (United Kingdom) 20(1), 2025. e-Pub 2025. PMID: 40038719.
16. Ghosh, K, Huang, Y, Jin, D, Chen, S, Pan, H. Histone Methyltransferase G9a in Primary Sensory Neurons Promotes Inflammatory Pain and Transcription of Trpa1 and Trpv1 via Bivalent Histone Modifications. Journal of Neuroscience 45(6), 2025. e-Pub 2025. PMID: 39824634.
17. Xiang, HC, Lan, Y, Hu, L, Qin, R, Li, HP, Weng, T, Zou, Y, Liu, Y, Hu, XF, Ge, W, Zhang, H, Pan, H, Yang, NN, Liu, WT, Cai, G, Li, M. AMPK activation mitigates inflammatory pain by modulating STAT3 phosphorylation in inflamed tissue macrophages of adult male mice. Molecular pain 21, 2025. e-Pub 2025. PMID: 39921559.
18. Chen G, Guan X, Wei H, Cai YQ, Pan Z, Pan H, Yan J. Transgenic expression of BK channel auxiliary LRRC26 subunit in the forebrain causes locomotor hyperactivity and cognitive defects. eNeuro. e-Pub 2025.
19. Lan, Y, Jing, XH, Zhou, Z, Rao, Y, Wang, K, Qin, R, Wu, Y, Sun, J, Zhang, K, Liu, X, Wang, Z, Xu, J, zhao, M, Yuan, XC, Liu, Y, Zhang, H, Hu, XF, Pan, H, Hou, TF, Li, M. Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway. Chinese Medicine (United Kingdom) 19(1), 2024. e-Pub 2024. PMID: 39719630.
20. Subedi, A, Etemad, A, Tiwari, A, Huang, Y, Chatterjee, B, McLeod, SM, Lu, Y, Gonzalez, DA, Ghosh, K, Sirito, M, Singh, S, Ruiz, E, Grimm, SL, Coarfa, C, Pan, H, Majumder, S. Nerve injury inhibits Oprd1 and Cnr1 transcription through REST in primary sensory neurons. Scientific reports 14(1), 2024. e-Pub 2024. PMID: 39496614.
21. Ghosh, K, Huang, Y, Chen, S, Pan, H. Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone deacetylase HDAC2 in dorsal root ganglia. Journal of Biological Chemistry 300(11), 2024. e-Pub 2024. PMID: 39357831.
22. Huang, Y, Chen, S, Shao, JY, Pan, H, Zhou, J, Chen, H. Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons. Journal of Neuroscience 44(29), 2024. e-Pub 2024. PMID: 38886057.
23. Zhou, J, Shao, JY, Chen, S, Chen, H, Pan, H. Calcineurin regulates synaptic Ca2+-permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly. Journal of Physiology 602(10):2179-2197, 2024. e-Pub 2024. PMID: 38630836.
24. Ghosh, K, Zhou, J, Shao, JY, Chen, S, Pan, H. DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. Journal of Biological Chemistry 300(2), 2024. e-Pub 2024. PMID: 38160798.
25. Huang, Y, Chen, S, Pan, H, Chen, H, Shao, JY, Zhou, J. Constitutive KCC2 Cell- and Synapse-Specifically Regulates NMDA Receptor Activity in the Spinal Cord. Journal of Neuroscience 44(4), 2024. e-Pub 2024. PMID: 38124193.
26. Zhou, J, Shao, JY, Chen, S, Pan, H. Brain α2δ-1-Bound NMDA Receptors Drive Calcineurin Inhibitor-Induced Hypertension. Circulation research 133(7):611-627, 2023. e-Pub 2023. PMID: 37605933.
27. Jin, D, Chen, H, Zhou, M, Chen, S, Pan, H. mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors. Journal of Neuroscience 43(31):5593-5607, 2023. e-Pub 2023. PMID: 37451981.
28. Sheng, ZF, Zhang, H, Phaup, JG, Zheng, PR, Kang, X, Liu, Z, Chang, HM, Yeh, E, Johnson, AK, Pan, H, Li, DP. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovascular Research 119(8):1751-1762, 2023. e-Pub 2023. PMID: 37041718.
29. Ma, H, Cui, Z, Guo, X, Zhao, Q, Zhang, Y, Guan, Y, Yang, P, Zhu, H, Wang, S, Zhang, X, Zhang, Y, Pan, H, Ma, HJ. Corticotropin-releasing factor potentiates glutamatergic input and excitability of presympathetic neurons in the hypothalamus in spontaneously hypertensive rats. Neuropharmacology 230, 2023. e-Pub 2023. PMID: 36924924.
30. Huang, Y, Chen, H, Jin, D, Chen, S, Pan, H. NMDA Receptors at Primary Afferent–Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain. Journal of Neuroscience 43(21):3933-3948, 2023. e-Pub 2023. PMID: 37185237.
31. Huang, Y, Chen, H, Chen, S, Pan, H. Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors. ACS Chemical Neuroscience 14(7):1261-1277, 2023. e-Pub 2023. PMID: 36930958.
32. Jin, D, Chen, H, Chen, S, Pan, H. α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry 164(2):143-157, 2023. e-Pub 2023. PMID: 36222452.
33. Chen, S, Chen, H, Jin, D, Pan, H. Brief Opioid Exposure Paradoxically Augments Primary Afferent Input to Spinal Excitatory Neurons via α2δ-1–Dependent Presynaptic NMDA Receptors. Journal of Neuroscience 42(50):9315-9329, 2022. e-Pub 2022. PMID: 36379705.
34. Dwivedi, S, Gottipati, A, Ganugula, R, Arora, M, Friend, R, Osburne, R, Rodrigues-Hoffman, A, Basu, R, Pan, H, Kumar, MN. Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats. Molecular Pharmaceutics 19(12):4612-4624, 2022. e-Pub 2022. PMID: 36106748.
35. Zhang, J, Chen, S, Zhou, M, Jin, D, Chen, H, Wang, L, DePinho, RA, Pan, H. HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity. Journal of Neuroscience 42(48):8918-8935, 2022. e-Pub 2022. PMID: 36257688.
36. Jin, D, Chen, H, Huang, Y, Chen, S, Pan, H. δ-Opioid receptors in primary sensory neurons tonically restrain nociceptive input in chronic pain but do not enhance morphine analgesic tolerance. Neuropharmacology 217, 2022. e-Pub 2022. PMID: 35917874.
37. Ge, W, Zhan-mu, OY, Chen, C, Zhang, H, Wang, XY, Liu, X, Li, L, Lan, Y, Li, CN, Sun, JC, Shi, RL, Dou, ZY, Pan, H, Li, HP, Jing, XH, Li, M. Electroacupuncture reduces chronic itch via cannabinoid CB1 receptors in the ventrolateral periaqueductal gray. Frontiers in Pharmacology 13, 2022. e-Pub 2022. PMID: 36133809.
38. Zhou, J, Shao, JY, Chen, S, Pan, H. Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow. Circulation research 131(4):345-360, 2022. e-Pub 2022. PMID: 35862168.
39. Hu, XF, Zhang, H, Yu, LL, Ge, W, Zhan-mu, OY, Li, YZ, Chen, C, Hou, TF, Xiang, HC, Li, YH, Su, YS, Jing, XH, Cao, J, Pan, H, He, W, Li, M. Electroacupuncture Reduces Anxiety Associated With Inflammatory Bowel Disease By Acting on Cannabinoid CB1 Receptors in the Ventral Hippocampus in Mice. Frontiers in Pharmacology 13, 2022. e-Pub 2022. PMID: 35873560.
40. Ghosh, K, Zhang, G, Chen, H, Chen, S, Pan, H. Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain. Journal of Biological Chemistry 298(6), 2022. e-Pub 2022. PMID: 35500651.
41. Zhou, J, Shao, JY, Chen, S, Chen, H, Pan, H. α2δ-1 protein promotes synaptic expression of Ca2+ permeable–AMPA receptors by inhibiting GluA1/GluA2 heteromeric assembly in the hypothalamus in hypertension. Journal of neurochemistry 161(1):40-52, 2022. e-Pub 2022. PMID: 35038178.
42. Zhang, H, He, W, Hu, XF, Li, YZ, Liu, Y, Ge, W, Zhanmu, OY, Chen, C, Lan, Y, Su, YS, Jing, XH, Zhu, B, Pan, H, Yu, LL, Li, M. Electroacupuncture Reduces Visceral Pain Via Cannabinoid CB2 Receptors in a Mouse Model of Inflammatory Bowel Disease. Frontiers in Pharmacology 13, 2022. e-Pub 2022. PMID: 35401205.
43. Sheng, ZF, Zhang, H, Zheng, PR, Chen, S, Gu, Z, Zhou, J, Phaup, JG, Chang, HM, Yeh, E, Pan, H, Li, DP. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovascular Research 118(2):585-596, 2022. e-Pub 2022. PMID: 33512443.
44. Huang, Y, Chen, S, Chen, H, Zhou, J, Jin, D, Pan, H. Theta-Burst Stimulation of Primary Afferents Drives LongTerm Potentiation in the Spinal Cord and Persistent Pain via α2δ-1-Bound NMDA Receptors. Journal of Neuroscience 42(3):513-527, 2022. e-Pub 2022. PMID: 34880118.
45. Liu, Y, Jia, M, Wu, CH, Zhang, H, Chen, C, Ge, W, Wan, K, Lan, Y, Liu, S, Li, Y, Fang, M, He, J, Pan, H, Si, JQ, Li, M. Transcriptomic Profiling in Mice With CB1 receptor Deletion in Primary Sensory Neurons Suggests New Analgesic Targets for Neuropathic Pain. Frontiers in Pharmacology 12, 2022. e-Pub 2022. PMID: 35046811.
46. Wu, CH, Liu, Y, Wan, K, Lan, Y, Jia, M, Lin, LX, Gao, S, Chen, K, Yang, J, Pan, H, Li, M, Mao, H. Long Non-Coding RNA and mRNA Profiles in the Spinal Cord of Rats with Resiniferatoxin-Induced Neuropathic Pain. Journal of Pain Research 15:2149-2160, 2022. e-Pub 2022. PMID: 35935680.
47. Zhou, M, Chen, S, Wang, L, Huang, Y, Deng, M, Zhang, J, Zhang, J, Chen, H, Yan, J, Pan, H. Protein kinase C-mediated phosphorylation and a2d-1 interdependently regulate NMDA receptor trafficking and activity. Journal of Neuroscience 41(30):6415-6429, 2021. e-Pub 2021. PMID: 34252035.
48. Zhou, J, Shao, JY, Chen, S, Li, DP, Pan, H. a2d-1–dependent NMDA receptor activity in the hypothalamus is an effector of genetic-environment interactions that drive persistent hypertension. Journal of Neuroscience 41(30):6551-6563, 2021. e-Pub 2021. PMID: 34193557.
49. Li, L, Chen, S, Zhou, M, Wang, L, Li, DP, Chen, H, Lee, G, Jayaraman, V, Pan, H. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports 36(3), 2021. e-Pub 2021. PMID: 34289359.
50. Zhang, G, Chen, S, Jin, D, Huang, Y, Chen, H, Pan, H. a2d-1 upregulation in primary sensory neurons promotes NMDA receptor-mediated glutamatergic input in resiniferatoxin-induced neuropathy. Journal of Neuroscience 41(27):5963-5978, 2021. e-Pub 2021. PMID: 34252037.
51. Zhou JJ, Pachuau J, Li DP, Chen SR, Pan H. Group III metabotropic glutamate receptors regulate hypothalamic presympathetic neurons through opposing presynaptic and postsynaptic actions in hypertension. Neuropharmacology 174, 2020. e-Pub 2020. PMID: 32454125.
52. Huang Y, Chen SR, Chen H, Luo Y, Pan H. Calcineurin inhibition causes α2δ-1-mediated tonic activation of synaptic NMDA receptors and pain hypersensitivity. J Neurosci 40(19):3707-3719, 2020. e-Pub 2020. PMID: 32269108.
53. Luo Y, Zhang J, Chen L, Chen SR, Chen H, Zhang G, Pan H. Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain. J Biol Chem 295(11):3553-3562, 2020. e-Pub 2020. PMID: 32024693.
54. Sun J, Chen SR, Pan H. μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. Brain Res 1729, 2020. e-Pub 2020.
55. Chen SR, Zhang J, Chen H, Pan H. Streptozotocin-Induced Diabetic Neuropathic Pain Is Associated with Potentiated Calcium-Permeable AMPA Receptor Activity in the Spinal Cord. J Pharmacol Exp Ther 371(2):242–249, 2019. e-Pub 2019. PMID: 31481518.
56. Zou G, Chen Q, Chen K, Zuo X, Ge Y, Hou Y, Pan T, Pan HL, Liu D, Zhang L, Xiong Wei. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience 19:634-646, 2019. e-Pub 2019. PMID: 31450193.
57. Ma H, Chen SR, Chen H, Pan H. Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension. J Physiol 597(16):4325-4340, 2019. e-Pub 2019. PMID: 31241170.
58. Deng M, Chen SR, Chen H, Pan HL. a2a-1-Bound NMDA receptors mediate opioid-induced hyperalgesia and tolerance by potentiating glutamatergic input in rodents. Anesthesiology 130(5):804-819, 2019. e-Pub 2019. PMID: 30839350.
59. Huang Y, Chen SR, Chen H, Pan HL. Endogenous TRPV1 and TRPA1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem 149(3):381-398, 2019. e-Pub 2019. PMID: 30716174.
60. Li HP, Su W, Shu Y, Yuan XC, Lin LX, Hou TF, Xiang CH, Zhu H, Hu XF, Pan L, Wu JN, Meng XF, Pan HL, Wu CH, Li M. Electroacupuncture decreases Netrin-1-induced myelinated afferent fiber sprouting and neuropathic pain through μ-opioid receptors. J Pain Res 12:1259-1268, 2019. e-Pub 2019. PMID: 31118749.
61. Ganugula R, Deng M, Arora M, Pan H, Kumar MNVR. Polyester nanoparticle encapsulation mitigates paclitaxel-induced peripheral neuropathy. ACS Chem Neurosci 10(3):1801-1812, 2019. e-Pub 2019. PMID: 30609902.
62. Sun J, Chen SR, Chen H, Pan HL. μ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol 597(6):1661-1675, 2019. e-Pub 2019. PMID: 30578671.
63. Xiang HC, Lin LX, Hu XF, Zhu H, Li HP, Zhang RY, Hu L, Liu WT, Zhao YL, Shu Y, Pan H, Li M. AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression. J Neuroinflammation 16(1):34, 2019. e-Pub 2019. PMID: 30755236.
64. Deng M, Chen SR, Chen H, Luo Y, Dong Y, Pan HL. Mitogen-activated protein kinase signaling mediates opioid-induced presynaptic NMDA receptor activation and analgesic tolerance. J Neurochem 148(2):275-290, 2019. e-Pub 2019. PMID: 30444263.
65. Chen Y, Chen SR, Chen H, Zhang J, Pan HL. Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. J Neurochem 148(2):252-274, 2019. e-Pub 2019. PMID: 30431158.
66. Zhou JJ, Li DP, Chen SR, Luo Y, Pan HL. The α2δ-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory. J Biol Chem 293(50):19354-19364, 2018. e-Pub 2018. PMID: 30355732.
67. Zhang J, Chen SR, Chen H, Pan HL. RE1-silencing transcription factor controls the acute-to-chronic neuropathic pain transition and Chrm2 receptor gene expression in primary sensory neurons. J Biol Chem 293(49):19078-19091, 2018. e-Pub 2018. PMID: 30327427.
68. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. J Neurochem 147(4):526-540, 2018. e-Pub 2018. PMID: 30203849.
69. Zhang J, Guan X, Li Q, Meredith AL, Pan HL, Yan J. Glutamate-activated BK channel complexes formed with NMDA receptors. Proc Natl Acad Sci U S A 115(38):E9006-E9014, 2018. e-Pub 2018. PMID: 30181277.
70. Garriga J, Laumet G, Chen SR, Zhang Y, Madzo J, Issa JJ, Pan HL, Jelinek J. Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion. J Neurosci 38(27):6090-6101, 2018. e-Pub 2018. PMID: 29875269.
71. Zhang X, Chen S, Chen H, Pan H, Zhao Y. Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors. Mol Neurobiol 55(6):5393-5407, 2018. e-Pub 2018. PMID: 28975565.
72. Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep 22(9):2307-2321, 2018. e-Pub 2018. PMID: 29490268.
73. Gao F, Xiang HC, Li HP, Jia M, Pan XL, Pan HL, Li M. Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain. Brain Behav Immun 67:91-100, 2018. e-Pub 2018. PMID: 28782714.
74. Yuan XC, Zhu B, Jing XH, Xiong LZ, Wu CH, Gao F, Li HP, Xiang HC, Zhu H, Zhou B, He W, Lin CY, Pan HL, Wang Q, Li M. Electroacupuncture Potentiates Cannabinoid Receptor-Mediated Descending Inhibitory Control in a Mouse Model of Knee Osteoarthritis. Front Mol Neurosci 11:112, 2018. e-Pub 2018. PMID: 29681797.
75. Ma H, Chen SR, Li L, Li DP, Pan HL. α2δ-1 is essential for angiotensin II-induced sympathetic output and NMDA receptor hyperactivity in the hypothalamus. J Neurosci 38:6388-6398, 2018. e-Pub 2018.
76. Ma H, Chen SR, Chen H, Zhou JJ, Li DP, Pan HL. α2δ-1 couples to NMDA receptors in the hypothalamus to sustain sympathetic vasomotor activity in hypertension. J Physiol 596:4269-4283, 2018. e-Pub 2018.
77. Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt C, Deng M, Zhou MH, Huang Y, Gaitan-Penas H, Guenet JL, Chen T, Bedford MT, Dent SR, Richburg JH, Estevez R, Pan HL, Geha RS, Shi Q, Benavides F. LRRC8A-dependent volume-regulated anion channel activity is essential for male fertility in mice. JCI Insight 3, 2018. e-Pub 2018.
78. Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Chen L, Pan HL. Focal cerebral ischemia and reperfusion induce brain injury through α2δ-1-bound NMDA receptors. Stroke 49:2464-2472, 2018. e-Pub 2018.
79. Xie JD, Chen SR, Pan HL. Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain. J Biol Chem 292(50):20644-20654, 2017. e-Pub 2017. PMID: 29074619.
80. Li DP, Zhou JJ, Zhang J, Pan HL. CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. J Neurosci 37(44):10690-10699, 2017. e-Pub 2017. PMID: 28972129.
81. Chen SR, Jin XG, Pan HL. Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury. Neuropharmacology 125:156-165, 2017. e-Pub 2017. PMID: 28754372.
82. Xie JD, Chen SR, Chen H, Pan HL. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cords. Neuropharmacology 123:477-487, 2017. e-Pub 2017. PMID: 28663117.
83. Chen SR, Chen H, Zhou JJ, Pradhan G, Sun Y, Pan HL, Li DP. Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons. J Neurochem 142(4):512-520, 2017. e-Pub 2017. PMID: 28547758.
84. Qiao X, Zhou JJ, Li DP, Pan HL. Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Vasomotor Tone in Hypertension. Hypertension 69(1):154-162, 2017. e-Pub 2017. PMID: 27802416.
85. Wu CH, Yuan XC, Gao F, Li HP, Cao J, Liu YS, Yu W, Tian B, Meng XF, Shi J, Pan HL, Li M. Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain. Mol Neurobiol 53(8):5640-51, 2016. e-Pub 2016. PMID: 26482371.
86. Xie JD, Chen SR, Chen H, Zeng WA, Pan HL. Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain. J Biol Chem 291(37):19364-73, 2016. e-Pub 2016. PMID: 27458019.
87. Gao F, Zhang LH, Su TF, Li L, Zhou R, Peng M, Wu CH, Yuan XC, Sun N, Meng XF, Tian B, Shi J, Pan HL, Li M. Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release. Mol Neurobiol 53(6):3616-25, 2016. e-Pub 2016. PMID: 26108183.
88. Klein SM, Vykoukal J, Li DP, Pan HL, Zeitler K, Alt E, Geis S, Felthaus O, Prantl L. Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue-Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration-Approved Nerve Conduit. Plast Reconstr Surg 138(1):132-9, 2016. e-Pub 2016. PMID: 27348645.
89. Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep 15(7):1376-83, 2016. e-Pub 2016. PMID: 27160909.
90. Zhang Y, Chen SR, Laumet G, Chen H, Pan HL. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons. J Biol Chem 291(16):8475-85, 2016. e-Pub 2016. PMID: 26917724.
91. Zhu Y, Chen SR, Pan HL. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem 137(2):226-39, 2016. e-Pub 2016. PMID: 26823384.
92. Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci 18(12):1746-55, 2015. e-Pub 2015. PMID: 26551542.
93. Zhou MH, Bavencoffe A, Pan HL. Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation. J Biol Chem 290(51):30616-23, 2015. e-Pub 2015. PMID: 26507659.
94. Li DP, Zhou JJ, Pan HL. Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension. J Physiol 593(19):4439-52, 2015. e-Pub 2015. PMID: 26174743.
95. Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL. Pannexin-1 Upregulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem 290(23):14647-55, 2015. e-Pub 2015. PMID: 25925949.
96. Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci 35(8):3312-8, 2015. e-Pub 2015. PMID: 25716832.
97. Xu SG, Mao ZG, Liu BS, Zhu HH, Pan HL. Evaluating the use of antibiotic prophylaxis during open reduction and internal fixation surgery in patients at low risk of surgical site infection. Injury S0020-1383(14):00356-8, 2015. e-Pub 2015. PMID: 25152430.
98. Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol 86(6):760-72, 2014. e-Pub 2014. PMID: 25267719.
99. Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL. Increased Spinal Cord Na+-K+-2Cl- Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain. J Biol Chem 289(45):31111-20, 2014. e-Pub 2014. PMID: 25253692.
100. Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem 130(5):657-67, 2014. e-Pub 2014. PMID: 24806793.
101. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron 83(5):1159-71, 2014. e-Pub 2014. PMID: 25189211.
102. Chen SR, Zhou HY, Byun HS, Chen H, Pan HL. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther 350(2):301-12, 2014. e-Pub 2014. PMID: 24898266.
103. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem 289(20):14321-30, 2014. e-Pub 2014. PMID: 24695732.
104. Xia H, Zhang D, Yang S, Wang Y, Xu L, Wu J, Ren J, Yao W, Fan L, Zhang C, Tian Y, Pan HL, Wang X. Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. Brain Res 1554:29-35, 2014. e-Pub 2014. PMID: 24480471.
105. Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. J Neurosci 34(12):4309-17, 2014. e-Pub 2014. PMID: 24647951.
106. Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17(2):232-9, 2014. e-Pub 2014. PMID: 24390226.
107. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol 592(Pt 1):215-27, 2014. e-Pub 2014. PMID: 24081160.
108. Chen SR, Zhou HY, Byun HS, Pan HL. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: Functional significance and signaling mechanisms. J Pharmacol Exp Ther 347(3):765-72, 2013. e-Pub 2013. PMID: 24030012.
109. Ye ZY, Li DP, Pan HL. Regulation of hypothalamic presympathetic neurons and sympathetic outflow by group II metabotropic glutamate receptors in spontaneously hypertensive rats. Hypertension 62(2):255-62, 2013. e-Pub 2013. PMID: 23716583.
110. Guo YX, Li DP, Chen SR, Pan HL. Distinct intrinsic and synaptic properties of pre-sympathetic and pre-parasympathetic output neurons in Barrington's nucleus. J Neurochem 126(3):338-48, 2013. e-Pub 2013. PMID: 23647148.
111. Wu CH, LV ZT, Zhao Y, Gao Y, Li JQ, Gao F, Meng XF, Tian B Shi J, Pan HL, Li M. Electroacupunture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia. Mol Pain 9(18), 2013. e-Pub 2013. PMID: 23551937.
112. Cai YQ, Chen SR, Pan HL. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther 345(1):161-8, 2013. e-Pub 2013. PMID: 23386250.
113. Zhou HY, Chen SR, Byun HS, Chen H, Li L, Han HD, Lopez-Berestein G, Sood AK, Pan HL. NMDA Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl- Cotransporter-2 Disrupts Spinal Chloride Homeostasis in Neuropathic Pain. J Biol Chem 287(40):33853-64, 2012. e-Pub 2012. PMID: 22854961.
114. Zhao YL, Chen SR, Chen H, Pan HL. Chronic Opioid Potentiates Presynaptic but Impairs Postsynaptic N-Methyl-D-aspartic Acid Receptor Activity in Spinal Cords: IMPLICATIONS FOR OPIOID HYPERALGESIA AND TOLERANCE. J Biol Chem 287(30):25073-85, 2012. e-Pub 2012. PMID: 22679016.
115. Ye ZY, Li DP, Byun HS, Li L, Pan HL. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. J Neurosci 32(25):8560-8, 2012. e-Pub 2012. PMID: 22723696.
116. Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med 209(6):1121-34, 2012. e-Pub 2012. PMID: 22585736.
117. Cao XH, Chen SR, Li L, Pan HL. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem 121(6):944-53, 2012. e-Pub 2012. PMID: 22428625.
118. Ye ZY, Li L, Li DP, Pan HL. Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension. J Biol Chem 287(21):17438-46, 2012. e-Pub 2012. PMID: 22474321.
119. Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Up-regulation of Cavβ3 Subunit in Primary Sensory Neurons Increases Voltage-activated Ca2+ Channel Activity and Nociceptive Input in Neuropathic Pain. J Biol Chem 287(8):6002-13, 2012. e-Pub 2012. PMID: 22187436.
120. Li DP, Byan HS, Pan HL. Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. J Neurosci 32(1):372-80, 2012. e-Pub 2012. PMID: 22219297.
121. Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci U S A 109(1):101-6, 2012. e-Pub 2012. PMID: 22184224.
122. Su T, Cao F, Meng X, Pei L, Shi J, Pan HL, Li M. Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors. Eur J Pain 16:624-635, 2012. e-Pub 2012.
123. Cao XH, Byun HS, Chen SR, Pan HL. Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. J Neurochem 119(3):594-603, 2011. e-Pub 2011. PMID: 21883220.
124. Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric Oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem 286(38):33190-202, 2011. e-Pub 2011. PMID: 21813646.
125. Ye ZY, Li DP, Li L, Pan HL. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. J Neurosci 31(22):8271-9, 2011. e-Pub 2011. PMID: 21632948.
126. Chen SR, Chen H, Yuan WX, Pan HL. Increased presynaptic and postsynaptic a2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy. J Pharmacol Exp Ther 337(1):285-92, 2011. e-Pub 2011. PMID: 21248068.
127. Zhou HY, Chen SR, Chen H, Pan HL. Functional Plasticity of Group II Metabotropic Glutamate Receptors in Regulating Spinal Excitatory and Inhibitory Synaptic Input in Neuropathic Pain. J Pharmacol Exp Ther 336(1):254-64, 2011. e-Pub 2011. PMID: 20923868.
128. Su TF, Zhang LH, Peng M, Wu CH, Pan W, Tian B, Shi J, Pan HL, Li M. Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture. Mol Pain 7(98):98, 2011. e-Pub 2011. PMID: 22177137.
129. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem 285(52):40427-37, 2010. e-Pub 2010. PMID: 20940295.
130. Zhang J, Chen L, Su T, Cao F, Meng X, Pei L, Shi J, Pan HL, Li M. Electroacupuncture Increases CB2 Receptor Expression on Keratinocytes and Infiltrating Inflammatory Cells in Inflamed Skin Tissues of Rats. J Pain 11(12):1250-1258, 2010. e-Pub 2010. PMID: 20627823.
131. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem 114(5):1460-75, 2010. e-Pub 2010. PMID: 20557422.
132. Li DP, Pan HL. Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension. Am J Physiol Regul Integr Comp Physiol 299(2):R552-61, 2010. e-Pub 2010. PMID: 20519363.
133. Zhao J, Pan HL, Li TT, Zhang YQ, Wei JY, Zhao ZQ. The sensitization of peripheral C-fibers to lysophosphatidic acid in bone cancer pain. Life Sci 87(3-4):120-5, 2010. e-Pub 2010. PMID: 20553953.
134. Li DP, Chen SR, Pan HL. Adenosine inhibits paraventricular pre-sympathetic neurons through KATP-dependent potassium channels. J Neurochem 113(2):530-42, 2010. e-Pub 2010. PMID: 20096091.
135. Zhou HY, Chen SR, Chen H, Pan HL. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci 30(12):4460-6, 2010. e-Pub 2010. PMID: 20335482.
136. Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem 112(1):162-72, 2010. e-Pub 2010. PMID: 19840219.
137. Li DP, Pan HL. Role of GABAB receptors in autonomic control of systemic blood pressure. Adv Pharmacol 58:257-86, 2010. e-Pub 2010. PMID: 20655486.
138. Pan HL, Zhang YQ, Zhao ZQ. Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCe pathway in dorsal root ganglion neurons. Mol Pain 6:85, 2010. e-Pub 2010. PMID: 21118579.
139. Wu ZZ, Li DP, Chen SR, Pan HL. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem 284(52):36453-61, 2009. e-Pub 2009. PMID: 19850918.
140. Sun H, Li DP, Chen SR, Hittelman WN, Pan HL. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther 331(3):851-9, 2009. e-Pub 2009. PMID: 19726694.
141. Cai YQ, Chen SR, Han HD, Sood AK, Lopez-Berestein G, Pan HL. Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. J Neurochem 111(4):1000-10, 2009. e-Pub 2009. PMID: 19780895.
142. Chen SR, Samoriski G, Pan HL. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 57(2):121-6, 2009. e-Pub 2009. PMID: 19422840.
143. Chen L, Zhang J, Li F, Qiu Y, Wang L, Li YH, Shi J, Pan HL, Li M. Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. J Pain 10(7):732-9, 2009. e-Pub 2009. PMID: 19409856.
144. Chen SR, Cai YQ, Pan HL. Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. J Neurochem 110(1):352-62, 2009. e-Pub 2009. PMID: 19457113.
145. Wu ZZ, Cai YQ, Pan HL. A functional link between T-type calcium channels and mu-opioid receptor expression in adult primary sensory neurons. J Neurochem 109(3):867-78, 2009. e-Pub 2009. PMID: 19250340.
146. Yuan WX, Chen SR, Chen H, Pan HL. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience 158(4):1616-24, 2009. e-Pub 2009. PMID: 19068225.
147. Zhang HM, Chen SR, Cai YQ, Richardson TE, Driver LC, Lopez-Berestein G, Pan HL. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience 158(4):1577-88, 2009. e-Pub 2009. PMID: 19110040.
148. Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience 158(2):875-84, 2009. e-Pub 2009. PMID: 19017536.
149. Zhou HY, Chen SR, Chen H, Pan HL. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. J Neurochem 108(1):305-18, 2009. e-Pub 2009. PMID: 19012737.
150. Li DP, Yang Q, Pan HM, Pan HL. Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 295(2):H807-15, 2008. e-Pub 2008. PMID: 18567709.
151. Chen SR, Pan HL. Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception. Neuropharmacology 55(2):215-222, 2008. e-Pub 2008. PMID: 18579164.
152. Zhou HY, Chen SR, Chen H, Pan HL. Sustained Inhibition of Neurotransmitter Release from non-TRPV1-Expressing Primary Afferents by [D-Ala2,N-Me-Phe4,Gly-ol5]-Enkephalin in the Spinal Cord. J Pharmacol Exp Ther 327(2):375-82, 2008. e-Pub 2008. PMID: 18669865.
153. Wu ZZ, Chen SR, Pan HL. Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents. Neuroscience 153(4):1256-67, 2008. e-Pub 2008. PMID: 18434033.
154. Li DP, Yang Q, Pan HM, Pan HL. Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats. J Physiol 586(6):1637-47, 2008. e-Pub 2008. PMID: 18238817.
155. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. J Pharmacol Exp Ther 324(3):1000-10, 2008. e-Pub 2008. PMID: 18079355.
156. Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL. Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice. J Pharmacol Exp Ther 323(3):963-71, 2007. e-Pub 2007. PMID: 17878406.
157. Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience 149(2):315-27, 2007. e-Pub 2007. PMID: 17869444.
158. Wu ZZ, Pan HL. Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin. Am J Physiol Regul Integr Comp Physiol 293(1):R276-83, 2007. e-Pub 2007. PMID: 17491115.
159. Chen SR, Pan HM, Richardson TE, Pan HL. Potentiation of spinal alpha(2)-adrenoceptor analgesia in rats deficient in TRPV1-expressing afferent neurons. Neuropharmacology 52(8):1624-30, 2007. e-Pub 2007. PMID: 17482651.
160. Chen Q, Pan HL. Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. J Neurophysiol 97(5):3279-87, 2007. e-Pub 2007. PMID: 17287434.
161. Li DP, Pan HL. Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension. Hypertension 49(4):916-25, 2007. e-Pub 2007. PMID: 17309953.
162. Chen SR, Prunean A, Pan HM, Welker KL, Pan HL. Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons. Neuroscience 145(2):676-85, 2007. e-Pub 2007. PMID: 17239544.
163. Wang XL, Zhang HM, Chen SR, Pan HL. Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy. J Physiol 579(Pt 3):849-61, 2007. e-Pub 2007. PMID: 17218355.
164. Li DP, Pan HL. Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertension. J Pharmacol Exp Ther 320(2):615-26, 2007. e-Pub 2007. PMID: 17071818.
165. Zahner MR, Li DP, Pan HL. Benzodiazepine inhibits hypothalamic presympathetic neurons by potentiation of GABAergic synaptic input. Neuropharmacology 52(2):467-75, 2007. e-Pub 2007. PMID: 17045312.
166. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. J Neurophysiol 97(1):871-82, 2007. e-Pub 2007. PMID: 17108089.
167. Zhang HM, Chen SR, Pan HL. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. J Neurophysiol 97(1):102-9, 2007. e-Pub 2007. PMID: 17050831.
168. Chen Q, Pan HL. Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors. Neuroscience 142(2):595-606, 2006. e-Pub 2006. PMID: 16887273.
169. Wu ZZ, Chen SR, Pan HL. Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience 141(1):407-19, 2006. e-Pub 2006. PMID: 16678970.
170. Chen SR, Pan HL. Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol 95(5):3086-96, 2006. e-Pub 2006. PMID: 16467418.
171. Chen SR, Pan HL. Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids. Brain Res 1081(1):119-25, 2006. e-Pub 2006. PMID: 16499888.
172. Finnegan TF, Chen SR, Pan HL. Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels. J Neurophysiol 95(4):2032-41, 2006. e-Pub 2006. PMID: 16306173.
173. Wang XL, Zhang HM, Li DP, Chen SR, Pan HL. Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. J Physiol 571(Pt 2):403-13, 2006. e-Pub 2006. PMID: 16410279.
174. Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL. Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Mol Pharmacol 69(3):1048-55, 2006. e-Pub 2006. PMID: 16365281.
175. Li DP, Pan HL. Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension. Am J Physiol Heart Circ Physiol 290(3):H1110-9, 2006. e-Pub 2006. PMID: 16243912.
176. Chen Q, Li DP, Pan HL. Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons. J Pharmacol Exp Ther 316(2):733-42, 2006. e-Pub 2006. PMID: 16249372.
177. Chen YP, Chen SR, Pan HL. Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. J Pharmacol Exp Ther 315(2):696-703, 2005. e-Pub 2005. PMID: 16033910.
178. Chen YP, Chen SR, Pan HL. Systemic morphine inhibits dorsal horn projection neurons through spinal cholinergic system independent of descending pathways. J Pharmacol Exp Ther 314(2):611-617, 2005. e-Pub 2005. PMID: 15845859.
179. Vydyanathan A, Wu ZZ, Chen SR, Pan HL. A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol 93(6):3401-9, 2005. e-Pub 2005. PMID: 15647393.
180. Li DP, Pan HL. Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons. J Pharmacol Exp Ther 313(3):1035-45, 2005. e-Pub 2005. PMID: 15681656.
181. Wu ZZ, Chen SR, Pan HL. Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons. J Biol Chem 280(18):18142-18151, 2005. e-Pub 2005. PMID: 15746091.
182. Chen SR, Wess J, Pan HL. Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther 313(2):765-70, 2005. e-Pub 2005. PMID: 15665136.
183. Zhang HM, Li DP, Chen SR, Pan HL. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther 313(2):697-704, 2005. e-Pub 2005. PMID: 15640398.
184. Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res 1042(1):108-113, 2005. e-Pub 2005. PMID: 15823259.
185. Finnegan TF, Chen SR, Pan HL. Effect of the {mu} opioid on excitatory and inhibitory synaptic inputs to periaqueductal gray-projecting neurons in the amygdala. J Pharmacol Exp Ther 312(2):441-8, 2005. e-Pub 2005. PMID: 15388784.
186. Zahner MR, Pan HL. Role of paraventricular nucleus in the cardiogenic sympathetic reflex in rats. Am J Physiol Regul Integr Comp Physiol 288(2):R420-6, 2005. e-Pub 2005. PMID: 15472008.
187. Li DP, Atnip LM, Chen SR, Pan HL. Regulation of synaptic inputs to paraventricular-spinal output neurons by alpha2 adrenergic receptors. J Neurophysiol 93(1):393-402, 2005. e-Pub 2005. PMID: 15356178.
188. Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther 312(1):120-6, 2005. e-Pub 2005. PMID: 15375175.
189. Wu ZZ, Pan HL. Tetrodotoxin-sensitive and -resistant Na+ channel currents in subsets of small sensory neurons of rats. Brain Res 1029(2):251-8, 2004. e-Pub 2004. PMID: 15542080.
190. Wu ZZ, Chen SR, Pan HL. Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther 311(3):939-47, 2004. e-Pub 2004. PMID: 15280436.
191. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol, 2004. e-Pub 2004. PMID: 24081160.
192. Pan HL, Chen SR. Sensing tissue ischemia: another new function for capsaicin receptors?. Circulation 110(13):1826-31, 2004. e-Pub 2004. PMID: 15364816.
193. Wu ZZ, Pan HL. High voltage-activated Ca(2+) channel currents in isolectin B(4)-positive and -negative small dorsal root ganglion neurons of rats. Neurosci Lett 368(1):96-101, 2004. e-Pub 2004. PMID: 15342142.
194. Li DP, Chen SR, Pan HL. VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. J Neurophysiol 92(3):1807-1816, 2004. e-Pub 2004. PMID: 15115794.
195. Pan YZ, Pan HL. Primary afferent stimulation differentially potentiates excitatory and inhibitory inputs to spinal lamina II outer and inner neurons. J Neurophysiol 91(6):2413-21, 2004. e-Pub 2004. PMID: 14749303.
196. Finnegan TF, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. J Pharmacol Exp Ther 309(2):476-83, 2004. e-Pub 2004. PMID: 14724227.
197. Pan YZ, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors excites a population of locus coeruleus-spinal neurons through presynaptic disinhibition. Brain Res 997(1):67-78, 2004. e-Pub 2004. PMID: 14715151.
198. Li DP, Chen SR, Finnegan TF, Pan HL. Signaling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol 554(Pt 1):100-10, 2004. e-Pub 2004. PMID: 14678495.
199. Chen SR, Pan HL. Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. Neuroscience 125:141-148, 2004. e-Pub 2004.
200. Chen SR, Pan HL. Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology 99(6):1409-14, 2003. e-Pub 2003. PMID: 14639157.
201. Chen SR, Pan HL. Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther 307(2):676-81, 2003. e-Pub 2003. PMID: 12966147.
202. Zahner MR, Li DP, Chen SR, Pan HL. Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551(Pt 2):515-23, 2003. e-Pub 2003. PMID: 12829722.
203. Li DP, Chen SR, Pan HL. Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci 23(12):5041-9, 2003. e-Pub 2003. PMID: 12832527.
204. Li X, Conklin D, Pan HL, Eisenach JC. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther 305(3):950-5, 2003. e-Pub 2003. PMID: 12606636.
205. Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J Neurosci 23(7):2911-9, 2003. e-Pub 2003. PMID: 12684478.
206. Chen SR, Pan HL. Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. Brain Res 965(1-2):67-74, 2003. e-Pub 2003. PMID: 12591121.
207. Chen SR, Pan HL. Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats. Anesthesiology 98(1):217-22, 2003. e-Pub 2003. PMID: 12503000.
208. Chen SR, Pan HL. Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther 307:676-681, 2003. e-Pub 2003.
209. Chen SR, Sweigart KL, Lakoski JM, Pan HL. Functional mu opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology 97(6):1602-8, 2002. e-Pub 2002. PMID: 12459691.
210. Khan GM, Li DP, Chen SR, Pan HL. Role of spinal nitric oxide in the inhibitory effect of [D-Pen2, D-Pen5] -enkephalin on ascending dorsal horn neurons in normal and diabetic rats. J Pharmacol Exp Ther 303(3):1021-1028, 2002. e-Pub 2002. PMID: 12438523.
211. Pan YZ, Li DP, Chen SR, Pan HL. Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. J Neurophysiol 88(5):2675-83, 2002. e-Pub 2002. PMID: 12424303.
212. Li DP, Chen SR, Pan HL. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol 88(5):2664-74, 2002. e-Pub 2002. PMID: 12424302.
213. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol 543(Pt 3):807-18, 2002. e-Pub 2002. PMID: 12231640.
214. Chen SR, Pan HL. Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol 87(6):2726-2733, 2002. e-Pub 2002. PMID: 12037174.
215. Pan YZ, Li DP, Pan HL. Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic alpha(2)-adrenergic receptors. J Neurophysiol 87(4):1938-47, 2002. e-Pub 2002. PMID: 11929913.
216. Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain 96(1-2):13-22, 2002. e-Pub 2002. PMID: 11932057.
217. Pan HL, Chen SR. Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats. J Neurophysiol 87(2):8660-8668, 2002. e-Pub 2002. PMID: 11826035.
218. Chen SR, Wozniak KM, Slusher BS, Pan HL. Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. J Pharmacol Exp Ther 300(2):662-667, 2002. e-Pub 2002. PMID: 11805230.
219. Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathic pain in rats. Neuroscience 114:429-99, 2002. e-Pub 2002.
220. Li DP, Pan YZ, Pan HL. Acetylcholine attenuates synaptic GABA release to supraoptic neurons through presynaptic nicotinic receptors. Brain Res 920:151-158, 2001. e-Pub 2001.
221. Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology 95:1473-1479, 2001. e-Pub 2001.
222. Li DP, Pan HL. Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. Am J Physiol 281:R1105-R1113, 2001. e-Pub 2001.
223. Gokin AP, Fareed MU, Pan HL, Strichartz GR, Davar G. Endothelin-1 produces pain-like behavior an excitation of nociceptors in rats. J Neurosci 21:5358-5366, 2001. e-Pub 2001.
224. Chen SR, Pan HL. Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology 95:525-530, 2001. e-Pub 2001.
225. Chen SR, Khan GM, Pan HL. Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain. Anesthesiology 95:416-420, 2001. e-Pub 2001.
226. Pan HL, Xu Z, Leung E, Eisenach JC. Allosteric adenosine modulation to reduce allodynia. Anesthesiology 95:416-420, 2001. e-Pub 2001.
227. Li DP, Averill DB, Pan HL. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic relex. Am J Physiol 281:R376-84, 2001. e-Pub 2001.
228. Pan HL, Deal DD, Xu Z, Chen SR. Differential responses of regional sympathetic activity and blood flow to abdominal visceral afferent stimulation. Am J Physiol 280:R1781, 2001. e-Pub 2001.
229. Maher CE, Eisenach JC, Pan HL, Xiao R, Childers SR. Chronic intrathecal morphine produces homologous mu receptor/G-protein desensitization specially in spinal cord. Brain Res 895:1-8, 2001. e-Pub 2001.
230. Li DP, Pan HL. Responses of neurons in rostral ventrolateral medulla to activation of cardiac receptors in rats. AM J Physiolm Heart Circ Physiol 279(5):H2549-H2557, 2000. e-Pub 2000. PMID: 11045993.
231. Chen SR, Eisenach JC, Pan HL. Intrathecal SNAP and L -cysteine attenuate allodynia through noradrenergic activation in a rat model of neuropathic pain. Neuroscience 101:759-765, 2000. e-Pub 2000.
232. Li X, Rose G, Dongre N, Pan HL, Tobin JR, Eisenach JC. S-nitroso-L-cysteine releases norepinephrine in rat spinal cords. Brain Res 872:301-307, 2000. e-Pub 2000.
233. Chiari A, Li X, Pan HL, Eisenach JC. Formation of 6-nitro-norepinephrine from nitric oxide and norepinephrie in the spinal cord and its role in spinal analgesia. Neuroscience 101:189-196, 2000. e-Pub 2000.
234. Li X, Zhao Z, Pan HL, Eisenach JC. Norepinephrine release from spinal synaptosomes: Auto a 2-adrenergic receptor modulation. Anesthesiology 93:164-172, 2000. e-Pub 2000.
235. Pan HL, Chen SR, Scicli GM, Carretero OA. Cardiac Interstital bradydinin releasae during ischemia is enhanced by ischemia-preconditioning. Am J Physiol 279:H116-H121, 2000. e-Pub 2000.
236. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenasae-2 is involved in development of allodynia after nerve injury in rats. Neuroscience 97:743-748, 2000. e-Pub 2000.
237. Cheng JK, Pan HL, Eisenach JC. Antiallodynic effect of intrathecal gabapetin and its interaction with clonidine in a rat dodel of postoperative pain. Anesthesiology 92:1126-1131, 2000. e-Pub 2000.
238. Xu Z, Chen SR, Eisenach JC, Pan HL. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuroopathic pain. Brain Res 861:390-398, 2000. e-Pub 2000.
239. Li X, Rose G, Chiari A, Pan HL, Tobin JR, Eisenach JC. 6-No2-norepinephrine increases norepinephrine release and inhibits norepinephrine uptake in rat spinal synaptosomes. J Pharmacol Exp Ther 292:895-899, 2000. e-Pub 2000.
240. Chen SR, Eisenach JC, McCaslin P, Pan HL. Synergistic effect between intrathecal administration of non-NMDA receptor antagonist and gabapentin of experimental neuropathic pain. Anesthesiology 92:500-506, 2000. e-Pub 2000.
241. Chiari A, Tovin JR, Pan HL, Hood D, Eisenach JC. Sex difference in spinal analgesia: A supplemental nicotinic mechanism in females. Anesthesiology 91:1447-1454, 1999. e-Pub 1999.
242. Eisenach JC, Lavand'homme P, Cheng JK, Pan HL, Virtanen R, Nikkanen H, James R. Analgesic and hemodynamic effects of a novel a 2 adrenergic agonis, MVP 2426, in sheep. Anesthesiology 91:1425-1436, 1999. e-Pub 1999.
243. Pan HL, Longhurst JC, Eisenach JC, Chen SR. Role of protons in activation of cardiac sympathetic aferents during ischemia in cats. J Physiol (Lond) 518.3:857-866, 1999. e-Pub 1999.
244. Gomes JA, Li X, Pan HL, Eisenach JC. Intrathecal adenosine interacts with a spinal noradrenergic system to produce antiociception in nerve-injured rats. Anesthesiology 91:1072-1079, 1999. e-Pub 1999.
245. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 288:1026-1030, 1999. e-Pub 1999.
246. Pan HL, Chen SR, Eisenach JC. Intrathecal clonidine alleviates alllodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. Anesthesiology 90:509-514, 1999. e-Pub 1999.
247. Lavan'homme P, Pan HL, Eisenach JC. Intrathecal clonidine and neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain. Anesthesiology 89:493-499, 1998. e-Pub 1998.
248. Pan HL, Chen SR, Eisenach JC. Role of spinal nitric oxide in antiallodynic effect of intrathecal clonidine in neuropathic rats. Anesthesiology 89:1518-1523, 1998. e-Pub 1998.
249. Song H, Pan HL, Eisenach JC. Spinal nitric oxide mediates antinociception from IV morphine. Anesthesiology 89:215-221, 1998. e-Pub 1998.
250. Tjen-A-Looi S, Pan HL, Longhurst JC. Endogenous bradydinin actiates ischemically sensitive cardiac afferents through kinn B2 receptors. J Physiol (Lond) 510:633-641, 1998. e-Pub 1998.
251. Li P, Pisllides KF, Rendig SV, Pan HL, Longhurst JC. Reversal of reflex-induced myocardial ischemia by median nerve stimulation in cats. Circulation 97:1186-1194, 1998. e-Pub 1998.
252. Pan HL, Song H, Eisenach JC. Effects of itrathecal neostigmine and bupivacaine on the sympathetic efferent activity in rats. Anesthesiology 88:481-486, 1998. e-Pub 1998.
253. Fu LW, Pan HL, Longhurst JC. Endogenous histamine stimulates ischemically sensitive abdominal efferents through H1 receptors. Am J Physiol 273:H2726-H2737, 1997. e-Pub 1997.
254. Xu Z, Cerda SE, Pan HL, Eisenach JC. Intravenous morphine increases the release of nitric oxide from spinal cord by an a -adrenergic and cholinergic mechanism. J Neurophysiol 78:2072-2078, 1997. e-Pub 1997.
255. Pan HL, Zeisse ZB, Pitsllides KF, Longhurst JC. Spatiotemporal aspects of sympathetic C-fiber afferent activity in the pressor relex during abdominal ischemia. Am J Physiol 272:H1928-H1936, 1997. e-Pub 1997.
256. Pan HL, Zeisse ZB, Longhurst JC. Mechanical stimulation is not responsible for activation of gastrointestinal afferents during ischemia. Am J Physiol 272:H99-H106, 1997. e-Pub 1997.

Invited Articles

1. Huang, Y, Chen, S, Pan, H. α2δ-1-Linked NMDA and AMPA Receptors in Neuropathic Pain and Gabapentinoid Action. Journal of neurochemistry 169(4), 2025. e-Pub 2025. PMID: 40191897.
2. Santi, MD, Zhang, M, Liu, N, Viet, CT, Xie, T, Jensen, DD, Amit, M, Pan, H, Ye, Y. Repurposing EGFR Inhibitors for Oral Cancer Pain and Opioid Tolerance. Pharmaceuticals 16(11), 2023. e-Pub 2023. PMID: 38004424.
3. Wu T, Chen SR, Pan H, Luo Y. The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke. Front Neurol 14, 2023. e-Pub 2023. PMID: 37153659.
4. Huang, Y, Chen, S, Pan, H. Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmission at the Spinal Cord Level. Neuroscientist 28(6):628-638, 2022. e-Pub 2022. PMID: 34791930.
5. Ye, Y, Jensen, DD, Viet, CT, Pan, H, Campana, WM, Amit, M, Boada, MD. Advances in Head and Neck Cancer Pain. Journal of Dental Research 101(9):1025-1033, 2022. e-Pub 2022. PMID: 35416080.
6. Ghosh, K, Pan, H. Epigenetic Mechanisms of Neural Plasticity in Chronic Neuropathic Pain. ACS Chemical Neuroscience 13(4):432-441, 2022. e-Pub 2022. PMID: 35107991.
7. Deng M, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cellular and Molecular Life Sciences 76:1889-1899, 2019. e-Pub 2019.
8. Zhou ZZ, Ma H, Shao J, Pan HL, Li DP. Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension. Neurosci Bull 35(1):124-132, 2019. e-Pub 2019. PMID: 30506315.
9. Dampney RA, Michelini LC, Li DP, Pan HL. Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states. Am J Physiol Heart Circ Physiol 315(5), 2018. e-Pub 2018. PMID: 30095973.
10. Li DP, Pan HL. Glutamatergic Regulation of Hypothalamic Presympathetic Neurons in Hypertension. Curr Hyperten Rep 19(78), 2017. e-Pub 2017. PMID: 28929331.
11. Pan HL. How do pain receptors work? "Ask an Expert" series. Society for Neuroscience, 2013. e-Pub 2013.
12. Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol 4(3):379-388, 2011. e-Pub 2011. PMID: 21686074.
13. Li DP, Pan HL. Role of GABAb receptors in autonomic control of systemic blood pressure. GABAb Receptor Pharmacology: A Tribute to Norman Bowery 58C:257-286, 2010. e-Pub 2010.
14. Pan HL, Naguib M. Regulation of pain transmission by opioids and cannabinoids. Mechanisms of Pain in Peripheral Neuropathy:1-24, 2009. e-Pub 2009.
15. Pan HL, Wu ZZ, Zhou HY, Chen SR, Zhang HM, Li DP. Modulation of pain transmission by G protein-coupled receptors. Pharmacology & Therapeutics 117:141-161, 2008. e-Pub 2008. PMID: 17959251.
16. Pan HL, Dykes B. The changing role of GABAa receptors in regulation of pain transmission. Cell Science Reviews 5(2):150-158, 2008. e-Pub 2008.
17. Finnegan TF, Pan HL. An update on pharmacological actions of drugs for neuropathic pain treatment. J Neuropathic Pain Symp Palliation 1(3):19-34, 2006. e-Pub 2006.
18. Pan HL. Brain angiotensin II and synaptic transmission. Neuroscientist 10(5):422-431, 2004. e-Pub 2004. PMID: 15359009.

Other Articles

1. Carrillo E, Romero AM, Gonzalez CU, Turcu AL, Chen SR, Chen H, Pan H, Vasquez S, Twomey EC, Jayaraman V Memantine inhibits calcium permeable AMPA receptors. bioRxiv. PMID: 39005433.
2. Zhou, J, Luo, Y, Chen, S, Shao, JY, Sah, R, Pan, H Corrigendum to “LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons” [Experimental Neurology332 (2020) ,113391]. Experimental Neurology 349, 2022. PMID: 34965898.
3. Chen, J, Li, L, Chen, S, Chen, H, Xie, JD, Sirrieh, RE, MacLean, DM, Zhang, Y, Zhou, M, Jayaraman, V, Pan, H Erratum. Cell Reports 38(4), 2022. PMID: 35081351.

Editorials

1. Chen J, Pan HL. Dissecting Molecular Architecture of Postsynaptic Density at Excitatory Synapses. J Neurochem 142(4):500-503, 2017. PMID: 28741701.

Book Chapters

1. Hou S, Chen SR, Pan H. (Chapter 24) Gene therapy approaches to restore chloride homeostasis for treating neuropathic pain. In: Development of Therapies Targeting Neuronal Chloride Transporters. Elsevier Inc, 687-700, 2020.
2. Zhang, J, Pan H. (Chapter 4) Role of Histone Modifications in Chronic Pain Development. In: Epigenetics of Chronic Pain. 1. Elsevier Inc, 85-98, 2019.
3. Laumet G, Chen SR, Pan HL. The NMDA Receptors. In: NMDA Receptors and Signaling in Chronic Neuropathic Pain. Springer International Publishing AG-Humana Press, 103-119, 2017.
4. Bavencoffe A, Chen SR, Pan HL. In: Regulation of nociceptive transduction and transmission by nitric oxide. Elsevier Inc, 2013.
5. Alpay SN, Ozpolat B, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Delivering siRNA using nanoparticles to the central nervous system. In: Nanomedicine and the Nervous System. 12, 228-249, 2012.
6. Li DP, Pan HL. Role of GABAb receptors in autonomic control of systemic blood pressure. In: GABAb Receptor Pharmacology: ATribute to Norman Bowery. Adv Pharmacology, 228-249, 2010.
7. Pan HL, Naguib M. Regulation of pain tranmission by opioids and cannabinoids. In: Mechanisms of Pain in Peripheral Neuropathy, 1-24, 2009.

Letters to the Editor

1. Wu ZZ, Chen SR, Pan H. Reply to Meriney and Lacomis: Comment on direct aminopyridine effects on voltage-gated Ca2+ channels. J Biol Chem 293, 2018.
2. Ye ZY, Li DP, Pan HL. Response to glutamate receptors and presympathetic neuronal hyperactivity in the central nervous system of hypertension by Tsuda K. Hypertension, 2013.

Patents

1. Targeting a281-bound glutamate receptors for treating chronic pain and epilepsy, 2023. Patent Number: US11787839B2.
2. Stephan Gehrke, Pan H. Methods of Treating Pain Conditions and Compositions Related Thereto, 2023. Patent Number: US20230033299A1.