Ignacio I. Wistuba, M.D.
Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Professor and Chair, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, University of Texas Graduate School of Biomedical Sciences, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1985 | Austral University of Chile, Valdivia, CHL, MD, Medicine |
| 1983 | Austral University of Chile, Valdivia, CHL, Undergraduate, Medical School Undergraduate |
Postgraduate Training
| 1995-1999 | Postdoctoral, Molecular Pathology, Hamon Center for Therapeutic Oncology Research Center, UT Southwestern Medical Center, Dallas, TX |
| 1994-1995 | Postdoctoral, Pathology Research, UT Southwestern Medical Center & Simmons Cancer Center, Department of Pathology, Dallas, TX |
| 1986-1989 | Pathologist, Pathology, Catholic University of Chile, Santiago |
Board Certifications
| 1989 | Anatomic Pathology, Chile |
Experience & Service
Academic Appointments
Professor, Department of Pathology - Research, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2012
Associate Professor, Department of Pathology - Research, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2008
Associate Professor, Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center (joint appointment), Houston, TX, 2003 - 2008
Associate Professor, Department of Pathology, Catholic University of Chile, Santiago, 2002 - 2003
Instructor, Hamon Center for Therapeutic Oncology Research Center, UT Southwestern Medical Center, Dallas, TX, 1998 - 1999
Assistant Professor, Department of Pathology, Catholic University of Chile, Santiago, 1995 - 2002
Assistant Professor, Department of Pathology, University of La Frontera, Temuco, 1989 - 1995
Administrative Appointments/Responsibilities
Director of the UT-Lung SPORE Tissue Bank, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - Present
Other Appointments/Responsibilities
Lung Cancer Pathologist of the Lung Cancer Committee, Southwestern Oncology Group (SWOG), Ann Arbor, MI, 2009 - Present
Institutional Committee Activities
Member, MD Anderson Cancer Center Vice Provost Advisory Council on Clinical Research (VPAC-CR), 2012 - 2016
Pathology Liaison, MD Anderson Cancer Center Institute Personalized Advanced Cancer Therapy (IPCT), 2011 - 2018
Member, MD Anderson Cancer Center Sister Institution Network Fund (SINF) Committee, 2011 - 2012
Member, MD Anderson Cancer Center Southwestern Oncology Group (SWOG) Executive Committee, 2009 - Present
Member, MD Anderson Cancer Center Thoracic/Head and Neck Medical Oncology Trial Committee, 2004 - 2007
Endowed Positions
Anderson Clinical Faculty Chair for Cancer Treatment and Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - Present
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, Zhang J, Fujimoto J, Fowler J, Heymach JV, Dubinett S, Spira AE, Ehli EA, Wistuba II, Scheet P. Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer. Am J Respir Crit Care Med 200(6):742-750, 2019. PMID: 30896962.
- Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG, William WN, Zhang J, Lee J, Cascone T, Heymach JV, Forget MA, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II. Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer 6(1):48, 2018. e-Pub 2018. PMID: 29871672.
- Parra ER, Uraoka N, Jiang M, Cook P, Gibbons D, Forget MA, Bernatchez C, Haymaker C, Wistuba II, Rodriguez-Canales J. Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues. Sci Rep 7(1):13380, 2017. e-Pub 2017. PMID: 29042640.
- Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II. A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncol 3(8):1051-1058, 2017. e-Pub 2017. PMID: 28278348.
- Choi M, Kadara H, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Kim K, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Herbst RS, Wistuba II. Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function. Ann Oncol 28(1):83-89, 2017. PMID: 28177435.
- Kadara H, Choi M, Zhang J, Parra ER, Rodriguez-Canales J, Gaffney SG, Zhao Z, Behrens C, Fujimoto J, Chow C, Yoo Y, Kalhor N, Moran C, Rimm D, Swisher S, Gibbons DL, Heymach J, Kaftan E, Townsend JP, Lynch TJ, Schlessinger J, Lee J, Lifton RP, Wistuba II, Herbst RS. Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up. Ann Oncol 28(1):75-82, 2017. PMID: 31792518.
- Papadimitrakopoulou V, Lee JJ, Wistuba II, Tsao AS, Fossella FV, Kalhor N, Gupta S, Byers LA, Izzo JG, Gettinger SN, Goldberg SB, Tang X, Miller VA, Skoulidis F, Gibbons DL, Shen L, Wei C, Diao L, Peng SA, Wang J, Tam AL, Coombes KR, Koo JS, Mauro DJ, Rubin EH, Heymach JV, Hong WK, Herbst RS. The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer. J Clin Oncol. e-Pub 2016. PMID: 27480147.
- Zhang J, Fujimoto J, Zhang J, Wedge DC, Song X, Zhang J, Seth S, Chow CW, Cao Y, Gumbs C, Gold KA, Kalhor N, Little L, Mahadeshwar H, Moran C, Protopopov A, Sun H, Tang J, Wu X, Ye Y, William WN, Lee JJ, Heymach JV, Hong WK, Swisher S, Wistuba II, Futreal PA. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science 346(6206):256-9, 2014. PMID: 25301631.
- Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, Spira A, Coombes KR, Wistuba II. Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. J Natl Cancer Inst 106(3):dju004, 2014. e-Pub 2014. PMID: 24563515.
- Kim ES, Herbst RS, Wistuba I, Lee JJ, Blumenschein GR, Tsao A, Stewart DJ, Hicks ME, Erasmus J, Gupta S, Alden CM, Liu S, Tang X, Khuri FR, Tran HT, Johnson BE, Heymach JV, Mao L, Fossella F, Kies MS, Papadimitrakopoulou V, Davis SE, Lippman SM, Hong WK. The BATTLE Trial: Personalizing Therapy for Lung Cancer. Cancer Discov 1(1):44-53, 2011. e-Pub 2011. PMID: 22586319.
- Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6(2):244-85, 2011. PMID: 21252716.
- Tang X, Shigematsu H, Bekele BN, Roth JA, Minna JD, Hong WK, Gazdar AF, Wistuba II. EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res 65(17):7568-72, 2005. PMID: 16140919.
- Wistuba II, Behrens C, Milchgrub S, Virmani AK, Jagirdar J, Thomas B, Ioachim HL, Litzky LA, Brambilla EM, Minna JD, Gazdar AF. Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects. Jama 279(19):1554-9, 1998. PMID: 9605900.
- Wistuba II, Lam S, Behrens C, Virmani AK, Fong KM, LeRiche J, Samet JM, Srivastava S, Minna JD, Gazdar AF. Molecular damage in the bronchial epithelium of current and former smokers. J Natl Cancer Inst 89(18):1366-73, 1997. PMID: 9308707.
Grant & Contract Support
| Title: | Pathogenesis and Early Progression of Lung Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Defining and Defeating Mechanistic Subtypes of KRAS-Mutant Lung Cancers |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Core Leader |
| Title: | Pathology Core |
| Funding Source: | LCMC |
| Role: | Principal Investigator |
| Title: | Translational Genomics and Precision Medicine in Cancer Training Program |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | UT Southwestern Medical Center Lung SPORE |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Cancer Center Support Grant (CCSG) Tissue Procurement and Banking Core |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Translational Cancer Immune Monitoring and Analysis Center (TCIMAC) |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified September 13, 2024