Spatial biology with Dr. Jared Burks
What is spatial biology? See how different cell types in our tissues are interconnected.
Jared K. Burks, Ph.D.
Department of Leukemia, Division of Cancer Medicine
About Dr. Burks
I started my career in science as a research assistant in Dr. Max D. Summers’ laboratory. We studied protein trafficking in baculovirus-infected cells where I became familiar with, and interested in, spinning-disk confocal imaging. This led to my enrollment in several imaging courses, and ultimately my entry into graduate school and back to Dr. Summers’ laboratory. During my PhD training, Dr. Summers placed me in charge of the confocal microscope, where I trained every user and developed imaging assays as a basic core service. Ultimately, I ended up identifying importin-alpha-16, which is a shuttling protein involved in moving integral membrane proteins through the lateral channel of the nuclear pore complex. This was based in large part on my previous imaging experiments with BV/ODV E26, which was identified as a viral homolog to the eukaryotic importin-alpha-16. After completing my PhD, I joined Dr. Xing Li Wang’s group at Baylor, where I continued to study viral protein trafficking in infected cells. In doing so, I also learned how to interact with people from other cultures and how to collaborate on a larger scale. I also mastered extensive problem-solving skills that allowed me to determine where technical errors were made in our research efforts, which facilitated in my resolving them quickly and efficiently. I found that I enjoyed this type of technical problem solving, albeit I was not able to perform as much imaging work as I had anticipated. Therefore, after my postdoctoral work, I sought employment in a shared resource facility that specialized in imaging. I secured a position with the Flow Cytometry and Cellular Imaging Core Facility at MD Anderson Cancer Center where I have flourished. In fact, I am now an Associate Professor and Co-Director of the facility. I have brought eight color imaging to the Institution through the use of FFPE sampling and multispectral microscopy. I have also introduced and established mass cytometry, CyTOF, (imaging and suspension) to our Institution. The latest iteration of CyTOF technology is imaging-based. It uses laser ablation to free material from the slide for analysis through the CyTOF. My other focus is on live cell spinning disk confocal imaging. This has been a need for some time among MD Anderson Cancer Center researchers. Through my actions with these technologies I sought fund and was awarded an NIH R50 research specialist grant. I continue to focus on these technologies as we examine the spatial distribution of cells in tissues of the tumor microenvironment. I wish to understand the functional interactions that occur in unique spatial niche. My strengths have always been, and continue to be, that I am technically trained to identify, adapt, and utilize emerging technologies to answer critical questions in cutting-edge research here at MD Anderson Cancer Center and elsewhere in the scientific community. We tackle these problems every day at the Flow Cytometry and Cellular Imaging Core Facility at MD Anderson, and we jointly develop solutions with our research collaborators to produce outstanding scientific discoveries.
Present Title & Affiliation
Primary Appointment
Professor, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Flow Cytometry & Cell Imaging Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Spatial imaging
Mass Cytometry
Imaging Mass Cytometry
Live cell imaging
Confocal Imaging
Education & Training
Degree-Granting Education
| 2005 | Texas A&M University, College Station, TX, USA, PHD, Biology |
| 1995 | Florida Institute of Technology, Melbourne, FL, USA, BS, Molecular Biology |
| 1995 | Florida Institute of Technology, Melbourne, FL, USA, BS, Pre-Professional Biology |
Postgraduate Training
| 2006-2007 | Postdoctoral Associate, Baylor College of Medicine, Houston, TX |
Experience & Service
Other Appointments/Responsibilities
Associate Professor, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2021
Assistant Professor, The University of Texas MD Anderson Cancer Center ~ Department of Leukemia, Houston, TX, 2010 - 2018
Research Scientist, Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2010
Postdoctoral Associate, Baylor College of Medicine - Division of Cardiothoracic Surgery - Michael DeBakey Department of Surgery, Houston, TX, 2006 - 2007
Research Assistant, The Max D. Summers Laboratory, Department of Entomology, College Station, TX, 1995 - 1998
Necropsy Assistant, Arkansas Livestock and Poultry Pathology Laboratory, Little Rock, AR, 1993 - 1993
Laboratory Assistant, Medical Genetics Laboratory, Department of Biology, Melbourne, FL, 1990 - 1994
Institutional Committee Activities
Member, Digital Pathology Workforce, 2020 - Present
Member, Alternate Technologies for COVID Task Force, 2020 - Present
Committee Member, Basic Science/Laboratory Research Recovery Plan Committee, 2020 - 2020
Member, TMC3 Science Think Tank, 2020 - Present
Member, DIY PPE Task Force, 2020 - 2020
Committee Member, Research Storage Planning & Governance Committee, 2014 - Present
Member, SharePoint Advisory Team, 2013 - 2015
Member, Research IT Steering Committee, 2012 - 2013
Consultantships
Industry Advisory Board Member, University of Houston, Houston, Texas, 2020 - 2023
Honors & Awards
| 2004 | American Society of Virology, 2004 Annual Meeting, McGill University, Montreal, Canada |
| 2003 | Entomology Graduate Student Forum Presentation Award, Texas A&M University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Casso-Chapa B, Vazquez González NA, Le NT, Palaskas NL, Nead KT, Eutsey LP, Samanthapudi VSK, Osborn AM, Lee J, Mejia G, Hoang O, Lin SH, Deswal A, Herrmann J, Wang G, Kirkland JL, Krishnan S, Wehrens XHT, Chini EN, Yusuf SW, Iliescu CA, Jain A,Burks JK , Seeley E, Lorenzi PL, Chau KM, Ostos Mendoza KC, Grumbach IM, Brookes PS, Hanssen NMJ, de Winther MPJ, Yvan-Charvet L, Kotla S, Schadler K, Abe JI. Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease. Arterioscler Thromb Vasc Biol. e-Pub 2025. PMID: 39817327.
- Marques-Piubelli ML, Kumar B, Basar R, Panowski S, Srinivasan S, Norwood K, Prashad S, Szenes V, Balakumaran A, Arandhya A, Lu W, Khan K, Duenas D, McAllen S, Gomez JA, Burks JK , Acharyal S, Borthakur G, Wang WL, Wang W, Wang S, Solis LM, Marin D, Rezvani K, Daher M, Vega F. Increased Expression of CD70 in Relapsed Acute Myeloid Leukemia after Hypomethylating Agents. Virchows Arch 485(5):937-941, 2024. e-Pub 2024. PMID: 38388965.
- Sainz TP, Sahu V, Gomez JA, Dcunha NJ, Basi AV, Kettlun C, Sarami I, Burks JK , Sampath D, Vega F. Role of the Crosstalk B:Neoplastic T Follicular Helper Cells in the Pathobiology of Nodal T Follicular Helper Cell Lymphomas. Lab Invest 104(11):102147, 2024. e-Pub 2024. PMID: 39389311.
- Maksimovic S, Boscolo NC, La Posta L, Barrios S, Moussa MJ, Gentile E, Pesquera PI, Li W, Chen J, Gomez JA, Basi A, Burks JK, Alvarez-Breckenridge C, Gao J, Campbell MT, Dondossola E. Antiangiogenic tyrosine kinase inhibitors have differential efficacy in clear cell renal cell carcinoma in bone. Cancer Res Commun 4(10):2621-2637, 2024. e-Pub 2024. PMID: 39248577.
- Julienne Carstens et al. Spatial Multiplexing and Omics: a primer on the current state-of-the art technologies and applications. Nature Reviews Methods Primers, 2024. e-Pub 2024.
- Islam S, Gleber-Netto FO, Mulcahy CF, Glaun MDE, Srivastava S, Hunt PJ, Williams MD, Barbon CE, Spiotto M, Zhao W, Adebayo A, Akhter S, Xie T, Debnath KC, Sathishkumar HN, Myers B, Lothumalla S, Yaman I, Burks JK , Gomez J, Rao X, Wang J, Woodman K, Mansour J, Arenkiel B, Osman KL, Haxton C, Lever TE, Hutcheson KA, Amit M. Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma. Sci Transl Med 16(758):eabq5585, 2024. e-Pub 2024. PMID: 39083586.
- Hoke ATK, Takahashi Y, Padget MR, Gomez J, Amit M, Burks JK , Bell D, Xie T, Soon-Shiong P, Hodge JW, Hanna EY, London NR. Targeting Sinonasal Undifferentiated Carcinoma with a Combinatory Immunotherapy Approach. Transl Oncol 44:101943, 2024. e-Pub 2024. PMID: 38593586.
- Najem H, Pacheco S, Kowal J, Winkowski D, Burks JK , Heimberger AB. Protocol to quantify immune cell distribution from the vasculature to the glioma microenvironment on sequential immunofluorescence multiplex images. STAR Protoc 5(2):103079, 2024. e-Pub 2024. PMID: 38795354.
- Wang B, Reville PK, Yassouf MY, Jelloul FZ, Ly C, Desai PN, Wang Z, Borges P, Veletic I, Dasdemir E, Burks JK , Tang G, Guo S, Garza AI, Nasnas C, Vaughn NR, Baran N, Deng Q, Matthews J, Gunaratne PH, Antunes DA, Ekmekcioglu S, Sasaki K, Garcia MB, Cuglievan B, Hao D, Daver N, Green MR, Konopleva M, Futreal A, Post SM, Abbas HA. Comprehensive Characterization of IFNγ Signaling in Acute Myeloid Leukemia Reveals Prognostic and Therapeutic Strategies. Nat Commun 15(1):1821, 2024. e-Pub 2024. PMID: 38418901.
- Ferri-Borgogno S, Burks JK , Seeley EH, McKee TD, Stolley DL, Basi AV, Gomez JA, Gamal BT, Ayyadhury S, Lawson BC, Yates MS, Birrer MJ, Lu KH, Mok SC. Molecular, Metabolic, and Subcellular Mapping of the Tumor Immune Microenvironment via 3D Targeted and Non-Targeted Multiplex Multi-Omics Analyses. Cancers (Basel) 16(5), 2024. e-Pub 2024. PMID: 38473208.
- Zhao M, Wang T, Gleber-Netto FO, Chen Z, McGrail DJ, Gomez JA, Ju W, Gadhikar MA, Ma W, Shen L, Wang Q, Tang X, Pathak S, Raso MG, Burks JK , Lin SY, Wang J, Multani AS, Pickering CR, Chen J, Myers JN, Zhou G. Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response. Nat Commun 15(1):180, 2024. e-Pub 2024. PMID: 38167338.
- Zhang J, Dai H, Huo L, Burks JK , McGrail DJ, Lin SY. Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway. J Immunother Cancer 11(10), 2023. PMID: 37907220.
- Sousa LG, McGrail DJ, Lazar Neto F, Li K, Marques-Piubelli ML, Ferri-Borgogno S, Dai H, Mitani Y, Spardy Burr N, Cooper ZA, Kinneer K, Cortez MA, Lin SY, Bell D, El Naggar A, Burks JK , Ferrarotto R. Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors. Clin Cancer Res 29(16):3162-3171, 2023. e-Pub 2023. PMID: 37256648.
- Sans M, Makino Y, Min J, Rajapakshe KI, Yip-Schneider M, Schmidt CM, Hurd MW, Burks JK , Gomez JA, Thege FI, Fahrmann JF, Wolff RA, Kim MP, Guerrero PA, Maitra A. Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential. Cancer Discov 13(8):1844-1861, 2023. e-Pub 2023. PMID: 37285225.
- Baruch EN, Nagarajan P, Gleber-Netto FO, Rao X, Xie T, Akhter S, Adewale A, Shajedul I, Mattson BJ, Ferrarotto R, Wong MK, Davies MA, Jindal S, Basu S, Harwood C, Leigh I, Ajami N, Futreal A, Castillo M, Gunaratne P, Goepfert RP, Khushalani N, Wang J, Watowich S, Calin GA, Migden MR, Vermeer P, D'Silva N, Yaniv D, Burks JK , Gomez J, Dougherty PM, Tsai KY, Allison JP, Sharma P, Wargo J, Myers JN, Gross ND, Amit M. Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade. Res Sq, 2023. e-Pub 2023. PMID: 37503252.
- Desai PN, Wang B, Fonseca A, Borges P, Jelloul FZ, Reville PK, Lee E, Ly C, Basi A, Root J, Baran N, Post SM, Deng Q, Sun H, Harmanci AO, Burks JK , Gomez JA, DiNardo CD, Daver NG, Alatrash G, Konopleva M, Green MR, Antunes DA, Futreal A, Hao D, Abbas HA. Single-cell Profiling of CD8 T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion. Cancer Immunol Res:OF1-OF18. e-Pub 2023. PMID: 37285177.
- Jia Y, Zhang W, Basyal M, Chang KH, Ostermann L, Burks JK , Ly C, Mu-Mosley H, Zhang Q, Han X, Fogler WE, Magnani JL, Lesegretain A, Zal AA, Zal T, Andreeff M. FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML. Leukemia 37(6):1379-1383, 2023. e-Pub 2023. PMID: 37085610.
- Abe JI, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Bojorges AP, Gi YJ, Hobbs BP, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen TH, Gupte AA, Reyes-Gibby C, Yeung SJ, Abe RJ, Olmsted-Davis EA, Krishnan S, Dantzer R, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK , Wang G, Le NT, Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circ Res 133(1):25-44, 2023. e-Pub 2023. PMID: 37264926.
- Pourebrahim R, Heinz Montoya R, Alaniz Z, Ostermann L, Lin PP, Liu B, Ayoub E, Burks JK , Andreeff M. Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage. Cell Death Dis 14(6):371, 2023. e-Pub 2023. PMID: 37353528.
- Ferri-Borgogno S, Zhu Y, Sheng J, Burks JK , Gomez JA, Wong KK, Wong STC, Mok SC. Spatial transcriptomics depict ligand-receptor crosstalk heterogeneity at the tumor-stroma interface in long-term ovarian cancer survivors. Cancer Res 83(9):1503-1516, 2023. e-Pub 2023. PMID: 36787106.
- Pourebrahim R, Montoya RH, Alaniz Z, Ostermann L, Lin PP, Liu B, Ayoub E, Burks JK, Andreeff M. Mdm2/p53 levels in bone marrow mesenchymal stromal cells is essential for maintaining the hematopoietic niche in response to DNA damage. Res Sq, 2023. e-Pub 2023. PMID: 36909480.
- Yasunari Fukuda, Sun-Hee Kim, Matias Bustos, Sung-Nam Cho, Jason Roszik, Burks JK, Hong Kim, Dave Hoon, Elizabeth Grimm, and Suhendan Ekmekcioglu. Inhibition of microsomal prostaglandin E2 synthase has a potential to improve immunotherapy by reducing collagen deposition and T cell exhaustion in melanoma. Cancer Research Communications, 2023. PMID: 37529399.
- Kang Y, Deng J, Ling J, Li X, Chiang YJ, Koay EJ, Wang H, Burks JK, Chiao PJ, Hurd MW, Bhutani MS, Lee JH, Weston BR, Maitra A, Ikoma N, Tzeng CD, Lee JE, DePinho RA, Wolff RA, Pant S, McAllister F, Katz MH, Fleming JB, Kim MP. 3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma. J Clin Invest 132(24), 2022. e-Pub 2022. PMID: 36282600.
- Wang X, Semba T, Manyam GC, Wang J, Shao S, Bertucci F, Finetti P, Krishnamurthy S, Phi LTH, Pearson T, Van Laere SJ, Burks JK, Cohen EN, Reuben JM, Yang F, Min H, Navin N, Trinh VN, Iwase T, Batra H, Shen Y, Zhang X, Tripathy D, Ueno NT. EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer. Sci Adv 8(50):eabn7983, 2022. e-Pub 2022. PMID: 36525493.
- Radnaa E, Richardson L, Goldman B, Burks JK, Baljinnyam T, Vora N, Zhang HJ, Bonney EA, Han A, Menon R. Stress Signaler p38 Mitogen-Activated Kinase Activation: A Cause for Concern?. Clin Sci (Lond) 136(22):1591-1614, 2022. PMID: 36250628.
- Amit M, Xie T, Gleber-Netto FO, Hunt PJ, Mehta GU, Bell D, Silverman DA, Yaman I, Ye Y, Burks JK, Fuller GN, Gidley PW, Nader ME, Raza SM, DeMonte F. Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology. J Exp Clin Cancer Res 41(1):292, 2022. e-Pub 2022. PMID: 36195959.
- Yared Hailemichael, Daniel H. Johnson, Noha Abdel-Wahab, Wai Chin Foo, May Daher, Cara Haymaker, Khalida M. Wani, Chantal M. Saberian, Dai Ogata, Salah Eddine Bentebibel, Sang Taek Kim, Roza Nurieva, Alexander Lazar, Hamzah Abu-Sbeih, Yinghong Wang, Van Anh Trinh, Chrystia M. Zobniw, Christine A. Spillson, Burks JK, Luisa Solis, Alejandro Francisco Cruz, Mario Luiz Marques-Piubelli, Wei Lu, Brenda Denisse Melendez, Michael A. Davies, Jennifer Wargo, Jonathan L. Curry, Gregory A. Lizee, Cassian Yee, Patrick Hwu, Suhendan Ekmekcioglu, Adi Diab. Interleukin-6 blockade abrogates CTLA-4 blockade immune toxicity and promotes antitumor immunity. Cancer Cell 40(5):509-523. e6. e-Pub 2022.
- Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A, Krishnan SN, Varn FS, Arrieta VA, Gupta P, Ferguson SD, Huse JT, Fuller GN, Long JP, Winkowski DE, Freiberg BA, James CD, Platanias LC, Lesniak MS, Burks JK, Heimberger AB. Central nervous system immune interactome is function of cancer lineage, tumor microenvironment and STAT3 expression. JCI Insight 7(9), 2022. e-Pub 2022. PMID: 35316217.
- Fukuda Y, Bustos MA, Cho SN, Roszik J, Ryu S, Lopez VM, Burks JK , Lee JE, Grimm EA, Hoon DSB, Ekmekcioglu S. Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma. Cell Death Dis 13(5):422, 2022. e-Pub 2022. PMID: 35501311.
- Millian DE, Saldarriaga OA, Wanninger T, Burks JK, Rafati YN, Gosnell J, Stevenson HL. Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment-Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma. Cancers (Basel) 14(8), 2022. e-Pub 2022. PMID: 35454766.
- Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C, Shilati J, Jaishankar D, Chen L, Gould A, Zhang D, Yuan J, Zhao W, Ling X, Burks JK , Laffleur B, Amidei C, Bruce JN, Lukas RV, Yamaguchi JT, Cieremans D, Rothschild G, Basu U, McCord M, Brat DJ, Zhang H, Cooper LAD, Zhang B, Sims P, Cloughesy TF, Prins R, Canoll P, Stupp R, Heimberger AB, Horbinski C, Iwamoto FM, Rabadan R, Sonabend AM. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer 3(3):373, 2022. PMID: 35149861.
- Sousa LG, McGrail DJ, Li K, Marques-Piubelli ML, Gonzalez C, Dai H, Ferri-Borgogno S, Godoy M, Burks JK, Lin SY, Bell D, Ferrarotto R. Spontaneous tumor regression following COVID-19 vaccination. J Immunother Cancer 10(3), 2022. PMID: 35241495.
- Fukuda Y, Bustos MA, Cho SN, Roszik J, Ryu S, Lopez VM, Burks JK , Lee JE, Grimm EA, Hoon DSB, Ekmekcioglu S. Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma. Cell Death Dis 13(2):117, 2022. e-Pub 2022. PMID: 35121729.
- Quesada PR, Riquelme E, Burks JK, Rakoski A, Sahin I, McAllister F. Assessment of the Murine Tumor Microenvironment by Multiplex Immunofluorescence. Methods Mol Biol 2435:107-127, 2022. PMID: 34993942.
- Imanishi M, Cheng H, Kotla S, Deswal A, Le NT, Chini E, Ko KA, Samanthapudi VSK, Lee LL, Herrmann J, Xu X, Reyes-Gibby C, Yeung SJ, Schadler KL, Yusuf SW, Liao Z, Nurieva R, Amir ED, Burks JK, Palaskas NL, Cooke JP, Lin SH, Kobayashi M, Yoshimoto M, Abe JI. Radiation therapy induces immunosenescence mediated by p90RSK. Front Cardiovasc Med 9:988713, 2022. e-Pub 2022. PMID: 36426217.
- Corvigno S, Burks JK, Hu W, Zhong Y, Jennings NB, Fleming ND, Westin SN, Fellman B, Liu J, Sood AK. Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status. J Cancer Res Clin Oncol 147(12):3545-3555, 2021. e-Pub 2021. PMID: 34476576.
- Arrieta VA, Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C, Shilati J, Jaishankar D, Chen L, Gould A, Zhang D, Yuan J, Zhao W, Ling X, Burks JK, Laffleur B, Amidei C, Bruce JN, Lukas RV, Yamaguchi JT, Cieremans D, Rothschild G, Basu U, McCord M, Brat DJ, Zhang H, Cooper LAD, Zhang B, Sims P, Cloughesy TF, Prins R, Canoll P, Stupp R, Heimberger AB, Horbinski C, Iwamoto FM, Rabadan R, Sonabend AM. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer 2(12):1372-1386, 2021. e-Pub 2021. PMID: 35121903.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo- radiation. Redox Biol 7:102132, 2021. e-Pub 2021. PMID: 34619528.
- Muftuoglu M, Li L, Liang S, Mak D, Lin AJ, Fang J, Burks JK, Chen K, Andreeff M. Extended Live-cell Barcoding Approach for Multiplexed Mass Cytometry. Sci Rep 11(1):12388, 2021. e-Pub 2021. PMID: 34117319.
- Bommi PV, Bowen CM, Reyes-Uribe L, Wu W, Katayama H, Rocha P, Parra ER, Francisco-Cruz A, Ozcan Z, Tosti E, Willis JA, Wu H, Taggart MW, Burks JK, Lynch PM, Edelmann W, Scheet PA, Wistuba II, Sinha KM, Hanash SM, Vilar E. The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells. Cancer Res 81(10):2760-2773, 2021. e-Pub 2021. PMID: 34003775.
- Carstens JL, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews KM, Rao A, Burks JK, Rhim AD, Kalluri R. Stabilized Epithelial Phenotype of Cancer Cells in Primary Tumors Leads to Increased Colonization of Liver Metastasis in Pancreatic Cancer. Cell Rep 35(2):108990, 2021. PMID: 33852841.
- Zhu Y, Ferri-Borgogno S, Sheng J, Yeung TL, Burks JK, Cappello P, Jazaeri AA, Kim JH, Han GH, Birrer MJ, Mok SC, Wong STC. SIO: A Spatioimageomics Pipeline to Identify Prognostic Biomarkers Associated with the Ovarian Tumor Microenvironment. Cancers (Basel) 13(8), 2021. e-Pub 2021. PMID: 33917869.
- Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V. Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Haematologica 106(2):495-512, 2021. e-Pub 2021. PMID: 32029507.
- Najem H, Marisetty A, Horbinski C, Long J, Huse JT, Glitza Oliva IC, Ferguson SD, Kumthekar PU, Wainwright DA, Chen P, Lesniak MS, Burks JK, Heimberger AB. CD11c+CD163+ Cells and Signal Transducer and Activator of Transcription 3 (STAT3) Expression Are Common in Melanoma Leptomeningeal Disease. Frontiers in immunology 12:4209, 2021. e-Pub 2021. PMID: 34691054.
- Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks JK, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya P, McAllister F. Interleukin 17 induced- neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217(12), 2020. PMID: 32860704.
- Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling. Gastroenterology 159(6):2146-2162.e33, 2020. e-Pub 2020. PMID: 32805281.
- Ott M, Kassab C, Marisetty A, Hashimoto Y, Wei J, Zamler D, Leu JS, Tomaszowski KH, Sabbagh A, Fang D, Gupta P, Priebe W, Zielinski RJ, Burks JK, Long JP, Kong LY, Fuller GN, DeGroot J, Sulman EP, Heimberger AB. Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy. Clin Cancer Res 26(18):4983-4994, 2020. e-Pub 2020. PMID: 32605912.
- Batth IS, Meng Q, Wang Q, Torres KE, Burks JK, Wang J, Gorlick R, Li S. Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis. BMC Cancer 20(1):715, 2020. e-Pub 2020. PMID: 32736533.
- Saldarriaga OA, Freiberg B, Krishnan S, Rao A, Burks JK, Booth AL, Dye B, Utay N, Ferguson M, Akil A, Yi M, Beretta L, Stevenson HL. Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease. Hepatol Commun 4(5):708-723, 2020. e-Pub 2020. PMID: 32363321.
- Lee S, Zhao L, Rojas C, Bateman NW, Yao H, Lara OD, Celestino J, Morgan MB, Nguyen TV, Conrads KA, Rangel KM, Dood RL, Hajek RA, Fawcett GL, Chu RA, Wilson K, Loffredo JL, Viollet C, Jazaeri AA, Dalgard CL, Mao X, Song X, Zhou M, Hood BL, Banskota N, Wilkerson MD, Te J, Soltis AR, Roman K, Dunn A, Cordover D, Eterovic AK, Liu J, Burks JK, Baggerly KA, Fleming ND, Lu KH, Westin SN, Coleman RL, Mills GB, Casablanca Y, Zhang J, Conrads TP, Maxwell GL, Futreal PA, Sood AK. Molecular analysis of clinically defined subsets of high-grade serous ovarian cancer. Cell Rep 31(2):107502, 2020. PMID: 32294438.
- Han L, Zhang Q, Dail M, Shi C, Cavazos A, Ruvolo VR, Zhao Y, Kim E, Rahmani M, Mak DH, Jin SS, Chen J, Phillips DC, Koller PB, Jacamo R, Burks JK, DiNardo C, Daver N, Jabbour E, Wang J, Kantarjian HM, Andreeff M, Grant S, Leverson JD, Sampath D, Konopleva M. Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models. Haematologica 105(3):697-707, 2020. e-Pub 2019. PMID: 31123034.
- Burks JK. Going Beyond Sight, Revealing Multiplex Biology. Journal of Pathology Informatics, 2020.
- Yokoi A, Villar-Prados A, Oliphint PA, Zhang J, Song X, De Hoff P, Morey R, Liu J, Roszik J, Clise-Dwyer K, Burks JK, O'Halloran TJ, Laurent LC, Sood AK. Mechanisms of nuclear content loading to exosomes. Sci Adv 5(11):eaax8849, 2019. PMID: 31799396.
- Lara OD, Krishnan S, Wang Z, Corvigno S, Zhong Y, Lyons Y, Dood R, Hu W, Qi L, Liu J, Coleman RL, Westin SN, Fleming ND, Cristini V, Rao A, Burks JK, Sood AK. Tumor core biopsies adequately represent immune microenvironment of high-grade serous carcinoma. Sci Rep 9(1):17589, 2019. e-Pub 2019. PMID: 31772388.
- Chattopadhyay C, Oba J, Roszik J, Marszalek JR, Chen K, Qi Y, Eterovic K, Robertson AG, Burks JK, McCannel TA, Grimm EA, Woodman SE. Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma. Invest Ophthalmol Vis Sci 60(13):4187-4195, 2019. PMID: 31596927.
- Kannan S, Aitken MJL, Herbrich SM, Golfman LS, Hall MG, Mak DH, Burks JK, Song G, Konopleva M, Mullighan CG, Chandra J, Zweidler-McKay PA. Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther 18(9):1615-1627, 2019. PMID: 31227645.
- Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell 178(4):795-806.e12, 2019. PMID: 31398337.
- Carter BZ, Mak PY, Wang X, Tao W, Ruvolo V, Mak D, Mu H, Burks JK, Andreeff M. An ARC-regulated IL1β/Cox-2/PGE2/β-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML. Cancer Res 79(6):1165-1177, 2019. e-Pub 2019. PMID: 30674535.
- Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape. Oncoimmunology 8(4):e1568809, 2019. e-Pub 2019. PMID: 30906661.
- Cynthia Kassab, Jonathan Levine, Beth Boudreau, Xiaoyang Ling, Burks JK, Shouhao Zhou, Roel Verhaak, Amy Heimberger. IMMU-36. IMMUNE RESPONSES IN CANINE GLIOMAS ARE ENRICHED AT THE INFILTRATING EDGE OF ASTROCYTOMAS. Neuro-oncology 20, 2018.
- Reddy JP, Atkinson RL, Larson R, Burks JK, Smith D, Debeb BG, Ruffell B, Creighton CJ, Bambhroliya A, Reuben JM, Van Laere SJ, Krishnamurthy S, Symmans WF, Brewster AM, Woodward WA. Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Res Treat 171(2):283-293, 2018. e-Pub 2018. PMID: 29858753.
- Ruvolo PP, Ruvolo VR, Burks JK, Qiu Y, Wang RY, Shpall EJ, Mirandola L, Hail N, Zeng Z, McQueen T, Daver N, Post SM, Chiriva-Internati M, Kornblau SM, Andreeff M. Role of MSC-derived galectin 3 in the AML microenvironment. Biochim Biophys Acta Mol Cell Res 1865(7):959-969, 2018. e-Pub 2018. PMID: 29655803.
- Jiang X, Mak PY, Mu H, Tao W, Mak DH, Kornblau S, Zhang Q, Ruvolo P, Burks JK, Zhang W, McQueen T, Pan R, Zhou H, Konopleva M, Cortes J, Liu Q, Andreeff M, Carter BZ. Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition inFLT3-Mutant Acute Myeloid Leukemia. Clin Cancer Res 24(10):2417-2429, 2018. e-Pub 2018. PMID: 29463558.
- McCarthy RL, Mak DH, Burks JK, Barton MC. Rapid monoisotopic cisplatin based barcoding for multiplexed mass cytometry. Sci Rep 7(1):3779, 2017. e-Pub 2017. PMID: 28630464.
- Liu S, Anfossi S, Qiu B, Zheng Y, Cai M, Fu J, Yang H, Liu Q, Chen Z, Fu J, Liu M, Burks JK, Lin SH, Reuben J, Liu H. Prognostic Factors for Locoregional Recurrence in Patients with Thoracic Esophageal Squamous Cell Carcinoma Treated with Radical Two-Field Lymph Node Dissection: Results from Long-Term Follow-Up. Ann Surg Oncol 24(4):966-973, 2017. e-Pub 2016. PMID: 27804027.
- Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, Joo J, Kim SC, Yun JS, Na KJ, Choi YL, Park JL, Kim SY, Lee YS, Han L, Liang H, Mak D, Burks JK, Zo JI, Sugarbaker DJ, Shim YM, Lee JS. Integrated Genomic Analysis of Recurrence-Associated Small Non-coding RNAs in Oesophageal Cancer. Gut 66(2):215-225, 2017. e-Pub 2016. PMID: 27507904.
- Mansfield JR, Guest PC,Burks JK. Phenotyping Multiple Subsets of Immune Cells In Situ in Formalin-Fixed, Paraffin-Embedded Tissue Sections. Adv Exp Med Biol 974:327-338, 2017. PMID: 28353253.
- Ruvolo PP, Ruvolo VR, Benton CB, AlRawi A, Burks JK, Schober W, Rolke J, Tidmarsh G, Hail N, Davis RE, Andreeff M. Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells. Biochim Biophys Acta 1863(4):562-71, 2016. e-Pub 2015. PMID: 26704388.
- Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M. Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network. Oncotarget 7(15):20054-67, 2016. PMID: 26956049.
- Nduom EK, Wei J, Yaghi NK, Huang N, Kong LY, Gabrusiewicz K, Ling X, Zhou S, Ivan C, Chen JQ, Burks JK, Fuller GN, Calin GA, Conrad CA, Creasy C, Ritthipichai K, Radvanyi L, Heimberger AB. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol 18(2):195-205, 2016. e-Pub 2015. PMID: 26323609.
- Han L, Qiu P, Zeng Z, Jorgensen JL, Mak DH, Burks JK, Schober W, McQueen TJ, Cortes J, Tanner SD, Roboz GJ, Kantarjian HM, Kornblau SM, Guzman ML, Andreeff M, Konopleva M. Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry A 87(4):346-56, 2015. e-Pub 2015. PMID: 25598437.
- Zhang Y, Nowicka A, Solley TN, Wei C, Parikh A, Court L, Burks JK, Andreeff M, Woodward WA, Dadbin A, Kolonin MG, Lu KH, Klopp AH. Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers. PLoS One 10(8):e0136361, 2015. e-Pub 2015. PMID: 26317219.
- Ruvolo PP, Ruvolo VR, Benton C, Burks JK, Schober W, Rolke J, Tidmarsh G, Hail N, Davis E, Andreeff M. Galectin inhibitor GCS-100 synergizes with BH3 mimetics to eliminate AML cells and sensitizes AML cells to KPT-185 be a mechanism involving suppression of XPO1. Biochim Biophys Acta, 2015.
- Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks JK, Jacamo R, Kojima K, Ruvolo P, Fueyo-Margareto J, Konopleva M, Andreeff M. MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. PLoS One 10(10):e0139254, 2015. e-Pub 2015. PMID: 26440941.
- Ruvolo PP, Ruvolo VR, Jacamo R, Burks JK, Zeng Z, Duvvuri SR, Zhou L, Qiu Y, Coombes KR, Zhang N, Yoo SY, Pan R, Hail N, Konopleva M, Calin G, Kornblau SM, Andreeff M. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Biochim Biophys Acta 1843(9):1969-77, 2014. e-Pub 2014. PMID: 24858343.
- Mak PY, Mak DH, Mu H, Shi Y, Ruvolo P, Ruvolo V, Jacamo R, Burks JK, Wei W, Huang X, Kornblau SM, Andreeff M, Carter BZ. Apoptosis Repressor with Caspase Recruitment Domain Is Regulated by MAPK/PI3K and Confers Drug Resistance and Survival Advantage to AML. Apoptosis 19(4):698-707, 2014. e-Pub 2013. PMID: 24337870.
- Kojima K, Kornblau SM, Ruvolo V, Dilip A, Duvvuri S, Davis RE, Zhang M, Wang Z, Coombes KR, Zhang N, Qiu YH, Burks JK, Kantarjian H, Shacham S, Kauffman M, Andreeff M. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood 121(20):4166-74, 2013. e-Pub 2013. PMID: 23564911.
- Shah N, Martin-Antonio B, Yang H, Ku S, Lee DA, Cooper LJ, Decker WK, Li S, Robinson SN, Sekine T, Parmar S, Gribben J, Wang M, Rezvani K, Yvon E, Najjar A, Burks JK, Kaur I, Champlin RE, Bollard CM, Shpall EJ. Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity. PLoS One 8(10):1-9, 2013. e-Pub 2013. PMID: 24204673.
- Mazurek N, Byrd JC, Sun Y, Hafley M, Ramirez K, Burks JK, Bresalier RS. Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ 19(3):523-33, 2012. e-Pub 2011. PMID: 21941373.
- Kidd S, Spaeth E, Watson K, Burks JK, Lu H, Klopp A, Andreeff M, Marini FC. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7(2):e30563, 2012. e-Pub 2012. PMID: 22363446.
- Ruvolo PP, Zhou L, Watt JC, Ruvolo VR, Burks JK, Jiffar T, Kornblau S, Konopleva M, Andreeff M. Targeting PKC Mediated Signal Transduction Pathways Using Enzastaurin to Promote Apoptosis in Acute Myeloid Leukemia-derived Cell Lines and Blast Cells. J Cell Biochem 112(6):1696-707, 2011. e-Pub 2011. PMID: 21360576.
- Kojima K, Burks JK, Arts J, Andreeff M. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther 9(9):2545-57, 2010. e-Pub 2010. PMID: 20736344.
- Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM. Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother 33(7):684-96, 2010. PMID: 20664358.
- Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70(6):2424-34, 2010. e-Pub 2010. PMID: 20215498.
- Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks JK, Clise-Dwyer K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-ß Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron 3(1):83-95, 2010. e-Pub 2010. PMID: 21209776.
- Serda RE, Gu J, Burks JK, Ferrari K, Ferrari C, Ferrari M. Quantitative mechanics of endothelial phagocytosis of silicon microparticles. Cytometry A 75(9):752-60, 2009. PMID: 19610127.
- Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 113(7):1504-12, 2009. e-Pub 2008. PMID: 18957686.
- Zhang C, Zhang MX, Shen YH, Burks JK, Li XN, LeMaire SA, Yoshimura K, Aoki H, Matsuzaki M, An FS, Engler DA, Matsunami RK, Coselli JS, Zhang Y, Wang XL. Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. Biochim Biophys Acta 1783(8):1517-28, 2008. e-Pub 2008. PMID: 18439917.
- Zhang C, Zhang MX, Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol 27(8):1760-7, 2007. e-Pub 2007. PMID: 17478756.
- Burks JK, Summers MD, Braunagel SC. BV/ODV-E26: a palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus. Virology 361(1):194-203, 2007. e-Pub 2006. PMID: 17169392.
- Saksena S, Summers MD, Burks JK, Johnson AE, Braunagel SC. Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol 13(6):500-8, 2006. e-Pub 2006. PMID: 16715095.
- Braunagel SC, Burks JK , Rosas-Acosta G, Harrison RL, Ma H, Summers MD. Mutations within the Autographa californica nucleopolyhedrovirus FP25K gene decrease the accumulation of ODV-E66 and alter its intranuclear transport. J Virol 73(10):8559-70, 1999. PMID: 10482609.
Invited Articles
- Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gumin J, Nwajei F, Rezavanian A, Zhou S, Rao G, Sawaya R, Fuller GN, Huse JT, Antel JP, Li S, Cooper L, Sulman EP, Chen C, Geula C, Kalluri R, Zal T, Heimberger AB. Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. Oncoimmunology 7(4):e1412909, 2018. e-Pub 2018. PMID: 29632728.
Other Articles
- Omar A Saldarriaga, Adam L Booth, Benjamin Freiberg, Burks JK, Santhoshi Krishnan, Arvind Rao, Netanya Utay, Monique Ferguson, Minkyung Yi, Laura Beretta, Heather L Stevenson Multispectral imaging differentiates unique macrophage profiles in patients with distinct chronic liver diseases. bioRxiv:794610, 2019.
- Andreeff M, Zeng Z, Tabe Y, Samudio I, Fiegl M, Watt J, Dietrich, M., McQueen T, Frolova O, Battula L, Mnjoyan Z, Shi Y-X, Konoplev S, Burks JK, Konopleva M Microenvironment and leukemia: Yin and yang. Ann Hematol Suppl:1: S94-S98, 2008.
Abstracts
- Reuben JM & Wang X, ManyamGC, ; Wang J, Shao SH, Bertucci, Finetti P, Krishnamurthy S, Phi T, Hanh L, Pearson T, Burks JK, Cohen,EN, Hu M, Navin N, Shen Y, Zhang X, Tripathy D, Ueno NT. Remodeling the inflammatory breast cancer tumor microenvironment to enhance immunotherapy: Novel therapeutic development. AACR 2021, 2022.
- Hinda Najem et al. The central nervous system immune cell interactome is a function of cancer lineage, tumor microenvironment and STAT3 expression. AACR Annual Meeting 2022, 2022.
- Luana Guimaraes de Sousa et al. Single-Cell Immune Mapping of Adenoid Cystic Carcinoma (ACC) Reveals Potential Therapeutic Targets for the aggressive Solid subtype. 2022 ASCO Annual Meeting, 2022.
- Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Wei Shi, Chenling Meng, Jie Zhang, Kaitlyn Tremble, Xin Liang, Jian H Song, Xu Feng, Vivien Van, Pingna Deng, Burks JK, Ana Aparicio, Khandan Keyomarsi, Junjie Chen, Yue Lu, Himisha Beltran, Di Zhao. CHD1 Promotes SensitivityCHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2. Cancer Research 82(17), 2022.
- Luana Guimaraes de Sousa, Daniel J McGrail, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Hui Dai, Sammy Ferri-Borgogno, Myrna Godoy, Burks JK, Shiaw-Yih Lin, Diana Bell and Renata Ferrarotto. Spontaneous tumor regression following COVID-19 vaccination. J Immunother Cancer 10(3), 2022.
- Salah-Eddine Bentebibel, Daniel Johnson, Rodabe Amariae, Daniel McGrail, Srisuda Lecagoonporn, Cara Haymaker,Dzifa Duose, Khalida Wani, Houssein Safa, Isabella Claudia Glitza, Sapna Pradyuman Patel, Michael K. Wong, Hussein Tawbi, Burks JK, Xiaodong Yang, Patrick Hwu, Cassian Yee, Michael A. Davies, Ravi Murthy, Chantale Bernatchez Suhendan Ekmekcioglu, Adi Diab, Gregory Lizée. CT039 - Intratumoral CD40 agonist sotigalimab with pembrolizumab induces broad innate and adaptive immune activation in local and distant tumors in metastatic melanoma. Cancer Research, 2022.
- Heimberger et al. T-cell interactions vary between tumor microenvironments. Northwestern University ~ Feinberg School of Medicine, 2022.
- Sivareddy Kotla et al. An ERK5-NRF2 axis mediates senescence-associated stemness and atherosclerosis. 29th Annual Conference of the Society for Redox Biology and Medicine, 2022.
- Sammy Ferri-Borgogno, Ying Zhu, Jianting Sheng, Burks JK, Javier Gomez, Kwong Kwok Wong, Stephen T.C. Wong, Samuel C. Mok. Long-term ovarian cancer survivors: spatial transcriptomics depict ligand-receptor crosstalk heterogeneity at the tumor-stroma interface. Cancer Research, 2022.
- Julienne L Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M McAndrews, Arvind Rao, Burks JK, Andrew D Rhim, Raghu Kalluri. Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis. Cancer Research 81(22_Supplement):PO-059-PO-059, 2021.
- Víctor Arrieta, Andrew X Chen, J Robert Kane, Seong Jae Kang, Cynthia Kassab, Crismita Dmello, Junfei Zhao, Kirsten Burdett, Pavan Upadhyayula, Catalina Chang, Joseph Shilati, Dinesh Jaishankar, Li Chen, Andrew Gould, Daniel Zhang, Jinzhou Yuan, Wenting Zhao, Xiaoyang Ling, Burks JK, Brice Laffleur, Christina Amidei, Jeffrey N Bruce, Rimas V Lukas, Jonathan T Yamaguchi, David Cieremans, Gerson Rothschild, Uttiya Basu, Matthew McCord, Daniel Brat, Hui Zhang, Lee AD Cooper, Bin Zhang, Peter Sims, Timothy Cloughesy, Robert Prins, Peter Canoll, Roger Stupp, Amy B Heimberger, Craig Horbinski, Fabio Iwamoto, Raul Rabadan, Adam M Sonabend. BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA. Neuro-Oncology 23(Supplement_6):vi17-vi17, 2021.
- Hinda Najem, Anantha Marisetty, Craig Horbinski, Burks JK, Amy B Heimberger. LMD-20. Immune Suppressive Macrophages and Signal Transducer and Activator of Transcription 3 (STAT3) Expression are common in Melanoma Leptomeningeal Disease. Neuro-Oncology Advances 3, 2021.
- Han T. Cun; Sammy Ferri-Borgogno; Rita Cheng; Jae-hoon Kim; Gwan Hee Han; Jared K. Burks; Karen H. Lu; Samuel C. Mok. The immune landscape of recurrent ovarian carcinoma. Cancer Research 81(13_Supplement):2744-2744, 2021.
- Rafael Heinz Montoya, Rasoul Pourebrahim, Zoe Alaniz, Lauren Ostermann, Burks JK and Michael Andreeff. Osterix Marks a Distinct Population of Circulatory Bone Marrow Mesenchymal Stem Cells That Is Increased upon Oncogenic Stress. Blood 136, 2020.
- Rasoul Pourebrahim, Rafael Heinz Montoya, Zoe Alaniz, Lauren Ostermann, Edward Ayoub, Patrick P. Lin, Burks JK and Michael Andreeff. Mdm2 Haplo-insufficiency in Hematopoietic and Mesenchymal Progenitor Cells Results in Cell Death. Blood 136:10, 2020.
- H. Cun, E.M. Hinchcliff, Y. Zhu, S. Ferri-Borgogno, R. Cheng,Burks JK, S.T.C. Wong, A.A. Jazaeri and S.C. Mok. Identification of a novel biomarker response in a prospective clinical trial of immune checkpoint blockade in high grade ovarian carcinoma. Gynecologic Oncology 159:143, 2020.
- Sanghoon Lee, Li Zhao, Christine Rojas, Nicholas William Bateman, Hui Yao, Olivia D Lara, Amir Anthony Jazaeri, Jinsong Liu, Burks JK, Nicole D Fleming, Karen Hsieh Lu, Shannon N Westin, Robert L Coleman, Gordon B Mills, Jianhua Zhang, Thomas P Conrads, George Larry Maxwell, Phillip Andrew Futreal, Anil K Sood. A high-depth multi-omics analysis of clinically defined subsets of high-grade serous ovarian cancer. Gynecologic Oncology 159:77, 2020.
- Ying Zhu; Sammy Ferri-Borgogno; Jianting Sheng; Tsz-Lun Yeung; Burks JK; Paola Cappello; Amir A. Jazaeri; Jae-Hoon Kim; Gwan Hee Han; Michael J. Birrer; Samuel C. Mok; Stephen T.C. Wong. Deep learning on image-omics data in identifying prognostic immune biomarkers for ovarian cancer, 2020.
- Rafael Heinz Montoya, Rasoul Pourebrahim, Zoe Alaniz, Lauren B Ostermann, Burks JK , Michael Andreeff. High-Dimensional Single-Cell Proteomic Analysis Reveals Therapeutic Vulnerabilities in Relapsed/Refractory AML By Concomitant Analysis of Cell Surface Antigens, Signaling Pathways and Anti-Apoptotic Proteins. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA 20:S206-S207, 2020.
- Pedro Rocha, Luisa Solis, Edwin Parra, Ou Shi, Barbara Mino, Vidya Sinha, Amanda Lynn Rinkenbaugh, Auriole Tamegnon, Mark Duncan, Wei Lu, Mei Jiang, Lakshmi Kakarala, Burks JK, Helen Piwnica-Worms, Michael Teztlaff, Ignacio Wistuba, Alejandro Francisco-Cruz. Immuno-oncology panel optimization for Imaging Mass Cytometry and digital image analysis of tumor tissues. Cancer Research(16_Supplement):2679-2679, 2020.
- Pedro Rocha, Luisa Solis, Edwin Parra, Ou Shi, Barbara Mino, Vidya C. Sinha, Amanda Rinkenbaugh, Auriole Tamegnon, Mak Duncan, Wei Lu, Mei Jiang, Lakshimi Kakarala, Burks JK, Helen Piwnica-Worms, Cara Haymacker, Michael Teztlaff, Ignacio Wistuba, and Alejandro Francisco-Cruz. Immuno-oncology panel optimization for Imaging Mass Cytometry and digital image analysis of tumor tissues. AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA 80(16), 2020. e-Pub 2020.
- H. Cun, E.M. Hinchcliff, Y. Zhu, S. Ferri-Borgogno, R. Cheng, Burks JK, S.T.C. Wong, A.A. Jazaeri and S.C. Mok. Identification of a novel biomarker response in a prospective clinical trial of immune checkpoint blockade in recurrent ovarian carcinoma. Cancer Research, 2020.
- Ying Zhu, Jianting Sheng, Sammy Ferri-Borgogno, Tsz-Lun Yeung, Burks JK, Samuel C Mok, Stephen T Wong. An artificial intelligence pipeline for imaging mass cytometry data analysis and it application in ovarian cancer prognostic biomarker discovery. Cancer Research 80(16_Supplement):854-854, 2020.
- Sivareddy Kotla, Aijun Zhang, Masaki Imanishi, Kyung Ae Ko, Steven H. Lin, Young Jin Gi, Keigi Fujiwara, Burks JK, Nhat-Tu Le, Dale J. Hamilton, and Jun-ichi Abe. Stress-induced premature aging mediated by mitochoindrial hibernation promotes atherosclerosis. IVBM 2020, 2020.
- Burks JK, Savanh Chanthaphavong, Travis Hollman, Cynthia Loomis, Valeria Mezzano. Beyond Spatial Transcriptomics: Tissue Systems Biology. Journal of biomolecular techniques: JBT 31(Suppl):S33, 2020.
- Masaki Imanishi, Kyung Ae Ko, Sivareddy Kotla, Tamlyn N Thomas, Young Jin Gi, Yin Wang, Keigi Fujiwara, Hannah Savage, Loka reddy Velatooru, Keri Schadler, Ying H Shen, Nhat Tu Le, Burks JK, Junichi Abe. Abstract 320: Novel Simultaneous Multiplexed Imaging With Subcellular Resolution in Atherosclerosis Plaque by Mass Cytometry (Imaging Mass Cytometry). Arteriosclerosis, Thrombosis, and Vascular Biology 40(Suppl_1):A320-A320, 2020.
- Julienne L. Carstens, Pedro Correa de Sampaio, Soutik Barua, Huamin Wang, Burks JK, Arvind Rao, Valerie S. LeBleu, and Raghu Kalluri. Abstract PR08: Intratumoral T-cell distribution in murine and patient pancreatic cancer correlates with tissue heterogeneity and survival. CANCER RESEARCH 79(24), 2019.
- Burks JK. Mass Cytometry Why Multiplex. Journal of Biomolecular Techniques: JBT 30(Suppl):S54, 2019.
- Michael Andreeff, Jianfang Zeng, Alice Soragni, Vivian Ruvolo, Bing Z Carter, Jo Ishizawa, Burks JK, David Eisenberg. Targeting Misfolded p53 and p53 Aggregation to Overcome Resistance to Apoptosis in Acute Myeloid Leukemia. Blood 134:3786, 2019.
- Mahesh Swaminathan, Kiyomi Morita, Yan Yuanqing, Feng Wang, Burks JK, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Jianhua Zhang, Xingzhi Song, Courtney D DiNardo, Elias J Jabbour, Tapan M Kadia, Jorge E Cortes, Naval G Daver, Naveen Pemmaraju, Keyur Patel, Guillermo Garcia-Manero, Hagop M Kantarjian, Carlos E Bueso-Ramos, Andy Futreal, Koichi Takahashi. Clinical heterogeneity of AML is associated with mutational heterogeneity. Blood 132:5240, 2019.
- Ying Zhu; Yeung,Tsz-Lun; Jianting Sheng; Hinchcliff,Emily Moss; Burks JK; Jazaeri,Amir A; Mok,Samuel; Stephen Wong. An image informatics pipeline for imaging mass cytometry to characterize the immune landscape in pre- and on-treatment immune therapy and its application in recurrent platinium-resistant epithelial ovarian cancer. 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI):1-4, 2019.
- Coya Tapia et al. Image Mass Cytometry to Detect Immune Cells and Predictive Biomarkers in Formalin-Fixed and Paraffin-Embedded Tissue. USCAP 2019 Annual Meeting, 2019.
- Yasmeen Rizvi, Burks JK, Duncan Mak, Funda Meric-Bernstam, Coya Tapia. Image Mass Cytometry to Detect Immune Cells and Predictive Biomarkers in Formalin-Fixed and Paraffin-Embedded Tissue. Laboratory Investigation 99. e-Pub 2019.
- Lina Han, Peng Qiu, Jeffrey L Jorgensen, Duncan Mak, Burks JK, Teresa McQueen, Zhihong Zeng, Farhad Ravandi, Gail J Roboz, Hagop M Kantarjian, Steven M Kornblau, Michael Andreeff, Monica L Guzman, Marina Y Konopleva. Single-cell mass cytometry characterizes phenotypic and functional heterogeneity in acute myeloid leukemia at diagnosis, in remission and relapse. Blood 132:912, 2018.
- Bin Yuan, Stanley Ly, Khoa Nguyen, Vivien Tran, Kiersten Maldonado, Charles Kinglsey, Burks JK, Xin Zhou, Benoit deCrombrugghe, Michael Andreeff, Venkata Lokesh Battula. Acute myeloid leukemia expands osteoprogenitor rich niche in the bone marrow but resorbs mature bone causing osteopenia/osteoporosis in animal models. Blood 132:86, 2018.
- Omar Saldarriaga, Adam Booth, Burks JK, Netanya Sandler Utay, Monique Ferguson, Laura Beretta, Heather Lynne Stevenson-Lerner. Multispectral Imaging Reveals Unique Macrophage Profiles Associated with Type of Liver Disease and Fibrosis Stage. HEPATOLOGY 68, 2018.
- Kiyomi Morita, Feng Wang, Yuanqing Yan, Burks JK, Curtis Gumbs, Little Latasha, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Jianhua Zhang, Song Xingzhi, Courtney DiNardo, Elias Jabbour, Michael Andreeff, Jorge Cortes, Marina Konopleva, Keyur Patel, Guillermo Garcia-Manero, Hagop Kantarjian, Carlos Bueso-Ramos, P Andrew Futreal, Koichi Takahashi. The Landscape of Genotype-Phenotype Correlation in AML. Clinical Lymphoma, Myeloma and Leukemia 18:S209-S210, 2018.
- Joseph Anthony Dottino, Yunyun Jiang, Sarita Shah, Joseph Celestino, Emma Watson, Qian Zhang, Gary Chisholm, Burks JK, Antonios Mikos, Karen Hsieh Lu, Melinda S Yates. Novel intrauterine polymer system delivers everolimus at biologically active levels in rats. SGO 49th Annual Meeting on Women's Cancer, 2018.
- Fiegl M, Samudio IJ, Dwyer KC, Burks JK, Fritsche H, Mnjoyan ZH, Andreeff M. CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia. Blood 112(11), 2008.
- Ramsay AG, Xing D-X, Decker WK, Burks JK, Wierda WG, Gribben JG, Shpall EJ. Compared to Adult Peripheral Blood T Cells, Cord Blood T Cells Show Enhanced Immunological Recognition of Chronic Lymphocytic Leukemia Tumor Cells 112(2333), 2008.
- Zhang W, Konopleva M, Burks JK, Dywer K, Schober W, Yang JY, McQueen T, Hung MC, Andreeff M. Apoptosis induction in acute myeloid leukemia by inhibition of MEK and MDM2 is strongly associated with the BH3-only proteins Puma and Bim, 2008.
- Braunagel SC, Saksena S, Burks JK, Johnson AE, Summers MD. Importin alpha-16: a translocon-associated protein potentially involved in sorting integral membrane proteins to the nuclear envelope, 2006.
- Zhang C, Zhang M-X, Shen YH, Burks JK, Zhang Y, LeMaire SA, Coselli JS, Wang XL. TNF{alpha} Suppresses Prolyl-4-Hydroxylase a (I) (P4Ha(I)) Expression and Collagen Processing in Aortic SMCs via JNK Pathway, 2006.
- Zhang M-X, Shen YH, Zhang C, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL. Endogenous eNOS-Specific 27nt MicroRNA is derived through Pre-mRNA Splicing, 2006.
- Zhang M-X, Zhang C, Shen YH, Zhang L, Burks JK, Wang J, Coselli JS, Wang XL. Endogenous 27nt microRNA inhibits eNOS Expression through DNA Methylation, 2006.
Book Chapters
- Chandra V, McAllister F, Burks JK . Cytometry of Mass for Murine Immunoprofiling. In: Methods Mol Biol, 129-137, 2022.
- Burks JK. Imaging tools for cellular uptake and intracellular trafficking. In: Mass transport of Nanocarriers. Pan Stanford Publishing Pte. Ltd, 221-240, 2012.
Grant & Contract Support
| Date: | 2023 - 2026 |
| Title: | Identifying, Understanding, and Eradicating Measurable Residual Disease (MRD) in Patients with Acute Myeloid Leukemia (AML) |
| Funding Source: | Break Through Cancer |
| Role: | Researcher |
| ID: | FP00018527 |
| Date: | 2022 - 2027 |
| Title: | Acquired Resistance to Therapy and Iron (ARTI) Center |
| Funding Source: | NIH/NCI |
| Role: | Significant Contributor |
| ID: | U54CA274220 |
| Date: | 2020 - 2025 |
| Title: | Single Cell Spatial Analysis in Tissue |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| ID: | 1R50CA243707-01A1 |
| Date: | 2019 - 2026 |
| Title: | Cancer Center Support Grant, PP-SR-12; Flow Cytometry and Cellular Imaging Facility |
| Funding Source: | NIH/NCI |
| Role: | Co-Director of Shared Resource Core Facility |
| ID: | 5P30 CA016672 |
| Date: | 2014 - 2015 |
| Title: | New Technology Implementation in Shared Resources: FCCIF Web Analysis Tool |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| ID: | 5 P30 CA016672 |
| Date: | 2013 - 2014 |
| Title: | New Technology Implementation in Shared Resources, CyTOF Single Cell Proteomics |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 5P30 CA016672 |
| Date: | 2012 - 2015 |
| Title: | CyTOF Mass Cytometer and Element Tagging System |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Research Scientist |
| ID: | RP121010 |
Patient Reviews
CV information above last modified January 29, 2025