Jared K. Burks, Ph.D.
Department of Leukemia, Division of Cancer Medicine
About Dr. Burks
I started my career in science as a research assistant in Dr. Max D. Summers’ laboratory. We studied protein trafficking in baculovirus-infected cells where I became familiar with, and interested in, spinning-disk confocal imaging. This led to my enrollment in several imaging courses, and ultimately my entry into graduate school and back to Dr. Summers’ laboratory. During my PhD training, Dr. Summers placed me in charge of the confocal microscope, where I trained every user and developed imaging assays as a basic core service. Ultimately, I ended up identifying importin-alpha-16, which is a shuttling protein involved in moving integral membrane proteins through the lateral channel of the nuclear pore complex. This was based in large part on my previous imaging experiments with BV/ODV E26, which was identified as a viral homolog to the eukaryotic importin-alpha-16. After completing my PhD, I joined Dr. Xing Li Wang’s group at Baylor, where I continued to study viral protein trafficking in infected cells. In doing so, I also learned how to interact with people from other cultures and how to collaborate on a larger scale. I also mastered extensive problem-solving skills that allowed me to determine where technical errors were made in our research efforts, which facilitated in my resolving them quickly and efficiently. I found that I enjoyed this type of technical problem solving, albeit I was not able to perform as much imaging work as I had anticipated. Therefore, after my postdoctoral work, I sought employment in a shared resource facility that specialized in imaging. I secured a position with the Flow Cytometry and Cellular Imaging Core Facility at MD Anderson Cancer Center where I have flourished. In fact, I am now an Associate Professor and Co-Director of the facility. I have brought eight color imaging to the Institution through the use of FFPE sampling and multispectral microscopy. I have also introduced and established mass cytometry, CyTOF, (imaging and suspension) to our Institution. The latest iteration of CyTOF technology is imaging-based. It uses laser ablation to free material from the slide for analysis through the CyTOF. My other focus is on live cell spinning disk confocal imaging. This has been a need for some time among MD Anderson Cancer Center researchers. Through my actions with these technologies I sought fund and was awarded an NIH R50 research specialist grant. I continue to focus on these technologies as we examine the spatial distribution of cells in tissues of the tumor microenvironment. I wish to understand the functional interactions that occur in unique spatial niche. My strengths have always been, and continue to be, that I am technically trained to identify, adapt, and utilize emerging technologies to answer critical questions in cutting-edge research here at MD Anderson Cancer Center and elsewhere in the scientific community. We tackle these problems every day at the Flow Cytometry and Cellular Imaging Core Facility at MD Anderson, and we jointly develop solutions with our research collaborators to produce outstanding scientific discoveries.
Present Title & Affiliation
Primary Appointment
Professor, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Flow Cytometry & Cell Imaging Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Spatial imaging
Mass Cytometry
Imaging Mass Cytometry
Live cell imaging
Confocal Imaging
Education & Training
Degree-Granting Education
| 2005 | Texas A&M University, College Station, TX, USA, PHD, Biology |
| 1995 | Florida Institute of Technology, Melbourne, FL, USA, BS, Molecular Biology |
| 1995 | Florida Institute of Technology, Melbourne, FL, USA, BS, Pre-Professional Biology |
Postgraduate Training
| 2006-2007 | Postdoctoral Associate, Baylor College of Medicine, Houston, TX |
Experience & Service
Other Appointments/Responsibilities
Associate Professor, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2021
Assistant Professor, The University of Texas MD Anderson Cancer Center ~ Department of Leukemia, Houston, TX, 2010 - 2018
Research Scientist, Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2010
Postdoctoral Associate, Baylor College of Medicine - Division of Cardiothoracic Surgery - Michael DeBakey Department of Surgery, Houston, TX, 2006 - 2007
Research Assistant, The Max D. Summers Laboratory, Department of Entomology, College Station, TX, 1995 - 1998
Necropsy Assistant, Arkansas Livestock and Poultry Pathology Laboratory, Little Rock, AR, 1993 - 1993
Laboratory Assistant, Medical Genetics Laboratory, Department of Biology, Melbourne, FL, 1990 - 1994
Institutional Committee Activities
Member, Digital Pathology Workforce, 2020 - Present
Member, Alternate Technologies for COVID Task Force, 2020 - Present
Committee Member, Basic Science/Laboratory Research Recovery Plan Committee, 2020 - 2020
Member, TMC3 Science Think Tank, 2020 - Present
Member, DIY PPE Task Force, 2020 - 2020
Committee Member, Research Storage Planning & Governance Committee, 2014 - Present
Member, SharePoint Advisory Team, 2013 - 2015
Member, Research IT Steering Committee, 2012 - 2013
Consultantships
Industry Advisory Board Member, University of Houston, Houston, Texas, 2020 - 2023
Honors & Awards
| 2004 | American Society of Virology, 2004 Annual Meeting, McGill University, Montreal, Canada |
| 2003 | Entomology Graduate Student Forum Presentation Award, Texas A&M University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Víctor Arrieta, Andrew Chen, J Kane, Seong Jae Kang, Cynthia Kassab, Crismita Dmello, Raul Zhao, Kirsten Burdett, Pavan Upadhyayula, Catalina Lee-Chang, Joseph Shilati, Dinesh Jaishankar, Li Chen, Andrew Gould, Daniel Zhang, Jinzhou Yuan, Wenting Zhao, Xiaoyang Ling, Burks JK, Brice Laffleur, Christina Amidei, Jeffrey Bruce, Rimas Lukas, Jonathan Yamaguchi, David Cieremans, Gerson Rothschild, Uttiya Basu, Matthew McCord, Daniel Brat, Hui Zhang, Lee Cooper, Bin Zhang, Peter Sims, Timothy Cloughesy, Robert Prins, Peter Canoll, Roger Stupp, Amy Heimberger, Craig Horbinski, Fabio Iwamoto, Raul Rabadan, and Adam Sonabend. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Cancer NATCANCER-A04303-T, 2021.
- Bommi PV, Bowen CM, Reyes-Uribe L, Wu W, Katayama H, Rocha P, Parra ER, Francisco-Cruz A, Ozcan Z, Tosti E, Willis JA, Wu H, Taggart MW, Burks JK, Lynch PM, Edelmann W, Scheet PA, Wistuba II, Sinha KM, Hanash SM, Vilar E. The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells. Cancer Res 81(10):2760-2773, 2021. e-Pub 2021. PMID: 34003775.
- Carstens JL, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews KM, Rao A, Burks JK, Rhim AD, Kalluri R. Stabilized Epithelial Phenotype of Cancer Cells in Primary Tumors Leads to Increased Colonization of Liver Metastasis in Pancreatic Cancer. Cell Rep 35(2):108990, 2021. PMID: 33852841.
- Yared Hailemichael, Daniel H. Johnson, Noha Abdel-Wahab, Wai Chin Foo, May Daher, Cara Haymaker, Khalida M. Wani, Chantal M. Saberian, Dai Ogata, Salah Eddine Bentebibel, Sang Taek Kim, Roza Nurieva, Alexander Lazar, Hamzah Abu-Sbeih, Yinghong Wang, Van Anh Trinh, Chrystia M. Zobniw, Christine A. Spillson, Burks JK, Luisa Solis, Alejandro Francisco Cruz, Mario Luiz Marques-Piubelli, Wei Lu, Brenda Denisse Melendez, Michael A. Davies, Jennifer Wargo, Jonathan L. Curry, Gregory A. Lizee, Cassian Yee, Patrick Hwu, Suhendan Ekmekcioglu, Adi Diab. Interleukin-6 blockade abrogates CTLA-4 blockade immune toxicity and promotes antitumor immunity. Cell, 2021.
- Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V. Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Haematologica 106(2):495-512, 2021. e-Pub 2021. PMID: 32029507.
- Najem H, Marisetty A, Horbinski C, Long J, Huse JT, Glitza Oliva IC, Ferguson SD, Kumthekar PU, Wainwright DA, Chen P, Lesniak MS, Burks JK, Heimberger AB. CD11c+CD163+ Cells and Signal Transducer and Activator of Transcription 3 (STAT3) Expression Are Common in Melanoma Leptomeningeal Disease. Front Immunol 12:745893, 2021. e-Pub 2021. PMID: 34691054.
- Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks JK, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya P, McAllister F. Interleukin 17 induced- neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217(12), 2020. PMID: 32860704.
- Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling. Gastroenterology 159(6):2146-2162.e33, 2020. e-Pub 2020. PMID: 32805281.
- Ott M, Kassab C, Marisetty A, Hashimoto Y, Wei J, Zamler D, Leu JS, Tomaszowski KH, Sabbagh A, Fang D, Gupta P, Priebe W, Zielinski RJ, Burks JK, Long JP, Kong LY, Fuller GN, DeGroot J, Sulman EP, Heimberger AB. Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy. Clin Cancer Res 26(18):4983-4994, 2020. e-Pub 2020. PMID: 32605912.
- Batth IS, Meng Q, Wang Q, Torres KE, Burks JK, Wang J, Gorlick R, Li S. Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis. BMC Cancer 20(1):715, 2020. e-Pub 2020. PMID: 32736533.
- Saldarriaga OA, Freiberg B, Krishnan S, Rao A, Burks JK, Booth AL, Dye B, Utay N, Ferguson M, Akil A, Yi M, Beretta L, Stevenson HL. Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease. Hepatol Commun 4(5):708-723, 2020. e-Pub 2020. PMID: 32363321.
- Lee S, Zhao L, Rojas C, Bateman NW, Yao H, Lara OD, Celestino J, Morgan MB, Nguyen TV, Conrads KA, Rangel KM, Dood RL, Hajek RA, Fawcett GL, Chu RA, Wilson K, Loffredo JL, Viollet C, Jazaeri AA, Dalgard CL, Mao X, Song X, Zhou M, Hood BL, Banskota N, Wilkerson MD, Te J, Soltis AR, Roman K, Dunn A, Cordover D, Eterovic AK, Liu J, Burks JK, Baggerly KA, Fleming ND, Lu KH, Westin SN, Coleman RL, Mills GB, Casablanca Y, Zhang J, Conrads TP, Maxwell GL, Futreal PA, Sood AK. Molecular analysis of clinically defined subsets of high-grade serous ovarian cancer. Cell Rep 31(2):107502, 2020. PMID: 32294438.
- Han L, Zhang Q, Dail M, Shi C, Cavazos A, Ruvolo VR, Zhao Y, Kim E, Rahmani M, Mak DH, Jin SS, Chen J, Phillips DC, Koller PB, Jacamo R, Burks JK, DiNardo C, Daver N, Jabbour E, Wang J, Kantarjian HM, Andreeff M, Grant S, Leverson JD, Sampath D, Konopleva M. Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models. Haematologica 105(3):697-707, 2020. e-Pub 2019. PMID: 31123034.
- Yokoi A, Villar-Prados A, Oliphint PA, Zhang J, Song X, De Hoff P, Morey R, Liu J, Roszik J, Clise-Dwyer K, Burks JK, O'Halloran TJ, Laurent LC, Sood AK. Mechanisms of nuclear content loading to exosomes. Sci Adv 5(11), 2019. e-Pub 2019. PMID: 31799396.
- Lara OD, Krishnan S, Wang Z, Corvigno S, Zhong Y, Lyons Y, Dood R, Hu W, Qi L, Liu J, Coleman RL, Westin SN, Fleming ND, Cristini V, Rao A, Burks JK, Sood AK. Tumor core biopsies adequately represent immune microenvironment of high-grade serous carcinoma. Sci Rep 9(1):17589, 2019. e-Pub 2019. PMID: 31772388.
- Chattopadhyay C, Oba J, Roszik J, Marszalek JR, Chen K, Qi Y, Eterovic K, Robertson AG, Burks JK, McCannel TA, Grimm EA, Woodman SE. Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma. Invest Ophthalmol Vis Sci 60(13):4187-4195, 2019. PMID: 31596927.
- Kannan S, Aitken MJL, Herbrich SM, Golfman LS, Hall MG, Mak DH, Burks JK, Song G, Konopleva M, Mullighan CG, Chandra J, Zweidler-McKay PA. Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther 18(9):1615-1627, 2019. e-Pub 2019. PMID: 31227645.
- Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F. Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell 178(4):795-806.e12, 2019. PMID: 31398337.
- Carter BZ, Mak PY, Wang X, Tao W, Ruvolo V, Mak D, Mu H, Burks JK, Andreeff M. An ARC-regulated IL1β/Cox-2/PGE2/β-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML. Cancer Res 79(6):1165-1177, 2019. e-Pub 2019. PMID: 30674535.
- Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape. Oncoimmunology 8(4):e1568809, 2019. e-Pub 2019. PMID: 30906661.
- Reddy JP, Atkinson RL, Larson R, Burks JK, Smith D, Debeb BG, Ruffell B, Creighton CJ, Bambhroliya A, Reuben JM, Van Laere SJ, Krishnamurthy S, Symmans WF, Brewster AM, Woodward WA. Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Res Treat 171(2):283-293, 2018. e-Pub 2018. PMID: 29858753.
- Ruvolo PP, Ruvolo VR, Burks JK, Qiu Y, Wang RY, Shpall EJ, Mirandola L, Hail N, Zeng Z, McQueen T, Daver N, Post SM, Chiriva-Internati M, Kornblau SM, Andreeff M. Role of MSC-derived galectin 3 in the AML microenvironment. Biochim Biophys Acta Mol Cell Res 1865(7):959-969, 2018. e-Pub 2018. PMID: 29655803.
- Jiang X, Mak PY, Mu H, Tao W, Mak DH, Kornblau S, Zhang Q, Ruvolo P, Burks JK, Zhang W, McQueen T, Pan R, Zhou H, Konopleva M, Cortes J, Liu Q, Andreeff M, Carter BZ. Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition inFLT3-Mutant Acute Myeloid Leukemia. Clin Cancer Res 24(10):2417-2429, 2018. e-Pub 2018. PMID: 29463558.
- McCarthy RL, Mak DH, Burks JK, Barton MC. Rapid monoisotopic cisplatin based barcoding for multiplexed mass cytometry. Sci Rep 7(1):3779, 2017. e-Pub 2017. PMID: 28630464.
- Liu S, Anfossi S, Qiu B, Zheng Y, Cai M, Fu J, Yang H, Liu Q, Chen Z, Fu J, Liu M, Burks JK, Lin SH, Reuben J, Liu H. Prognostic Factors for Locoregional Recurrence in Patients with Thoracic Esophageal Squamous Cell Carcinoma Treated with Radical Two-Field Lymph Node Dissection: Results from Long-Term Follow-Up. Ann Surg Oncol 24(4):966-973, 2017. e-Pub 2016. PMID: 27804027.
- Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, Joo J, Kim SC, Yun JS, Na KJ, Choi YL, Park JL, Kim SY, Lee YS, Han L, Liang H, Mak D, Burks JK, Zo JI, Sugarbaker DJ, Shim YM, Lee JS. Integrated Genomic Analysis of Recurrence-Associated Small Non-coding RNAs in Oesophageal Cancer. Gut 66(2):215-225, 2017. e-Pub 2016. PMID: 27507904.
- Mansfield JR, Guest PC,Burks JK. Phenotyping Multiple Subsets of Immune Cells In Situ in Formalin-Fixed, Paraffin-Embedded Tissue Sections. Adv Exp Med Biol 974:327-338, 2017. PMID: 28353253.
- Ruvolo PP, Ruvolo VR, Benton CB, AlRawi A, Burks JK, Schober W, Rolke J, Tidmarsh G, Hail N, Davis RE, Andreeff M. Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells. Biochim Biophys Acta 1863(4):562-71, 2016. e-Pub 2015. PMID: 26704388.
- Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M. Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network. Oncotarget 7(15):20054-67, 2016. PMID: 26956049.
- Nduom EK, Wei J, Yaghi NK, Huang N, Kong LY, Gabrusiewicz K, Ling X, Zhou S, Ivan C, Chen JQ, Burks JK, Fuller GN, Calin GA, Conrad CA, Creasy C, Ritthipichai K, Radvanyi L, Heimberger AB. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol 18(2):195-205, 2016. e-Pub 2015. PMID: 26323609.
- Han L, Qiu P, Zeng Z, Jorgensen JL, Mak DH, Burks JK, Schober W, McQueen TJ, Cortes J, Tanner SD, Roboz GJ, Kantarjian HM, Kornblau SM, Guzman ML, Andreeff M, Konopleva M. Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry A 87(4):346-56, 2015. e-Pub 2015. PMID: 25598437.
- Zhang Y, Nowicka A, Solley TN, Wei C, Parikh A, Court L, Burks JK, Andreeff M, Woodward WA, Dadbin A, Kolonin MG, Lu KH, Klopp AH. Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers. PLoS One 10(8):e0136361, 2015. e-Pub 2015. PMID: 26317219.
- Ruvolo PP, Ruvolo VR, Benton C, Burks JK, Schober W, Rolke J, Tidmarsh G, Hail N, Davis E, Andreeff M. Galectin inhibitor GCS-100 synergizes with BH3 mimetics to eliminate AML cells and sensitizes AML cells to KPT-185 be a mechanism involving suppression of XPO1. Biochim Biophys Acta, 2015.
- Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks JK, Jacamo R, Kojima K, Ruvolo P, Fueyo-Margareto J, Konopleva M, Andreeff M. MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. PLoS One 10(10):e0139254, 2015. e-Pub 2015. PMID: 26440941.
- Ruvolo PP, Ruvolo VR, Jacamo R, Burks JK, Zeng Z, Duvvuri SR, Zhou L, Qiu Y, Coombes KR, Zhang N, Yoo SY, Pan R, Hail N, Konopleva M, Calin G, Kornblau SM, Andreeff M. The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Biochim Biophys Acta 1843(9):1969-77, 2014. e-Pub 2014. PMID: 24858343.
- Mak PY, Mak DH, Mu H, Shi Y, Ruvolo P, Ruvolo V, Jacamo R, Burks JK, Wei W, Huang X, Kornblau SM, Andreeff M, Carter BZ. Apoptosis Repressor with Caspase Recruitment Domain Is Regulated by MAPK/PI3K and Confers Drug Resistance and Survival Advantage to AML. Apoptosis 19(4):698-707, 2014. e-Pub 2013. PMID: 24337870.
- Kojima K, Kornblau SM, Ruvolo V, Dilip A, Duvvuri S, Davis RE, Zhang M, Wang Z, Coombes KR, Zhang N, Qiu YH, Burks JK, Kantarjian H, Shacham S, Kauffman M, Andreeff M. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood 121(20):4166-74, 2013. e-Pub 2013. PMID: 23564911.
- Shah N, Martin-Antonio B, Yang H, Ku S, Lee DA, Cooper LJ, Decker WK, Li S, Robinson SN, Sekine T, Parmar S, Gribben J, Wang M, Rezvani K, Yvon E, Najjar A, Burks JK, Kaur I, Champlin RE, Bollard CM, Shpall EJ. Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity. PLoS One 8(10):1-9, 2013. e-Pub 2013. PMID: 24204673.
- Mazurek N, Byrd JC, Sun Y, Hafley M, Ramirez K, Burks JK, Bresalier RS. Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ 19(3):523-33, 2012. e-Pub 2011. PMID: 21941373.
- Kidd S, Spaeth E, Watson K, Burks JK, Lu H, Klopp A, Andreeff M, Marini FC. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7(2):e30563, 2012. e-Pub 2012. PMID: 22363446.
- Ruvolo PP, Zhou L, Watt JC, Ruvolo VR, Burks JK, Jiffar T, Kornblau S, Konopleva M, Andreeff M. Targeting PKC Mediated Signal Transduction Pathways Using Enzastaurin to Promote Apoptosis in Acute Myeloid Leukemia-derived Cell Lines and Blast Cells. J Cell Biochem 112(6):1696-707, 2011. e-Pub 2011. PMID: 21360576.
- Kojima K, Burks JK, Arts J, Andreeff M. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther 9(9):2545-57, 2010. e-Pub 2010. PMID: 20736344.
- Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM. Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother 33(7):684-96, 2010. PMID: 20664358.
- Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70(6):2424-34, 2010. e-Pub 2010. PMID: 20215498.
- Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks JK, Clise-Dwyer K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-ß Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron 3(1):83-95, 2010. e-Pub 2010. PMID: 21209776.
- Serda RE, Gu J, Burks JK, Ferrari K, Ferrari C, Ferrari M. Quantitative mechanics of endothelial phagocytosis of silicon microparticles. Cytometry A 75(9):752-60, 2009. PMID: 19610127.
- Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 113(7):1504-12, 2009. e-Pub 2008. PMID: 18957686.
- Zhang C, Zhang MX, Shen YH, Burks JK, Li XN, LeMaire SA, Yoshimura K, Aoki H, Matsuzaki M, An FS, Engler DA, Matsunami RK, Coselli JS, Zhang Y, Wang XL. Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. Biochim Biophys Acta 1783(8):1517-28, 2008. e-Pub 2008. PMID: 18439917.
- Zhang C, Zhang MX, Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. Arterioscler Thromb Vasc Biol 27(8):1760-7, 2007. e-Pub 2007. PMID: 17478756.
- Burks JK, Summers MD, Braunagel SC. BV/ODV-E26: a palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus. Virology 361(1):194-203, 2007. e-Pub 2006. PMID: 17169392.
- Saksena S, Summers MD, Burks JK, Johnson AE, Braunagel SC. Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol 13(6):500-8, 2006. e-Pub 2006. PMID: 16715095.
- Braunagel SC, Burks JK, Rosas-Acosta G, Harrison RL, Ma H, Summers MD. Mutations within the Autographa californica nucleopolyhedrovirus FP25K gene decrease the accumulation of ODV-E66 and alter its intranuclear transport. J Virol 73(10):8559-70, 1999. PMID: 10482609.
- Bing Carter, Po Mak, Ye Chen, Duncan Mak, Hong Mu, Rodrigo O Jacamo, Vivian Ruvolo, Stefan Arold, John Ladbury, Burks JK,Steven Kornblau, Michael Andreeff. The novel role of anti-apoptotic ARC protein in regulating leukemia-stromal interactions.
- Corvigno S, Burks JK, Hu W, Zhong Y, Jennings NB, Fleming ND, Westin SN, Fellman B, Liu J, Sood AK. Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status. J Cancer Res Clin Oncol. e-Pub 2021. PMID: 34476576.
- Ying Zhu; Sammy Ferri-Borgogno; Jianting Sheng; Tsz-Lun Yeung; Burks JK; Paola Cappello; Amir A. Jazaeri; Jae-Hoon Kim; Gwan Hee Han; Michael J. Birrer; Samuel C. Mok; Stephen T.C. Wong. Deep learning on image-omics data in identifying prognostic immune biomarkers for ovarian cancer. Cancer Cell.
- Víctor Arrieta, Andrew Chen, J Kane, Seong Jae Kang, Cynthia Kassab, Crismita Dmello, Raul Zhao, Kirsten Burdett, Pavan Upadhyayula, Catalina Lee-Chang, Joseph Shilati, Dinesh Jaishankar, Li Chen, Andrew Gould, Daniel Zhang, Jinzhou Yuan, Wenting Zhao, Xiaoyang Ling, Burks JK, Brice Laffleur, Christina Amidei, Jeffrey Bruce, Rimas Lukas, Jonathan Yamaguchi, David Cieremans, Gerson Rothschild, Uttiya Basu, Matthew McCord, Daniel Brat, Hui Zhang, Lee Cooper, Bin Zhang, Peter Sims, Timothy Cloughesy, Robert Prins, Peter Canoll, Roger Stupp, Amy Heimberger, Craig Horbinski, Fabio Iwamoto, Raul Rabadan, and Adam Sonabend. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nature Medicine NMED-A104467.
Invited Articles
- Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gumin J, Nwajei F, Rezavanian A, Zhou S, Rao G, Sawaya R, Fuller GN, Huse JT, Antel JP, Li S, Cooper L, Sulman EP, Chen C, Geula C, Kalluri R, Zal T, Heimberger AB. Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. Oncoimmunology 7(4):e1412909, 2018. e-Pub 2018. PMID: 29632728.
Other Articles
- Andreeff M, Zeng Z, Tabe Y, Samudio I, Fiegl M, Watt J, Dietrich, M., McQueen T, Frolova O, Battula L, Mnjoyan Z, Shi Y-X, Konoplev S, Burks JK, Konopleva M Microenvironment and leukemia: Yin and yang. Ann Hematol Suppl:1: S94-S98, 2008.
Abstracts
- Pedro Rocha, Luisa Solis, Edwin Parra, Ou Shi, Barbara Mino, Vidya C. Sinha, Amanda Rinkenbaugh, Auriole Tamegnon, Mak Duncan, Wei Lu, Mei Jiang, Lakshimi Kakarala, Burks JK, Helen Piwnica-Worms, Cara Haymacker, Michael Teztlaff, Ignacio Wistuba, and Alejandro Francisco-Cruz. Immuno-oncology panel optimization for Imaging Mass Cytometry and digital image analysis of tumor tissues. AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA 80(16), 2020. e-Pub 2020.
- Masaki Imanishi, Kyung Ae Ko, Sivareddy Kotla, Tamlyn N Thomas, Young Jin Gi, Yin Wang, Keigi Fujiwara, Hannah Savage, Loka reddy Velatooru, Keri Schadler, Ying H Shen, Nhat Tu Le, Burks JK, Junichi Abe. Abstract 320: Novel Simultaneous Multiplexed Imaging With Subcellular Resolution in Atherosclerosis Plaque by Mass Cytometry (Imaging Mass Cytometry). AHA Vascular Discovery: From Genes to Medicine 2020 Scientific Sessions, 2020.
- Coya Tapia et al. Image Mass Cytometry to Detect Immune Cells and Predictive Biomarkers in Formalin-Fixed and Paraffin-Embedded Tissue. USCAP 2019 Annual Meeting, 2019.
- Fiegl M, Samudio IJ, Dwyer KC, Burks JK, Fritsche H, Mnjoyan ZH, Andreeff M. CXCR4 Expression and Biological Activity Is Dependent on Oxygen Partial Pressure in Acute Myeloid Leukemia. Blood 112(11), 2008.
- Ramsay AG, Xing D-X, Decker WK, Burks JK, Wierda WG, Gribben JG, Shpall EJ. Compared to Adult Peripheral Blood T Cells, Cord Blood T Cells Show Enhanced Immunological Recognition of Chronic Lymphocytic Leukemia Tumor Cells 112(2333), 2008.
- Zhang W, Konopleva M, Burks JK, Dywer K, Schober W, Yang JY, McQueen T, Hung MC, Andreeff M. Apoptosis induction in acute myeloid leukemia by inhibition of MEK and MDM2 is strongly associated with the BH3-only proteins Puma and Bim, 2008.
- Braunagel SC, Saksena S, Burks JK, Johnson AE, Summers MD. Importin alpha-16: a translocon-associated protein potentially involved in sorting integral membrane proteins to the nuclear envelope, 2006.
- Zhang C, Zhang M-X, Shen YH, Burks JK, Zhang Y, LeMaire SA, Coselli JS, Wang XL. TNF{alpha} Suppresses Prolyl-4-Hydroxylase a (I) (P4Ha(I)) Expression and Collagen Processing in Aortic SMCs via JNK Pathway, 2006.
- Zhang M-X, Shen YH, Zhang C, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL. Endogenous eNOS-Specific 27nt MicroRNA is derived through Pre-mRNA Splicing, 2006.
- Zhang M-X, Zhang C, Shen YH, Zhang L, Burks JK, Wang J, Coselli JS, Wang XL. Endogenous 27nt microRNA inhibits eNOS Expression through DNA Methylation, 2006.
- H. Cun, E.M. Hinchcliff, Y. Zhu, S. Ferri-Borgogno, R. Cheng,Burks JK, S.T.C. Wong, A.A. Jazaeri and S.C. Mok. Identification of a novel biomarker response in a prospective clinical trial of immune checkpoint blockade in high grade ovarian carcinoma. SGO 2020 Annual Meeting on Women's Cancer.
- Ivo Veletic et al. Spatial Distribution of Bone Marrow T-Cells and Antigen Presenting Cells Correlates with Inflammation and Disease Burden in Patients with Primary Myelofibrosis. ASH 2019.
- Sanghoon Leea, Li Zhaob, Christine Rojasc,d, Nicholas W. Batemanc,d, Hui Yaoe, Olivia D. Laraf, Jinsong Liug, Burks JK, Nicole D. Flemingf, Karen H. Luf, Shannon N. Westinf, Robert L. Colemanf, Gordon B. Millsa, Jianhua Zhangb, Thomas P. Conradsc, George L. Maxwellc, P. Andrew Futrealb, Anil K. Soodf. A high-depth multi-omics analysis of clinically defined subsets of high-grade serous ovarian cancer. Society of Gynecologic Oncologists (SGO) Conference.
- Han Cun, MD; Emily M. Hincliff, MD; Ying Zhu, PhD; Sammy Ferri-Borgogno, PhD; Rita Cheng, Burks JK; Stephen T.C. Wong, PhD; Amir A. Jazaeri, MD; Samuel C. Mok, PhD. Alterations in immune landscape in ovarian tumors after immune checkpoint inhibitor treatment and their association with progression free survival. Society of Gynecologic Oncologists (SGO) Conference.
- Michael Andreeff, Rodrigo Jacamo, Nguyet Minh Hoang, Zihong Zeng, Sujan Piya, Burks JK, Ahmed Al-Rawi, Gautam Borthakur, Lokesh Battula, Weiguo Zhang, Lina Han, Poo Yee Mak, Hong Mu, Khoa Nguyen, Vivian Ruvolo, Xiangmeng Wang, Natalia Baran, Duncan Mak, Peter Ruvolo, Carlos Bueso-Ramos, Chris Benton, Sergej Konoplev, Steve Kornblau, Bing Carter, Tomasz Zal, Marina Konopleva. BRD4, ARC and CXCR4 as Targets in the AML Microenvironment. European School of Haematology Conference.
Book Chapters
- Burks JK. Imaging tools for cellular uptake and intracellular trafficking. In: Mass transport of Nanocarriers. Pan Stanford Publishing Pte. Ltd, 221-240, 2012.
Grant & Contract Support
| Title: | CyTOF Mass Cytometer and Element Tagging System |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Research Scientist |
| Title: | Cancer Center Support Grant, PP-SR-12; Flow Cytometry and Cellular Imaging Facility |
| Funding Source: | NIH/NCI |
| Role: | Co-Director of Shared Resource Core Facility |
| Title: | New Technology Implementation in Shared Resources, CyTOF Single Cell Proteomics |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | New Technology Implementation in Shared Resources: FCCIF Web Analysis Tool |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Single Cell Spatial Analysis in Tissue |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |