Jason M. Schenkel, M.D., Ph.D.
Department of Laboratory Medicine, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Assistant Professor, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2016 | University of Minnesota, Minneapolis, MN, USA, MD, Medicine |
| 2014 | University of Minnesota, Minneapolis, MN, USA, PHD, Immunology |
| 2008 | Northwestern University, Evanston, IL, USA, BS, Human Communication Sciences |
Postgraduate Training
| 2019-2020 | Clinical Fellowship, Transfusion Medicine, Harvard Medical School, Boston, MA |
| 2018-2022 | Research Fellowship, Massachusetts Institute of Technology, Cambridge, MA |
| 2016-2019 | Clinical Residency, Clinical Pathology, Brigham and Women's Hospital, Boston, MA |
Board Certifications
| 2021 | American Board of Pathology |
Selected Publications
Peer-Reviewed Articles
- Jaeger AM, Stopfer LE, Ahn R, Sanders EA, Sandel DA, Freed-Pastor WA, Rideout WM, Naranjo S, Fessenden T, Nguyen KB, Winter PS, Kohn RE, Westcott PMK, Schenkel JM, Shanahan SL, Shalek AK, Spranger S, White FM, Jacks T. Deciphering the immunopeptidome in vivo reveals new tumour antigens. Nature 607(7917):149-155, 2022. e-Pub 2022. PMID: 35705813.
- Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, Jacks T. Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer. Nature Cancer 2(10):1071-1085, 2021. e-Pub 2021. PMID: 34738089.
- Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether TD, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Cancer Cell 39(10):1342-1360.e14, 2021. e-Pub 2021. PMID: 34358448.
- Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity 54(10):2338-2353.e6, 2021. e-Pub 2021. PMID: 34534439.
- Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, Sharpe AH, Singer M. Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment. Journal Experimental Medicine 218(4), 2021. PMID: 33651880.
- Li A, Herbst RH, Canner D, Schenkel JM, Smith OC, Kim JY, Hillman M, Bhutkar A, Cuoco MS, Rappazzo CG, Rogers P, Dang C, Jerby-Arnon L, Rozenblatt-Rosen O, Cong L, Birnbaum M, Regev A, Jacks T. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Reports 29(10):2998-3008.e8, 2019. PMID: 31801068.
- Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545(7652):60-65, 2017. e-Pub 2017. PMID: 28397821.
- Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 354(6316):1160-1165, 2016. e-Pub 2016. PMID: 27789795.
- Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D. IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells. J Immunol 196(9):3920-6, 2016. e-Pub 2016. PMID: 27001957.
- Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D. Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance. Cell 161(4):737-49, 2015. PMID: 25957682.
- Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity 41(6):886-97, 2014. e-Pub 2014. PMID: 25526304.
- Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science 346(6205):98-101, 2014. e-Pub 2014. PMID: 25170049.
- Schenkel JM, Fraser KA, Masopust D. Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. Journal of Immunology 192(7):2961-4, 2014. e-Pub 2014. PMID: 24600038.
- Schenkel JM, Fraser KA, Vezys V, Masopust D. Sensing and alarm function of resident memory CD8? T cells. Nature Immunology 14(5):509-13, 2013. e-Pub 2013. PMID: 23542740.
- Masopust D, Schenkel JM. The integration of T cell migration, differentiation and function. Nature Reviews Immunology 13(5):309-20, 2013. e-Pub 2013. PMID: 23598650.
- Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. Journal Immunology 188(10):4866-75, 2012. e-Pub 2012. PMID: 22504644.
Grant & Contract Support
| Date: | 2022 - 2027 |
| Title: | Identifying the contributions of timing and location in T cell dysfunction in tumors |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Investigator |
| ID: | RR22086 |
| Date: | 2021 - 2026 |
| Title: | The ontogeny and function of CD8 T cells in lung cancer |
| Funding Source: | NIH/NCI |
| Role: | Investigator |
| ID: | K08 CA256044 |
Patient Reviews
CV information above last modified January 24, 2024