Jean Gautier, PHD, Dr.Sc.
Department of Epigenetics and Molecular Carcinogenesis, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor and Chair, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 1988 | University of Toulouse, Toulouse, Occitania, FR, Developmental Biology, Dr. Sc, (Doctorat d’état es sciences) |
| 1983 | University of Toulouse, Toulouse, FR, Developmental Biology, PhD |
| 1978 | University of Toulouse, Toulouse, FR, Biology, MS |
Postgraduate Training
| 1990-1992 | American Cancer Society Senior Postdoctoral Fellow, University of California San Francisco, California |
| 1988-1989 | Postdoctoral Fellow, University of Colorado Health Sciences Center, Colorado |
| 1987-1987 | Visiting Scientist, Indiana University, Bloomington, Indiana |
| 1983-1984 | Visiting Scientist, Free University of Brussels, Brussels |
Experience & Service
Faculty Academic Appointments
Adjunct Professor, Department of Genetics and Development, Columbia University, 2025 - 2026
Professor, Department of Genetics and Development, Columbia University Medical Center, New York, New York, 2008 - 2025
Associate Professor, Department of Genetics and Development, Columbia University Medical Center, New York City, New York, 2002 - 2008
Assistant Professor, Department of Genetics and Development, Department of Dermatology, Columbia University Medical Center, New York, New York, 1995 - 2002
Group Leader, Associate Member, Roche Institute of Molecular Biology, Nutley, New Jersey, 1993 - 1995
Group Leader, Centre National de la Recherche Scientifique URA 671, Nice, 1992 - 1993
Administrative Appointments/Responsibilities
Director, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 2022 - 2025
Chair, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 2020 - 2025
Co-leader, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 2019 - 2025
Associate Director for Research, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, 2017 - 2019
Leader, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, 2009 - 2019
Other Professional Positions
Permanent research scientist position as “Directeur de Recherches II”, Centre National de la Recherche Scientifique, 1992 - 2024
Permanent research scientist position as “Chargé de Recherches I”, Centre National de la Recherche Scientifique, 1988 - 1992
Permanent research scientist position as "Chargé de Recherches II, Centre National de la Recherche Scientifique, 1984 - 1988
Intramural Institutional Committee Activities
Member, Executive Committee of the Faculty Council of the School of Medicine, Columbia University Medical Center, 1998 - 2000
Extramural Institutional Committee Activities
HICCC representative, Basic Sciences Chair Meetings, Columbia University, 2020 - 2022
Member, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 2008 - 2025
Member, Faculty search committee Institute for Cancer Genetics, Columbia University Medical Center, 2008 - 2025
Member, Faculty Council of the School of Medicine, Columbia University Medical Center, 1996 - 2025
Member, Executive Committee of the Department of Dermatology, Columbia University Medical Center, 1995 - 2002
Member, Graduate Program in Biological Sciences, Columbia University
Member, Molecular Pharmacology and Therapeutics Graduate Program, Columbia University
Member, Medical Scientist Training Program, Columbia University
Member, Cellular Molecular and Biomedical Studies Integrated Graduate Program, Columbia University
Member, Genetics and Development Graduate Program, Columbia University
Member, Biochemistry and Molecular Biophysics Graduate Program, Columbia University in the City of New York
Honors & Awards
| 2024 - Present | Fellow of the American Association for the Advancement of Science (AAAS) |
| 2024 | HICCC Trainee Associate Member Mentor of the year |
| 2021 | The Levin Lecture, Dana Farber Cancer Institute |
| 2018 - 2024 | STARR Cancer Consortium, Scientific Review Board |
| 2016 | UICC Yamagiwa-Yoshida Memorial International Cancer Study Fellow |
| 2016 | Mayent – Rothschild Lecture, Curie Institute, Paris, France |
| 2015 - 2016 | Mayent – Rothschild Fellow, Curie Institute, France |
| 2015 | Outstanding Investigator Award, National Cancer Institute |
| 2002 | Dr. Harold and Golden Lamport Award for Excellence in Basic Science Research |
| 1997 - 2001 | Department of Defense – Breast Cancer Research Program Career Development Award |
| 1997 - 2001 | Irma T. Hirschl Scholar Award |
| 1996 - 1999 | Mallinckrodt Foundation Scholar |
| 1993 - 1995 | ATIPE, CNRS award, starting grant package (France) |
| 1990 - 1992 | Senior Post-doctoral Fellowship, American Cancer Society, University of California, San Francisco |
| 1989 - Present | EMBO Fellowship, Oxford University, Advisor: Prof. Paul Nurse (Nobel Laureate, Physiology and Medicine, 2001) |
| 1989 | Bronze medal CNRS, Developmental Biology, Life Sciences Section (France) |
| 1982 | IAESTE (International Association for Exchange of Student for Technical Experience) Fellow |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2023. Invited Speaker. Philadelphia, Pennsylvania, US.
- 2015. Invited Speaker. Genome Integrity Discussion Group. New York, New York, US.
- 2013. Invited Speaker. Philadelphia, Pennsylvania, US.
- 2013. Invited Speaker. New York, New York, US.
- 2012. Invited Speaker. New York, New York, US.
- 2010. Invited Speaker. Department of Hematology/Oncology. Ithaca, New York, US.
- 2006. Invited Speaker. Department of Molecular Biology. New York, New York, US.
- 2004. Invited Speaker, US.
- 2003. Invited Speaker. Invited. Genome Stability Meeting, US.
Regional Presentations
- 2006. Invited Speaker. Department of Molecular Biology. Ithaca, New York, US.
- 2006. Invited Speaker. Department of Therapeutic radiology. New Haven, Connecticut, US.
- 2005. Invited Speaker. Department of Radiation Oncology. Baltimore, Maryland, US.
- 2004. Invited Speaker. Invited, US.
- 2003. Invited Speaker. Invited. Philadelphia, Pennsylvania, US.
National Presentations
- 2025. Invited Speaker. Cytoskeletal Structure, Dynamics, and Function, US.
- 2024. Invited Speaker. American Society for Cell Biology. San Diego, California, US.
- 2024. Invited Speaker. Genetic Recombination & Genome Rearrangements. Tucson, Arizona, US.
- 2023. Invited Speaker. Waltham, Massachusetts, US.
- 2023. Invited Speaker. Boston, Massachusetts, US.
- 2021. Invited Speaker. NCI Seminar Series, US.
- 2021. Invited Speaker. Seminars in Oncology, Levin Lecture,, US.
- 2019. Invited Speaker. NCI Workshop: Chromatin and Cell Fate Decision in Development, Aging and Cancer. Frederick, Maryland, US.
- 2019. Invited Speaker. NCI Workshop: Liquid phase separation as a cellular regulatory mechanism: State of the science and implications for cancer research. Frederick, Maryland, US.
- 2019. Invited Speaker. Inaugural Meeting of the National Cancer Institute’s Outstanding Investigators Award, US.
- 2018. Invited Speaker. San Diego, California, US.
- 2018. Invited Speaker. NCI Workshop: The Molecular Bases of the BRCA Phenotype in Human Cancer. Frederick, Maryland, US.
- 2017. Invited Speaker. Denver, Colorado, US.
- 2017. Invited Speaker. Recombination and Genetic Rearrangements. Steamboat Springs, Colorado, US.
- 2017. Invited Speaker. Dallas, Texas, US.
- 2016. Invited Speaker. Tucson, Arizona, US.
- 2016. Invited Speaker. Los Angeles, California, US.
- 2016. Invited Speaker. San Francisco, California, US.
- 2016. Invited Speaker. Invited. Houston, Texas, US.
- 2015. Invited Speaker. The Past and Future of Cellular, Molecular, and Systems Biology. Cambridge, Massachusetts, US.
- 2015. Invited Speaker. AACR: MYC: from biology to therapy. San Diego, California, US.
- 2015. Invited Speaker. Genetic Recombination & Genome. Steamboat Springs, Colorado, US.
- 2013. Invited Speaker. Boston, US.
- 2013. Invited Speaker. Mammalian DNA Repair. Ventura, California, US.
- 2013. Invited Speaker. 25rd Fanconi Anemia Symposium, US.
- 2013. Invited Speaker. Athens, Georgia, US.
- 2013. Invited Speaker. St Louis, Missouri, US.
- 2012. Invited Speaker. Radiation Oncology Grand Rounds. Detroit, Michigan, US.
- 2012. Invited Speaker. West Lafayette, Indiana, US.
- 2011. Invited Speaker. Keystone Symposium. Snowmass, Colorado, US.
- 2011. Invited Speaker. Rochester, Minnesota, US.
- 2011. Invited Speaker. John Anderson Symposium. Charlottesville, Virginia, US.
- 2011. Invited Speaker. Invited. Denver Cell Cycle Symposium. Denver, Colorado, US.
- 2011. Invited Speaker. Invited. Houston, Texas, US.
- 2011. Invited Speaker. Genetic Recombination and Genome Rearrangements. Steamboat Springs, Colorado, US.
- 2011. Invited Speaker. DNA Replication and Recombination. Taos, New Mexico, US.
- 2010. Invited Speaker. 22rd Fanconi Anemia Scientific Symposium. Minneapolis, Minnesota, US.
- 2009. Invited Speaker. Albuquerque, New Mexico, US.
- 2009. Invited Speaker. 21st Fanconi Anemia Scientific Symposium. Portland, US.
- 2009. Invited Speaker. Department of Cell Biology. Saint Louis, Missouri, US.
- 2009. Invited Speaker. Tampa, Florida, US.
- 2009. Invited Speaker. Genetic Recombination and Genome Rearrangements. Snowmass, Colorado, US.
- 2009. Invited Speaker. Cell Growth and Proliferation. Waterville, Maine, US.
- 2007. Invited Speaker. Genetic Recombination and Genome Rearrangements. Snowmass, Colorado, US.
- 2007. Invited Speaker. Tampa, Florida, US.
- 2006. Invited Speaker. Department of Radiation Biology. New York, New York, US.
- 2006. Invited Speaker. Department of Biology. Nashville, Tennessee, US.
- 2005. Invited Speaker. Department of Molecular Genetics. Austin, Texas, US.
- 2005. Invited Speaker. Department of Pharmacology. Madison, Wisconsin, US.
- 2005. Session Chair. DNA Replication and Recombination. Taos, New Mexico, US.
- 2005. Invited Speaker. Department of Molecular Biology. Dallas, Texas, US.
- 2004. Session Chair. Panelist. DNA Replication and Genome Stability, US.
- 2004. Invited Speaker. Invited. Department of Molecular Medicine, US.
- 2004. Invited Speaker. Invited, US.
- 2003. Invited Speaker. Genetic Recombination and Genome Rearrangements. Snowmass, Colorado, US.
- 2003. Invited Speaker. Mammalian DNA Repair. Ventura, California, US.
- 2003. Invited Speaker. Second Messengers and Protein Phosphorylation, New Hampshire, US.
- 2003. Invited Speaker. Invited. Houston, Texas, US.
- 2003. Departmental Seminar. Invited, US.
- 2003. Invited Speaker. Invited. Department of Cell Biology, US.
- 2003. Invited Speaker. Invited. DNA Replication and Genome Stability. La Jolla, California, US.
International Presentations
- 2024. Session Chair. DNA repair pathways as targets for cancer therapy, MT.
- 2024. Invited Speaker. Nuclear Actin Symposium. Abu-Dhabi, AE.
- 2022. Invited Speaker. Nuclear Actin Symposium. Szeged, HU.
- 2020. Invited Speaker. First CABIMER International Workshop: “Trends in Genome Integrity & Chromosome Dynamics”. Sevilleja de la Jara, ES.
- 2019. Invited Speaker. Fusion Conference: Spatial genome organization, BS.
- 2017. Invited Speaker. Ataxia-Telangiectasia Workshop. Milan, IT.
- 2017. Invited Speaker. Fusion conference: Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference. Cancun, MX.
- 2017. Invited Speaker. Chromatin organization. Whistler, CA.
- 2016. Invited Speaker. Orsay, FR.
- 2016. Invited Speaker. DINGO meeting: replication stress, genetic instability and cancer. Paris, FR.
- 2016. Invited Speaker. Paris, FR.
- 2016. Invited Speaker. Institute of Integrative Biology of the Cell. Gif-sur-Yvette, FR.
- 2016. Invited Speaker, GB.
- 2016. Invited Speaker. Transcription-Replication Crosstalk and Genome Instability. Roscoff, FR.
- 2016. Invited Speaker. IFOM. Milan, IT.
- 2015. Invited Speaker. Curie Institute, Paris, Mayent-Rothschild Seminar. Paris, FR.
- 2015. Invited Speaker. IGBMC. Strasbourg, FR.
- 2015. Invited Speaker. Genome Instability and Cancer: new ideas. Paris, FR.
- 2014. Invited Speaker. ABCAM Meeting, KN.
- 2014. Invited Speaker. Peking, CN.
- 2014. Invited Speaker. Gordon Conference:Mutagenesis. Gerona, PH.
- 2013. Invited Speaker. FEBS Workshop, NER and ICL Repair, SK.
- 2013. Invited Speaker. Brno, CZ.
- 2012. Invited Speaker. 14th AT Workshop. Delhi, IN.
- 2012. Invited Speaker. Recombination Mechanism and Genome Instability. Jerez de la Frontera, ES.
- 2011. Invited Speaker. 23rd Fanconi Anemia Symposium. Barcelona, ES.
- 2010. Invited Speaker. International Ataxia-Telangieactasia Workshop. Los Angeles, US.
- 2010. Invited Speaker, GB.
- 2010. Invited Speaker. International Xenopus Conference. Lake Louise, CA.
- 2008. Invited Speaker. IRCM. Montreal, CA.
- 2008. Invited Speaker. International Ataxia-Telangiectasia Workshop. Kyoto, JP.
- 2007. Invited Speaker. Cancer Models and Mechanisms. Les Diablerets, CH.
- 2007. Invited Speaker. Cancer Colloquium on Origins of Cancer. St Andrews.
- 2007. Invited Speaker. 2nd International Gene Center-SFB 646 Symposium. Munich, DE.
- 2007. Invited Speaker. CNIO Cancer Conference: Links between cancer, replication stress and genomic integrity. Madrid, ES.
- 2007. Invited Speaker. VI International Symposium on Cell Death and Aging. Paris, FR.
- 2007. Invited Speaker - Plenary Lecture. Giens, FR.
- 2006. Invited Speaker. International Ataxia-Telangiectasia Workshop. Banff, CA.
- 2005. Session Chair. Benzon Symposium on Genome Stability. Copenhagen, DK.
- 2005. Session Chair. International Ataxia-Telangiectasia Workshop. Lago Maggiore, IT.
- 2004. Invited Speaker. Genome Stability. Roscoff, FR.
- 2004. Invited Speaker. Recombination, Replication and Genome Stability. Seilhac, FR.
- 2004. Invited Speaker. IFOM Conference. Milan, IT.
- 2003. Invited Speaker. Invited. Cell Cycle. Roscoff, FR.
- 2003. Invited Speaker. Invited. 8th International Ataxia-Telangiectasia Workshop. Frazier Island, AU.
- 2003. Invited Speaker. Invited. Symposium on Genome Stability. Kyoto, JP.
- 2003. Keyote Speaker. Invited. Australian Cell Cycle Conference. Melbourne, AU.
Grant & Contract Support
| Date: | 2027 - 2032 |
| Title: | Transcription-driven genome instability, DNA repair and cancer |
| Funding Source: | NIH |
| Role: | PI |
| ID: | R01CA304149-01A1 |
| Date: | 2025 - 2030 |
| Title: | Spatial Dynamics of Transcription-Driven Genome Instability in Cancer Development and Therapy |
| Funding Source: | CPRIT |
| Role: | PI |
| ID: | RR250073 |
| Date: | 2025 - 2029 |
| Title: | Transcription-Driven Genome Instability, DNA repair and cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | R01CA304149 |
| Date: | 2024 - 2029 |
| Title: | Maintenance of genome stability in 3D |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 4R01CA287287-03 (Columbia through 6/1/25; UTMDACC from 6/2/25 - Current) |
| Date: | 2016 - 2018 |
| Title: | Cancer Biology Training Grant |
| Funding Source: | NIH/NCI |
| Role: | Contact PI/Project Leader |
| ID: | T32CA009503 |
| Date: | 2015 - 2023 |
| Title: | DNA Repair and Genomic Instability in Cancer Development and Therapy |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R35CA197606 |
| Date: | 2014 - 2025 |
| Title: | DNA double strand break repair, chromosome translocations and cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | P01CA174653 |
| Date: | 2012 - 2016 |
| Title: | Studies of DNA interstrand crosslink repair to improve crosslinking drug therapie (Rolled into R35CA197606) |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA167826 (Rolled in to R35CA197606) |
| Date: | 2011 - 2012 |
| Title: | Evaluating Interstrand Crosslink (ICL) Repair in Triple-Negative Breast Cancers to Guide Chemotheraphy |
| Funding Source: | Department of Defense |
| Role: | PI |
| ID: | W81XWH-11-1-0265-Proposal Number: BC103035 |
| Date: | 2009 - 2011 |
| Title: | Regulation of the DNA damage response by the MRN-ATM pathway |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA092245-08S1 |
| Date: | 2009 - 2010 |
| Title: | Regulation of DNA Replication by MCM Proteins |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01GM077495-02S1 |
| Date: | 2008 - 2025 |
| Title: | Cancer Center Support Grant |
| Funding Source: | NIH/NCI |
| Role: | Co Leader |
| ID: | P30-CA013696 |
| Date: | 2008 - 2011 |
| Title: | Coordination of BRCA1/BARD1- and MRE11/RAD50/NBS1-dependent DNA transactions in breast tumor suppression |
| Funding Source: | Department of Defense/BCRP |
| Role: | PI |
| ID: | W81XWH-08-1-0426; BC073889 |
| Date: | 2008 - 2013 |
| Title: | Regulation of DNA Replication by MCM Proteins |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | R01GM077495 |
| Date: | 2005 - 2006 |
| Title: | Tumor Suppression by BRCA1: A Critical Role at DNA Replication Forks? |
| Funding Source: | Department of Defense |
| Role: | PI |
| ID: | W81XWH-05-1-0494; BC045534 |
| Date: | 2002 - 2007 |
| Title: | Probing the DNA Damage Response In Vitro |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA095866 |
| Date: | 2002 - 2016 |
| Title: | Regulation of the DNA damage response by ATM-MRN pathway |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA092245 (Rolled into R35CA197606) |
| Date: | 1999 - 2003 |
| Title: | Cell Cycle Control by the Camp PKA Signal Transduction |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | R01GM056781 |
| Date: | 1997 - 2001 |
| Title: | The Functional Role of the Ataxia-Telangiectasia Gene |
| Funding Source: | Department of Defense |
| Role: | PI |
| ID: | DAMD17-97-1-7071; BC961806 |
| Date: | 1997 - 2000 |
| Title: | Grant RPG-99-040-01-CCG |
| Funding Source: | American Cancer Society |
| Role: | PI |
| ID: | RPG-99-040-01-CCG |
Selected Publications
Peer-Reviewed Articles
- Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J. UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks. DNA Repair (Amst) 143:103771, 2024. e-Pub 2024. PMID: 39383571.
- Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J. Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA. bioRxiv, 2024. e-Pub 2024. PMID: 37214867.
- Min, J, Zhao, J, Zagelbaum, JA, Lee, J, Takahashi, S, Cummings, P, Schooley, A, Dekker, J, Gottesman, M, Rabadan, R, Gautier, J. Mechanisms of insertions at a DNA double-strand break. Molecular cell 83(14):2434-2448.e7, 2023. e-Pub 2023. PMID: 37402370.
- Zagelbaum, JA, Gautier, J. Double-strand break repair and mis-repair in 3D. DNA Repair 121, 2023. e-Pub 2023. PMID: 36436496.
- Zagelbaum, JA, Schooley, A, Zhao, J, Schrank, B, Callen, E, Zha, S, Gottesman, M, Nussenzweig, A, Rabadan, R, Dekker, J, Gautier, J. Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural and Molecular Biology 30(1):99-106, 2023. e-Pub 2023. PMID: 36564591.
- Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, A Ferrando A. Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair. Blood 139(23):3418-3429, 2022. e-Pub 2022. PMID: 35338774.
- Wang XS, Menolfi D, Wu-Baer F, Fangazio M, Meyer SN, Shao Z, Wang Y, Zhu Y, Lee BJ, Estes VM, Cupo OM, Gautier J, Pasqualucci L, Dalla-Favera R, Baer R, Zha S. DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice. Proc Natl Acad Sci U S A 118(38), 2021. e-Pub 2021. PMID: 34521752.
- Prakash R, Sandoval T, Morati F, Zagelbaum JA, Lim PX, White T, Taylor B, Wang R, Desclos ECB, Sullivan MR, Rein HL, Bernstein KA, Krawczyk PM, Gautier J, Modesti M, Vanoli F, Jasin M. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nat Commun 12(1):4255, 2021. e-Pub 2021. PMID: 34253720.
- Tao Y, Aparicio T, Li M, Leong KW, Zha S, Gautier J. Inhibition of DNA replication initiation by silver nanoclusters. Nucleic Acids Res 49(9):5074-5083, 2021. e-Pub 2021. PMID: 33905520.
- Sato M, Liebau RC, Liu Z, Liu L, Rabadan R, Gautier J. The UVSSA complex alleviates MYC-driven transcription stress. J Cell Biol 220(2), 2021. e-Pub 2021. PMID: 33404608.
- Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo OM, Rabadan R, Gautier J, Baer R, Zha S. CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining. Proc Natl Acad Sci U S A 117(41):25700-25711, 2020. e-Pub 2020. PMID: 32989150.
- Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry. ACS Appl Mater Interfaces 12(20):22499-22506, 2020. e-Pub 2020. PMID: 32337977.
- Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S. CtIP is essential for early B cell proliferation and development in mice. J Exp Med 216(7):1648-1663, 2019. e-Pub 2019. PMID: 31097467.
- Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559(7712):61-66, 2018. e-Pub 2018. PMID: 29925947.
- Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Scharer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J. Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep 21(5):1375-1385, 2017. e-Pub 2017. PMID: 29091773.
- Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol 212(4):399-408, 2016. e-Pub 2016. PMID: 26880199.
- Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva JM, Gautier J. MYC is a critical target of FBXW7. Oncotarget 6(5):3292-305, 2015. e-Pub 2015. PMID: 25669969.
- Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J. Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep 3(5):1629-39, 2013. e-Pub 2013. PMID: 23643534.
- Rozier L, Guo Y, Peterson S, Sato M, Baer R, Gautier J, Mao Y. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell 49(6):1097-107, 2013. e-Pub 2013. PMID: 23434370.
- Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J. Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell 49(4):657-67, 2013. e-Pub 2013. PMID: 23273981.
- Williams HL, Gottesman ME, Gautier J. Replication-independent repair of DNA interstrand crosslinks. Mol Cell 47(1):140-7, 2012. e-Pub 2012. PMID: 22658724.
- Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J. Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol 194(5):705-20, 2011. e-Pub 2011. PMID: 21893598.
- Lefebvre C, Rajbhandari P, Alvarez MJ, Bandaru P, Lim WK, Sato M, Wang K, Sumazin P, Kustagi M, Bisikirska BC, Basso K, Beltrao P, Krogan N, Gautier J, Dalla-Favera R, Califano A. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol 6:377, 2010. e-Pub 2010. PMID: 20531406.
- Kurth I, Gautier J. Origin-dependent initiation of DNA replication within telomeric sequences. Nucleic Acids Res 38(2):467-76, 2010. e-Pub 2010. PMID: 19906732.
- Di Virgilio M, Ying CY, Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) 8(11):1311-20, 2009. e-Pub 2009. PMID: 19709933.
- Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell 35(5):704-15, 2009. e-Pub 2009. PMID: 19748363.
- Roques C, Coulombe Y, Delannoy M, Vignard J, Grossi S, Brodeur I, Rodrigue A, Gautier J, Stasiak AZ, Stasiak A, Constantinou A, Masson JY. MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J 28(16):2400-13, 2009. e-Pub 2009. PMID: 19609304.
- Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol 16(8):819-24, 2009. e-Pub 2009. PMID: 19633668.
- Wang LC, Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) 7(12):1973-81, 2008. e-Pub 2008. PMID: 18786657.
- Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453(7195):677-81, 2008. e-Pub 2008. PMID: 18449195.
- Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 4(2):119-25, 2008. e-Pub 2008. PMID: 18176557.
- Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature 448(7152):445-51, 2007. e-Pub 2007. PMID: 17597761.
- Bhaskara V, Dupre A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT. Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell 25(5):647-61, 2007. e-Pub 2007. PMID: 17349953.
- Dupre A, Boyer-Chatenet L, Gautier J. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 13(5):451-7, 2006. e-Pub 2006. PMID: 16622404.
- Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME. Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol 26(2):425-37, 2006. e-Pub 2006. PMID: 16382135.
- Ying CY, Gautier J. The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. EMBO J 24(24):4334-44, 2005. e-Pub 2005. PMID: 16369567.
- Di Virgilio M, Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol 171(5):765-71, 2005. e-Pub 2005. PMID: 16330708.
- Eyers PA, Liu J, Hayashi NR, Lewellyn AL, Gautier J, Maller JL. Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem 280(26):24339-46, 2005. e-Pub 2005. PMID: 15860459.
- Yeo W, Gautier J. XNGNR1-dependent neurogenesis mediates early neural cell death. Mech Dev 122(5):635-44, 2005. e-Pub 2005. PMID: 15817221.
- Shechter D, Gautier J. ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle 4(2):235-8, 2005. e-Pub 2005. PMID: 15655372.
- Gautier J, Delmotte F, Roulliay M, Bridou F, Ravet MF, Jerome A. Study of normal incidence of three-component multilayer mirrors in the range 20-40 nm. Appl Opt 44(3):384-90, 2005. e-Pub 2005. PMID: 15717828.
- Giordano-Coltart J, Ying CY, Gautier J, Hurwitz J. Studies of the properties of human origin recognition complex and its Walker A motif mutants. Proc Natl Acad Sci U S A 102(1):69-74, 2005. e-Pub 2005. PMID: 15618391.
- Shechter D, Ying CY, Gautier J. DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem 279(44):45586-93, 2004. e-Pub 2004. PMID: 15326181.
- O'Shaughnessy RF, Yeo W, Gautier J, Jahoda CA, Christiano AM. The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol 123(4):613-21, 2004. e-Pub 2004. PMID: 15373764.
- Shechter D, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. Proc Natl Acad Sci U S A 101(30):10845-6, 2004. e-Pub 2004. PMID: 15263078.
- Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 6(7):648-55, 2004. e-Pub 2004. PMID: 15220931.
- Costanzo V, Paull T, Gottesman M, Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol 2(5):E110, 2004. e-Pub 2004. PMID: 15138496.
- Yeo W, Gautier J. A role for programmed cell death during early neurogenesis in xenopus. Dev Biol 260(1):31-45, 2003. e-Pub 2003. PMID: 12885553.
- Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 11(1):203-13, 2003. e-Pub 2003. PMID: 12535533.
- Kim AL, Gautier J, Bickers DR, Athar M. Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas. Biochem Biophys Res Commun 298(3):377-82, 2002. e-Pub 2002. PMID: 12413951.
- Kim AL, Athar M, Bickers DR, Gautier J. Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53. J Invest Dermatol 118(5):818-24, 2002. e-Pub 2002. PMID: 11982759.
- Kim AL, Athar M, Bickers DR, Gautier J. Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development. Photochem Photobiol 75(1):58-67, 2002. e-Pub 2002. PMID: 11837328.
- D'Angiolella V, Costanzo V, Gottesman ME, Avvedimento EV, Gautier J, Grieco D. Role for cyclin-dependent kinase 2 in mitosis exit. Curr Biol 11(15):1221-6, 2001. e-Pub 2001. PMID: 11516956.
- Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell 8(1):137-47, 2001. e-Pub 2001. PMID: 11511367.
- Athar M, Kim AL, Ahmad N, Mukhtar H, Gautier J, Bickers DR. Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53. Biochem Biophys Res Commun 277(1):107-11, 2000. e-Pub 2000. PMID: 11027648.
- Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell 6(3):649-59, 2000. e-Pub 2000. PMID: 11030344.
- Shechter DF, Ying CY, Gautier J. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein. J Biol Chem 275(20):15049-59, 2000. e-Pub 2000. PMID: 10747908.
- Romanowski P, Marr J, Madine MA, Rowles A, Blow JJ, Gautier J, Laskey RA. Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex. J Biol Chem 275(6):4239-43, 2000. e-Pub 2000. PMID: 10660590.
- Bao J, Talmage DA, Role LW, Gautier J. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. Development 127(2):425-35, 2000. e-Pub 2000. PMID: 10603358.
- Robertson K, Hensey C, Gautier J. Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development. Oncogene 18(50):7070-9, 1999. e-Pub 1999. PMID: 10597308.
- Costanzo V, Avvedimento EV, Gottesman ME, Gautier J, Grieco D. Protein kinase A is required for chromosomal DNA replication. Curr Biol 9(16):903-6, 1999. e-Pub 1999. PMID: 10469595.
- Roberts BT, Ying CY, Gautier J, Maller JL. DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase. Proc Natl Acad Sci U S A 96(6):2800-4, 1999. e-Pub 1999. PMID: 10077591.
- Hensey C, Gautier J. Developmental regulation of induced and programmed cell death in Xenopus embryos. Ann N Y Acad Sci 887:105-19, 1999. e-Pub 1999. PMID: 10668468.
- Hensey C, Gautier J. Programmed cell death during Xenopus development: a spatio-temporal analysis. Dev Biol 203(1):36-48, 1998. e-Pub 1998. PMID: 9806771.
- Sible JC, Erikson E, Hendrickson M, Maller JL, Gautier J. Developmental regulation of MCM replication factors in Xenopus laevis. Curr Biol 8(6):347-50, 1998. e-Pub 1998. PMID: 9512418.
- Hensey C, Gautier J. A developmental timer that regulates apoptosis at the onset of gastrulation. Mech Dev 69(1-2):183-95, 1997. e-Pub 1997. PMID: 9486540.
- Hendrickson M, Madine M, Dalton S, Gautier J. Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex. Proc Natl Acad Sci U S A 93(22):12223-8, 1996. e-Pub 1996. PMID: 8901561.
- Gabrielli BG, Roy LM, Gautier J, Philippe M, Maller JL. A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2. J Biol Chem 267(3):1969-75, 1992. e-Pub 1992. PMID: 1309805.
- Gautier J, Maller JL. Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation. EMBO J 10(1):177-82, 1991. e-Pub 1991. PMID: 1824935.
- Roy LM, Singh B, Gautier J, Arlinghaus RB, Nordeen SK, Maller JL. The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product. Cell 61(5):825-31, 1990. e-Pub 1990. PMID: 2140529.
- Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller JL. Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60(3):487-94, 1990. e-Pub 1990. PMID: 1967981.
- Langan TA, Gautier J, Lohka M, Hollingsworth R, Moreno S, Nurse P, Maller J, Sclafani RA. Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells. Mol Cell Biol 9(9):3860-8, 1989. e-Pub 1989. PMID: 2550805.
- Gautier J, Matsukawa T, Nurse P, Maller J. Dephosphorylation and activation of Xenopus p34cdc2 protein kinase during the cell cycle. Nature 339(6226):626-9, 1989. e-Pub 1989. PMID: 2543932.
- Gautier J, Norbury C, Lohka M, Nurse P, Maller J. Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell 54(3):433-9, 1988. e-Pub 1988. PMID: 3293803.
- Gautier J, Tencer R. Involvement of the cytoskeleton in early grey crescent formation in axolotl oocytes. Rouxs Arch Dev Biol 196(5):316-320, 1987. e-Pub 1987. PMID: 28305553.
- Gautier J, Tencer R. Changes in patterns of protein synthesis in axolotl oocytes during progesterone-induced maturation. J Embryol Exp Morphol 92:103-13, 1986. e-Pub 1986. PMID: 3723056.
- Gautier J, Beetschen JC. Inhibition of protein synthesis elicits early grey crescent formation in the axolotl oocyte. Wilehm Roux Arch Dev Biol 192(3-4):196-199, 1983. e-Pub 1983. PMID: 28305127.
- Gautier J, Bird DM, Ng Kwai Hang KF. Plasma protein patterns in captive American kestrels. Comp Biochem Physiol A Comp Physiol 75(2):163-6, 1983. e-Pub 1983. PMID: 6135535.
Review Articles
- Ahmed, A, Kato, N, Gautier, J. Replication-Independent ICL Repair. Journal of Molecular Biology 436(13), 2024. e-Pub 2024. PMID: 38763228.
- Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice and cancer. DNA Repair (Amst) 19:169-75, 2014. e-Pub 2014. PMID: 24746645.
- Costanzo V, Gautier J. Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. Cell Cycle 2(1):17, 2003. e-Pub 2003. PMID: 12695677.
- Greenwood J, Costanzo V, Robertson K, Hensey C, Gautier J. Responses to DNA damage in Xenopus: cell death or cell cycle arrest. Novartis Found Symp 237:221-30; discussion 230-4, 2001. e-Pub 2001. PMID: 11444046.
- Maller Jl, Gautier J, Langan TA, Lohka MJ, Shenoy S, Shalloway D, Nurse P. Maturation-promoting factor and the regulation of the cell cycle. J Cell Sci Suppl 12:53-63, 1989. e-Pub 1989. PMID: 2699738.
Other Articles
- Gautier J, Ahmed A, Kato N Replication-independent ICL repair: from chemotherapy to cell homeostasis 436(13):168618, 2024. PMID: 38763228.
- Dominguez-Sola, D, Ying, CY, Grandori, C, Ruggiero, L, Chen, B, Li, M, Galloway, D, Gu, W, Gautier, J, Dalla-Favera, R Author Correction. Nature 619(7969):E39, 2023. PMID: 37386298.
- Gautier J, Schrank B Assembling Nuclear Domains: Lessons from DNA repair. Jurnal Cell Biology 218(8)(5):2444-2455, 2019. PMID: 31324649.
- Gautier J, Dominguez-Sola D MYC and the control of DNA Replication. Cold Spring Harb Perspect Med 6(4):a014423, 2014. PMID: 24890833.
- Gautier J, Symington LS Double strand breaks end resection and repair pathway choice. Annual Review of Genetics 45:247-271, 2011. PMID: 21910633.
- Gautier J, Wang, LC The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Critical Reviews In Biochemistry & Molecular Biology 45(5):424-39, 2010. PMID: 20807115.
- Gautier J, Peterson S, Wang L, Robertson K, Torchon G, Ouerfelli O Corrected structure of mirin, a small molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nature Chemical Biology 5:130, 2009.
- Gautier J, Shecter D MCM proteins and checkpoint kinases get together at the fork. Proceeding National of the Academy Sciences 101:10845-6, 2004.
- Gautier J The role of the germinal vesicle for maturation-promoting factor activity in the Axolotl oocyte. Developmental Biology 123:483-486, 1987.
- Gautier J, Beetschen JC Heat-shock induced grey crescent in Axolotl oocytes and eggs: the role of gravity. Development 100:599-609, 1987.
- Gautier J, Bird D.M., Monpetit V Embryonic growth of american kestrels. The Auk 101:392-396, 1984.
- Gautier J, Beetschen JC La formation du croissant gris induite dans l'ovocyte d'axolotl en cours de maturation, depends de facteurs d'origine nucleaire. Comptes Rendus Academie Sciences Paris Ser III 296:815-818, 1983.
- Gautier J, Williams H, Gottesman M.E. The differences between ICL repair during and outside of S phase. Trends in Biochemical Sciences(38):386-393. PMID: 23830640.
- Gautier J, Aparicio T BRCA1-CtIP interaction in the repair of DNA double-strand breaks. Molecular Cell Oncology. PMID: 27652321.
- Gautier J. PMID: 1913817.
- Gautier J, Min J Chromatin compartments at DNA double-stranded breaks. Cell Research(34(5)):337-338. PMID: 38097773.
Abstracts
- Wolf MA, Gautier J. Physiopathologie et traitement curatif des dyskinesies tardives. Encephale 13(5):301-8, 1987. e-Pub 1987. PMID: 2892663.
- Gautier J, Beetschen JC. La formation du croissant gris, induite dans l'ovocyte d'axolotl en cours de maturation, depend de facteurs d'origine nucleaire. C R Seances Acad Sci III 296(17):815-8, 1983. e-Pub 1983. PMID: 6412990.
Book Chapters
- Gautier J, Aparicio T. DNA Damage Response in Xenopus laevis Cell-Free Extracts. In: Methods Molecular Biology. 2267, 103-144, 2021.
- Gautier J, Srinivasan SV. Studies of Cell Cycle Checkpoints using Xenopus cell-free extracts. In: Methods Molecular Biology, 119-158, 2011.
- Costanzo V, Robertson K, Gautier J. Xenopus cell-free extracts to study the DNA damage response. In: Methods Mol Biol, 213-27, 2004.
- Costanzo V, Gautier J. Xenopus cell-free extracts to study DNA damage checkpoints. In: Methods Mol Biol, 255-67, 2004.
- Costanzo V, Gautier J. Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. In: Cell Cycle, 17, 2003.
- Gautier J. The cdc25 Protein Tyrosine Phosphatase Family. In: Advances in Protein Phosphatases, 151-179, 1993.
- Solomon MJ, Gautier J, Lee T, Kirschner MW. Control of p34cdc2 activation. In: Cold Spring Harb Symp Quant Biol, 427-35, 1991.
- Gautier J, Beetschen JC. Involvement of the cytoskeleton in early gray crescent formation in axolotl oocyte: relationships with germinal vesicle breakdown. In: Prog Clin Biol Res, 403-6, 1986.
- Gautier J, Costanzo V, Greenwood J, Robertson K, Hensey C. Responses to DNA damage in Xenopus: cell death or cell cycle arrest. In: Novartis Foundation Symposium, 221-30.
- Gautier J, Hensey C. Developmental regulation of induced and programmed cell death in Xenopus embryos. In: Annals New York Academy Sciences.
- Gautier J, Hensey C. Regulation of cell cycle progression following DNA damage. In: Progress in Cell Cycle Research. Springer, 149-162.
Books (edited and written)
- Gautier J, Beetschen JC. A three-step scheme for gray crescent formation in the rotated axolotl oocyte, 1985.
Web Publications
- Aparicio T, Gautier J. More tasks for Dna2 in S-phase, 2012.
- Ben-Yehoyada M, Gautier J, Dupre A. The DNA damage response during an unperturbed S-phase, 2007.
- Greenwood J, Gautier J. From oogenesis through gastrulation: developmental regulation of apoptosis, 2005.
- Yeo W, Gautier J. Early neural cell death: dying to become neurons, 2004.
- Shechter D, Costanzo V, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates, 2004.
- Gautier J, Pal JK, Grossi de Sa MF, Beetschen JC, Scherrer K. Differential cytolocalization of prosomes in axolotl during oogenesis and meiotic maturation, 1988.
Patient Reviews
CV information above last modified September 09, 2026