Jeffrey H. Siewerdsen, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Lead, Focus Area Five, Surgical Data Sciences, Department of Institute for Data Science in Oncology, Division of Office of the President, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Adjunct Professor, Department of Bioengineering, Rice University, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | University of Michigan, Ann Arbor, MI, USA, PHD, Physics |
| 1994 | University of Michigan, Ann Arbor, MI, USA, MS, Physics |
| 1992 | University of Minnesota, Minneapolis, MN, USA, BA, Physics and Astronomy |
Experience & Service
Academic Appointments
John C. Malone Professor, Department of Biomedical Engineering with cross-appointment in Computer Science, Radiology, Neurosurgery, and the Armstrong Institute for Patient Safety and Quality, Johns Hopkins University, Baltimore, MD, 2018 - 2022
Professor, Department of Biomedical Engineering with cross-appointment in Computer Science, Radiology, Neurosurgery, and the Armstrong Institute for Patient Safety and Quality, Johns Hopkins University, Baltimore, MD, 2012 - 2018
Associate Professor, Department of (2009-12) Biomedical Engineering, (2010-12) Department of Computer Science, (2010-12) Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, 2009 - 2012
Senior Scientist, Division of Biophysics and Bio-imaging, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Ontario, 2007 - 2009
Associate Professor, Department of Radiation Oncology, Division of Medical Biophysics, University of Toronto, Ontario, 2007 - 2009
Scientist, Division of Biophysics and Bio-imaging, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Ontario, 2002 - 2007
Assistant Professor, Department of Medical Biophysics, Radiation Oncology, and Otolaryngology -Head and Neck Surgery, Division of Medical Biophysics, University of Toronto, Ontario, 2002 - 2007
Research Scientist, Division of Physics Division, William Beaumont Hospital, Royal Oak, MI, 1998 - 2002
Administrative Appointments/Responsibilities
Judge, Department of Trainee Research Symposium, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Panelist and Judge, Department of Texas BioDesign Teams Presentations, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Director of Surgical Data Science, Department of Surgical Data Science Program, Institute for Data Science in Oncology (IDSO), The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Vice-Chair for Clinical and Industry Collaboration, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MA, 2018 - 2022
Co-Director, Department of Carnegie Center for Surgical Innovation, Johns Hopkins University, Baltimore, MD, 2015 - 2022
Honors & Awards
| 2023 | Fellow, SPIE (International Society for Optics and Photonics) |
| 2022 | Distinguished Investigator Award, Academy for Radiology and Biomedical |
| 2021 | Imaging Research, Coalition for Imaging and Bioengineering Research (CIBR) SPIE Community Champion, International Society for Optics and Photonics |
| 2020 | The Spirit of Surgineering Award, Computer Assisted Radiology and Surgery |
| 2019 | The CDRH Director's Special Citation Award, Center for Devices in Radiological Health, FDA |
| 2018 | John C. Malone Professorship, Johns Hopkins University |
| 2016 | The Frost & Sullivan Award for New Product Innovation, Carestream Health |
| 2016 | Best New Radiology Device, Aunt Minnie Radiology News |
| 2016 | Fellow, American Institute for Medical and Biological Engineering |
| 2015 | Moses and Sylvia Greenfield Award, American Association of Physicists in Medicine |
| 2013 | Spine Technology of the Year, Orthopedics This Week |
| 2012 | Fellow, American Association of Physicists in Medicine |
| 2005 | Sylvia Fedoruk Award, Medical Physics |
| 2003 | Sylvia Fedoruk Award, Medical Physics |
| 2002 | Farrington-Daniels Award, American Association of Physicists in Medicine |
| 2001 | Sylvia Sorkin Greenfield Award, American Association of Physicists in Medicine |
| 1999 | Terwilliger Prize, University of Michigan |
| 1999 | Distinguished Dissertation Award, Rackham School of Graduate Studies |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Ding AS, Lu A, Li Z, Sahu M, Galaiya D, Siewerdsen JH, Unberath M, Taylor RH, Creighton FX. A self-configuring deep learning network for segmentation of temporal bone anatomy in cone-beam CT imaging. Otolaryngol Head Neck Surg. e-Pub 2023. PMID: 36883992.
- Zhang X, Sisniega A, Zbijewski WB, Lee J, Jones CK, Wu P, Han R, Uneri A, Vagdargi P, Helm PA, Luciano M, Anderson WS, Siewerdsen JH. Combining physics-based models with deep learning image synthesis and uncertainty in intraoperative cone-beam CT of the brain. Med Phys:1-18. e-Pub 2023. PMID: 36906915.
- Han R, Jones CK, Lee J, Wu P, Vagdargi P, Uneri A, Helm PA, Luciano M, Anderson WS, Siewerdsen JH. Deformable MR-CT image registration using an unsupervised, dual-channel network for neurosurgical guidance. Med Image Anal 75:102292, 2022. e-Pub 2021. PMID: 34784539.
- De Silva T, Vedula SS, Perdomo-Pantoja A, Vijayan R, Doerr SA, Uneri A, Han R, Ketcha MD, Skolasky RL, Witham T, Theodore N, Siewerdsen JH. SpineCloud: image analytics for predictive modeling of spine surgery outcomes. J Med Imaging (Bellingham) 7(3):031502, 2020. e-Pub 2020. PMID: 32090136.
- Zhang X, Uneri A, Webster Stayman J, Zygourakis CC, Lo SL, Theodore N, Siewerdsen JH. Known-component 3D image reconstruction for improved intraoperative imaging in spine surgery: A clinical pilot study. Med Phys 46(8):3483-3495, 2019. e-Pub 2019. PMID: 31180586.
- Reaungamornrat S, De Silva T, Uneri A, Vogt S, Kleinszig G, Khanna AJ, Wolinsky JP, Prince JL, Siewerdsen JH. MIND Demons: Symmetric Diffeomorphic Deformable Registration of MR and CT for Image-Guided Spine Surgery. IEEE Trans Med Imaging 35(11):2413-2424, 2016. e-Pub 2016. PMID: 27295656.
- Xu J, Sisniega A, Zbijewski W, Dang H, Stayman JW, Mow M, Wang X, Foos DH, Koliatsos VE, Aygun N, Siewerdsen JH. Technical assessment of a prototype cone-beam CT system for imaging of acute intracranial hemorrhage. Med Phys 43(10):5745, 2016. PMID: 27782694.
- Xu J, Sisniega A, Zbijewski W, Dang H, Stayman JW, Wang X, Foos DH, Aygun N, Koliatsos VE, Siewerdsen JH. Modeling and design of a cone-beam CT head scanner using task-based imaging performance optimization. Phys Med Biol 61(8):3180-207, 2016. e-Pub 2016. PMID: 27025783.
- Thawait GK, Demehri S, AlMuhit A, Zbijweski W, Yorkston J, Del Grande F, Zikria B, Carrino JA, Siewerdsen JH. Extremity cone-beam CT for evaluation of medial tibiofemoral osteoarthritis: Initial experience in imaging of the weight-bearing and non-weight-bearing knee. Eur J Radiol 84(12):2564-70, 2015. e-Pub 2015. PMID: 26388464.
- Dang H, Stayman JW, Sisniega A, Xu J, Zbijewski W, Wang X, Foos DH, Aygun N, Koliatsos VE, Siewerdsen JH. Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: application to high-quality head imaging. Phys Med Biol 60(16):6153-75, 2015. e-Pub 2015. PMID: 26225912.
- Demehri S, Muhit A, Zbijewski W, Stayman JW, Yorkston J, Packard N, Senn R, Yang D, Foos D, Thawait GK, Fayad LM, Chhabra A, Carrino JA, Siewerdsen JH. Assessment of image quality in soft tissue and bone visualization tasks for a dedicated extremity cone-beam CT system. Eur Radiol 25(6):1742-51, 2015. e-Pub 2015. PMID: 25599933.
- Lo SF, Otake Y, Puvanesarajah V, Wang AS, Uneri A, De Silva T, Vogt S, Kleinszig G, Elder BD, Goodwin CR, Kosztowski TA, Liauw JA, Groves M, Bydon A, Sciubba DM, Witham TF, Wolinsky JP, Aygun N, Gokaslan ZL, Siewerdsen JH. Automatic localization of target vertebrae in spine surgery: clinical evaluation of the LevelCheck registration algorithm. Spine (Phila Pa 1976) 40(8):E476-83, 2015. PMID: 25646750.
- Uneri A, Stayman JW, De Silva T, Wang AS, Kleinszig G, Vogt S, Khanna AJ, Wolinsky JP, Gokaslan ZL, Siewerdsen JH. Known-Component 3D-2D Registration for Image Guidance and Quality Assurance in Spine Surgery Pedicle Screw Placement. Proc SPIE Int Soc Opt Eng 9415, 2015. PMID: 26028805.
- Gang GJ, Stayman JW, Zbijewski W, Siewerdsen JH. Task-based detectability in CT image reconstruction by filtered backprojection and penalized likelihood estimation. Med Phys 41(8):081902, 2014. PMID: 25086533.
- Wang AS, Stayman JW, Otake Y, Kleinszig G, Vogt S, Gallia GL, Khanna AJ, Siewerdsen JH. Soft-tissue imaging with C-arm cone-beam CT using statistical reconstruction. Phys Med Biol 59(4):1005-26, 2014. e-Pub 2014. PMID: 24504126.
- Stayman JW, Otake Y, Prince JL, Khanna AJ, Siewerdsen JH. Model-based tomographic reconstruction of objects containing known components. IEEE Trans Med Imaging 31(10):1837-48, 2012. e-Pub 2012. PMID: 22614574.
- Lee S, Gallia GL, Reh DD, Schafer S, Uneri A, Mirota DJ, Nithiananthan S, Otake Y, Stayman JW, Zbijewski W, Siewerdsen JH. Intraoperative C-arm cone-beam computed tomography: quantitative analysis of surgical performance in skull base surgery. Laryngoscope 122(9):1925-32, 2012. e-Pub 2012. PMID: 22886622.
- Tward DJ, Siewerdsen JH. Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT. Med Phys 35(12):5510-29, 2008. PMID: 19175110.
- Siewerdsen JH, Moseley DJ, Burch S, Bisland SK, Bogaards A, Wilson BC, Jaffray DA. Volume CT with a flat-panel detector on a mobile, isocentric C-arm: pre-clinical investigation in guidance of minimally invasive surgery. Med Phys 32(1):241-54, 2005. PMID: 15719975.
- Jaffray DA, Siewerdsen JH, Wong JW, Martinez AA. Flat-panel cone-beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys 53(5):1337-49, 2002. PMID: 12128137.
- Siewerdsen JH, Jaffray DA. Cone-beam computed tomography with a flat-panel imager: magnitude and effects of x-ray scatter. Med Phys 28(2):220-31, 2001. PMID: 11243347.
- Siewerdsen JH, Jaffray DA. Optimization of x-ray imaging geometry (with specific application to flat-panel cone-beam computed tomography). Med Phys 27(8):1903-14, 2000. PMID: 10984236.
- Jaffray DA, Siewerdsen JH. Cone-beam computed tomography with a flat-panel imager: initial performance characterization. Med Phys 27(6):1311-23, 2000. PMID: 10902561.
- Siewerdsen JH, Antonuk LE, el-Mohri Y, Yorkston J, Huang W, Cunningham IA. Signal, noise power spectrum, and detective quantum efficiency of indirect-detection flat-panel imagers for diagnostic radiology. Med Phys 25(5):614-28, 1998. PMID: 9608470.
Grant & Contract Support
| Title: | Imaging, Guidance, and QA for Emerging High-Precision Neurosurgical Techniques |
| Funding Source: | NIH/NINDS |
| Role: | Principal Investigator |
| Title: | Quantitative Bone Radiomics using Ultra-High Resolution CT |
| Funding Source: | NIH/NIBIB |
| Role: | Principal Investigator-MDACC |
| Title: | Deformable motion compensation for 3D image-guided interventional radiology |
| Funding Source: | NIH/NIBIB |
| Role: | Co-Investigator |
| Title: | Task-Driven 3D Interventional Imaging |
| Funding Source: | NIH/NIBIB |
| Role: | Co-Investigator |
| Title: | High-Performance 3D Imaging on a Mobile C-Arm |
| Funding Source: | Siemens Healthineers |
| Role: | Principal Investigator |
| Title: | UT STARS |
| Funding Source: | The University of Texas System |
| Role: | Principal Investigator |
| Title: | Image-Guided Robotically Assisted Surgery for Complex Ankle Fracture Dislocations |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | 3D Imaging and Registration for Bronchoscopic Procedures (MDA-2022-ATSU-Siewerdsen-Technical) |
| Funding Source: | Siemens Healthineers |
| Role: | Principal Investigator |