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Jesse Joshua Smith

Department of Colon & Rectal Surgery, Division of Surgery

Present Title & Affiliation

Primary Appointment

Professor, Department of Colon and Rectal Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Chair, Department of Colon and Rectal Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas

Dual/Joint/Adjunct Appointment

Professor, Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX

Dual Appointment, Department of Surgery, Weill Cornell, Department of Surgery, Weill Cornell Medical College, New York, NY

Research Interests

The SmithLab developed the first patient-derived rectal cancer organoids (PDOs). These RC PDOs recapitulate the clinical and molecular features of patients with RC and uniquely reflect the clinical responses to therapy of the patients from which they were derived. I obtained an R37 to further develop and expand this RC model, and my work as a clinician and clinical trialist completely overlaps with my basic and translational work focused on improving response to neoadjuvant therapies for patients with RC by developing better disease models. I have demonstrated the ability to develop strong collaborative relationships as evidenced by ongoing work with Drs. Romesser, Paty, Garcia-Aguilar and through this unique collaborative initiative we have been able to identify and characterize novel radiosensitizers to take forward into Phase I clinical trials with parallel co-clinical trials in RC PDOs.

Further, we have improved our initial in vivo endoluminal RC model by translating it to the immunocompetent setting to better understand the biology contributing to chemoresistance and radioresistance in RC (PMID 36590695). I am actively working to extend and validate findings from the OPRA trial (PMID:35483010) and our ongoing work in this space (PMIDs: 39808079; 39266364; 39060961) to better identify complete responders to neoadjuvant therapy with the end goal of increasing the number of patients who can benefit from organ preservation. Our RC tumoroid model fills an unmet need by enabling the discovery of robust, cost-effective molecular biomarkers for RC patients. This has led to ongoing R37 funding through 2027 (extension approved). Furthermore, recent work has led to a provisional patent filing as well as a new SBIR grant with Orbits Oncology recently submitted (January 2025). In addition, we are exploring the utility of radiosensitizers to better target tumor downsizing using our models in addition to using normal tissues in a novel manner to expand the therapeutic index and spare normal tissues: https://www.medrxiv.org/content/10.1101/2025.01.15.25320629v1

To translate our pre-clinical results, there is a critical need to develop reproducible, robust, and clinically useful biomarker panels for identifying RC patients most likely to benefit from neoadjuvant therapies. Furthermore, it is imperative to discover new biomarkers for targeted treatments in patients that are resistant to total neoadjuvant therapy (TNT) as some modern trials have shown patients with excellent response whilst others lag behind. We are uniquely positioned to address these needs and identify reliable biomarkers as we can derive patient-specific models pre-treatment and at separate points during treatment to identify the key features of resistant tumors so that we can target these features and then render tumors sensitive. Since tumoroids consist of tumor epithelial cells and we showed that our RC tumoroid model corresponds to TNT of RC patients, the premise of our recently submitted multi-PI RO1 application with long-time collaborator Dr. Xi Chen is that we can maximize the utility of our model to derive effective intrinsic molecular biomarkers for TNT response by strategically combining genomic data from tumoroids and matched primary tumors of RC patients (https://www.medrxiv.org/content/10.1101/2024.01.29.24301906v1).

Lastly, as an active clinical trialist and Chair of the National Phase II now Phase III trial (The Janus Rectal Cancer Trial – opened 9 November 2022 – NCT05610163 (n=776/760 patients (now completed as of 2 July 2025)) that was built on the findings from the OPRA trial, I am well positioned to ask and answer relevant translational and clinical research questions to improve outcomes for RC patients. MSK served as the lead site for the trial and accrued ~66 patients to the trial – notably MD Anderson accrued the last patient on the trial in collaboration with our partners at Ben Taub. Notably, this trial rapidly accrued nationwide and is 100% accrued for the Phase II and the Phase III portion employing disease-free survival as the endpoint. The Janus Rectal Cancer Trial is the largest clinical trial in the world for RC patients, and we are well-positioned to perform and continue parallel co-clinical trial work at both MSK and MDACC.

Education & Training

Degree-Granting Education

2010	Vanderbilt University, Nashville, Tn, US, Ph.D
2004	The University of Texas Medical School, Houston, Tx, US, M.D
1997	Baylor University, Waco, TX, US, B.S.Ed

Postgraduate Training

2013-2015	Complex Surgical Oncology, Rectal and Colon Cancer Special Emphasis (year 2), Memorial Sloan Kettering, New York, NY
2006-2010	Postgraduate Fellow, Rectal and Colon Cancer Special Emphasis (year 2), Vanderbilt University, Nashville, Tx
2004-2013	Clinical Residency, Rectal and Colon Cancer Special Emphasis (year 2), Vanderbilt University Medical Center, Nashville, Tn

Licenses & Certifications

2025	Texas Medical License
2014	American Board of Surgery
2013	New York Medical License
null	New Jersey Medical License

Experience & Service

Administrative Appointments/Responsibilities

*MSK Surgical Oncology Training Grant – Contact PI/PD with Dr. Mehrara, Project Leader, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 2025 - Present

Research Platform PAC Representative, Department of Surgery, Digits Advisory Committee, Memorial Sloan Kettering Cancer Center,, New York, NY, 2022 - 2025

Member of the Finance Committee and active in measures to improve the financial health of the Department of Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center,, New York, NY, 2019 - 2025

Co-lead Precision Modeling Initiative, Memorial Sloan Kettering Cancer Center, New York, NY, 2018 - 2025

Director of the Basic & Translational Science Curriculum, Department of Surgery, Memorial Sloan Kettering Cancer Center, laboratory manager, Assistant lab manager and Chief administrative research fellows and coordinates Departmental educational activities, New York, NY, 2017 - Present

Chief Administrative Fellow, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 2014 - 2015

Other Professional Positions

Co-founder, fitness consulting business, Biokinetics, Inc, Boca Raton, FL, 1998 - 2000

Certified Strength & Conditioning Specialist, Cooper Aerobics Enterprises; The Cooper Fitness Center, Dallas, TX, 1997 - 2000

Personal Trainer, The Houstonian Club, Houston, TX, 1997 - 1997

Strength and Conditioning Student Coach (Multiple sports), Baylor University, Waco, TX, 1995 - 1997

Institutional Committee Activities

Chair, ASCRS Rectal Cancer Committee, 2025 - Present

Vice Chair, ASCRS Rectal Cancer Committee, 2024 - 2025

Trustee, ASCRS Research Foundation Board of Trustees, 2024 - 2027

Co-Chair with Rebecca Snyder, MD, GI Surgery Working Group, 2023 - Present

Organizer/Basic Sciences Moderator, Basic Sciences Session | Annual Meeting, 2021

Chair, Research Foundation, 2021 - 2023

Co-Chair with Hanna Sanoff, MD, GI Oncology Portfolio, 2021 - Present

Organizer/Basic Sciences Moderator, Fall Course Faculty, 2020

Member, Board of Visitors, 2020 - Present

Vice Chair, Research Foundation, 2019 - 2021

Honors & Awards

2022 - Present	Elected to Surgical Biology Club, Honorary Surgical Society
2022 - 2023	Weill Cornell Medicine Resident Teaching Award 2023 – 4th Year General Surgery Residents, Weill Cornell Medicine General Surgery Teaching Award
2020 - Present	R37 NCI MERIT Award for Early-Stage Investigators, National Cancer Institute
2019 - Present	Elected Core MSKCC Surgical Oncology Fellowship Faculty Member, Memorial Sloan Kettering Cancer Center Department of Surgery
2017 - 2019	27th Franklin Martin, MD, FACS Faculty Research Fellowship, American College of Surgeons
2016 - Present	2016 Joel J. Roslyn Faculty Research Award, Association of Academic Surgery
2015 - Present	Michael E. Burt, M.D., Ph.D. Award for Clinical Excellence, Memorial Sloan Kettering Cancer Center Department of Surgery
2015 - Present	Conquer Cancer Foundation of the American Society of Clinical Oncology (ASCO) Merit Award—Gastrointestinal Symposium 2015, American Society of Clinical Oncology
2014 - 2015	Chief Administrative Fellow (new programs added) -Instituted night-time surgical-only PA coverage to enhance continuity of care and reduce exposure to work hour requirements. -Established the Quality Fellow and the ACGME fellow. -Established the Fellows’ Council. Established a shared leadership role with the schedule, social events, conference planning and interaction with Drs. DeMatteo, D’Angelica and Ariyan, Memorial Sloan Kettering Cancer Center Department of Surgery
2013 - Present	The Harwell Wilson Award for Surgical Excellence - recognizes the resident judged as outstanding in dedication to patient care, research & teaching, Vanderbilt University Department of Surgery
2013 - Present	Elected to Alpha Omega Alpha Honor Medical Society, Vanderbilt University School of Medicine
2013 - Present	The Joseph W. and Bonnie J. Graves Award in Surgery - for outstanding commitment, interest & effectiveness in teaching, Vanderbilt University Department of Surgery
2012 - Present	Alfred Blalock Surgical Resident Award (most outstanding Research Contributions), Vanderbilt University Department of Surgery
2011 - Present	ACS Tennessee Chapter Annual Meeting Cancer Paper Competition Winner, American College of Surgeons – Tennessee Chapter
2010 - Present	Society of University Surgeons, Ethicon Fellowship Award, Society of University Surgeons
2010 - Present	Graduate Student of the Year, Ingram-Cancer Center Retreat, Vanderbilt University
2010 - Present	Stanley J. Korsmeyer Young Investigator Award, American Society of Clinical Investigation (ASCI), American Society of Clinical Investigation
2008 - Present	ACS Tennessee Chapter Annual Meeting Cancer Paper Competition Winner, American College of Surgeons – Tennessee Chapter
2007	93rd Annual Clinical Congress Excellence in Research Award, American College of Surgeons
2004	Walter G. Sterling, Most Outstanding Medical Student Award, The University of Texas Medical School at Houston

Professional Memberships

American Society of Colon and Rectal Surgeons, Rectal Cancer Committee

2024 - Present

Society of Surgical Oncology

2024 - 2025

Alliance for Clinical Trials in Oncology | GI Surgery Working Group

2023 - Present

American Society of Colon and Rectal Surgeons, Research Committee

2021 - 2023

Alliance for Clinical Trials in Oncology | GI Oncology Portfolio

2021 - Present

Rectal Cancer Committee -American Society of Colon and Rectal Surgeons

2020 - 2023

Society of Surgical Oncology Representative | ACS Synoptic Operative Report Work Group for Colon Cancer

2020 - Present

American Society of Colon and Rectal Surgeons, Rectal Cancer Committee

2020 - 2023

Association of Academic Surgery Leadership Committee

2019 - 2021

National Accreditation Program for Rectal Cancer Accreditation

2019 - 2021

American Society of Colon and Rectal Surgeons, Research Committee,

2019 - 2021

Association of Academic Surgeons Representative on the American College of Surgeons Surgical Research Committee

2019 - Present

National Cancer Treatment Network, Alliance for Clinical Trials in Oncology

2017 - Present

National Cancer Institute, Rectal Anal Task Force

2017 - Present

Basic and Translational Science Committee for the Association for Academic Surgery (AAS)

2016 - 2018

American Society of Colon and Rectal Surgeons Program and Awards Committee

2016 - 2022

OSTRiCH (Optimizing the Surgical Treatment of Rectal Cancer) Committee - Now known as the National Accreditation Program for Rectal Cancer (NAPRC)

2016 - Present

Association of Academic Surgery Basic and Translational Science Committee

2016 - 2018

Disease Site Working Group, Society of Surgical Oncology

2016 - 2023

The Society for Surgery of the Alimentary Tract

2016 - Present

Colorectal Disease Site Working Group, Society of Surgical Oncology

2016 - Present

Society of American Gastrointestinal and Endoscopic Surgeons

2015 - Present

Association for Academic Surgery

2014 - Present

American Society of Colon and Rectal Surgeons

2013 - Present

Society of Surgical Oncology

2013 - Present

American Society of Clinical Oncology

2010 - Present

American Association of Cancer Research

2008 - Present

American College of Surgeons

2004 - Present

American Medical Student Association

2004 - Present

Selected Presentations & Talks

Regional Presentations

2024. Emerging Treatment Paradigms in Rectal Cancer: Optimizing Response, Paradigm Shifts & Nonoperative Management in Rectal Cancer. Invited. Mt. Sinai/Elmhurst Hospital Center Cancer Symposium. New York, NY, US.
2023. Precision Therapy in Rectal Cancer: Myth or Reality?. Invited. Department of Surgery Grand Rounds. New York, NY, US.
2023. Precision Therapy in Rectal Cancer 2023: How Funding Helps Source Discovery. Invited. New York, NY, US.
2021. Memorial Sloan Kettering Global Cancer Disparities Initiatives. Invited. MSK Global Cancer Disparity Initiative | on behalf of T. Peter Kingham, MD. New York, NY, US.
2020. Organoid Models in Cancer. Invited. Hospital Research Forum, Inaugural Lecture with Charles L. Sawyers, MD. New York, NY, US.
2018. Updates on Rectal Preservation and Precision Modeling in Rectal Cancer. Invited. Department of Surgery Grand Rounds. New York, NY, US.
2018. Memorial Sloan Kettering Global Cancer Disparities Initiatives. Invited. Pink for Africa Hats, Ties & Conversation Program, Fundraising event. New York, NY, US.
2015. SMAD4, the surgeon and the mystery of predicting individual outcomes in colorectal cancer patients. Invited. Surgical Grand Rounds. Waterbury, CT, US.
2013. Smad4, the surgeon and individualized cancer therapeutics in colorectal cancer (CRC) patients. Invited. Surgical Grand Rounds. Nashville, TN, US.

National Presentations

2024. Updates on the Janus Rectal Cancer Trial. Invited. The Alliance for Oncology, Oncology Nursing Committee Fall Meeting | Oncology Nursing Session, US.
2024. Precision Therapy in Rectal Cancer: Hope or Hype?. Invited. 2024 Surgical Section Meeting, US.
2024. Surveillance in Non-metastatic Rectal Cancer. Invited. Colontown DocTalks Session with Ben Schlechter, US.
2023. How to Optimize Your Research Team. Invited. NCI Early Surgeon Scientist Program (ESSP) II 2023 Fall Symposium | Smith JJ and Pai Sara, US.
2023. Total Neoadjuvant Therapy and Watch and Wait in 2023: A Shifting Paradigm. Invited. 2023 Idaho Society of Clinical Oncology Annual Meeting, US.
2023. Optimizing Response, Preserving the Organ & A Paradigm Shift in Rectal Cancer Welcome to Rectal Cancer in 2023. Invited. 2023 CGA-IGC Annual Meeting, US.
2023. Precision Therapy in Rectal Cancer: Myth or Reality?. Invited. Research Symposium honoring R.Daniel Beauchamp, M.D. Nashville, TN, US.
2023. Precision Therapy in Rectal Cancer: Myth or Reality?. Invited. Visiting Professor, Department of Surgery, Division of Surgical Oncology Professor. Dallas, TX, US.
2023. Colontown Post-ASCO Colorectal Session. Invited. Colontown Virtual Post-ASCO Session with Drs. Eng, Krishnamurthi and Sanford – hosted by Dr. M. George, US.
2023. Watch and Wait: When and How to Intervene. Invited. American Society of Colon and Rectal Surgeons Annual Scientific Meeting | Rectal Cancer Super Session, Current Controversies in Rectal Cancer Management, US.
2023. Top 5 Clinical Trials: Latest and Greatest, The Next Big Thing. Invited. American Society of Colorectal Surgeons Annual Scientific Meeting 2023 | Co-Moderator and Lead. Seattle, WA, US.
2023. Optimizing Response, Preserving the Organ & A Paradigm Shift | Welcome to Rectal Cancer in 2023. Invited. The Alliance for Oncology, Oncology Nursing Committee Spring Meeting | Oncology Nursing Session, US.
2023. Improving cancer care for patients in Nigeria: The Ile Ife Story (on behalf of Drs. Kingham and Alatise). Invited. 50th Anniversary H. William Scott Society Meeting. Nashville, TN, US.
2023. Rectal Cancer Updates in 2023. Invited. Total Health Conferencing. Nashville, TN, US.
2022. Treatment Escalation: Chemotherapy, Radiation & Radiation Sensitizers. Invited. 6th Annual Advances in Colorectal Oncology: Improving Practice Through New Discoveries, US.
2022. Nonoperative Management in Rectal Cancer: Worth the Wait or Waste of Time?. Invited. University of Florida Health Cancer Center Oncology Grand Rounds. Gainesville, FL, US.
2022. American College of Surgeons Clinical Congress 2022. Invited. Minimal residual disease paradigm and ctDNA use for stages 1-3 colorectal cancer. San Diego, CA, US.
2022. AllyCon Annual Meeting. Invited. Results Heard Around the World; 100% Response Rate. Philadelphia, PA, US.
2022. American Society of Clinical Oncology - Discussion of Abstracts 3515-3517. Invited. Gastrointestinal Cancer-Colorectal and Anal Poster Discussion Section – Poster Discussant, US.
2022. Precision Therapy in Rectal Cancer: Myth or Reality?. Invited. Surgical Research Symposium | Keynote Speaker. Little Rock, AK, US.
2022. A Rectal & Colon Cancer Surgeon-Scientist: Indeed Possible From Nothing to Something. Invited. Surgeon-Scientist Parallel Session | L. Maguire and J. Mitchem Chairs. Tampa, FL, US.
2022. Unique Aspects of Rectal Cancer Management in Hereditary Colorectal Cancer Syndromes. Invited. Decoding the Care of Genetic Cancers M. Kalady and W. Harb Chairs. Tampa, FL, US.
2022. Long-term Surveillance and Timing of Surgery for Regrowth. Invited. Nuts and Bolts of Watch and Wait/Nonoperative Management in Rectal Cancer, US.
2021. Nonoperative Management of Rectal Cancer: Is It Time for Watch & Wait or Just More Wait & See?. Invited. Colontown DocTalks, US.
2021. Advances in the Treatment of Rectal Cancer. Invited. SSO Virtual Fellows Retreat 2021, US.
2021. A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation. Invited. AACR Virtual Special Conference on Colorectal Cancer, US.
2021. The Nonoperative Management of Rectal Cancer at MSKCC. Invited, US.
2021. Colorectal Virtual Tumor Board: Multidisciplinary Management of Locally Advanced Colon Cancer. Invited. Society of Surgical Oncology Virtual Tumor Board Series, US.
2021. Watch & Wait or More Wait & See with TNT?. Invited. Yale Center for GI Cancers, US.
2021. Expanding a rectal cancer organoid platform to study individual responses to chemoradiation. Invited. Presented at the Oncology Models Forum Annual Meeting at the National Cancer Institute (by invitation), US.
2020. Development of an accurate model for more precise treatment of the rectal cancer patient. Invited. Innovations in GI Cancer | 11th Annual Ruesch Symposium, US.
2020. Seeds Grants and Start Up Funds. Invited. Association of Academic Surgeons, Virtual Early Career Development Course, US.
2020. Total Neoadjuvant Therapy in Rectal Cancer & Organ Preservation. Invited. Society of Surgical Oncologists Live Program 2020 | via GoTo Meeting Clinical Trials in Colorectal Cancer Series, US.
2020. The preliminary results of the organ preservation in rectal adenocarcinoma trial (OPRA). Invited. Presented at the American Society of Clinical Oncology Meeting, US.
2019. High tumor mutation burden correlates with complete response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. Invited. ePoster presentation at the the American Society of Colon & Rectal Surgeons Annual Meeting, US.
2019. Surgical Considerations (and Embedded Quality of Life Issues) for Young Onset Rectal and Colon Cancer Patients. Invited. Society of Surgical Oncology Young Onset CRC Symposium at the Annual Meeting, US.
2019. KRAS Mutation is Associated with Immunosuppressive Tumor Microenvironment in MismatchRepair Proficient Colorectal Cancer. Invited. Podium presentation at the Society of Surgical Oncology (SSO) Annual Meeting, US.
2019. KRAS mutation is associated with upregulation of Integrin beta-4 expression leading to tumor invasion in colorectal cancer. Invited. Poster presentation at the Gastrointestinal Cancers Symposium (ASCO-GI), US.
2018. Research Symposium Honoring R. Daniel Beauchamp, M.D. Precision Modeling Using Rectal Cancer Tumoroids. Invited. Research Symposium: Basic & Translational Research by Surgeons. Nashville, TN, US.
2018. Utilization of a Smad4-modulated gene expression profile to identify small molecules/compounds that recapitulate the tumor suppressor effects of SMAD4 and predict resistance to therapy in colorectal cancer patients. Invited. 13th Annual Academic Surgical Congress, Jacksonville, FL AAS/ASC Research Awards Presentation 2018 Presentation for the 2016 Joel J. Roslyn, MD Faculty Research Fellowship Award. Jacksonville, FL, US.
2018. Basic Science Committee Session: ‘So You Want to be a Surgeon-Scientist – How to Succeed in Today’s Environment’. Invited. 13th Annual Academic Surgical Congress, Jacksonville, FL Mock Interview Session with Melina Kibbe. Jacksonville, FL, US.
2018. SMAD4 loss in patient-derived colorectal cancer tumoroids confirms chemoresistance. Invited. Oral Presentation 2018 Annual Academic Surgical Congress, US.
2017. The ACS/CoC National Accreditation Program for Rectal Cancer: How Does it Work and How to Prepare for the Site Survey Presentation of MDT Cases. Invited. American College of Surgeons Clinical Congress. San Diego, CA, US.
2017. Bridging the gap between end of research years and first faculty appointment. Invited. 2017 Association for Academic Surgery Fundamentals of Surgical Research Course. San Diego, CA, US.
2016. SSAT GI Surgery Debate, Small Bowel & Colorectal: Complete Clinical Response after Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: Watch and Wait or Radical Surgery? (Pro Side). Invited. Presented at 2016 Digestive Disease Week (DDW) / Society for Surgery of the Alimentary Tract (SSAT) Colorectal parallel session, US.
2016. A Smad4-modulated gene profile is associated with high-risk stage II/III colorectal cancer patients. Invited. Oral Presentation 2016 Academic Surgical Congress, US.
2015. SMAD4 loss in the hindgut is associated with worse recurrence-free survival. Invited. Presented at the Press Program for the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Chicago, IL, US.
2015. Watch & Wait after CRT: Is it ready for prime time. Invited. Emerging Trends in the Workup and Management of Rectal Cancer American College of Surgeons Annual Clinical Congress 2015. Chicago, IL, US.
2015. Organ preservation in rectal cancer patients with clinical complete response after neoadjuvant therapy. Invited. Oral Presentation 2015 SSO Annual Symposium, Colorectal Session, US.
2015. Organ preservation in patients with rectal cancer with clinical complete response after neoadjuvant therapy. Invited. Conquer Cancer Foundation, American Society of Clinical Oncology, Merit Award Winner, 2015 Gastrointestinal Symposium, US.
2014. Integrating Multiple Layers of Genomic Data to Identify Regulatory Programs of Gene Expression in KRAS Mutant Rectal Cancers. Invited. American College of Surgeons 100th Annual Clinical Congress, US.
2014. Single nucleotide polymorphisms in XRCC1, XPD and TGF-beta predict the risk of proctitis in patients receiving radiation therapy for rectal cancer. Selected as an oral presentation. Invited. Society of Surgical Oncology Annual Cancer Symposium, Colorectal Parallel Session, US.
2012. Cancer After Thyroidectomy: A Multi-Institutional Experience With 1,523 Patients. Invited. Southern Surgical Annual Meeting, The Breakers. Palm Beach, FL, US.
2012. A Smad4-modulated Wnt Target gene expression profile identifies high-risk colorectal cancer patients. Invited. Presented at the Surgical Forum at the American College of Surgeons Annual Clinical Congress, US.
2012. Toxic nodular goiter and cancer: A compelling case for thyroidectomy. Invited. Annual Meeting of the American Association of Endocrine Surgeons, US.
2012. Smad4 loss activates Wnt signaling, beta-catenin gene (ctnnb1) transcription and promotes intestinal neoplasia. Invited. Fourth Annual Collaborative Research Forum Meeting. Sanibel Island, FL, US.
2011. Does Intentional Support of Degree Programs in General Surgery Residency Affect Productivity of Residents and Production of Academic Surgeons?. Invited. Oral presentation at the Associate of Program Directors in Surgery, Annual Meeting, US.
2011. Biological Models of Colorectal Cancer Metastasis and Tumor Suppression Provide Mechanistic Insights to Guide Personalized Care of the Colorectal Cancer Patient. Invited. Final Presentation to the Executive Board and the Society of University Surgeons, US.
2011. Biological Models of Colorectal Cancer Metastasis Provide Mechanistic Insights to Guide Personalized Care of the Colorectal Cancer Patient and Pursuit of a Career as a Physician Scientist at Vanderbilt. Invited. First Annual, Physician Scientist Second-Look Weekend, US.
2009. An Experimentally-Derived Metastasis Gene Expression Profile Predicts Cancer-Related Recurrence and Death in Patients with Colon Cancer. Invited. National Cancer Institute Translational Science Meeting. Vienna, VA, US.
2009. An Experimentally-Derived Metastasis Gene Expression Profile Predicts Cancer-Related Recurrence and Death in Patients with Colon Cancer. Invited. Medical Scientist Training Program, US.
2009. An Experimentally-Derived Metastasis Gene Expression Profile Predicts Cancer-Related Recurrence and Death in Patients with Colon Cancer. Invited. 2009 Tennessee Chapter, American College of Surgeons Cancer Paper Competition; Awarded best paper. Fall Creek Falls State Park, TN, US.
2009. An Experimentally-Derived Metastasis Gene Expression Profile Predicts Cancer-Related Recurrence and Death in Patients with Colon Cancer. Invited. National Predoctoral Clinical Research Training Program Meeting. St. Louis, MO, US.
2008. Identification of a Genetic Program for Tumor Suppression Lost in Smad4 Deficient Colorectal Carcinomas. Invited. 94th Annual Clinical Congress of the American College of Surgeons; highest scoring presentation for category. San Francisco, CA, US.
2008. Microarray Analysis of Smad4 Gene Expression and Impact on Survival in Human Colorectal Cancer. Invited. Society of University of Surgeons 3rd Annual Academic Surgical Congress. Huntington Beach, CA, US.

International Presentations

2025. Novel neoadjuvant treatments to enhance cCR in rectal cancer. Invited. SOLAR Trial Symposium. DongDaegu, KR.
2025. Targeted TNT for rectal cancer; to improve survival, NOM or both?. Invited. SOLAR Trial Symposium. DongDaegu, KR.
2025. Update on the Landscape of Rectal Cancer Trials. Invited. SWOG Spring Meeting, US.
2025. The Critical Role of the Surgeon and Surgeon-Scientist in the Management and Treatment of the Rectal Cancer Patient in 2025. Invited. AACR Annual Meeting | Special Session The Role of Surgery in Modern Cancer Treatment: Opportunity for Patient-derived Models or Art of Diminishing Return Smith talk: Optimizing Response & Rectal Preservation in the Modern Era of Rectal Cancer Treatment| Leading the Way with Patient-derived Models, US.
2025. The Importance of Mismatch Repair in Colorectal Cancer. Invited. The Society of Surgical Oncology | Annual Meeting | Uncommon Colorectal Malignancies & Challenging Clinical Situations, US.
2025. Precision Therapy in Rectal Cancer 2025: Models, Trials & Targets. Invited. Seoul International Symposium of Surgical Oncology, US.
2025. Optimizing Response, Preserving the Organ & Paradigm Shifts in Rectal Cancer: Welcome to Rectal Cancer in 2025. Invited. Seoul International Symposium of Surgical Oncology, US.
2024. Expansion and Investigation of Tumoroid Models for More Precise Treatment of Rectal Cancer Patients: Past, Present & Future. Invited. 2024 Oncology Models Forum Series Webinar, US.
2024. The Janus Rectal Cancer Trial and Updates. Increasing complete response – more chemotherapy?. Invited. FICARE 2024, US.
2024. How to increase complete response: more chemotherapy?. Invited. 8th Annual Advances in Colorectal Oncology | MSKCC CME Event, US.
2024. The Importance of Mismatch Repair in Colorectal Cancer. Invited. American College of Surgeons Annual Meeting | Hot Topics in Surgical Oncology, US.
2024. Overview of Genetic and Molecular Testing. Invited. American College of Surgeons Annual Meeting |, US.
2024. Precision Therapy in Rectal Cancer 2024: Models, Trials & Targets. Invited. Surgical Biology Club (SBC) | pre-ACS Annual Meeting, Annual SBC Scientific Session, US.
2024. Recent Updates in Locally Advanced Rectal Cancer. Invited. Faculty Invitation | PER’s ISGIO Conference, US.
2024. Considerations for Low-Mid Rectal Cancer in 2024: Implications for the Surgeon. Invited. Annual African Research Group for Oncology Conference via Zoom, US.
2024. Precision Rectal Cancer Treatment in 2024: Hope or Hype?. Invited. Department of Surgery Grand Rounds, US.
2024. Enhancing Data Reuse in Cancer Research. Invited. NCI Workshop via Webex | Moderator for Session 1 | Clinical and Epidemiological Data Usage, US.
2024. When you need to take more in locally advanced and metastatic CRC – and when to stop. Invited. It’s a Team Sport, Partnering with Other Specialties, US.
2024. Watch and Wait in 2024. Invited. Meet the Professor Session with R. Perez, MD, US.
2024. Short-Course vs. Long-course radiotherapy in locally advanced rectal cancer: SHORT COURSE. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2024. Special Invitation as International Guest - Thesis Defense Committee Member | Floris Verheij. Invited. Thesis Defense Committee. Maastricht, NL.
2024. Operating in the Radiated Pelvis: Pitfalls and Solutions. Invited. Moderator | Annual Society of Surgical Oncology Annual Meeting. Atlanta, US.
2023. Precision in Rectal Cancer Treatment in 2023: Hope or Hype?. Invited. CBATS Speaker University of Michigan, US.
2023. Expansion of Tumoroid Models for More Precise Treatment of Rectal Cancer Patients: Past, Present & Future. Invited. 2023 Oncology Models Forum Annual Meeting, US.
2023. Optimizing Neoadjuvant Strategies for WW. Invited. 7th Annual Advances in Colorectal Oncology | MSKCC CME Event, US.
2023. Getting to a clinical complete response. Invited. American College of Surgeons Clinical Congress | Do We Still Need to Wait on Watch and Wait? Contemporary Management of Rectal Cancer, US.
2023. Optimizing management of colon and rectal cancer. Invited. 2023 ARGO Symposium Program, US.
2023. Clinician/Reader Training for GSK Dostarlimab International Trial. Invited. Workshop for Radiologists and Endoscopists on detecting Clinical Complete Response, US.
2023. Induction vs. Consolidation Approach: Low versus Mid-Rectal Cancer. Invited. Oncological Strategy Session, US.
2023. Surveillance and Treatment of Anal Dysplasia. Invited. Annual Meeting of the Society of Surgical Oncology | HUB Session | Moderator and Lead, US.
2023. Total Mesorectal Excision: Pro-Robotic Approach. Invited. Controversies in Colorectal Oncology | International Symposium 2023. Santiago, CL.
2023. Toward Prediction of Response in Locally Advanced Rectal Cancer: Progress and Modern Approaches. Invited. Controversies in Colorectal Oncology | International Symposium 2023. Santiago, CL.
2023. Surgery and Precision Therapy in Rectal Cancer. Invited. Surgery Service, Sotero Del Rio. Santiago, CL.
2023. FDA ODAC Panel Presentation for GSK. Invited. Scientific Rationale Supporting cCR as an Endpoint in Clinical Trials, US.
2022. The Nonoperative Management of Rectal Cancer. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. Can we change from an APR to an intersphincteric resection? NO!. Invited. FICARE2022. Sao Paolo, BR.
2022. Near complete response in the context of a watch-and-wait strategy – my view. Invited. FICARE2022. Sao Paolo, BR.
2022. Should Nonoperative management be standard of care?. Invited. The Greater Ireland Colorectal Cancer Conference. Dublin, IE.
2022. Perspectives on TNT, OPRA and beyond. Invited. The Greater Ireland Colorectal Cancer Conference. Dublin, IE.
2022. Perspectives on the Modern Treatment of Colon and Rectal Cancer in 2022. Invited. African Research Group for Oncology Symposium 2022 via Zoom (Virtual Conference by Invitation). Ile Ife, NG.
2022. The Nonoperative Management of Rectal Cancer. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. Short-Course vs. Long-course radiotherapy in locally advanced rectal cancer: LONG COURSE. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. Non-operative management in rectal cancer: worth the time or waste of time?. Invited. 2022 Surgery Forum: Innovation & Creativity. Tainan, TW.
2022. Precision Therapy in Rectal Cancer & New Horizons in Immunotherapy | Session on Neoadjuvant immunotherapy in colorectal cancer (via Zoom). Invited. Center for Surgical Sciences. Koge, DK.
2022. The Nonoperative Management of Rectal Cancer. Invited. MASTER XPERIENCE COL 2022 program. Cartagena, CO.
2022. The Nonoperative Management of Rectal Cancer. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. Short-Course vs. Long-course radiotherapy in locally advanced rectal cancer: SHORT COURSE. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. Short-Course vs. Long-course radiotherapy in locally advanced rectal cancer: SHORT COURSE. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2022. The Nonoperative Management of Rectal Cancer. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2021. Expanding a rectal cancer organoid platform to study individual responses to chemoradiation. Invited. AACR Virtual Special Conference on Colorectal Cancer, US.
2021. The Nonoperative Management of Rectal Cancer. Invited. Great Debates & Updates in Gastrointestinal Malignancies, US.
2021. Predictors of Pathologic Complete Response in Rectal Cancer. Invited. 1st International Symposium | Controversies in Colorectal Oncology In association with the Clinica Universidad de Los Andes. Santiago, CL.
2021. Advances in the Treatment of Locally Advanced Rectal Cancer. Invited. African Research Group for Oncology Symposium 2021, Ile Ife, Nigeria via Zoom (Virtual Conference due to COVID-19), NG.
2020. Modern Approaches to Organ Preservation in Rectal Cancer. Invited. Japanese Surgical Society 2020 | via Zoom |, JP.
2019. A Rectal Cancer Model for Determine Response to Chemoradiation. Invited. FICARE 2019. Sao Paulo, BR.
2019. Metastatic Rectal Cancer: What to do with the primary tumor in 2019?. Invited. FICARE 2019. Sao Paulo, BR.
2019. AORTIC Annual Conference Session on Clinical Trials. Invited. AORTIC Annual Conference. Maputo, MZ.
2019. Early Rectal Cancer | What Are We to Do?. Invited. Toronto, CA.
2019. Metastatic Rectal Cancer: What to do with the primary tumor in 2019?. Invited. Toronto, CA.
2019. Clinical Complete Response: What is It and Why Does It Matter? And How Do I Follow My Patients?. Invited. Toronto, CA.
2019. Watch & Wait in the Multidisciplinary Management of Patients with Locally Advanced Rectal Cancer. Invited. Chinese Society of Clinical Oncology (CSCO) Annual Meeting Society of Surgical Oncology and CSCO Joint Symposium, US.
2019. Epidemiology, Burden & Molecular Biology of Colorectal Cancer in Sub-saharan Africa. Invited. African Research Group for Oncology Master Class 2019. Ile Ife, NG.
2018. Watch and Wait: The Impact of Total Neoadjuvant Therapy Organ preservation for clinical T2N0 distal rectal cancer. Invited. 6th Nordic Early Rectal Cancer Meeting. Bergen, NO.
2017. 1) Total mesocolic excision vs. conventional colectomy for right-sided colon cancer. Colon cancer: open, laparoscopic or robotic surgery? 2) Clinical complete response - so now what? Watch & Wait, local excision or TME?. Invited. 66th Brazilian Coloproctology Congress in Foz do. Iguaçu, BR.
2017. Organ Preservation in Rectal Adenocarcinoma Local Recurrence in Rectal Cancer Pelvic Exenterations: Resection Techniques. Invited. Presented at 2017 RNAEC Conference. Almería, ES.
2017. Current Trends in the Management of Colon and Rectal Cancer Developing an ERAS Protocol in Nigeria and Nursing Collaboration Grant Opportunities (and Strategy) in Oncology Research. Invited. 017 African Research Group for Oncology (ARGO) National Cancer Institute Approved Colorectal Cancer Consortium. Ile-Ife, NG.
2015. Enhanced Recovery Strategies in CRC. Invited. ARGO 2015, CRC Master Class. Ile Ife, NG.
2015. Local therapy in rectal cancer. Invited. ARGO 2015, CRC Master Class. Ile Ife, NG.
2015. Screening and detection of CRC. Invited. ARGO 2015, CRC Master Class. Ile Ife, NG.

Less

Grant & Contract Support

Date:	2026 - 2032
Title:	Network Lead Academic Participating Site: Memorial Sloan Kettering Cancer Center
Funding Source:	Network Lead Academic Participating Site: Memorial Sloan Kettering Cancer Center
Role:	PI

Date:	2025 - 2026
Title:	Development of a Predictive Model for Rectal Cancer Clinical Outcomes Using Patient-Derived Organoids
Funding Source:	SBIR
Role:	PI
ID:	WS01454532-PA-24-245

Date:	2025 - 2027
Title:	Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient
Funding Source:	National Cancer Institute
Role:	PI
ID:	Parent GRANT 12873049 \| R37 Research Extension to the parent grant R37 CA248289

Date:	2025 - 2030
Title:	Tumoroid-based computational models for rectal cancer biomarker discovery
Funding Source:	National Cancer Institute
Role:	PI
ID:	C01 – Univ. of Miami MPI R01

Date:	2024 - 2027
Title:	Development of a universal mRNA vaccine targeting APC mutations for colorectal cancer prevention
Funding Source:	Congressionally Directed Medical Research Program
Role:	Co-PI

Date:	2024 - 2029
Title:	T32 Surgical Oncology Research Training Program
Funding Source:	National Cancer Institute (MSK NCI Surgical Oncology T32):
Role:	Co-PI
ID:	T32CA009501-31A1

Date:	2023 - 2026
Title:	To explore the ability of senescence inducing therapies to enhance cell therapy against solid tumors
Funding Source:	The Mark Foundation for Cancer Research
Role:	Co-I

Date:	2023 - 2024
Title:	Diversity Supplement to Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient
Funding Source:	National Cancer Institute
Role:	PI
ID:	Parent GRANT 12873049 \| R37 Research Supplement to Promote Diversity in Health-Related Research under the parent grant R37 CA248289

Date:	2021 - 2022
Title:	Leveraging Radiation Induced Senescence (RIS) to Potentiate Anti-Tumor Immunity
Funding Source:	Geoffrey Beene Cancer Center
Role:	Co-PI

Date:	2020 - 2025
Title:	Expansion of Tumoroid Models for Precise Treatment of the Rectal Cancer Patient
Funding Source:	National Cancer Institute
Role:	PI
ID:	GRANT 12873049 \| R37CA248289

Date:	2019 - 2021
Title:	Translational Platform for the Development, Characterization, and Clinical Assessment of Radiation Sensitizers in Rectal Cancer
Funding Source:	Imaging and Radiation Sciences Program Seed Grant - MSKCC
Role:	Co-I

Date:	2019 - 2021
Title:	Development of an Accurate Model for More Precise Treatment of the Rectal Cancer Patient
Funding Source:	Colorectal Cancer Alliance Chris4Life Rectal Cancer Award
Role:	PI

Date:	2017 - 2020
Title:	Novel Genomic and Immune-Based Strategies for the Treatment of Colorectal Cancer
Funding Source:	Stand Up to Cancer Colorectal Cancer Dream Team Translational
Role:	Co-I

Date:	2017 - 2019
Title:	Rectal Cancer Modeling and Mechanisms of Chemoresistance
Funding Source:	Research Foundation of the American Society of Colon and Rectal Surgeons – Career Development Award
Role:	PI

Date:	2017 - 2019
Title:	Defining the role of SMAD4 in Rectal Cancer Using Primary 3D Tumoroid Cultures and a Novel Endoluminal Tumor
Funding Source:	American College of Surgeons Franklin Martin Faculty Research Fellowship
Role:	PI

Date:	2016 - 2020
Title:	Development of an Accurate Model for More Precise Treatment of the Rectal Cancer Patient
Funding Source:	National Institutes of Health, Division of Loan Repayment, Clinical Research LRP
Role:	PI

Date:	2016 - 2017
Title:	Utilization of a Smad4-modulated gene expression profile to identify small molecules/compounds that recapitulate the tumor suppressor effects of Smad4 and predict chemoresistance in colorectal cancer patients
Funding Source:	Joel J. Roslyn Faculty Research Award, Association for Academic Surgery
Role:	PI

Date:	2016 - 2017
Title:	Rectal Cancer Modeling and Mechanisms of Chemoresistance
Funding Source:	Limited Project Grant, American Society of Colon and Rectal Surgeons
Role:	PI

Date:	2016 - 2017
Title:	Defining the Role of SMAD4 in Rectal Cancer using Primary Three-Dimensional (3D) Tumor Cultures and a Novel Endoluminal Tumor Model
Funding Source:	Society Research Grant, The Society of Memorial Sloan Kettering Cancer Center
Role:	PI

Date:	2016 - 2017
Title:	Defining the Role of SMAD4 in Rectal Cancer using Primary Three-Dimensional (3D) Tumor Cultures and a Novel Endoluminal Tumor Model
Funding Source:	Department of Surgery Faculty Research Award, Memorial Sloan Kettering Cancer Center
Role:	PI

Date:	2008 - 2009
Title:	Smad4 exerts tumor suppressor effects via Bone Morphogenetic Protein signaling
Funding Source:	Ethicon-SUS Surgical Research Fellowship Award, The Society of University Surgeons
Role:	PI

Date:	2002 - 2003
Title:	The efficacy of using extensive patient education & functional exercise guidelines in regard to improving quality of life & adherence to lifestyle change postoperatively with thoracoabdominal aortic aneurysm patients
Funding Source:	Carolyn L. Kuckein Student Research Fellowship, Alpha Omega Alpha
Role:	Key

Selected Publications

Peer-Reviewed Articles

Bercz A, Faden DL, Smith JJ, Romesser PB. Clocking Recurrence: Circulating Tumor HPV DNA Kinetics in Anal Cancer. Clin Cancer Res 31(12):2261-2263, 2025. e-Pub 2025. PMID: 40232195.
Neylan CJ, Bercz A, Regenbogen SE, Huang EH, Smith JJ, Maguire LH, Mitchem JB. Appraising a CREATEive Surgeon-Scientist Initiative: Impact and Future Directions. Dis Colon Rectum 68(6):656-657, 2025. e-Pub 2025. PMID: 40035458.
Williams H, Fokas E, Diefenhardt M, Lee C, Verheij FS, Omer DM, Lin ST, Dunne RF, Marcet J, Cataldo P, Polite B, Piso P, Polat B, Dapper H, Ghadimi M, Hofheinz RD, Qin LX, Saltz LB, Wu AJ, Gollub MJ, Smith JJ, Weiser MR, Rodel C, Garcia-Aguilar J. Survival among patients treated with total mesorectal excision or selective watch-and-wait after total neoadjuvant therapy: a pooled analysis of the CAO/ARO/AIO-12 and OPRA randomized phase II trials. Ann Oncol 36(5):543-547, 2025. e-Pub 2025. PMID: 39848335.
Alvarez J, Zambare W, George M, Garcia R, Gallagher P, Kitchens C, Bercz A, Kim MJ, Romesser PB, Cercek A, Garcia-Aguilar J, Sanoff H, George TJ, Hong TS, Yothers G, Philip PA, Al Baghdadi T, Alese OB, Shergill A, O'Reilly EM, Meyerhardt JA, Horvat N, Dasari A, Hall WA, Shi Q, Schrag D, Smith JJ. Utilizing Patient Input in Rectal Cancer Trial Design. J Natl Cancer Inst, 2025. e-Pub 2025. PMID: 40108482.
Roth O'Brien DA, Hristidis VC, Chakrani Z, McCann P, Damato A, Williams V, Cote N, Reyngold M, Rosen R, Connell L, Pappou E, Hajj C, Paty PB, Horvat N, Pernicka JSG, Fiasconaro M, Shia J, Lisanti J, Wu AJ, Gollub MJ, Zhang Z, Yaeger R, Zinovoy M, Weiser MR, Saltz L, Cuaron J, Boe L, Cercek A, Garcia-Aguilar J, Smith JJ, Crane CH, Romesser PB. Clinical Outcomes, Patterns of Failure, and Salvage Therapies of a Large Modern Cohort of Patients With Anal Squamous Cell Carcinoma Treated With Definitive-Intent Intensity-Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 121(4):951-962, 2025. e-Pub 2025. PMID: 39536799.
Smith JJ, Zambare W, Wu C, Huang H, Zhang W, Kim MJ, Alvarez J, Bercz A, Paty PB, Romesser PB, Wang L, Smith JJ, Chen XS. Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer. medRxiv. e-Pub 2025. PMID: 40093220.
Omer DM, Shah F, Luthra A, Chen CT, Lee CI, Williams H, Walch H, Verheij FS, Rosen R, Alvarez J, Firat C, Karagkounis G, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Smith JJ, Chatila WK, Romesser PB, Shia J, Paty PB, Garcia-Aguilar J, Sanchez-Vega F. Clinical and Genomic Characterization of Secondary Rectal Cancer After Radiotherapy for Prostate Cancer. JAMA Netw Open 8(3):e251039, 2025. e-Pub 2025. PMID: 40100215.
Rosen RY, Bercz AP, Omer DM, Verheij FS, Williams H, Malekzadeh P, Kong DL, Quezada-Diaz FF, Wei IH, Widmar M, Karagkounis G, Roth O'Brien D, Hajj C, Crane CH, Gu P, Segal NH, Shcherba M, Ganesh K, Yaeger R, Pappou E, Romesser PB, Nash GM, Saltz LB, Cercek A, Weiser MR, Gonen M, Paty PB, Garcia-Aguilar J, Smith JJ. Correlation Between Grade of Clinical Response to Neoadjuvant Therapy for Rectal Cancer and Oncologic Outcomes in the Era of Watch-and-Wait. Dis Colon Rectum 68(3):300-307, 2025. e-Pub 2025. PMID: 39808079.
Schleimer LE, Hakki L, Seier K, Seo SK, Cohen N, Usiak S, Romero T, Kamboj M, Ilagan C, Saadat LV, Alessandris R, Soares KC, Drebin J, Wei AC, Widmar M, Wei IH, Smith JJ, Pappou EP, Paty PB, Nash GM, Jarnagin WR, Garcia-Aguilar J, Gonen M, Kingham TP, Weiser MR, D'Angelica MI. Surgical Site Infections in Simultaneous Colorectal and Liver Resections for Metastatic Colorectal Adenocarcinoma. Ann Surg Oncol 32(2):1043-1053, 2025. e-Pub 2025. PMID: 39570297.
Zhang W, Wu C, Huang H, Bleu P, Zambare W, Alvarez J, Wang L, Paty PB, Romesser PB, Smith JJ, Chen XS. Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection. Transl Oncol 52:102238, 2025. e-Pub 2025. PMID: 39754813.
Zambare W, Smith JJ, Romesser PB. Leveraging a Patient-Derived Tumoroid Platform for Precision Radiotherapy: Uncovering DNA Damage Repair Inhibitor-Mediated Radiosensitization and Therapeutic Resistance in Rectal Cancer, 2025.
Feferman Y, Verheij FS, Williams H, Omer DM, Pappou EP, Wei IH, Widmar M, Nash GM, Paty PB, Smith JJ, Cercek A, Yaeger R, Segal NH, Romesser PB, Crane C, Saltz LB, Weiser MR, Garcia-Aguilar J. Outcomes of Distal Rectal Cancer Patients Who Did Not Qualify for Watch-and-Wait: Comparison of Intersphincteric Resection Versus Abdominoperineal Resection. Ann Surg Oncol 32(1):128-136, 2025. e-Pub 2025. PMID: 39395915.
Judge SJ, Malekzadeh P, Corines MJ, Gollub MJ, Horvat N, Gonen M, Saltz L, Cercek A, Romesser P, Crane C, Shia J, Wei I, Widmar M, Pappou E, Nash GM, Smith JJ, Paty PB, Garcia-Aguilar J, Weiser MR. Watch and wait in rectal cancer patients with residual mucin on magnetic resonance imaging following neoadjuvant therapy. J Natl Cancer Inst 116(11):1761-1766, 2024. e-Pub 2024. PMID: 38937278.
Bercz A, Park BK, Pappou E, Nemirovsky D, Sarkar R, Yamner M, Omer D, Verheij FS, Alvarez J, Atri P, Reyngold M, Yaeger R, Wei IH, Wu A, Raj N, Widmar M, Hajj C, Kim MJ, Rao D, Nash GM, Williams V, Shia J, Segal NH, Diaz L, Ganesh K, Weiser MR, Gollub MJ, Paty PB, Horvat N, Zinovoy M, Roth O'Brien D, Sanchez-Vega F, Saltz LB, Crane CH, Cercek A, Gonen M, Garcia-Aguilar J, Smith JJ, Romesser PB. Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy. Ann Oncol 35(11):1003-1014, 2024. e-Pub 2024. PMID: 39266364.
Williams H, Thompson HM, Lee C, Rangnekar A, Gomez JT, Widmar M, Wei IH, Pappou EP, Nash GM, Weiser MR, Paty PB, Smith JJ, Veeraraghavan H, Garcia-Aguilar J. Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network. Ann Surg Oncol 31(10):6443-6451, 2024. e-Pub 2024. PMID: 38700799.
Liu S, Pappou EP, Cadwell JB, Kwon S, Seier K, Tan KS, Malhotra VT, Wei IH, Widmar M, Smith JJ, Afonso AM. Comparison of perioperative outcomes between colorectal operations performed on weekends vs those performed on weekdays. J Gastrointest Surg 28(10):1661-1664, 2024. e-Pub 2024. PMID: 39089487.
Xu C, Xia P, Li J, Lewis KB, Ciombor KK, Wang L, Smith JJ, Beauchamp RD, Chen XS. Discovery and validation of a 10-gene predictive signature for response to adjuvant chemotherapy in stage II and III colon cancer. Cell Rep Med 5(8):101661, 2024. e-Pub 2024. PMID: 39059386.
Bektas AB, Hakki L, Khan A, Widmar M, Wei IH, Pappou E, Smith JJ, Nash GM, Paty PB, Garcia-Aguilar J, Cercek A, Stadler Z, Segal NH, Shia J, Gonen M, Weiser MR. Clinical Calculator for Predicting Freedom From Recurrence After Resection of Stage I-III Colon Cancer in Patients With Microsatellite Instability. JCO Clin Cancer Inform 8:e2300233, 2024. e-Pub 2024. PMID: 39121392.
Alvarez JA, Shi Q, Dasari A, Garcia-Aguilar J, Sanoff H, George TJ, Hong T, Yothers G, Philip P, Nelson G, Al Baghdadi T, Alese OB, Zambare W, Omer D, Verheij FS, Bercz A, Kim MJ, Buckley J, Williams H, George M, Garcia R, Gallagher P, O'Reilly EM, Meyerhardt JA, Crawley J, Shergill A, Horvat N, Romesser PB, Hall W, Smith JJ. Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. BMC Cancer 24(1):901, 2024. e-Pub 2024. PMID: 39060961.
Lieb DA 2nd, M Thompson H, Verheij FS, Shia J, Sanchez-Vega F, Karagkounis G, Widmar M, Wei IH, Smith JJ, Nash GM, Weiser MR, Paty PB, Cercek A, Saltz LB, Garcia-Aguilar J, Pappou E. Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes. Cancers (Basel) 16(15), 2024. e-Pub 2024. PMID: 39123369.
Custers PA, Beets GL, Bach SP, Blomqvist LK, Figueiredo N, Gollub MJ, Martling A, Melenhorst J, Ortega CD, Perez RO, Smith JJ, Lambregts DMJ, Beets-Tan RGH, Maas M. An International Expert-Based Consensus on the Definition of a Clinical Near-Complete Response After Neoadjuvant (Chemo)radiotherapy for Rectal Cancer. Dis Colon Rectum 67(6):782-795, 2024. e-Pub 2024. PMID: 38701503.
O'Brien T, Hospers G, Conroy T, Lenz HJ, Smith JJ, Andrews E, O'Neill B, Leonard G. The role of total neoadjuvant therapy in locally advanced rectal cancer: a survey of specialists attending the All-Ireland Colorectal Cancer Conference 2022 including lead investigators of OPRA, PRODIGE-23 and RAPIDO. Ir J Med Sci 193(3):1183-1190, 2024. e-Pub 2024. PMID: 38141097.
Adames A, O'Brien DR, Kelly AR, Saltz LB, Garcia-Aguilar J, Zinovoy M, Williams V, Wu A, Reyngold M, Hajj C, Crane C, Cercek A, Smith JJ, Markova A, Cuaron J, McCann P, Romesser PB. Penile-scrotal erythrodysesthesia among rectal cancer patients receiving fluoropyrimidine-based chemoradiation: a case report series. Int J Colorectal Dis 39(1):75, 2024. e-Pub 2024. PMID: 38780794.
Beets NRA, Verheij FS, Williams H, Omer DM, Lin ST, Qin LX, Beets GL, Beets-Tan RGH, Wei IH, Widmar M, Pappou EP, Weiser MR, Nash GM, Smith JJ, Paty PB, Miranda J, Kim TH, Gollub MJ, Garcia-Aguilar J. Association of Lateral Pelvic Lymph Nodes with Disease Recurrence and Organ Preservation in Patients with Distal Rectal Adenocarcinoma Treated with Total Neoadjuvant Therapy. Ann Surg, 2024. e-Pub 2024. PMID: 38647132.
Rosen R, Quezada-Diaz FF, Gonen M, Karagkounis G, Widmar M, Wei IH, Smith JJ, Nash GM, Weiser MR, Paty PB, Cercek A, Romesser PB, Sanchez-Vega F, Adileh M, Roth O'Brien D, Hajj C, Williams VM, Shcherba M, Gu P, Crane C, Saltz LB, Garcia Aguilar J, Pappou E. Oncologic Outcomes of Salvage Abdominoperineal Resection for Anal Squamous Cell Carcinoma Initially Managed with Chemoradiation. J Clin Med 13(8), 2024. e-Pub 2024. PMID: 38673429.
Feferman Y, Rosen RY, Gebran S, Yuval JB, Kerioui M, Gonen M, Wei IH, Widmar M, Nash GM, Weiser MR, Paty PB, Hajj C, Roth O'Brien DA, Romesser PB, Crane CH, Smith JJ, Garcia Aguilar J, Pappou EP. Anal Adenocarcinoma Treated in the Era of Total Neoadjuvant Therapy and Nonoperative Management. Dis Colon Rectum 67(4):496-504, 2024. e-Pub 2024. PMID: 38127627.
Alvarez J, et al SJ. The Janus Rectal Cancer Trial: a phase II/III randomized controlled trial comparing clinical complete response rates in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy and mFOLFIRINOX versus mFOLFOX6. medRxiv, 2024.
Fokas E, Smith JJ, Garcia-Aguilar J, Glynne-Jones R, Buyse M, Rodel C. Early Efficacy End Points in Neoadjuvant Rectal Cancer Trials: Surrogacy Revisited. J Clin Oncol 42(8):872-875, 2024. e-Pub 2024. PMID: 37890124.
Hakki L, Khan A, Do E, Gonen M, Firat C, Vakiani E, Shia J, Widmar M, Wei IH, Smith JJ, Pappou EP, Nash GM, Paty PB, Garcia-Aguilar J, Weiser MR. Tumour deposits are independently associated with recurrence in colon cancer. Colorectal Dis 26(3):459-465, 2024. e-Pub 2024. PMID: 38263577.
Verheij FS, Omer DM, Williams H, Lin ST, Qin LX, Buckley JT, Thompson HM, Yuval JB, Kim JK, Dunne RF, Marcet J, Cataldo P, Polite B, Herzig DO, Liska D, Oommen S, Friel CM, Ternent C, Coveler AL, Hunt S, Gregory A, Varma MG, Bello BL, Carmichael JC, Krauss J, Gleisner A, Guillem JG, Temple L, Goodman KA, Segal NH, Cercek A, Yaeger R, Nash GM, Widmar M, Wei IH, Pappou EP, Weiser MR, Paty PB, Smith JJ, Wu AJ, Gollub MJ, Saltz LB, Garcia-Aguilar J. Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial. J Clin Oncol 42(5):500-506, 2024. e-Pub 2024. PMID: 37883738.
Khan A, Thompson HM, Hsu M, Widmar M, Wei IH, Pappou E, Smith JJ, Nash GM, Paty PB, Garcia-Aguilar J, Shia J, Gonen M, Weiser MR. Validation of a Clinical Calculator Predicting Freedom From Colon Cancer Recurrence After Surgery on the Basis of Molecular and Clinical Variables. Dis Colon Rectum 67(2):240-245, 2024. e-Pub 2024. PMID: 37815326.
Huang H, Wu C, Colaprico A, Bleu P, Zambare W, Alvarez J, Kim MJ, Bercz A, Wang L, Paty PB, Romesser PB, Smith J, Chen X. DISCOVERY OF ONCOGENIC MEDIATOR GENES IN RECTAL CANCER CHEMOTHERAPY RESPONSE USING GENE EXPRESSION DATA FROM MATCHED TUMOR AND PATIENT-DERIVED ORGANOID. medRxiv, 2024.
Zhang W, Wu C, Huang H, Bleu P, Zambare W, Alvarez J, Wang L, Paty PB, Romesser PB, Smith J, Chen X. Enhancing Chemotherapy Response Prediction via Matched Colorectal Tumor-Organoid Gene Expression Analysis and Network-Based Biomarker Selection. medRxiv, 2024.
Verheij FS, Yuval JB, Kok NFM, Lin ST, Qin LX, Omer DM, Thompson HM, Wei IH, Widmar M, Pappou EP, Weiser MR, Nash GM, Smith JJ, Paty PB, Beets GL, Garcia-Aguilar J. Nonoperative management of the primary tumor in patients with unresectable stage IV colon cancer treated with systemic chemotherapy: Higher complication rates for left-sided colon tumors. Eur J Surg Oncol 50(1):107294, 2024. e-Pub 2024. PMID: 38039906.
Kennecke HF, Auer R, Cho M, Dasari NA, Davies-Venn C, Eng C, Dorth J, Garcia-Aguilar J, George M, Goodman KA, Kreppel L, Meyer JE, Monzon J, Saltz L, Schrag D, Smith JJ, Zell JA, Das P. NCI Rectal-Anal Task Force consensus recommendations for design of clinical trials in rectal cancer. J Natl Cancer Inst 115(12):1457-1464, 2023. e-Pub 2023. PMID: 37535679.
Narasimhan V, Smith JJ. The LASRE trial: further support for laparoscopic total mesorectal excision?. Chin Clin Oncol 12(6):58, 2023. e-Pub 2023. PMID: 37691346.
Hakki L, Khan A, Gonen M, Stadler Z, Segal NH, Shia J, Widmar M, Wei IH, Smith JJ, Pappou EP, Nash GM, Paty PB, Garcia-Aguilar J, Weiser MR. Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer. Ann Surg Oncol 30(13):8487-8494, 2023. e-Pub 2023. PMID: 37700171.
Fokas E, Rodel C, Smith JJ, Garcia-Aguilar J, Buyse M, Glynne-Jones R. Disease-free survival as the endpoint in multimodal rectal cancer trials: have we got this right?. Lancet Gastroenterol Hepatol 8(11):962-964, 2023. e-Pub 2023. PMID: 37625428.
Yuval JB, Thompson HM, Verheij FS, Fiasconaro M, Patil S, Widmar M, Wei IH, Pappou EP, Smith JJ, Nash GM, Weiser MR, Paty PB, Garcia-Aguilar J. Comparison of Robotic, Laparoscopic, and Open Resections of Nonmetastatic Colon Cancer. Dis Colon Rectum 66(10):1347-1358, 2023. e-Pub 2023. PMID: 36649145.
Thompson HM, Bates DDB, Pernicka JG, Park SJ, Nourbakhsh M, Fuqua JL 3rd, Fiasconaro M, Lavery JA, Wei IH, Pappou EP, Smith JJ, Nash GM, Weiser MR, Paty PB, Garcia-Aguilar J, Widmar M. MRI Assessment of Extramural Venous Invasion Before and After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer and Its Association with Disease-Free and Overall Survival. Ann Surg Oncol 30(7):3957-3965, 2023. e-Pub 2023. PMID: 36964328.
Roberson JL, Maguire LH, Mitchem JB, Regenbogen SE, Smith JJ, Huang E. The Specific Aims Page: A Primer. Dis Colon Rectum 66(5):623-625, 2023. e-Pub 2023. PMID: 36745112.
Maguire LH, Mitchem JB, Smith JJ. CREATEing Community for Colorectal Surgeon-Scientists. Dis Colon Rectum 66(4):491-492, 2023. e-Pub 2023. PMID: 36689561.
Hall WA, Smith JJ. Achieving a Cure Without Total Mesorectal Excision in Rectal Adenocarcinoma. J Clin Oncol 41(2):173-180, 2023. e-Pub 2023. PMID: 36332177.
Kim JK, Wu C, Del Latto M, Gao Y, Choi SH, Kierstead M, Gabriel Sauve CE, Firat C, Perez AC, Sillanpaa J, Chen CT, Lawrence KE, Paty PB, Barriga FM, Wilkinson JE, Shia J, Sawyers CL, Lowe SW, Garcia-Aguilar J, Romesser PB, Smith JJ. An immunocompetent rectal cancer model to study radiation therapy. Cell Rep Methods 2(12):100353, 2022. e-Pub 2022. PMID: 36590695.
Yuval JB, Thompson HM, Fiasconaro M, Patil S, Wei IH, Pappou EP, Smith JJ, Guillem JG, Nash GM, Weiser MR, Paty PB, Garcia-Aguilar J, Widmar M. Predictors of operative difficulty in robotic low anterior resection for rectal cancer. Colorectal Dis 24(11):1318-1324, 2022. e-Pub 2022. PMID: 35656853.
Falcone M, Uribe AH, Papalazarou V, Newman AC, Athineos D, Stevenson K, Sauve CG, Gao Y, Kim JK, Del Latto M, Kierstead M, Wu C, Smith JJ, Romesser PB, Chalmers AJ, Blyth K, Maddocks ODK. Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. Br J Cancer 127(10):1773-1786, 2022. e-Pub 2022. PMID: 36115879.
Weiser MR, Chou JF, Kim JK, Widmar M, Wei IH, Pappou EP, Smith JJ, Nash GM, Paty PB, Cercek A, Saltz LB, Romesser PB, Crane CH, Garcia-Aguilar J, Schrag D, Gonen M. A Dynamic Clinical Calculator for Estimating Conditional Recurrence-Free Survival After Total Neoadjuvant Therapy for Rectal Cancer and Either Surgery or Watch-and-Wait Management. JAMA Netw Open 5(9):e2233859, 2022. e-Pub 2022. PMID: 36173634.
Romesser PB, Smith JJ. Inhibiting TGF-beta to increase response rates to chemoradiotherapy in rectal cancer. Lancet Oncol 23(9):1116-1118, 2022. e-Pub 2022. PMID: 36055299.
Griffith BD, Turcotte S, Lazarus J, Lima F, Bell S, Delrosario L, McGue J, Krishnan S, Oneka MD, Nathan H, Smith JJ, D'Angelica MI, Shia J, Di Magliano MP, Rao A, Frankel TL. MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment. Cancers (Basel) 14(17), 2022. e-Pub 2022. PMID: 36077630.
Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, Verheij FS, Omer DM, Lee M, Dunne RF, Marcet J, Cataldo P, Polite B, Herzig DO, Liska D, Oommen S, Friel CM, Ternent C, Coveler AL, Hunt S, Gregory A, Varma MG, Bello BL, Carmichael JC, Krauss J, Gleisner A, Paty PB, Weiser MR, Nash GM, Pappou E, Guillem JG, Temple L, Wei IH, Widmar M, Lin S, Segal NH, Cercek A, Yaeger R, Smith JJ, Goodman KA, Wu AJ, Saltz LB. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J Clin Oncol 40(23):2546-2556, 2022. e-Pub 2022. PMID: 35483010.
Choi SH, Kim JK, Chen CT, Wu C, Marco MR, Barriga FM, O'Rourke K, Pelossof R, Qu X, Chang Q, de Stanchina E, Shia J, Smith JJ, Sanchez-Vega F, Garcia-Aguilar J. KRAS Mutants Upregulate Integrin beta4 to Promote Invasion and Metastasis in Colorectal Cancer. Mol Cancer Res 20(8):1305-1319, 2022. e-Pub 2022. PMID: 35394541.
Chatila WK, Kim JK, Walch H, Marco MR, Chen CT, Wu F, Omer DM, Khalil DN, Ganesh K, Qu X, Luthra A, Choi SH, Ho YJ, Kundra R, Groves KI, Chow OS, Cercek A, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Paty PB, Shi Q, Vakiani E, Duygu Selcuklu S, Donoghue MTA, Solit DB, Berger MF, Shia J, Pelossof R, Romesser PB, Yaeger R, Smith JJ, Schultz N, Sanchez-Vega F, Garcia-Aguilar J. Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer. Nat Med 28(8):1646-1655, 2022. e-Pub 2022. PMID: 35970919.
Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr. PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer. N Engl J Med 386(25):2363-2376, 2022. e-Pub 2022. PMID: 35660797.
Hsu KS, Adileh M, Martin ML, Makarov V, Chen J, Wu C, Bodo S, Klingler S, Sauve CG, Szeglin BC, Smith JJ, Fuks Z, Riaz N, Chan TA, Nishimura M, Paty PB, Kolesnick R. Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids. Cancer Res 82(12):2298-2312, 2022. e-Pub 2022. PMID: 35472075.
Kim JK, Marco MR, Roxburgh CSD, Chen CT, Cercek A, Strombom P, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Romesser PB, Crane CH, Gollub MJ, Saltz L, Smith JJ, Weiser MR, Patil S, Garcia-Aguilar J. Survival After Induction Chemotherapy and Chemoradiation Versus Chemoradiation and Adjuvant Chemotherapy for Locally Advanced Rectal Cancer. Oncologist 27(5):380-388, 2022. e-Pub 2022. PMID: 35278070.
Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. Programme of self-reactive innate-like T cell-mediated cancer immunity. Nature 605(7908):139-145, 2022. e-Pub 2022. PMID: 35444279.
Yuval JB, Thompson HM, Firat C, Verheij FS, Widmar M, Wei IH, Pappou E, Smith JJ, Weiser MR, Paty PB, Nash GM, Shia J, Gollub MJ, Garcia-Aguilar J. MRI at Restaging After Neoadjuvant Therapy for Rectal Cancer Overestimates Circumferential Resection Margin Proximity as Determined by Comparison With Whole-Mount Pathology. Dis Colon Rectum 65(4):489-496, 2022. e-Pub 2022. PMID: 34803147.
Kim JK, Wu C, Latto MD, Gao Y, Firat C, Choi S, Chen C, Lawrence KE, Sauve C, Kierstead M, Perez AC, Jeong J, Lowe SW, Sawyer C, Garcia-Aguilar J, Romesser PB, Smith J. A Clinically Relevant Radiation Delivery System in an Immunocompetent Rectal Cancer Murine Model to Study Tumorigenesis and the Tumor Microenvironment. Original submission (prior to submission to Cell Reports Methods). bioRxiv, 2022.
Ecker BL, Shin P, Saadat LV, Court CM, Balachandran VP, Chandwani R, Drebin JA, Jarnagin WR, Kingham TP, Soares KC, Vakiani E, Wei AC, Kemeny NE, Smith JJ, Gonen M, D'Angelica MI. Genomic Stratification of Resectable Colorectal Liver Metastasis Patients and Implications for Adjuvant Therapy and Survival. Ann Surg 275(2):371-381, 2022. e-Pub 2022. PMID: 34793355.
Kim JK, Thompson H, Jimenez-Rodriguez RM, Wu F, Sanchez-Vega F, Nash GM, Guillem JG, Paty PB, Wei IH, Pappou EP, Widmar M, Weiser MR, Smith JJ, Garcia-Aguilar J. Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival. Ann Surg Oncol 29(2):1172-1179, 2022. e-Pub 2022. PMID: 34601641.
Szeglin BC, Wu C, Marco MR, Park HS, Zhang Z, Zhang B, Garcia-Aguilar J, Beauchamp RD, Chen XS, Smith JJ. A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer. Cancer Rep (Hoboken) 5(1):e1423, 2022. e-Pub 2022. PMID: 34114372.
Kim JK, Qu X, Chen CT, Smith JJ, Sanchez-Vega F, Garcia-Aguilar J. Identifying Diagnostic MicroRNAs and Investigating Their Biological Implications in Rectal Cancer. JAMA Netw Open 4(12):e2136913, 2021. e-Pub 2021. PMID: 34860243.
Jimenez-Rodriguez RM, Quezada-Diaz F, Hameed I, Kalabin A, Patil S, Smith JJ, Garcia-Aguilar J. Organ Preservation in Patients with Rectal Cancer Treated with Total Neoadjuvant Therapy. Dis Colon Rectum 64(12):1463-1470, 2021. e-Pub 2021. PMID: 34508014.
Jimenez-Rodriguez RM, Yuval JB, Sauve CG, Wasserman I, Aggarwal P, Romesser PB, Crane CH, Yaeger R, Cercek A, Guillem JG, Weiser MR, Wei IH, Widmar M, Nash GM, Pappou EP, Garcia-Aguilar J, Gollub MJ, Paty PB, Smith JJ. Type of recurrence is associated with disease-free survival after salvage surgery for locally recurrent rectal cancer. Int J Colorectal Dis 36(12):2603-2611, 2021. e-Pub 2021. PMID: 34296325.
Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, Palmaira L, Maio A, Kemel Y, Srinivasan P, Bandlamudi C, Salo-Mullen E, Tejada PR, Belanfanti K, Galle J, Joseph V, Segal N, Varghese A, Reidy-Lagunes D, Shia J, Vakiani E, Mondaca S, Mendelsohn R, Lumish MA, Steinruecke F, Kemeny N, Connell L, Ganesh K, Markowitz A, Nash G, Guillem J, Smith JJ, Paty PB, Zhang L, Mandelker D, Birsoy O, Robson M, Offit K, Taylor B, Berger M, Solit D, Weiser M, Saltz LB, Aguilar JG, Schultz N, Diaz LA, Stadler ZK. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J Natl Cancer Inst 113(12):1683-1692, 2021. e-Pub 2021. PMID: 34405229.
Alatise OI, Knapp GC, Sharma A, Chatila WK, Arowolo OA, Olasehinde O, Famurewa OC, Omisore AD, Komolafe AO, Olaofe OO, Katung AI, Ibikunle DE, Egberongbe AA, Olatoke SA, Agodirin SO, Adesiyun OA, Adeyeye A, Kolawole OA, Olakanmi AO, Arora K, Constable J, Shah R, Basunia A, Sylvester B, Wu C, Weiser MR, Seier K, Gonen M, Stadler ZK, Kemel Y, Vakiani E, Berger MF, Chan TA, Solit DB, Shia J, Sanchez-Vega F, Schultz N, Brennan M, Smith JJ, Kingham TP. Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nat Commun 12(1):6821, 2021. e-Pub 2021. PMID: 34819518.
Jimenez-Rodriguez RM, Flynn J, Patil S, Widmar M, Quezada-Diaz F, Lynn P, Strombom P, Temple L, Smith JJ, Wei IH, Pappou EP, Guillem JG, Paty PP, Nash GM, Weiser MR, Garcia-Aguilar J. Comparing outcomes of robotic versus open mesorectal excision for rectal cancer. BJS Open 5(6), 2021. e-Pub 2021. PMID: 35040943.
Widmar M, Keskin M, Strombom PD, Gennarelli RL, Szeglin BC, Smith JJ, Nash GM, Weiser MR, Paty PB, Russell D, Garcia-Aguilar J. Evaluating the Validity of the Clavien-Dindo Classification in Colectomy Studies: A 90-Day Cost of Care Analysis. Dis Colon Rectum 64(11):1426-1434, 2021. e-Pub 2021. PMID: 34623350.
Kim JK, Marco MR, Choi SH, Qu X, Chen CT, Elkabets M, Fairchild L, Chow O, Barriga FM, Dow LE, O'Rourke K, Szeglin B, Yarilin D, Fujisawa S, Manova-Todorova K, Paty PB, Shia J, Leslie C, Smith JJ, Lowe S, Pelossof R, Sanchez-Vega F, Garcia-Aguilar J. KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Mol Oncol 15(10):2766-2781, 2021. e-Pub 2021. PMID: 33817986.
Gowrikumar S, Primeaux M, Pravoverov K, Wu C, Szeglin BC, Sauve CG, Thapa I, Bastola D, Chen XS, Smith JJ, Singh AB, Dhawan P. A Claudin-Based Molecular Signature Identifies High-Risk, Chemoresistant Colorectal Cancer Patients. Cells 10(9), 2021. e-Pub 2021. PMID: 34571860.
Ibraheem A, Pillai C, Okoye I, Smith JJ, Reidy-Lagunes D, Macaulay G, Alatise O. Cancer Clinical Trials in Africa-An Untapped Opportunity: Recommendations From AORTIC 2019 Conference Special Interest Group in Clinical Trials. JCO Glob Oncol 7:1358-1363, 2021. e-Pub 2021. PMID: 34506222.
Vyas M, Firat C, Hechtman JF, Weiser MR, Yaeger R, Vanderbilt C, Benhamida JK, Keshinro A, Zhang L, Ntiamoah P, Gonzalez M, Andrade R, El Dika I, Markowitz AJ, Smith JJ, Garcia-Aguilar J, Vakiani E, Klimstra DS, Stadler ZK, Shia J. Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: frequency, patterns, and molecular etiologies. Fam Cancer 20(3):201-213, 2021. e-Pub 2021. PMID: 33033905.
Weiser MR, Hsu M, Bauer PS, Chapman WC Jr, Gonzalez IA, Chatterjee D, Lingam D, Mutch MG, Keshinro A, Shia J, Vakiani E, Konishi T, Shimada Y, Stadler Z, Segal NH, Cercek A, Saltz L, Yaeger R, Varghese A, Widmar M, Wei IH, Pappou EP, Smith JJ, Nash G, Paty P, Garcia-Aguilar J, Gonen M. Clinical Calculator Based on Molecular and Clinicopathologic Characteristics Predicts Recurrence Following Resection of Stage I-III Colon Cancer. J Clin Oncol 39(8):911-919, 2021. e-Pub 2021. PMID: 33439688.
Valero C, Lee M, Hoen D, Weiss K, Kelly DW, Adusumilli PS, Paik PK, Plitas G, Ladanyi M, Postow MA, Ariyan CE, Shoushtari AN, Balachandran VP, Hakimi AA, Crago AM, Long Roche KC, Smith JJ, Ganly I, Wong RJ, Patel SG, Shah JP, Lee NY, Riaz N, Wang J, Zehir A, Berger MF, Chan TA, Seshan VE, Morris LGT. Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors. Nat Commun 12(1):729, 2021. e-Pub 2021. PMID: 33526794.
Tan WJ, Patil S, Guillem JG, Paty PB, Weiser MR, Nash GM, Smith JJ, Pappou EP, Wei IH, Garcia-Aguilar J. Primary Tumor-Related Complications and Salvage Outcomes in Patients with Metastatic Rectal Cancer and an Untreated Primary Tumor. Dis Colon Rectum 64(1):45-52, 2021. e-Pub 2021. PMID: 33306531.
Knapp GC, Alatise O, Olopade B, Samson M, Olasehinde O, Wuraola F, Odujoko OO, Komolafe AO, Arije OO, Castle PE, Smith JJ, Weiser MR, Kingham TP. Feasibility and performance of the fecal immunochemical test (FIT) for average-risk colorectal cancer screening in Nigeria. PLoS One 16(1):e0243587, 2021. e-Pub 2021. PMID: 33434195.
Jimenez-Rodriguez RM, Patil S, Keshinro A, Shia J, Vakiani E, Stadler Z, Segal NH, Yaeger R, Konishi T, Shimada Y, Widmar M, Wei I, Pappou E, Smith JJ, Nash G, Paty P, Garcia-Aguilar J, Weiser MR. Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer. Oncoimmunology 9(1):1841948, 2020. e-Pub 2020. PMID: 33235819.
Isom CA, Bisgaard EK, Campbell KM, Courtney C, Erickson C, Faber DA, Gauger PG, Greenberg JA, Kassam AF, Mullen JT, Phares A, Quillin RC 3rd, Salcedo ES, Schaffer AJ, Scaria D, Stahl CC, Wise PE, Kauffmann RM, Chen X, Smith JJ, Terhune KP. Does Intentional Support of Degree Programs in General Surgery Residency Affect Research Productivity or Pursuit of Academic Surgery? A Multi-Institutional Study. J Surg Educ 77(6):e34-e38, 2020. e-Pub 2020. PMID: 32843316.
Wei IH, Pappou EP, Smith JJ, Widmar M, Nash GM, Weiser MR, Paty PB, Guillem JG, Afonso A, Garcia-Aguilar J. Monitoring an Ongoing Enhanced Recovery After Surgery (ERAS) Program: Adherence Improves Clinical Outcomes in a Comparison of Three Thousand Colorectal Cases. Clin Surg 5, 2020. e-Pub 2020. PMID: 33163851.
Cercek A, Dos Santos Fernandes G, Roxburgh CS, Ganesh K, Ng S, Sanchez-Vega F, Yaeger R, Segal NH, Reidy-Lagunes DL, Varghese AM, Markowitz A, Wu C, Szeglin B, Sauve CG, Salo-Mullen E, Tran C, Patel Z, Krishnan A, Tkachuk K, Nash GM, Guillem J, Paty PB, Shia J, Schultz N, Garcia-Aguilar J, Diaz LA, Goodman K, Saltz LB, Weiser MR, Smith JJ, Stadler ZK. Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy. Clin Cancer Res 26(13):3271-3279, 2020. e-Pub 2020. PMID: 32144135.
Romesser PB, Wu AJ, Cercek A, Smith JJ, Weiser M, Saltz L, Garcia-Aguilar J, Crane CH. Management of Locally Advanced Rectal Cancer During The COVID-19 Pandemic: A Necessary Paradigm Change at Memorial Sloan Kettering Cancer Center. Adv Radiat Oncol 5(4):687-689, 2020. e-Pub 2020. PMID: 32322758.
Quezada-Diaz FF, Smith JJ, Jimenez-Rodriguez RM, Wasserman I, Pappou EP, Patil S, Wei IH, Nash GM, Guillem JG, Weiser MR, Paty PB, Garcia-Aguilar J. Patient-Reported Bowel Function in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy After Neoadjuvant Therapy: A Case-Control Study. Dis Colon Rectum 63(7):897-902, 2020. e-Pub 2020. PMID: 32217857.
Widmar M, Aggarwal P, Keskin M, Strombom PD, Patil S, Smith JJ, Nash GM, Garcia-Aguilar J. Intracorporeal Anastomoses in Minimally Invasive Right Colectomies Are Associated With Fewer Incisional Hernias and Shorter Length of Stay. Dis Colon Rectum 63(5):685-692, 2020. e-Pub 2020. PMID: 32168093.
Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano A, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG. Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status. J Am Coll Surg 230(4):669-675, 2020. e-Pub 2020. PMID: 32007537.
Szeglin B, Wu C, Marco M, Park HS, Zhang Z, Zhang B, Garcia-Aguilar J, Beauchamp R, Sawyers CL, Chen X, Smith J. A SMAD4-Modulated Gene Profile Predicts Disease-Free Survival in Stage II and III Colorectal Cancer. Original submission (prior to submission to Cancer Reports). medRxiv, 2020.
Smith JJ, Chatila WK, Sanchez-Vega F, Datta J, Connell LC, Szeglin BC, Basunia A, Boucher TM, Hauser H, Wasserman I, Wu C, Cercek A, Hechtman JF, Madden C, Jarnagin WR, Garcia-Aguilar J, D'Angelica MI, Yaeger R, Schultz N, Kemeny NE. Genomic stratification beyond Ras/B-Raf in colorectal liver metastasis patients treated with hepatic arterial infusion. Cancer Med 8(15):6538-6548, 2019. e-Pub 2019. PMID: 31503397.
Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauve CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massague J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ. A rectal cancer organoid platform to study individual responses to chemoradiation. Nat Med 25(10):1607-1614, 2019. e-Pub 2019. PMID: 31591597.
Roxburgh CSD, Strombom P, Lynn P, Cercek A, Gonen M, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Shia J, Vakiani E, Yaeger R, Stadler ZK, Segal NH, Reidy D, Varghese A, Wu AJ, Crane CH, Gollub MJ, Saltz LB, Garcia-Aguilar J, Weiser MR. Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short-term outcomes. Colorectal Dis 21(10):1140-1150, 2019. e-Pub 2019. PMID: 31108012.
Thompson JJ, Short SP, Parang B, Brown RE, Li C, Ng VH, Saito-Diaz K, Choksi YA, Washington MK, Smith JJ, Fingleton B, Brand T, Lee E, Coffey RJ, Williams CS. Blood vessel epicardial substance reduces LRP6 receptor and cytoplasmic beta-catenin levels to modulate Wnt signaling and intestinal homeostasis. Carcinogenesis 40(9):1086-1098, 2019. e-Pub 2019. PMID: 30689807.
Lazarus J, Oneka MD, Barua S, Maj T, Lanfranca MP, Delrosario L, Sun L, Smith JJ, D'Angelica MI, Shia J, Fang JM, Shi J, Di Magliano MP, Zou W, Rao A, Frankel TL. Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells. Ann Surg Oncol 26(9):2821-2830, 2019. e-Pub 2019. PMID: 31250346.
Strombom P, Widmar M, Keskin M, Gennarelli RL, Lynn P, Smith JJ, Guillem JG, Paty PB, Nash GM, Weiser MR, Garcia-Aguilar J. Assessment of the Value of Comorbidity Indices for Risk Adjustment in Colorectal Surgery Patients. Ann Surg Oncol 26(9):2797-2804, 2019. e-Pub 2019. PMID: 31209671.
Roxburgh CSD, Strombom P, Lynn P, Gonen M, Paty PB, Guillem JG, Nash GM, Smith JJ, Wei I, Pappou E, Garcia-Aguilar J, Weiser MR. Role of the Interval from Completion of Neoadjuvant Therapy to Surgery in Postoperative Morbidity in Patients with Locally Advanced Rectal Cancer. Ann Surg Oncol 26(7):2019-2027, 2019. e-Pub 2019. PMID: 30963399.
Konishi T, Shimada Y, Hsu M, Wei IH, Pappou E, Smith JJ, Nash GM, Guillem JG, Paty PB, Garcia-Aguilar J, Cercek A, Yaeger R, Stadler ZK, Segal NH, Varghese A, Saltz LB, Shia J, Vakiani E, Gonen M, Weiser MR. Contemporary Validation of a Nomogram Predicting Colon Cancer Recurrence, Revealing All-Stage Improved Outcomes. JNCI Cancer Spectr 3(2):pkz015, 2019. e-Pub 2019. PMID: 31119207.
Smith JJ, Strombom P, Chow OS, Roxburgh CS, Lynn P, Eaton A, Widmar M, Ganesh K, Yaeger R, Cercek A, Weiser MR, Nash GM, Guillem JG, Temple LKF, Chalasani SB, Fuqua JL, Petkovska I, Wu AJ, Reyngold M, Vakiani E, Shia J, Segal NH, Smith JD, Crane C, Gollub MJ, Gonen M, Saltz LB, Garcia-Aguilar J, Paty PB. Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy. JAMA Oncol 5(4):e185896, 2019. e-Pub 2019. PMID: 30629084.
Chow OS, Patil S, Keskin M, Smith JJ, Widmar M, Smith DD, Avila K, Shia J, Chu P, Garcia-Aguilar J. Variation in the Thoroughness of Pathologic Assessment and Response Rates of Locally Advanced Rectal Cancers After Chemoradiation. J Gastrointest Surg 23(4):794-799, 2019. e-Pub 2019. PMID: 30719677.
Wasserman I, Lee LH, Ogino S, Marco MR, Wu C, Chen X, Datta J, Sadot E, Szeglin B, Guillem JG, Paty PB, Weiser MR, Nash GM, Saltz L, Barlas A, Manova-Todorova K, Uppada SPB, Elghouayel AE, Ntiamoah P, Glickman JN, Hamada T, Kosumi K, Inamura K, Chan AT, Nishihara R, Cercek A, Ganesh K, Kemeny NE, Dhawan P, Yaeger R, Sawyers CL, Garcia-Aguilar J, Giannakis M, Shia J, Smith JJ. SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance. Clin Cancer Res 25(6):1948-1956, 2019. e-Pub 2019. PMID: 30587545.
Gollub MJ, Blazic I, Felder S, Knezevic A, Gonen M, Garcia-Aguilar J, Paty PP, Smith JJ. Value of adding dynamic contrast-enhanced MRI visual assessment to conventional MRI and clinical assessment in the diagnosis of complete tumour response to chemoradiotherapy for rectal cancer. Eur Radiol 29(3):1104-1113, 2019. e-Pub 2019. PMID: 30242504.
Hoehn RS, Smith JJ. Adjuvant Chemotherapy for Colon Cancer. Dis Colon Rectum 62(3):274-278, 2019. e-Pub 2019. PMID: 30741766.
Liu S, Gӧnen M, Stadler ZK, Weiser MR, Hechtman JF, Vakiani E, Wang T, Vyas M, Joneja U, Al-Bayati M, Segal NH, Smith JJ, King S, Guercio S, Ntiamoah P, Markowitz AJ, Zhang L, Cercek A, Garcia-Aguilar J, Saltz LB, Diaz LA, Klimstra DS, Shia J. Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. Mod Pathol 32(1):110-121, 2019. e-Pub 2019. PMID: 30166615.
Lazarus J, Maj T, Smith JJ, Perusina Lanfranca M, Rao A, D'Angelica MI, Delrosario L, Girgis A, Schukow C, Shia J, Kryczek I, Shi J, Wasserman I, Crawford H, Nathan H, Pasca Di Magliano M, Zou W, Frankel TL. Spatial and phenotypic immune profiling of metastatic colon cancer. JCI Insight 3(22), 2018. e-Pub 2018. PMID: 30429368.
Weiser MR, Gonen M, Usiak S, Pottinger T, Samedy P, Patel D, Seo S, Smith JJ, Guillem JG, Temple L, Nash GM, Paty PB, Baldwin-Medsker A, Cheavers CE, Eagan J, Garcia-Aguilar J. Effectiveness of a multidisciplinary patient care bundle for reducing surgical-site infections. Br J Surg 105(12):1680-1687, 2018. e-Pub 2018. PMID: 29974946.
Uppada SB, Gowrikumar S, Ahmad R, Kumar B, Szeglin B, Chen X, Smith JJ, Batra SK, Singh AB, Dhawan P. MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/beta-catenin signaling. Mol Cancer 17(1):111, 2018. e-Pub 2018. PMID: 30068336.
Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR. Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer. JAMA Oncol 4(6):e180071, 2018. e-Pub 2018. PMID: 29566109.
Konishi T, Shimada Y, Lee LH, Cavalcanti MS, Hsu M, Smith JJ, Nash GM, Temple LK, Guillem JG, Paty PB, Garcia-Aguilar J, Vakiani E, Gonen M, Shia J, Weiser MR. Poorly Differentiated Clusters Predict Colon Cancer Recurrence: An In-Depth Comparative Analysis of Invasive-Front Prognostic Markers. Am J Surg Pathol 42(6):705-714, 2018. e-Pub 2018. PMID: 29624511.
Konishi T, Shimada Y, Hsu M, Tufts L, Jimenez-Rodriguez R, Cercek A, Yaeger R, Saltz L, Smith JJ, Nash GM, Guillem JG, Paty PB, Garcia-Aguilar J, Gonen M, Weiser MR. Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome. JAMA Oncol 4(3):309-315, 2018. e-Pub 2018. PMID: 29270608.
Horvat N, Raj A, Ward JM, Smith JJ, Markowitz AJ, Gollub MJ. Clinical Value of CT Colonography Versus Preoperative Colonoscopy in the Surgical Management of Occlusive Colorectal Cancer. AJR Am J Roentgenol 210(2):333-340, 2018. e-Pub 2018. PMID: 29261351.
Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6(3):257-276, 2018. e-Pub 2018. PMID: 30109253.
Widmar M, Keskin M, Strombom P, Beltran P, Chow OS, Smith JJ, Nash GM, Shia J, Russell D, Garcia-Aguilar J. Lymph node yield in right colectomy for cancer: a comparison of open, laparoscopic and robotic approaches. Colorectal Dis 19(10):888-894, 2017. e-Pub 2017. PMID: 28649796.
McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight 2(16), 2017. e-Pub 2017. PMID: 28814670.
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Gut 66(5):852-862, 2017. e-Pub 2017. PMID: 28389570.
Smith JJ, Wasserman I, Milgrom SA, Chow OS, Chen CT, Patil S, Goodman KA, Garcia-Aguilar J. Single Nucleotide Polymorphism TGFbeta1 R25P Correlates with Acute Toxicity during Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients. Int J Radiat Oncol Biol Phys 97(5):924-930, 2017. e-Pub 2017. PMID: 28333014.
Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS. Myeloid translocation genes differentially regulate colorectal cancer programs. Oncogene 35(49):6341-6349, 2016. e-Pub 2016. PMID: 27270437.
Lee LH, Cavalcanti MS, Segal NH, Hechtman JF, Weiser MR, Smith JJ, Garcia-Aguilar J, Sadot E, Ntiamoah P, Markowitz AJ, Shike M, Stadler ZK, Vakiani E, Klimstra DS, Shia J. Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Mod Pathol 29(11):1433-1442, 2016. e-Pub 2016. PMID: 27443512.
Patel SV, Roxburgh CS, Vakiani E, Shia J, Smith JJ, Temple LK, Paty P, Garcia-Aguilar J, Nash G, Guillem J, Wu A, Reyngold M, Weiser MR. Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer. J Surg Oncol 114(5):637-641, 2016. e-Pub 2016. PMID: 27641934.
Chow OS, Kuk D, Keskin M, Smith JJ, Camacho N, Pelossof R, Chen CT, Chen Z, Avila K, Weiser MR, Berger MF, Patil S, Bergsland E, Garcia-Aguilar J. KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy. Ann Surg Oncol 23(8):2548-55, 2016. e-Pub 2016. PMID: 27020587.
Pelossof R, Chow OS, Fairchild L, Smith JJ, Setty M, Chen CT, Chen Z, Egawa F, Avila K, Leslie CS, Garcia-Aguilar J. Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer. Genes Chromosomes Cancer 55(4):311-321, 2016. e-Pub 2016. PMID: 26865277.
Smith JJ, Chow OS, Gollub MJ, Nash GM, Temple LK, Weiser MR, Guillem JG, Paty PB, Avila K, Garcia-Aguilar J. Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management. BMC Cancer 15:767, 2015. e-Pub 2015. PMID: 26497495.
Bhat AA, Pope JL, Smith JJ, Ahmad R, Chen X, Washington MK, Beauchamp RD, Singh AB, Dhawan P. Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis. Oncogene 34(35):4570-80, 2015. e-Pub 2015. PMID: 25500541.
Williams CS, Bernard JK, Demory Beckler M, Almohazey D, Washington MK, Smith JJ, Frey MR. ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis 36(7):710-8, 2015. e-Pub 2015. PMID: 25916654.
Sopha SC, Rosado FG, Smith JJ, Merchant NB, Shi C. Hepatic uterus-like mass misdiagnosed as hepatic abscess. Int J Surg Pathol 23(2):134-9, 2015. e-Pub 2015. PMID: 24827588.
Smith JJ, Patel RK, Chen X, Tarpley MJ, Terhune KP. Does intentional support of degree programs in general surgery residency affect research productivity or pursuit of academic surgery?. J Surg Educ 71(4):486-91, 2014. e-Pub 2014. PMID: 24794064.
Smith JJ, Chen X, Schneider DF, Broome JT, Sippel RS, Chen H, Solorzano CC. Cancer after thyroidectomy: a multi-institutional experience with 1,523 patients. J Am Coll Surg 216(4):571-7; discussion 577-9, 2013. e-Pub 2013. PMID: 23403140.
Smith JJ, Chen X, Schneider DF, Nookala R, Broome JT, Sippel RS, Chen H, Solorzano CC. Toxic nodular goiter and cancer: a compelling case for thyroidectomy. Ann Surg Oncol 20(4):1336-40, 2013. e-Pub 2013. PMID: 23108556.
Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res 73(3):1245-55, 2013. e-Pub 2013. PMID: 23221387.
Oh SC, Park YY, Park ES, Lim JY, Kim SM, Kim SB, Kim J, Kim SC, Chu IS, Smith JJ, Beauchamp RD, Yeatman TJ, Kopetz S, Lee JS. Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut 61(9):1291-8, 2012. e-Pub 2012. PMID: 21997556.
Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, Gonzalez-Angulo AM, Mills GB, Pinto JA, Gomez HL, Arteaga CL. Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Nat Med 18(7):1052-9, 2012. e-Pub 2012. PMID: 22683778.
Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, Eschrich SA, Yeatman TJ, Deane NG, Beauchamp RD. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. Gastroenterology 142(3):562-571.e2, 2012. e-Pub 2012. PMID: 22115830.
Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One 7(12):e51205, 2012. e-Pub 2012. PMID: 23251453.
Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P. Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology 141(6):2140-53, 2011. e-Pub 2011. PMID: 21878201.
Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest 121(10):4056-69, 2011. e-Pub 2011. PMID: 21911938.
Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene 30(29):3234-47, 2011. e-Pub 2011. PMID: 21383692.
Nagaraj NS, Smith JJ, Revetta F, Washington MK, Merchant NB. Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Mol Cancer Ther 9(8):2322-32, 2010. e-Pub 2010. PMID: 20682659.
Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest 120(3):840-9, 2010. e-Pub 2010. PMID: 20197623.
Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, Eschrich S, Kis C, Levy S, Washington MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology 138(3):958-68, 2010. e-Pub 2010. PMID: 19914252.
Krishnan M, Singh AB, Smith JJ, Sharma A, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD, Dhawan P. HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene 29(2):305-12, 2010. e-Pub 2010. PMID: 19881542.
Kanies CL, Smith JJ, Kis C, Schmidt C, Levy S, Khabar KS, Morrow J, Deane N, Dixon DA, Beauchamp RD. Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. Mol Cancer Res 6(7):1124-36, 2008. e-Pub 2008. PMID: 18644977.
Smith JJ, Passman MA, Dattilo JB, Guzman RJ, Naslund TC, Netterville JL. Carotid body tumor resection: does the need for vascular reconstruction worsen outcome?. Ann Vasc Surg 20(4):435-9, 2006. e-Pub 2006. PMID: 16786441.
Smith JJ, Taylor PR. Endovascular treatment of mycotic aneurysms of the thoracic and abdominal aorta: the need for level I evidence. Eur J Vasc Endovasc Surg 27(6):569-70, 2004. e-Pub 2004. PMID: 15121104.
Hassoun HT, Miller CC 3rd, Huynh TT, Estrera AL, Smith JJ, Safi HJ. Cold visceral perfusion improves early survival in patients with acute renal failure after thoracoabdominal aortic aneurysm repair. J Vasc Surg 39(3):506-12, 2004. e-Pub 2004. PMID: 14981439.
Quezada-Díaz FF, Bercz A, Romesser PB, Escobar JL, Caire N, Díaz-Feldman LE, Manriquez E, Smith J, Carvajal G. No Operation After Short-Course Radiotherapy Followed By Consolidation Chemotherapy in Locally Advanced Rectal Cancer (NOAHS-ARC): Study Protocol for a Prospective, Phase II Trial. Research Square.
Gomez JT, Rangnekar A, Williams H, Thompson H, Garcia-Aguilar J, Smith JJ, Veeraraghavan H. Deep learning classifier of locally advanced rectal cancer treatment response from endoscopy images. arXiv preprint arXiv:2405.03762.
Gomez JT, Rangnekar A, Williams H, Thompson H, Garcia-Aguilar J, Smith JJ, Veeraraghavan H. Deep learning classifier of locally advanced rectal cancer treatment response from endoscopy images. arXiv preprint arXiv:2405.03762.

Invited Articles

Ganesh† K, Wu† C, O’Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi S, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen C, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger RD, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith† J. A rectal cancer organoid platform to study individual responses to chemoradiation, 2019.
Cercek A, Dos Santos Fernandes G, Roxburgh C, Ng S, Yaeger R, Segal N, Ganesh K, Reidy D, Smith JJ, Nash GM, Guillem J, Paty PB, Shia J, Garcia-Aguilar J, Diaz L, Crane C, Goodman K, Saltz L, Weiser MR, Stadler Z. Mismatch repair deficient rectal cancer is resistant to induction combination chemotherapy. Ann Oncol 29(Suppl 8:viiii168), 2018. PMID: 32136297.
Tuft LS, Jarnagin ED, Flynn JR, Gonen M, Guillem, Paty PB, Nash GM, Smith JJ, Wei IH, Pappou E, D’Angelica MI, Allen PJ, Kingham TP, Balachandran VP, Drebin JA, Garcia-Aguilar J, Jarnagin WR, Weiser MR. A perioperative multisiciplinary care bundle reduces surgical site infections in patients undergoing synchronous colorectal and liver resection. HPB (Oxford), 2018. PMID: 300775525.

Review Articles

Khasawneh H, Khatri G, Sheedy SP, Nougaret S, Lambregts DMJ, Santiago I, Kaur H, Smith JJ, Horvat N. MRI for Rectal Cancer: Updates and Controversies-AJR Expert Panel Narrative Review. AJR Am J Roentgenol:1-16, 2025. e-Pub 2025. PMID: 39320354.
Modena Heming CA, Alvarez JA, Miranda J, Cardoso D, Almeida Ghezzi CL, Nogueira GF, Costa-Silva L, Damasceno RS, Morita TO, Smith JJ, Horvat N. Mastering rectal cancer MRI: From foundational concepts to optimal staging. Eur J Radiol 183:111937, 2025. e-Pub 2025. PMID: 39864243.
El Homsi M, Bercz A, Chahwan S, Fernandes MC, Javed-Tayyab S, Golia Pernicka JS, Nincevic J, Paroder V, Ruby L, Smith JJ, Petkovska I. Watch & wait - Post neoadjuvant imaging for rectal cancer. Clin Imaging 110:110166, 2024. e-Pub 2024. PMID: 38669916.
Jayaprakasam VS, Alvarez J, Omer DM, Gollub MJ, Smith JJ, Petkovska I. Watch-and-Wait Approach to Rectal Cancer: The Role of Imaging. Radiology 307(1):e221529, 2023. e-Pub 2023. PMID: 36880951.
Quezada-Diaz FF, Smith JJ. Neoadjuvant Therapy for Rectal Cancer. Surg Oncol Clin N Am 31(2):279-291, 2022. e-Pub 2022. PMID: 35351278.
Fokas E, Appelt A, Glynne-Jones R, Beets G, Perez R, Garcia-Aguilar J, Rullier E, Smith JJ, Marijnen C, Peters FP, van der Valk M, Beets-Tan R, Myint AS, Gerard JP, Bach SP, Ghadimi M, Hofheinz RD, Bujko K, Gani C, Haustermans K, Minsky BD, Ludmir E, West NP, Gambacorta MA, Valentini V, Buyse M, Renehan AG, Gilbert A, Sebag-Montefiore D, Rodel C. International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer. Nat Rev Clin Oncol 18(12):805-816, 2021. e-Pub 2021. PMID: 34349247.
Gosain A, Chu DI, Smith JJ, Neuman HB, Goldstein AM, Zuckerbraun BS. Climbing the grants ladder: Funding opportunities for surgeons. Surgery 170(3):707-712, 2021. e-Pub 2021. PMID: 33789813.
Quezada-Diaz FF, Smith JJ. Options for Low Rectal Cancer: Robotic Total Mesorectal Excision. Clin Colon Rectal Surg 34(5):311-316, 2021. e-Pub 2021. PMID: 34512198.
Smith JJ, Garcia-Aguilar J, Paty PB. Looking forward, not backward, on Watch and Wait for Rectal Cancer-In Reply, 2019. e-Pub 2019. PMID: 3124631.
Smith JJ, Garcia-Aguilar J. Advances and challenges in treatment of locally advanced rectal cancer. J Clin Oncol 33(16):1797-808, 2015. e-Pub 2015. PMID: 25918296.
Balachandran VP, Gonen M, Smith JJ, DeMatteo RP. Nomograms in oncology: more than meets the eye. Lancet Oncol 16(4):e173-80, 2015. e-Pub 2015. PMID: 25846097.
Smith JJ, D'Angelica MI. Surgical management of hepatic metastases of colorectal cancer. Hematol Oncol Clin North Am 29(1):61-84, 2015. e-Pub 2015. PMID: 25475573.
Smith JJ, Weiser MR. Outcomes in non-metastatic colorectal cancer. J Surg Oncol 110(5):518-26, 2014. e-Pub 2014. PMID: 24962603.
Datta J, Smith J, Chatila W, McAuliffe JC, Kandoth C, Vakiani E, Frankel TL, Ganesh K, Wasserman I, Lipsyc M, Guillem JG, Nash GM, Paty PB, Weiser MW, Saltz L, Berger MF, Jarnagin WR, Balachandran V, Kingham T, Kemeny NE, Cercek A, Garcia-Aguilar J, Taylor BS, Viale A, Yaeger R, Solit DB, Schultz N, I D’Angelica AM. Extremes of Survivorship after Resection of Colorectal Liver Metastasis Identifies a Distinct Molecular Profile Associated with Survival in Two Independent Cohorts of Colorectal Cancer Patients. Clinical Cancer Research. PMID: 31710950.

Editorials

Zambare W, Smith JJ. Near Complete Response: An Opportunity for Organ Preservation in Rectal Cancer. Ann Surg Oncol 32(7):4582-4585, 2025. PMID: 40263228.
Goffredo P, Smith JJ. The Paradox of Early Stage Rectal Cancer: More ReSeARCh in the Right Direction. Ann Surg Oncol 29(3):1513-1515, 2022. PMID: 34850305.
Smith JJ. To resect or not to resect? Insight on managing the asymptomatic primary tumor in colorectal cancer patients with synchronous unresectable metastases from the prospective.
Smith JJ, Paty PB, Garcia-Aguilar J. Watch and Wait in Rectal Cancer or More Wait and See?. JAMA Surg 155(7):657-658, 2020. PMID: 32347912.
Smith JJ, Weiser MR. Non-operative management of rectal cancer—where we stand now. For the ‘Best of Surgical Thinking’ in Scientific American Surgery.
Chow OS, Smith JJ, Gollub M, Garcia-Aguilar J. Can We Predict Response and/or Resistance to Neoadjuvant Chemoradiation in Patients with Rectal Cancer?. Current Colorectal Cancer Reports 10(2).
Smith JJ, Deane NG, Dhawan P, Beauchamp RD. Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery 144(3):353-66, 2008. PMID: 18707034.
Huynh TT, Porat EE, Miller CC 3rd, Estrera AL, Smith JJ, Safi HJ. The effect of aortic dissection on outcome in descending thoracic and thoracoabdominal aortic aneurysm repair. Semin Vasc Surg 15(2):108-15, 2002. PMID: 12060900.
Estrera AL, Huynh TT, Porat EE, Miller CC 3rd, Smith JJ, Safi HJ. Is acute type A aortic dissection a true surgical emergency?. Semin Vasc Surg 15(2):75-82, 2002. PMID: 12060896.

Abstracts

Alvarez J, Smith JJ, Tuli R, Romesser PB. Circulating tumor DNA (ctDNA) for response assessment in patients with anal cancer treated with definitive chemoradiation. Oral Presentation at GI Symposium 2023.
Smith JJ. Smad4 Suppresses Wnt Signaling Through Down-regulation of -catenin. The American Society of Clinical Investigation / The Association of American Physicians (ASCI/AAP) Joint Meeting.
Smith JJ. KRAS mutation in colorectal cancer and its association with a stromal-derived gene signature. Gastrointestinal Cancer Symposium.
Smith JJ. Tumorigenesis and Stage Progression in Rectal Cancer is Paralleled by Progressive Differential Expression in a Subset of Genes and miRNAs. Society of Surgical Oncology Annual Cancer Symposium.
Smith JJ. Molecular alteration of SMAD4 in hindgut-derived colorectal tumors identifies a distinct subset of patients and is associated with worse recurrence-free survival. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.
Smith JJ. KRAS mutation status is associated with stromal inactivation in colorectal cancer and predicts poor response to neoadjuvant chemoradiotherapy. Host-Tumor Interactions. AACR Annual Meeting.
Smith JJ. SMAD4 loss in colorectal cancer: Correlation with recurrence, chemoresistance and immune infiltrate. Gastrointestinal Cancer Symposium.
Smith JJ. Extraordinary survivorship after colorectal liver metastasis resection to identify a distinct molecular profile associated with survival in an independent cohort of 965 patients. ASCO Annual Meeting.
Smith JJ. Total neoadjuvant chemotherapy to facilitate delivery and tolerance of systemic chemotherapy and response in locally advanced rectal cancer. ASCO Annual Meeting.
Smith JJ. An endoluminal rectal cancer model establishes a platform to study individual tumor biology and responses to chemotherapy and irradiation. AACR Intestinal Stem Cells and Colon Cancer: Biology to Therapy Meeting.
Smith JJ. Initial results of the first clinical trial of a novel unidirectional permanent device for intraoperative brachytherapy 18(S12eS116).
Chatila WK, Marco MR, Qu X, Walch H, Luthra A, Chen C, J, Kundra R, Pelossof R, Schultz N, Yaeger R, Smith J, Sanchez-Vega F, Garcia-Aguilar J. Genomic characterization of rectal cancer and molecular determinants of response to neoadjuvant chemoradiotherapy. Presented at the Gastrointestinal Cancers Symposium.
Cercek A, Stadler Z, Cohen J, Weiss J, Lamendola-Essel M, Krishnan A, Yaeger R, Segal N, Connell L, El Dika I, Kemeny NK, Saltz LB, Smith JJ, Nash GM, Paty PB, Garcia-Aguilar J, Weiser MR, Diaz LA. A phase II trial study of induction PD-1 blockade in subjects with locally advanced mismatch repair-deficient rectal adenocarcinoma. American Society of Clinical Oncology Meeting 38(15).
Smith JJ. The preliminary results of the organ preservation in rectal adenocarcinoma trial (OPRA). Garcia-Aguilar J et al. Presented at the American Society of Clinical Oncology Meeting on behalf of the Rectal Cancer Consortium.
George M, Smith JJ, Miler ED, Romesser PB, Seybold N. Impact and utility of COLONTOWN, an online CRC patient and caregiver support group in clinical trial design. virtually presented at Gastrointestinal Symposium 39(3).
Szeglin B Smith JJ. Expanding a rectal cancer organoid platform to study individual responses to chemoradiation. Oncology Models Forum Annual Meeting at the National Cancer Institute (by invitation).
Romesser PB, Park K, Smith JJ. Organ preservation and total neoadjuvant therapy for rectal cancer: Investigating long-course chemoradiation versus short-course radiation therapy. Accepted for mini-oral presentation at GI Symposium 2023 and ASCO 2023.
Smith JJ, Dasari A, Shi Q, Garcia-Aguilar J, Sanoff H, George TJ, Hong TS, Yothers G, Philip PA, Nelson GD, Al Baghadi T, Lese O, O’Reilly E, Meyerhardt JA, Shergill A, Horvat N, Romesser PB, Hall WA. Alliance A022104/NRG-GI010: A randomized phase II trial testing the efficacy of triplet versus doublet chemotherapy to achieve clinical complete response in patients with locally advanced rectal cancer | The Janus Rectal Cancer Trial. Presented as Trials in Progress Poster: ASCO 2023.
Rosen R, Bercz A, Omer D, Verheij FS, Williams H, Malekzadeh P, Quezada-Diaz FF, Wei I, Widmar M, Karagkounis G, Roth O’Brien D, Hajj C, Crane C, Gu P, Segal NH, Shcherba M, Ganesh K, Yaeger R, Pappou E, Romesser PB, Nash GM, Saltz LB, Cercek A, Weiser MR, Gonen M, Paty PB, Garcia-Aguilar J, Smith JJ. Correlation Between Grade of Clinical Response to Neoadjuvant Therapy for Rectal Cancer and Oncologic Outcomes in the Era of Watch-and-Wait. Presented as a podium presentation at the annual scientific meeting of the American Society of Colon and Rectal Surgeons.
Bercz A, Smith JJ. Endoscopic Features Of Post-Treatment Rectal Strictures Correlate To Tumor Response. Oral Presentation at Academic Surgical Congress February 2025 – Paper pending May 2025.
Lumish MA, Cohen JL, Stadler ZK, Weiss JA, Lamendola-Essel MF, Yaeger R, Segal NH, El Dika IH, Saltz LB, Shcherba M, Sugarman R, Desai AM, Smith JJ, Widmar M, Pappou E, Paty P, Garcia-Aguilar J, Weiser MR, Diaz Jr LA, Cercek A. PD-1 blockade alone for mismatch repair deficient (dMMR) locally advanced rectal cancer. Submitted to the Gastrointestinal Symposium 2022 (update submitted and accepted to ASCO 2022 – simultaneous publication in NEJM 2022 (see above)).
Yuval JB, Verheij FS, Lin ST, Thompson HM, Omer DM, Kim JK, Smith JJ, Gollub MJ, L-X Q, Garcia-Aguilar J. Clinical and radiological predictors of organ preservation in rectal cancer patients treated with total neoadjuvant therapy. Accepted as Merit Award Winner ASCO 2022.
Smith JJ. An online rectal cancer tumoroid biorepository: a resource to facilitate multimodal data integration. Alvarez J et al. Accepted at the Annual GI Symposium 2024.

Book Chapters

Alvarez J, Smith JJ. Anorectal mucosal melanoma. In: Seminars in Colon and Rectal Surgery. WB Saunders, 100990, 2023.
Quezada F, Smith J J, Guillem J G. The approach to reoperative pelvic surgery in rectal cancer. In: In Fischer J. 8th. Wolters Kluwer, 1861-1867, 2022.
Quezada-Diaz F, Sammour T, Smith JJ, You N. Watch and Wait in Rectal Cancer Patients with Clinical Complete Response to Neoadjuvant Therapy. In: Comprehensive Rectal Cancer Care, 2019.
Datta J, Smith JJ. How to Set Up, Staff, and Fund Your Basic Science or Translational Research Laboratory. In: Success in Academic Surgery: Basic Science, Chapter 1, 2019.
Quezada F, Tan WJ, Smith JJ. Mesocolic Resection in Colon Cancer (Ch. 37). In: For The Mesenteric Organ in Health and Disease, 2019.
Smith J J, Guillem J G. The approach to reoperative pelvic surgery in rectal cancer. In: Fischer's Mastery of Surgery. 7th. Wolters Kluwer, 1861-1867, 2018.
Smith JJ, Feo L, Garcia-Aguilar J. Robotic LAR: a step-by-step approach in Surgery for Cancers of the Gastrointestinal Tract: A Step-by-Step Approach. Springer Science+Business Media, 2015.
Edwards C, Smith JJ, Merchant NB, Parikh A. Targeting Angiogenesis in the Treatment of Hepatic Metastasis Liver Metastasis: Biology and Clinical Management:. In: Cancer Metastasis – Biology and Treatment. Springer Science + Business Media B.V. 2011, 2011.
Alvarez J, Smith JJ. Preoperative versus postoperative chemoradiotherapy for rectal cancer in 50 Landmark Papers every Colorectal Surgeon Should Know. In: New England Journal of Medicine. 1st. CRC Press, 1731–1740, 2004.
Narasimhan V, Ooi G, Smith JJ, You YN. Adjuvant and Neoadjuvant Therapy for Colorectal Cancer: Molecular-Based Therapy including Landmark Trials for Colorectal Cancers. In: In Shackelford's Surgery of the Alimentary Tract. 9th.
Quezada F, Smith JJ. Robotic Abdominal Perineal Resection: Prone Position. In: Surgery for Cancers of the Gastrointestinal Tract: A Step-by-Step Approach.
Nahum K, Smith JJ, Jarnagin WR. Proximal Biliary Strictures Mimicking Hilar Cholangiocarcinoma in Comprehensive Management of Benign Biliary Stenosis and Injury.
Hoehne, R, Quezada F, Smith JJ. Colon Cancer. In: Complex General Surgical Oncology.
Smith JJ, Dehal A, Balch G, Garcia-Aguilar J. Colectomy in Colon Cancer Treatment. In: McGraw-Hill’s Textbook of Surgical Oncology.
Quezada F, Smith JJ. Is non-operative management of rectal cancer feasible?. In: Advances in Surgery.
Quezada F, Smith JJ. Watch and wait versus conventional surgical treatment in rectal cancer. In: Difficult Decisions in Surgery. 2nd.

Letters to the Editor

Garcia-Aguilar J, Williams H, Weiser MR, Smith JJ, Romesser PB, Crane C, Qin LX, Gonen M, Cercek A, Saltz LB. Organ Preservation in Rectal Cancer: Fear of Risks Versus the Risks of Fear. J Clin Oncol 43: 1745-1746, 2025.
Bercz A, Smith JJ, Romesser PB. Reply to the Letter to the Editor 'Circulating tumor DNA after definitive therapy for locally advanced rectal cancer' by Drs Sorscher and Rocha Lima. Ann Oncol 36: 224-225, 2025.
Thompson HM, Williams H, Omer DM, Yuval JB, Verheij FS, Fiasconaro M, Widmar M, Wei IH, Pappou EP, Smith JJ, Nash GM, Weiser MR, Paty PB, Shahrokni A, Garcia-Aguilar J. Comparison of short-term outcomes and survival between minimally invasive colectomy and open colectomy in patients 80 years of age and older. J Robot Surg 17: 1857-1865, 2023.

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CV information above last modified September 05, 2025

Jesse Joshua Smith

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Jesse Joshua Smith

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Research Interests

Education & Training

Degree-Granting Education

Postgraduate Training

Licenses & Certifications

Experience & Service

Administrative Appointments/Responsibilities

Other Professional Positions

Institutional Committee Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Regional Presentations

National Presentations

International Presentations

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Invited Articles

Review Articles

Other Articles

Editorials

Abstracts

Book Chapters

Letters to the Editor

Patient Reviews

Request an Appointment

Related Links

Care Centers and Clinics

Departments and Divisions

Labs

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Help #EndCancer

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