Jian Hu
Department of Cancer Biology, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Felix L Haas Endowed Professor in Basic Science, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Professor, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2007 | University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, US, Biochemistry and Biophysics, Ph.D |
| 2002 | Fudan Medical School, Shanghai Cancer Center, Shanghai, CN, Molecular Biology, M.S |
| 1999 | Fudan University, Shanghai, CN, Biology, BS |
Postgraduate Training
| 2011-2014 | Instructor, UT MD Anderson Cancer Center, Houston, Texas |
| 2007-2011 | Postdoctoral Fellow, Cancer Genetics, Dana Farber Cancer Center, Harvard Medical School, Boston, Massachusetts |
Experience & Service
Administrative Appointments/Responsibilities
Scientific Director, High Resolution Electron Microscopy Facility, The University of Texas MD Anderson Cancer Center, Houston, TX, 2024 - Present
Scientific Director, Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Director, Cancer Biology Program, The University of Texas MD Anderson Cancer Center (GSBS), Houston, TX, 2022 - Present
Other Professional Positions
Course Director, Cancer Neuroscience, MD Anderson Cancer Center and UT Health Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2023 - Present
Director, Program Directors Committee,MD Anderson Cancer Center and UT Health Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2022 - Present
Course Director, Biology of Neurological Diseases, MD Anderson Cancer Center and UT Health Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2022 - Present
Chair, Teaching Academy Sub-Committee, MD Anderson Graduate and Education Committee, Houston, TX, 2021 - Present
Executive Committee Member, GSBS Executive Committee, Houston, TX, 2021 - Present
Executive Committee Member, MD Anderson Cancer Center Brain Tumor Center Member, MD Anderson Cancer Center, Houston, TX, 2018 - Present
Course Director, Basic and Translational Cancer Biology, MD Anderson Cancer Center and UT Health Houston Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2018 - Present
Director, Departmental Lab Meeting Series, Department of Cancer Biology, Department of Genomic Medicine, and Therapeutic Platform, MD Anderson Cancer Center,, Houston, 2015 - Present
Director, Departmental Seminar Series, Department of Cancer Biology, MD Anderson Cancer Center, Houston, TX, 2015 - Present
Extramural Institutional Committee Activities
Member, Faculty Recruitment Committee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Promotion and Tenure Committee, The University of Texas MD Anderson Cancer Center, 2024 - 2027
Committee Member, Bridge Fund, The University of Texas MD Anderson Cancer Center, 2020 - Present
Executive Committee Member, MD Anderson/UT Health Graduate School (GSBS), The University of Texas MD Anderson Cancer Center, 2020 - Present
Co-chair, Brain Tumor Center Distinguished Lectureship, The University of Texas MD Anderson Cancer Center, 2019 - Present
Committee Member, MD Anderson Cancer Center Brain Tumor Center Executive Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present
Honors & Awards
| 2024 | Dallas/Fort-Worth Living Legend Award for Basic Science, MD Anderson Cancer Center |
| 2023 | President's Recognition of Faculty Excellence - Education & Mentorship Advancement |
| 2022 | John P. Mc Govern Award for Outstanding Teaching, MD Anderson/UT Health Graduate School (GSBS) |
| 2021 | Commended Course Director (Cancer Biology Core Course), MD Anderson/UT Health Graduate School (GSBS) |
| 2021 | President's Recognition of Faculty Excellence - Education & Mentorship Advancement |
| 2020 - 2022 | Andrew Sabin Family Fellowship Award, Andrew Sabin Family Foundation |
| 2020 - 2022 | MD Anderson Faculty Scholar Award, MD Anderson Cancer Center |
| 2019 | Young Investigators Forum, Society of Neuro-Oncology |
| 2018 | Cancer Stem Cell Young Investigator Award, Cancer Stem Cell Conference (CSC) |
| 2018 | Young Investigator MERIT Award (R37), NCI |
| 2018 | John P. McGovern Award for Outstanding Teaching, MD Anderson UTHealth Graduate School (GSBS) |
| 2017 - 2021 | Distinguished Scientist Award, Sontag Foundation |
| 2017 | American Cancer Society Research Scholar Award, MD Anderson Cancer Center |
| 2017 | Wall of Science Award, MD Anderson Cancer Center |
| 2016 - 2018 | Sidney Kimmel Scholar Award, The Sidney Kimmel Foundation for Cancer Research |
| 2015 | Young Investigator Workshop (Brain Tumor) Travel Award, Oslo University Hospital and MD Anderson Cancer Center |
| 2015 | CCSG New Faculty Award, UT MD Anderson |
| 2014 - 2017 | Rising STARS Award, Science and Technology Acquisition and Retention Program, The University of Texas System |
| 2014 - 2015 | Broach Scholar Award, The Broach Foundation |
| 2014 | Brain Cancer SPORE Career Development Award, NCI |
| 2013 - 2018 | K99/R00 Pathway to Independence Award, NIH |
| 2013 | Travel Award on Adult Stem Cells in Aging Diseases and Cancer, V. Else Kröner-Fresenius Symposium, Eisenach, Germany |
| 2011 | 7th Annual Postdoc/Graduate Student Retreat, Best Oral Presentation Award, Dana Farber Cancer Center |
| 2008 - 2011 | Fellow Award, Leukemia and Lymphoma Society |
| 2006 | Graduate Fellow Award, Best Graduate Student Award, Lineberger Cancer Center, University of North Carolina at Chapel Hill |
| 2005 | Travel Award: Ubiquitin and Signaling, Taos, New Mexico, Keystone Symposium |
| 2004 | Best Poster Award for Chinese Scholar Association of United States, Durham, North Carolina |
| 2002 | Guanghua Scholarship, Fudan Medical School |
| 1999 | Zengshou Scholarship, Fudan University |
Grant & Contract Support
| Date: | 2024 - 2027 |
| Title: | Tackling cancer therapy-induced central nervous system deficits |
| Funding Source: | Kleberg Foundation Award |
| Role: | PI |
| Date: | 2024 - 2025 |
| Title: | Define the unique features of nervous system immunology in context of cancer and age |
| Funding Source: | Cancer Neuroscience Initiative |
| Role: | PI |
| Date: | 2024 - 2029 |
| Title: | Restore Myeloid Phagocytosis in Glioblastoma by Targeting the QKI/PPARb/RXRa Complex |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 2P50CA127001 |
| Date: | 2023 - 2028 |
| Title: | The role of membrane homeostasis of neural stem cell and glioma stem cells in neural development and gliomagenesis |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1R01NS132944 |
| Date: | 2023 - 2028 |
| Title: | Targeting Epigenetic Machinery to Overcome Myeloid Cell-Mediated Resistance to Anti-PD-1 Therapy in GBM |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R37CA279192 |
| Date: | 2023 - 2027 |
| Title: | Normalizing membrane homeostasis in microglia/macrophages of pediatric high-grade gliomas |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230154 |
| Date: | 2022 - 2027 |
| Title: | Promoting remyelination in multiple sclerosis by simultaneously modulation myelin debris clearance and myelin lipid synthesis |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1R01NS127933 |
| Date: | 2022 - 2024 |
| Title: | Restoration of Phagocytosis Function of Glioma-Associated Microglia/Macrophage by Activating QKI-PPARb-RXRa |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP220592 |
| Date: | 2022 - 2026 |
| Title: | Epigenetic regulation of alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP220360 |
| Date: | 2022 - 2027 |
| Title: | Membrane Biology of Glioma-Associated Microglia/Macrophages |
| Funding Source: | Break Through Cancer |
| Role: | PI |
| Date: | 2021 - 2026 |
| Title: | Investigating the role of dysfunctional histone H3.3 in driving early neuronal development and pediatric high-grade gliomas |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | 1R01NS119493 |
| Date: | 2021 - 2026 |
| Title: | Systematic dissection of function and mechanism of long non-coding RNAs in glioblastoma |
| Funding Source: | NIH/NINDS |
| Role: | Co-I |
| ID: | 1R01NS117668 |
Selected Publications
Peer-Reviewed Articles
- Yu, K, Basu, S, Baquer, G, Ahn, R, Gantchev, J, Jindal, S, Regan, MS, Abou-Mrad, Z, Prabhu, MC, Williams, MJ, D’Souza, AD, Malinowski, S, Hopland, K, Elhanati, Y, Stopka, SA, Stortchevoi, A, Couturier, C, He, Z, Sun, JJ, Chen, Y, Espejo, A, Chow, KH, Yerrum, S, Kao, PL, Kerrigan, BP, Norberg, L, Nielsen, D, Douville, C, Sharma, P, Giantini-Larsen, AM, Hu, J, Ayoub, G, Elharouni, D, Polk, MJ, Landivar, AM, Masud, N, Ling, AL, Triggs, D, Piranlioglu, R, Ball, A, Soni, H, Solomon, IH, Vasquez, KL, Vogelzang, J, Puduvalli, VK, Huse, J, Kim, YB, Goswami, S, Lang Jr, FF, Sharma, P. Investigative needle core biopsies support multimodal deep-data generation in glioblastoma. Nature communications 16(1), 2025. e-Pub 2025. PMID: 40295505.
- Freitas-Cortez, MA, Masrorpour, F, Jiang, H, Mahmud, I, Lu, Y, Huang, A, Duong, LK, Wang, Q, Voss, TA, Kettlun Leyton, C, Wei, B, Chan, W, Lin, H, Zhang, J, Tsouko, E, Ganjoo, S, Barsoumian, H, Riad, TS, Hu, Y, Leuschner, C, Puebla-Osorio, N, Wang, J, Hu, J, Davies, MA, Puduvalli, VK, Billon, C, Burris, TP, Lorenzi, PL, Gan, B, Welsh, J. Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins. Molecular cancer 24(1), 2025. e-Pub 2025. PMID: 39901247.
- Ling, AL, Gantchev, J, Prabhu, MC, Basu, S, Ahn, R, Holdhoff, M, Masud, N, Ball, A, Nikas, O, Villa, GR, Regan, MS, Baquer, G, Ayoub, G, Whittaker, CA, Abou-Mrad, Z, Santos, A, Couturier, C, Elharouni, D, Vogelzang, J, Yu, K, Chen, H, He, Z, Jiang, W, Lucas, CG, Sax, HE, Lang Jr, FF, Puduvalli, VK, Tabar, V, Brennan, CW, Boire, A, Holdhoff, M, Bettegowda, C, Cima, M, Solomon, IH, Yuan, Y, Tak, PP, Sharma, P, White, F, Ligon, KL, Agar, NY, Espejo, A, Sun, JJ, Chen, Y, Jindal, S, Huse, J, Goswami, S, Akdemir, KC, Hu, J, Sharma, P, Buchold, G. Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses. Science translational medicine 17(819), 2025. e-Pub 2025. PMID: 41061048.
- Huang, Z, Ren, X, Hu, J. Drosha. Genes and Development 39(11-12):677-678, 2025. e-Pub 2025. PMID: 40345854.
- Kim, KS, Habashy, KJ, Gould, A, Zhao, J, Najem, H, Amidei, C, Saganty, R, Arrieta, VA, Dmello, C, Chen, L, Zhang, DY, Castro, BA, Billingham, L, Levey, DL, Huber, O, Marques, M, Savitsky, DA, Morin, BM, Muzzio, M, Canney, M, Horbinski, C, Zhang, P, Miska, J, Padney, S, Zhang, B, Rabadan, R, Phillips, JJ, Butowski, N, Heimberger, AB, Hu, J, Stupp, R, Chand, D, Lee-Chang, C, Sonabend, AM. Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening. Neuro-oncology 26(11):2044-2060, 2024. e-Pub 2024. PMID: 39028616.
- Min, KW, Choi, KM, Mun, H, Ko, S, Lee, JW, Sagum, C, Bedford, MT, Kim, YK, Delaney, JR, Cho, JH, Dawson, TM, Dawson, VL, Twal, W, Kim, DC, Panganiban, CH, Lang, H, Zhou, X, Shin, S, Hu, J, Heise, T, Kwon, SH, Kim, D, Kim, YH, Kang, SU, Kim, K, Lewis, S, Eroglu, A, Ryu, S, Kim, D, Chang, JH, Jung, J, Yoon, JH. Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release. Journal of cell science 137(21), 2024. e-Pub 2024. PMID: 39308343.
- Kim KS, Zhang J, Arrieta VA, Dmello C, Grabis E, Habashy K, Duffy J, Zhao J, Gould A, Chen L, Hu J, Balyasnikova I, Chand D, Levey D, Canoll P, Zhao W, Sims PA, Rabadan R, Pandey S, Zhang B, Lee-Chang C, Heiland DH, Sonabend AM. MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy. bioRxiv, 2024. e-Pub 2024. PMID: 39345374.
- Najem, H, Lea, ST, Tripathi, S, Hurley, LA, Chen, CH, William, I, Sooreshjani, M, Bowie, M, Hartley, G, Dussold, C, Pacheco, S, Dmello, C, Lee-Chang, C, McCortney, K, Steffens, A, Walshon, J, Ott, M, Wei, J, Marisetty, AL, Balyasnikova, IV, Stupp, R, Lukas, RV, Hu, J, James, CD, Horbinski, C, Lesniak, MS, Ashley, DM, Priebe, W, Platanias, LC, Curran, M, Heimberger, AB. STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma. Journal of Clinical Investigation 134(12), 2024. e-Pub 2024. PMID: 38941297.
- Pan, Y, Hu, J. Hormonal basis of brain fog in cancer treatment. Journal of Experimental Medicine 221(5), 2024. e-Pub 2024. PMID: 38597926.
- Fan, H, Song, L, Fan, J, Ma, J, Li, X, Zhang, J, Hu, J, Wu, Z, Zhang, D, Wang, L. Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades. Journal of translational medicine 21(1), 2023. e-Pub 2023. PMID: 37880655.
- Fan, H, Song, L, Fan, J, Ma, J, Li, X, Zhang, J, Hu, J, Wu, Z, Zhang, D, Wang, L. Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades. Journal of translational medicine 21(1), 2023. e-Pub 2023. PMID: 37880655.
- Fan, H, Song, L, Fan, J, Ma, J, Li, X, Zhang, J, Hu, J, Wu, Z, Zhang, D, Wang, L. Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades. Journal of translational medicine 21(1), 2023. e-Pub 2023. PMID: 37880655.
- Chen, CH, Chin, R, Hartley, G, Lea, ST, Engel, BJ, Hsieh, CE, Prasad, R, Roszik, J, Shingu, T, Lizee, GA, Heimberger, AB, Millward, S, Hu, J, Hong, DS, Curran, M. Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease. Neuro-oncology 25(8):1415-1427, 2023. e-Pub 2023. PMID: 36705543.
- Zheng, C, Wei, Y, Zhang, Q, Sun, M, Wang, Y, Hou, J, Zhang, P, Lv, X, Su, D, Jiang, Y, Gumin, J, Sahni, N, Hu, B, Wang, W, Chen, X, McGrail, DJ, Zhang, C, Huang, S, Xu, H, Chen, J, Lang Jr, FF, Hu, J, Chen, Y. Multiomics analyses reveal DARS1-AS1/YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Science Advances 9(31), 2023. e-Pub 2023. PMID: 37540752.
- Zamler, D, Hu, J. Primitive Oligodendrocyte Precursor Cells Are Highly Susceptible to Gliomagenic Transformation. Cancer Research 83(6):807-808, 2023. e-Pub 2023. PMID: 36919423.
- Cata, JP, Hu, J, Feng, L, Chung, C, Woodman, SE, Meyer, LA. Association between COVID-19 and Postoperative Neurological Complications and Antipsychotic Medication Use after Cancer Surgery. Journal of Personalized Medicine 13(2), 2023. e-Pub 2023. PMID: 36836508.
- Sun, C, Ye, Y, Tan, Z, Liu, Y, Li, Y, Hu, W, Liang, K, Egranov, SD, Huang, L, Zhang, Z, Zhang, Y, Yao, J, Nguyen, TK, Zhao, Z, Wu, A, Marks, JR, Caudle, AS, Sahin, AA, Gao, J, Gammon, ST, Piwnica-Worms, D, Hu, J, Chiao, PJ, Yu, D, Hung, MC, Curran, M, Calin, GA, Ying, H, Han, L, Lin, C, Yang, L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science Advances 9(5), 2023. e-Pub 2023. PMID: 36724291.
- Cheng, Y, Shen, Z, Gao, Y, Chen, F, Xu, H, Mo, Q, Chu, X, Peng, Cl, McKenzie, T, Palacios, BE, Hu, J, Zhou, H, Long, J. Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas. Nature communications 13(1), 2022. e-Pub 2022. PMID: 35585082.
- Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight 7(12), 2022. e-Pub 2022. PMID: 35653194.
- Rao, R, Han, R, Ogurek, S, Xue, C, Wu, LN, Zhang, L, Zhang, L, Hu, J, Phoenix, T, Waggoner, SN, Lu, QR. Glioblastoma genetic drivers dictate the function of tumor-Associated macrophages/microglia and responses to CSF1R inhibition. Neuro-oncology 24(4):584-597, 2022. e-Pub 2022. PMID: 34562087.
- Aksoy Yasar FB, Shingu T, Zamler DB, Zaman MF, Chien DL, Zhang Q, Ren J, Hu J. Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma. Front Cell Dev Biol 10:931387, 2022. e-Pub 2022. PMID: 36051438.
- Sabbagh A, Beccaria K, Ling X, Marisetty A, Ott M, Caruso H, Barton E, Kong LY, Fang D, Latha K, Zhang DY, Wei J, DeGroot J, Curran MA, Rao G, Hu J, Desseaux C, Bouchoux G, Canney M, Carpentier A, Heimberger AB. Opening of the Blood-Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models. Clin Cancer Res 27(15):4325-4337, 2021. e-Pub 2021. PMID: 34031054.
- Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Mielke S, Eyrich M, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K. Targeting the alphav integrin/TGF-beta axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest 131(14), 2021. e-Pub 2021. PMID: 34138753.
- Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun 12(1):3005, 2021. e-Pub 2021. PMID: 34021134.
- Zhou X, Shin S, He C, Zhang Q, Rasband MN, Ren J, Dai C, Zorrilla-Veloz RI, Shingu T, Yuan L, Wang Y, Chen Y, Lan F, Hu J. Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. Elife 10, 2021. e-Pub 2021. PMID: 33942715.
- Ren J, Dai C, Zhou X, Barnes JA, Chen X, Wang Y, Yuan L, Shingu T, Heimberger AB, Chen Y, Hu J. Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med 218(1), 2021. e-Pub 2021. PMID: 33045062.
- Cui M, Zorrilla-Veloz RI, Hu J, Guan B, Ma X. Diagnostic Accuracy of PET for Differentiating True Glioma Progression From Post Treatment-Related Changes: A Systematic Review and Meta-Analysis. Front Neurol 12:671867, 2021. e-Pub 2021. PMID: 34093419.
- Chiang ACA, Seua AV, Singhmar P, Arroyo LD, Mahalingam R, Hu J, Kavelaars A, Heijnen CJ. Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice. Acta Neuropathol Commun 8(1):193, 2020. e-Pub 2020. PMID: 33183353.
- Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight 5(17), 2020. e-Pub 2020. PMID: 32721947.
- Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα-mediated lipid metabolism. J Clin Invest 130(5):2220-2236, 2020. e-Pub 2020. PMID: 32202512.
- Chen D, Li G, Ji C, Lu Q, Qi Y, Tang C, Xiong J, Hu J, Yasar FBA, Zhang Y, Hoon DSB, Yao Y, Zhou L. Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors. J Immunother Cancer 8(1), 2020. e-Pub 2020. PMID: 32457124.
- Li F, Deng Z, Zhang L, Wu C, Jin Y, Hwang I, Vladimirova O, Xu L, Yang L, Lu B, Dheekollu J, Li JY, Feng H, Hu J, Vakoc CR, Ying H, Paik J, Lieberman PM, Zheng H. ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. EMBO J:e96659. e-Pub 2019. PMID: 31454099.
- Yao Y, Luo F, Tang C, Chen D, Qin Z, Hua W, Xu M, Zhong P, Yu S, Chen D, Ding X, Zhang Y, Zheng X, Yang J, Qian J, Deng Y, Hoon DSB, Hu J, Chu Y, Zhou L. Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial. Cancer Immunol Immunother 67(11):1777-1788, 2018. e-Pub 2018. PMID: 30159779.
- Chen D, Chen D, Cao D, Hu J, Yao Y. A signature based on survival-related genes identifies high-risk glioblastomas harboring immunosuppressive and aggressive ECM characteristics. Zhong Nan Da Xue Xue Bao Yi Xue Ban 43(4):368-382, 2018. e-Pub 2018. PMID: 29774872.
- Hwang I, Cao D, Na Y, Kim DY, Zhang T, Yao J, Oh H, Hu J, Zheng H, Yao Y, Paik J. Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Stem Cell Reports 10(4):1208-1221, 2018. e-Pub 2018. PMID: 29606613.
- Zhang P, He D, Xu Y, Hou J, Pan BF, Wang Y, Liu T, Davis CM, Ehli EA, Tan L, Zhou F, Hu J, Yu Y, Chen X, Nguyen TM, Rosen JM, Hawke DH, Ji Z, Chen Y. Genome-wide identification and differential analysis of translational initiation. Nat Commun 8(1):1749, 2017. e-Pub 2017. PMID: 29170441.
- Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 32(1):42-56.e6, 2017. e-Pub 2017. PMID: 28697342.
- Barthel FP, Wei W, Tang M, Martinez-Ledesma E, Hu X, Amin SB, Akdemir KC, Seth S, Song X, Wang Q, Lichtenberg T, Hu J, Zhang J, Zheng S, Verhaak RG. Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet 49(3):349-357, 2017. e-Pub 2017. PMID: 28135248.
- Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev 31(4):370-382, 2017. e-Pub 2017. PMID: 28289141.
- Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RG, DePinho RA. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell 167(5):1281-1295.e18, 2016. e-Pub 2016. PMID: 27863244.
- Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. e-Pub 2016. PMID: 27841882.
- Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med 14(1):46. e-Pub 2016. PMID: 26861698.
- Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu AJ. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells International 2016(10.1155):10, 2016. e-Pub 2016.
- Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res 25(3):316-27, 2015. e-Pub 2015. PMID: 25650244.
- Yao Y, Hu J, Shen Z, Yao R, Liu S, Li Y, Cong H, Wang X, Qiu W, Yue L. MiR-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. J Cell Mol Med. e-Pub 2015. PMID: 25639535.
- Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J. Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer. J Vis Exp(98), 2015. e-Pub 2015. PMID: 25938254.
- Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 110(36):14520-7, 2013. e-Pub 2013. PMID: 23918370.
- Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 488(7411):337-42, 2012. e-Pub 2012. PMID: 22895339.
- Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev 26(13):1459-72, 2012. e-Pub 2012. PMID: 22751500.
- Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149(3):656-70, 2012. e-Pub 2012.
- Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148(5):896-907, 2012. e-Pub 2012.
- Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4):651-63, 2012. e-Pub 2012. PMID: 22341440.
- Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 2010. e-Pub 2010. PMID: 21124456.
- Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Jr KW, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-84, 2010. e-Pub 2010. PMID: 21075312.
- Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010. e-Pub 2010. PMID: 20478531.
- Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, Paik JH, Segatto O, Brennan C, Elferink LA, Wang YA, Chin L, DePinho RA. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A 107(15):6912-7, 2010. e-Pub 2010. PMID: 20351267.
- Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev 22(7):866-71, 2008. e-Pub 2008. PMID: 18381890.
- He Y, McCall CM, Hu J, Zeng Y, Xiong Y. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev 20(21):2949-54, 2006. e-Pub 2006. PMID: 17079684.
- Hu J, Xiong Y. An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem 281(7):3753-6, 2006. e-Pub 2006. PMID: 16407242.
Review Articles
- Xing, J, McKenzie, T, Hu, J. Lipid-Laden Microglia. Cells 14(16), 2025. e-Pub 2025. PMID: 40862760.
- Frank, ML, Lu, K, Erdogan, C, Han, Y, Hu, J, Wang, T, Heymach, JV, Zhang, J, Reuben, A. T-Cell Receptor Repertoire Sequencing in the Era of Cancer Immunotherapy. Clinical Cancer Research 29(6):994-1008, 2023. e-Pub 2023. PMID: 36413126.
- Barnes-Vélez, JA, Aksoy Yasar, FB, Hu, J. Myelin lipid metabolism and its role in myelination and myelin maintenance. Innovation 4(1), 2023. e-Pub 2023. PMID: 36588745.
- Güran, E, Hu, J, Wefel, JS, Chung, C, Cata, JP. Perioperative considerations in patients with chemotherapy-induced cognitive impairment. British journal of anaesthesia 129(6):909-922, 2022. e-Pub 2022. PMID: 36270848.
- Zorrilla-Veloz, RI, McKenzie, T, Palacios, BE, Hu, J. Nuclear hormone receptors in demyelinating diseases. Journal of Neuroendocrinology 34(7), 2022. e-Pub 2022. PMID: 35734821.
- Privorotskiy A, Bhavsar SP, Lang FF, Hu J, Cata JP. Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review. Neurooncol Adv 2(1):vdaa123, 2020. e-Pub 2020. PMID: 33205044.
Other Articles
- Hwang, WL, Perrault, EN, Birbrair, A, Mattson, BJ, Gutmann, DH, Mabbott, D, Cukierman, E, Repasky, EA, Sloan, EK, Zong, H, Demir, IE, Saloman, JL, Borniger, JC, Hu, J, Dietrich, J, Breunig, JJ, Çifcibaşı, K, Ahmad Kasm, KA, Valiente, M, Wintermark, M, Acharya, M, Scheff, NN, D'Silva, NJ, Vermeer, PD, Wong, RJ, Talbot, S, Hervey-Jumper, S, Wang, TC, Ye, Y, Pan, Y, Bunimovich, YL, Amit, M Integrating priorities at the intersection of cancer and neuroscience. Cancer cell 43(1):1-5, 2025. PMID: 39423816.
- Barnes-Velez JA, Pena Seneriz YL, Scott KA, Guan Y, Hu J Peroxisomal integrity in myeloid cells is required for myelin debris clearance and remyelination. J Clin Invest.
Editorials
- Hu, J. Why We Fail at Cancer Clinical Trials so Often. Anesthesiology 140(3):349-351, 2024. PMID: 38349758.
Patient Reviews
CV information above last modified July 22, 2026