Jianyin Long, Ph.D.
Department of Emergency Medicine, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1997 | Beijing Institute of Basic Medical Sciences, Beijing, CN, Biochemistry, Ph.D |
| 1994 | Beijing Institute of Basic Medical Sciences, Beijing, CN, Biochemistry, M.S |
| 1991 | Tsinghua University, Beijing, CN, Biological Sciences and Biotechnology, BS |
Postgraduate Training
| 2003-2005 | Research Associate, McGill University Health Center, Montreal |
| 1999-2003 | Postdoctoral Associate, Rutgers University, Piscataway, New Jersey |
Experience & Service
Faculty Academic Appointments
Instructor, Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2015
Assistant Professor, Division of Nephrology, Baylor College of Medicine, Houston, TX, 2011 - 2013
Instructor, Division of Nephrology, Baylor College of Medicine, Houston, TX, 2008 - 2010
Instructor, Division of General Surgery, Baylor College of Medicine, Houston, TX, 2005 - 2008
Assistant Professor, Department of Biochemistry, Beijing Institute of Basic Medical Sciences, Beijing, 1997 - 1999
Honors & Awards
| 2019 | The Internal Medicine Distinguished Paper Award in Basic Science, MDACC, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2015 - 2016 | The Internal Medicine Distinguished Paper Award in Basic Science, MDACC, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston,TX |
| 2006 | Research Presentation Award at the 2006 Molecular Surgeon Research Day, Department of Surgery, Baylor College of Medicine, Houston, TX |
| 2002 | Excellence in Research Award at the Annual CABM Retreat, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2016. The lncRNA Tug1 Interacts Directly with PGC-1[alpha] to Regulate Mitochondrial Bioenergetics in Diabetic Nephropathy. Conference. American Society of Nephrology. Chicago, IL, US.
- 2015. Identification of signature long non-coding RNAs in the development of diabetic nephropathy. Conference. American Society of Nephrology. San Diego, CA, US.
- 2012. Renal Fibrosis Is Attenuated by Targeted Disruption of miR-22. Conference. American Society of Nephrology. San Diego, CA, US.
- 2010. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor (VEGF) in hyperglycemic conditions. Invited. American Society of Nephrology. Denver, CO, US.
- 2010. MicroRNA-29c targets Sprouty1, promotes apoptosis and fibrosis, and its inhibition prevents progression of diabetic nephropathy. Invited. American Society of Nephrology. Denver, CO, US.
- 2009. Micromanaging VEGF by microRNA-93 in diabetes. Invited. American Society of Nephrology. San Diego, CA, US.
- 2008. Modulation of TGF-β signaling by Cbl adaptor proteins. Invited. Division of Nephrology, Department of Medicine, Baylor College of Medicine. Houston, TX, US.
- 2005. SIP1 sumoylation selectively attenuates E-cadherin repression. Invited. Department of Surgery, Baylor College of Medicine. Houston, TX, US.
International Presentations
- 2016. PGC1-alpha interacts directly with lncRNA Tug1 to modulate mitochondrial bioenergetics. Conference. RNA Society. Kyoto, JP.
- 2004. ZEB family proteins sumoylation and EMT. Invited. Molecular Oncology Group, McGill University. Montreal, CA.
- 2003. Regulation of TGF-β signaling by PIAS family proteins. Invited. Molecular Oncology Group, McGill University. Montreal, CA.
- 2003. Regulation of TGF-β signaling by PIAS family proteins. Invited. Samuel Lunenfeld Research Institute, University of Toronto. Toronto, CA.
Grant & Contract Support
| Date: | 2019 - 2024 |
| Title: | Role of ARF6 in the Progression of Diabetic Kidney Disease |
| Funding Source: | NIH/NIDDK |
| Role: | Co-I |
| ID: | 5K08DK119466 |
| Date: | 2011 - 2025 |
| Title: | microRNA in diabetic nephropathy |
| Funding Source: | NIH/NIDDK |
| Role: | Co-PI |
| ID: | 5R01DK091310 |
| Date: | 2009 - 2025 |
| Title: | Role of Rho kinase in diabetic nephropathy |
| Funding Source: | NIH/NIDDK |
| Role: | Co-PI |
| ID: | R01DK078900 |
| Date: | 2004 - 2010 |
| Title: | Statins and VEGF-induced cytoskeletal remodeling |
| Funding Source: | NIH/NIDDK |
| Role: | Project Leader |
| ID: | RO1DK067604 |
| Date: | 2004 - 2009 |
| Title: | Regulation of Tumor Suppressor Functions of Smad4 by Ubiquitin and Ubiquitin-like Pathways |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| ID: | R01 CA108454 |
| Date: | 2003 - 2008 |
| Title: | Functions of PIAS Proteins in the Regulation of Tumor Suppressor Smad4 |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Project Leader |
| ID: | RSG CCG-106166 |
| Date: | 2002 - 2005 |
| Title: | Signals regulating epithelial mesenchymal transition and dispersal in breast cancer |
| Funding Source: | CBCRA/NCIC |
| Role: | Project Key Personnel |
| ID: | 013267 |
| Date: | 2001 - 2006 |
| Title: | Role of Smad proteins in cell growth regulation |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| ID: | R01 CA087329 |
Selected Publications
Peer-Reviewed Articles
- Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. Publisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun 15(1):3022, 2024. e-Pub 2024. PMID: 38589378.
- Mise K, Long J, Galvan DL, Ye Z, Fan G, Sharma R, Serysheva II, Moore TI, Jeter CR, Anna Zal M, Araki M, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun 15(1):1965, 2024. e-Pub 2024. PMID: 38438382.
- Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L, Saha PK, Kanwar YS, Chang BH, Danesh FR. The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease. J Biol Chem 299(9):105185, 2023. e-Pub 2023. PMID: 37611830.
- Long J, Danesh FR. Promises and challenges of miRNA therapeutics. Am J Physiol Renal Physiol 323(6):F673-F674, 2022. e-Pub 2022. PMID: 36264885.
- Li L, Long J, Mise K, Galvan DL, Overbeek PA, Tan L, Kumar SV, Chan WK, Lorenzi PL, Chang BH, Danesh FR. PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites. Cell Rep 36(6):109510, 2021. e-Pub 2021. PMID: 34380028.
- Long J, Galvan DL, Mise K, Kanwar YS, Li L, Poungavrin N, Overbeek PA, Chang BH, Danesh FR. Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1. J Biol Chem 295(47):15840-15852, 2020. e-Pub 2020. PMID: 32467232.
- Galvan DL, Long J, Green N, Chang BH, Lin JS, Schumacker P, Truong LD, Overbeek P, Danesh FR. Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice. J Clin Invest 130:2807-2823, 2019. e-Pub 2019. PMID: 31063459.
- Long J, Danesh FR. Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy. Diabetes 67(4):552-553, 2018. e-Pub 2018. PMID: 29559513.
- Galvan DL, Badal SS, Long J, Chang BH, Schumacker PT, Overbeek PA, Danesh FR. Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy. Kidney Int 92(5):1282-1287, 2017. e-Pub 2017. PMID: 28754553.
- Liu S, Long J, Yuan B, Zheng M, Xiao M, Xu J, Lin X, Feng XH. SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-β Responses. J Biol Chem 291(47):24418-24430, 2016. e-Pub 2016. PMID: 27703003.
- Long J, Badal SS, Ye Z, Wang Y, Ayanga BA, Galvan DL, Green NH, Chang BH, Overbeek PA, Danesh FR. Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest 126(11):4205-4218, 2016. e-Pub 2016. PMID: 27760051.
- Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR. miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy. Nat Commun 7:12076, 2016. e-Pub 2016. PMID: 27350436.
- Long J, Badal SS, Wang Y, Chang BH, Rodriguez A, Danesh FR. MicroRNA-22 Is a Master Regulator of Bone Morphogenetic Protein-7/6 Homeostasis in the Kidney. J Biol Chem 288(51):36202-14, 2013. e-Pub 2013. PMID: 24163368.
- Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Chang BH, Schumacker PT, Danesh FR. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 15(2):186-200, 2012. e-Pub 2012. PMID: 22326220.
- Long J, Wang Y, Wang W, Chang BH, Danesh FR. MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem 286(13):11837-48, 2011. e-Pub 2011. PMID: 21310958.
- Long J, Wang Y, Wang W, Chang BH, Danesh FR. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem 285(30):23457-65, 2010. e-Pub 2010. PMID: 20501654.
- Wang J, Wang Y, Long J, Chang BH, Wilson MH, Overbeek P, Danesh FR. Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo. Genesis 48(7):446-51, 2010. e-Pub 2010. PMID: 20641128.
- Wang D, Long J, Dai F, Liang M, Feng XH, Lin X. BCL6 represses Smad signaling in transforming growth factor-beta resistance. Cancer Res 68(3):783-9, 2008. e-Pub 2008. PMID: 18245479.
- Wrighton KH, Willis D, Long J, Liu F, Lin X, Feng XH. Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling. J Biol Chem 281(50):38365-75, 2006. e-Pub 2006. PMID: 17035229.
- Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 125(5):915-28, 2006. e-Pub 2006. PMID: 16751101.
- Wang G, Long J, Matsuura I, He D, Liu F. The Smad3 linker region contains a transcriptional activation domain. Biochem J 386(Pt 1):29-34, 2005. e-Pub 2005. PMID: 15588252.
- Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430(6996):226-31, 2004. e-Pub 2004. PMID: 15241418.
- Long J, Wang G, He D, Liu F. Repression of Smad4 transcriptional activity by SUMO modification. Biochem J 379(Pt 1):23-9, 2004. e-Pub 2004. PMID: 14750902.
- Long J, Wang G, Matsuura I, He D, Liu F. Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). Proc Natl Acad Sci U S A 101(1):99-104, 2004. e-Pub 2004. PMID: 14691252.
- Long J, Matsuura I, He D, Wang G, Shuai K, Liu F. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc Natl Acad Sci U S A 100(17):9791-6, 2003. e-Pub 2003. PMID: 12904571.
- Denissova NG, Pouponnot C, Long J, He D, Liu F. Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc Natl Acad Sci U S A 97(12):6397-402, 2000. e-Pub 2000. PMID: 10823886.
- Long J, Wang H, Liu L, Wang F, Zhou T. Expression of human transforming growth factor beta1 in E. coli (I) : Direct expression in cytoplasm. Sci China C Life Sci 41(5):548-54, 1998. e-Pub 1998. PMID: 18726238.
- Bai YH, Wang DW, Cui XM, Long JY, Cui CB, Jia CY, Song LW. Expression of transforming growth factor beta in radiation interstitial pneumonitis. J Environ Pathol Toxicol Oncol 16(1):15-20, 1997. e-Pub 1997. PMID: 9256927.
Review Articles
- Coellar JD, Long J, Danesh FR. Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy. Nephron 145(4):404-414, 2021. e-Pub 2021. PMID: 33853077.
Other Articles
- Long J, Wang F, Liu L, Wang H, Chou TC Secretion expression of human transforming growth factor 1 in E. coli. Chinese J Biochem Mol Biol 15:179-184, 1999.
- Long J, Wang H Clinical potential and application of transforming growth factor beta. Bulletin Acad Military Med Sci 21:135-140, 1997.
- Long J, Wang H Advances in the study of peptide growth factor receptors. Prog Biochem Biophys 23:200-204, 1996.
- Long J, Zhang H, Wang H, Yu G Expression of human transforming growth factor beta1 gene in COS-7 cells. Chinese J Biochem Mol Biol 11(4):396-400, 1995.
- Long J, Wang H Structure and function of latent forms of transforming growth factor beta. Prog Biochem Biophys 21:27-31, 1994.
Abstracts
- Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L, Saha PK, Kanwar YS, Chang BH, Danesh FR. The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease. J Biol Chem 299(9):105185, 2023. e-Pub 2023. PMID: 37611830.
- Mise K, Long J, Galvan DL, Ye Z, Fan G, Serysheva II, Moore TI, Wada J, Schumacker PT, Chang BH, Danesh FR. NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease. Res Sq, 2023. e-Pub 2023. PMID: 37461606.
Patient Reviews
CV information above last modified July 22, 2026