JINGLING JIN, PhD
Department of Cell Therapy Institute, Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Lymphoma/Myeloma, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2004 | Seoul National University, Seoul, KOR, PHD, Biomedical Science |
Postgraduate Training
| 2007-2010 | Research Fellowship, Baylor College of Medicine, Houston |
| 2004-2007 | Research Fellowship, University of Nevada, Nevada |
Experience & Service
Academic Appointments
Assistant Professor, Department of Pediatric-Oncology, Hematology and Oncology, Division of Pediatrics, Baylor College of Medicine, Houston, 2014 - 2021
Assistant Professor, Department of Immunology, Baylor College of Medicine, Houston, TX, 2012 - 2014
Honors & Awards
| 2012 | Estela E. Medrano Award of Excellence in Aging Research. Baylor College of Medicine, Houston. U.S.A |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Xu X, Huang W, Heczey A, Liu D, Guo L, Wood M, Jin J, Courtney AN, Liu B, Di Pierro EJ, Hicks J, Barragan GA, Ngai H, Chen Y, Savoldo B, Dotti G, Metelitsa LS. NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma. Clin Cancer Res 25(23):7126-7138, 2019. e-Pub 2019. PMID: 31484667.
- Li H, Yu Y, Zhao Y, Wu D, Yu X, Lu J, Chen Z, Zhang H, Hu Y, Zhai Y, Su J, Aheman A, De Las Casas A, Jin J, Xu X, Shi Z, Woodfield SE, Vasudevan SA, Agarwal S, Yan Y, Yang J, Foster JH. Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling. Cancer Lett 457:129-141, 2019. e-Pub 2019. PMID: 31100410.
- Jin J, Jin J, Woodfield SE, Patel RH, Jin NG, Shi Y, Liu B, Sun W, Chen X, Yu Y, Vasudevan SA. Targeting LRH-1 in hepatoblastoma cell lines causes decreased proliferation. Oncol Rep 41(1):143-153, 2019. e-Pub 2018. PMID: 30320362.
- Zhang T, Guan G, Chen T, Jin J, Zhang L, Yao M, Qi X, Zou J, Chen J, Lu F, Chen X. Methylation of PCDH19 predicts poor prognosis of hepatocellular carcinoma. Asia Pac J Clin Oncol 14(5):e352-e358, 2018. e-Pub 2018. PMID: 29749051.
- Ngai H, Tian G, Courtney AN, Ravari SB, Guo L, Liu B, Jin J, Shen ET, Di Pierro EJ, Metelitsa LS. IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy. J Immunol 201(7):2141-2153, 2018. e-Pub 2018. PMID: 30111631.
- Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, López-Terrada D, Vasudevan SA. A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma. Sci Rep 7(1):17751, 2017. e-Pub 2017. PMID: 29259231.
- Sun W, Rojas Y, Wang H, Yu Y, Wang Y, Chen Z, Rajapakshe K, Xu X, Huang W, Agarwal S, Patel RH, Woodfield S, Zhao Y, Jin J, Zhang H, Major A, Hicks MJ, Shohet JM, Vasudevan SA, Coarfa C, Yang J, Nuchtern JG. EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma. Oncotarget 8(55):94780-94792, 2017. e-Pub 2017. PMID: 29212266.
- Lu J, Guan S, Zhao Y, Yu Y, Woodfield SE, Zhang H, Yang KL, Bieerkehazhi S, Qi L, Li X, Gu J, Xu X, Jin J, Muscal JA, Yang T, Xu GT, Yang J. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model. Cancer Lett 400:61-68, 2017. e-Pub 2017. PMID: 28455243.
- Jin J, Valanejad L, Nguyen TP, Lewis K, Wright M, Cast A, Stock L, Timchenko L, Timchenko NA. Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell Rep 16(3):744-56, 2016. e-Pub 2016. PMID: 27373160.
- Jin J, Hong IH, Lewis K, Iakova P, Breaux M, Jiang Y, Sullivan E, Jawanmardi N, Timchenko L, Timchenko NA. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. Hepatology 61(1):315-25, 2015. e-Pub 2014. PMID: 25043739.
- Hong IH, Lewis K, Iakova P, Jin J, Sullivan E, Jawanmardi N, Timchenko L, Timchenko N. Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments. J Biol Chem 289(2):1106-18, 2014. e-Pub 2013. PMID: 24273171.
- Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev 134(9):407-15, 2013. e-Pub 2013. PMID: 24007921.
- Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA. Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer. J Biol Chem 288(20):14451-14462, 2013. e-Pub 2013. PMID: 23564453.
- Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology 57(3):1098-106, 2013. e-Pub 2013. PMID: 23172628.
- Jin J, Iakova P, Breaux M, Sullivan E, Jawanmardi N, Chen D, Jiang Y, Medrano EM, Timchenko NA. Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis. Cell Rep 3(3):831-43, 2013. e-Pub 2013. PMID: 23499441.
- Jin YR, Jin JL, Li CH, Piao XX, Jin NG. Ursolic acid enhances mouse liver regeneration after partial hepatectomy. Pharm Biol 50(4):523-8, 2012. e-Pub 2011. PMID: 22136205.
- Jin J, Iakova P, Jiang Y, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology 54(3):989-98, 2011. e-Pub 2011. PMID: 21638299.
- Jin J, Wang GL, Iakova P, Shi X, Haefliger S, Finegold M, Timchenko NA. Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging Cell 9(5):895-910, 2010. PMID: 20698834.
- Wang GL, Shi X, Haefliger S, Jin J, Major A, Iakova P, Finegold M, Timchenko NA. Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. J Clin Invest 120(7):2549-62, 2010. PMID: 20516642.
- Orellana D, Liu X, Wang GL, Jin J, Iakova P, Timchenko NA. Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP. J Biol Chem 285(30):23444-56, 2010. e-Pub 2010. PMID: 20498378.
- Ro S, Park C, Jin J, Zheng H, Blair PJ, Redelman D, Ward SM, Yan W, Sanders KM. A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases. Gastroenterology 138(3):1068-78.e1-2, 2010. e-Pub 2009. PMID: 19917283.
- Jin J, Wang GL, Salisbury E, Timchenko L, Timchenko NA. GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell Cycle 8(15):2356-9, 2009. e-Pub 2009. PMID: 19571675.
- Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol 29(14):3867-80, 2009. e-Pub 2009. PMID: 19398579.
- Jin J, Wang GL, Timchenko L, Timchenko NA. GSK3beta and aging liver. Aging (Albany NY) 1(6):582-5, 2009. e-Pub 2009. PMID: 20157540.
- Kim JM, Koo YK, Jin J, Lee YY, Park S, Yun-Choi HS. Augmentation of U46619 induced human platelet aggregation by aspirin. Platelets 20(2):111-9, 2009. PMID: 19235053.
- Ro S, Park C, Song R, Nguyen D, Jin J, Sanders KM, McCarrey JR, Yan W. Cloning and expression profiling of testis-expressed piRNA-like RNAs. RNA 13(10):1693-702, 2007. e-Pub 2007. PMID: 17698640.
- Jin J, Jin N, Zheng H, Ro S, Tafolla D, Sanders KM, Yan W. Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod 77(1):37-44, 2007. e-Pub 2007. PMID: 17344468.
- Zheng H, Stratton CJ, Morozumi K, Jin J, Yanagimachi R, Yan W. Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci U S A 104(16):6852-7, 2007. e-Pub 2007. PMID: 17426145.
- Pyo MK, Kim JM, Jin JL, Chang KC, Lee DH, Yun-Choi HS. Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation. Thromb Res 120(1):81-6, 2007. e-Pub 2006. PMID: 17020781.
- Ro S, Park C, Jin J, Sanders KM, Yan W. A PCR-based method for detection and quantification of small RNAs. Biochem Biophys Res Commun 351(3):756-63, 2006. e-Pub 2006. PMID: 17084816.
- Jin JL, O'Doherty AM, Wang S, Zheng H, Sanders KM, Yan W. Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Biol Reprod 73(6):1235-42, 2005. e-Pub 2005. PMID: 16107607.
- Lee YY, Jang DS, Jin JL, Yun-Choi HS. Anti-platelet aggregating and anti-oxidative activities of 11-O-(4'-O-methylgalloyl)-bergenin, a new compound isolated from Crassula cv. 'Himaturi'. Planta Med 71(8):776-7, 2005. PMID: 16142645.
- Jin JL, Lee S, Lee YY, Kim JM, Heo JE, Yun-Choi HS. Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. Planta Med 70(6):564-6, 2004. PMID: 15241893.
- Jin JL, Lee YY, Heo JE, Lee S, Kim JM, Yun-Choi HS. Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora. Arch Pharm Res 27(4):376-80, 2004. PMID: 15180300.
- Pyo MK, Jin JL, Koo YK, Yun-Choi HS. Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects. Arch Pharm Res 27(4):381-5, 2004. PMID: 15180301.
- Lee YY, Lee S, Jin JL, Yun-Choi HS. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch Pharm Res 26(9):723-6, 2003. PMID: 14560920.
Patient Reviews
CV information above last modified January 19, 2022