Jinsheng Weng, M.D., Ph.D.
Department of Lymphoma-Myeloma - Research, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Lymphoma/Myeloma - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2007 | Texas A&M System University Health Science Center, Houston, TX, USA, PHD, Medical Sciences |
| 2002 | Sun Yat-sen University of Medical Sciences, Guangzhou, CHN, MS, Internal Medicine |
| 1994 | Jiang Xi Medical College, Nanchang, CHN, MD, Preventive Medicine |
Experience & Service
Academic Appointments
Instructor, Department of Lymphoma/Myeloma - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2018
Honors & Awards
| 2014 | Early Career Faculty Travel Grant, American Association of Immunologists |
Selected Publications
Peer-Reviewed Articles
- Weng J, Baio FE, Moriarty KE, Torikai H, Wang H, Liu Z, Maiti SN, Gwak D, Popescu MS, Cha SC, Cooper LJ, Neelapu SS, Kwak LW. Targeting B-cell malignancies through human B-cell receptor specific CD4 T cells. Oncoimmunology 5(11):e1232220, 2016. e-Pub 2016. PMID: 27999743.
- Weng J, Moriarty KE, Baio FE, Chu F, Kim SD, He J, Jie Z, Xie X, Ma W, Qian J, Zhang L, Yang J, Yi Q, Neelapu SS, Kwak LW. IL-15 enhances the anti-tumor effect of human antigen-specific CD8 T cells by cellular senescence delay. Oncoimmunology 5(12):e1237327, 2016. e-Pub 2016. PMID: 28123872.
- Rodriguez M, Luo W, Weng J, Zeng L, Yi Z, Siwko S, Liu M. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB. Oncogenesis 3:e114, 2014. e-Pub 2014. PMID: 25111863.
- Voo KS, Bover L, Harline ML, Weng J, Sugimoto N, Liu YJ. Targeting of TLRs inhibits CD4+ regulatory T cell function and activates lymphocytes in human peripheral blood mononuclear cells. J Immunol 193(2):627-34, 2014. e-Pub 2014. PMID: 24928999.
- Yi T, Weng J, Siwko S, Luo J, Li D, Liu M. LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. J Biol Chem 289(13):8767-80, 2014. e-Pub 2014. PMID: 24519938.
- Baio FE, Kwak LW, Weng J. Towards an off-the-shelf vaccine therapy targeting shared B-cell tumor idiotypes. Am J Blood Res 4(2):46-52, 2014. e-Pub 2014. PMID: 25755905.
- Siwko S, Lai L, Weng J, Liu M. Lgr4 in ocular development and glaucoma. J Ophthalmol 2013:987494, 2013. e-Pub 2013. PMID: 23840940.
- Weng J, Rawal S, Chu F, Park HJ, Sharma R, Delgado DA, Fayad L, Fanale M, Romaguera J, Luong A, Kwak LW, Neelapu SS. TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas. Blood 120(8):1613-23, 2012. e-Pub 2012. PMID: 22645177.
- Matsueda S, Wang M, Weng J, Li Y, Yin B, Zou J, Li Q, Zhao W, Peng W, Legras X, Loo C, Wang RF, Wang HY. Identification of prostate-specific G-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapy. PLoS One 7(9):e45756, 2012. e-Pub 2012. PMID: 23029225.
- Weng J, Cha SC, Matsueda S, Alatrash G, Popescu MS, Yi Q, Molldrem JJ, Wang M, Neelapu SS, Kwak LW. Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytes. Clin Cancer Res 17(18):5945-52, 2011. e-Pub 2011. PMID: 21813633.
- Luo J, Zhou W, Zhou X, Li D, Weng J, Yi Z, Cho SG, Li C, Yi T, Wu X, Li XY, de Crombrugghe B, Höök M, Liu M. Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development 136(16):2747-56, 2009. e-Pub 2009. PMID: 19605502.
- Song H, Luo J, Luo W, Weng J, Wang Z, Li B, Li D, Liu M. Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem 283(52):36687-97, 2008. e-Pub 2008. PMID: 18955481.
- Jin C, Yin F, Lin M, Li H, Wang Z, Weng J, Liu M, Da Dong X, Qu J, Tu L. GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development. Invest Ophthalmol Vis Sci 49(10):4245-53, 2008. e-Pub 2008. PMID: 18487371.
- Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M. Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A 105(16):6081-6, 2008. e-Pub 2008. PMID: 18424556.
- Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Prostate 66(8):847-57, 2006. e-Pub 2006. PMID: 16491480.
- Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M. PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. Int J Cancer 118(6):1471-80, 2006. e-Pub 2006. PMID: 16206286.
- Mitchell DC, Abdelrahim M, Weng J, Stafford LJ, Safe S, Bar-Eli M, Liu M. Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. J Biol Chem 281(1):51-8, 2006. e-Pub 2005. PMID: 16260418.
- Weng J, Ma W, Mitchell D, Zhang J, Liu M. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. J Cell Biochem 96(5):1034-48, 2005. e-Pub 2005. PMID: 16149059.
- Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M. Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Int J Cancer 113(5):811-8, 2005. e-Pub 2005. PMID: 15499628.
Grant & Contract Support
| Title: | Develop of human tumor antigen specific T cells against Multiple Myeloma |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Development of Human Tumor Antigen Specific T cells against Multiple Myeloma |
| Funding Source: | International Myeloma Foundation |
| Role: | Principal Investigator |
| Title: | Targetting CLL through human tumor antigen & specific T cells |
| Funding Source: | Lady Leukemia League |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified January 12, 2023