Jinsong Liu, M.D., MA, Ph.D.
Department of Pathology, Division of Pathology/Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Professor with Tenure, Department of Pathology/Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1990 | Case Western Reserve University, Cleveland, OH, USA, PHD, Biochemistry |
| 1987 | Indiana University, Bloomington, IN, USA, MA, Biology |
| 1983 | Shanghai Medical University, Shanghai, CHN, MD, Medicine |
Postgraduate Training
| 1998-1999 | Fellow in Surgical Pathology, New York University Medical Center, New York, NY |
| 1994-1999 | Resident in Pathology, New York University Medical Center, New York, NY |
| 1991-1993 | Post-doctoral Fellow, Howard Hughes Medical Inst, Bio.Chemistry & Internal Med The University of Michigan Medical Center, Ann Arbor, MI |
Honors & Awards
| 2004 | American's Top Physician, "Guide to America's Top Physician", Consumer's Research Council of America |
| 2001 | Incentive Salary Awards, The University of Texas M. D. Anderson Cancer Center |
Selected Publications
Peer-Reviewed Articles
- Zhang S, Lu Z, Mao W, Ahmed AA, Yang H, Zhou J, Jennings N, Rodriguez-Aguayo C, Lopez-Berestein G, Miranda R, Qiao W, Baladandayuthapani V, Li Z, Sood AK, Liu J, Le XF, Bast RC. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PLoS One 10(7):e0131833, 2015. e-Pub 2015. PMID: 26146988.
- Caruso JA, Karakas C, Zhang J, Yi M, Albarracin C, Sahin A, Bondy M, Liu J, Hunt KK, Keyomarsi K. Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Breast Cancer Res 17(1):87, 2015. e-Pub 2015. PMID: 26108797.
- Sun Y, Hu L, Zheng H, Bagnoli M, Guo Y, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Ji P, Chen K, Sood AK, Mezzanzanica D, Liu J, Sun B, Zhang W. MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer. J Pathol 235(1):25-36, 2015. e-Pub 2014. PMID: 25230372.
- Dong R, Liu X, Zhang Q, Jiang Z, Li Y, Wei Y, Li Y, Yang Q, Liu J, Wei JJ, Shao C, Liu Z, Kong B. miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma. Oncotarget 5(21):10816-29, 2014. PMID: 25333261.
- Hu W, Liu T, Ivan C, Sun Y, Huang J, Mangala LS, Miyake T, Dalton HJ, Pradeep S, Rupaimoole R, Previs RA, Han HD, Bottsford-Miller J, Zand B, Kang Y, Pecot CV, Nick AM, Wu SY, Lee JS, Sehgal V, Ram P, Liu J, Tucker SL, Lopez-Berestein G, Baggerly KA, Coleman RL, Sood AK. Notch3 pathway alterations in ovarian cancer. Cancer Res 74(12):3282-93, 2014. e-Pub 2014. PMID: 24743243.
- Wen Y, Zand B, Ozpolat B, Szczepanski MJ, Lu C, Yuca E, Carroll AR, Alpay N, Bartholomeusz C, Tekedereli I, Kang Y, Rupaimoole R, Pecot CV, Dalton HJ, Hernandez A, Lokshin A, Lutgendorf SK, Liu J, Hittelman WN, Chen WY, Lopez-Berestein G, Szajnik M, Ueno NT, Coleman RL, Sood AK. Antagonism of tumoral prolactin receptor promotes autophagy-related cell death. Cell Rep 7(2):488-500, 2014. e-Pub 2014. PMID: 24703838.
- Zhang S, Mercado-Uribe I, Liu J. Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel. Int J Cancer 134(3):508-18, 2014. e-Pub 2013. PMID: 23754740.
- Zhang S, Mercado-Uribe I, Xing Z, Sun B, Kuang J, Liu J. Generation of cancer stem-like cells through the formation of polyploid giant cancer cells. Oncogene 33(1):116-28, 2014. e-Pub 2013. PMID: 23524583.
- Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun 5:5092, 2014. e-Pub 2014. PMID: 25277212.
- Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nat Commun 5:3459, 2014. e-Pub 2014. PMID: 24619206.
- Zhang S, Mercado-Uribe I, Hanash S, Liu J. iTRAQ-based proteomic analysis of polyploid giant cancer cells and budding progeny cells reveals several distinct pathways for ovarian cancer development. PLoS One 8(11):e80120, 2013. e-Pub 2013. PMID: 24348907.
- Huang J, Zhang J, Li H, Lu Z, Shan W, Mercado-Uribe I, Liu J. VCAM1 expression correlated with tumorigenesis and poor prognosis in high grade serous ovarian cancer. Am J Transl Res 5(3):336-46, 2013. e-Pub 2013. PMID: 23634244.
- Haria D, Trinh BQ, Ko SY, Barengo N, Liu J, Naora H. The Homeoprotein DLX4 Stimulates NF-κB Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer. Am J Pathol. e-Pub 2015. PMID: 26067154.
Grant & Contract Support
| Title: | Project 1, Early detection of human ovarian cancer. Specialized Program in Research Excellence (SPORE) in Ovarian Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Tissue Pathology Core. Specialized Program in Research Excellence (SPORE) in Ovarian Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Ras signaling, senescent fibroblasts, and ovarian cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | Subcontract to M.D. Anderson Cancer Center. Program Project |
| Role: | Principal Investigator |
| Title: | Role of BRCA1 and telemerase activation in the progession of breast cancer and clinical application |
| Funding Source: | Department of Defense (DOD) |
| Role: | Sponser and Mentor |
| Title: | Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Tissue Pathology Core, Specialized Program in Research Excellence (SPORE) in Ovarian Cancer (PC-C2), Tissue Pathology Core |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center |
| Role: | Co-Principal Investigator |
| Title: | Center for Systems Analysis of the Cancer Regulome |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Tissue Pathology Core, Personalized Enhancement of Primary Ovarian Cancer Chemotherapy |
| Funding Source: | Cancer Prevention and Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Multifuctional roles of homeobox gene D LX4 in ovarian cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Role of Hox Gene in Ovarian Neoplasia |
| Funding Source: | NIH/NIC |
| Role: | Co-Investigator |
| Title: | AHRI (DIRAS3) In Autophagy and Dormancy of Ovarian Cancer |
| Funding Source: | NIH/NIC |
| Role: | Co-Investigator |
| Title: | Mechanisms and targeting strategies for SWI/SNF mutations in cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Early Detection of Ovarian Cancer with Tumor Associated Proteins and Autoantibodies |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Establishment and Clinical of Ovarian patient-Derived Xenografts |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center Moonshot |
| Role: | Principal Investigator |
| Title: | Evaluate the effects of Durvalumab and Pembrolizumab in combination with chemotherapy |
| Funding Source: | UTMDACC Moonshot (CCCT) (IMT) |
| Role: | Principal Investigator |
| Title: | Immune profile changes in Ovarian Cancer Associated with Estrogen Dominance |
| Funding Source: | UTMDACC IRG |
| Role: | Principal Investigator |