Joseph A Ludwig, MD
Department of Sarcoma Medical Oncology, Division of Cancer Medicine
About Dr. Ludwig
Dr. Joseph Ludwig is a physician-scientist who specializes in the study and care of Ewing’s and other bone and soft-tissue sarcomas. He received his medical degree from the University of Iowa, completed residency and research fellowship at Mayo Clinic, and medical oncology fellowship at the National Institutes of Health. Ludwig has been a member of the MD Anderson faculty since 2006. His research program, which encompasses both basic and translational endpoints, seeks to understand how the tumor microenvironment regulates the spatial organization, phenotype, and differentiation state of cancer. Ludwig’s major focus is determine how these parameters impact the sensitivity of bone and soft-tissue sarcomas to targeted therapy in an effort to improve response rates in these patients.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | University of Iowa College of Medicine, Iowa City, IA, USA, MD, Doctor of Medicine |
| 1994 | University of Iowa College of Business, Iowa City, IA, USA, BBA, Business Administration |
Board Certifications
| 2005 | American Board of Internal Medicine-Medical Oncology |
| 2001 | American Board of Internal Medicine |
Selected Publications
Peer-Reviewed Articles
- Puerto-Camacho P, Amaral AT, Lamhamedi-Cherradi SE, Menegaz BA, Castillo-Ecija H, Ordóñez JL, Domínguez S, Jordan-Perez C, Diaz-Martin J, Romero-Pérez L, Lopez-Alvarez M, Civantos-Jubera G, Robles-Frías MJ, Biscuola M, Ferrer C, Mora J, Cuglievan B, Schadler K, Seifert O, Kontermann R, Pfizenmaier K, Simón L, Fabre M, Carcaboso ÁM, Ludwig JA, de Álava E. Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma. Clin Cancer Res 25(7):2228-2240, 2019. e-Pub 2018. PMID: 30420447.
- Ludwig, J. Flow Perfusion Effects on Three-Dimensional Culture and Drug Sensitivity of Ewring Sarcoma. PNAS 112(33), 2015. e-Pub 2015. PMID: 26240353.
- Ludwig, J. An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing’s Sarcoma. Molecular Cancer Therapeutics 10, 2015. e-Pub 2015. PMID: 25964201.
- Lamhamedi-Cherradi SE, Santoro M, Ramammoorthy V, Menegaz BA, Bartholomeusz G, Iles LR, Amin HM, Livingston JA, Mikos AG, Ludwig JA. 3D tissue-engineered model of Ewing's sarcoma. Adv Drug Deliv Rev 79-80C:155-171, 2014. e-Pub 2014. PMID: 25109853.
- Satelli A, Mitra A, Cutrera JJ, Devarie M, Xia X, Ingram DR, Dibra D, Somaiah N, Torres KE, Ravi V, Ludwig JA, Kleinerman ES, Li S. Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells. Cancer Res 74(6):1645-50, 2014. e-Pub 2014. PMID: 24448245.
- Hayes-Jordan A, Green HL, Lin H, Owusu-Agyemang P, Fitzgerald N, Arunkumar R, Mejia R, Okhuysen-Cawley R, Mauricio R, Fournier K, Ludwig J, Anderson P. Complete Cytoreduction and HIPEC Improves Survival in Desmoplastic Small Round Cell Tumor. Ann Surg Oncol 21(1):220-4, 2014. e-Pub 2013. PMID: 24046124.
- Jiang Y, Subbiah V, Janku F, Ludwig JA, Naing A, Benjamin RS, Brown RE, Anderson P, Kurzrock R. Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors. PLoS One 9(8):e93676, 2014. e-Pub 2014. PMID: 25119929.
- Schwartz GK, Tap WD, Qin LX, Livingston MB, Undevia SD, Chmielowski B, Agulnik M, Schuetze SM, Reed DR, Okuno SH, Ludwig JA, Keedy V, Rietschel P, Kraft AS, Adkins D, Van Tine BA, Brockstein B, Yim V, Bitas C, Abdullah A, Antonescu CR, Condy M, Dickson MA, Vasudeva SD, Ho AL, Doyle LA, Chen HX, Maki RG. Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol 14(4):371-82, 2013. e-Pub 2013. PMID: 23477833.
- Fong EL, Lamhamedi-Cherradi SE, Burdett E, Ramamoorthy V, Lazar AJ, Kasper FK, Farach-Carson MC, Vishwamitra D, Demicco EG, Menegaz BA, Amin HM, Mikos AG, Ludwig JA. Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A 110(16):6500-5, 2013. e-Pub 2013. PMID: 23576741.
- Subbiah V, Anderson PM, Kairemo K, Hess KR, Huh WW, Ravi V, Daw NC, Somaiah N, Ludwig JA, Benjamin RS, Chawla SP, Hong DS, Meric-Bernstam F, Ravizzini G, Kleinerman ES, Macapinlac HA, Rohren EM. Alpha particle Radium 223 dichloride in high-risk osteosarcoma: a phase I dose escalation trial. Clin Cancer Res. e-Pub 2019. PMID: 30733229.
- Jiang Y, Ludwig J, Janku F. Targeted therapies for advanced Ewing sarcoma family of tumors. Cancer Treat Rev. e-Pub 2015. PMID: 25869102.
- Pan HY, Morani A, Wang WL, Hess KR, Paulino AC, Ludwig JA, Lin PP, Daw NC, Mahajan A. Prognostic Factors and Patterns of Relapse in Ewing Sarcoma Patients Treated With Chemotherapy and R0 Resection. Int J Radiat Oncol Biol Phys. e-Pub 2015. PMID: 25772182.
Abstracts
- Heinrich Kovar, James Amatruda, Erika Brunet, Stefan Burdach, Florencia Cidre-Aranaz, Enriquew de Alava, Uta Dirksen, Wietske Van der Ent, Patirck Grohar, Thomas G.P. Grunewald, Lee Helman, Peter Houghton, Kristiina Iljin, Eberhard Korsching, Marc Ladanyi, Elizabeth Lawlor, Stephen Lessnick, Joseph Ludwig, Paul Meltzer, Markus Metzler, Jaume Mora, Richard Moriggl, Takuro Nakamura, Therodore Papamarkou, Branka Radic Sarikas, Francoise Redini, Guenther H. S. Richter, Claudia Rossig, Keri Schadler, Beat W. Schafer, Katia Scotlandi, Nathan C. Sheffield, Anang Shelat, Ewa Snaar-JagalskaPoul Sorenson, Kimberly Stegmaier, Elizabeth Stewart, Alejandro Sweet-Cordero, Karoly Szuhai, Oscar M. Tirado, Franck Tirode, Jeffrey Toretsky, Kalliopi Tsafou, Aykut Uren, Andrei Zinovyev and Olivier Delattre. The Second European interdisciplinary Ewing sarcoma research summit - A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget, 2016.
Book Chapters
- Ludwig, JA. Ewing's Sarcoma Family of Tumors. In: Bone Cancer: Progression & Therapeutic Approaches, 2nd Edition. Academic Press: San Diego, CA, 2015.