Joya Chandra, Ph.D.
Department of Pediatrics, Division of Pediatrics
About Dr. Chandra
Research in the Chandra lab is directed towards understanding the oxidative environment of cancer cells and then using this knowledge to develop therapeutic strategies that will eliminate cancer cells.
One feature common to numerous cancer cell types is alterations in the intracellular oxidative environment. The oxidative environment is constantly negotiated and represents a balance between the level of ROS (reactive oxygen species) and the antioxidant systems that disarm or inactivate ROS. Since ROS are generated as a result of cellular respiration or other normal metabolic processes, intricate networks of antioxidant enzymes are in place and are carefully regulated.
ROS are versatile in influencing cell outcome. While high doses of ROS cause cell death, low to intermediate levels can urge cells to grow. Our lab is exploring both of these endpoints. Model systems studied in the lab include leukemias (the most common pediatric cancer) and brain tumors (the deadliest pediatric malignancy). One of the leukemia model systems we study are Philadelphia chromosome positive leukemias. The Philadelphia chromosome is another name for the translocation that yields a fusion gene called BCR/ABL. The protein product of BCR/ABL is a kinase and in the past decade giant strides in improving patient outcome for Philadelphia positive leukemia patients have been made by better understanding and molecularly targeting the BCR/ABL kinase. Our lab is specifically interested in BCR/ABL’s ability to alter the oxidative environment of cells. We are working to understand how that happens and the consequences of this alteration, particularly in terms of cell signaling.
Recent years have seen the development of a body of clinically relevant biologically targeted agents including proteasome inhibitors, histone deacetylase inhibitors, and various kinase inhibitors. Many of these drugs are currently being tested in the clinic or are being used in patients with hematological malignancies. The mechanism of action of some of these drugs is attributable in part to raising ROS levels in the cell. Examples are adaphostin (a kinase inhibitor), NPI-0052 (a proteasome inhibitor), SNDX-275 and PCI-24781 (HDAC inhibitors). We are studying the source and consequences of ROS generation by these agents and will use these compounds as tools with which to better understand the biology of pediatric leukemias. We are also addressing the preclinical efficacy of these agents in leukemia model systems using primary specimens from patients and animal models.
Present Title & Affiliation
Primary Appointment
Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | University of Texas Graduate School of Biomedical Sciences and M.D. Anderson Cancer Center, Houston, TX, USA, PhD, Cancer Biology and Immunology |
| 1993 | Louisiana State University, Baton Rouge, LA, USA, BS, Major: Microbiology, Minors: English and Spanish |
Postgraduate Training
| 2000-2002 | Postdoctoral Fellowship, Drug development, Apoptosis, Leukemia Therapy, Division of Oncology Research, Mayo Clinic, Rochester, MN |
| 1998-2000 | Postdoctoral Fellowship, Apoptosis, Oxidative stress, Division of Toxicology, Institute for Environmental Medicine, Karolinska Institute, Stockholm |
Honors & Awards
| 2020 | “Kenneth Shine” Academy for Health Science Education, The University of Texas System |
| 2019 | Academy for Health Science Education, The University of Texas MD Anderson |
| 2017 | President's Recognition for Faculty Excellence |
| 2017 | President’s Recognition for Faculty Excellence in Education and Mentorship Advancement, The University of Texas MD Anderson |
| 2016 | Regents' Outstanding Teaching Award, The University of Texas MD Anderson Cancer Center |
| 2016 | Experimental Therapeutics Academic Program, Faculty Choice Award |
| 2016 | Highest Commendation for Service to the UTHSC GSBS, UTHSC Graduate School of Biomedical Sciences |
| 2016 | University of Texas System Regents Oustanding Teaching Award, University of Texas |
| 2015 | President's Recognition for Faculty Excellence |
| 2014 | Texas Business Women’s Award |
| 2014 | Faculty Leadership Academy |
| 2013 | Faculty Educator of the Month (April), The University of Texas MD Anderson Cancer Center |
| 2012 | John P. McGovern Outstanding Teacher Award, GSBS Graduate Student Association |
| 2009 | Faculty Educator of the Month (May), The University of Texas MD Anderson Cancer Center |
| 2004 | Leukemia SPORE Career Development Award |
| 2004 | Texas Federation of Business and Professional Women's Club Award |
| 2003 | Children's Oncology Group Young Investigator Award |
| 2003 | The University of Texas MD Anderson Cancer Center Institutional Research Grant |
| 2001 | NIH NRSA Individual (F32) Training Grant |
| 2001 | AACR-AFLAC Scholar-in-Training Award |
| 2000 | Wenner-Gren Foundation Fellowship for Visiting Scientists |
| 2000 | NIH NRSA Institutional (T32) Training Grant |
| 1999 | Karolinska Institute Fellowship for Visiting Scientists |
| 1999 | Travel Scholarship for Seventh European Conference on Apoptosis |
| 1997 | Special Commendation Award, University of Texas Graduate School of Biomedical Sciences |
| 1997 | American Legion Auxiliary Fellowship |
| 1997 | Andrew Sowell-Wade Huggins Endowed Scholarship |
| 1997 | Texas Regional Immunology Conference James W. McLaughlin Oral Award |
| 1997 | M.D. Anderson Associates Travel Award |
| 1997 | AACR-AFLAC Young Investigator Award |
| 1996 | John P. McGovern Award, University of Texas Graduate School of Biomedical Sciences |
| 1996 | Rhone-Poulenc Rorer Travel Award from American Association for Cancer Research (AACR) |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Garcia MB, Schadler KL, Chandra J, Clinton SK, Courneya KS, Cruz-Monserrate Z, Daniel CR, Dannenberg AJ, Demark-Wahnefried W, Dewhirst MW, Fabian CJ, Hursting SD, Irwin ML, Iyengar NM, McQuade JL, Schmitz KH, Basen-Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer. CA Cancer J Clin. e-Pub 2023. PMID: 36825928.
- Raber M, Costigan M, Chandra J, Basen-Engquist K. Cooking After Cancer: the Structure and Implementation of a Community-Based Cooking Program for Cancer Survivors. J Cancer Educ 37(3):539-545, 2022. PMID: 32754833.
- Wooten SV, Roth M, Livingston JA, Hildebrandt MAT, Chandra J, Amini B, Kleinerman ES, Gilchrist SC. Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients. J Adolesc Young Adult Oncol 11(3):320-322, 2022. e-Pub 2021. PMID: 34388045.
- Wang F, Chandra J, Kleinerman ES. Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity. Cancer Med 10(21):7572-7584, 2021. e-Pub 2021. PMID: 34523825.
- Bailey CP, Wang R, Figueroa M, Zhang S, Wang L, Chandra J. Computational immune infiltration analysis of pediatric high-grade gliomas (pHGGs) reveals differences in immunosuppression and prognosis by tumor location. Comput Syst Oncol 1(3), 2021. e-Pub 2021. PMID: 34723252.
- Wartenberg L, Raber M, Chandra J. Unique Features of a Web-Based Nutrition Website for Childhood Cancer Populations: Descriptive Study. J Med Internet Res 23(9):e24515, 2021. e-Pub 2021. PMID: 34515643.
- Shaik S, Maegawa S, Haltom AR, Wang F, Xiao X, Dobson T, Sharma A, Yang Y, Swaminathan J, Kundra V, Li XN, Schadler K, Harmanci A, Xu L, Gopalakrishnan V. REST promotes ETS1-dependent vascular growth in medulloblastoma. Mol Oncol 15(5):1486-1506, 2021. e-Pub 2021. PMID: 33469989.
- Gong S, Maegawa S, Yang Y, Gopalakrishnan V, Zheng G, Cheng D. Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6. Biochem J. e-Pub 2020. PMID: 33245113.
- Morales-Mantilla DE, Huang X, Erice P, Porter P, Zhang Y, Figueroa M, Chandra J, King KY, Kheradmand F, Rodríguez A. Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System. J Vis Exp(164), 2020. e-Pub 2020. PMID: 33165327.
- Swartz MC, Teague AK, Wells SJ, Honey T, Fu M, Mahadeo KM, Kabiri LS, Chandra J, Moody K, Schadler K. Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer. J Clin Med 9(9), 2020. e-Pub 2020. PMID: 32899945.
- Khatua S, Cooper LJN, Sandberg DI, Ketonen L, Johnson JM, Rytting ME, Liu DD, Meador H, Trikha P, Nakkula RJ, Behbehani GK, Ragoonanan D, Gupta S, Kotrotsou A, Idris T, Shpall EJ, Rezvani K, Colen R, Zaky W, Lee DA, Gopalakrishnan V. Phase I study of intraventricular infusions of autologous ex vivo expanded NK cells in children with recurrent medulloblastoma and ependymoma. Neuro Oncol 22(8):1214-1225, 2020. PMID: 32152626.
- Sun Y, Bailey CP, Sadighi Z, Zaky W, Chandra J. Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. J Neurooncol, 2020. PMID: 32504402.
- Raber M, Baranowski T, Crawford K, Sharma SV, Schick V, Markham C, Jia W, Sun M, Steinman E, Chandra J. The Healthy Cooking Index: Nutrition Optimizing Home Food Preparation Practices across Multiple Data Collection Methods. J Acad Nutr Diet, 2020. PMID: 32280056.
- Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Wakefield CE, Chandra J. Meal planning values impacted by the cancer experience in families with school-aged survivors-a qualitative exploration and recommendations for intervention development. Support Care Cancer 28(3):1305-1313, 2020. PMID: 31243584.
- Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J. Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG). Neuro Oncol, 2020. PMID: 32166329.
- Murphy BR, Raber MP, Crawford KD, Grasse L, Wartenberg L, Wu J, Dibaj SS, Chandra J. High Rates of Obesity at Presentation Persist into Survivorship across Childhood Cancer Types. Child Obes, 2020. PMID: 32176517.
- Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Chandra J. Exploring food preparation practices in families with and without school-aged childhood cancer survivors. Public Health Nutr 23(3):410-415, 2020. PMID: 31538553.
- Raber M, Basen-Engquist K, Moran NE, Chandra J. The Healthy Cooking Index does not Predict the Carotenoid Content of Home-Cooked Meals. Nutrients 12(2), 2020. PMID: 32092844.
- Harmanci A, Harmanci AS, Swaminathan J, Gopalakrishnan V. EpiSAFARI: sensitive detection of valleys in epigenetic signals for enhancing annotations of functional elements. Bioinformatics 36(4):1014-1021, 2020. PMID: 31501853.
- Cohen J, Collins L, Gregerson L, Chandra J, Cohn RJ. Nutritional concerns of survivors of childhood cancer: A "First World" perspective. Pediatr Blood Cancer:e28193, 2020. PMID: 31994836.
- Bailey CP, Figueroa M, Gangadharan A, Lee DA, Chandra J. Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol 11:2196, 2020. PMID: 33042135.
- Raber M, Wu J, Donnella H, Knouse P, Pise M, Munsell M, Liu D, Chandra J. Cellular Oxidative Stress in Pediatric Leukemia and Lymphoma Patients Undergoing Treatment Is Associated with Protein Consumption. Nutrients 12(1), 2019. PMID: 31892127.
- Kannan S, Aitken MJL, Herbrich SM, Golfman LS, Hall MG, Mak DH, Burks JK, Song G, Konopleva M, Mullighan CG, Chandra J, Zweidler-McKay PA. Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther 18(9):1615-1627, 2019. PMID: 31227645.
- Bailey CP, Figueroa M, Mohiuddin S, Zaky W, Chandra J. Cutting Edge Therapeutic Insights Derived from Molecular Biology of Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG). Bioengineering (Basel) 5(4), 2018. PMID: 30340362.
- Herbrich SM, Kannan S, Nolo RM, Hornbaker M, Chandra J, Zweidler-McKay PA. Characterization of TRKA signaling in acute myeloid leukemia. Oncotarget 9(53):30092-30105, 2018. PMID: 30046390.
- Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing. J Natl Compr Canc Netw 16(6):683-691, 2018. PMID: 29891519.
- Wang F, Iskra B, Kleinerman E, Alvarez-Florez C, Andrews T, Shaw A, Chandra J, Schadler K, Aune GJ. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity. J Pediatr Hematol Oncol 40(3):208-215, 2018. PMID: 29557918.
- Raber M, Huynh TN, Crawford K, Kim S, Chandra J. Development and Feasibility of a Community-Based, Culturally Flexible Colorectal Cancer Prevention Program. J Community Health, 2018. PMID: 29532214.
- Rivera-Del Valle N, Cheng T, Irwin ME, Donnella H, Singh MM, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol 81(3):483-495, 2018. PMID: 29313067.
- Schadler KL, Kleinerman ES, Chandra J. Diet and exercise interventions for pediatric cancer patients during therapy: tipping the scales for better outcomes. Pediatr Res 83(1-1):50-56, 2018. PMID: 29068433.
- Zaky W, Manton C, Miller CP, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer Metastasis Rev 36(4):617-633, 2017. PMID: 29071526.
- Raber M, Crawford K, Chandra J. Healthy cooking classes at a children's cancer hospital and patient/survivor summer camps: initial reactions and feasibility. Public Health Nutr:1-7, 2017. PMID: 28463101.
- Raber M, Chandra J, Upadhyaya M, Schick V, Strong LL, Durand C, Sharma S. An evidence-based conceptual framework of healthy cooking. Prev Med Rep 4:23-8, 2016. PMID: 27413657.
- Li R, Donnella H, Knouse P, Raber M, Crawford K, Swartz MC, Wu J, Liu D, Chandra J. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatr Blood Cancer, 2016. PMID: 27615542.
- Raber M, Swartz MC, Maria DS, O'Connor T, Baranowski T, Li R, Chandra J. Parental involvement in exercise and diet interventions for childhood cancer survivors: A systematic review. Pediatr Res, 2016. e-Pub 2016. PMID: 27064243.
- Swartz MC, Basen-Engquist KM, Markham C, Lyons EJ, Cox M, Chandra J, Ater JL, Askins MA, Scheurer ME, Lupo PJ, Hill R, Murray J, Chan W, Swank PR. Psychometric Analysis of the Three-Factor Eating Questionnaire-R18V2 in Adolescent and Young Adult-Aged Central Nervous System Tumor Survivors. J Adolesc Young Adult Oncol, 2016. PMID: 27042872.
- Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep 6:18953, 2016. PMID: 26804704.
- Luan J, Chu Z, Chandra J, Zhang P. Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer. Curr Protein Pept Sci, 2016. PMID: 26796303.
- Irwin M, Johnson B, Manshouri R, Amin H, Chandra J. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI resistant malignancies. Oncotarget 6(27):23631-46, 2015. PMID: 26136341.
- Li R, Raber M, Mejia L, Domenech M, Brewster A, Swartz MC, Strong L, Chandra J. Development and Feasibility of a Culturally Sensitive Cooking and Physical Activity Program Designed for Obese Hispanic Families. Infant, Child, & Adolescent Nutrition 20(10):1-8, 2015.
- Li R, Raber M, Chandra J. Developing a healthy web-based cookbook for pediatric cancer patients and survivors: rational and methods. JMIR Research Protocols 4(1), 2015. PMID: 25840596.
- Corrales-Medina FF, Manton CA, Orlowski RZ, Chandra J. Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models. Leukemia Research 39(3):371-9, 2015. PMID: 25612941.
- Braun FK, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLOS ONE 10(3), 2015. PMID: 25738497.
- Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology, 2015. PMID: 25795306.
- Santa Maria D, Swartz M, Markham C, Chandra J, McCurdy S, Basen-Engquist K. Exploring Parental Factors Related to Weight Management in Survivors of Childhood CNS Tumors. Journal of Pediatric Oncology Nursing 31(2):89-84, 2014. PMID: 24608701.
- Irwin ME, Nelson LD, Santiago-O'Farrill JM, Knouse PD, Miller CP, Palla SL, Siwak DR, Mills GB, Estrov Z, Li S, Hughes DP, Chandra J. Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Plos One 8(8):e70608, 2013. PMID: 23936456.
- Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM. Smooth muscle hyperplasia due to loss of smooth muscle a-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-B. Hum Mol Genet 22(15):3123-31, 2013. PMID: 23591991.
- Beltran A, Li R, Ater J, Baranowski J, Buday R, Thompson D, Chandra J, Baranowski T.. Adapting A Videogame to the Needs to Pediatric Cancer Patients and Survivors. Games for Health Journal 2(4):213-221, 2013. PMID: 26192225.
- Badr H, Chandra J, Paxton RJ, Ater JL, Urbauer D, Cruz CS, Demark-Wahnefried W. Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer. Journal of Cancer Survivorship 7(4):523-34, 2013. PMID: 23749663.
- Dent SY, Chandra J. The lasting influence of LSD1 in the blood. Elife 2(e00963):(e00963), 2013. PMID: 23795303.
- Singh MM, Irwin ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM, Chandra J. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer 118(13):3433-45, 2012. PMID: 22139798.
- Singh MM, Howard A, Irwin ME, Gao Y, Lu X, Multani A, Chandra J. Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. Plos One 7(12):e51611, 2012. PMID: 23284724.
- Miller CP, Manton C, Hale R, DeBose L, Macherla VR, Potts BC, Palladino MA, and Chandra J. Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs. Chemico-Biological Interactions 194(2011):58-68, 2011. PMID: 21864512.
- Singh M, Manton C, Bhat K, Tsai W-W, Aldape K, Barton M, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro-Oncology 13(8):894-903, 2011. PMID: 21653597.
- Hu J, Liu X, Hughes D, Esteva FJ, Liu B, Chandra J, and Li S. Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis. PLoS ONE(8):e23270, 2011. PMID: 21853100.
- Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R, Amin HM. Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukemia cells. J Cell Mol Med 14(6B):1777-92, 2010. PMID: 19508387.
- Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, Wheler J, Balasubramanian S, Chandra J. PCI-24781, a novel hydroxamic acid HDAC inhibitor, exerts cytotoxicity and histone alterations via caspase-8 and FADD in leukemia cells. Int J Cell Biol, 2010. PMID: 20145726.
- Howard AN, Bridges KA, Meyn RE, Chandra J. ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol 65(1):41-54, 2009. PMID: 19404643.
- Merritt WM, Danes CG, Shahzad MM, Lin YG, Kamat AA, Han LY, Spannuth WA, Nick AM, Mangala LS, Stone RL, Kim HS, Gershenson DM, Jaffe RB, Coleman RL, Chandra J, Sood AK. Anti-angiogenic Properties of Metronomic Topotecan in Ovarian Carcinoma. Cancer Biol Ther 8(16):1596-1603, 2009. PMID: 19738426.
- Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells is Mediated by Oxidative Stress. Cancer Res 69(9):3842-9, 2009. PMID: 19383922.
- Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood 113(18):4289-99, 2009. PMID: 19182209.
- Gao Y, Howard A, Ban K, Chandra J. Oxidative stress promotes transcriptional upregulation of Fyn in BCR-ABL1 expressing cells. J Biol Chem 284(11):7114-25, 2009. PMID: 19131339.
- Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood 111(5):2904-8, 2008. PMID: 18180382.
- Gao S, Mobley A, Miller C, Boklan J, Chandra J. Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leuk Res 32(5):771-80, 2008. PMID: 18031811.
- Miller CP, Ban K, Dujka ME, McConkey DJ, Munsell M, Palladino M, Chandra J.. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS -dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 110(1):267-277, 2007. PMID: 17356134.
- Long J, Manchandia T, Ban K, Gao S, Miller C, Chandra J. Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Cancer Chemother & Pharmaco 59(4):527-535, 2007. PMID: 16924499.
- Orsolic N, Golemovic M, Quintas-Cardama A, Scappini B, Manshouri T, Chandra J, Basic I, Giles F, Kantarjian H, Verstovsek S. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Science 97(9):952-960, 2006. PMID: 16822295.
- Ruiz S, Krupnik Y, Keating M, Chandra J, Palladino M, McConkey D.. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Molecular Cancer Therapeutics 5(7):1836-1843, 2006. PMID: 16891470.
- Chandra J, Tracy J, Loegering D, Flatten K, Verstovsek S, Beran M, Gorre M, Estrov Z, Donato N, Talpaz M, Sawyers C, Bhalla K, Karp J, Sausville E, Kaufmann SH. Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance. Blood 107:2501-2506, 2006. PMID: 16291594.
- Meng XW, Chandra J, Loegering D, Van Becelaere K, Kottke TJ, Gore SD, Karp JE, Sebolt-Leopold J, Kaufmann SH. Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro. J Biol Chem 278:47326-47339, 2003. PMID: 12963734.
- Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek LM, Narayanan VL, Adjei AA, Kay NE, Tefferi A, Karp JE, Sausville EA, Kaufmann SH. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood 102:4512-4519, 2003. PMID: 12920036.
- Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 277:20301-8, 2002. PMID: 11909872.
- Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99:664-671, 2002. PMID: 11781252.
- Chandra J, Mansson E, Gogvadze V, Kaufmann SH, Albertioni F, Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood 99:655-663, 2002. PMID: 11781251.
- Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Elenstrom-Magnusson C, Liu SX, Serinkan FB, Arroyo A, Chandra J, Orrenius S, Fadeel B. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol 169:487-499, 2002. PMID: 12077280.
- Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, Ljung J, Johansson M, Holmgren A. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 276:26269-26275, 2001. PMID: 11297543.
- Chandra J, Yang SN, Kohler M, Zaitsev S, Juntti-Berggren L, Berggren PO, Zhivotovsky B, Orrenius S. Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells. Diabetes 50 Suppl 1:S77-S81, 2001. PMID: 11272207.
- Lotfi K, Mansson E, Chandra J, Wang Y, Xu D, Knaust E, Spasokoukotskaja T, Liliemark E, Eriksson S, Albertioni F. Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide. Br J Haematol 113:339-346, 2001. PMID: 11380397.
- Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50 Suppl 1:S44-S47, 2001. PMID: 11272200.
- Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, Newman RA, Pathak S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia 2:339-345, 2000. PMID: 11005568.
- Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29:323-333, 2000. PMID: 11035261.
- Multani AS, Chandra J, McConkey J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent Chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res 11:455-460, 1999. PMID: 10850886.
- Bold RJ, Chandra J, McConkey DJ. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol 6:279-285, 1999. PMID: 10340887.
- Fadeel B, Gleiss B, Hogstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A. Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun 266:504-511, 1999. PMID: 10600532.
- Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 5:681-688, 1998. PMID: 9869513.
- Chandra J, Niemer I, Gilbreath J, Kliche KO, Andreeff M, Freireich EJ, Keating M, McConkey DJ. Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes. Blood 92:4220-4429, 1998. PMID: 9834227.
- Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem 272:3113-3117, 1997. PMID: 9388264.
- Chandra J, Gilbreath J, Freireich EJ, Kliche KO, Andreeff M, Keating M, McConkey DJ. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes. Blood 90:3673-3681, 1997. PMID: 9345052.
- McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M. Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol 156:2624-2630, 1996. PMID: 8786328.
Invited Articles
- Chandra J. Panobinostat, a pan-histone deacetylase inhibitor: rationale for and application to treatment of multiple myeloma. Drugs of Today--Prous Thomson Reuters 51(8):491-504, 2015. PMID: 26380387.
- Irwin ME, Rivera-Del Valle N, Chandra J. Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants & Redox Signaling 18(11):1349-83, 2013. PMID: 22900756.
- Co-Reyes E, Li R, Huh W, Chandra J. Malnutrition and Obesity in Pediatric Cancer Patients: Causes, Consequences, and Interventions. Pediatric Blood & Cancer 59(7):1160-1167, 2012. PMID: 22948929.
- Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan, D, Cusack Jr JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller C, Neuteboom STC, Ovaa H, Pajonk F, Roccaro AM, Sloss CM, Spear MA, Valash E, Younes A and Palladine MA. Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials. Current Cancer Drug Targets 11(3):254-284, 2011.
- Miller CP, Singh MM, Rivera-Del Valle N, Manton CA, Chandra J (corresponding author).. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inibitors. Journal of Biomedicine and Biotechnology, 2011. PMID: 21765634.
- Fulbright JM, Huh W, Anderson P, Chandra J. Can anthracycline therapy for pediatric malignancies be less cardiotoxic?. Current Oncology Reports 12(6):411-9, 2010. PMID: 20820959.
- Chandra J. Oxidative stress by targeted agents promotes cytotoxicity in hematological malignancies. Antioxid Redox Signal 11(5):1123-1127, 2009. PMID: 19018667.
Grant & Contract Support
| Title: | Defining and leveraging nutritional and circadian dependencies to augment acute leukemia treatment |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |