Joya Chandra, Ph.D.
Department of Pediatrics, Division of Pediatrics
About Dr. Chandra
Dr. Chandra and her team carry out translational pediatric oncology research directed towards leukemia and brain tumor therapeutics with an emphasis on cell signaling, oxidative stress, epigenetics and cell death. Novel therapeutics, primarily small molecule inhibitors that target these pathways and have potential to improve treatment outcomes for pediatric leukemia and brain tumor patients, are a major focus of the lab. The impact of modifiable behaviors on treatment efficacy and treatment outcomes are another focus of the lab. Consistent with her work on modifiable behaviors, she leads clinical research related to diet and nutrition for pediatric cancer patients and survivors. On an institutional level, she serves as co-Director of the Center for Energy Balance in Cancer Prevention and Survivorship. She values training of the next generation of biomedical researchers highly and is a mentor to trainees of all levels. She served as the 2019-2020 President of the Graduate Faculty of the MD Anderson UT Health Graduate School of Biomedical Sciences. She has been recognized for excellence in education by her institutional peers (2009 & 2013 Faculty Educator of the Month Awards) and by graduate students (through the 2012 McGovern Outstanding Teacher Award), and by the UT System (2016 Regents Outstanding Teaching Award, and induction into the UT Academy of Health Science Education in 2020). On a national scale, she serves on DOD and NIH study sections that are education and career oriented. Former pre and postdoctoral trainees have received F31 and F32 NRSA grants as trainees in her lab. She currently co-leads two NIH training grants: a R25 grant for summer undergraduate researchers at MD Anderson as well as the CCTS TL1 grant for pre- and post-doctoral fellows at UT Health and MD Anderson.
Education & Training
Degree-Granting Education
| 1998 | University of Texas Graduate School of Biomedical Sciences and M.D. Anderson Cancer Center, Houston, TX, USA, PhD, Cancer Biology and Immunology |
| 1993 | Louisiana State University, Baton Rouge, LA, USA, BS, Major: Microbiology, Minors: English and Spanish |
Postgraduate Training
| 2000-2002 | Postdoctoral Fellowship, Drug development, Apoptosis, Leukemia Therapy, Division of Oncology Research, Mayo Clinic, Rochester, MN |
| 1998-2000 | Postdoctoral Fellowship, Apoptosis, Oxidative stress, Division of Toxicology, Institute for Environmental Medicine, Karolinska Institute, Stockholm |
Experience & Service
Academic Appointments
Joint, Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2013 - 2021
Associate Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2021
Assistant Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2002 - 2008
Postdoctoral Research Assistant, Institute for Environmental Medicine, Karolinska Institute, Stockholm, 1999 - 2000
Graduate Research Assistant, Department of Cell Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 1994 - 1998
Research Technician, Department of Cell Biology, Baylor Medical School, Houston, TX, 1993 - 1994
Summer Research Intern, The University of Texas MD Anderson Cancer Center, Houston, TX, 1991 - Present
Administrative Appointments/Responsibilities
Member, Committee on Faculty Awards, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2012
Other Appointments/Responsibilities
Chair of the Executive Committee, National Board of TL1 Directors for CTSA's, Houston, TX, 2023 - Present
Member, Executive Committee, National Board of TL1 Directors, Houston, TX, 2022 - Present
Member, External Advisory Board, Ohio State University CTSA T32, Columbus, OH, 2022 - 2022
Member, External Advisory Board, St. Jude Lifetime Cohort, Houston, TX, 2022 - Present
President-elect, Graduate Faculty, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2019
Member, Executive Committee, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2021
Member, Program Metamorphosis Committee, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2015 - 2016
Member, Executive Committee for Experimental Therapeutics Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2010 - Present
Chair, Awards Committee for Experimental Therapeutics Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2010 - Present
Member, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Student Affairs Committee, Houston, TX, 2004 - 2007
Vice President, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Alumni Association, Houston, TX, 2004 - 2005
Member, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Alumni Association, Houston, TX, 2003 - 2008
Member, Graduate Faculty, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2002 - Present
Institutional Committee Activities
Reviewer, Start-up package Proposals, Department of Neurosurgery, 2023 - Present
Committee Member, Faculty Search, Department of Health Disparities, 2023 - Present
Chair Search, Committee Member, Department of Hematopoetic Biology and Malignancy, 2021 - 2023
Commitee Member, Faculty Search, Health Disparities, 2021 - 2022
Chair Committee, GSBS Student Recommendations During Covid 19, 2020 - Present
Committee Member, GSBS Task Force on Retaining Two Dean Model, 2020 - Present
Participant, SACS Site Visit, 2010 - Present
Participant, SACS Site Visit, 2005 - Present
Regular Member, Joint Student Affairs Council, University of Texas MD Anderson Cancer Center, 2005 - 2009
Member, New Agents Working Group, 2003 - 2008
Chair, Receptions Subcommittee, The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, 2003 - 2006
Member, Trainee Excellence Awards Subcommittee, The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, 2003 - 2006
Regular Member, The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, 2003 - 2009
Endowed Positions
Edgar Lewis Curtis, Savilla Elizabeth Curtis and Eleanor Lewis Curtis Distinguished Professor of Pediatric Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Honors & Awards
| 2020 | “Kenneth Shine” Academy for Health Science Education, The University of Texas System |
| 2019 | Academy for Health Science Education, The University of Texas MD Anderson |
| 2017 | President’s Recognition for Faculty Excellence in Education and Mentorship Advancement, The University of Texas MD Anderson |
| 2016 | Experimental Therapeutics Academic Program, Faculty Choice Award |
| 2016 | Highest Commendation for Service to the UTHSC GSBS, UTHSC Graduate School of Biomedical Sciences |
| 2016 | University of Texas System Regents Oustanding Teaching Award, University of Texas |
| 2015 | President's Recognition for Faculty Excellence |
| 2014 | Faculty Leadership Academy |
| 2014 | Texas Business Women’s Award |
| 2013 | Faculty Educator of the Month (April), The University of Texas MD Anderson Cancer Center |
| 2012 | John P. McGovern Outstanding Teacher Award, GSBS Graduate Student Association |
| 2009 | Faculty Educator of the Month (May), The University of Texas MD Anderson Cancer Center |
| 2004 | Leukemia SPORE Career Development Award |
| 2004 | Texas Federation of Business and Professional Women's Club Award |
| 2003 | Children's Oncology Group Young Investigator Award |
| 2003 | The University of Texas MD Anderson Cancer Center Institutional Research Grant |
| 2001 | NIH NRSA Individual (F32) Training Grant |
| 2001 | AACR-AFLAC Scholar-in-Training Award |
| 2000 | Wenner-Gren Foundation Fellowship for Visiting Scientists |
| 2000 | NIH NRSA Institutional (T32) Training Grant |
| 1999 | Karolinska Institute Fellowship for Visiting Scientists |
| 1999 | Travel Scholarship for Seventh European Conference on Apoptosis |
| 1997 | Special Commendation Award, University of Texas Graduate School of Biomedical Sciences |
| 1997 | American Legion Auxiliary Fellowship |
| 1997 | Andrew Sowell-Wade Huggins Endowed Scholarship |
| 1997 | Texas Regional Immunology Conference James W. McLaughlin Oral Award |
| 1997 | M.D. Anderson Associates Travel Award |
| 1997 | AACR-AFLAC Young Investigator Award |
| 1996 | John P. McGovern Award, University of Texas Graduate School of Biomedical Sciences |
| 1996 | Rhone-Poulenc Rorer Travel Award from American Association for Cancer Research (AACR) |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Jeyabal P, Bhagat A, Wang F, Roth M, Livingston JA, Gilchrist SC, Banchs J, Hildebrandt MAT, Chandra J, Deswal A, Koutroumpakis E, Wang J, Daw NC, Honey TA, Kleinerman ES. Circulating microRNAs and cytokines as prognostic biomarkers for doxorubicin-induced cardiac injury and for evaluating the effectiveness of an exercise intervention. Clin Cancer Res, 2023. PMID: 37651264.
- Jeans MR, Landry MJ, Vandyousefi S, Hudson EA, Burgermaster M, Bray MS, Chandra J, Davis JN. Effects of a School-Based Gardening, Cooking, and Nutrition Cluster Randomized Controlled Trial on Unprocessed and Ultra-Processed Food Consumption. J Nutr 153(7):2073-2084, 2023. PMID: 37116658.
- Figueroa M, Ma H, Alfayez M, Morales-Mantilla DE, Wang F, Lu Y, Estecio M, King KY, Kleinerman ES, Moghaddam SJ, Daver NG, Andreeff M, Konopleva MY, DiNardo CD, Chandra J. Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Adv, 2023. PMID: 37486624.
- Wooten SV, Amini B, Livingston JA, Hildebrandt MAT, Chandra J, Gilchrist SC, Roth M, Kleinerman E. Poor Sit-to-Stand Performance in Adolescent and Young Adult Patients with Sarcoma. J Adolesc Young Adult Oncol. e-Pub 2023. PMID: 37155195.
- Garcia MB, Schadler KL, Chandra J, Clinton SK, Courneya KS, Cruz-Monserrate Z, Daniel CR, Dannenberg AJ, Demark-Wahnefried W, Dewhirst MW, Fabian CJ, Hursting SD, Irwin ML, Iyengar NM, McQuade JL, Schmitz KH, Basen-Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer. CA Cancer J Clin 73(4):425-442, 2023. PMID: 36825928.
- Raber M, Costigan M,Chandra J, Basen-Engquist K. Cooking After Cancer: the Structure and Implementation of a Community-Based Cooking Program for Cancer Survivors. J Cancer Educ 37(3):539-545, 2022. PMID: 32754833.
- Wooten SV, Roth M, Livingston JA, Hildebrandt MAT, Chandra J, Amini B, Kleinerman ES, Gilchrist SC. Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients. J Adolesc Young Adult Oncol 11(3):320-322, 2022. PMID: 34388045.
- Kannan S, Irwin ME, Herbrich SM, Cheng T, Patterson LL, Aitken MJL, Bhalla K, You MJ, Konopleva M, Zweidler-McKay PA, Chandra J. Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy. Antioxidants (Basel) 11(4), 2022. PMID: 35453402.
- Wang F, Chandra J, Kleinerman ES. Exercise Intervention Decreases Acute and Late Doxorubicin-Induced Cardiotoxicity. Cancer Med 10(21):7572-7584, 2021. e-Pub 2021. PMID: 34523825.
- Bailey CP, Wang R, Figueroa M, Zhang S, Wang L, Chandra J. Computational immune infiltration analysis of pediatric high-grade gliomas (pHGGs) reveals differences in immunosuppression and prognosis by tumor location. Comput Syst Oncol 1(3), 2021. PMID: 34723252.
- Wartenburg L, Raber M, Chandra J. Unique features of a web-based nutrition website for childhood cancer populations : availability, features and content. Journal of Medical Internet Research 13(23):9, 2021. PMID: 32176517.
- van Dijk AD, Hoff FW, Qiu YH, Chandra J, Jabbour E, de Bont ESJM, Horton TM, Kornblau SM. Loss of H3K27M methylation identifies poor outcomes in adult-onset acute leukemia. Clinical Epigenetics 13(21), 2021. PMID: 33509276.
- Cheng T, Kiser KJ, Grasse LM, Iles LR, Bartholomeusz G, Samaniego F, Orlowski R,Chandra J. Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat. Cancer Drug Resistance 4(4), 2021. PMID: 34888496.
- Swartz MC, Teague AK, Wells SJ, Honey T, Fu M, Mahadeo KM, Kabiri LS, Chandra J, Moody K, Schadler K. Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer. J Clin Med 9(9), 2020. PMID: 32899945.
- Bailey CP, Figueroa M, Gangadharan A, Lee DA, Chandra J. Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol 11:2196, 2020. PMID: 33042135.
- Raber M, Baranowski T, Crawford K, Sharma SV, Schick V, Markham C, Jia W, Sun M, Steinman E, Chandra J. The Healthy Cooking Index: Nutrition Optimizing Home Food Preparation Practices across Multiple Data Collection Methods. J Acad Nutr Diet 120(7):1119-1132, 2020. PMID: 32280056.
- Sun Y, Bailey CP, Sadighi Z, Zaky W, Chandra J. Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. J Neurooncol, 2020. PMID: 32504402.
- Murphy BR, Raber MP, Crawford KD, Grasse L, Wartenberg L, Wu J, Dibaj SS, Chandra J. High Rates of Obesity at Presentation Persist into Survivorship across Childhood Cancer Types. Child Obes 16(4):250–257, 2020. PMID: 32176517.
- Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Wakefield CE, Chandra J. Meal planning values impacted by the cancer experience in families with school-aged survivors-a qualitative exploration and recommendations for intervention development. Support Care Cancer 28(3):1305-1313, 2020. PMID: 31243584.
- Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J. Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG). Neuro Oncol, 2020. PMID: 32166329.
- Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Chandra J. Exploring food preparation practices in families with and without school-aged childhood cancer survivors. Public Health Nutr 23(3):410-415, 2020. PMID: 31538553.
- Raber M, Basen-Engquist K, Moran NE, Chandra J. The Healthy Cooking Index does not Predict the Carotenoid Content of Home-Cooked Meals. Nutrients 12(2), 2020. PMID: 32092844.
- Cohen J, Collins L, Gregerson L,Chandra J, Cohn RJ. Nutritional concerns of survivors of childhood cancer: A "First World" perspective. Pediatr Blood Cancer:e28193, 2020. PMID: 31994836.
- Morales-Mantilla DE, Huang X, Erice P, Porter P, Zhang Y, Figueroa M,Chandra J, King KY, Kheradmand F, Rodríguez A. Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System. J Vis Exp(164), 2020. PMID: 33165327.
- Raber M, Wu J, Donnella H, Knouse P, Pise M, Munsell M, Liu D, Chandra J. Cellular Oxidative Stress in Pediatric Leukemia and Lymphoma Patients Undergoing Treatment Is Associated with Protein Consumption. Nutrients 12(1), 2019. PMID: 31892127.
- Kannan S, Aitken MJL, Herbrich SM, Golfman LS, Hall MG, Mak DH, Burks JK, Song G, Konopleva M, Mullighan CG, Chandra J, Zweidler-McKay PA. Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther 18(9):1615-1627, 2019. PMID: 31227645.
- Bailey CP, Figueroa M, Mohiuddin S, Zaky W, Chandra J. Cutting Edge Therapeutic Insights Derived from Molecular Biology of Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG). Bioengineering (Basel) 5(4), 2018. PMID: 30340362.
- Herbrich SM, Kannan S, Nolo RM, Hornbaker M, Chandra J, Zweidler-McKay PA. Characterization of TRKA signaling in acute myeloid leukemia. Oncotarget 9(53):30092-30105, 2018. PMID: 30046390.
- Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing. J Natl Compr Canc Netw 16(6):683-691, 2018. PMID: 29891519.
- Wang F, Iskra B, Kleinerman E, Alvarez-Florez C, Andrews T, Shaw A, Chandra J, Schadler K, Aune GJ. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity. J Pediatr Hematol Oncol 40(3):208-215, 2018. PMID: 29557918.
- Raber M, Huynh TN, Crawford K, Kim S,Chandra J. Development and Feasibility of a Community-Based, Culturally Flexible Colorectal Cancer Prevention Program. J Community Health, 2018. PMID: 29532214.
- Rivera-Del Valle N, Cheng T, Irwin ME, Donnella H, Singh MM, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol 81(3):483-495, 2018. PMID: 29313067.
- Schadler KL, Kleinerman ES, Chandra J. Diet and exercise interventions for pediatric cancer patients during therapy: tipping the scales for better outcomes. Pediatr Res 83(1-1):50-56, 2018. PMID: 29068433.
- Zaky W, Manton C, Miller CP, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer Metastasis Rev 36(4):617-633, 2017. PMID: 29071526.
- Raber M, Crawford K, Chandra J. Healthy cooking classes at a children's cancer hospital and patient/survivor summer camps: initial reactions and feasibility. Public Health Nutr:1-7, 2017. PMID: 28463101.
- Raber M, Chandra J, Upadhyaya M, Schick V, Strong LL, Durand C, Sharma S. An evidence-based conceptual framework of healthy cooking. Prev Med Rep 4:23-8, 2016. PMID: 27413657.
- Raber M, Swartz MC, Maria DS, O'Connor T, Baranowski T, Li R, Chandra J. Parental involvement in exercise and diet interventions for childhood cancer survivors: A systematic review. Pediatr Res, 2016. PMID: 27064243.
- Li R, Donnella H, Knouse P, Raber M, Crawford K, Swartz MC, Wu J, Liu D, Chandra J. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatr Blood Cancer, 2016. PMID: 27615542.
- Swartz MC, Basen-Engquist KM, Markham C, Lyons EJ, Cox M, Chandra J, Ater JL, Askins MA, Scheurer ME, Lupo PJ, Hill R, Murray J, Chan W, Swank PR. Psychometric Analysis of the Three-Factor Eating Questionnaire-R18V2 in Adolescent and Young Adult-Aged Central Nervous System Tumor Survivors. J Adolesc Young Adult Oncol 5(3):278-285, 2016. PMID: 27042872.
- Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep 6:18953, 2016. PMID: 26804704.
- Luan J, Chu Z, Chandra J, Zhang P. Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer. Curr Protein Pept Sci 17(5):455 - 462, 2016. PMID: 26796303.
- Fulbright JM, Egas-Bejar DE, Huh WW, Chandra J. Analysis of redox and apoptotic effects of anthracyclines to delineate a cardioprotective strategy. Cancer Chemother Pharmacol 76(6):1297-307, 2015. PMID: 26515054.
- Irwin M, Johnson B, Manshouri R, Amin H, Chandra J. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI resistant malignancies. Oncotarget 6(27):23631-46, 2015. PMID: 26136341.
- Li R, Raber M, Mejia L, Domenech M, Brewster A, Swartz MC, Strong L, Chandra J. Development and Feasibility of a Culturally Sensitive Cooking and Physical Activity Program Designed for Obese Hispanic Families. Infant, Child, & Adolescent Nutrition 20(10):1-8, 2015.
- Li R, Raber M, Chandra J. Developing a healthy web-based cookbook for pediatric cancer patients and survivors: rational and methods. JMIR Research Protocols 4(1), 2015. PMID: 25840596.
- Corrales-Medina FF, Manton CA, Orlowski RZ, Chandra J. Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models. Leukemia Research 39(3):371-9, 2015. PMID: 25612941.
- Braun FK, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLOS ONE 10(3), 2015. PMID: 25738497.
- Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology, 2015. PMID: 25795306.
- Santa Maria D, Swartz M, Markham C, Chandra J, McCurdy S, Basen-Engquist K. Exploring Parental Factors Related to Weight Management in Survivors of Childhood CNS Tumors. Journal of Pediatric Oncology Nursing 31(2):89-84, 2014. PMID: 24608701.
- Irwin ME, Nelson LD, Santiago-O'Farrill JM, Knouse PD, Miller CP, Palla SL, Siwak DR, Mills GB, Estrov Z, Li S, Hughes DP, Chandra J. Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Plos One 8(8):e70608, 2013. PMID: 23936456.
- Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM. Smooth muscle hyperplasia due to loss of smooth muscle a-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-B. Hum Mol Genet 22(15):3123-31, 2013. PMID: 23591991.
- Beltran A, Li R, Ater J, Baranowski J, Buday R, Thompson D, Chandra J, Baranowski T.. Adapting A Videogame to the Needs to Pediatric Cancer Patients and Survivors. Games for Health Journal 2(4):213-221, 2013. PMID: 26192225.
- Badr H, Chandra J, Paxton RJ, Ater JL, Urbauer D, Cruz CS, Demark-Wahnefried W. Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer. Journal of Cancer Survivorship 7(4):523-34, 2013. PMID: 23749663.
- Dent SY, Chandra J. The lasting influence of LSD1 in the blood. Elife 2(e00963):(e00963), 2013. PMID: 23795303.
- Singh MM, Irwin ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM, Chandra J. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer 118(13):3433-45, 2012. PMID: 22139798.
- Singh MM, Howard A, Irwin ME, Gao Y, Lu X, Multani A, Chandra J. Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. Plos One 7(12):e51611, 2012. PMID: 23284724.
- Miller CP, Manton C, Hale R, DeBose L, Macherla VR, Potts BC, Palladino MA, and Chandra J. Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs. Chemico-Biological Interactions 194(2011):58-68, 2011. PMID: 21864512.
- Singh M, Manton C, Bhat K, Tsai W-W, Aldape K, Barton M, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro-Oncology 13(8):894-903, 2011. PMID: 21653597.
- Hu J, Liu X, Hughes D, Esteva FJ, Liu B, Chandra J, and Li S. Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis. PLoS ONE(8):e23270, 2011. PMID: 21853100.
- Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R, Amin HM. Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukemia cells. J Cell Mol Med 14(6B):1777-92, 2010. PMID: 19508387.
- Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, Wheler J, Balasubramanian S, Chandra J. PCI-24781, a novel hydroxamic acid HDAC inhibitor, exerts cytotoxicity and histone alterations via caspase-8 and FADD in leukemia cells. Int J Cell Biol, 2010. PMID: 20145726.
- Howard AN, Bridges KA, Meyn RE, Chandra J. ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol 65(1):41-54, 2009. PMID: 19404643.
- Merritt WM, Danes CG, Shahzad MM, Lin YG, Kamat AA, Han LY, Spannuth WA, Nick AM, Mangala LS, Stone RL, Kim HS, Gershenson DM, Jaffe RB, Coleman RL, Chandra J, Sood AK. Anti-angiogenic Properties of Metronomic Topotecan in Ovarian Carcinoma. Cancer Biol Ther 8(16):1596-1603, 2009. PMID: 19738426.
- Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells is Mediated by Oxidative Stress. Cancer Res 69(9):3842-9, 2009. PMID: 19383922.
- Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood 113(18):4289-99, 2009. PMID: 19182209.
- Gao Y, Howard A, Ban K, Chandra J. Oxidative stress promotes transcriptional upregulation of Fyn in BCR-ABL1 expressing cells. J Biol Chem 284(11):7114-25, 2009. PMID: 19131339.
- Gao S, Mobley A, Miller C, Boklan J, Chandra J. Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leuk Res 32(5):771-80, 2008. PMID: 18031811.
- Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood 111(5):2904-8, 2008. PMID: 18180382.
- Miller CP, Ban K, Dujka ME, McConkey DJ, Munsell M, Palladino M, Chandra J.. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS -dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 110(1):267-277, 2007. PMID: 17356134.
- Long J, Manchandia T, Ban K, Gao S, Miller C, Chandra J. Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Cancer Chemother & Pharmaco 59(4):527-535, 2007. PMID: 16924499.
- Orsolic N, Golemovic M, Quintas-Cardama A, Scappini B, Manshouri T, Chandra J, Basic I, Giles F, Kantarjian H, Verstovsek S. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Science 97(9):952-960, 2006. PMID: 16822295.
- Ruiz S, Krupnik Y, Keating M, Chandra J, Palladino M, McConkey D. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Molecular Cancer Therapeutics 5(7):1836-1843, 2006. PMID: 16891470.
- Chandra J, Tracy J, Loegering D, Flatten K, Verstovsek S, Beran M, Gorre M, Estrov Z, Donato N, Talpaz M, Sawyers C, Bhalla K, Karp J, Sausville E, Kaufmann SH. Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance. Blood 107:2501-2506, 2006. PMID: 16291594.
- Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek LM, Narayanan VL, Adjei AA, Kay NE, Tefferi A, Karp JE, Sausville EA, Kaufmann SH. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood 102:4512-4519, 2003. PMID: 12920036.
- Meng XW, Chandra J, Loegering D, Van Becelaere K, Kottke TJ, Gore SD, Karp JE, Sebolt-Leopold J, Kaufmann SH. Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro. J Biol Chem 278:47326-47339, 2003. PMID: 12963734.
- Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Elenstrom-Magnusson C, Liu SX, Serinkan FB, Arroyo A, Chandra J, Orrenius S, Fadeel B. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol 169(1):487-499, 2002. PMID: 12077280.
- Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 277(23):20301-8, 2002. PMID: 11909872.
- Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99(2):664-671, 2002. PMID: 11781252.
- Lotfi K, Mansson E, Chandra J, Wang Y, Xu D, Knaust E, Spasokoukotskaja T, Liliemark E, Eriksson S, Albertioni F. Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide. Br J Haematol 113(2):339-346, 2002. PMID: 11380397.
- Chandra J, Mansson E, Gogvadze V, Kaufmann SH, Albertioni F, Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood 99(2):655-663, 2002. PMID: 11781251.
- Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, Ljung J, Johansson M, Holmgren A. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 276(28):26269-26275, 2001. PMID: 11297543.
- Chandra J, Yang SN, Kohler M, Zaitsev S, Juntti-Berggren L, Berggren PO, Zhivotovsky B, Orrenius S. Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells. Diabetes 50 Suppl 1:S77-S81, 2001. PMID: 11272207.
- Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50 Suppl 1:S44-S47, 2001. PMID: 11272200.
- Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29(3-4):323-333, 2000. PMID: 11035261.
- Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, Newman RA, Pathak S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia 2(4):339-345, 2000. PMID: 11005568.
- Fadeel B, Gleiss B, Hogstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A. Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun 266(2):504-511, 1999. PMID: 10600532.
- Bold RJ, Chandra J, McConkey DJ. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol 6:279-285, 1999. PMID: 10340887.
- Multani AS, Chandra J, McConkey J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent Chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res 11:455-460, 1999. PMID: 10850886.
- Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 5:681-688, 1998. PMID: 9869513.
- Chandra J, Niemer I, Gilbreath J, Kliche KO, Andreeff M, Freireich EJ, Keating M, McConkey DJ. Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes. Blood 92:4220-4429, 1998. PMID: 9834227.
- Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem 272(49):3113-3117, 1997. PMID: 9388264.
- Chandra J, Gilbreath J, Freireich EJ, Kliche KO, Andreeff M, Keating M, McConkey DJ. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes. Blood 90(9):3673-3681, 1997. PMID: 9345052.
- McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M. Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol 156(7):2624-2630, 1996. PMID: 8786328.
Invited Articles
- Chandra J. Panobinostat, a pan-histone deacetylase inhibitor: rationale for and application to treatment of multiple myeloma. Drugs of Today--Prous Thomson Reuters 51(8):491-504, 2015. PMID: 26380387.
- Irwin ME, Rivera-Del Valle N, Chandra J. Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants & Redox Signaling 18(11):1349-83, 2013. PMID: 22900756.
- Co-Reyes E, Li R, Huh W, Chandra J. Malnutrition and Obesity in Pediatric Cancer Patients: Causes, Consequences, and Interventions. Pediatric Blood & Cancer 59(7):1160-1167, 2012. PMID: 22948929.
- Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan, D, Cusack Jr JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller C, Neuteboom STC, Ovaa H, Pajonk F, Roccaro AM, Sloss CM, Spear MA, Valash E, Younes A and Palladine MA. Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials. Current Cancer Drug Targets 11(3):254-284, 2011.
- Miller CP, Singh MM, Rivera-Del Valle N, Manton CA, Chandra J (corresponding author).. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inibitors. Journal of Biomedicine and Biotechnology, 2011. PMID: 21765634.
- Fulbright JM, Huh W, Anderson P, Chandra J. Can anthracycline therapy for pediatric malignancies be less cardiotoxic?. Current Oncology Reports 12(6):411-9, 2010. PMID: 20820959.
- Chandra J. Oxidative stress by targeted agents promotes cytotoxicity in hematological malignancies. Antioxid Redox Signal 11(5):1123-1127, 2009. PMID: 19018667.
- Mow BM, Blajeski AL, Chandra J, Kaufmann SH. Apoptosis and the response to anticancer therapy. Curr Opin Oncol 13:453-462, 2001. PMID: 11673685.
- Robertson JD, Chandra J, Gogvadze V, Orrenius S. Biological reactive intermediates and mechanisms of cell death. Adv Exp Med Biol 500:1-10, 2001. PMID: 11764918.
- McConkey DJ, Chandra J. Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia. Leuk Lymphoma 33:421-431, 1999. PMID: 10342570.
Abstracts
- Chandra J, PHD. Preclinical and clinical strategies for treatment of pediatric malignancies incorporating epigenetic and metabolic vulnerabilities. ISC Plenary Session 2023, 2023.
- Stitzlein L, Gangadharan A, Grasse L, Espejo A, Singh M, Lu Y, Ezhilarasan R, Gumin J, Sulman E, Lang F, Chandra J. Evaluation of in vitro and in vivo efficacy of pharmacological lysine-specific demethylase 1 inhibitors in glioblastoma stem cell models. ASPET, 2023.
- Stitzlein L, Adams J, Luetzen M, Singh M, Su X, Lu Y, Ezhilarasan R, Gumin J, Sulman E, Lang F, Monje M, and Chandra J. Efficacy of LSD1-Directed Agents is Enhanced with Kinase Signaling Inhibition in Glioblastoma Stem Cells. Presented at ASPET, 2023.
- Rodriguez M, Figueroa M, Murphy B, Cheng T, Fekry B, Allton K, Barton M, Konopleva M, Mahan K, Chandra J. Effects of diet composition and timing on treatment for FLT3 positive acute myeloid leukemia. Presented at American Association for Cancer Research Annual Meeting 2022, 2022.
- Stitzlein L, Adams J, Luetzen M, Singh M, Su X, Lu Y, Ezhilarasan R, Gumin J, Sulman E, Lang F, Monje M, and Chandra J. Efficacy of kinase signaling inhibition is enhanced with LSD1 inhibition in high-grade glioma.. Presented at Therapeutics and Pharmacology Graduate Program Annual Retreat, 2022.
- Rivera-Del Valle N, Sausville E, Kaufmann S, Chandra J. Adaphostin, a tyrphostin kinase inhibitor, increases the cytotoxic effect of HDAC inhibitors, SNDX/MS-275 and vorinostat, in leukemia cells. Keystone Symposia on Targeted Cancer Therapies, 2009.
- Miller CP, Keating MJ, Wierda WG, Palladino M, Chandra J. Histone-H3 hyper-acetylation by a novel proteasome inhibitor, NPI-0052, is mediated by caspase-8 activation and reactive oxygen species. Keystone Symposia on Targeted Cancer Therapies, 2009.
- Miller CP, Palladino M, Chandra J. Overlapping functional activities of proteasome inhibitor, NPI-0052, and HDAC inhibitors contribute to synergistic cytotoxicity in leukemia cells. AACR Annual Meeting 2008, 2008.
- Howard A, Gao Y, Ban K, Chandra J. Upregulation of Fyn in CML occurs through ROS-dependent transcription by Sp1 and Egr-1. AACR Annual Meeting 2008, 2008.
- Gao S, Lu X, Sirisawad M, Steggerda S, Balasubramanian S, Chandra J. PCI-24781, a novel hydroxamic acid HDAC inhibitor, raises intracellular levels of reactive oxygen species, induces apoptosis and inhibits NFkB in leukemia models. AACR Annual Meeting 2008, 2008.
- Gao S, Miller C, Boklan J, Chandra J. Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemia cells. 49th Annual Meeting of American Society of Hematology, 2007.
- Chandra J , Howard A, Jensen K, Meyn R. Induction of oxidative stress and glutathone depletion by ABT-737, a novel small molecular inhibitor of Bcl-2, contributes to cytotoxicty in leukemia cells. 49th Annual Meeting of American Society of Hematology, 2007.
- Howard A, Ban K, Gao Y, Arlinghaus R, Amin H, Chandra J. Heightened Fyn expression in CML is BCR/ABL-and oxidant-dependent. 97th Annual Meeting of the American Association for Cancer Research, 2007.
- Nelson LD, Siwak DR, Lu Y, Mills GB, Miller C, Chandra J, Hughes DPM. ErbB signaling promotes BCR-Abl expression and modulates multiple signaling pathways as assessed by high-throughput reverse-phase protein array. 97th Annual Meeting of the American Association for Cancer Research, 2007.
- Gao S, Boklan J, Chandra J. Synergistic cytotoxic effects of MS-275 and 5-azacytidine in leukemia cells. 97th Annual Meeting of the American Association for Cancer Research, 2007.
- Miller C, Ban K, Ruiz S, Neuteboom S, Palladino M, McConkey D, Chandra J. The novel, orally active proteasome inhibitor, NPI-0052, induces apoptosis in leukemia lymphoma cell lines and patient specimens. 47th Annual Meeting of American Society of Hematology, 2005.
- Chandra Jand Ban K. Increased Superoxide Levels, HO-1 and Fyn Protein Expression in Bcr/abl Overexpressing Cells: Implications for Adaptation and Survival in an Oxidatively Challenging Environment. 47th Annual Meeting of the American Society of Hematology, 2005.
- Hughes D, Tracy J, Lee K, Zhang P, Estrov Z, and Chandra J. ERBB Expression in Philadelphia Chromosome-Positive ALL as a Potential Therapeutic Target. 47th Annual Meeting of the American Society of Hematology, 2005.
- Chandra J, Amin HM, Howard A, Miller CP. Fyn upregulation is a novel ROS-dependent mechanism controlling CML growth, progression and imatinib resistance. 48th Annual Meeting of the American Society of Hematology, 2005.
- Miller C, Ruiz S, Neuteboom S, Palladino M, McConkey D, Chandra J. Reactive oxygen species generation and caspase 8 activation are required for apoptosis induction by a novel proteasome inhibitor in lymphoid cells. 96th Annual Meeting of the American Association for Cancer Research, 2005.
- Miller C, Dujka M, Ruiz S, Neuteboom S, Palladino M, McConkey M, Chandra J. Apoptosis induction by a novel proteasome inhibitor relies on oxidant production and caspase-8 activation in lymphoid but not myeloid cells. Keystone Symposium on Cellular Senescence and Cell Death, 2005.
- Chandra J, Tracy J, Gorre M, Talpaz M, Griffin J, Verstovsek S, Beran M, Sawyers C, Sausville E, Kaufmann S. Effects of ROS production by adaphostin, a kinase inhibitor, on leukemia and myeloma cells. Winter SPORE Meeting for Hematological Malignancies, 2005.
- Miller C, Dujka M, Ruiz S, Neuteboom S, Palladino M, McConkey M, Chandra J. Preclinical evaluation of NPI-0052, an irreversible proteasome inhibitor, in hematological malignancies. Winter SPORE Meeting for Hematological Malignancies, 2005.
- Chandra J, Tracy J, Gorre M, Talpaz M, Griffin, J, Verstovsek S, Beran M, Sawyers C, Sausville, E, Kaufmann, S. Effects of adaphostin, a novel tyrphostin inhibitor, in diverse models of imatinib mesylate resistance. 46th Annual Meeting of the American Society of Hematology, 2004.
- Miller C, Dujka, M, Ruiz S, Neuteboom S, Palladino M, McConkey D, Chandra J. Distinct effects of proteasome inhibition by a novel inhibitor in lymphoid cells. EORTC-NCI-AACR Conference on Molecular Targets and Cancer Therapeutics, 2004.
- Ruiz, S, Krupnik, Y, Keating, M, Chandra, J, McConkey, D. Kinetics and Mechanism of Action of Bortezomib in Chronic Lymphocytic Leukemia. Leukemia 2004 Conference. Houston, Texas, USA, 2004.
- Chandra J, Tracy J, Gorre M, Talpaz M, Griffin J, Verstovsek S, Beran M, Sawyers C, Sausville E, Kaufmann SH. Effects of adaphostin, a novel tyrphostin inhibitor, in diverse models of imatinib mesylate resistance. Presentation at poster discussion session. 12th Annual SPORE Investigator's Workshop, 2004.
- Kumar S, Chandra J, Grote D, Cattaneo R, Kaufmann S, Fielding A. Bcl-2 over-expression results in decreased measles virus mediated cytotoxicity in lymphoma cell lines. 44th Annual Meeting of the American Society of Hematology, 2002.
- Chandra J, Mow B, Weisberg E, Griffin J, Sausville E, Kaufmann SH. Effects of the bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on leukemic cells in vitro. Poster Session. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, 2001.
- Chandra J, Mansson E, Gogvadze V, Albertioni F, Orrenius S. Resistance to 2-chlorodeoxyadenosine is mediated by mitochondrial effects associated with apoptosis. . Poster Session. Fernstrom Symposium: The Role of Mitochondria in Apoptosis and Neurodegeneration, 2000.
- Chandra J, Mansson E, Albertioni F, Orrenius S. Resistance to 2-chlorodeoxyadenosine is mediated by mitochondrial effects associated with apoptosis. Poster Session. American Association for Cancer Research, 2000.
- Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Effects of serum from patients with insulin-dependent diabetes mellitus on primary cerebellar granule cells. Poster Session. International Group on Insulin Secretion Symposium: Birth, Life and Death of a Beta-Cell in Type-2 Diabetes, 2000.
Book Chapters
- Figueroa M, Chandra J.. Cellular redox status and modifiable behaviors. In: Handbook on Oxidative Stress in Cancer. Springer International Publishing, 2021.
- Manton C, Chandra J. Oxidative stress and the proteasome: Mechanisms and therapeutic relevance. In: Resistance to Proteasome Inhibitors in Cancer. Springer International Publishing: Switzerland, 249-274, 2014.
- Chandra J, Miller C. Therapeutic Utility of Proteasome Inhibitors for Acute Leukemia. In: New Agents for the Treatment of Acute Lympoblastic Leukemia. Chapter 13. Springer, 273-298, 2011.
- Chandra J, Kaufmann SH. Apoptotic pathways in cancer progression and treatment. In: Signal Transduction and Human Health. John Wiley & Sons, Inc, 2003.
- Chandra J, Orrenius S. Mitochondria, oxygen metabolism and the regulation of cell death. In: Proceedings from the Third International Conference on Oxygen and Life. Elsevier Sciences, 2002.
- Chandra J, Orrenius S. Apoptosis and oxidative stress: Promotion, modulation and abrogation. In: Free Radicals in Chemistry, Biology and Medicine. OICA International UK Limited, 2000.