Ju-Seog Lee, PhD

Peer-Reviewed Articles

1. Lee WS, Woo S, Lee SH, Jo GH, Kim I, Kim H, An C, Jung S, Kim G, Kang H, Kang B, Kim JS, Lim HY, Kang I, Yang H, Kong SJ, Son D, Shin DJ, Kwon WY, Lee DY, Lee JS, Park J, Kim Y, Hwang S, Kim C, Chon HJ. Integrative Multi-Omics Profiling Identifies Infiltrative HCC as an Immunotherapy-Resistant Subtype with Distinct Molecular Features. Clin Mol Hepatol, 2025. e-Pub 2025. PMID: 41146520.
2. Feng T, Luo Q, Liu Y, Jin Z, Skwarchuk D, Lee R, Nam M, Asara JM, Adye DR, Lorenzi PL, Tan L, Pei G, Zhao Z, Zarrin-Khameh N, Paulucci-Holthauzen A, Simons BW, Lee JS, Kopetz S, Yun J. Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD. Nat Metab 7(10):2018-2032, 2025. e-Pub 2025. PMID: 40973819.
3. Bayraktar E, Rodriguez-Aguayo C, Stur E, Kumar S, Mangala LS, Jennings NB, Bayram NN, Corvigno S, Asare A, Ivan C, Kim MS, Vu TC, Hanjra P, Kim S, Ahumada AL, Wu W, Lee S, Szymanowska A, Oztatlici H, Estecio MR, Lee JS, Jain AK, Sahni N, Hagan JP, Baylin S, Liu J, Lopez-Berestein G, Pradeep S, Sood AK. Epigenetic modulation of BARD1 to enhance anti-VEGF therapy. Cell Rep Med 6(9):102329, 2025. e-Pub 2025. PMID: 40907495.
4. Lee, KJ, Ahn, JH, Kim, JH, Lee, YS, Lee, J, Lee, JH, Kim, TJ, Choi, JH. Non-coding RNA RMRP governs RAB31-dependent MMP secretion, enhancing ovarian cancer invasion. Biochimica et Biophysica Acta - Molecular Basis of Disease 1871(5), 2025. e-Pub 2025. PMID: 40057205.
5. Jeong MS, Baek SW, Yang GE, Mun JY, Kim JA, Kim TN, Nam JK, Choi YH, Lee JS, Chu IS, Leem SH. Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications. Cancer Lett 610:217339, 2025. e-Pub 2025. PMID: 39608442.
6. Jeong YS, Shin J, Kim SM, Sohn BH, Yim SY, Kim J, Shim J, Lee SH, Chun YS, Lee S, Dai H, Kaseb A, Kang KJ, Eltzschig HK, MacLeod A, Luo X, Revenko A, Kim Y, Lee J. Therapeutic Targeting of PEA15: A Novel Oncogenic Regulator of VHL and HIF1A Identified Through Proteomic Analysis in Liver Cancer. Cancer Communications. e-Pub 2025.
7. Yim SY, Kim H, Kang S, Choi E, Yoo YJ, Kang SH, Lee Y, Jung YK, Seo YS, Yim HJ, Yeon JE, Tang Y, Sohn B, Jeong YS, Park H, Liang H, Lee JS, Km JH. Genomic predictor of sorafenib efficacy in HCC and associated molecular and cellular characteristics. Journal of Hepatology. e-Pub 2025.
8. Park H, Park S, Park K, Yim SY, Lee JS, Lee SH. Hepatic Metabolic Signature and Its Association with the Response to Immunotherapy in Hepatocellular Carcinoma. Immunotargets Ther 14:787-798, 2025. e-Pub 2025. PMID: 40717708.
9. Jin H, Meng R, Li CS, Kim SH, Chai OH, Lee YH, Park BH, Lee JS, Kim SM. HN1-mediated activation of lipogenesis through Akt-SREBP signaling promotes hepatocellular carcinoma cell proliferation and metastasis. Cancer Gene Ther 31(11):1669-1687, 2024. e-Pub 2024. PMID: 39251779.
10. Keggenhoff FL, Castven D, Becker D, Stojkovic S, Castven J, Zimpel C, Straub BK, Gerber T, Langer H, Hähnel P, Kindler T, Fahrer J, O’Rourke CJ, Ehmer U, Saborowski A, Ma L, Wang XW, Gaiser T, Matter MS, Sina C, Derer-Petersen S, Lee J, Roessler S, Kaina B, Andersen JB, Galle PR, Marquardt JU. PARP1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma. Gut 73(10):1712-1724, 2024. e-Pub 2024. PMID: 38857989.
11. Yim SY, Lee SH, Baek S, Sohn B, Jeong YS, Kang S, Park K, Park H, Lee SS, Kaseb AO, Park YN, Chu I, Kim JH, Lee J. Genomic Biomarkers to Predict Response to Atezolizumab Plus Bevacizumab Immunotherapy in Hepatocellular Carcinoma: Insights from the IMbrave150 Trial. Clin Mol Hepatol, 2024. e-Pub 2024. PMID: 39038962.
12. Lee J, Patton ME, Kelekar S, Taylor LJ, Dean AE, Zuo Q, Thakare RN, Lee SH, Gentry E, Panitchpakdi M, Dorrestein P, Alnouti Y, Madak-Erdogan Z, Lee J, Finegold MJ, Anakk S. Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females. eLife. e-Pub 2024.
13. Chen R, Lee JS. miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration. Mol Ther Oncolytics 31:100725, 2023. e-Pub 2023. PMID: 37781339.
14. Jeong YS, Lee JS. Clinically conserved genomic subtypes of gastric adenocarcinoma. Mol Cancer 22(1):147, 2023. e-Pub 2023. PMID: 37674200.
15. Meng RY, Lee JS. Inhibition of the interaction between Hippo/YAP and Akt signaling with ursolic acid and 3'3-diindolylmethane suppresses esophageal cancer tumorigenesis. Korean J Physiol Pharmacol 27(5):493, 2023. e-Pub 2023. PMID: 37641811.
16. Kweon, SM, Irimia-Dominguez, J, Kim, G, Fueger, PT, Asahina, K, Lai, KK, Allende, D, Lai, QR, Lou, CH, Tsark, WM, Yang, JD, Ng, DS, Lee, JS, Tso, P, Huang, W, Lai, KK. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. American Journal of Physiology - Gastrointestinal and Liver Physiology 325(2):G147-G157, 2023. e-Pub 2023. PMID: 37129245.
17. Li, CS, Nguyen, TV, Chai, OH, Park, BH, Lee, JS, Kim, SM. 3,3′-Diindolylmethane Augments 5-Fluorouracil-InducedGrowth Suppression in Gastric Cancer Cells through Suppression of the Akt/GSK-3 β and WNT/Beta-Catenin. Journal of Oncology 2023, 2023. e-Pub 2023. PMID: 36785670.
18. Hu D, Meng RY, Nguyen TV, Chai OH, Park BH, Lee JS, Kim SM. Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway. Mol Med Rep 27(1), 2023. e-Pub 2023. PMID: 36382656.
19. Lee, SH, Yim, SY, Jeong, YS, Li, QX, Kang, S, Sohn, BH, Kumar, SV, Shin, J, Choi, YR, Shim, JJ, Kim, H, Kim, JH, Kim, S, Guo, S, Johnson, RL, Kaseb, A, Kang, KJ, Chun, YS, Jang, H, Lee, BG, Woo, HG, Ha, MJ, Akbani, R, Roberts, LR, Wheeler, DA, Lee, JS. Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes. Hepatology 76(6):1634-1648, 2022. e-Pub 2022. PMID: 35349735.
20. Jung J, Park S, Jang Y, Lee SH, Jeong YS, Yim SY, Lee JS. Clinical Significance of Glycolytic Metabolic Activity in Hepatocellular Carcinoma. Cancers 15(1):186, 2022. e-Pub 2022. PMID: 36612182.
21. Jang, H, Truong, CY, Lo, EM, Holmes, HM, Ramos, D, Ramineni, M, Lee, J, Wang, DY, Pietropaolo, M, Ripley, RT, Burt, BM, Lee, HS. Inhibition of Cyclin Dependent Kinase 4/6 Overcomes Primary Resistance to Programmed Cell Death 1 Blockade in Malignant Mesothelioma. Annals of Thoracic Surgery 114(5):1842-1852, 2022. e-Pub 2022. PMID: 34592265.
22. Fujita M, M-J C, Siwak DR, Sasagawa S, Oosawa-Tatsuguchi A, Arihiro K, Ono A, Miura R, Maejima K, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Lee JS, Lu Y, Mills GB, Liang H, Nishizuka SS, and Nakagawa H. Proteo-genomic Characterization of Virus-associated Liver Cancers Reveals Potential Subtypes and Therapeutic Targets. Nature Communication 13(1):6481, 2022. e-Pub 2022. PMID: 36309506.
23. Jang HJ, Lee HS, Yu W, Ramineni M, Truong CY, Ramos D, Splawn T, Choi JM, Jung SY, Lee JS, Wang DY, Sederstrom JM, Pietropaolo M, Kheradmand F, Amos CI, Wheeler TM, Ripley RT, Burt BM. Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment. Cancer Res 82(14):2593-2609, 2022. e-Pub 2022. PMID: 35709756.
24. Suh YS, Na D, Lee JS, Chae J, Kim E, Jang G, Lee J, Min J, Ock CY, Kong SH, George J, Zhang C, Lee HJ, Kim JI, Kim SJ, Kim WH, Lee C, Yang HK. Comprehensive Molecular Characterization of Adenocarcinoma of the Gastroesophageal Junction Between Esophageal and Gastric Adenocarcinomas. Ann Surg 275(4):706-717, 2022. e-Pub 2022. PMID: 33086305.
25. Kweon SM, Kim G, Jeong Y, Huang W, Lee JS, Lai KKY. Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo. Cancers (Basel) 14(6), 2022. e-Pub 2022. PMID: 35326575.
26. Lee SH, Jeong YS, Lee S, Sohn BH, Hwang HK, Choi GH, Kang CM, Choi JS, Lee WJ, Cheong JH, Jang HJ, Kaseb A, Roberts L, Yim SY, Chun YS, Lee JS. Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials. Cancer Commun (Lond) 42(2):179-183, 2022. e-Pub 2022. PMID: 35032367.
27. Hao D, He S, Harada K, Pizzi MP, Lu Y, Guan P, Chen L, Wang R, Zhang S, Sewastjanow-Silva M, Abdelhakeem A, Shanbhag N, Bhutani M, Han G, Lee JH, Zhao S, Weston B, Blum Murphy M, Waters R, Estrella JS, Roy-Chowdhuri S, Gan Q, Lee JS, Peng G, Hanash SM, Calin GA, Song X, Zhang J, Song S, Wang L, Ajani JA. Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma. Gut 70(11):2055-2065, 2021. e-Pub 2021. PMID: 33334899.
28. Nahm JH, Lee HS, Kim H, Yim SY, Shin JH, Yoo JE, Ahn SH, Choi JS, Lee JS, Park YN. Pathologic Predictive Factors for Late Recurrence of Hepatocellular Carcinoma in Chronic Liver Disease. Liver Int 41(7):1662-1674, 2021. e-Pub 2021. PMID: 33638929.
29. Kang, I, Lee, SH, Lee, SS, Lee, JS. Integrative multi-omics profiling for resectable hepatocellular carcinoma uncovers clinically available serum biomarkers to predict microvascular invasion. Annals of Hepato-Biliary-Pancreatic Surgery 25:S55, 2021. e-Pub 2021.
30. Park C, Jeong K, Park JH, Jung S, Bae JM, Kim K, Ock CY, Kim M, Keam B, Kim TM, Jeon YK, Lee SH, Lee JS, Kim DW, Kang GH, Chung DH, Heo DS. Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy. Cancer Immunol Immunother 70(6):1605-1617, 2021. e-Pub 2021. PMID: 33230567.
31. Shin MK, Kim J, Kim D, Lee SH, Shin JH, Jeong YS, Sohn BH, Kim J, Kim SR, Ajani JA, Lee JS, Cheong JH. Long non-coding RNAs are significantly associated with prognosis and response to therapies in gastric cancer. Clin Transl Med 11(6):e421, 2021. e-Pub 2021. PMID: 34185430.
32. Lee SH, Simoneau EB, Karpinets T, Futreal PA, Zhang J, Javle M, Zhang J, Vauthey JN, Lee JS, Estrella JS, Chun YS. Genomic Profiling of Multifocal Intrahepatic Cholangiocarcinoma Reveals Intraindividual Concordance of Genetic Alterations. Carcinogenesis 42(3):436-441, 2021. e-Pub 2021. PMID: 33200197.
33. Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 131(7), 2021. e-Pub 2021. PMID: 33792569.
34. Zhu C, Ho YJ, Salomao MA, Dapito DH, Bartolome A, Schwabe RF, Lee JS, Lowe SW, Pajvani UB. Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. J Hepatol 74(3):613-626, 2021. e-Pub 2021. PMID: 33038431.
35. Seo I, Lee HW, Byun SJ, Park JY, Min H, Lee SH, Lee JS, Kim S, Bae SU. Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer. J Immunother Cancer 9(3), 2021. e-Pub 2021. PMID: 33692216.
36. Lee YS, Bao X, Lee HH, Jang JJ, Saruuldalai E, Park G, Im WR, Park JL, Kim SY, Shin S, Jeon SH, Kang S, Lee HS, Lee JS, Zhang K, Park EJ, Kim IH, Lee YS. Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion. Int J Mol Sci 22(4), 2021. e-Pub 2021. PMID: 33670458.
37. Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, Pizzi MP, Scott A, Harada K, Ma L, Yao X, Jin J, Zhao W, Dong X, Badgwell BD, Shanbhag N, Tatlonghari G, Estrella JS, Roy-Chowdhuri S, Kobayashi M, Vykoukal JV, Hanash SM, Calin GA, Peng G, Lee JS, Johnson RL, Wang Z, Wang L, Song S. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut 70(1):55-66, 2021. e-Pub 2021. PMID: 32345613.
38. Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC. Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. Ann Surg 277(2):E366-E375, 2021. e-Pub 2021. PMID: 34387201.
39. Kim D, Nguyen QT, Lee J, Lee SH, Janocha A, Kim S, Le HT, Dvorina N, Weiss K, Cameron MJ, Asosingh K, Erzurum SC, Baldwin WM, Lee JS, Min B. Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism. Immunity 53(3):581-596.e5, 2020. e-Pub 2020. PMID: 32707034.
40. Yim SY, Kang SH, Shin JH, Jeong YS, Sohn BH, Um SH, Lee JS. Low ARID1A Expression is Associated with Poor Prognosis in Hepatocellular Carcinoma. Cells 9(9), 2020. e-Pub 2020. PMID: 32878261.
41. Miyake TM, Pradeep S, Bayraktar E, Stur E, Handley KF, Wu SY, Rodriguez-Aguayo C, Lee JS, Lopez-Berestein G, Coleman RL, Sood AK. NRG1/ERBB3 Pathway Activation Induces Acquired Resistance to XPO1 Inhibitors. Mol Cancer Ther 19(8):1727-1735, 2020. e-Pub 2020. PMID: 32499298.
42. Kim EH, Sohn BH, Eun YG, Lee DJ, Yim SY, Kang SG, Lee JS. Silence of Hippo Pathway Associates with Pro-Tumoral Immunosuppression: Potential Therapeutic Target of Glioblastomas. Cells 9(8), 2020. e-Pub 2020. PMID: 32717825.
43. Im WR, Lee HS, Lee YS, Lee JS, Jang HJ, Kim SY, Park JL, Lee Y, Kim MS, Lee JM, Kim IH, Jeon SH, Lee YS. A Regulatory Noncoding RNA, nc886, Suppresses Esophageal Cancer by Inhibiting the AKT Pathway and Cell Cycle Progression. Cells 9(4), 2020. e-Pub 2020. PMID: 32225025.
44. Kim SK, Ahn SG, Mun JY, Jeong MS, Bae SJ, Lee JS, Jeong J, Leem SH, Chu IS. Genomic Signature of the Standardized Uptake Value in 18F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer. Cancers (Basel) 12(2), 2020. e-Pub 2020. PMID: 32093417.
45. Wang R, Song S, Harada K, Ghazanfari Amlashi F, Badgwell B, Pizzi MP, Xu Y, Zhao W, Dong X, Jin J, Wang Y, Scott A, Ma L, Huo L, Vicente D, Blum Murphy M, Shanbhag N, Tatlonghari G, Thomas I, Rogers J, Kobayashi M, Vykoukal J, Estrella JS, Roy-Chowdhuri S, Han G, Zhang S, Mao X, Song X, Zhang J, Gu J, Johnson RL, Calin GA, Peng G, Lee JS, Hanash SM, Futreal A, Wang Z, Wang L, Ajani JA. Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response. Gut 69(1):18-31, 2020. e-Pub 2020. PMID: 31171626.
46. Roh JW, Choi JE, Han HD, Hu W, Matsuo K, Nishimura M, Lee JS, Kwon SY, Cho CH, Kim J, Coleman RL, Lopez-Bernstein G, Sood AK. Clinical and biological significance of EZH2 expression in endometrial cancer. Cancer Biol Ther 21(2):147-156, 2020. e-Pub 2020. PMID: 31640461.
47. Yim SY, Hae NJ, Shin JH, Jeong YS, Kang SH, Park YN, Um SH, Lee JS. Identification of prognostic biomarker in predicting hepatocarcinogenesis from cirrhotic liver using protein and gene signatures. Exp Mol Pathol 111:104319, 2019. e-Pub 2019. PMID: 31676327.
48. Kim J, Jo YH, Jang M, Nguyen NNY, Yun HR, Ko SH, Shin Y, Lee JS, Kang I, Ha J, Choi TG, Kim SS. PAC-5 Gene Expression Signature for Predicting Prognosis of Patients with Pancreatic Adenocarcinoma. Cancers (Basel) 11(11), 2019. e-Pub 2019. PMID: 31703415.
49. Kim SK, Kim SY, Kim CW, Roh SA, Ha YJ, Lee JL, Heo H, Cho DH, Lee JS, Kim YS, Kim JC. A prognostic index based on an eleven gene signature to predict systemic recurrences in colorectal cancer. Exp Mol Med 51(10):115, 2019. e-Pub 2019. PMID: 31578316.
50. Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N. MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. Hepatology 70(2):532-546, 2019. e-Pub 2019. PMID: 30153342.
51. Kunkeaw N, Lee YS, Im WR, Jang JJ, Song MJ, Yang B, Park JL, Kim SY, Ku Y, Kim Y, Kang S, Jo HR, Jeong JH, Lee HS, Lee JS, Kim HP, Johnson BH, Kim IH, Lee YS. Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound. Proc Natl Acad Sci U S A 116(17):8289-8294, 2019. e-Pub 2019. PMID: 30948645.
52. Kang S, Kim EH, Hwang JE, Shin JH, Jeong YS, Yim SY, Joo EW, Eun YG, Lee DJ, Sohn BH, Lee SH, Lim B, Lee JS. Prognostic significance of high metabolic activity in breast cancer: PET signature in breast cancer. Biochem Biophys Res Commun 511(1):185-191, 2019. e-Pub 2019. PMID: 30777332.
53. Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW. NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. Sci Rep 9(1):3369, 2019. e-Pub 2019. PMID: 30833661.
54. Hisamatsu T, McGuire M, Wu SY, Rupaimoole R, Pradeep S, Bayraktar E, Noh K, Hu W, Hansen JM, Lyons Y, Gharpure KM, Nagaraja AS, Mangala LS, Mitamura T, Rodriguez-Aguayo C, Eun YG, Rose J, Bartholomeusz G, Ivan C, Lee JS, Matsuo K, Frumovitz M, Wong KK, Lopez-Berestein G, Sood AK. PRKRA/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer. Mol Cancer Ther 18(1):162-172, 2019. e-Pub 2019. PMID: 30305341.
55. Lee G, Jeong YS, Kim DW, Kwak MJ, Koh J, Joo EW, Lee JS, Kah S, Sim YE, Yim SY. Clinical significance of APOB inactivation in hepatocellular carcinoma. Exp Mol Med 50(11):147, 2018. e-Pub 2018. PMID: 30429453.
56. Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS. Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer. Mol Cancer Res 16(11):1713-1723, 2018. e-Pub 2018. PMID: 30082483.
57. Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Deng C, Resar L, Research Network CGA, Weinstein JN, Mishra L, Akbani R. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell Syst 7(4):422-437.e7, 2018. e-Pub 2018. PMID: 30268436.
58. Lee DJ, Eun YG, Rho YS, Kim EH, Yim SY, Kang SH, Sohn BH, Kwon GH, Lee JS. Three distinct genomic subtypes of head and neck squamous cell carcinoma associated with clinical outcomes. Oral Oncol 85:44-51, 2018. e-Pub 2018. PMID: 30220319.
59. Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH, Park YS, Choi HS, Kweon MN, Pack CG, Lee JS, Mills GB, Myung SJ, Park YY. Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun 9(1):3599, 2018. e-Pub 2018. PMID: 30171186.
60. Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 128(7):3199, 2018. e-Pub 2018. PMID: 29809169.
61. Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH, Park YS, Choi HS, Kweon MN, Pack CG, Lee JS, Mills GB, Myung SJ, Park YY. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun 9(1):1920, 2018. e-Pub 2018. PMID: 29765046.
62. McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY. Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype. Cell Rep 23(7):2095-2106, 2018. e-Pub 2018. PMID: 29768207.
63. Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun 9(1):1777, 2018. e-Pub 2018. PMID: 29725014.
64. Ahn JH, Lee HS, Lee JS, Lee YS, Park JL, Kim SY, Hwang JA, Kunkeaw N, Jung SY, Kim TJ, Lee KS, Jeon SH, Lee I, Johnson BH, Choi JH, Lee YS. nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer. Nat Commun 9(1):1166, 2018. e-Pub 2018. PMID: 29563500.
65. Chung JH, Jung HR, Jung AR, Lee YC, Kong M, Lee JS, Eun YG. SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma. Sci Rep 8(1):1677, 2018. e-Pub 2018. PMID: 29374236.
66. Sohn BH, Park IY, Shin JH, Yim SY, Lee JS. Glutamine synthetase mediates sorafenib sensitivity in β-catenin-active hepatocellular carcinoma cells. Exp Mol Med 50(1):e421, 2018. e-Pub 2018. PMID: 29303508.
67. Lee HS, Jang HJ, Choi JM, Zhang J, de Rosen VL, Wheeler TM, Lee JS, Tu T, Jindra PT, Kerman RH, Jung SY, Kheradmand F, Sugarbaker DJ, Burt BM. Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma. JCI Insight 3(7), 2018. e-Pub 2018. PMID: 29618661.
68. Eun YG, Lee D, Lee YC, Sohn BH, Kim EH, Yim SY, Kwon KH, Lee JS. Clinical significance of YAP1 activation in head and neck squamous cell carcinoma. Oncotarget 8(67):111130-111143, 2017. e-Pub 2017. PMID: 29340043.
69. Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy D, Phan AT, Hawk E, Javle M, Lee JS, Torres HA, Rashid A, Lenzi R, Hassabo HM, Abaza Y, Shalaby AS, Lacin S, Morris J, Patt YZ, Amos CI, Khaderi SA, Goss JA, Jalal PK, Kaseb AO. Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol 15(11):1791-1799, 2017. e-Pub 2017. PMID: 28579181.
70. Ock CY, Hwang JE, Keam B, Kim SB, Shim JJ, Jang HJ, Park S, Sohn BH, Cha M, Ajani JA, Kopetz S, Lee KW, Kim TM, Heo DS, Lee JS. Genomic landscape associated with response to immunotherapies in major cancer types. Nat Commun 8(1):1050, 2017. e-Pub 2017. PMID: 29051489.
71. Cascone T, Xu L, Lin HY, Liu W, Tran HT, Liu Y, Howells K, Haddad V, Hanrahan E, Nilsson MB, Cortez MA, Giri U, Kadara H, Saigal B, Park YY, Peng W, Lee JS, Ryan AJ, Jüergensmeier JM, Herbst RS, Wang J, Langley RR, Wistuba II, Lee JJ, Heymach JV. The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non-Small Cell Lung Cancer. Clin Cancer Res 23(18):5489-5501, 2017. e-Pub 2017. PMID: 28559461.
72. Hwang JE, Ki MS, Kim K, Jung SH, Shim HJ, Bae WK, Hwang EC, Hur YH, Jeong O, Ryu SY, Park YK, Cho SH, Lee JS, Chung IJ. The optimal chemotherapeutic regimen in D2-resected locally advanced gastric cancer: a propensity score-matched analysis. Oncotarget 8(39):66559-66568, 2017. e-Pub 2017. PMID: 29029536.
73. Matondo A, Jo YH, Shahid M, Choi TG, Nguyen MN, Nguyen NNY, Akter S, Kang I, Ha J, Maeng CH, Kim SY, Lee JS, Kim J, Kim SS. The Prognostic 97 Chemoresponse Gene Signature in Ovarian Cancer. Sci Rep 7(1):9689, 2017. e-Pub 2017. PMID: 28851888.
74. Haemmerle M, Taylor ML, Gutschner T, Pradeep S, Cho MS, Sheng J, Lyons YM, Nagaraja AS, Dood RL, Wen Y, Mangala LS, Hansen JM, Rupaimoole R, Gharpure KM, Rodriguez-Aguayo C, Yim SY, Lee JS, Ivan C, Hu W, Lopez-Berestein G, Wong ST, Karlan BY, Levine DA, Liu J, Afshar-Kharghan V, Sood AK. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun 8(1):310, 2017. e-Pub 2017. PMID: 28827520.
75. Lee HS, Jang HJ, Shah R, Yoon D, Hamaji M, Wald O, Lee JS, Sugarbaker DJ, Burt BM. Genomic Analysis of Thymic Epithelial Tumors Identifies Novel Subtypes Associated with Distinct Clinical Features. Clin Cancer Res 23(16):4855-4864, 2017. e-Pub 2017. PMID: 28400429.
76. Lin EW, Karakasheva TA, Lee DJ, Lee JS, Long Q, Bass AJ, Wong KK, Rustgi AK. Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries. PLoS Genet 13(8):e1006938, 2017. e-Pub 2017. PMID: 28787442.
77. Kang DH, Lee DJ, Lee S, Lee SY, Jun Y, Kim Y, Kim Y, Lee JS, Lee DK, Lee S, Jho EH, Yu DY, Kang SW. Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. Nat Commun 8(1):40, 2017. e-Pub 2017. PMID: 28659575.
78. Weiler SME, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, Knaub M, Thomann S, Bissinger M, Wan S, Rössler S, Becker D, Gretz N, Lang H, Bergmann F, Ustiyan V, Kalin TV, Singer S, Lee JS, Marquardt JU, Schirmacher P, Kalinichenko VV, Breuhahn K. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. Gastroenterology 152(8):2037-2051.e22, 2017. e-Pub 2017. PMID: 28249813.
79. Li L, Karanika S, Yang G, Wang J, Park S, Broom BM, Manyam GC, Wu W, Luo Y, Basourakos S, Song JH, Gallick GE, Karantanos T, Korentzelos D, Azad AK, Kim J, Corn PG, Aparicio AM, Logothetis CJ, Troncoso P, Heffernan T, Toniatti C, Lee HS, Lee JS, Zuo X, Chang W, Yin J, Thompson TC. Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer. Sci Signal 10(480), 2017. e-Pub 2017. PMID: 28536297.
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82. Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR. Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma. Cancer Res 77(3):632-645, 2017. e-Pub 2017. PMID: 27872089.
83. Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, Joo J, Kim SC, Yun JS, Na KJ, Choi YL, Park JL, Kim SY, Lee YS, Han L, Liang H, Mak D, Burks JK, Zo JI, Sugarbaker DJ, Shim YM, Lee JS. Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer. Gut 66(2):215-225, 2017. e-Pub 2017. PMID: 27507904.
84. Sohn BH, Hwang JE, Jang HJ, Lee HS, Oh SC, Shim JJ, Lee KW, Kim EH, Yim SY, Lee SH, Cheong JH, Jeong W, Cho JY, Kim J, Chae J, Lee J, Kang WK, Kim S, Noh SH, Ajani JA, Lee JS. Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project. Clin Cancer Res, 2017. e-Pub 2017. PMID: 28747339.
85. Shahid M, Choi TG, Nguyen MN, Matondo A, Jo YH, Yoo JY, Nguyen NN, Yun HR, Kim J, Akter S, Kang I, Ha J, Maeng CH, Kim SY, Lee JS, Kim J, Kim SS. An 8-gene signature for prediction of prognosis and chemoresponse in non-small cell lung cancer. Oncotarget 7(52):86561-86572, 2016. e-Pub 2016. PMID: 27863408.
86. Lee KW, Lee SS, Hwang JE, Jang HJ, Lee HS, Oh SC, Lee SH, Sohn BH, Kim SB, Shim JJ, Jeong W, Cha M, Cheong JH, Cho JY, Lim JY, Park ES, Kim SC, Kang YK, Noh SH, Ajani JA, Lee JS. Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer. Clin Cancer Res 22(24):6228-6235, 2016. e-Pub 2016. PMID: 27654712.
87. Kim J, Lee GR, Kim H, Jo YJ, Hong SE, Lee J, Lee HI, Jang YS, Oh SH, Lee HJ, Lee JS, Jeong W. Effective killing of cancer cells and regression of tumor growth by K27 targeting sulfiredoxin. Free Radic Biol Med 101:384-392, 2016. e-Pub 2016. PMID: 27825965.
88. Shim JJ, Oh IH, Kim SB, Kim JW, Lee CK, Jang JY, Lee JS, Kim BH. Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B. Gut Liver 10(6):962-968, 2016. e-Pub 2016. PMID: 27282260.
89. Lee EK, Hong SH, Shin S, Lee HS, Lee JS, Park EJ, Choi SS, Min JW, Park D, Hwang JA, Johnson BH, Jeon SH, Kim IH, Lee YS, Lee YS. nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer. Oncotarget 7(46):75000-75012, 2016. e-Pub 2016. PMID: 27612419.
90. Hatakeyama H, Wu SY, Lyons YA, Pradeep S, Wang W, Huang Q, Court KA, Liu T, Nie S, Rodriguez-Aguayo C, Shen F, Huang Y, Hisamatsu T, Mitamura T, Jennings N, Shim J, Dorniak PL, Mangala LS, Petrillo M, Petyuk VA, Schepmoes AA, Shukla AK, Torres-Lugo M, Lee JS, Rodland KD, Fagotti A, Lopez-Berestein G, Li C, Sood AK. Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers. Cell Rep 17(6):1621-1631, 2016. e-Pub 2016. PMID: 27806300.
91. Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64(5):1757-1772, 2016. e-Pub 2016. PMID: 27531557.
92. Shahid M, Cho KM, Nguyen MN, Choi TG, Jo YH, Aryal SN, Yoo JY, Yun HR, Lee JW, Eun YG, Lee JS, Kang I, Ha J, Yoon HJ, Kim SY, Kim SS. Prognostic value and their clinical implication of 89-gene signature in glioma. Oncotarget 7(32):51237-51250, 2016. e-Pub 2016. PMID: 27323413.
93. Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 30(2):363-365, 2016. e-Pub 2016. PMID: 27505680.
94. Chen J, Katz LH, Muñoz NM, Gu S, Shin JH, Jogunoori WS, Lee MH, Belkin MD, Kim SB, White JC, Andricovich J, Tzatsos A, Li S, Kim SS, Shetty K, Mishra B, Rashid A, Lee JS, Mishra L. Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. Sci Rep 6:30217, 2016. e-Pub 2016. PMID: 27456065.
95. Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget 7(26):40252-40265, 2016. e-Pub 2016. PMID: 27259233.
96. Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell 29(6):922-34, 2016. e-Pub 2016. PMID: 27300438.
97. Maass T, Marquardt J, Lee JS, Krupp M, Scholz-Kreisel P, Mogler C, Schirmacher P, Müller M, Westphal H, Galle PR, Teufel A. Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice. Oncotarget 7(20):28903-13, 2016. e-Pub 2016. PMID: 25826080.
98. Ock CY, Keam B, Kim S, Lee JS, Kim M, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS. Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration. Clin Cancer Res 22(9):2261-70, 2016. e-Pub 2016. PMID: 26819449.
99. Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun 7:11169, 2016. e-Pub 2016. PMID: 27041221.
100. Ock CY, Kim S, Keam B, Kim M, Kim TM, Kim JH, Jeon YK, Lee JS, Kwon SK, Hah JH, Kwon TK, Kim DW, Wu HG, Sung MW, Heo DS. PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma. Oncotarget 7(13):15901-14, 2016. e-Pub 2016. PMID: 26893364.
101. Sohn BH, Shim JJ, Kim SB, Jang KY, Kim SM, Kim JH, Hwang JE, Jang HJ, Lee HS, Kim SC, Jeong W, Kim SS, Park ES, Heo J, Kim YJ, Kim DG, Leem SH, Kaseb A, Hassan MM, Cha M, Chu IS, Johnson RL, Park YY, Lee JS. Inactivation of hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma. Clin Cancer Res 22(5):1256-64, 2016. e-Pub 2016. PMID: 26459179.
102. Kim H, Lee GR, Kim J, Baek JY, Jo YJ, Hong SE, Kim SH, Lee J, Lee HI, Park SK, Kim HM, Lee HJ, Chang TS, Rhee SG, Lee JS, Jeong W. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med 91:264-74, 2016. e-Pub 2016. PMID: 26721593.
103. Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S. The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development 143(1):133-46, 2016. e-Pub 2016. PMID: 26657772.
104. Park YY, Sohn BH, Johnson RL, Kang MH, Kim SB, Shim JJ, Mangala LS, Kim JH, Yoo JE, Rodriguez-Aguayo C, Pradeep S, Hwang JE, Jang HJ, Lee HS, Rupaimoole R, Lopez-Berestein G, Jeong W, Park IS, Park YN, Sood AK, Mills GB, Lee JS. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology 63(1):159-72, 2016. e-Pub 2016. PMID: 26389641.
105. Thompson SM, Callstrom MR, Jondal DE, Butters KA, Knudsen BE, Anderson JL, Lien KR, Sutor SL, Lee JS, Thorgeirsson SS, Grande JP, Roberts LR, Woodrum DA. Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress. PLoS One 11(9):e0162634, 2016. e-Pub 2016. PMID: 27611696.
106. Hl K, Lee HS, Kim TH, Lee JS, Lee ST, Lee SJ. Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. Oncotarget 6(40):42905-22, 2015. e-Pub 2015. PMID: 26556867.
107. Lee SR, Roh YG, Kim SK, Lee JS, Seol SY, Lee HH, Kim WT, Kim WJ, Heo J, Cha HJ, Kang TH, Chung JW, Chu IS, Leem SH. Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer. Clin Cancer Res 21(23):5391-403, 2015. e-Pub 2015. PMID: 26268246.
108. Maynard JP, Lee JS, Sohn BH, Yu X, Lopez-Terrada D, Finegold MJ, Goss JA, Thevananther S. P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients. Oncotarget 6(38):41162-79, 2015. e-Pub 2015. PMID: 26517690.
109. Lin SJ, Gagnon-Bartsch JA, Tan IB, Earle S, Ruff L, Pettinger K, Ylstra B, van Grieken N, Rha SY, Chung HC, Lee JS, Cheong JH, Noh SH, Aoyama T, Miyagi Y, Tsuburaya A, Yoshikawa T, Ajani JA, Boussioutas A, Yeoh KG, Yong WP, So J, Lee J, Kang WK, Kim S, Kameda Y, Arai T, Zur Hausen A, Speed TP, Grabsch HI, Tan P. Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas. Gut 64(11):1721-31, 2015. e-Pub 2015. PMID: 25385008.
110. Nguyen MN, Choi TG, Nguyen DT, Kim JH, Jo YH, Shahid M, Akter S, Aryal SN, Yoo JY, Ahn YJ, Cho KM, Lee JS, Choe W, Kang I, Ha J, Kim SS. CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer. Oncotarget 6(31):31674-92, 2015. e-Pub 2015. PMID: 26397224.
111. Karakasheva TA, Waldron TJ, Eruslanov E, Kim SB, Lee JS, O'Brien S, Hicks PD, Basu D, Singhal S, Malavasi F, Rustgi AK. CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. Cancer Res 75(19):4074-85, 2015. e-Pub 2015. PMID: 26294209.
112. Ji J, Eggert T, Budhu A, Forgues M, Takai A, Dang H, Ye Q, Lee JS, Kim JH, Greten TF, Wang XW. Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma. Hepatology 62(2):481-95, 2015. e-Pub 2015. PMID: 25833323.
113. Trinh BQ, Barengo N, Kim SB, Lee JS, Zweidler-McKay PA, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1/NF-κB signaling. J Cell Sci, 2015. e-Pub 2015. PMID: 26208636.
114. Hassan MM, Abdel-Wahab R, Kaseb A, Shalaby A, Phan AT, El-Serag HB, Hawk E, Morris J, Singh Raghav KP, Lee JS, Vauthey JN, Bortus G, Torres HA, Amos CI, Wolff RA, Li D. Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma. Gastroenterology 149(1):119-29, 2015. e-Pub 2015. PMID: 25836985.
115. Akter S, Choi TG, Nguyen MN, Matondo A, Kim JH, Jo YH, Jo A, Shahid M, Jun DY, Yoo JY, Nguyen NN, Seo SW, Ali L, Lee JS, Yoon KS, Choe W, Kang I, Ha J, Kim J, Kim SS. Prognostic value of a 92-probe signature in breast cancer. Oncotarget 6(17):15662-80, 2015. e-Pub 2015. PMID: 25883221.
116. Abdel-Wahab R, Shehata S, Hassan MM, Xiao L, Lee JS, Cheung S, Essa HH, Hassabo HM, Shalaby AS, Mosad E, Raghav K, Rashid A, Wolff RA, Morris JS, Amin HM, Kaseb AO. Validation of an IGF-CTP scoring system for assessing hepatic reserve in egyptian patients with hepatocellular carcinoma. Oncotarget, 2015. e-Pub 2015. PMID: 26098859.
117. Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani SA, Clise-Dwyer K, Sun X. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. Blood 125(19):2968-73, 2015. e-Pub 2015. PMID: 25712988.
118. Long A, Giroux V, Whelan KA, Hamilton KE, Tétreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis 36(5):598-606, 2015. e-Pub 2015. PMID: 25795715.
119. Lee KW, Lee SS, Kim SB, Sohn BH, Lee HS, Jang HJ, Park YY, Kopetz S, Kim SS, Oh SC, Lee JS. Significant Association of oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients. Clin Cancer Res 21(2):357-64, 2015. e-Pub 2015. PMID: 25388162.
120. Wen Y, Graybill WS, Previs RA, Hu W, Ivan C, Mangala LS, Zand B, Nick AM, Jennings NB, Dalton HJ, Sehgal V, Ram P, Lee JS, Vivas-Mejia PE, Coleman RL, Sood AK. Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 21(2):448-59, 2015. e-Pub 2015. PMID: 25416196.
121. Kim JY, Shin E, Kim JW, Lee HS, Lee DW, Kim SH, Lee JO, Kim YJ, Kim JH, Bang SM, Ahn SH, Park do J, Lee JS, Lee JS, Kim HH, Lee KW. Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer. PLoS One 10(3):e0120324, 2015. e-Pub 2015. PMID: 25793299.
122. Kwon SM, Kang SH, Park CK, Jung S, Park ES, Lee JS, Kim SH, Woo HG. Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance. PLoS One 10(10):e0140528, 2015. e-Pub 2015. PMID: 26466313.
123. Lee S, Lee TA, Lee E, Kang S, Park A, Kim SW, Park HJ, Yoon JH, Ha SJ, Park T, Lee JS, Cheon JH, Park B. Identification of a subnuclear body involved in sequence-specific cytokine RNA processing. Nat Commun 6:5791, 2015. e-Pub 2015. PMID: 25557830.
124. Yuan S, Lu Y, Yang J, Chen G, Kim S, Feng L, Ogasawara M, Hammoudi N, Lu W, Zhang H, Liu J, Colman H, Lee JS, Li XN, Xu RH, Huang P, Wang F. Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism. Stem Cell Res Ther 6(1):198, 2015. e-Pub 2015. PMID: 26472041.
125. Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD. Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nat Commun 6:5944, 2015. e-Pub 2015. PMID: 25661872.
126. Kim JH, Sohn BH, Lee HS, Kim SB, Yoo JE, Park YY, Jeong W, Lee SS, Park ES, Kaseb A, Kim BH, Kim WB, Yeon JE, Byun KS, Chu IS, Kim SS, Wang XW, Thorgeirsson SS, Luk JM, Kang KJ, Heo J, Park YN, Lee JS. Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation. PLoS Med 11(12):e1001770, 2014. e-Pub 2014. PMID: 25536056.
127. Chen G, Chakravarti N, Aardalen K, Lazar AJ, Tetzlaff MT, Wubbenhorst B, Kim SB, Kopetz S, Ledoux AA, Gopal YN, Pereira CG, Deng W, Lee JS, Nathanson KL, Aldape KD, Prieto VG, Stuart D, Davies MA. Molecular Profiling of Patient-Matched Brain and Extracranial Melanoma Metastases Implicates the PI3K Pathway as a Therapeutic Target. Clin Cancer Res 20(21):5537-46, 2014. e-Pub 2014. PMID: 24803579.
128. Lee KB, Ye S, Park MH, Park BH, Lee JS, Kim SM. p63-Mediated activation of the β-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis. Cancer Lett 353(1):124-32, 2014. e-Pub 2014. PMID: 25045846.
129. Research Network CGA. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513(7517):202-9, 2014. e-Pub 2014. PMID: 25079317.
130. Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella J, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. Carcinogenesis 35(9):2031-8, 2014. e-Pub 2014. PMID: 24990617.
131. Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 26(1):77-91, 2014. e-Pub 2014. PMID: 25026212.
132. Mallampati S, Sun B, Lu Y, Ma H, Gong Y, Wang D, Lee JS, Lin K, Sun X. Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1ε. Blood 123(26):4064-76, 2014. e-Pub 2014. PMID: 24786772.
133. Hu W, Liu T, Ivan C, Sun Y, Huang J, Mangala LS, Miyake T, Dalton HJ, Pradeep S, Rupaimoole R, Previs RA, Han HD, Bottsford-Miller J, Zand B, Kang Y, Pecot CV, Nick AM, Wu SY, Lee JS, Sehgal V, Ram P, Liu J, Tucker SL, Lopez-Berestein G, Baggerly KA, Coleman RL, Sood AK. Notch3 pathway alterations in ovarian cancer. Cancer Res 74(12):3282-93, 2014. e-Pub 2014. PMID: 24743243.
134. Lee HS, Lee K, Jang HJ, Lee GK, Park JL, Kim SY, Kim SB, Johnson BH, Zo JI, Lee JS, Lee YS. Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesis. Oncotarget 5(11):3472-81, 2014. e-Pub 2014. PMID: 25004084.
135. Lee KS, Park JL, Lee K, Richardson LE, Johnson BH, Lee HS, Lee JS, Kim SB, Kwon OH, Song KS, Kim YS, Ashktorab H, Smoot DT, Jeon SH, Kim SY, Lee YS. nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer. Oncotarget 5(11):3944-55, 2014. e-Pub 2014. PMID: 25003254.
136. Kim SK, Roh YG, Park K, Kang TH, Kim WJ, Lee JS, Leem SH, Chu IS. Expression signature defined by FOXM1-CCNB1 activation predicts disease recurrence in non-muscle-invasive bladder cancer. Clin Cancer Res 20(12):3233-43, 2014. e-Pub 2014. PMID: 24714775.
137. Ye S, Lee KB, Park MH, Lee JS, Kim SM. p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway. Int J Oncol 44(6):2153-9, 2014. e-Pub 2014. PMID: 24718831.
138. Li L, Chang W, Yang G, Ren C, Park S, Karantanos T, Karanika S, Wang J, Yin J, Shah PK, Takahiro H, Dobashi M, Zhang W, Efstathiou E, Maity SN, Aparicio AM, Li Ning Tapia EM, Troncoso P, Broom B, Xiao L, Lee HS, Lee JS, Corn PG, Navone N, Thompson TC. Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. Sci Signal 7(326):ra47, 2014. e-Pub 2014. PMID: 24847116.
139. Roh JW, Huang J, Hu W, Yang X, Jennings NB, Sehgal V, Sohn BH, Han HD, Lee SJ, Thanapprapasr D, Bottsford-Miller J, Zand B, Dalton HJ, Previs RA, Davis AN, Matsuo K, Lee JS, Ram P, Coleman RL, Sood AK. Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. Clin Cancer Res 20(10):2740-50, 2014. e-Pub 2014. PMID: 24634380.
140. Kaseb AO, Xiao L, Hassan MM, Chae YK, Lee JS, Vauthey JN, Krishnan S, Cheung S, Hassabo HM, Aloia T, Conrad C, Curley SA, Vierling JM, Jalal P, Raghav K, Wallace M, Rashid A, Abbruzzese JL, Wolff RA, Morris JS. Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma. J Natl Cancer Inst 106(5), 2014. e-Pub 2014. PMID: 24815863.
141. Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol Cancer Res 12(4):527-38, 2014. e-Pub 2014. PMID: 24515801.
142. Staib F, Krupp M, Maass T, Itzel T, Weinmann A, Lee JS, Schmidt B, Müller M, Thorgeirsson SS, Galle PR, Teufel A. CellMinerHCC: a microarray-based expression database for hepatocellular carcinoma cell lines. Liver Int 34(4):621-31, 2014. e-Pub 2014. PMID: 24016071.
143. Jeong W, Kim SB, Sohn BH, Park YY, Park ES, Kim SC, Kim SS, Johnson RL, Birrer M, Bowtell DS, Mills GB, Sood A, Lee JS. Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer. Anticancer Res 34(2):811-7, 2014. e-Pub 2014. PMID: 24511017.
144. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet 46(1):17-23, 2014. e-Pub 2014. PMID: 24270360.
145. Kaseb AO, Shah NN, Hassabo HM, Morris JS, Xiao L, Abaza YM, Soliman K, Lee JS, Vauthey JN, Wallace M, Aloia TA, Curley S, Abbruzzese JL, Hassan MM. Reassessing Hepatocellular Carcinoma Staging in a Changing Patient Population. Oncology 86(2):63-71, 2014. e-Pub 2014. PMID: 24401634.
146. White DL, Liu Y, Garcia J, El-Serag HB, Jiao L, Tsavachidis S, Franco LM, Lee JS, Tavakoli-Tabasi S, Moore D, Goldman R, Kuzniarek J, Ramsey DJ, Kanwal F, Marcelli M. Sex hormone pathway gene polymorphisms are associated with risk of advanced hepatitis C-related liver disease in males. Int J Mol Epidemiol Genet 5(3):164-76, 2014. e-Pub 2014. PMID: 25379136.
147. Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nat Commun 5:3459, 2014. e-Pub 2014. PMID: 24619206.
148. Woo HG, Kim SS, Cho H, Kwon SM, Cho HJ, Ahn SJ, Park ES, Lee J, Cho SW, Cheong JY. Profiling of Exome Mutations Associated with Progression of HBV-Related Hepatocellular Carcinoma. PLoS One 9(12):e115152, 2014. e-Pub 2014. PMID: 25521761.
149. Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash S, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5:3361, 2014. e-Pub 2014. PMID: 24553445.
150. Kim SH, Wang D, Park YY, Katoh H, Margalit O, Sheffer M, Wu H, Holla VR, Lee JS, DuBois RN. HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways. Cancer Lett 341(2):159-65, 2013. e-Pub 2013. PMID: 23916472.
151. Lim JY, Yoon SO, Seol SY, Hong SW, Kim JW, Choi SH, Lee JS, Cho JY. Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype. World J Gastroenterol 19(41):7078-88, 2013. e-Pub 2013. PMID: 24222951.
152. Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, Emmett MJ, Stanger BZ, Lee JS, Rustgi AK. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev 27(20):2233-45, 2013. e-Pub 2013. PMID: 24142874.
153. Park ES, Lee JS. Correspondence to 11-1370.R2. Hepatology 58(3):1192, 2013. e-Pub 2013. PMID: 23463291.
154. Wu Y, Grabsch H, Ivanova T, Tan IB, Murray J, Ooi CH, Wright AI, West NP, Hutchins GG, Wu J, Lee M, Lee J, Koo JH, Yeoh KG, van Grieken N, Ylstra B, Rha SY, Ajani JA, Cheong JH, Noh SH, Lim KH, Boussioutas A, Lee JS, Tan P. Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer. Gut 62(8):1100-11, 2013. e-Pub 2013. PMID: 22735568.
155. Park YY, Kim SB, Han HD, Sohn BH, Kim JH, Liang J, Lu Y, Rodriguez-Aguayo C, Lopez-Berestein G, Mills GB, Sood AK, Lee JS. TARDBP regulates glycolysis in hepatocellular carcinoma by regulating PFKP through miR-520. Hepatology 58(1):182-91, 2013. e-Pub 2013. PMID: 23389994.
156. Yang Y, Mallampati S, Sun B, Zhang J, Kim SB, Lee JS, Gong Y, Cai Z, Sun X. Wnt pathway contributes to the protection by bone marrow stromal cells of acute lymphoblastic leukemia cells and is a potential therapeutic target. Cancer Lett 333(1):9-17, 2013. e-Pub 2013. PMID: 23333798.
157. Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, Hawke D, Kim SM, Lee JS, Goltsov AA, Park S, Ittmann MM, Troncoso P, Thompson TC. Glioma Pathogenesis-Related Protein 1 Induces Prostate Cancer Cell Death through Hsc70-Mediated Suppression of AURKA and TPX2. Mol Oncol 7(3):484-96, 2013. e-Pub 2013. PMID: 23333597.
158. Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 123(5):2119-30, 2013. e-Pub 2013. PMID: 23585472.
159. Reichert M, Takano S, von Burstin J, Kim SB, Lee JS, Ihida-Stansbury K, Hahn C, Heeg S, Schneider G, Rhim AD, Stanger BZ, Rustgi AK. The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev 27(3):288-300, 2013. e-Pub 2013. PMID: 23355395.
160. Wong GS, Habibollahi P, Heidari P, Lee JS, Klein-Szanto AJ, Waldron TJ, Gimotty P, Nakagawa H, Taylor PR, Wang TC, Mahmood U, Rustgi AK. Optical Imaging of Periostin Enables Early Endoscopic Detection and Characterization of Esophageal Cancer in Mice. Gastroenterology 144(2):294-297, 2013. e-Pub 2013. PMID: 23085486.
161. Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, Wu S, Han HD, Shah MY, Rodriguez-Aguayo C, Bottsford-Miller J, Liu Y, Kim SB, Unruh A, Gonzalez-Villasana V, Huang L, Zand B, Moreno-Smith M, Mangala LS, Taylor M, Dalton HJ, Sehgal V, Wen Y, Kang Y, Baggerly KA, Lee JS, Ram PT, Ravoori MK, Kundra V, Zhang X, Ali-Fehmi R, Gonzalez-Angulo AM, Massion PP, Calin GA, Lopez-Berestein G, Zhang W, Sood AK. Tumour angiogenesis regulation by the miR-200 family. Nat Commun 4:2427, 2013. e-Pub 2013. PMID: 24018975.
162. Park YY, Lee SS, Lim JY, Kim SC, Kim SB, Sohn BH, Chu IS, Oh SC, Park ES, Jeong W, Kim SS, Kopetz S, Lee JS. Comparison of prognostic genomic predictors in colorectal cancer. PLoS One 8(4):e60778, 2013. e-Pub 2013. PMID: 23626670.
163. Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, Naora H. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest 122(10):3603-17, 2012. e-Pub 2012. PMID: 22945634.
164. Park YY, Jung SY, Jennings NB, Rodriguez-Aguayo C, Peng G, Lee SR, Kim SB, Kim K, Leem SH, Lin SY, Lopez-Berestein G, Sood AK, Lee JS. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis 33(10):1843-53, 2012. e-Pub 2012. PMID: 22581827.
165. Oh SC, Park YY, Park ES, Lim JY, Kim SM, Kim SB, Kim J, Kim SC, Chu IS, Smith JJ, Beauchamp RD, Yeatman TJ, Kopetz S, Lee JS. Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut 61(9):1291-8, 2012. e-Pub 2012. PMID: 21997556.
166. Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Mol Cancer Ther 11(9):1852-62, 2012. e-Pub 2012. PMID: 22752225.
167. Kim WY, Prudkin L, Feng L, Kim ES, Hennessy B, Lee JS, Lee JJ, Glisson B, Lippman SM, Wistuba II, Hong WK, Lee HY. Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors. Cancer 118(16):3993-4003, 2012. e-Pub 2012. PMID: 22359227.
168. Peng G, Dai H, Zhang W, Hsieh HJ, Pan MR, Park YY, Tsai RY, Bedrosian I, Lee JS, Ira G, Lin SY. Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection. Cancer Res 72(11):2802-13, 2012. e-Pub 2012. PMID: 22491672.
169. Frau M, Simile MM, Tomasi ML, Demartis MI, Daino L, Seddaiu MA, Brozzetti S, Feo CF, Massarelli G, Solinas G, Feo F, Lee JS, Pascale RM. An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis. Cell Oncol (Dordr) 35(3):163-73, 2012. e-Pub 2012. PMID: 22434528.
170. Kim YH, Liang H, Liu X, Lee JS, Cho JY, Cheong JH, Kim H, Li M, Downey TJ, Dyer MD, Sun Y, Sun J, Beasley EM, Chung HC, Noh SH, Weinstein JN, Liu CG, Powis G. AMPKα modulation in cancer progression: multilayer integrative transcriptome analysis in Asian gastric cancer. Cancer Res 72(10):2512-21, 2012. e-Pub 2012. PMID: 22434430.
171. Kim SJ, Lee JS, Kim SM. 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. Oncol Rep 27(5):1669-73, 2012. e-Pub 2012. PMID: 22293900.
172. Kim SM, Leem SH, Chu IS, Park YY, Kim SC, Kim SB, Park ES, Lim JY, Heo J, Kim YJ, Kim DG, Kaseb A, Park YN, Wang XW, Thorgeirsson SS, Lee JS. 65-gene-based risk score classifier predicts overall survival in hepatocellular carcinoma. Hepatology 55(5):1443-52, 2012. e-Pub 2012. PMID: 22105560.
173. Hildebrandt MA, Tan W, Tamboli P, Huang M, Ye Y, Lin J, Lee JS, Wood CG, Wu X. Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients. Carcinogenesis 33(4):799-803, 2012. e-Pub 2012. PMID: 22266464.
174. Cheng KW, Agarwal R, Mitra S, Lee JS, Carey M, Gray JW, Mills GB. Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med 4(2):125-41, 2012. e-Pub 2012. PMID: 22253197.
175. Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Identification of Oncogenic MicroRNA-17-92/ZBTB4/Specificity Protein Axis in Breast Cancer. Oncogene 31(8):1034-44, 2012. e-Pub 2012. PMID: 21765466.
176. Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Mol Med 4(1):52-67, 2012. e-Pub 2012. PMID: 22174013.
177. Park YY, Park ES, Kim SB, Kim SC, Sohn BH, Chu IS, Jeong W, Mills GB, Byers LA, Lee JS. Development and validation of a prognostic gene-expression signature for lung adenocarcinoma. PLoS One 7(9):e44225, 2012. e-Pub 2012. PMID: 22970185.
178. Lee JC, Kang SU, Jeon Y, Park JW, You JS, Ha SW, Bae N, Lubec G, Kwon SH, Lee JS, Cho EJ, Han JW. Protein L-isoaspartyl methyltransferase regulates p53 activity. Nat Commun 3:927, 2012. e-Pub 2012. PMID: 22735455.
179. Li L, Ren C, Yang G, Fattah EA, Goltsov AA, Kim SM, Lee JS, Park S, Demayo FJ, Ittmann MM, Troncoso P, Thompson TC. GLIPR1 suppresses prostate cancer development by targeted oncoprotein destruction. Cancer Res 71(24):7694-704, 2011. e-Pub 2011. PMID: 22025562.
180. Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, Wa Cheng K, Hall H, Zhang D, Lu Y, Ravoori M, Kundra V, Ajani J, Lee JS, Ki Hong W, Mills GB. Dual inhibition of Tumor Energy Pathway by 2-deoxy glucose and metformin Is Effective Against a Broad Spectrum of Preclinical Cancer Models. Mol Cancer Ther 10(12):2350-62, 2011. e-Pub 2011. PMID: 21992792.
181. Kim SJ, Chung MJ, Kim JS, Kim B, Park WH, Kim SH, Kim SZ, Lee JS, Kim SM. Deciphering the role of paclitaxel in the SKGT4 human esophageal adenocarcinoma cell line. Int J Oncol 39(6):1587-91, 2011. e-Pub 2011. PMID: 21935570.
182. Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN. ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. Cancer Res 71(22):7010-20, 2011. e-Pub 2011. PMID: 21937683.
183. Nick AM, Stone RL, Armaiz-Pena G, Ozpolat B, Tekedereli I, Graybill WS, Landen CN, Villares G, Vivas-Mejia P, Bottsford-Miller J, Kim HS, Lee JS, Kim SM, Baggerly KA, Ram PT, Deavers MT, Coleman RL, Lopez-Berestein G, Sood AK. Silencing of p130Cas in Ovarian Carcinoma: A Novel Mechanism for Tumor Cell Death. J Natl Cancer Inst 103(21):1596-612, 2011. e-Pub 2011. PMID: 21957230.
184. Kim SM, S-H L, I-S C, Y-Y P, S-C K, S-B K, E-S P, J-Y L, Heo J, Kim YJ, D-G K, Kaseb A, Park NY, Wang XW, Thorgeirsson SS, and Lee JS. 65-gene based risk score predicts overall survival in hepatocellular carcinoma. Hetatology, 2011. e-Pub 2011.
185. Iwamoto T, Lee JS, Bianchini G, Hubbard RE, Young E, Matsuoka J, Kim SB, Symmans WF, Hortobagyi GN, Pusztai L. First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations. Breast Cancer Res Treat 130(1):155-64, 2011. e-Pub 2011. PMID: 21833625.
186. Yang JD, Seol SY, Leem SH, Kim YH, Sun Z, Lee JS, Thorgeirsson SS, Chu IS, Roberts LR, Kang KJ. Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling. J Korean Med Sci 26(11):1428-38, 2011. e-Pub 2011. PMID: 22065898.
187. Park ES, Kim SJ, Kim SW, Yoon SL, Leem SH, Kim SB, Kim SM, Park YY, Cheong JH, Woo HG, Mills GB, Fidler IJ, Lee JS. Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis. Proc Natl Acad Sci U S A 108(42):17456-61, 2011. e-Pub 2011. PMID: 21987811.
188. Park ES, Kim SJ, Kim SW, S-L Y, S-H L, S-B K, Woo HG, Kim SM, Y-Y P, Cheong JH, Woo HG, Mills GB, Fidler IJ, Lee JS. Cross-species hybridization of microarray experiments revealed glabal reprogramming of transcriptome during brain metastasis. Pro Natl Acad Sci USA 108(42):17456-61, 2011. e-Pub 2011.
189. Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee JS, Tan SH, Wu J, Lee MH, Ooi CH, Rha SY, Wong WK, Boussioutas A, Yeoh KG, So J, Yong WP, Tsuburaya A, Grabsch H, Toh HC, Rozen S, Cheong JH, Noh SH, Wan WK, Ajani JA, Lee JS, Tellez MS, Tan P. Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy. Gastroenterology 141(2):476-85, 2011. e-Pub 2011. PMID: 21684283.
190. Guo L, Fan D, Zhang F, Price JE, Lee JS, Marchetti D, Fidler IJ, Langley RR. Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar. Am J Pathol 178(5):2357-66, 2011. e-Pub 2011. PMID: 21514446.
191. Cho JY, Lim JY, Cheong JH, Park YY, Yoon SL, Kim SM, Kim SB, Kim H, Hong SW, Park YN, Noh SH, Park ES, Chu IS, Hong WK, Ajani JA, Lee JS. Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res 17(7):1850-7, 2011. e-Pub 2011. PMID: 21447720.
192. Mitra S, Lee JS, Cantrell M, Van den Berg CL. c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8). J Biol Chem 286(17):15287-97, 2011. e-Pub 2011. PMID: 21357683.
193. Stairs DB, Bayne LJ, Rhoades B, Vega ME, Waldron TJ, Kalabis J, Klein-Szanto A, Lee JS, Katz JP, Diehl JA, Reynolds AB, Vonderheide RH, Rustgi AK. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 19(4):470-83, 2011. e-Pub 2011. PMID: 21481789.
194. Shahzad MM, Mangala LS, Han HD, Lu C, Bottsford-Miller J, Nishimura M, Mora EM, Lee JW, Stone RL, Pecot CV, Thanapprapasr D, Roh JW, Gaur P, Nair MP, Park YY, Sabnis N, Deavers MT, Lee JS, Ellis LM, Lopez-Berestein G, McConathy WJ, Prokai L, Lacko AG, Sood AK. Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles. Neoplasia 13(4):309-19, 2011. e-Pub 2011. PMID: 21472135.
195. Cascone T, Herynk MH, Xu L, Du Z, Kadara H, Nilsson MB, Oborn CJ, Park YY, Erez B, Jacoby JJ, Lee JS, Lin HY, Ciardiello F, Herbst RS, Langley RR, Heymach JV. Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma. J Clin Invest 121(4):1313-28, 2011. e-Pub 2011. PMID: 21436589.
196. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia 13(3):286-98, 2011. e-Pub 2011. PMID: 21390191.
197. Lee EK, Kim HJ, Lee KJ, Lee HJ, Lee JS, Kim DG, Hong SW, Yoon Y, Kim JS. Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling. Int J Oncol 38(2):325-33, 2011. e-Pub 2011. PMID: 21132267.
198. Yang JD, Sun Z, Hu C, Lai J, Dove R, Nakamura I, Lee JS, Thorgeirsson SS, Kang KJ, Chu IS, Roberts LR. Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. Genes Chromosomes Cancer 50(2):122-35, 2011. e-Pub 2011. PMID: 21104785.
199. King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, Rustgi AK. LIN28B Promotes Colon Cancer Progression and Metastasis. Cancer Res 71(12):4260-8, 2011. e-Pub 2011. PMID: 21512136.
200. Claerhout S, Lim JY, Choi W, Park YY, Kim K, Kim SB, Lee JS, Mills GB, Cho JY. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PLoS One 6(9):e24662, 2011. e-Pub 2011. PMID: 21931799.
201. Roessler S, Jia HL, Budhu A, Forgues M, Ye QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX, Wang XW. A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res 70(24):10202-12, 2010. e-Pub 2010. PMID: 21159642.
202. Park YY, Choi HS, Lee JS. Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer. Mol Cells 30(5):485-91, 2010. e-Pub 2010. PMID: 20853064.
203. Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18(2):185-97, 2010. e-Pub 2010. PMID: 20708159.
204. Michaylira CZ, Wong GS, Miller CG, Gutierrez CM, Nakagawa H, Hammond R, Klein-Szanto AJ, Lee JS, Kim SB, Herlyn M, Diehl JA, Gimotty P, Rustgi AK. Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. Cancer Res 70(13):5281-92, 2010. e-Pub 2010. PMID: 20516120.
205. Kadara H, Fujimoto J, Men T, Ye X, Lotan D, Lee JS, Lotan R. A Gprc5a tumor suppressor loss of expression signature is conserved, prevalent, and associated with survival in human lung adenocarcinomas. Neoplasia 12(6):499-505, 2010. e-Pub 2010. PMID: 20563252.
206. Lee JS, Leem SH, Lee SY, Kim SC, Park ES, Kim SB, Kim SK, Kim YJ, Kim WJ, Chu IS. Expression Signature of E2F1 and Its Associated Genes Predict Superficial to Invasive Progression of Bladder Tumors. J Clin Oncol 28(16):2660-7, 2010. e-Pub 2010. PMID: 20421545.
207. Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol Cancer Ther 9(2):257-67, 2010. e-Pub 2010. PMID: 20124458.
208. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 107(4):1437-42, 2010. e-Pub 2010. PMID: 20080689.
209. Jimenez RH, Lee JS, Francesconi M, Castellani G, Neretti N, Sanders JA, Sedivy J, Gruppuso PA. Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR). PLoS One 5(2):e9084, 2010. e-Pub 2010. PMID: 20140209.
210. Kim SM, Park YY, Park ES, Cho JY, Izzo JG, Zhang D, Kim SB, Lee JH, Bhutani MS, Swisher SG, Wu X, Coombes KR, Maru D, Wang KK, Buttar NS, Ajani JA, Lee JS. Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome. PLoS One 5(11):e15074, 2010. e-Pub 2010. PMID: 21152079.
211. Zimonjic DB, Zhou X, Lee JS, Ullmannova-Benson V, Tripathi V, Thorgeirsson SS, Popescu NC. Acquired genetic and functional alterations associated with transforming growth factor β type I resistance in Hep3B human hepatocellular carcinoma cell line. J Cell Mol Med 13(9B):3985-92, 2009. e-Pub 2009. PMID: 19426152.
212. Agarwal R, Gonzalez-Angulo AM, Myhre S, Carey M, Lee JS, Overgaard J, Alsner J, Stemke-Hale K, Lluch A, Neve RM, Kuo WL, Sorlie T, Sahin A, Valero V, Keyomarsi K, Gray JW, Borresen-Dale AL, Mills GB, Hennessy BT. Integrative analysis of cyclin protein levels identifies cyclin B1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res 15(11):3654-3662, 2009. e-Pub 2009. PMID: 19470724.
213. Woo HG, Park ES, Lee JS, Lee YH, Ishikawa T, Kim YJ, Thorgeirsson SS. Identification of potential driver genes in human liver carcinoma by genome-wide screening. Cancer Res 69(9):4059-4066, 2009. e-Pub 2009. PMID: 19366792.
214. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, Fridlyand J, Sahin A, Agarwal R, Joy C, Liu W, Stivers D, Baggerly K, Carey M, Lluch A, Monteagudo C, He X, Weigman V, Fan C, Palazzo J, Hortobagyi GN, Nolden LK, Wang NJ, Valero V, Gray JW, Perou CM, Mills GB. Characterization of a naturally occurring breast cancer subset enriched in EMT and stem cell characteristics. Cancer Res 69(10):4116-4123, 2009. e-Pub 2009. PMID: 19435916.
215. Izzo JG, Wu X, Wu TT, Huang P, Lee JS, Liao Z, Lee JH, Bhutani MS, Hofstetter W, Maru D, Hung MC, Ajani JA. Therapy-induced Expression of NF-kB Portends Poor Prognosis in Patients with Localized Esophageal Cancer Undergoing Preoperative Chemoradiation. Dis Esophagus 22(2):127-132, 2009. e-Pub 2009. PMID: 19021681.
216. Jimenez RH, Boylan JM, Lee JS, Francesconi M, Castellani G, Sanders JA, Gruppuso PA. Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines. PLoS One 4(10):e7373, 2009. e-Pub 2009. PMID: 19816606.
217. Woo HG, Park ES, Cheon JH, Kim JH, Lee JS, Park BJ, Kim W, Park SC, Chung YJ, Kim BG, Yoon JH, Lee HS, Kim CY, Yi NJ, Suh KS, Lee KU, Chu IS, Roskams T, Thorgeirsson SS, Kim YJ. Gene expression based recurrence prediction of HBV-related human hepatocellular carcinoma. Clin. Cancer Res 14(7):2056-2064, 2008. e-Pub 2008.
218. Yoon, HY, Lee JS, Randazzo, PA. ARAP1 regulates endocytosis of EGFR. Traffic 9:2236-2252, 2008. e-Pub 2008.
219. Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK, Guerrero RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Ahire AM, Nagorney DM, Sanderson SO, Adjei AA, Lee JS, Thorgeirsson SS, Roberts LR. Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma. Hepatology 47(4):1211-1222, 2008. e-Pub 2008.
220. Kremer-Tal S, Narla G, Chen Y, Hod E, DiFeo A, Yea S, Lee JS, Schwartz M, Thung SW, Fiel MI, Banck M, Zimran E, Thorgeirsson SS, Mazzaferro V, Bruix J, Martignetti JA, Llovet JM, and Friedman SL. Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J of Hepatology 2(1):e145, 2007. e-Pub 2007.
221. Park ES, Lee JS, Woo HG, Zhan F, Shih JH, Shaughnessy JD, and Mushinski JF. Heterologous Tissue Culture Expression Signature Predicts Human Breast Cancer Prognosis. PLos ONE 2(1):e145, 2007. e-Pub 2007.
222. Calvisi, DF, Ladu S, Gorden A, Farina M, Conner EA, Lee JS, Schroeder I, Sanchez A, Factor VM Thorgeirsson SS. Molecular pathogenesis of human hepatocellular carcinoma: mechanistic and prognostic significance of aberrant methylation. J of Clinical Investigation 117(9):2713-2722, 2007. e-Pub 2007.
223. Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, Srinivasan SV, Boivin GP, Lee JS, Aronow BJ, Thorgeirsson SS, Knudsen ES. RB loss enhances liver tumorigenesis by compromising genome integrity. Gastroenterology 133(3):976-984, 2007. e-Pub 2007.
224. Park ES, Shaughnessy JD, Gupta S, Wang H, Lee JS, Woo HG, Zhang F, Owens JD, Potter M, Janz S, Mushiniski JF. Gene expression profiles of m ouse plasma cell and B-Cell lymphomas reflect neoplastic contributions from Myc, Abl and IL-6 transgenes but not site of Myc activating chromosome translocation. BMC Genomics 8(1):302, 2007. e-Pub 2007.
225. Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 12(4):410-6, 2006. e-Pub 2006. PMID: 16532004.
226. Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouran C, Factor VM Thorgeirsson SS. Hepatocyte growthfactor/c-Met expression signature defines a subgroup of human hepatocellular carcinoma with poor prognosis and aggressive phenotype. J of Clinical Investigation 116(6):1582-1595, 2006. e-Pub 2006.
227. Lee JS, Kim IH, and Kim SY. Changes in gene expression with increased transglutamase 2 in a SH-SY5Y cell line. Frontiers in Bioscience 11:2774-2781, 2006. e-Pub 2006.
228. Coulouarn C, Gomez-Quiroz LE, Lee JS, Kaposi-Novak P, Conner EA, Goldina TA, Onishchenko GE, Factor VM, and Thorgeirsson SS. Targeted over-expression of E2f1 and Myc to the liver promotes neoplastic transformation by distinct mechanisms. Hepatology 44(4):1003-1011, 2006. e-Pub 2006.
229. Martin J, Magnino F, Schmidt K, A-C P, Lee, JS, Semela D, M-V S, Ziemiecki A, Cassio D, Brenner C, Mochly-Rosen D, Thorgeirsson SS, J-F AD. Hint2, a mitochondrial apoptotic sensitizer downregulated in hepatocellular carcinoma. Gastroenterology 130(7):2179-2188, 2006. e-Pub 2006.
230. Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouran C, Factor VM, and Thorgeirsson SS. Hint2, a mitochondrial apoptotic sensitizer downregulated in hepatocellular carcinoma. J of Clinical Investigation 116(6):1582-1595, 2006. e-Pub 2006.
231. Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouran C, Factor VM, and Thorgeirsson SS. Ubiquitous activation of Ras and Jak/Stat pathways in human HCCs. Gastroenterology 130(4):1117-1128, 2006. e-Pub 2006.
232. Heo J, Factor VM, Uren T, Takahama Y, Lee JS, Major M, Feinstone SM, and Thorgeirsson SS. Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver. Hepatology 44(6):1478-1486, 2006. e-Pub 2006.
233. Heo J, Lee JS, Chu IS, Takahama Y, Thorgeirsson SS. Spontaneous differentiation of mouse embryonic stem cells in vitro: Characterization by global gene expression profiles. Biochem Biophys Res Commun 332(4):1061-1069, 2005. e-Pub 2005. PMID: 15922302.
234. Karlsson G, Liu Y, Larsson J, Goumans MJ, Lee JS, Thorgeirsson SS, Ringnér M, Karlsson S. Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling. Physiol Genomics 21(3):396-403, 2005. e-Pub 2005. PMID: 15769904.
235. Lee JS, Thorgeirsson SS. Genetic profiling of human hepatocellular carcinoma. Semin Liver Dis 25(2):125-132, 2005. e-Pub 2005. PMID: 15918141.
236. Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, Thorgeirsson SS. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 36(12):1306-1311, 2004. e-Pub 2004. PMID: 15565109.
237. Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, Durnez A, Demetris AJ, Thorgeirsson SS. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 40(3):667-76, 2004. e-Pub 2004. PMID: 15349906.
238. Jeon GA, Lee JS, Patel V, Gutkind JS, Thorgeirsson SS, Kim EC, Chu IS, and Park M. Global gene expression profiles of human head and neck squamous carcinoma cells. Int J Cancer 112(2):249-258, 2004. e-Pub 2004.
239. Lee JS and Thorgeirsson SS. Genome-scale profiling of gene expression in hepatocellular carcinoma: Classification, survival prediction, and identification of therapeutic targets. Gastroenterology 127(5):S51-55, 2004. e-Pub 2004.
240. Kaposi-Novak P, Lee JS, Mikaelyan A, Patel V, and Thorgeirsson SS. Oligonucleotide microarray analysis of aminoallyl labeled cDNA targets from linear RNA amplification. Biotechniques 37(4):580-588, 2004. e-Pub 2004.
241. Meyer K, Lee JS, Dyck PA, Cao WQ, Rao MS, Thorgeirsson SS, and Reddy JK. Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-coA oxidase deficient mice: comparison with liver tumors Induced in wild type mice by a peroxisome proliferator and a genotoxic carcinogen. Carcinogenesis 24(5):975-984, 2003. e-Pub 2003.
242. Lee JS, Thorgeirsson SS. Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer. Hepatology 35(5):1134-1143, 2002. e-Pub 2002.
243. Lee J-S and Burr JG. Salpalpha and Salpbeta, growth-arresting homologs of Sam68. Gene 240(1):133-147, 1999. e-Pub 1999. PMID: 10564820.

Invited Articles

1. Yim SY, Lee JS. Genomic Perspective on Mouse Liver Cancer Models. Cancers (Basel) 11(11), 2019. e-Pub 2019. PMID: 31731480.
2. Lee JS. Exploring cancer genomic data from The Cancer Genome Atlas Project. BMB Rep 49(11):607-611, 2016. e-Pub 2016. PMID: 27530686.
3. Lee JS. The mutational landscape of hepatocellular carcinoma. Clin Mol Hepatol 21(3):220-9, 2015. e-Pub 2015. PMID: 26523267.
4. Park YY, Lee JS. In silico analysis of genomic data for construction of nuclear receptor network. Methods Mol Biol 1204:71-81, 2014. e-Pub 2014. PMID: 25182762.
5. Lee JS. Genomic profiling of liver cancer. Genomics Inform 11(4):180-5, 2013. e-Pub 2013. PMID: 24465228.
6. Wadhwa R, Song S, Lee JS, Yao Y, Wei Q, Ajani JA. Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol 10(11):643-55, 2013. e-Pub 2013. PMID: 24061039.
7. Lee JS, Kim JH, Park YY, Mills GB. Systems Biology Approaches to Decoding the Genome of Liver Cancer. Cancer Res Treat 43(4):205-211, 2011. e-Pub 2011. PMID: 22247704.
8. Ajani JA, Izzo JG, Lee JS. Chemotherapy and radiotherapy resistance: complexity, reality, and promise. J Clin Oncol 27(1):162-163, 2009. e-Pub 2009. PMID: 19047300.
9. Lee JS. Decoding Human Liver Cancer Signatures. Gastrointest Cancer Res 2(4.S2):S31-S34, 2008. e-Pub 2008. PMID: 19343146.
10. Lee JS, Thorgeirsson SS. Comparative and integrative functional genomics of HCC. Oncogene 25(27):3801-3809, 2006. e-Pub 2006. PMID: 16799621.
11. Thorgeirsson SS, Lee JS Grisham JW. Molecular prognostication of liver cancer; end of the beginning. J Hepatology 44(4):798-805, 2006. e-Pub 2006.
12. Thorgeirsson SS, J-S L, and Grisham JW. Functional genomics of hepatocellular carcinoma. Hepatology 43(2):S145-S150, 2006. e-Pub 2006. PMID: 16447291.
13. Lee JS, Grisham JW, Thorgeirsson SS. Comparative functional genomics for identifying models of human cancer. Carcinogenesis 26(6):1013-20, 2005. e-Pub 2005. PMID: 15677630.
14. J-S L, Thorgeirsson SS. Genetic profiling of human hepatocellular carcinoma. Seminars in Liver Disease 25(2):125-33, 2005. e-Pub 2005. PMID: 15918141.

Other Articles

1. Kim, KH, Chadalapaka, G, Lee, SO, Yamada, D, Sastre-Garau, X, Defossez, PA, Park, YY, Lee, J, Safe, S Editorial Expression of Concern. Oncogene 44(15):1064, 2025. PMID: 40169919.
2. Lee, SH, Park, J, Cho, HJ, Kang, I, Choi, SH, Lee, SS, Lee, JS Unsupervised clustering of multi-omics molecular layers reveals consensus molecular subtypes showing potential therapeutic opportunities for pancreatic cancer. Annals of Hepato-Biliary-Pancreatic Surgery 25:S43, 2021.
3. Cho, HJ, Kang, I, Choi, SH, Lee, SS, Lee, J, Lee, SH Precision strategy based on cancer-specific molecular subtypes of bile duct cancer from comprehensive analysis using multi-omics dataset. Annals of Hepato-Biliary-Pancreatic Surgery 25:S83, 2021.

Editorials

1. Xu M, Lee J. Multi-omics and machine learning in cholangiocarcinoma: A paradigm shift toward molecular subtyping and precision therapy. Hepatology, 2025. PMID: 41037731.
2. Lee SH, Yim SY, Kim JH, Lee SS, Kaseb AO, Lee JS. Correspondence on Letter regarding "Transcriptomic signature in advanced hepatocellular carcinoma tissue to predict combination immunotherapy response.". Clin Mol Hepatol, 2024. PMID: 39370716.
3. Lee SH, Yim SY, Kim JH, Lee SS, Kaseb AO, Wei P, Lee JS. Correspondence on Letter regarding "Comprehensive Analysis of Transcriptomic Biomarkers for Predicting Response to Atezolizumab Plus Bevacizumab Immunotherapy in Hepatocellular Carcinoma.". Clin Mol Hepatol 31(1):e110-e112, 2024. PMID: 39355874.
4. Yim SY, Lee SY, Kim JH, Lee SS, Kaseb AO, Lee JS. Correspondence on Letter regarding "Personalized Approaches to the Treatment of Hepatocellular Carcinoma Using Immune Checkpoint Inhibitors". Clin Mol Hepatol 31(1):e84-e86, 2024. PMID: 39370715.
5. Roh, JW, Huang, J, Hu, W, Yang, X, Jennings, NB, Sehgal, V, Sohn, BH, Han, HD, Lee, SJ, Thanapprapasr, D, Bottsford-Miller, J, Zand, B, Dalton, HJ, Previs, RA, Davis, AN, Matsuo, K, Lee, JS, Ram, P, Coleman, R, Sood, AK. Editor’s note: Biologic Effects of Platelet-Derived Growth Factor Receptor α Blockade in Uterine Cancer. Clinical Cancer Research 27(15):4449-4450, 2021. PMID: 34341054.

Book Chapters

1. Yim, SY, Shim, JJ, Sohn, BH, Lee, J. Experimental models of liver cancer. In: The LIVER: Biology and Pathology. 6th. Wiley, 749-757, 2020.
2. Lee SW, Yim SY, Shim JJ, J-S AL. Molecular subtypes and genomic signature of hepatocellular carcinoma for prognostication and therapeutic decision-making. In: Hepatocellular Carcinoma: Translational Precision Medicine Approaches. Humana Press, 2019.
3. J-H Shim, J-S Lee. Genome-based personalized medicine in liver cancer. In: Cancer Genetics and Genomics for Personalized Medicine. 1. San Stanford Publishing, 2017.
4. Park YY, Lee JS. In silico analysis of genomic data for construction of nuclear receptor network. In: Steroid Receptors: Methods and Protocols (Methods in Molecular Biology). Humana Press, 2014.
5. J-S Lee. Decoding HCC Signatures. In: The Liver: Biology and Pathology. 5th. Wiley, 1216, 2010.

Letters to the Editor

1. Yim, SY, Lee, J. Reply: Consensus subtypes of HCC associated with clinical outcomes and genomic phenotypes. Hepatology 78: E44, 2023.