Juan Fueyo, M.D., F.A.A.N., F.A.A.A.S.
Department of Neuro-Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Director of Special Operations, Department of Brain Tumor Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Tenure award, Department of Neuro-Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, Texas
Director of Neuro-Oncology Experimental Research, Department of Neuro-Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX
Research Interests
- Oncolytic adenoviruses
- Cell cycle/apoptosis
- Autophagy
- p16/Rb/E2F-1 pathway
- Molecular therapy
- Gliomas
- Cancer biology
My laboratory's projects primarily focus on the development of novel gene therapy strategies for the treatment of malignant gliomas. Specifically, I have been examining the mechanisms of cell- cycle control and cell death that are abrogated in brain tumors. Though working mostly on the P16/Rb (retinoblastoma)/E2F-1 pathway, we are also studying the role of p16, Rb, and E2F-1 as tumor suppressor genes in gliomas. In addition, I am in the process of determining whether conventional chemotherapeutics for gliomas can be enhanced when combined with gene therapy. Another related project involves the determination of proficient means of gene delivery using oncolytic viruses. In this regard, we have identified a replication-competent adenovirus (Delta- 24) that cannot bind the Rb protein, has a potent anticancer effect, and low toxicity in quiescent normal cells. The Delta-24 adenoviral construct is currently the target of a provisional patent and is being further realized into a future clinical trial for patients with malignant brain tumors. The focus of my laboratory over the next two years will be on improving the anticancer effect of oncolytic adenoviruses and the translation of those pre-clinical findings to the clinic setting.
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Education & Training
Degree-Granting Education
| 1997 | , Houston, Texas, US, Medicine, ECFMG diploma Medicine |
| 1984 | University Autonomous of Barcelona, Barcelona, ES, MD, Doctor in Medicine |
Postgraduate Training
| 1994-1997 | Research Fellowship, Experimental Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 1985-1992 | Clinical Residency, Neurology, University Autonomous of Barcelona, Barcelona |
Licenses & Certifications
| 1984 | Medicine and General Surgery |
Experience & Service
Editorial Activities
Associate Editor, Frontiers in Oncology, 2023 - Present
Member, Editorial Board, Molecular Therapy — Oncology, 2023 - Present
Member, Editorial Board, Molecular Therapy – Oncolytics, 2014 - 2023
Associate Editor, Autophagy, 2009 - 2018
Associate Editor, Neuro-Oncology, 2007 - 2012
Honors & Awards
| 2025 | Nomination - Potu N. Rao Award for Excellence in Basic Sciences, The University of Texas MD Anderson Cancer Center |
| 2025 | Commendation, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences |
| 2024 | The 2024 Golden Virus Award, International Oncolytic Virotherapy Consortium |
| 2023 - Present | Elected Honorary Member, Association of Spanish Scientists in U.S. (ECUSA) |
| 2022 | Nomination - McGovern Award for Outstanding Teaching, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences |
| 2022 - Present | Elected Fellow, Alliance for Cancer Gene Therapy (ACGT) |
| 2021 | NCI — Highlight in the National Cancer Act 50th Anniversary Commemoration: Cancer Research Starts Here: Accelerating Our Understanding of Cancer into the Future, National Cancer Institute |
| 2021 - Present | Elected Fellow, American Association for the Advancement of Science (AAAS) |
| 2019 - Present | Elected Fellow, American Academy of Neurology (AAN) |
| 2018 | Member, Spanish Selection of Science, Spanish National Research Council (CSIC) |
| 2016 | Nomination - Potu N. Rao Award for Excellence in Basic Science, Division of Cancer Medicine Faculty Recognition & Award Program, The University of Texas MD Anderson Cancer Center |
| 2016 | American Men and Women in Science |
| 2012 | Waun Ki Hong Award for Excellence Team Science [Delta-24 program], The University of Texas MD Anderson Cancer Center |
| 2009 | Nomination - Waun Ki Hong Award for Excellence Team Science [Delta-24 program], The University of Texas MD Anderson Cancer Center |
| 2003 | The Peter A. Steck Memorial Award, The Pediatric Brain Tumor Foundation of the United States of America |
| 2001 | American's Registry of Outstanding Professionals, Who's Who |
| 1997 | Best Presentation Award, European Neurological Society (ENS) |
| 1995 | Travel Award, American Association for Cancer Research (AACR) |
Selected Publications
Peer-Reviewed Articles
- Lopez-Rivas A, Gillard A, Fueyo J, Gomez-Manzano C. Implications of 9p21.3 deletion for glioma viroimmunotherapy. Neuro-Oncol. e-Pub 2026.
- Wu X, Ledbetter D, Tsai J, Singh S, Gumin J, Fan X, Gillard A, Shin DH, Jiang H, Zhao B, Ingram D, Akdmeir K, Conley A, Lazar A, Raza S, North R, Tatsui C, Lang F, Wang W, Rhines L, Gomez-Manzano C, Fueyo J, Alvarez-Breckenridge AC. Oncolytic Adenoviral Infection of Chordoma Achieves Treatment Efficacy through Immunogenic Cell Death and Tumor Microenvironment Alteration. Cancer Research. e-Pub 2025.
- Labiano, S, Marco-Sanz, J, Ausejo-Mauleon, I, Laspidea, V, Hernández-Osuna, R, Garcia Moure, M, Nava, Dl, Nuin, S, Gonzalez-Huarriz, M, Phoenix, T, Tamayo, I, Zalacain, M, Lacalle, A, Marrodan, L, Puigdelloses, M, Hervás-Corpión, I, Ochoa, MC, Casares, N, Becher, OJ, Gomez-Manzano, C, Fueyo-Margareto, J, Pérez-Larraya, JG, Patiño-García, A, Alonso, MM. Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas. Cell Reports Medicine 6(7), 2025. e-Pub 2025. PMID: 40578365.
- de la Nava D, Ausejo-Mauleon I, Laspidea V, Gonzalez-Huarriz M, Lacalle A, Casares N, Zalacain M, Marrodan L, García-Moure M, Ochoa MC, Tallon-Cobos AC, Hernandez-Osuna R, Marco-Sanz J, Dhandapani L, Hervás-Corpión I, Becher OJ, Nazarian J, Mueller S, Phoenix TN, van der Lugt J, Hernaez M, Guruceaga E, Koschmann C, Venneti S, Allen JE, Dun MD, Fueyo J, Gomez-Manzano C, Gállego Pérez-Larraya J, Patiño-García A, Labiano S, Alonso MM. The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models. Neuro-Oncology 26(8):1509-1525, 2024. e-Pub 2024. PMID: 38554031.
- Shin DH, Jiang H, Gillard AG, Kim D, Fan X, Singh SK, Nguyen TT, Sohoni SS, Lopez-Rivas AR, Parthasarathy A, Ene CI, Gumin J, Lang FF, Alonso MM, Gomez-Manzano C, Fueyo J. Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice. Mol Ther 32(3):722-733, 2024. e-Pub 2024. PMID: 38311852.
- Meléndez-Vázquez NM, Nguyen TT, Fan X, López-Rivas AR, Fueyo J, Gomez-Manzano C, Godoy-Vitorino F. Gut microbiota composition is associated with the efficacy of Delta-24-RGDOX in malignant gliomas. Mol Ther Oncol 32(1):200787, 2024. e-Pub 2024. PMID: 38596290.
- Kan P, Srinivasan VM, Gumin J, Garcia R, Chen SR, Johnson JN, Collins DE, Chen MM, Ledbetter D, Huse J, Evan Luna ZA, Robledo A, Vasandani V, Rao A, Singh SK, Shpall EJ, Fueyo J, Gomez-Manzano C, Lang FF. Development of a Rabbit Human Glioblastoma Model for Testing of Endovascular Selective Intra-Arterial Infusion (ESIA) of Novel Stem Cell-Based Therapeutics. Neuro Oncol 26(1):127-136, 2024. e-Pub 2024. PMID: 37603323.
- Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, Á L, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh G. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 29(6):1370-1378, 2023. e-Pub 2023. PMID: 37188783.
- Jiang H, Shin DH, Yi Y, Fan X, Gumin J, He J, Gillard AG, Lang FF, Gomez-Manzano C, Fueyo J. Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity. Cancer Res Commun 3(6):1118-1131, 2023. e-Pub 2023. PMID: 37379361.
- Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Alonso MM, Wainwright DA, Gomez-Manzano C, Fueyo J. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer 10(7), 2022. e-Pub 2022. PMID: 35902132.
- Gállego Pérez-Larraya J, Garcia-Moure M, Labiano S, Patiño-García A, Dobbs J, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, Puigdelloses M, Laspidea V, Astigarraga I, Lopez-Ibor B, Cruz O, Oscoz Lizarbe M, Hervas-Stubbs S, Alkorta-Aranburu G, Tamayo I, Tavira B, Hernandez-Alcoceba R, Jones C, Dharmadhikari G, Ruiz-Moreno C, Stunnenberg H, Hulleman E, van der Lugt J, MÁ I, Diez-Valle R, Esparragosa Vázquez I, Villalba M, de Andrea C, Núñez-Córdoba JM, Ewald B, Robbins J, Fueyo J, Gomez-Manzano C, Lang FF, Tejada S, Alonso MM. Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma. N Engl J Med 386(26):2471-2481, 2022. e-Pub 2022. PMID: 35767439.
- Laspidea V, Puigdelloses M, Labiano S, Marrodán L, Garcia-Moure M, Zalacain M, Gonzalez-Huarriz M, Martínez-Vélez N, Ausejo-Mauleon I, de la Nava D, Herrador-Cañete G, Marco-Sanz J, Guruceaga E, de Andrea CE, Villalba M, Becher O, Squatrito M, Matía V, Gállego Pérez-Larraya J, Patiño-García A, Gupta S, Gomez-Manzano C, Fueyo J, Alonso MM. Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas. JCI Insight 7(7), 2022. e-Pub 2022. PMID: 35393952.
- van Putten EHP, Kleijn A, van Beusechem VW, Noske D, Lamers CHJ, de Goede AL, Idema S, Hoefnagel D, Kloezeman JJ, Fueyo J, Lang FF, Teunissen CE, Vernhout RM, Bakker C, Gerritsen W, Curiel DT, Vulto A, Lamfers MLM, Dirven CMF. Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies. Clin Cancer Res 28(8):1572-1585, 2022. e-Pub 2022. PMID: 35176144.
- Shimizu Y, Gumin J, Gao F, Hossain A, Shpall EJ, Kondo A, Parker Kerrigan BC, Yang J, Ledbetter D, Fueyo J, Gomez-Manzano C, Lang FF. Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. J Neurosurg 136(3):1-11, 2022. e-Pub 2022. PMID: 34450587.
- Martinez-Velez N, Laspidea V, Zalacain M, Labiano S, García-Moure M, Puigdelloses M, Marrodan L, Gonzalez-Huarriz M, Herrador G, de la Nava D, Ausejo-Mauleon I, Fueyo J, Gomez-Manzano C, Patiño-García A, Alonso MM. Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory. Mol Cancer Ther 21(3):471-480, 2022. e-Pub 2022. PMID: 34965961.
- Phillips LM, Li S, Gumin J, Daou M, Ledbetter D, Yang J, Singh S, Parker Kerrigan BC, Hossain A, Yuan Y, Gomez-Manzano C, Fueyo J, Lang FF. An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus. Neuro Oncol 23(11):1911-1921, 2021. e-Pub 2021. PMID: 34059921.
- Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, Jiang H, Gomez-Manzano C, Fueyo J, Gállego Pérez-Larraya J, Alonso M. CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models. J Immunother Cancer 9(7), 2021. e-Pub 2021. PMID: 34281988.
- Garcia-Moure M, Gonzalez-Huarriz M, Labiano S, Guruceaga E, Bandres E, Zalacain M, Marrodan L, de Andrea C, Villalba M, Martinez-Velez N, Laspidea V, Puigdelloses M, Gallego Perez-Larraya J, Iñigo-Marco I, Stripecke R, Chan JA, Raabe EH, Kool M, Gomez-Manzano C, Fueyo J, Patiño-García A, Alonso MM. Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET. Clin Cancer Res 27(6):1807-1820, 2021. e-Pub 2021. PMID: 33376098.
- Srinivasan VM, Gumin J, Camstra KM, Collins DE, Chen MM, Shpall EJ, Parker Kerrigan BC, Johnson JN, Chen SR, Fueyo J, Gomez-Manzano C, Lang FF, Kan P. Endovascular Selective Intra-Arterial Infusion of Mesenchymal Stem Cells Loaded With Delta-24 in a Canine Model. Neurosurgery 88(1):E102-E113, 2020. e-Pub 2020. PMID: 33231254.
- de la Rocha AMA, González-Huarriz M, Guruceaga E, Mihelson N, Tejada-Solís S, Díez-Valle R, Martínez-Vélez N, Fueyo J, Gomez-Manzano C, Alonso MM, Laterra J, López-Bertoni H. miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs. Arch Clin Biomed Res 4(3):221-238, 2020. e-Pub 2020. PMID: 32905473.
- Jiang H, Shin DH, Nguyen TT, Fueyo J, Fan X, Henry V, Carrillo CC, Yi Y, Alonso MM, Collier TL, Yuan Y, Lang FF, Gomez-Manzano C. Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas. Clin Cancer Res 25(22):6801-6814, 2019. e-Pub 2019. PMID: 31455679.
- Rivera-Molina Y, Jiang H, Fueyo J, Nguyen T, Shin DH, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang FF, Gomez-Manzano C. GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory. Neurooncol Adv 1(1):vdz009, 2019. e-Pub 2019. PMID: 31608328.
- Martínez-Vélez N, Garcia-Moure M, Marigil M, González-Huarriz M, Puigdelloses M, Gallego Pérez-Larraya J, Zalacaín M, Marrodán L, Varela-Guruceaga M, Laspidea V, Aristu JJ, Ramos LI, Tejada-Solís S, Díez-Valle R, Jones C, Mackay A, Martínez-Climent JA, García-Barchino MJ, Raabe E, Monje M, Becher OJ, Junier MP, El-Habr EA, Chneiweiss H, Aldave G, Jiang H, Fueyo J, Patiño-García A, Gomez-Manzano C, Alonso MM. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. Nat Commun 10(1):2235, 2019. e-Pub 2019. PMID: 31138805.
- Martinez-Velez N, Marigil M, García-Moure M, Gonzalez-Huarriz M, Aristu JJ, Ramos-García LI, Tejada S, Díez-Valle R, Patiño-García A, Becher OJ, Gomez-Manzano C, Fueyo J, Alonso MM. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models. Acta Neuropathol Commun 7(1):64, 2019. e-Pub 2019. PMID: 31036068.
- Tejada S, Alonso M, Patiño A, Fueyo J, Gomez-Manzano C, Diez-Valle R. Phase I Trial of DNX-2401 for Diffuse Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients. Neurosurgery, 2018. e-Pub 2018. PMID: 29088386.
- Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J. Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma. J Clin Oncol 36(14):1419-1427, 2018. e-Pub 2018. PMID: 29432077.
- Lang FM, Hossain A, Gumin J, Momin EN, Shimizu Y, Ledbetter D, Shahar T, Yamashita S, Parker Kerrigan B, Fueyo J, Sawaya R, Lang FF. Mesenchymal Stem Cells as Natural Bio-Factories for Exosomes Carrying miR-124a in the Treatment of Gliomas. Neuro Oncol 20(3):380-390, 2018. e-Pub 2018. PMID: 29016843.
- Tejada S, Díez-Valle R, Domínguez PD, Patiño-García A, González-Huarriz M, Fueyo J, Gomez-Manzano C, Idoate MA, Peterkin J, Alonso MM. DNX-2401, an Oncolytic Virus, for the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Gliomas: A Case Report. Front Oncol 8:61, 2018. e-Pub 2018. PMID: 29594041.
- Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Puerta Martinez F, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Mol Cell Biol 37(21), 2017. e-Pub 2017. PMID: 28760776.
- Figueroa J, Phillips LM, Shahar T, Hossain A, Gumin J, Kim H, Bean AJ, Calin GA, Fueyo J, Walters ET, Kalluri R, Verhaak RG, Lang FF. Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587. Cancer Res 77(21):5808-5819, 2017. e-Pub 2017. PMID: 28855213.
- Jiang H, Rivera-Molina Y, Gomez-Manzano C, Clise-Dwyer K, Bover L, Vence LM, Yuan Y, Lang FF, Toniatti C, Hossain MB, Fueyo J. Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination. Cancer Res 77(14):3894-3907, 2017. e-Pub 2017. PMID: 28566332.
- Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo J, Lang FF, Fleming JB. Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 16(4):662-670, 2017. e-Pub 2017. PMID: 28138026.
- Xipell E, Aragón T, Martínez-Velez N, Vera B, Idoate MA, Martínez-Irujo JJ, Garzón AG, Gonzalez-Huarriz M, Acanda AM, Jones C, Lang FF, Fueyo J, Gomez-Manzano C, Alonso MM. Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro Oncol 18(8):1109-19, 2016. e-Pub 2016. PMID: 26951384.
- Xipell E, Gonzalez-Huarriz M, Martinez de Irujo JJ, García-Garzón A, Lang FF, Jiang H, Fueyo J, Gomez-Manzano C, Alonso MM. Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma. Oncotarget 7(21):30626-41, 2016. e-Pub 2016. PMID: 27121320.
- Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv 2(4):e1501290, 2016. e-Pub 2016. PMID: 27757426.
- Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano C. Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Oncotarget 7(13):16146-57, 2016. e-Pub 2016. PMID: 26910374.
- Klein SR, Jiang H, Hossain MB, Fan X, Gumin J, Dong A, Alonso MM, Gomez-Manzano C, Fueyo J. Critical role of autophagy in the processing of adenovirus capsid-incorporated cancer-specific antigens. PLoS One 11(4):e0153814, 2016. e-Pub 2016. PMID: 27093696.
- Acanda de la Rocha AM, López-Bertoni H, Guruceaga E, González-Huarriz M, Martínez-Vélez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MM. Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells. PLoS One 11(9):e0163155, 2016. e-Pub 2016. PMID: 27669421.
- Avci NG, Fan Y, Dragomir A, Akay YM, Gomez-Manzano C, Fueyo J, Akay M. Delta-24-RGD Induces Cytotoxicity of Glioblastoma Spheroids in Three Dimensional PEG Microwells. IEEE Trans Nanobioscience 14(8):946-51, 2015. e-Pub 2015. PMID: 26661633.
- Klein SR, Piya S, Lu Z, Xia Y, Alonso MM, White EJ, Wei J, Gomez-Manzano C, Jiang H, Fueyo J. C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy. Oncogene 34(41):5295-301, 2015. e-Pub 2015. PMID: 25619840.
- Gabrusiewicz K, Hossain MB, Cortes-Santiago N, Fan X, Kaminska B, Marini FC, Fueyo J, Gomez-Manzano C. Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model. Neoplasia 17(4):374-84, 2015. e-Pub 2015. PMID: 25925380.
- Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks J, Jacamo R, Kojima K, Ruvolo P, Fueyo J, Konopleva M, Andreeff M. MDM2 inhibitor, Nutlin 3a, induces p53 dependent autophagy in acute leukemia by AMP kinase activation. PLoS One 10(10):e0139254, 2015. e-Pub 2015. PMID: 26440941.
- Martinez-Velez N, Xipell E, Jauregui P, Zalacain M, Marrodan L, Zandueta C, Vera B, Urquiza L, Sierrasesúmaga L, Julián MS, Toledo G, Fueyo J, Gomez-Manzano C, Torre W, Lecanda F, Patiño-García A, Alonso MM. The Oncolytic Adenovirus Delta24-RGD in Combination with Cisplatin Exerts a Potent Anti-Osteosarcoma Activity. J Bone Miner Resi 29(10):2287-96, 2014. e-Pub 2014. PMID: 24737304.
- Gabrusiewicz K, Liu D, Cortes-Santiago N, Hossain MB, Conrad CA, Aldape KD, Fuller GN, Marini FC, Alonso MM, Idoate MA, Gilbert MR, Fueyo J, Gomez-Manzano C. Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes. Oncotarget 5(8):2208-20, 2014. e-Pub 2014. PMID: 24809734.
- Jiang H, Clise-Dwyer K, Ruisaard KE, Fan X, Tian W, Gumin J, Lamfers ML, Kleijn A, Lang FF, Yung WK, Vence LM, Gomez-Manzano C, Fueyo J. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS One 9(5):e97407, 2014. e-Pub 2014. PMID: 24827739.
- Martín V, Sanchez-Sanchez AM, Herrera F, Gomez-Manzano C, Fueyo J, Alvarez-Vega MA, Antolín I, Rodriguez C. Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells. Br J Cancer 108(10):2005-12, 2013. e-Pub 2013. PMID: 23632480.
- Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF. TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res 73(7):2333-44, 2013. e-Pub 2013. PMID: 23365134.
- Jiang H, White EJ, Ríos-Vicil CI, Xu J, Gomez-Manzano C, Fueyo J. Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity. J Virol 85(10):4720-9, 2011. e-Pub 2011. PMID: 21367888.
- Piya S, White EJ, Klein SR, Jiang H, McDonnell TJ, Gomez-Manzano C, Fueyo J. The E1B19K Oncoprotein Complexes with Beclin 1 to Regulate Autophagy in Adenovirus-Infected Cells. PLoS One 6(12):e29467, 2011. e-Pub 2011. PMID: 22242123.
- Liu D, Martin V, Fueyo J, Lee OH, Xu J, Cortes-Santiago N, Alonso MM, Aldape K, Colman H, Gomez-Manzano C. Tie2/TEK Modulates the Interaction of Glioma and Brain Tumor Stem Cells with Endothelial Cells and Promotes an Invasive Phenotype. Oncotarget 1(8):700-9, 2010. e-Pub 2010. PMID: 21321379.
- Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N, Fueyo J. The RB-E2F1 Pathway Regulates Autophagy. Cancer Res 70(20):7882-93, 2010. e-Pub 2010. PMID: 20807803.
- Dembinski JL, Spaeth EL, Fueyo J, Gomez-Manzano C, Studeny M, Andreeff M, Marini FC. Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells. Cancer Gene Ther 17(4):289-97, 2010. e-Pub 2010. PMID: 19876078.
- Yong RL, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus Delta-24-RGD to Human Gliomas. Cancer Res 69(23):8932-40, 2009. e-Pub 2009. PMID: 19920199.
- Martin V, Xu J, Pabbisetty SK, Alonso MM, Liu D, Lee OH, Gumin J, Bhat KP, Colman H, Lang FF, Fueyo J, Gomez-Manzano C. Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters. Oncogene 28(24):2358-63, 2009. e-Pub 2009. PMID: 19421150.
- Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther 16(3):256-65, 2009. e-Pub 2009. PMID: 18927600.
- Gomez-Manzano C, Holash J, Fueyo J, Xu J, Conrad CA, Aldape KD, de Groot JF, Bekele BN, Yung WK. VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol 10(6):940-5, 2008. e-Pub 2008. PMID: 18708344.
- Li JY, Wang H, May S, Song X, Fueyo J, Fuller GN, Wang H. Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas. J Neurooncol 88(1):11-7, 2008. e-Pub 2008. PMID: 18246408.
- Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-93, 2008. e-Pub 2008. PMID: 18253154.
- Lee OH, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, Jiang H, Piao Y, Liu TJ, Gomez-Manzano C. Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in glioma. Oncogene 27(9):1310-1314, 2008. e-Pub 2008. PMID: 17704802.
- Alonso MM, Gomez-Manzano C, Bekele BN, Yung WK, Fueyo J. Adenovirus-based strategies overcome temozolomide resistance by silencing the 06-methylguanine-DNA methyltransferase promoter. Cancer Res 67(24):11499-504, 2007. e-Pub 2007. PMID: 18089777.
- Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WK. Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res 67(22):11054-63, 2007. e-Pub 2007. PMID: 18006852.
- Cascallo M, Alonso MM, Rojas JJ, Perez-Gimenez A, Fueyo J, Alemany R. Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway. Mol Ther 15(9):1607-15, 2007. e-Pub 2007. PMID: 17579575.
- Alonso MM, Cascallo M, Gomez-Manzano C, Jiang H, Bekele BN, Perez-Gimenez A, Lang FF, Piao Y, Alemany R, Fueyo J. ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo. Cancer Res 67(17):8255-63, 2007. e-Pub 2007. PMID: 17804740.
- Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Knodo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99(18):1410-4, 2007. e-Pub 2007. PMID: 17848677.
- Alonso MM, Gomez-Manzano C, Jiang H, Bekele NB, Piao Y, Yung WK, Alemany R, Fueyo J. Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo. Cancer Gene Ther 14(8):756-761, 2007. e-Pub 2007. PMID: 17557108.
- Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WK, Gomez-Manzano C, Fueyo J. Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res 67(9):4005-4009, 2007. e-Pub 2007. PMID: 17483310.
- Jiang H, Olson MV, Medrano DR, Lee OH, Xu J, Piao Y, Alonso MM, Gomez-Manzano C, Hung MC, Yung WK, Fueyo J. A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. Faseb J 20:2603-5, 2006. e-Pub 2006. PMID: 17065226.
- Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM, Piao Y, Liu TJ, Lang FF, Bekele BN, Gomez-Manzano C. Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res 4:915-26, 2006. e-Pub 2006. PMID: 17189382.
- Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF, Bekele BN, Zhou X, Alonso MA, Aldape KD, Fuller GN, Gomez-Manzano C. Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 8(5):419-28, 2006. e-Pub 2006. PMID: 16790091.
- Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res 12(2):556-62, 2006. e-Pub 2006. PMID: 16428500.
- Guo W, Zhu H, Zhang L, Davis J, Teraishi F, Roth JA, Stephens C, Fueyo J, Jiang H, Conrad C, Fang B. Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models. Cancer Gene Ther 13(1):82-90, 2006. e-Pub 2006. PMID: 16037823.
- Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, Yung WK, Gomez-Manzano C. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst 97(21):1589-600, 2005. e-Pub 2005. PMID: 16264179.
- Jiang H, Alemany R, Gomez-Manzano C, Medrano DR, Lemoine MG, Olson MV, Alonso MM, Lee OH, Conrad CC, Yung WK, Fueyo J. Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses. Neoplasia 7(8):723-9, 2005. e-Pub 2005. PMID: 16207474.
- Conrad C, Miller CR, Ji Y, Gomez-Manzano C, Bharara S, McMurray JS, Lang FF, Wong F, Sawaya R, Yung WK, Fueyo J. Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization. Cancer Gene Ther 12(3):284-94, 2005. e-Pub 2005. PMID: 15650766.
- Jiang H, Gomez-Manzano C, Alemany R, Medrano D, Alonso M, Bekele BN, Lin E, Conrad CC, Yung WK, Fueyo J. Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas. Neoplasia 7(1):48-56, 2005. e-Pub 2005. PMID: 15720816.
- Stolarek R, Gomez-Manzano C, Jiang H, Suttle G, Lemoine MG, Fueyo J. Robust infectivity and replication of Delta-24 adenovirus induce cell death in human medulloblastoma. Cancer Gene Ther 11(11):713-20, 2004. e-Pub 2004. PMID: 15332115.
- Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Bekele BN, Yung WK, Fueyo J. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 23(10):1821-8, 2004. e-Pub 2004. PMID: 15014451.
- Arap MA, Lahdenranta J, Hajitou A, Marini FC, rd, Wood CG, Wright KC, Fueyo J, Arap W, Pasqualini R. Model of unidirectional transluminal gene transfer. Mol Ther 9(2):305-10, 2004. e-Pub 2004. PMID: 14759814.
- Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, Lemoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst 95(9):652-60, 2003. e-Pub 2003. PMID: 12734316.
- Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL, Jasti SL, Liu TJ, Conrad CA, Yung WK. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53(1):109-17, 2003. e-Pub 2003. PMID: 12509854.
- Mitlianga PG, Gomez-Manzano C, Kyritsis AP, Fueyo J. Overexpression of E2F-1 leads to bax-independent cell death in human glioma cells. Int J Oncol 21(5):1015-20, 2002. e-Pub 2002. PMID: 12370749.
- Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J, Alemany R, Fueyo J, Curiel DT, Vassal G, Pinedo HM, Vandertop WP, Gerritsen WR. Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy. Cancer Res 62(20):5736-42, 2002. e-Pub 2002. PMID: 12384532.
- Adachi Y, Chandrasekar N, Kin Y, Lakka SS, Mohanam S, Yanamandra N, Mohan PM, Fuller GN, Fang B, Fueyo J, Dinh DH, Olivero WC, Tamiya T, Ohmoto T, Kyritsis AP, Rao JS. Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences. Oncogene 21(1):87-95, 2002. e-Pub 2002. PMID: 11791179.
- Calbo J, Marotta M, Cascallo M, Roig JM, Gelpi JL, Fueyo J, Mazo A. Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer. Cancer Gene Ther 8(10):740-50, 2001. e-Pub 2001. PMID: 11687897.
- Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61(18):6693-7, 2001. e-Pub 2001. PMID: 11559537.
- Gomez-Manzano C, Lemoine MG, Hu M, He J, Mitlianga P, Liu TJ, Yung AW, Fueyo J, Groves MD. Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU. Int J Oncol 19(2):359-65, 2001. e-Pub 2001. PMID: 11445852.
- Im SA, Kim JS, Gomez-Manzano C, Fueyo J, Liu TJ, Cho MS, Seong CM, Lee SN, Hong YK, Yung WK. Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF. Br J Cancer 84(9):1252-7, 2001. e-Pub 2001. PMID: 11336478.
- Mitlianga PG, Kyritsis AP, Gomez-Manzano C, Lemoine MG, Hu M, Liu TJ, Yung WK, Fueyo J. Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells. Int J Oncol 18(2):343-7, 2001. e-Pub 2001. PMID: 11172602.
- Suzuki K, Fueyo J, Krasnykh V, Reynolds PN, Curiel DT, Alemany R. A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res 7(1):120-6, 2001. e-Pub 2001. PMID: 11205899.
- Fueyo J, Gomez-Manzano C, Alemany R, Lee PS, McDonnell TJ, Mitlianga P, Shi YX, Levin VA, Yung WK, Kyritsis AP. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 19(1):2-12, 2000. e-Pub 2000. PMID: 10644974.
- Im SA, Gomez-Manzano C, Fueyo J, Liu TJ, Ke LD, Kim JS, Lee HY, Steck PA, Kyritsis AP, Yung WK. Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo. Cancer Research 59(4):895-900, 1999. e-Pub 1999. PMID: 10029081.
- Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, McDonnell TJ, Shi X, Rao JS, Levin VA, Kyritsis AP. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 4(6):685-90, 1998. e-Pub 1998. PMID: 9623977.
- Ke LD, Fueyo J, Chen X, Steck PA, Shi YX, Im SA, Yung WK. A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes. Int J Oncol 12(6):1391-6, 1998. e-Pub 1998. PMID: 9592205.
- Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, Bruner JM, Chintala SK, Rao JS, Levin VA, Kyritsis AP. Suppression of human glioma growth by adenovirus-mediated Rb gene transfer. Neurology 50(5):1307-15, 1998. e-Pub 1998. PMID: 9595979.
- Fueyo J, Gomez-Manzano C, Puduvalli VK, Martin-Duque P, Perez-Soler R, Levin VA, Yung WK, Kyritsis AP. Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy. Int J Oncol 12(3):665-9, 1998. e-Pub 1998. PMID: 9472109.
- Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Bjerkvig R, Yung WK, Sawaya R, Kyritsis AP, Rao JS. Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 15(17):2049-57, 1997. e-Pub 1997. PMID: 9366522.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, McDonnell TJ, Steck PA, Levin VA, Yung WK. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J Natl Cancer Inst 89(14):1036-44, 1997. e-Pub 1997. PMID: 9230885.
- Fueyo J, Gomez-Manzano C, Bruner JM, Saito Y, Zhang B, Zhang W, Levin VA, Yung WK, Kyritsis AP. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas. Oncogene 13(8):1615-9, 1996. e-Pub 1996. PMID: 8895506.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnell TJ, Steck KD, Levin VA, Yung WK. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56(4):694-9, 1996. e-Pub 1996. PMID: 8630997.
- Fueyo J, Gomez-Manzano C, Yung WK, Clayman GL, Liu TJ, Bruner J, Levin VA, Kyritsis AP. Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12(1):103-10, 1996. e-Pub 1996. PMID: 8552379.
- Fueyo J, Gomez-Manzano C, Yung WK, Zhang W, Lee PS, Majumder S, Perhouse M, Levin VA, Kyritsis AP. A frequent polymorphism in exon 1 of the p16/CDKN2 gene. Mol Cell Probes 9(6):465-6, 1995. e-Pub 1995. PMID: 8808318.
- Group ES. Silent brain infartaction in nonrheumatic atrial fibrillation. Neurology 46:159-165, 1995. e-Pub 1995.
- Fueyo J, Ferrer I, Valldeoriola F, Graus F. The expression of a neuronal nuclear antigen (Ri) recognized by the human anti-Ri autoantibody in the developing rat nervous system. Neurosci Lett 162(1-2):141-4, 1993. e-Pub 1993. PMID: 8121617.
- Escudero D, Barnadas A, Codina M, Fueyo J, Graus F. Anti-Ri-associated paraneoplastic neurologic disorder without opsoclonus in a patient with breast cancer. Neurology 43(8):1605-6, 1993. e-Pub 1993. PMID: 8351021.
- Graus F, Rowe G, Fueyo J, Darnell RB, Dalmau J. The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons. Neurosci Lett 150(2):212-4, 1993. e-Pub 1993. PMID: 8469424.
- Group ES. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 342:1255-1262, 1993. e-Pub 1993.
- Study Group TEAFT. Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. N Engl J Med 333:5-10, 1993. e-Pub 1993.
- Pou Serradell A, Fueyo J, Gomez C, Oliveras C, Espadaler JM, Alameda F, Graus F. [Paraneoplastic encephalomyelitis and Lambert-Eaton syndrome]. Rev Neurol (Paris) 148(10):605-9, 1992. e-Pub 1992. PMID: 1338234.
- Ene C, Dr Singh SK, Venkataraman T, Phillips LM, Long JP, Singh D, Tran ND, Tufaro F, Anand PJ, Navin NE, Prabhu S, Weinberg JS, Larman B, Gomez-Manzano C, Fueyo J, Lang FF. Systemic immune correlates of long-term survival after Delta-24-RGD based on the Therapeutic Adenovirus for Recurrent Glioblastoma Effect Trial (TARGET). Clin Cancer Res.
- Meléndez-Vázquez NM, Wieren AV, Sohoni S, Bolaños-Rosero B, Fueyo J, Gomez-Manzano C, Godoy-Vitorino F. Immune-microbe responses to viroimmunotherapy against gastric cancer: a dynamic multi-kingdom approach. Cancer Discovery.
- Gomez-Manzano C, Alvarez-Beckeridge C, Shin DH, Guillard A, Alonso M, Lang F, Fueyo J. Diverse Origin and Nature of Tumor Infiltrating Lymphocytes: The Infection Hypothesis. Nature Cancer.
Book Chapters
- Martinez-Velez N, Gomez-Manzano C, Fueyo J, Patiño-Garcia A, Alonso MM. Oncolytic Virotherapy for Gliomas: A Preclinical and Clinical Summary. In: Gene Therapy in Neurological Disorders. 1st. Academic Press (Elsevier), 357-384, 2018.
- Xipell E, Rivera-Molina Y, Gomez-Manzano C, Jiang H, Alonso M, Alemany R, Fueyo J. Conditionally Replicative Adenoviruses- Clinical Trials. In: Adenoviral Vectors for Gene Therapy. 2nd. Elsevier, 335-348, 2016.
- Balvers RK, Gomez-Manzano C, Jiang H, Piya S, Klein SR, Lamfers MLM, Dirven CMF, Fueyo J. Advances in Oncolytic Virotherapy for Brain Tumors. In: Gene Therapy of Cancer. 3rd. Elsevier, 137-152, 2014.
- Gomez-Manzano C, Jiang H, Alonso M, Yung WK, Fueyo J. Gene Therapy. In: Handb Clin Neurol. 3rd. Elsevier, 331-8, 2012.
- Alonso MM, Jiang H, Gomez-Manzano C, Fueyo J. Targeting Brain Tumor Stem Cells with Oncolytic Adenoviruses. In: Methods Mol Biol. Springer Science & Humana Press, 111-25, 2012.
- Alonso M, Fueyo J, Gomez-Manzano C. Malignant Gliomas: Role of E2F1 Transcription Factor. In: Tumors of the Central Nervous System. Volume 1. Springer, 89-97, 2011.
- Jiang H, Fueyo J. Gene Therapy of Brain Tumors. In: Gene-based Therapies for Cancer. 1st. Springer Science + Business Media and Humana Press, 17-32, 2010.
- Jiang H, White EJ, Conrad C, Gomez-Manzano C, Fueyo J. Autophagy pathways in glioblastoma. In: Methods Enzymology: Autophagy in Disease and Clinical Applications. Part C. Academic Press, 273-86, 2009.
- Alonso MM, Fueyo J, Johnson DG, Gomez-Manzano C. The oncogenic role of E2F1 in brain tumors. In: Control of Cellular Physiology by E2F Transcription Factors. Research Signpost, 257-270, 2008.
- Alonso MM, Gomez-Manzano C, Alemany R, Jiang H, McCormick F, Fueyo J. Conditionally replicative adenoviruses as antitumoral agents: Past, present and future. In: Cancer and Gene Therapy. Transworld Research Network, 41-54, 2007.
- Jiang H, McCormick F, Gomez-Manzano C, Curiel DT, Lang FF, Yung WKA, Fueyo J. Replicating viruses for brain tumor treatment. In: Gene Therapy for Neurological Disorders. BC Decker Inc, 293-326, 2006.
- Fueyo J, Gomez-Manzano C, McDonnell TJ. Cell Cycle and Apoptosis in Human Brain Tumors. In: Human Brain Tumors. Humana Press Inc, 2005.
- Fueyo J, Gomez-Manzano C, McDonnell TJ. Regulation of Cell-Cycle and Apoptosis in Human Brain Tumors. In: Brain Tumors. In series: Contemporary Cancer Research. Part II. Humana Press Inc, 249-264, 2005.
- Stolarek R, Fueyo J, Gomez-Manzano C, Jiang H, Yung WKA. Gene-Based Therapy for Gliomas: Targeting the Cancer Genome. In: Genomic and Molecular Neuro-Oncology. Jones and Bartlett Publishers, Inc, 283-302, 2003.
- Gomez-Manzano C, Fueyo J, Yung WKA. Gene therapy approaches for gliomas. In: Brain Cancer. In series: American Cancer Society Atlas of Clinical Oncology. BC Decker, 219-237, 2001.
- Gomez-Manzano C, O-H L, Xu J, Fueyo J, Yung WKA. Neovascularization of malignant gliomas. In: Molecular Neuro-Oncology: Gliomas Methods and Protocols, In series: Methods in Molecular Medicine. Humana Press Inc, 2000.
- Gomez-Manzano C, Fueyo J, Kyritsis AP, Yung WKA. Tumor suppressor gene therapy for brain tumors. In: Gene Therapy for Neurological Disorders & Brain Tumors. Humana Press Inc, 205-230, 1998.
Patents
- Combination therapies using oncolytic adenovirus and immunomodulation. Patent Number: MDA13-050; Provisional App. No. 61/637,191; PCT/US2013/023304.
- Yung WKA, Gomez-Manzano C, Fueyo J, Cederbaum JM, Holash J. Use of VEGF Antagonists for the Treatment of Malignant Gliomas. Patent Number: Serial US 11/373,462/Patent 7,354,582.
Patient Reviews
CV information above last modified March 24, 2026