Julio Alcantara Montiel, MD, PhD, MS
Department of Hematopoietic Biology & Malignancy, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Instructor, Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2016 | National Polytechnic Institute (IPN), Center for Research and Advanced Studies (CINVESTAV), Mexico City, MX, Molecular Biomedicine, Ph.D |
| 2011 | National Polytechnic Institute (IPN), Center for Research and Advanced Studies (CINVESTAV), Mexico City, MX, Molecular Biomedicine, M.S |
| 2005 | Superior School of Medicine (ESM), National Polytechnic Institute, Mexico City, MX, MD |
Postgraduate Training
| 2006-2009 | Clinical Fellowship, Medical Genetics, National Institute of Medical Science and Nutrition “Salvador Zubirán” (INCMNSZ), Mexico City |
Experience & Service
Faculty Academic Appointments
Associate Professor C Full time, Department of Microbiology and Immunology, University National Autonomous of Mexico, Mexico City, Mexico city, 2016 - 2018
Other Professional Positions
Instructor of Genetics for Residents, Hospital Regional of High Specialization of Ixtapaluca HRAEI, Ixtapaluca, 2016 - 2018
Teacher in the faculty of Medicine, FES Zaragoza, University National Autonomous of Mexico, Mexico City, 2016 - 2018
Research Volunteer, National Institute of Allergy and Infectious Disease. Laboratory of Clinical Infectious Disease, Immunopathogenesis Section, Bethesda, MD, 2015 - 2015
Resident of Genetics, National Institute of Medical Sciences and Nutrition “Salvador Subirán” INCMNSZ, Mexico City, 2006 - 2009
Intramural Institutional Committee Activities
Reviewer, IMM program subcommittee Admissions UTHealth Houston, The University of Texas MD Anderson Cancer Center, 2025 - Present
Reviewer, Research Committee for the Medical Surgeon Degree, FES Zaragoza-University National Autonomous of Mexico, 2016 - 2018
Evaluator, Academic College of the Medical Surgeon Degree (COAC), FES Zaragoza-University National Autonomous of Mexico, 2016 - 2018
Member, Commission of Research at FES Zaragoza, University National Autonomous of Mexico, 2016 - 2017
Extramural Institutional Committee Activities
Reviewer, Ethics Committee for Research, Hospital Regional of High Specialization of Ixtapaluca HRAEI, 2017 - 2018
Honors & Awards
| 2017 - 2024 | National Research System SNI/CONACYT, CONACYT |
| 2011 | Scholarship for PhD degree, National Counsel of Science and Tech-CONACYT |
| 2011 - 2014 | Coordinate the Basic Genetics course, CINVESTAV-IPN |
| 2009 | Scholarship for Master of Science degree, National Counsel of Science and Tech-CONACYT |
| 2004 - 2005 | Award for Social Service Mexico City |
| 1999 - 2000 | Achievement Diploma in Medical Immunology |
| Rector's Certificate of Recognition, University National Autonomous of Mexico |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2017. Topics in Medical Genetics and Genomics. Invited. Ixtapaluca, State of Mexico, MX.
- 2017. Epigenetics and its Application in Health. Invited. Epidemiology and Public Health. Mexico City, Mexico city, MX.
- 2017. Study of Primary Immunodeficiencies. Invited. General Session. Ixtapaluca, State of Mexico, MX.
- 2017. Microbiota and Obesity. Invited. Research Seminar at FES Zaragoza. Mexico City, Mexico city, MX.
- 2016. Cellular Immunology,. Invited. Master’s Program in Biochemical Sciences. Mexico City, Mexico city, MX.
- 2016. Medical Genetics. Invited. Medical Genetics for Orthopedics and Gynecology Residents. Ixtapaluca, State of Mexico, MX.
- 2016. Characterization of mutations and functional activity in hyper IgE syndrome. Invited. Research Seminar at FES Zaragoza. Mexico City, Mexico city, MX.
- 2016. Basic Cellular and Molecular Mechanisms in Physiology, Microbiology, and Immunology. Invited. Mexico City, Mexico city, MX.
- 2016. Genetic Defects Causing Immunodeficiencies. Invited. 1st Congenital Defects Course. Mexico City, Mexico city, MX.
- 2014. Monoclonal Antibodies. Invited. 1st Clinical Immunology Course. Mexico City, Mexico city, MX.
- 2013. Application of flow cytometry in the diagnosis of primary immunodeficiency. Invited. Application of flow cytometry. Mexico City, Mexico city, MX.
- 2013. Intracellular signaling. Invited. symposium advances and perspectives flow cytometry. Mexico City, Mexico city, MX.
- 2013. Control of Gene Expression. Invited. Xalapa, Veracruz, MX.
- 2011. Molecular Genetics of immunoglobulins for master students of Immunology. Invited. Mexico City, Mexico city, MX.
- 2010. Human Pedigree. Invited. Specialty of Pediatric Allergy and Clinical Immunology. Mexico City, Mexico city, MX.
- 2010. Genetic counseling and inheritance. Invited. specialty of Pediatric Allergy and Clinical Immunology. Mexico City, Mexico city, MX.
Regional Presentations
- 2025. TCR and BCR Receptor with Long Reads Over 3’ Single Cell Kits. Poster. 6th Annual GCC Single Cell and Spatial- Omics Symposium, October 22, 2025. Houston, Texas, US.
National Presentations
- 2023. High-Throughput Identification of Graft-vs-Leukemia TCRs in AML Patient Samples After Allogeneic Stem Cell Transplantation. Poster. 65th ASH Annual Meeting. San Diego, CA, US.
- 2017. Determination of IgA and IgA2 in human colostrum and its association with the number of infections in the newborn. Poster. 18th International Congress of Mucosal Immunology. Washington, DC, DC, US.
- 2012. “Low phosphorylation of STAT-3 on interleukin-21 pathway in common variable immunodeficiency ”. Conference. 99th Annual meeting of the American Association of Immunologists 2012. Boston, MA, US.
International Presentations
- 2025. Transcriptional reprogramming and survival co-dependencies of chronic lymphocytic leukemia resistant to venetoclax. Poster. 30th EHA Congress. Milan, IT.
- 2025. Interrogating the Spatial Architecture of HLA-II Dysregulation in Relapsed AML Post-Hematopoietic Stem Cell Transplantation via Imaging Mass Cytometry. ISEH 54th Annual Scientific Meeting. Kumamoto, JP.
- 2018. “Higher levels of IgA1 and IgA2 in human colostrum are associated with number of infections during pregnancy”. Conference. XII Congress of the Latin American Association of Immunology. Cancun, MX.
- 2016. “Somatic mosaicism in B cells in patient with hyper IgE syndrome”. Conference. European Society For Immunodeficiencies. Barcelona, ES.
- 2014. “Functional characterization of Mexican patients with Hyper IgE syndrome”. Conference. Second Mexican meeting of primary immunodeficiencies. Guanajuato City, MX.
- 2014. “Two novel mutations in DNA Binding domain in patients with hyper IgE syndrome”. Conference. 16th Biennial Meeting of European Society For Immunodeficiencies. Prague, CZ.
- 2013. “Correlation of phosphorylation of STAT-3 and mutations by domains in patients with hyper IgE syndrome”. Conference. III LASID Meeting 2013. Santiago, CL.
- 2012. “Low phosphorylation of STAT-3 in patients with hyper IgE syndrome”. Conference. 15th Biennial meeting of the European Society for Immunodeficiencies. Florence, IT.
- 2012. “Correlation of Class-switched memory B cells and co-stimulatory molecules expression with clinical manifestations in patient with common variable immunodeficiency”. Conference. 15th Biennial meeting of the European Society for Immunodeficiencies. Florence, FR.
- 2011. “Phenotypic and functional analysis of B cells in patients with common variable immunodeficiency”. Conference. Second LASID meeting 2011. Mexico City, MX.
- 2011. “Is Interleukin-21 and its receptor one of the causes of common variable immunodeficiency? ”. Conference. Second LASID meeting 2011. Mexico City, MX.
- 2009. “ Molecular Characterization of PTCH gen in a patient with Gorlin syndrome”. Conference. XXXIV National Congress of Human Genetics. Tuxtla Gutiérrez, Chiapas, MX.
- 2008. "Descriptive studied of localization of bifida spine in a sample of 1,038 new born”. Conference. XXXIII National Congress of Human Genetics. Puerto Vallarta, MX.
- 2007. Two brothers with genetic variability of spectrum oculo-auriculo-vertebral”. Conference. XXXII National Congress of Human Genetics. Oaxaca, MX.
Grant & Contract Support
| Date: | 2017 - 2018 |
| Title: | Detection of immunoglobulin in human colostrum as screening for selective deficiency of IgA in mother and its correlation with infections in the newborn during the first trimester of life |
| Funding Source: | UNAM PAPIIT |
| Role: | PI |
| ID: | PAPIIT IA206117 |
| Date: | 2015 - 2017 |
| Title: | Analysis of functional defects in the IL21/STAT3 pathways in Mexican patients with Common Variable Immunodeficiency (CVID) |
| Funding Source: | CONACYT |
| Role: | Co-I |
| ID: | 2015-256471 |
| Date: | 2013 - 2014 |
| Title: | Characterization of mutations and functional activity of STAT-3 in patients with hyper IgE syndrome |
| Funding Source: | CONACYT |
| Role: | Co-I |
| ID: | Health 2013-01-02211 |
Selected Publications
Peer-Reviewed Articles
- Alonso-Bello CD, Jiménez-Martínez MDC, Vargas-Camaño ME, Hierro-Orozco S, Ynga-Durand MA, Berrón-Ruiz L, Alcántara-Montiel JC, Santos-Argumedo L, Andrea Herrera-Sánchez D, Lozano-Patiño F, Castrejón-Vázquez MI. Erratum to "Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome". Case Reports Immunol 2021:2361360, 2021. e-Pub 2021. PMID: 33628541.
- Sánchez-Salguero E, Mondragón-Ramírez GK, Alcántara-Montiel JC, Cérbulo-Vázquez A, Villegas-Domínguez X, Contreras-Vargas VM, Thompson-Bonilla MDR, Romero-Ramírez H, Santos-Argumedo L. Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum. Matern Health Neonatol Perinatol 5:9, 2019. e-Pub 2019. PMID: 31205733.
- Alonso-Bello CD, Jiménez-Martínez MDC, Vargas-Camaño ME, Hierro-Orozco S, Ynga-Durand MA, Berrón-Ruiz L, Alcántara-Montiel JC, Santos-Argumedo L, Herrera-Sánchez DA, Lozano-Patiño F, Castrejón-Vázquez MI. Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome. Case Reports Immunol 2019:6357256, 2019. e-Pub 2019. PMID: 31355024.
- Staines Boone AT, Alcántara-Montiel JC, Sánchez-Sánchez LM, Arce-Cano M, García-Campos J, Lugo Reyes SO. Zoledronate as effective treatment for minimal trauma fractures in a child with STAT3 deficiency and osteonecrosis of the hip. Pediatr Blood Cancer 63(11):2054-7, 2016. e-Pub 2016. PMID: 27416072.
- Alcántara-Montiel JC, Vega-Torres BI. [Hyper-IgE syndrome. Lessons from function and defects of STAT-3 or DOCK-8]. Rev Alerg Mex 63(4):385-396, 2016. e-Pub 2016. PMID: 27795219.
- Chandrasekaran P, Zimmerman O, Paulson M, Sampaio EP, Freeman AF, Sowerwine KJ, Hurt D, Alcántara-Montiel JC, Hsu AP, Holland SM. Distinct mutations at the same positions of STAT3 cause either loss or gain of function. J Allergy Clin Immunol 138(4):1222-1224.e2, 2016. e-Pub 2016. PMID: 27345172.
- Alcántara-Montiel JC, Staines-Boone T, López-Herrera G, Berrón-Ruiz L, Borrego-Montoya CR, Santos-Argumedo L. Somatic mosaicism in B cells of a patient with autosomal dominant hyper IgE syndrome. Eur J Immunol 46(10):2438-2443, 2016. e-Pub 2016. PMID: 27488252.
- Alcántara-Montiel JC, Staines-Boone T, López-Herrera G, Espinosa-Rosales F, Espinosa-Padilla SE, Hernández-Rivas R, Santos-Argumedo L. Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort. Clin Genet 89(2):217-21, 2016. e-Pub 2016. PMID: 26293184.
- Ramírez-Alejo N, Alcántara-Montiel JC, Yamazaki-Nakashimada M, Duran-McKinster C, Valenzuela-León P, Rivas-Larrauri F, Cedillo-Barrón L, Hernández-Rivas R, Santos-Argumedo L. Novel hypomorphic mutation in IKBKG impairs NEMO-ubiquitylation causing ectodermal dysplasia, immunodeficiency, incontinentia pigmenti, and immune thrombocytopenic purpura. Clin Immunol 160(2):163-71, 2015. e-Pub 2015. PMID: 26117626.
Book Chapters
- Alcántara-Montiel JC, Staines-Boone AT, Santos-Argumedo L. A Case-Based Collection with Multiple Choice Questions. In: Pediatric Allergy and Clinical Immunology. Springer, 743-746, 2019.
Patient Reviews
CV information above last modified March 27, 2026