Jun Yao, Ph.D.

Peer-Reviewed Articles

1. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. Expression of Concern for JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest 135(19), 2025. e-Pub 2025. PMID: 41031879.
2. Wei Y, Liu M, Yen EY, Yao J, Xun Z, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Li CF, Theardy MS, Park J, Cai Y, Takeda M, Vasquez M, Park EM, Peng DH, Zhou Y, Zhao H, Heffernan TP, Viale A, Wang H, Watowich SS, Liang H, Zhao D, DePinho RA, Yao W, Ying H. KRAS Inhibition Activates an Actionable CD24 "Don't Eat Me" Signal in Pancreatic Cancer. Cancer Res, 2025. e-Pub 2025. PMID: 40966362.
3. Theardy MS, Takeda M, Sorokin A, Chen S, Yang Z, Wang X, Kanikarla P, Coker O, Nguyen P, Wei Y, Yao J, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W. Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers. Cell Rep Med 6(8):102253, 2025. e-Pub 2025. PMID: 40713971.
4. Wang W, Cai Q, Liu Y, Nie L, Lee HH, Yan F, Fei Y, Yao Y, Li Y, Tan L, Lorenzi PL, Wang YN, Yao J, Chen Z, McIntosh J, Yu CT, Jain P, Jiang V, Vargas J, Li X, Zhang T, Li S, Santos D, Thirumurthi S, Seeley EH, Simon LM, Flowers CR, Ok CY, Wang ML. TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma. Blood, 2025. e-Pub 2025. PMID: 40700581.
5. Linghu, D, Song, J, Gu, L, Liu, C, Liu, B, Yang, R, Chen, Q, Yao, J, Manickam, SP, Sundhar, N, Tu, C, Chen, CH, Liu, Z, Liu, D, Chen, HF, Shi, S, Xiong, S, Hung, M, Sun, L. Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion. Journal for immunotherapy of cancer 13(7), 2025. e-Pub 2025. PMID: 40664443.
6. Chen MK, Yamaguchi H, Gao Y, Xia W, Chang JT, Hsiao YC, Shegute TW, Lin ZS, Wu CS, Wang YH, Litton JK, Ding Q, Wei Y, Chu YY, Meric-Bernstam F, Piwnica-Worms H, Arun B, Rodon Ahnert J, Liu J, Yao J, Chang WC, Wang HL, Tapia C, Albarracin CT, Keyomarsi K, Wang SC, Wang YN, Hortobagyi GN, Lin C, Yang L, Yu D, Hung MC. FGFR3-induced Y158 PARP1 phosphorylation promotes PARP inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models. J Clin Invest 135(14), 2025. e-Pub 2025. PMID: 40460005.
7. Zhao Z, Hu B, Deng Y, Soeung M, Yao J, Bei L, Zhang Y, Gong P, Huang LA, Jiang Z, Gao J, Peng S, Nguyen TK, Karki M, Lim B, Yee C, Burks JK, Zhang Q, Ma L, Gao J, Tannir NM, Han L, Yu D, Wang L, Curran MA, Gubbiotti MA, Genovese G, Gan B, Li W, Msaouel P, Yang L, Lin C. Sickle cell disease induces chromatin introversion and ferroptosis in CD8(+) T cells to suppress anti-tumor immunity. Immunity 58(6):1484-1501.e11, 2025. e-Pub 2025. PMID: 40359940.
8. Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B. Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance. Cancer Cell 43(6):1076-1092.e5, 2025. e-Pub 2025. PMID: 40215978.
9. Corvigno S, Yao J, Asare A, Zhao L, Celestino J, Hajek RA, Goette EAA, Rogers RT, Montoya RN, Song P, Zhang QC, Song X, Mohammad MM, Shaw KR, Zhang J, Lu KH, Jazaeri AA, Westin SN, Sood AK, Lee S. Longitudinal genomic profiling of chemotherapy-related CHIP variants in patients with ovarian cancer. Front Oncol 15:1538446, 2025. e-Pub 2025. PMID: 40365343.
10. Saito Y, Xiao Y, Yao J, Li Y, Liu W, Yuzhalin AE, Shyu YM, Li H, Yuan X, Li P, Zhang Q, Li Z, Wei Y, Yin X, Zhao J, Kariminia SM, Wu YC, Wang J, Yang J, Xia W, Sun Y, Jho EH, Chiao PJ, Hwang RF, Ying H, Wang H, Zhao Z, Maitra A, Hung MC, DePinho RA, Yu D. Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer. Cell Discov 10(1):109, 2024. e-Pub 2024. PMID: 39468013.
11. Yuzhalin AE, Lowery FJ, Saito Y, Yuan X, Yao J, Duan Y, Ding J, Acharya S, Zhang C, Fajardo A, Chen HN, Wei Y, Sun Y, Zhang L, Xiao Y, Li P, Lorenzi PL, Huse JT, Fan H, Zhao Z, Hung MC, Yu D. Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition. Nat Cell Biol 26(10):1773-1789, 2024. e-Pub 2024. PMID: 39304713.
12. Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov 14(8):1476-1495, 2024. e-Pub 2024. PMID: 38552003.
13. Fu J, Ling J, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y, Kang Y, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M, Huang Q, Yao J, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ, Huang P, Fleming JB, Maitra A, Tainer JA, Hung MC, Lin C, Chiao PJ. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun 15(1):3149, 2024. e-Pub 2024. PMID: 38605037.
14. Li, F, Wang, Y, Hwang, I, Jang, JY, Xu, L, Deng, Z, Yu, EY, Cai, Y, Wu, C, Han, Z, Huang, YH, Huang, X, Zhang, L, Yao, J, Lue, NF, Lieberman, PM, Ying, H, Paik, JH, Zheng, H. Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications 14(1), 2023. e-Pub 2023. PMID: 36991019.
15. Zhang, Y, Zhao, Z, Huang, L, Liu, Y, Yao, J, Sun, C, Li, Y, Zhang, Z, Ye, Y, Yuan, F, Nguyen, TK, Garlapati, NR, Wu, A, Egranov, SD, Caudle, AS, Sahin, AA, Lim, B, Beretta, L, Calin, GA, Yu, D, Hung, MC, Curran, M, Rezvani, K, Gan, B, Tan, Z, Han, L, Lin, C, Yang, L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metabolism 35(8):1457-1473.e13, 2023. e-Pub 2023. PMID: 37329887.
16. Zhang, X, Yao, J, Li, X, Niu, N, Liu, Y, Hajek, RA, Peng, G, Westin, SN, Sood, AK, Liu, J. Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Science Advances 9(29), 2023. e-Pub 2023. PMID: 37478190.
17. Shao, N, Zhou, Y, Yao, J, Zhang, P, Song, Y, Zhang, K, Han, X, Wang, B, Liu, X. A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration. Advanced Science 10(8), 2023. e-Pub 2023. PMID: 36658690.
18. Sun, C, Ye, Y, Tan, Z, Liu, Y, Li, Y, Hu, W, Liang, K, Egranov, SD, Huang, L, Zhang, Z, Zhang, Y, Yao, J, Nguyen, TK, Zhao, Z, Wu, A, Marks, JR, Caudle, AS, Sahin, AA, Gao, J, Gammon, ST, Piwnica-Worms, D, Hu, J, Chiao, PJ, Yu, D, Hung, MC, Curran, M, Calin, GA, Ying, H, Han, L, Lin, C, Yang, L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Science Advances 9(5), 2023. e-Pub 2023. PMID: 36724291.
19. Zhang X, Yao J, Niu N, Li X, Liu Y, Huo L, Euscher ED, Wang H, Bell D, Sood AK, Wang G, Lawson BC, Ramalingam P, Malpica A, Sahin AA, Ding Q, Liu J. SOX17: A Highly Sensitive and Specific Immunomarker for Ovarian and Endometrial Carcinomas. Mod Pathol 36(2):100001, 2023. e-Pub 2023. PMID: 36853778.
20. Jang, JY, Hwang, I, Pan, H, Yao, J, Alinari, L, Imada, E, Zanettini, C, Kluk, MJ, Wang, Y, Lee, Y, Lin, HV, Huang, X, Di Liberto, M, Chen, Z, Ballman, KV, Cantley, LC, Marchionni, L, Inghirami, G, Elemento, O, Baiocchi, R, Chen-Kiang, S, Belvedere, S, Zheng, H, Paik, JH. A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Journal of Clinical Investigation 132(24), 2022. e-Pub 2022. PMID: 36282572.
21. Zhang, L, Qu, J, Qi, Y, Duan, Y, Huang, YW, Zhou, Z, Li, P, Yao, J, Huang, B, Zhang, S, Yu, D. EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation. Nature communications 13(1), 2022. e-Pub 2022. PMID: 35538070.
22. Zhang, Y, Sun, C, Li, Y, Qin, J, Amancherla, K, Jing, Y, Hu, Q, Liang, K, Zhang, Z, Ye, Y, Huang, L, Nguyen, TK, Egranov, SD, Zhao, Z, Wu, A, Xi, Y, Yao, J, Hung, MC, Calin, GA, Cheng, J, Lim, B, Lehmann, LH, Salem, JE, Johnson, DB, Curran, M, Yu, D, Han, L, Darabi, R, Yang, L, Moslehi, JJ, Lin, C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Science translational medicine 14(669), 2022. e-Pub 2022. PMID: 36322628.
23. Handley, KF, Sims, TT, Bateman, NW, Glassman, D, Foster, KI, Lee, S, Yao, J, Yao, H, Fellman, B, Liu, J, Lu, Z, Conrads, KA, Hood, BL, Barakat, W, Zhao, L, Zhang, J, Westin, SN, Celestino, J, Rangel, KM, Badal, S, Pereira, I, Ram, P, Maxwell, GL, Eberlin, LS, Futreal, A, Bast Jr, RC, Fleming, N, Conrads, TP, Sood, AK. Classification of High-Grade Serous Ovarian Cancer Using Tumor Morphologic Characteristics. JAMA Network Open 5(10):E2236626, 2022. e-Pub 2022. PMID: 36239936.
24. Yuan, X, Duan, Y, Xiao, Y, Sun, K, Qi, Y, Zhang, Y, Ahmed, Z, Moiani, D, Yao, J, Li, H, Zhang, L, Yuzhalin, AE, Li, P, Zhang, C, Badu-Nkansah, A, Saito, Y, Liu, X, Kuo, WL, Ying, H, Sun, S, Chang, J, Tainer, J, Yu, D. Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer discovery 12(7):1743-1759, 2022. e-Pub 2022. PMID: 35420681.
25. Cha, JH, Chan, LC, Wang, Y, Chu, YY, Wang, CH, Lee, H, Xia, W, Shyu, WC, Liu, S, Yao, J, Chang, CW, Cheng, FR, Liu, J, Lim, S, Hsu, JL, Yang, W, Hortobagyi, GN, Lin, C, Yang, L, Yu, D, Jeng, LB, Hung, MC. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. Journal of Biological Chemistry 298(4), 2022. e-Pub 2022. PMID: 35278434.
26. Glassman D, Bateman NW, Lee S, Zhao L, Yao J, Tan Y, Ivan C, Rangel KM, Zhang J, Conrads KA, Hood BL, Abulez T, Futreal PA, Fleming ND, Afshar-Kharghan V, Maxwell GL, Conrads TP, Chen K, Sood AK. Molecular Correlates of Venous Thromboembolism (VTE) in Ovarian Cancer. Cancers (Basel) 14(6), 2022. e-Pub 2022. PMID: 35326647.
27. Li, H, Xiao, Y, Li, Q, Yao, J, Yuan, X, Zhang, Y, Yin, X, Saito, Y, Fan, H, Li, P, Kuo, WL, Halpin, A, Gibbons, DL, Yagita, H, Zhao, Z, Pang, D, Ren, G, Yee, C, Lee, JJ, Yu, D. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer cell 40(1):36-52.e9, 2022. e-Pub 2022. PMID: 34822775.
28. Lee, H, Wang, Y, Yang, W, Xia, W, Wei, Y, Chan, LC, Wang, YH, Jiang, Z, Xu, S, Yao, J, Qiu, YF, Hsu, Y, Hwang, WL, Yan, M, Cha, JH, Hsu, JL, Shen, J, Ye, Y, Wu, X, Hou, MF, Tseng, LM, Wang, SC, Pan, MR, Yang, CH, Wang, YL, Yamaguchi, H, Pang, D, Hortobagyi, GN, Yu, D, Hung, MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature communications 12(1), 2021. e-Pub 2021. PMID: 33986289.
29. Yang, R, Sun, L, Li, CF, Wang, YH, Yao, J, Li, H, Yan, M, Chang, W, Hsu, J, Cha, JH, Hsu, JL, Chou, CW, Sun, X, Deng, Y, Chou, C, Yu, D, Hung, MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nature communications 12(1), 2021. e-Pub 2021. PMID: 33547304.
30. Deng, Y, Xia, X, Zhao, Y, Zhao, Z, Martinez, C, Yin, W, Yao, J, Hang, Q, Wu, W, Zhang, J, Yu, Y, Xia, W, Yao, F, Zhao, D, Sun, Y, Ying, H, Hung, MC, Ma, L. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nature communications 12(1), 2021. e-Pub 2021. PMID: 34873175.
31. Niu N, Yao J, Bast RC, Sood AK, Liu J. IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming. Oncogenesis 10(9):65, 2021. e-Pub 2021. PMID: 34588424.
32. Wang, YL, Lee, CC, Shen, YC, Lin, PL, Wu, WR, Lin, YZ, Cheng, WC, Chang, H, Hung, Y, Cho, YC, Liu, L, Xia, W, Ji, JH, Liang, JA, Chiang, SF, Liu, C, Yao, J, Hung, MC, Wang, SC. Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Reports 36(8), 2021. e-Pub 2021. PMID: 34433039.
33. Li, Y, Tan, Z, Zhang, Y, Zhang, Z, Hu, Q, Liang, K, Yao, J, Ye, Y, Li, YC, Li, C, Liao, L, Xu, J, Xing, Z, Pan, Y, Chatterjee, SS, Nguyen, TK, Hsiao, H, Egranov, SD, Putluri, N, Coarfa, C, Hawke, DH, Gunaratne, PH, Tsai, KL, Han, L, Hung, MC, Calin, GA, Namour, F, Guéant, JL, Muntau, AC, Blau, N, Sutton, VR, Schiff, M, Feillet, F, Zhang, S, Lin, C, Yang, L. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science 373(6555):662-673, 2021. e-Pub 2021. PMID: 34353949.
34. Yan, L, Tu, B, Yao, J, Gong, J, Carugo, A, Bristow, C, Wang, Q, Zhu, C, Dai, B, Kang, Y, Han, L, Feng, N, Jin, Y, Fleming, JB, Heffernan, TP, Yao, W, Ying, H. Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition. Cancer Research 81(15):4054-4065, 2021. e-Pub 2021. PMID: 34117030.
35. Li, B, Pei, G, Yao, J, Ding, Q, Jia, P, Zhao, Z. Cell-type deconvolution analysis identifies cancer-associated myofibroblast component as a poor prognostic factor in multiple cancer types. Oncogene 40(28):4686-4694, 2021. e-Pub 2021. PMID: 34140640.
36. Jiang, Z, Lim, S, Yan, M, Hsu, JL, Yao, J, Wei, Y, Chang, S, Yamaguchi, H, Lee, H, Ke, B, Hsu, J, Chan, LC, Hortobagyi, GN, Yang, L, Lin, C, Yu, D, Hung, M. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. Journal of Clinical Investigation 131(8), 2021. e-Pub 2021. PMID: 33855973.
37. Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q. TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Mod Pathol 34(4):710-719, 2021. e-Pub 2021. PMID: 33011748.
38. Oh H, Hwang I, Jang JY, Wu L, Cao D, Yao J, Ying H, Li JY, Yao Y, Hu B, Wang Q, Zheng H, Paik J. Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling. Cancer Res 81(6):1528-1539, 2021. e-Pub 2021. PMID: 33509942.
39. Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell 80(6):1013-1024.e6, 2020. e-Pub 2020. PMID: 33338401.
40. Zhang L, Yao J, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S, Huse JT, Hung MC, Yu D. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Sci Transl Med 12(545), 2020. e-Pub 2020. PMID: 32461334.
41. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. CIC is a critical regulator of neuronal differentiation. JCI Insight 5(9), 2020. e-Pub 2020. PMID: 32229723.
42. Singh K, Pruski MA, Polireddy K, Jones NC, Chen Q, Yao J, Dar WA, McAllister F, Ju C, Eltzschig HK, Younes M, Moran C, Karmouty-Quintana H, Ying H, Bailey JM. Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer. Oncogene 39(5):1152-1164, 2020. e-Pub 2020. PMID: 31570790.
43. Han Y, Wei Y, Yao J, Chu YY, Li CW, Hsu JL, Nie L, Hung MC. Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERalpha expression in high-grade serous ovarian carcinoma. Am J Cancer Res 10(4):1194-1206, 2020. e-Pub 2020. PMID: 32368395.
44. Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun 10(1):5114, 2019. e-Pub 2019. PMID: 31704972.
45. Tu B, Yao J, Ferri-Borgogno S, Zhao J, Chen S, Wang Q, Yan L, Zhou X, Zhu C, Bang S, Chang Q, Bristow CA, Kang Y, Zheng H, Wang H, Fleming JB, Kim M, Heffernan TP, Draetta GF, Pan D, Maitra A, Yao W, Gupta S, Ying H. YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. JCI Insight 4(21), 2019. e-Pub 2019. PMID: 31557131.
46. Zhang P, Han X, Yao J, Shao N, Zhang K, Zhou Y, Zu Y, Wang B, Qin L. High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression. Angew Chem Int Ed Engl 58(39):13700-13705, 2019. e-Pub 2019. PMID: 31188523.
47. Ding L, Su Y, Fassl A, Hinohara K, Qiu X, Harper NW, Huh SJ, Bloushtain-Qimron N, Jovanovic B, Ekram M, Zi X, Hines WC, Aleckovic M, Gil Del Alcazar C, Caulfield RJ, Bonal DM, Nguyen QD, Merino VF, Choudhury S, Ethington G, Panos L, Grant M, Herlihy W, Au A, Rosson GD, Argani P, Richardson AL, Dillon D, Allred DC, Babski K, Kim EMH, McDonnell CH 3rd, Wagner J, Rowberry R, Bobolis K, Kleer CG, Hwang ES, Blum JL, Cristea S, Sicinski P, Fan R, Long HW, Sukumar S, Park SY, Garber JE, Bissell M, Yao J, Polyak K. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. Nat Commun 10(1):4182, 2019. e-Pub 2019. PMID: 31519911.
48. Acharya S, Yao J, Li P, Zhang C, Lowery FJ, Zhang Q, Guo H, Qu J, Yang F, Wistuba II, Piwnica-Worms H, Sahin AA, Yu D. Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer. Cancer Res 79(16):4211-4226, 2019. e-Pub 2019. PMID: 31239273.
49. Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol 20(7):835-851, 2019. e-Pub 2019. PMID: 31160797.
50. Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res 29(4):286-304, 2019. e-Pub 2019. PMID: 30631154.
51. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature 568(7752):410-414, 2019. e-Pub 2019. PMID: 30918400.
52. Guo H, Zeng D, Zhang H, Bell T, Yao J, Liu Y, Huang S, Li CJ, Lorence E, Zhou S, Gong T, Jiang C, Ahmed M, Yao Y, Nomie KJ, Zhang L, Wang M. Dual inhibition of PI3K signaling and histone deacetylation halts proliferation and induces lethality in mantle cell lymphoma. Oncogene 38(11):1802-1814, 2019. e-Pub 2019. PMID: 30361685.
53. Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell 33(2):187-201.e10, 2018. e-Pub 2018. PMID: 29438695.
54. Yamaguchi H, Du Y, Nakai K, Ding M, Chang SS, Hsu JL, Yao J, Wei Y, Nie L, Jiao S, Chang WC, Chen CH, Yu Y, Hortobagyi GN, Hung MC. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. Oncogene 37(2):208-217, 2018. e-Pub 2018. PMID: 28925391.
55. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest 127(12):4498-4515, 2017. e-Pub 2017. PMID: 29130936.
56. Wu X, Li X, Fu Q, Cao Q, Chen X, Wang M, Yu J, Long J, Yao J, Liu H, Wang D, Liao R, Dong C. AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program. J Exp Med 214(4):1065-1079, 2017. e-Pub 2017. PMID: 28270406.
57. Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P(3) to hyperactivate AKT and confer resistance to AKT inhibitors. Nat Cell Biol 19(3):238-251, 2017. e-Pub 2017. PMID: 28218907.
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Review Articles

1. Porter D, Yao J, Polyak K. SAGE and related approaches for cancer target identification. Drug Discovery Today 11(3-4):110-8, 2006. e-Pub 2006. PMID: 16533708.

Other Articles

1. Fu J, Koul D, Yao J, Wang S, Yuan Y, Colman H, Sulman EP, Lang FF, Yung WK Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells. Cancer Res 73(10):3062-74, 2013. PMID: 23492364.

Patents

1. Gan R, Huang P, Qian Y, Ling X, Zhang Q, Yao J, Ding H, Ding C. A novel system of using a chaperon for increasing protein secretion in Escherichia coli (E. coli). Patent Number: 98110840.7.