Jun Zou, M.D., PhD.
Department of Laboratory Medicine, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Medical Director, Department of Laboratory Medicine, Division of HLA Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Medical Director, Department of Pathology, Division of Tissue Antigen Laboratory, The University of Texas Medical Branch, Galveston, TX
Education & Training
Degree-Granting Education
| 2005 | University of Missouri at Columbia, Columbia, MO, USA, PHD, Biochemistry |
| 1999 | Peking University First Hospital, Peking University School of Medicine, Beijing, CHN, PHD, Anesthesiology |
| 1993 | Xian Jiaotong University School of Medicine [former name Xian Medical University], Xian, CHN, MD, Medicine |
Postgraduate Training
| 2014-2016 | Clinical Fellowship, Integrated HLA and Transfusion Medicine Fellowship, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis, MO |
| 2011-2014 | Clinical Residency, Department of Pathology and Immunology, Washington University School of Medicine / Barnes-Jewish Hospital, St. Louis, MO |
| 2005-2010 | Postdoctoral Fellow, Hematology Division, Internal Medicine Department, Washington University School of Medicine, St. Louis, MO |
| 1995-1999 | Clinical Residency, Department of Anesthesiology, Peking University First Hospital, Beijing |
| 1993-1995 | Clinical Residency, Department of General Surgery, Peking University Shougang Hospital, Beijing |
Board Certifications
| 2017 | American Board of Pathology, Blood Banking/Transfusion Medicine |
| 2016 | American Society for Histocompatibility & Immunogenetics |
| 2014 | American Board of Clinical Pathology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2022
Honors & Awards
| 2019 | Human Immunology, Best Paper of 2017 Award, American Society for Histocompatibility & Immunogenetics |
| 2015 | Young Investigator with Distinction Awards, 50th Annual Meeting of Academy of Clinical Laboratory Physician and Scientists |
| 2015 | Paul E. Strandjord Young Investigator Award, 50th Annual Meeting of Academy of Clinical Laboratory Physician and Scientists |
| 2005 | Margaret S.C. Cheng Fellowship, University of Missouri at Columbia |
| 1997 | Guang-Hua Award, Peking University School of Medicine |
Selected Publications
Peer-Reviewed Articles
- Zou J, Kongtim P, Oran B, Srour SA, Greenbaum U, Carmazzi Y, Rondon G, Ciurea SO, Ma Q, Shpall EJ, Champlin RE, Cao K. Molecular disparity of HLA-DPB1 is associated with the development of subsequent solid cancer after allogeneic hematopoietic stem cell transplantation. Cancer, 2023. e-Pub 2023. PMID: 36738229.
- Kim ST, Chu Y, Misoi M, Suarez-Almazor ME, Tayar JH, Lu H, Buni M, Kramer J, Rodriguez E, Hussain Z, Neelapu SS, Wang J, Shah AY, Tannir NM, Campbell MT, Gibbons DL, Cascone T, Lu C, Blumenschein GR, Altan M, Lim B, Valero V, Loghin ME, Tu J, Westin SN, Naing A, Garcia-Manero G, Abdel-Wahab N, Tawbi HA, Hwu P, Oliva ICG, Davies MA, Patel SP, Zou J, Futreal A, Diab A, Wang L, Nurieva R. Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy. Nat Commun 13(1):1970, 2022. e-Pub 2022. PMID: 35413951.
- Zou J, Kongtim P, Oran B, Kosmoliaptsis V, Carmazzi Y, Ma J, Li L, Rondon G, Srour S, Copley HC, Partlow D, Ciurea S, Greenbaum U, Saliba RM, Ma Q, Shpall E, Champlin RE, Cao K. Refined HLA-DPB1 mismatch permissiveness with molecular algorithms predicts outcomes in allogeneic hematopoietic stem cell transplantation. Haematologica 107(4):844-856, 2022. e-Pub 2022. PMID: 34435482.
- Saliba RM, Srour SA, Greenbaum U, Ma Q, Carmazzi Y, Moller M, Wood J, Ciurea SO, Kongtim P, Rondon G, Li D, Saengboon S, Alousi AM, Rezvani K, Shpall EJ, Cao K, Champlin RE, Zou J. SIRPα Mismatch Is Associated With Relapse Protection and Chronic Graft-Versus-Host Disease After Related Hematopoietic Stem Cell Transplantation for Lymphoid Malignancies. Front Immunol 13, 2022. e-Pub 2022. PMID: 35874659.
- Zou J, Wang T, He M, Bolon YT, Gadalla SM, Marsh SGE, Kuxhausen M, Gale RP, Sharma A, Assal A, Prestidge T, Aljurf M, Cerny J, Paczesny S, Spellman SR, Lee SJ, Ciurea SO. Number of HLA mismatched eplets is not associated with major outcomes in haploidentical transplantation with post-transplantation cyclophosphamide: A Center for International Blood and Marrow Transplant Research Study. Transplant Cell Ther 28(2):107.e1-107.e8, 2022. e-Pub 2022. PMID: 34774819.
- Zou J, Kongtim P, Srour SA, Greenbaum U, Schetelig J, Heidenreich F, Baldauf H, Moore B, Saengboon S, Carmazzi Y, Rondon G, Ma Q, Rezvani K, Shpall EJ, Champlin RE, Ciurea SO, Cao K.. Donor Selection for KIR alloreactivity is associated with superior survival in haploidnetical transplant with PTCy. Front Immunol 13, 2022. PMID: 36311784.
- Ciurea S, Malki MM, Kongtim P, Zou J, Aung FM, Rondon G, Chen J, Taniguchi M, Otoukesh S, Nademanee A, Forman SJ, Champlin RE, Gendzekhadze K, Cao K. Treatment of allosensitized patients receiving allogeneic transplantation. Blood Adv 5(20):4031-4043, 2021. PMID: 34474478.
- Saliba RM, Greenbaum U, Ma Q, Srour S, Ciurea S, Carmazzi Y, Li L, Oran B, Moller M, Wood J, Ciurea S, Kongtim P, Rondon G, Partlow D, Li D, Rezvani K, Shpall E, Champlin RE, Zou J. Mismatch in SIRPα, a regulatory protein in innate immunity, is associated with chronic GVHD in hematopoietic stem cell transplantation. Blood Advances 5(17):3407-3417, 2021. PMID: 34495313.
- Zou J, Ciurea S, Kongtim P, Yi M, Carmazzi Y, Rondon G, Srour S, Partlow D, Champlin RE, Cao K. Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantation. Blood Adv 4(15):3474-3485, 2020. PMID: 32726398.
- Zou J, Duffy B, Slade M, Young AL, Steward N, Hachem R, Mohanakumar T. Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch. Hum Immunol 78(4):342-349, 2017. e-Pub 2017. PMID: 28267558.
- Zou J, Slade M, Romee R, Phelan D, Willey P, Mohanakumar T, Grossman BJ. Prozone Phenomenon Complicates Detection of Donor Specific Antibodies in Haploidentical Hematopoietic Cell Transplant Patients. Journal of Transplantation Research 1 (2)(2473-1730), 2016.
- Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP. Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A 109(24):9539-9544, 2012. e-Pub 2012. PMID: 22647598.
- Zou J, Chang SC, Marjanovic J, Majerus PW. MTMR9 Regulates MTMR6 Enzymatic Activity and Regulation of Apoptosis. Journal of Biological Chemistry 284(4):2064-2071, 2009. PMID: 19038970.
- Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW. Type I Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Regulates Stress-Induced Apoptosis. Proc Natl Acad Sci U S A 104(43):16834-16839, 2007. e-Pub 2007. PMID: 17940011.
- Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A 102(52):18854-18859, 2005. e-Pub 2005. PMID: 16365287.
- Zou J, Glinsky VV, Landon LA, Matthews L, Deutscher SL. Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis 26(2):309-318, 2005. e-Pub 2004. PMID: 15528216.
- Zou J, Dickerson MT, Owen NK, Landon LA, Deutscher SL. Biodistribution of filamentous phage peptide libraries in mice. Mol Biol Rep 31(2):121-129, 2004. PMID: 15293788.
- Landon LA, Zou J, Deutscher SL. Effective combinatorial strategy to increase affinity of carbohydrate binding by peptides. Mol Divers 8(1):35-50, 2004. PMID: 14964786.
- Zhang X, Yan B, Zou J. Resuscitation from Hemorrhagic Shock with Small-volume hypertonic sodium chloride solution/gelofusine in dogs. Journal of Peking University (Health Sciences) 32:64-67, 2000.
- Zou J, Yan B, Zhang J, Zhang X. Effects of different ventilatory strategies on ventilator-induced lung injury: A study in a rabbit model of acute lung injury. Journal of Peking University. (Health Sciences) 31:432-435, 1999.
Invited Articles
- Zou J, Grossman B, Mohanakumar T. Screening platelet pheresis donors for HLA antibodies. ASHI Quarterly 38(4):28-32, 2014.
- Marjanovic J, Wilson MP, Zhang C, Zou J, Nicholas P, Majerus PW. The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model. Adv Enzyme Regul 51(1):101-105, 2011. e-Pub 2010. PMID: 21110994.
- Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson M. The role of myotybularin-related phosphatases in the control of autophagy and programmed cell death. Advances in Enzyme Regulation 52:282-289, 2011. PMID: 22056831.
- Majerus PW, Zou J, Marjanovic J, Kisseleva MV, Wilson MP. The role of inositol signaling in the control of apoptosis. Adv Enzyme Regul 48(1):10-17, 2008. e-Pub 2008. PMID: 18486622.
- Landon LA, Zou J, Deutscher SL. Is phage display technology on target for developing peptide-based cancer drug?. Curr Drug Discov Technol 1(2):113-132, 2004. PMID: 16472251.
Book Chapters
- Cao K, Zou J, Fernández-Viña M. Chapter 3: Role of the human leukocyte antigen (HLA) system in hematopoietic stem cell transplantation (HSCT). In: Manual of Stem Cell Transplantation and Cellular Therapies for Hematologic Malignancies. Elsevier Publishing. In Press.
Letters to the Editor
- Ciurea S, Cao K, Zou J. Donor-specific anti-HLA antibodies and Recipient-specific anti-HLA antibodies? The conundrum on pregnancy in transplantation. American Journal of hematology 95: E128-E130, 2020.
- Zou J, Romee R, Slade M, Phelan D, Keller J, Mohanakumar T, Grossman BJ. Untreated donor specific antibodies against HLA are associated with poor outcomes in peripheral blood haploidentical hematopoietic cell transplantation. Bone Marrow Transplantation 52: 898-901, 2017.
- Zou J, Nolan DK, LaFiore AR, Scott MG. Estimating the effects of hemolysis on potassium and LDH laboratory results. Clin Chim Acta 421 (5 June 2013): 60-61, 2013.
Grant & Contract Support
| Title: | Evaluation of the impact of HLA molecular mismatch on clinical outcomes in patients who underwent haploidentical hematopoietic stem cell transplantation |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-Principal Investigator |
| Title: | SIRPα mismatch and the outcome of Allo-HSCT in patients with hematologic malignancy. Funding Source: MD Anderson Cancer Center Internal Research Grant, two years |
| Funding Source: | MD Anderson |
| Role: | Principal Investigator |
| Title: | Impact of HLA-DPB1 matching on clinical outcomes following unrelated donor transplantation using post-transplant cyclophosphamide as GVHD prophylaxis for patients with hematologic malignancies |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-Principal Investigator |
| Title: | Effect of SIRPa mismatch on the outcome of allogeneic hematopoietic stem cell transplantation from an HLA-matched related donor |
| Funding Source: | Center for International Blood and Marrow Transplant Research (CIBMTR) |
| Role: | Co-Principal Investigator |