Jyotika Sharma, M.Phil., Ph.D.
Department of Critical Care Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Critical Care Medicine - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor (Tenured),, Department of Critical Care, The University of Texas MD Anderson Cancer Center
Research Interests
The current research focus of my laboratory is to understand myeloid cell functions in lung microenvironment during acute and chronic inflammatory diseases. Specifically, my research group is engaged in understanding the neutrophil generation, turnover and effector functions in regulation of inflammation in pneumonia, sepsis, Chronic Granulomatous Disease (CGD) and Chronic Obstructive Pulmonary Disease (COPD). More recently, in collaboration with industry partners and clinicians at MDACC, we have expanded our research to understand the mechanisms and implications of neutrophil extracellular trap formation in breast cancer patients and septic oncologic patients. My laboratory provides a research-intensive environment for training graduate and undergraduate students, postdoctoral fellows and junior investigators. I have served as the Director of NIH-funded P20 Center for Biomedical Research Excellence (COBRE) on host-pathogen interactions. In Phase I funding period, this COBRE was focused on infrastructure development, mentoring and career development of early career (tenure-track) Assistant Professors working on various aspects of host responses to viral, bacterial and parasitic infections. Before moving to MDACC in Oct-2020, I worked with the Phase I team to submit the Phase II renewal proposal, which was funded in July, 2021. Currently, I serve on the External Advisory Board of this COBRE with an active role in advising the PIs and serving as liaison with the NIH to evaluate the progress of research projects and core facilities affiliated with the COBRE, review replacement projects, make recommendations and provide critical input for improvement of the program
Education & Training
Degree-Granting Education
| 2001 | Kanpur University, Kanpur, IN, Ph.D. in Microbiology |
| 1996 | Delhi University, Dehli, IN, M. Phil in Microbiology |
| 1994 | Delhi University, Delhi, IN, M. Sc in Botany |
Postgraduate Training
| 2001-2005 | Postdoctoral Fellowship, University of Texas Health Science Center San Antonio, San Antonio, Texas |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, 2016 - 2020
Assistant Professor, Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, 2011 - 2016
Research Assistant Professor, Biology Department, The University of Texas at San Antonio, San Antonio, TX, 2006 - 2011
Administrative Appointments/Responsibilities
Director, Biomedical Sciences, University Of North Dakota, Grand Forks, North Dakota, 2016 - 2020
Other Professional Positions
External Advisory Board, University of North Dakota, 2021 - Present
Dean-Appointed Member, University of North Dakota, Grand Forks, ND, 2016 - 2017
Judge, University of North Dakota, 2014 - 2015
Judge, Annual Frank Low Research Day presentations, University of North Dakota, 2014 - 2015
Intramural Institutional Committee Activities
Chair, Graduate Admissions Committee, The University of North Dakota, 2019 - 2020
Dean-Appointed Member, University Bylaws Committee, The University of North Dakota, 2018 - 2020
Member, Doctoral Advisory Committee, The University of North Dakota, 2016 - 2021
Member, Committee on Promotion and Tenure, The University of North Dakota, 2016 - 2020
Dean-appointed member, Medical Curriculum Committee, The University of North Dakota, 2016
Member, Departmental Research Committee, The University of North Dakota, 2015 - 2020
Member, Faculty Search Committee for Dept. of Biomedical Sciences, The University of North Dakota, 2014 - 2016
Member, Steering Committee for the new SMHS Building, University of North Dakota, 2014
Dean-appointed Member, Health Sciences Curriculum Committee, The University of North Dakota, 2012 - 2015
Extramural Institutional Committee Activities
Member, Mid-career Faculty Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Education and Research Day Committee, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, GSBS Student Scholarship Committee, UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Institutional Committee for Research Enablement, Activities and Conduct (REACT), The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Division Research Committee, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, 2021 - Present
Honors & Awards
| 2021 | President’s Recognition of Faculty Research Excellence, University of Texas MD Anderson Cancer Center |
| 2019 | Dean’s Special Recognition Award for outstanding Research and Service Contributions, University of North Dakota School of Medicine |
| 2016 - Present | Careers in Immunology Fellowship for graduate student, American Association of Immunologists |
| 2014 | Travel for Techniques Award, American Association of Immunologists |
| 2014 | Early Career Faculty Travel Award, American Association of Immunologists |
| 2013 | Feature on North Dakota Discovery, “Focus on Faculty”, University of North Dakota |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Cancer drugs for modulation of NETs in infection and inflammation. Research Town Hall. Houston, Texas, US.
- 2023. Neutrophils in Cancer: Prognostic and Therapeutic Opportunities. Frontiers in Critical Care. Houston, Texas, US.
- 2021. Neutrophil Extracellular Traps: From Bench to Bedside and Back. Invited. Research in Progress Seminar Series. Houston, Texas, US.
- 2021. MMG/MID Retreat. MMG/MID Retreat. Houston, Texas, US.
- 2019. Principles of Effective Grant Writing: STEM. Invited. Grand Forks, ND, US.
- 2018. NIH Grant-writing workshop. Invited. Grand Forks, ND, US.
- 2018. To kill or be killed: Neutrophils in bacterial pneumosepsis. PLENARY TALK, SESSION IV: Bench to Bedside Translation of Therapeutics- at the Crossroads of Immunity and Host Defense. Conference. 41st Annual Conference on Shock (Shock 2018). Scottsdale, AZ, US.
- 2016. Neutrophil Extracellular Traps: From Basic Science to Clinical Application. Conference. Neutrophil Extracellular Traps: From Basic Science to Clinical Application. Grand Fork, ND, US.
- 2013. For better or For Worse: C-type lectin receptors contribute to pathology and protection in pneumonic sepsis. Conference. For better or For Worse: C-type lectin receptors contribute to pathology and protection in pneumonic sepsis. Grand Fork, ND, US.
- 2012. Sepsis development in pulmonary bacterial infections: C-type lectins sounding the alarm?. Conference. Sepsis development in pulmonary bacterial infections: C-type lectins sounding the alarm?. Fargo, ND, US.
- 2006. Molecular Basis of Chlamydia Pathogenesis. Conference. Molecular Basis of Chlamydia Pathogenesis. San Antonio, TX, US.
Regional Presentations
- 2024. Neutrophil Functions: From Bench to Bedside and Back. San Antonio, TX, US.
- 2019. Neutrophil functions in acute and chronic lung diseases. Conference. Neutrophil functions in acute and chronic lung diseases. Oklahoma City, OK, US.
- 2018. Regulation of Neutrophil Extracellular Trap Formation and Therapeutic Implications. Invited, US.
- 2017. Neutrophil Extracellular Traps: Formation and Therapeutic Implications. Invited. Department of Comparative Biomedical Sciences, US.
- 2016. Regulation of Neutrophil Functions: Implications for acute and chronic inflammatory diseases. Tucson, AZ, US.
- 2016. The Yin and Yang of Lung Inflammation: Neutrophils take the center stage. Conference. The Yin and Yang of Lung Inflammation: Neutrophils take the center stage. Grand Fork, ND, US.
- 2014. Taking Care of the Living and Burying the Dead: C-type Lectin Receptors Stand Guard. San Antonio, TX, US.
- 2003. Global identification of chalmydial proteins that potentially interact with the host molecules. Conference. Global identification of chalmydial proteins that potentially interact with the host molecules. Memphis, TN, US.
National Presentations
- 2025. Neutrophil Functions: From Bench to Bedside and Back. Neutrophil Functions: From Bench to Bedside and Back, US.
- 2022. A new NET inducing ligand of Mincle. GRC on the Biology of Acute Respiratory Infection. Ventura, CA, US.
- 2019. Neutrophil Extracellular Traps: Formation and Therapeutic Implications. Invited. Neutrophil Extracellular Traps: Formation and Therapeutic Implications. Milwaukee, WI, US.
- 2019. Neutrophil Functions: From Bench to Bedside and Back. Invited. Neutrophil Functions: From Bench to Bedside and Back, US.
- 2019. Neutrophils in Health and Disease. Invited. National Jewish Health, US.
- 2019. Neutrophil Functions: From Bench to Bedside. Invited. 42nd Annual Conference on Shock. Coronado, CA, US.
- 2019. Neutrophil Functions: From Bench to Bedside and Back. Invited. Neutrophil Functions: From Bench to Bedside and Back, US.
- 2018. To kill or be killed: Neutrophils in bacterial pneumosepsis. Plenary talk, session IV: Bench to Bedside Translation of Therapeutics- at the Crossroads of Immunity and Host Defense. Conference. 41st Annual Conference on Shock (Shock 2018). Scottsdale, AZ, US.
International Presentations
- 2024. Pyroptosis independent function of NLRP3 inflammasome in neutrophil extracellular trap formation. Neutrophil 2024. Munich, DE.
- 2018. Klebsiella pneumoniae infection of neutrophils inhibits their efferocytic clearance by modulating cell death pathway. Conference. Neutrophil 2018. Quebec City, CA.
Formal Peers
- 2021. Neutrophil Extracellular Traps: From Bench to Bedside and Back. Invited. Houston, TX, US.
- 2021. MMG/MID Retreat. Invited, US.
- 2019. Principles of Effective Grant Writing: STEM. Invited. Grand Fork, ND, US.
- 2019. Neutrophil Functions: From Bench to Bedside and Back. Invited. Gainesville, FL, US.
- 2019. Neutrophils in Health and Disease. Invited, US.
- 2018. Regulation of Neutrophil Extracellular Trap Formation and Therapeutic Implications. Invited. Riverside, CA, US.
- 2017. Neutrophil Extracellular Traps: Formation and Therapeutic Implications. Invited. New Orleans, LA, US.
- 2016. Regulation of Neutrophil Functions: Implications for acute and chronic inflammatory diseases. Invited. Tucson, TX, US.
- 2014. Taking Care of the Living and Burying the Dead: C-type Lectin Receptors Stand Guard. Invited. San Antonio, TX, US.
Grant & Contract Support
| Date: | 2026 - Present |
| Title: | Circulating NET nucleosomes for early detection of sepsis in cancer patients |
| Funding Source: | NCI/NIH |
| Role: | PI |
| ID: | R01CA310947 |
| Date: | 2026 - Present |
| Title: | Prognostic application of circulating NET DNA in breast cancer |
| Funding Source: | NCI/NIH |
| Role: | PI |
| ID: | 1R21CA317409-01 |
| Date: | 2026 - Present |
| Title: | Drivers of Neutrophil Maturation and Effector Functions in host defense |
| Funding Source: | NIAID/NIH |
| Role: | PI |
| ID: | 1R01AI201125-01 |
| Date: | 2024 - 2026 |
| Title: | Impact of tamoxifen treatment on neutrophils in breast cancer patients |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R21AI |
| Date: | 2023 - 2025 |
| Title: | Correlation of circulating NETs and cell-free DNA with inflammatory immune responses in cancer patients with sepsis |
| Funding Source: | Volition RX |
| Role: | PI |
| Date: | 2021 - 2026 |
| Title: | Lung macrophage Memory Development and Responses in Secondary Pneumonia and Sepsis |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | R01AI164721 |
| Date: | 2021 - 2026 |
| Title: | Neutrophil extracellular traps in host immunity |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R01AI155582 |
| Date: | 2019 - 2020 |
| Title: | Neutrophil Function in Breast Cancer |
| Funding Source: | University of North Dakota |
| Role: | PI |
| ID: | Pilot grant-DaCCoTTA CTR (NIH U54GM128729) |
| Date: | 2019 - 2020 |
| Title: | Molecular mechanism of Mincle mediated NET formation: Implications for pneumonic sepsis |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R01AI121804-S1 |
| Date: | 2018 - 2019 |
| Title: | Restoring neutrophil extracellular trap formation: Implications for neonatal sepsis |
| Funding Source: | University of North Dakota |
| Role: | PI |
| ID: | University Research Pilot Grant Program |
| Date: | 2017 - 2020 |
| Title: | Efferocytosis and neutrophil homeostasis in pneumonic sepsis |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R21AI136472 |
| Date: | 2016 - 2021 |
| Title: | Center for Excellence in-host Pathogen Interactions |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | P20GM113123 |
| Date: | 2016 - 2018 |
| Title: | Effect of cigarette smoke exposure on neutrophil function in COPD |
| Funding Source: | University of North Dakota |
| Role: | PI |
| Date: | 2015 - 2022 |
| Title: | Molecular mechanism of Mincle mediated NET formation: Implications for pneumonic sepsis |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R01AI121804 |
| Date: | 2014 - 2016 |
| Title: | Identification of protective proteins of Francisella using a novel comparative immunoproteomics approach |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R21AI107457 |
| Date: | 2013 - 2014 |
| Title: | Mechanisms of protective function of C-type lectin receptors in resolution of pneumonic sepsis |
| Funding Source: | University of North Dakota |
| Role: | PI |
| Date: | 2012 - 2015 |
| Title: | Mechanism of sepsis development in pulmonary bacterial infection |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R21AI101644 |
| Date: | 2010 - 2012 |
| Title: | Role of galectin-3 and galectin-9 as alarmins in respiratory Francisella induced sepsis |
| Funding Source: | American Heart Association |
| Role: | PI |
| ID: | 10BGIA4300041 |
Selected Publications
Peer-Reviewed Articles
- Sharma, A, Kandy RRK, Jasrotia RS, Chauhan, A, Chilamakuri R, Li Q, Gupta P, Zerbe C, Holland SH, Mishra, BB, Sharma J. Tamoxifen protects against respiratory immunopathogenesis of Granulibacter bethesdensis in murine model of chronic granulomatous disease. J Allergy Clin Immunol. e-Pub 2026.
- Chilamakuri R, Sharma A., Yepez Gonzalez PC, Nair S., Gupta P., Kandy RRK, Cuenca J., Zhou X., Singareeka Raghavendra, A, Fuqua S., Tripathy D, Barcenas, C, Sharma J. Prolonged tamoxifen treatment modulates neutrophil phenotype and augments NET formation in breast cancer patients. e-Pub 2025.
- Sharma, A, Kandy RRK, Jasrotia, RS, Chauhan, A, Chilamakuri R, Li Q, Gupta P, Zerbe C, Holland, SH, Mishra, BB, Sharma J. IFN-γ driven pathogenesis of Granulibater bethesdensis pulmonary infection in Chronic Granulomatous Disease. e-Pub 2025.
- Kandy RRK, Jasrotia, R, Tripathy, JK, Sharma, A, Paul, B, Mishra, BB, Sharma J. Epigenetic characterization of NETome identifies diagnostic markers in bacterial and viral infection. e-Pub 2025.
- Delinois, LJ, Sharma, A, Ramesh, AK, Boatright, LD, Li, Q, Xu, R, Luo, HR, Mishra, B, Sharma, J. Poly(ADP-Ribose) Polymerase-1 Regulates Pyroptosis Independent Function of NLRP3 Inflammasome in Neutrophil Extracellular Trap Formation. ImmunoHorizons 8(8):586-597, 2024. e-Pub 2024. PMID: 39186692.
- Sharma, A, Chauhan, A, Chauhan, P, Evans, DL, Szlabick, RE, Aaland, MO, Mishra, B, Sharma, J. Glycolipid Metabolite β-Glucosylceramide Is a Neutrophil Extracellular Trap-Inducing Ligand of Mincle Released during Bacterial Infection and Inflammation. Journal of Immunology 209(2):391-400, 2022. e-Pub 2022. PMID: 35768151.
- Ward SE, O'Sullivan JM, Moran AB, Spencer DIR, Gardner RA, Sharma J, Fazavana J, Monopoli M, McKinnon TAJ, Chion A, Haberichter S, O'Donnell JS. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance. Haematologica 107(3):668-679, 2022. e-Pub 2022. PMID: 33763999.
- Chauhan A, Sharma A, Tripathi JK, Sun Y, Sukumran P, Singh BB, Mishra BB, Sharma J. Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis. Sci Rep 11(1):12718, 2021. e-Pub 2021. PMID: 34135384.
- Sharma A, McCann K, Tripathi JK, Chauhan P, Zerbe C, Mishra BB, Holland SM, Sharma J. Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner. J Allergy Clin Immunol 144(2):597-600.e3, 2019. e-Pub 2019. PMID: 31039377.
- Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede FO, Jondle CN, Sharma A, Evans DL, Chauhan P, Szlabick RE, Aaland MO, Birnbaumer L, Sharma J, Singh BB, Mishra BB. M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. iScience 8:85-102, 2018. e-Pub 2018. PMID: 30293012.
- Jondle CN, Gupta K, Mishra BB, Sharma J. Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery. PLoS Pathog 14(10):e1007338, 2018. e-Pub 2018. PMID: 30273394.
- Quenum Zangbede FO, Chauhan A, Sharma J, Mishra BB. Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover. J Neurosci 38(30):6737-6750, 2018. e-Pub 2018. PMID: 29946038.
- Tripathi JK, Sharma A, Sukumaran P, Sun Y, Mishra BB, Singh BB, Sharma J. Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection. FASEB J:fj201800605, 2018. PMID: 29906250.
- Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS. A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance. Blood 131(8):911-916, 2018. e-Pub 2018. PMID: 29282218.
- Sharma A, Simonson TJ, Jondle CN, Mishra BB, Sharma J. Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy. J Infect Dis 215(7):1040-1048, 2017. e-Pub 2017. PMID: 28186242.
- Jondle CN, Sharma A, Simonson TJ, Larson B, Mishra BB, Sharma J. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia. J Immunol 196(7):3088-96, 2016. e-Pub 2016. PMID: 26912318.
- Chauhan A, Quenum FZ, Abbas A, Bradley DS, Nechaev S, Singh BB, Sharma J, Mishra BB. Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in Neurocysticercosis. ASN Neuro 7(4), 2015. e-Pub 2015. PMID: 26148848.
- Steichen AL, Simonson TJ, Salmon SL, Metzger DW, Mishra BB, Sharma J. Alarmin function of galectin-9 in murine respiratory tularemia. PLoS One 10(4):e0123573, 2015. e-Pub 2015. PMID: 25898318.
- Sun Y, Chauhan A, Sukumaran P, Sharma J, Singh BB, Mishra BB. Inhibition of store-operated calcium entry in microglia by helminth factors: implications for immune suppression in neurocysticercosis. J Neuroinflammation 11:210, 2014. e-Pub 2014. PMID: 25539735.
- Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J. Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation. J Infect Dis 209(11):1837-46, 2014. e-Pub 2014. PMID: 24353272.
- Chauhan A, Sun Y, Pani B, Quenumzangbe F, Sharma J, Singh BB, Mishra BB. Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity. PLoS One 9(7):e101023, 2014. e-Pub 2014. PMID: 25013939.
- Steichen AL, Binstock BJ, Mishra BB, Sharma J. C-type lectin receptor Clec4d plays a protective role in resolution of Gram-negative pneumonia. J Leukoc Biol 94(3):393-8, 2013. e-Pub 2013. PMID: 23709686.
- Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, Sharma J. Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia. PLoS One 8(3):e59616, 2013. e-Pub 2013. PMID: 23527230.
- Sharma J, Mares CA, Li Q, Morris EG, Teale JM. Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain. Microb Pathog 51(1-2):39-47, 2011. e-Pub 2011. PMID: 21440052.
- Mares CA, Sharma J, Li Q, Rangel EL, Morris EG, Enriquez MI, Teale JM. Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections. Immunol Cell Biol 89(2):167-72, 2011. e-Pub 2011. PMID: 20585334.
- Sharma J, Mishra BB, Li Q, Teale JM. TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu. Cell Immunol 269(2):69-73, 2011. e-Pub 2011. PMID: 21497800.
- Mares CA, Sharma J, Ojeda SS, Li Q, Campos JA, Morris EG, Coalson JJ, Teale JM. Attenuated response of aged mice to respiratory Francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia. PLoS One 5(11):e14088, 2010. e-Pub 2010. PMID: 21124895.
- Sharma J, Li Q, Mishra BB, Georges MJ, Teale JM. Vaccination with an attenuated strain of Francisella novicida prevents T-cell depletion and protects mice infected with the wild-type strain from severe sepsis. Infect Immun 77(10):4314-26, 2009. e-Pub 2009. PMID: 19635830.
- Sharma J, Li Q, Mishra BB, Pena C, Teale JM. Lethal pulmonary infection with Francisella novicida is associated with severe sepsis. J Leukoc Biol 86(3):491-504, 2009. e-Pub 2009. PMID: 19401387.
- Sharma J, Li Q, Mishra BB, Teale JM. Lethal pulmonary infection with Francisella novicida causes depletion of alphabeta T cells from lungs. Cell Immunol 257(1-2):1-4, 2009. e-Pub 2009. PMID: 19356746.
- Chen C, Chen D, Sharma J, Cheng W, Zhong Y, Liu K, Jensen J, Shain R, Arulanandam B, Zhong G. The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis. Infect Immun 74(8):4826-40, 2006. e-Pub 2006. PMID: 16861671.
- Sharma J, Zhong Y, Dong F, Piper JM, Wang G, Zhong G. Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect Immun 74(3):1490-9, 2006. e-Pub 2006. PMID: 16495519.
- Sharma J, Dong F, Pirbhai M, Zhong G. Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis. Infect Immun 73(7):4414-9, 2005. e-Pub 2005. PMID: 15972540.
- Sharma J, Bosnic AM, Piper JM, Zhong G. Human antibody responses to a Chlamydia-secreted protease factor. Infect Immun 72(12):7164-71, 2004. e-Pub 2004. PMID: 15557641.
- Murthy AK, Sharma J, Coalson JJ, Zhong G, Arulanandam BP. Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice. Cell Immunol 230(1):56-64, 2004. e-Pub 2004. PMID: 15541719.
- Dong F, Sharma J, Xiao Y, Zhong Y, Zhong G. Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors. Infect Immun 72(7):3869-75, 2004. e-Pub 2004. PMID: 15213129.
- Sharma J, Niu Y, Ge J, Pierce GN, Zhong G. Heat-inactivated C. pneumoniae organisms are not atherogenic. Mol Cell Biochem 260(1-2):147-52, 2004. e-Pub 2004. PMID: 15228096.
- Belland RJ, Zhong G, Crane DD, Hogan D, Sturdevant D, Sharma J, Beatty WL, Caldwell HD. Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A 100(14):8478-83, 2003. e-Pub 2003. PMID: 12815105.
- Singh A, Sharma J, Rexer KH, Varma A. Plant productivity determinants beyond minerals, water and light: Piriformospora indica - A revolutionary plant growth promoting fungus. Current Science 79(11):1548-1554, 2000. e-Pub 2000.
- Gupta, P, Sharma, A.,, Morel, P, Yepez Gonzalez PC, Nair, S, Chilamakuri R, Kandy RRK, Cuenca, J, Zhou X, Gaeta S, Gutierrez, C, Cata, J, Malik, I, Sharma J. Circulating neutrophil extracellular trap nucleosomes as biomarker for sepsis severity in cancer patients with solid tumors.
Invited Articles
- Samarasinghe AE, Randell SH, Kulkarni HS, Weiser JN, Quinton LJ, Dickson RP, Mizgerd JP, Orihuela CJ, Parker D, Robinson KM, Prince AS, Evans SE, Kolls JK, Lee JS, Jeyaseelan S, Torres A, Miller LA, Hamilton DJ, Gómez MI, Moore BB, Walker RL, Barkal LJ, Hook JL, Lau GW, Sharma J, Witzenrath M, Dela Cruz CS. Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Repor. Am J Respir Cell Mol Biol 73(2):178-199, 2025. e-Pub 2025. PMID: 40748059.
Review Articles
- Villa, JF, Ramirez Manotas, MF, Anderson, JL, Sikora, AG, Sharma, J, Cata, JP. Perioperative Immunomodulation and Cancer Recurrence. International Anesthesiology Clinics 64(2):29-42, 2026. e-Pub 2026. PMID: 41525257.
- Kalari Kandy, RR, Arumugam, MK, Yadav, MP, Mishra, B, Sharma, J. ARID4B: An Orchestrator from Stem Cell Fate to Carcinogenesis. Cells 14(12), 2025. e-Pub 2025. PMID: 40558499.
- Tripathi JK, Sharma A, Gupta K, Abdelrahman H, Chauhan P, Mishra BB, Sharma J. Function of SLAM-Associated Protein (SAP) in Acute Pneumoseptic Bacterial Infection. J Mol Biol 431(21):4345-4353, 2019. e-Pub 2019. PMID: 31295456.
- Villa JF, Ramirez MF, Sharma J, Cata JP. Perioperative Immunomodulation and Cancer Recurrence.
Abstracts
- Sharma A, Chauhan A, Ramesh A, Mishra BB, Sharma J. Pulmonary Immunopathogenesis of Granulibacter bethesdensis, 2023. e-Pub 2023.
- Tripathi JK, Sharma A, Gupta K, Abdelrahman H, Bibhuti BM, Sharma J. Innate protective function of SLAM-associated Protein (SAP) in regulating neutrophil extracellular trap formation during bacterial pneumoseptic infection. SHOCK 51(6):11-164, 2019. e-Pub 2019.
- Tripathi JK, Sharma A, Sukumaran P, Mishra B, Singh B, Sharma J. Oxidant sensor cation channel TRPM2 activates neutrophil extracellular trap formation by autophagy and plays a protective role in pneumoseptic Klebsiella pneumoniae infection, 2018. e-Pub 2018.
- Sharma J. To kill or be killed: Neutrophils in bacterial pneumosepsis. SHOCK 49(6):9-142, 2018. e-Pub 2018.
- Jondle CN, Mishra B, Sharma J. Macrophage galactose-type lectin 1 (MGL-1) regulates neutrophil mobilization during pulmonary Gram negative pneumonia, 2017. e-Pub 2017.
- Sharma J, Tripathi J, Sharma, Jondle CN, Mishra B. Protective function of Calcium permeable cation channel TRPM2 during pneumoseptic Klebsiella pneumoniae infection, 2017. e-Pub 2017.
- Sharma A, Simonson TJ, Jondle CN, Mishra B, Sharma J. Mincle regulates autophagy to control neutrophil extracellular trap formation, 2017. e-Pub 2017.
- Fredice Quenum Zangbede, Arun Chauhan, Sharma J, Bibhuti B Mishra. Galectin-7 regulates infiltration of alternatively activated macrophages into the central nervous system, 2017. e-Pub 2017.
- Sharma J, Jondle CN, Sharma, Simonson TJ, Mishra B. Macrophage Galactose-Type Lectin-1 (MGL1) Deficiency Is Associated with Increased Lung Pathology and Hyperinflammation in Gram-Negative Pneumonia, 2016. e-Pub 2016.
- Jondle CN, Bibhuti M, Sharma J. Impact of Klebsiella pneumoniae on efferocytosis of polymorphonuclear cells, 2016. e-Pub 2016.
- Sharma J, Steichen A, Simonson T, Salmon S, Metzger D, Mishra B. Alarmin function of galectin-9 in murine respiratory tularemia 194(1), 2015. e-Pub 2015.
- Sharma J, Sharma A, Steichen A, Jondle C, Binstock B, Mishra B. Antibacterial and pro-resolving mechanisms in lung diseases: role of C-type lectin receptors, 2014. e-Pub 2014.
Book Chapters
- 1Varma A, Singh A, Sudha, Sahay N, Sharma J, Roy A, Kumari M, Rana D, Thakran S, Deka D, Bharti K, Franken P, Hurek T, Blechert O, Rexer K, Kost G, Hahn A, Hock B, Maier W, Walter M, Strack D and Kranner I. Piriformospora indica: an axenically culturable mycorrhiza-like endosymbiotic fungus. In: Fungal Associations. 1. Springer-Verlag Berlin Heidelberg, 125-150, 2000.
Patient Reviews
CV information above last modified July 22, 2026