About Dr. Kadir C. Akdemir
Kadir Akdemir, Ph.D. is an Assistant Professor of the Department of Neurosurgery at MD Anderson. Raised in Turkey, he studied computer science and genetics at Yeditepe University in Istanbul. He obtained a PhD from the University of Texas Health Science Center at Houston for his work on p53 protein’s functions during human embryonic stem cell differentiation. He then completed his post-doctoral training with Dr. Andrew Futreal at MD Anderson’s Genomic Medicine department on cancer genomics and three-dimensional chromatin organization. His work on the integration of the three-dimensional chromatin organization with cancer genomic datasets provided unique insights into the mechanisms and consequences of somatic alterations observed in human tumors (Akdemir et al. Nature Genetics - PMID: 3302066; Akdemir et. al. Nature Genetics - PMID: 32024999). He has an extensive research program focused on genomic alterations observed in human central nervous system tumors.
Dr. Akdemir has been part of the several international genomic efforts such as the International Cancer Genome Consortia’s pan-cancer whole-genome analyses initiative and NIH’s 4Dnucleome comprehensive chromatin profiling initiative. He holds multiple foundation grants. He is collaborating with the world-renowned brain cancer researchers by being a part of the MD Anderson’s SPORE in Brain Cancer Program, GBM Moonshot program and the Break Through Cancer’s GBM program.
His lab has developed a large set of techniques to study mechanisms and patterns of chromatin folding and somatic rearrangements that occur in cancer genomes during neoplastic transformation.
Assistant Professor, University of Texas MD Anderson Cancer Center, Neurosurgery Department, Houston, TX
Central Nervous System Tumors
|2013||MD Anderson Cancer Center, Houston, TX, USA, PHD, Bioinformatics|
|2008||Yeditepe University, Istanbul, TUR, BS, Computer Engineering|
|2007||Yeditepe University, Istanbul, TUR, BS, Genetics and Bioengineering|
|2013-2017||Research Fellowship, MD Anderson Cancer Center, Houston, TX|
- Akdemir KC as part of Analysis Working Group. Cancer Genome Atlas N Genomic Classification of Cutaneous Melanoma. Cell, 2015.
- Akdemir KC, Chin L HiCPlotter integrates genomic data with interaction matrices. Genome Biol, 2015.
- Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Akdemir KC Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature Genetics.
- Akdemir KC, Le V, Killcoyne S, Inoue A, Amin S, Chan K, Gerstung M, Fitzgerald R, Campbell P, Verhaak RG, Gordenin D, Dixon J, Futreal PA. Process-specific somatic mutation distributions vary with three-dimensional genome structure. Nature Genetics.