Katrien Van Roosbroeck, PhD
Department of Investigational Cancer Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2010 | Center for Human Genetics, University of Leuven (K.U.Leuven), Leuven, BEL, PHD, Biomedical Sciences |
| 2008 | University of Leuven (K.U.Leuven), Leuven, BEL, QT, Biology |
| 2005 | University of Leuven (K.U.Leuven), Leuven, BEL, MS, Bioscience Engineering (Cell and Gene Biotechnology) |
| 2002 | University of Antwerp, Antwerp, BEL, BS, Bio-Engineering |
Postgraduate Training
| 2011-2015 | Research Fellowship, Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2010-2011 | Research Fellowship, Cancer Biology, University of Leuven (K.U.Leuven), Leuven |
Experience & Service
Other Appointments/Responsibilities
Co-Chair Experimental Therapeutics Postdoctoral Fellows, The University of Texas MD Cancer Center, Houston, TX, 2013 - 2015
Honors & Awards
| 2015 | The Barrie Hesp Scholarship, Keystone Symposia on MicroRNAs and Noncoding RNAs in Cancer |
| 2015 | Women in Research Travel Grant, Cayman Chemical |
| 2015 | Travel Award, Clyde H. Wright Memorial Fund |
| 2011 | Henri Benedictus BAEF Fellowship for Research in the USA, Belgian American Education Foundation |
| 2010 | Best Abstract, XXIV Olomouc Haematology Days by the Czech Society of Hematology |
| 2010 | Travel Award, 15th Congress of the European Hematology Association |
| 2010 | Best Poster Presentation Award, 25th General Meeting of the Belgian Hematological Society |
| 2009 | Travel Award, 51st ASH Annual Meeting and Exposition (Belgian Hematological Society) |
| 2009 | Travel Award, 51st ASH Annual Meeting and Exposition (American Society of Hematology) |
| 2009 | Emmanuel van der Schueren Fellowship, Stichting Emmanuel van der Schueren |
| 2009 | Travel Award, 14th Congress of the European Hematology Association |
| 2008 | Travel Award, 13th Congress of the European Hematology Association |
| 2008 | Best Poster Presentation Award, 23rd General Meeting of the Belgian Hematological Society |
Selected Publications
Peer-Reviewed Articles
- Van Roosbroeck K, Fanini F, Setoyama T, Ivan C, Rodriguez-Aguayo C, Fuentes-Mattei E, Xiao L, Vannini I, Redis RS, D'Abundo L, Zhang X, Nicoloso MS, Rossi S, Gonzalez-Villasana V, Rupaimoole R, Ferracin M, Morabito F, Neri A, Ruvolo PP, Ruvolo VR, Pecot CV, Amadori D, Abruzzo L, Calin S, Wang X, You MJ, Ferrajoli A, Orlowski R, Plunkett W, Lichtenberg TM, Davuluri RV, Berindan-Neagoe I, Negrini M, Wistuba II, Kantarjian HM, Sood AK, Lopez-Berestein G, Keating MJ, Fabbri M, Calin GA. Combining anti-miR-155 with chemotherapy for the treatment of lung cancers. Clin Cancer Res 23(11):2891-2904, 2017. e-Pub 2016. PMID: 27903673.
- Vitale C, Falchi L, Ten Hacken E, Gao H, Shaim H, Van Roosbroeck K, Calin G, O'Brien S, Faderl S, Wang X, Wierda WG, Rezvani K, Reuben JM, Burger JA, Keating MJ, Ferrajoli A. Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation Between Responses and Immune Characteristics. Clin Cancer Res 22(10):2359-67, 2016. e-Pub 2016. PMID: 26733610.
- Van Roosbroeck K, Ferreiro JF, Tousseyn T, van der Krogt JA, Michaux L, Pienkowska-Grela B, Theate I, De Paepe P, Dierickx D, Doyen C, Put N, Cools J, Vandenberghe P, Wlodarska I. Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies. Genes Chromosomes Cancer 55(5):428-41, 2016. e-Pub 2016. PMID: 26850007.
- Van Roosbroeck K, Calin GA. MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?. Semin Oncol 43(2):209-14, 2016. e-Pub 2016. PMID: 27040698.
- Van Roosbroeck K, Calin GA. When kissing (disease) counts. Blood 127(16):1947-8, 2016. PMID: 27103742.
- Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafà R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. Mol Cell 61(4):520-34, 2016. e-Pub 2016. PMID: 26853146.
- Ferrajoli A, Ivan C, Ciccone M, Shimizu M, Kita Y, Ohtsuka M, D'Abundo L, Qiang J, Lerner S, Nouraee N, Rabe KG, Rassenti LZ, Van Roosbroeck K, Manning JT, Yuan Y, Zhang X, Shanafelt TD, Wierda WG, Sabbioni S, Tarrand JJ, Estrov Z, Radovich M, Liang H, Negrini M, Kipps TJ, Kay NE, Keating M, Calin GA. Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. EBioMedicine 2(6):572-82, 2015. e-Pub 2015. PMID: 26288818.
- Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A 112(10):E1106-15, 2015. e-Pub 2015. PMID: 25713380.
- Van Roosbroeck K, Verstovsek S, Calin GA. Long non-coding RNAs in primary myelofibrosis: the dark matter in hematopoietic progenitor cells?. Leuk Lymphoma 56(2):281-2, 2015. PMID: 25093380.
- Van Roosbroeck K, Pollet J, Calin GA. miRNAs and long noncoding RNAs as biomarkers in human diseases. Expert Rev Mol Diagn 13(2):183-204, 2013. PMID: 23477558.
- Nouraee N, Van Roosbroeck K, Vasei M, Semnani S, Samaei NM, Naghshvar F, Omidi AA, Calin GA, Mowla SJ. Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma. PLoS One 8(9):e73009, 2013. e-Pub 2013. PMID: 24039846.
- Hudson RS, Yi M, Volfovsky N, Prueitt RL, Esposito D, Volinia S, Liu CG, Schetter AJ, Van Roosbroeck K, Stephens RM, Calin GA, Croce CM, Ambs S. Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer 12:13, 2013. e-Pub 2013. PMID: 23409773.
- Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, Gervais C, Nguyen-Khac F, Chapiro E, Radford-Weiss I, Struski S, Dastugue N, Gachard N, Lefebvre C, Barin C, Eclache V, Fert-Ferrer S, Laibe S, Mozziconacci MJ, Quilichini B, Poirel HA, Wlodarska I, Hagemeijer A, Moreau Y, Vandenberghe P, Michaux L, BCGHo and the GFCH. Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course. Ann Hematol 91(6):863-73, 2012. e-Pub 2011. PMID: 22205151.
- Put N, Van Roosbroeck K, Vande Broek I, Michaux L, Vandenberghe P. PDS5A, a novel translocation partner of MLL in acute myeloid leukemia. Leuk Res 36(4):e87-9, 2012. e-Pub 2012. PMID: 22230297.
- Van Roosbroeck K, Cox L, Tousseyn T, Lahortiga I, Gielen O, Cauwelier B, De Paepe P, Verhoef G, Marynen P, Vandenberghe P, De Wolf-Peeters C, Cools J, Wlodarska I. JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma. Blood 117(15):4056-64, 2011. e-Pub 2011. PMID: 21325169.
- Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet 42(6):530-5, 2010. e-Pub 2010. PMID: 20473312.
- Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska I. ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica 95(3):509-13, 2010. PMID: 20207848.
- Van Roosbroeck K, Wlodarska I. Oncogenic anaplastic lymphoma kinase rearrangements in lymphoma. European Haematology 3(1):50-56, 2009.
- Wlodarska I, Dierickx D, Vanhentenrijk V, Van Roosbroeck K, Pospísilová H, Minnei F, Verhoef G, Thomas J, Vandenberghe P, De Wolf-Peeters C. Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. Blood 111(12):5683-90, 2008. e-Pub 2008. PMID: 18391076.
Patient Reviews
CV information above last modified March 05, 2018