Ke Li, PhD
Department of Imaging Physics, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2013 | University of Wisconsin, Madison, Wisconsin, US, Medical Physics, Ph.D |
| 2009 | Ohio State University, Columbus, Ohio, US, Physics, M.S |
| 2006 | Nanjing University, Nanjing, CN, Physics, BS |
Board Certifications
| 2019 | American Board of Radiology - Board Certification in Diagnostic Medical Physics |
Experience & Service
Academic Appointments
Associate Professor with tenure, Department of Medical Physics and Radiology, University of Wisconsin - Madison, Madison, WI, 2022 - 2024
Tenure-track Assistant Professor, Department of Medical Physics and Radiology, University of Wisconsin - Madison, Madison, WI, 2017 - 2022
Clinical health science-track Assistant Professor, Department of Medical Physics and Radiology, University of Wisconsin - Madison, Madison, WI, 2014 - 2016
Assistant Scientist, Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, 2013 - 2014
Institutional Committee Activities
Scientific Committee Member, RSNA Physics Subcommittee, 2023 - Present
Scientific Committee Member, The 7th International Conference on Image Formation in X-Ray Computed Tomography, 2022 - 2022
Scientific Committee Member, The 8th International Conference on Image Formation in X-Ray Computed Tomography, 2022 - 2022
Scientific Committee Member, SPIE Physics of Medical Imaging Conference, 2021 - Present
Scientific Committee Member, The Sixth International Conference on Image Formation in X-Ray Computed Tomography,, 2020 - 2020
Scientific Committee Member, The Fifth International Conference on Image Formation in X-Ray Computed Tomography,, 2018 - 2018
Scientific Committee Member, Task Group No. 299 - Quality Control in Multi-Energy Computed Tomography (MECT), 2016 - 2023
Honors & Awards
| Honorable Mention Poster Award, SPIE Medical Imaging Conference 2011 | |
| BEST IN PHYSICS Award, American Association of Physicists in Medicine Annual Meeting 2013 | |
| All-Conference Best Student Paper Award Runner-up, SPIE Medical Imaging Conference 2013 | |
| BEST IN PHYSICS Award, American Association of Physicists in Medicine Annual Meeting 2014 | |
| RSNA Student Travel Stipend Award, RSNA Annual Meeting 2017 | |
| DOD Breast Cancer Research Program Breakthrough Award, Department of Defense (DOD) | |
| RSNA Trainee Research Prize Award, RSNA Annual Meeting 2017 | |
| RSNA Student Travel Stipend Award, RSNA Annual Meeting 2017 | |
| BEST IN PHYSICS Award, American Association of Physicists in Medicine Annual Meeting 2020 | |
| Medical Physics journal front cover featured article and Editor’s Choice | |
| 2020 SPIE Community Champion | |
| Robert F. Wagner All-Conference Best Student Paper Award, SPIE Medical Imaging Conference | |
| American Association of Physicists in Medicine Moses & Sylvia Greenfield Award for the Best Imaging Paper published in Medical Physics during 2020, American Association of Physicists in Medicine (AAPM) | |
| Medical Physics Journal Distinguished Reviewer | |
| First Place, Robert F. Wagner All-Conference Best Student Paper Award, SPIE Medical Imaging Conference | |
| Medical Physics Journal Distinguished Associate Editor | |
| RSNA Trainee Research Prize Award, RSNA Annual Meeting 2022 | |
| Best In Physics Award, AAPM Annual Meeting 2022 | |
| Runner-up, Robert F. Wagner All-Conference Best Student Paper Award,, SPIE Medical Imaging Conference | |
| RSNA Trainee Research Prize Award,, Radiological Society of North America | |
| John R. Cameron Early-Career Investigator Symposium Finalist, American Association of Physicists in Medicine (AAPM) | |
| Distinguished Investigators of the Academy for Radiology and Biomedical Imaging Research, Academy for Radiology and Biomedical Imaging Research | |
| UW-Madison Vilas Associates Competition Award, University of Wisconsin - Madison | |
| AAPM Moses & Sylvia Greenfield Award, American Association of Physicists in Medicine (AAPM) | |
| AAPM John R. Cameron Early-Career Investigator Symposium Finalist (student: Linying Zhan), American Association of Physicists in Medicine (AAPM) |
Selected Publications
Peer-Reviewed Articles
- Hallett JE, Bruza P, Jermyn M, Li K, Pogue BW. Noise & mottle suppression methods for cumulative Cherenkov images of radiation therapy delivery. Phys Med Biol None(None):None, 2024. e-Pub 2024. PMID: 39474803.
- Leng S, Toia GV, Hoodeshenas S, Ramirez-Giraldo JC, Yagil Y, Maltz JS, Boedeker K, Li K, Baffour F, Fletcher JG. Standardizing technical parameters and terms for abdominopelvic photon-counting CT: laying the groundwork for innovation and evidence sharing. Abdom Radiol (NY) 49(9):3261-3273, 2024. PMID: 38769199.
- Zhang C, Li K, Zhang R, Chen GH. Noise power spectrum (NPS) in computed tomography: Enabling local NPS measurement without stationarity and ergodicity assumptions. Med Phys 51(7):4655-4672, 2024. e-Pub 2024. PMID: 38709982.
- Lawless M, Byrns K, Bednarz BP, Meudt J, Shanmuganayagam D, Shah J, McMillan A, Li K, Pirasteh A, Miller J. Feasibility of identifying proliferative active bone marrow with fat fraction MRI and multi-energy CT. Phys Med Biol 69(13), 2024. PMID: 38876111.
- Zhang C, Li K, Zhang R, Chen GH. Experimental measurement of local noise power spectrum (NPS) in photon counting detector-CT (PCD-CT) using a single data acquisition. Med Phys 51(6):4081-4094, 2024. e-Pub 2024. PMID: 38703355.
- Li KY, Pickett KA, Fu HW, Chen RS. Proprioceptive and olfactory deficits in individuals with Parkinson disease and mild cognitive impairment. Acta Neurol Belg 124(2):419-430, 2024. PMID: 37962784.
- Griner D, Lei N, Chen GH, Li K. Correcting statistical CT number biases without access to raw detector counts: Applications to high spatial resolution photon counting CT imaging. Med Phys 50(10):6022-6035, 2023. PMID: 37517080.
- Treb K, Radtke J, Culberson WS, Li K. Simultaneous photon counting and charge integrating for pulse pile-up correction in paralyzable photon counting detectors. Phys Med Biol 68(15), 2023. PMID: 37379858.
- Treb K, Hamisch Y, Ullberg C, Zhang R, Li K. Photon counting-energy integrating hybrid flat panel detector systems for image-guided interventions: an experimental proof-of-concept. Phys Med Biol 68(13):None, 2023. PMID: 37307849.
- Li, K, Chen, JR, Feng, M. Construction of a Nearly Unbiased Statistical Estimator of Sinogram to Address CT Number Bias Issues in Low-Dose Photon Counting CT. IEEE Transactions on Medical Imaging 42(6):1846-1858, 2023. PMID: 37022268.
- Li Y, Tie X, Li K, Zhang R, Qi Z, Budde A, Grist TM, Chen GH. A quality-checked and physics-constrained deep learning method to estimate material basis images from single-kV contrast-enhanced chest CT scans. Med Phys 50(6):3368-3388, 2023. e-Pub 2023. PMID: 36908250.
- Bushe D, Zhang R, Chen GH, Li K. Unbiased zero-count correction method in low-dose high-resolution photon counting detector CT. Phys Med Biol 68(11):None, 2023. PMID: 37137314.
- Cai EY, De Caro C, Treb K, Li K. Benefits of using removable filters in dual-layer flat panel detectors. Phys Med Biol 68(8):None, 2023. PMID: 36963117.
- Flakus MJ, Wuschner AE, Wallat EM, Shao W, Shanmuganayagam D, Christensen GE, Reinhardt JM, Li K, Bayouth JE. Quantifying robustness of CT-ventilation biomarkers to image noise. Front Physiol 14(None):1040028, 2023. PMID: 36866176.
- Treb K, Ji X, Feng M, Zhang R, Periyasamy S, Laeseke PF, Dingle AM, Brace CL, Li K. A C-arm photon counting CT prototype with volumetric coverage using multi-sweep step-and-shoot acquisitions. Phys Med Biol 67(21), 2022. PMID: 36162399.
- Lubner MG, Ziemlewicz TJ, Wells SA, Li K, Wu PH, Hinshaw JL, Lee FT Jr, Brace CL. Advanced CT techniques for hepatic microwave ablation zone monitoring and follow-up. Abdom Radiol (NY) 47(8):2658-2668, 2022. PMID: 34731282.
- Montoya JC, Zhang C, Li Y, Li K, Chen GH. Reconstruction of three-dimensional tomographic patient models for radiation dose modulation in CT from two scout views using deep learning. Med Phys 49(2):901-916, 2022. PMID: 34908175.
- Lan X, Fan K, Li K, Cai W. Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET. Eur J Nucl Med Mol Imaging 48(13):4138-4141, 2021. PMID: 33515054.
- Ji X, Feng M, Treb K, Zhang R, Schafer S, Li K. Development of an Integrated C-Arm Interventional Imaging System With a Strip Photon Counting Detector and a Flat Panel Detector. IEEE Trans Med Imaging 40(12):3674-3685, 2021. PMID: 34232872.
- Li K, Li Y, Qi Z, Garrett JW, Grist TM, Chen GH. Quantitative lung perfusion blood volume using dual energy CT-based effective atomic number (Zeff ) imaging. Med Phys 48(11):6658-6672, 2021. e-Pub 2021. PMID: 34520066.
- Lan X, Younis MH, Li K, Cai W. First clinical experience of 106 cm, long axial field-of-view (LAFOV) PET/CT: an elegant balance between standard axial (23 cm) and total-body (194 cm) systems. Eur J Nucl Med Mol Imaging 48(12):3755-3759, 2021. PMID: 34424375.
- Hayes JW, Montoya J, Budde A, Zhang C, Li Y, Li K, Hsieh J, Chen GH. High Pitch Helical CT Reconstruction. IEEE Trans Med Imaging 40(11):3077-3088, 2021. PMID: 34029189.
- Feng M, Ji X, Zhang R, Treb K, Dingle AM, Li K. An experimental method to correct low-frequency concentric artifacts in photon counting CT. Phys Med Biol 66(17):None, 2021. PMID: 34315142.
- Zhao R, Hernando D, Harris DT, Hinshaw LA, Li K, Ananthakrishnan L, Bashir MR, Duan X, Ghasabeh MA, Kamel IR, Lowry C, Mahesh M, Marin D, Miller J, Pickhardt PJ, Shaffer J, Yokoo T, Brittain JH, Reeder SB. Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom. Med Phys 48(8):4375-4386, 2021. PMID: 34105167.
- Ji X, Treb K, Li K. Anomalous edge response of cadmium telluride-based photon counting detectors jointly caused by high-flux radiation and inter-pixel communication. Phys Med Biol 66(8), 2021. e-Pub 2021. PMID: 33765661.
- Zhang R, Tie X, Qi Z, Bevins NB, Zhang C, Griner D, Song TK, Nadig JD, Schiebler ML, Garrett JW, Li K, Reeder SB, Chen GH. Diagnosis of Coronavirus Disease 2019 Pneumonia by Using Chest Radiography: Value of Artificial Intelligence. Radiology 298(2):E88-E97, 2021. PMID: 32969761.
- Zhang C, Li Y, Li K, Chen GH. DeepInterior: new pathway to address the interior tomographic reconstruction problem in CT via direct backprojecting divergent beam projection data. Proceedings of SPIE 11595(115951Q):None, 2021. PMID: None.
- Li K, Zhang R, Cai W. Deep learning convolutional neural network (DLCNN): unleashing the potential of 18F-FDG PET/CT in lymphoma. Am J Nucl Med Mol Imaging 11(4):327-331, 2021. e-Pub 2021. PMID: 34513286.
- Treb K, Feng M, Ji X, Zhang R, Schafer S, Li K. A hybrid photon counting and flat panel detector system for periprocedural hemorrhage monitoring in the angio suite. Proceedings of SPIE 11595(115950U):None, 2021. e-Pub 2021. PMID: None.
- Treb K, Li K. Accuracy of weighted CTDI in estimating average dose delivered to CTDI phantoms: An experimental study. Med Phys 47(12):6484-6499, 2020. e-Pub 2020. PMID: 33034041.
- Harvey EC, Li K. Leveraging non-contrast head CT to improve the image quality of cerebral CT perfusion maps. J Med Imaging (Bellingham) 7(6):063504, 2020. e-Pub 2020. PMID: 33363247.
- Ji X, Zhang R, Li K, Chen GH. Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging. IEEE Trans Med Imaging 39(11):3278-3289, 2020. PMID: 32340940.
- Zhang R, Fowler AM, Wilke LG, Kelcz F, Garrett JW, Chen GH, Li K. Fast acquisition with seamless stage translation (FASST) for a trimodal x-ray breast imaging system. Med Phys 47(9):4356-4362, 2020. PMID: 32458449.
- Cao L, Zhu C, Eisenmenger L, Du X, Liu J, Yang Q, Lu J, Li K, Saloner D. Wall enhancement characteristics of vertebrobasilar nonsaccular aneurysms and their relationship to symptoms. Eur J Radiol 129:109064, 2020. e-Pub 2020. PMID: 32474380.
- Li Y, Garrett JW, Li K, Strother C, Chen GH. An Enhanced SMART-RECON Algorithm for Time-Resolved C-Arm Cone-Beam CT Imaging. IEEE Trans Med Imaging 39(6):1894-1905, 2020. PMID: 31870980.
- Ji X, Zhang R, Li K, Chen GH. Is high sensitivity always desirable for a grating-based differential phase contrast imaging system?. Med Phys 47(3):1215-1228, 2020. e-Pub 2020. PMID: 31872886.
- Harvey E, Li K. Non-contrast head CT-assisted cerebral CT perfusion imaging. Proceedings of SPIE 11312(1131114):None, 2020. PMID: None.
- Griner D, Garrett JW, Li Y, Li K, Chen GH. Correction for cone beam CT image artifacts via a deep learning method. Proceedings of SPIE 11312(113124H):None, 2020. PMID: None.
- Feng M, Ji X, Zhang R, Miller J, Chen GH, Li K. Impact of photon counting detector spectral distortion on virtual non-contrast CT imaging. Proceedings of SPIE 11312(1131255):None, 2020. PMID: None.
- Li Y, Cruz-Batisda JP, Li K, Bushe D, Francois C, Lubner MG, Chen GH. Feasibility of achieving spectral CT imaging from a single KV acquisition and deep learning method. Proceedings of SPIE 11312(1131222):None, 2020. PMID: None.
- Li K, Chen GH. Statistical properties of cerebral CT perfusion imaging systems. Part II. Deconvolution-based systems. Med Phys 46(11):4881-4897, 2019. e-Pub 2019. PMID: 31495935.
- Li K, Strother CM, Chen GH. Statistical properties of cerebral CT perfusion imaging systems. Part I. Cerebral blood volume maps generated from nondeconvolution-based systems. Med Phys 46(11):4869-4880, 2019. e-Pub 2019. PMID: 31487396.
- Ji X, Zhang R, Chen GH, Li K. Task-driven optimization of the non-spectral mode of photon counting CT for intracranial hemorrhage assessment. Phys Med Biol 64(21):215014, 2019. e-Pub 2019. PMID: 31509812.
- Li Y, Li K, Zhang C, Montoya J, Chen GH. Learning to Reconstruct Computed Tomography Images Directly From Sinogram Data Under A Variety of Data Acquisition Conditions. IEEE Trans Med Imaging 38(10):2469-2481, 2019. PMID: 30990179.
- Harvey EC, Feng M, Ji X, Zhang R, Li Y, Chen GH, Li K. Impacts of photon counting CT to maximum intensity projection (MIP) images of cerebral CT angiography: theoretical and experimental studies. Phys Med Biol 64(18):185015, 2019. e-Pub 2019. PMID: 31315093.
- Cruz-Bastida JP, Zhang R, Gomez-Cardona D, Hayes J, Li K, Chen GH. Impact of noise reduction schemes on quantitative accuracy of CT numbers. Med Phys 46(7):3013-3024, 2019. e-Pub 2019. PMID: 31004439.
- Ji X, Feng M, Zhang R, Chen GH, Li K. An experimental method to directly measure DQE(k) at k=0 for 2D x-ray imaging systems. Phys Med Biol 64(7):075013-75013, 2019. e-Pub 2019. PMID: 30884472.
- Planz VB, Posielski NM, Lubner MG, Li K, Chen GH, Nakada SY, Pickhardt PJ. Ultra-low-dose limited renal CT for volumetric stone surveillance: advantages over standard unenhanced CT. Abdom Radiol (NY) 44(1):227-233, 2019. PMID: 30073402.
- Garrett JW, Li Y, Li K, Wu Y, Johnson K, Schafer S, Chen GH. Quantification of temporal resolution improvement factor in SMART-RECON based time-resolved C-arm Cone beam computed tomography angiography (TR-CBCTA). Phys Med Biol 63(19):19NT02, 2018. e-Pub 2018. PMID: 30196276.
- Zhang R, Cruz-Bastida JP, Gomez-Cardona D, Hayes JW, Li K, Chen GH. Quantitative accuracy of CT numbers: Theoretical analyses and experimental studies. Med Phys 45(10):4519-4528, 2018. e-Pub 2018. PMID: 30102414.
- Pickhardt PJ, Graffy PM, Reeder SB, Hernando D, Li K. Quantification of Liver Fat Content With Unenhanced MDCT: Phantom and Clinical Correlation With MRI Proton Density Fat Fraction. AJR Am J Roentgenol 211(3):W151-W157, 2018. e-Pub 2018. PMID: 30016142.
- Ji X, Zhang R, Chen GH, Li K. Impact of anti-charge sharing on the zero-frequency detective quantum efficiency of CdTe-based photon counting detector system: cascaded systems analysis and experimental validation. Phys Med Biol 63(9):095003, 2018. e-Pub 2018. PMID: 29582785.
- Garrett JW, Li Y, Li K, Chen GH. Reduced anatomical clutter in digital breast tomosynthesis with statistical iterative reconstruction. Med Phys 45(5):2009-2022, 2018. e-Pub 2018. PMID: 29542821.
- Hayes JW, Gomez-Cardona D, Zhang R, Li K, Cruz-Bastida JP, Chen GH. Low-dose cone-beam CT via raw counts domain low-signal correction schemes: Performance assessment and task-based parameter optimization (Part I: Assessment of spatial resolution and noise performance). Med Phys 45(5):1942-1956, 2018. e-Pub 2018. PMID: 29532483.
- Li Y, Garrett JW, Li K, Wu Y, Johnson K, Schafer S, Strother C, Chen GH. Time-resolved C-arm cone beam CT angiography (TR-CBCTA) imaging from a single short-scan C-arm cone beam CT acquisition with intra-arterial contrast injection. Phys Med Biol 63(7):075001, 2018. e-Pub 2018. PMID: 29494345.
- Ge Y, Ji X, Zhang R, Li K, Chen GH. K-edge energy-based calibration method for photon counting detectors. Phys Med Biol 63(1):015022, 2017. e-Pub 2017. PMID: 29072192.
- Cruz-Bastida JP, Gomez-Cardona D, Garrett J, Szczykutowicz T, Chen GH, Li K. Modified ideal observer model (MIOM) for high-contrast and high-spatial resolution CT imaging tasks. Med Phys 44(9):4496-4505, 2017. e-Pub 2017. PMID: 28600849.
- Ji X, Ge Y, Zhang R, Li K, Chen GH. Studies of signal estimation bias in grating-based x-ray multicontrast imaging. Med Phys 44(6):2453-2465, 2017. e-Pub 2017. PMID: 28339107.
- Pooler BD, Lubner MG, Kim DH, Chen OT, Li K, Chen GH, Pickhardt PJ. Prospective Evaluation of Reduced Dose Computed Tomography for the Detection of Low-Contrast Liver Lesions: Direct Comparison with Concurrent Standard Dose Imaging. Eur Radiol 27(5):2055-2066, 2017. e-Pub 2016. PMID: 27595834.
- Chen Y, Budde A, Li K, Li Y, Hsieh J, Chen GH. A platform-independent method to reduce CT truncation artifacts using discriminative dictionary representations. Med Phys 44(1):121-131, 2017. PMID: 28102942.
- Gomez-Cardona D, Cruz-Bastida JP, Li K, Budde A, Hsieh J, Chen GH. Impact of bowtie filter and object position on the two-dimensional noise power spectrum of a clinical MDCT system. Med Phys 43(8):4495, 2016. PMID: 27487866.
- Bannas P, Li Y, Motosugi U, Li K, Lubner M, Chen GH, Pickhardt PJ. Prior Image Constrained Compressed Sensing Metal Artifact Reduction (PICCS-MAR): 2D and 3D Image Quality Improvement with Hip Prostheses at CT Colonography. Eur Radiol 26(7):2039-46, 2016. e-Pub 2015. PMID: 26521266.
- Cruz-Bastida JP, Gomez-Cardona D, Li K, Sun H, Hsieh J, Szczykutowicz TP, Chen GH. Hi-Res scan mode in clinical MDCT systems: Experimental assessment of spatial resolution performance. Med Phys 43(5):2399, 2016. PMID: 27147351.
- Gomez-Cardona D, Li K, Hsieh J, Lubner MG, Pickhardt PJ, Chen GH. Can conclusions drawn from phantom-based image noise assessments be generalized to in vivo studies for the nonlinear model-based iterative reconstruction method?. Med Phys 43(2):687-95, 2016. PMID: 26843232.
- Gomez-Cardona D, Nagle SK, Li K, Robinson TE, Chen GH. Influence of radiation dose and reconstruction algorithm in MDCT assessment of airway wall thickness: A phantom study. Med Phys 42(10):5919-27, 2015. PMID: 26429266.
- Li K, Gomez-Cardona D, Hsieh J, Lubner MG, Pickhardt PJ, Chen GH. Statistical model based iterative reconstruction in clinical CT systems. Part III. Task-based kV/mAs optimization for radiation dose reduction. Med Phys 42(9):5209-21, 2015. PMID: 26328971.
- Lubner MG, Pooler BD, Kitchin DR, Tang J, Li K, Kim DH, Munoz del Rio A, Chen GH, Pickhardt PJ. Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging. Eur Radiol 25(7):2089-102, 2015. e-Pub 2015. PMID: 25903700.
- Li K, Garrett J, Ge Y, Chen GH. Statistical model based iterative reconstruction (MBIR) in clinical CT systems. Part II. Experimental assessment of spatial resolution performance. Med Phys 41(7):071911, 2014. PMID: 24989389.
- Li K, Ge Y, Garrett J, Bevins N, Zambelli J, Chen GH. Grating-based phase contrast tomosynthesis imaging: proof-of-concept experimental studies. Med Phys 41(1):011903, 2014. PMID: 24387511.
- Li K, Garrett J, Chen GH. Correlation between human observer performance and model observer performance in differential phase contrast CT. Med Phys 40(11):111905, 2013. PMID: 24320438.
- Li K, Zambelli J, Bevins N, Ge Y, Chen GH. Spatial resolution characterization of differential phase contrast CT systems via modulation transfer function (MTF) measurements. Phys Med Biol 58(12):4119-35, 2013. e-Pub 2013. PMID: 23685949.
- Li K, Bevins N, Zambelli J, Chen GH. Fundamental relationship between the noise properties of grating-based differential phase contrast CT and absorption CT: theoretical framework using a cascaded system model and experimental validation. Med Phys 40(2):021908, 2013. PMID: 23387756.
- Bevins N, Zambelli J, Li K, Qi Z, Chen GH. Multicontrast x-ray computed tomography imaging using Talbot-Lau interferometry without phase stepping. Med Phys 39(1):424-8, 2012. PMID: 22225312.
- Chen GH, Zambelli J, Li K, Bevins N, Qi Z. Scaling law for noise variance and spatial resolution in differential phase contrast computed tomography. Med Phys 38(2):584-8, 2011. PMID: 21452695.
- Chen GH, Zambelli J, Bevins N, Qi Z, Li K. X-ray phase sensitive imaging methods: basic physical principles and potential medical applications. Curr Med Imaging Rev 6(2):90-99, 2010. PMID: 23970846.
Book Chapters
- Li K, Chen GH. CT Image Quality Characterization. In: Computed Tomography: New Approaches, Applications, and Operators. None. Springer, 85-124, 2020.
- Li K, Chen GH. Chapter 52: X-ray Phase Contrast Tomosynthesis Imaging. In: Handbook of X-Ray Imaging. None. None, None, 2018.
Selected Presentations & Talks
Local Presentations
- 2023. The Facts about Photon Counting CT. Invited. Radiology Grand Round. Madison, Wisconsin, US.
- 2022. The Essence of Photon Counting Imaging and Its Potential Benefits in Image-Guided Interventions. Invited. Department of Medical Physics Seminar. Madison, Wisconsin, US.
- 2014. CT Protocol Optimization at the Dawn of Iterative Reconstruction: Maximizing Diagnostic Performance and Minimizing Radiation Dose. Invited. Madison, Wisconsin, US.
Regional Presentations
- 2023. The Essence of Photon Counting X-ray Imaging and Its Benefits to Neuro Interventions. Invited. AAPM North Central Chapter 2023 Spring Meeting. Bloomington, Minnesota, US.
National Presentations
- 2023. Basic Principles of Photon Counting Detectors for CT Imaging. Invited. RSNA Annual Meeting. Chicago, Illinois, US.
- 2023. Practical Implementation of Photon Counting Detection for C-arm Cone Beam CT Imaging. Invited. AAPM Annual Meeting. Houston, Texas, US.
- 2023. Keynote Presentation: Spectral CT as a Clinical Problem Solver. Invited. RSNA Annual Meeting. Chicago, Illinois, US.
- 2023. Hybrid Detector Systems for Neuro Interventions. Invited. IGCT Seminar. Houston, Texas, US.
- 2022. Bringing Photon Counting Detectors to the Interventional Room. Invited. AAPM Annual Meeting. Washington DC, US.
- 2022. Quantitative lung perfusion blood volume maps using effective Z images learned from single-kV pulmonary CT angiography data. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2021. Pulmonary Z-score: A New CT Imaging Biomarker for Quantifying Pulmonary Perfusion Defects. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2021. Improving Intraoperative Visualization of Arterial Branching Pattern Using A High Spatial Resolution C -arm Photon Counting Detector CT System. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2021. Learning Quantitative Pulmonary Perfusion Images from Single-kV Pulmonary CT Angiography Data. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2020. Impacts of pulse pileup, charge sharing, and anti-charge sharing on the noise power spectra of photon counting detectors: theoretical analysis and experimental demonstrations. Conference. SPIE Medical Imaging Conference. Houston, TX, US.
- 2020. Analogous Lubberts effect in photon counting detectors. Conference. SPIE Medical Imaging Conference. Houston, TX, US.
- 2018. Multi-Contrast X-Ray Breast Imaging Prototype System. Invited. AAPM Annual Meeting. Nashville, Tennessee, US.
- 2018. Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system. Conference. SPIE Medical Imaging Conference. Houston, TX, US.
- 2017. Dependence of quantitative accuracy of CT perfusion imaging on system parameters. Conference. SPIE Medical Imaging Conference. Orlando, FL, US.
- 2017. Phase-Contrast Imaging of the Breast with Photon-Counting Detectors. Invited. AAPM Annual Meeting. Denver, Colorado, US.
- 2016. Noise characteristics of CT perfusion imaging: How does noise propagate from source images to final perfusion maps?. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2016. Quantitative Assessment of CT Systems with Iterative Image Reconstruction Algorithms. Invited. AAPM Annual Meeting. Washington DC, US.
- 2016. Four-dimensional cascaded systems analysis of cerebral CT perfusion imaging: Theoretical framework and applications. Invited. Baltimore, Maryland, US.
- 2016. Platform-Independent Method to Reduce CT Truncation Artifacts. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2016. Sub-mSv Cerebral CT Perfusion Imaging using Prior Image Constrained Compressed Sensing: A Prospective Clinical Trial. Conference. AAPM Annual Meeting. Washington, DC, US.
- 2016. Sub-mSv Cerebral CT Perfusion Imaging using Prior Image Constrained Compressed Sensing: A Prospective Comparison of Image Quality at Reduced Dose versus Standard Dose Imaging. Conference. American Society of Neuroradiology (ASNR) Annual Meeting Washington, DC. Washington, DC, US.
- 2015. Clinical Applications of X-Ray Phase Contrast Imaging: Where Do We Stand?. Invited. AAPM Annual Meeting. Anaheim, California, US.
- 2015. A Task-Driven Parameter Optimization Method for Cerebral CT Perfusion Imaging. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2015. Imaging task-based optimal kV and mA selection for CT radiation dose reduction: from filtered backprojection (FBP) to statistical model based iterative reconstruction (MBIR). Conference. SPIE Medical Imaging Conference. Orlando, FL, US.
- 2015. A Novel Tube Current Modulation Scheme in CT Perfusion Imaging to Reduce Radiation Dose and Improve Image Quality. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2015. High Quality and Sub-mSv Cerebral CT Perfusion Imaging. Conference. AAPM Annual Meeting. Anaheim, CA, US.
- 2015. Task-Driven Cerebral CT Perfusion Imaging. Conference. AAPM Annual Meeting. Anaheim, CA, US.
- 2014. Noise performance of statistical model based iterative reconstruction in clinical CT systems. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2014. Experimental assessment of z- and axial spatial resolution of statistical model based iterative reconstruction and its correlation with image noise. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2014. Impact of Patient Positioning on CT Image Quality: With and without Model Based Statistical Image Reconstruction Method. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2014. Statistical Model Based Iterative Reconstruction (MBIR) in Clinical CT Systems: Experimental Assessment of Z- and Axial Spatial Resolution. Conference. AAPM Annual Meeting. Austin, TX, US.
- 2014. Is Automatic Tube Current Modulation Still Necessary with Statistical Iterative Reconstruction?. Conference. AAPM Annual Meeting. Austin, TX, US.
- 2013. Experimental measurement of the modulation transfer function of differential phase contrast CT Systems. Conference. SPIE Medical Imaging Conference. Orlando, FL, US.
- 2013. Model observer and human observer performance studies in differential phase contrast CT. Conference. SPIE Medical Imaging Conference. Orlando, FL, US.
- 2013. How to determine detection performance of a DPC-CT system from a conventional cone beam CT system?. Conference. SPIE Medical Imaging Conference. Orlando, FL, US.
- 2013. The Feasibility of An X‐Ray Differential Phase Contrast Tomosynthesis System Adapted from a Clinical Digital Breast Tomosynthesis System. Conference. AAPM Annual Meeting. Indianapolis, IN, US.
- 2013. X-ray Differential Phase Contrast Tomosynthesis Imaging based on a Clinical Digital Breast Tomosynthesis System. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2013. A Novel Implementation of X-ray Differential Phase Contrast CT Imaging without Talbot-Lau Interferometer: Principles and In Vivo Animal Studies. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2012. Human Observer Performance Studies of X-ray Differential Phase Contrast CT. Conference. RSNA Annual Meeting. Chicago, IL, US.
- 2012. Detection performance study for cone-beam differential phase contrast CT. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2012. A new image reconstruction method to improve noise properties in x-ray differential phase contrast computed tomography. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2012. Differential phase contrast tomosynthesis imaging. Conference. SPIE Medical Imaging Conference. San Diego, CA, US.
- 2011. Performance Study of Regularized Phase Retrieval from X-Ray Differential Phase Contrast Projection Image. Conference. AAPM Annual Meeting. Vancouver, CA.
International Presentations
- 2019. Application of Photon Counting CT in Neuro Imaging. Invited. Nanjing, CN.
- 2019. A general theory of x-ray grating interferometer with arbitrary grating combination. Invited. Nanjing, CN.
- 2017. Task-Based Radiation Dose Optimization in Cerebral CT Perfusion Imaging. Conference. Xi'an, CN.
- 2017. First results from an x-ray dark field breast tomosynthesis prototype system. Conference. The 4th International Conference on X-ray and Neutron Phase Imaging with Gratings. Zurich, CH.
- 2017. X-Ray Dark Field Tomosynthesis Imaging.”. Conference. Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine. Xi'an, CN.
Grant & Contract Support
| Title: | On-board Photon Counting Detector Cone Beam CT-guided Proton Therapy |
| Funding Source: | University of Wisconsin-Madison Vilas Associate Competition Award |
| Role: | PI |
| Title: | Next Generation Cone Beam CT with Improved Contrast Resolution and Added Spectral Imaging Functionality |
| Funding Source: | NIH |
| Role: | Co-I |
| Title: | Collaborative CT Physics Research Program |
| Funding Source: | GE Healthcare |
| Role: | Co-I |
| Title: | Clinical Translation of a One-Stop-Shop Imaging Method for Abdominal CT Applications |
| Funding Source: | NIH |
| Role: | Co-I |
| Title: | Functional Lung Imaging Using a Single kV CT Acquisition |
| Funding Source: | NIH |
| Role: | PI |
| Title: | Development and Deployment of Artificial Intelligence (AI) Driven Methods to Enable Chest X-ray Radiography as a Diagnostic Method for COVID-19 Pneumonia |
| Funding Source: | NIH |
| Role: | Co-I |
| Title: | Multi-Contrast Chest Radiography (MC-CXR) for COVID-19 Diagnosis and Screening |
| Funding Source: | NIH |
| Role: | PI |
| Title: | Alternative Means to Diagnose COVID-19 Pneumonia |
| Funding Source: | Wisconsin Partnership Program |
| Role: | Co-I |
| Title: | Trimodal Mammography with Perfect Co-registration |
| Funding Source: | Department of Defense Breast Cancer Research Program |
| Role: | PI |
| Title: | Multi-Contrast X-Ray Breast Imaging |
| Funding Source: | NIH |
| Role: | PI |
| Title: | One Stop Shop Imaging for Acute Ischemic Stroke Treatment |
| Funding Source: | NIH |
| Role: | Co-I |
| Title: | High Quality and Sub-mSv Cerebral CT Perfusion Imaging |
| Funding Source: | AAPM Research Seed Fund |
| Role: | PI |
Patient Reviews
CV information above last modified January 03, 2025