Kevin M. McBride, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Basic Science Research, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Smithville, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Basic Science Research, The University of Texas MD Anderson Cancer Center, Smithville, TX
Member, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX
Research Interests
.
Education & Training
Degree-Granting Education
| 2000 | Stony Brook University, Stony Brook, New York, US, Molecular and Cellular Pathology, Ph.D |
| 1994 | Worcester Polytechnic Institute, Worcester, Massachusetts, US, Biotechnology, BS |
Postgraduate Training
| 2007-2011 | Research Associate, Rockefeller University, New York, New York |
| 2002-2007 | Postdoctoral Fellow, Rockefeller University, New York, New York |
| 2001-2002 | Postdoctoral Associate, Stony Brook University, Stony Brook, New York |
Experience & Service
Academic Appointments
Assistant Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2011 - 2018
Administrative Appointments/Responsibilities
Director: Recombinant Antibody Production Core, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2018 - Present
Associate Director: Science Park Summer Undergraduate Research Program in Cancer, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2014 - 2021
Other Appointments/Responsibilities
Senator, UTMDACC, Houston, TX, 2021 - 2024
Member, Center for Molecular & Cellular Toxicology, Austin, TX, 2013 - Present
Institutional Committee Activities
Member, Institutional Committee, 2024 - Present
Member, EMC Department Chair Search Advisory Committee, 2023 - 2023
Member, CPRIT Graduate Scholar Selection Committee, 2023 - Present
Member, Institutional UTMDACC Research Misconduct Committee, 2023 - Present
Member, CCSG Development Therapeutics Program -- Brainstorming Retreat, 2022 - 2022
Member, Advisory Committee for Breeder Animal Movement, UTMDACC, 2020 - 2020
Member, TMC3 Vivarium Think Tank, UTMDACC, 2020 - 2020
Member, TMC3 Think Tank, UTMDACC, 2020 - 2020
Member, Kopchick Research Award Review Committee, 2018 - 2020
Member, Genetics and Epigenetics Program Community Committee, GSBS, 2018 - Present
Member, Recruitment Committee, Genetics and Epigenetic Program, 2017 - Present
Member, Department of Epigenetics and Molecular Carcinogenesis Faculty Search Committee, 2016 - 2017
Member, Steering Committee, Epigenetics and Molecular Carcinogenesis Program, 2015 - 2017
Member, Postdoctoral Advisory Committee, 2014 - 2017
Member, Faculty Academic Review Committee (FARC), 2014 - Present
Member, Admissions Committee, Epigenetics and Molecular Carcinogenesis Program, 2013 - 2017
Member, Graduate School of Biomedical Science (GSBS) Student Scholarship Committee, 2012 - 2016
Member, Department of Molecular Carcinogenesis Faculty Search Committee, 2012 - 2012
Member, Faculty Senator, 2012 - 2015
Honors & Awards
| 2013 | MD Anderson Cancer Center, Leukemia SPORE Career Development Award, The University of Texas MD Anderson Cancer Center |
| 2011 | University of Texas Systems, STARS Recruitment Award, University of Texas Systems |
| 2003 | NIH Postdoctoral Training Fellowship |
| 2002 | Aaron Janoff award for excellence in experimental pathology, Stony Brook University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Marshall VA, Cornejo Castro EM, Goodman CA, Labo N, Liu I, Fisher NC, Moore KN, Nair A, Immonen T, Keele BF, Polizzotto MN, Uldrick TS, Mu Y, Saswat T, Krug LT, McBride KM, Lurain K, Ramaswami R, Yarchoan R, Whitby D. Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance. PLoS Pathog 20(7):e1012338, 2024. e-Pub 2024. PMID: 39008527.
- Mu Y, Chen Z, Plummer JB, Zelazowska MA, Dong Q, Krug LT, McBride KM. UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair. bioRxiv, 2024. e-Pub 2024. PMID: 38746347.
- Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio 15(2):e0299823, 2024. e-Pub 2024. PMID: 38170993.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Author Correction: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol 21(1):100, 2024. e-Pub 2024. PMID: 38114748.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24. Cell Mol Immunol 20(12):1487-1498, 2023. e-Pub 2023. PMID: 37990035.
- Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. mSphere 8(5):e0027823, 2023. e-Pub 2023. PMID: 37747202.
- Mu Y, Zelazowska MA, Chen Z, Plummer JB, Dong Q, Krug LT, McBride KM. Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. DNA Repair (Amst) 128:103515, 2023. e-Pub 2023. PMID: 37315375.
- Liu KJ, Zelazowska MA, McBride KM. The Longitudinal Analysis of Convergent Antibody VDJ Regions in SARS-CoV-2-Positive Patients Using RNA-Seq. Viruses 15(6), 2023. e-Pub 2023. PMID: 37376553.
- Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues. bioRxiv, 2023. e-Pub 2023. PMID: 37398059.
- Mu Y, Plummer JB, Zelazowska MA, Paul S, Dong Q, Chen Z, Krug LT, McBride KM. A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression. bioRxiv, 2023. e-Pub 2023. PMID: 37293087.
- Hogan CH, Owens SM, Reynoso GV, Kirillov V, Meyer TJ, Zelazowska MA, Liu B, Li X, Chikhalya A, Dong Q, Khairallah C, Reich NC, Sheridan B, McBride KM, Hearing P, Hickman HD, Forrest JC, Krug LT. B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model. bioRxiv, 2023. e-Pub 2023. PMID: 36993230.
- Ying Z, Hardikar S, Plummer JB, Hamidi T, Liu B, Chen Y, Shen J, Mu Y, McBride KM, Chen T. Characterization of a mouse model of ICF syndrome reveals enhanced CD19 activation in inducing hypogammaglobulinemia. bioRxiv, 2023. e-Pub 2023. PMID: 36945532.
- Farria AT, Plummer JB, Salinger AP, Shen J, Lin K, Lu Y, McBride KM, Koutelou E, Dent SYR. Transcriptional activation of Myc-induced genes by Gcn5 promotes B cell lymphomagenesis. Cancer Res 80(24):5543-5553, 2020. e-Pub 2020. PMID: 33168647.
- Hwang T, Reh S, Dunbayev Y, Zhong Y, Takata Y, Shen J, McBride KM, Murnane JP, Bhak J, Lee S, Wood RD, Takata KI. Defining the mutation signatures of DNA polymerase θ in cancer genomes. NAR Cancer 2(3):https://academic.oup.com/narcancer/article/2/3/zcaa017/5898153, 2020. e-Pub 2020. PMID: 32885167.
- Zelazowska, MA, McBride, KM, Krug, LT. Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire. Viruses 12(8):788, 2020. e-Pub 2020.
- Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell 11(3):214-218, 2020. e-Pub 2020. PMID: 31970665.
- Zelazowska MA, Dong Q, Plummer JB, Zhong Y, Liu B, Krug LT, McBride KM. Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire. Life Sci Alliance 3(3), 2020. e-Pub 2020. PMID: 32029571.
- Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Sautès-Fridman C, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA. B-cells and tertiary lymphoid structures promote immunotherapy response. Nature 577(7791):549-555, 2020. e-Pub 2020. PMID: 31942075.
- McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in mouse B Cells leads to genomic instability, neoplastic transformation and monoclonal gammopathies. Front Oncol 9:517, 2019. e-Pub 2019. PMID: 31275852.
- Dong Q, Smith KR, Oldenburg DG, Shapiro M, Schutt WR, Malik L, Plummer JB, Mu Y, MacCarthy T, White DW, McBride KM, Krug LT. Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. MBio 9(5), 2018. e-Pub 2018. PMID: 30377280.
- Mu Y, McBride KM. Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association. Mol Cell Oncol 5(5):e1432259, 2018. e-Pub 2018. PMID: 30263937.
- Mu Y, Zelazowska MA, McBride KM. Phosphorylation Promotes Activation-Induced Cytidine Deaminase Activity at the Myc Oncogene. J Exp Med 214(12):3543-3552, 2017. e-Pub 2017. PMID: 29122947.
- Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet 13(6):e1006818, 2017. e-Pub 2017. PMID: 28570559.
- Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1. ACS Chem Biol 10(4):1072-81, 2015. e-Pub 2015. PMID: 25590533.
- Kracker S, Di Virgilio M, Schwartzentruber J, Cuenin C, Forveille M, Deau MC, McBride KM, Majewski J, Gazumyan A, Seneviratne S, Grimbacher B, Kutukculer N, Herceg Z, Cavazzana M, Jabado N, Nussenzweig MC, Fischer A, Durandy A. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol 135(4):998-1007.e6, 2015. e-Pub 2015. PMID: 25312759.
- Minkah N, Macaluso M, Oldenburg DG, Paden CR, White DW, McBride KM, Krug LT. Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo. J Virol 89(6):3366-79, 2015. e-Pub 2015. PMID: 25589640.
Selected Presentations & Talks
Formal Peers
- 2022. HIV and AIDS Malignancy Branch (HAMB). Invited. HIV and AIDS Malignancy Branch (HAMB), US.
- 2019. The University of Texas at Austin. Invited. 8888. Austin, TX, US.
- 2018. Baylor College of Medicine. Invited. 8888. Houston, TX, US.
- 2018. German Cancer Research Center (DKFZ). Invited. Unknown. Heidelberg, DE.
- 2013. Stony Brook University. Invited. Unknown. Stony Brook, NY, US.
- 2012. Dell Pediatric Research Institute. Invited. Dell Pediatric Research Institute. Austin, TX, US.
Grant & Contract Support
| Date: | 2025 - 2026 |
| Title: | Harnessing tertiary lymphoid structure function for improved immunotherapeutic strategies in cancer patients |
| Funding Source: | The Mark Foundation for Cancer Research |
| Role: | Co-PI |
| ID: | EDV-0000000268-EXT |
| Date: | 2024 - 2025 |
| Title: | Investigating Common Antibodies Generated Against Surface Targets in Patients Undergoing Immune Checkpoint Blockade Therapy |
| Funding Source: | Institutional Research Grant (IRG), The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | 2024-00064003-Y1 |
| Date: | 2024 - 2026 |
| Title: | A somatic hypermutation defective UNG mutant in antibody deficiency through destabilization of RPA interaction |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R03AI175719-01A1 |
| Date: | 2023 - 2025 |
| Title: | Development of Therapeutic Binders for Novel Targets SRA1 |
| Funding Source: | Manaolana Oncology Limited |
| Role: | Co-PI |
| ID: | LS2023-00062749-MT |
| Date: | 2022 - 2026 |
| Title: | Harnessing tertiary lymphoid structure function for improved immunotherapeutic strategies in cancer patients |
| Funding Source: | The Mark Foundation for Cancer Research/The University of Pittsburgh |
| Role: | Co-PI |
| ID: | EDV-0000000268 |
| Date: | 2017 - Present |
| Title: | Three Strohm Sisters Family Foundation |
| Funding Source: | Three Strohm Sisters Family Foundation |
| Role: | PI |
| ID: | N/A |
Patient Reviews
CV information above last modified March 31, 2025