Kevin T. Nead, M.D., MPhil

Peer-Reviewed Articles

1. Grasso C, Popovic M, Isaevska E, Lazzarato F, Fiano V, Zugna D, Pluta J, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Bishop DT, Chanock SJ, Chen C, Cortessis VK, Dalgaard MD, Daneshmand S, Ferlin A, Foresta C, Frone MN, Gamulin M, Gietema JA, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Karlsson R, Kiemeney LA, Lessel D, Lista P, Lothe RA, Loveday C, Meijer C, Nead KT, Nsengimana J, Skotheim RI, Turnbull C, Vaughn DJ, Wiklund F, Zheng T, Zitella A, Schwartz SM, McGlynn KA, Kanetsky PA, Nathanson KL, Richiardi L. Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk. Cancer Epidemiol Biomarkers Prev 31(9):1769-1779, 2022. PMID: 35700037.
2. Nead KT, Hinkston CL, MacKenzie RW,. Cautions When Using Race and Ethnicity in Administrative Claims Data Sets. JAMA Health Forum 3(7):221812, 2022.
3. Koutroumpakis E, Deswal A, Yusuf SW, Abe JI, Nead KT, Potter AS, Liao Z, Lin SH, Palaskas NL. Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment. Curr Oncol Rep 24(5):543-553, 2022. e-Pub 2022. PMID: 35192118.
4. Carey RM, Kim T, Cohen NA, Lee RJ, Nead KT. Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival. Sci Rep 12(1):8937, 2022. e-Pub 2022. PMID: 35624283.
5. Nowakowska MK, Kim T, Thompson MT, Bolton KL, Deswal A, Lin SH, Scheet P, Wehner MR, Nead KT. Association of clonal hematopoiesis mutations with clinical outcomes: a systematic review and meta-analysis. Am J Hematol 97(4):411-420, 2022. e-Pub 2022. PMID: 35015316.
6. Wang X, Palaskas NL, Hobbs BP, Abe JI, Nead KT, Yusuf SW, Hermann J, Deswal A, Lin SH. The Impact of Radiation Dose to Heart Substructures on Major Coronary Events and Patient Survival after Chemoradiation Therapy for Esophageal Cancer. Cancers (Basel) 14(5), 2022. e-Pub 2022. PMID: 35267613.
7. Corrigan KL, Lei X, Ahmad N, Arzu I, Bloom E, Chun SG, Goodman C, Hoffman KE, Joyner M, Mayo L, Mitchell M, Nead KT, Perkins GH, Reed V, Reddy JP, Schlembach P, Shaitelman SF, Stauder MC, Strom EA, Tereffe W, Wiederhold L, Woodward WA, Smith BD. Adoption of Ultrahypofractionated Radiation Therapy in Patients With Breast Cancer. Adv Radiat Oncol 7(2):100877, 2022. e-Pub 2021. PMID: 35387420.
8. Sosa A, Lei X, Woodward WA, Chavez Mac Gregor M, Lucci A, Giordano SH, Nead KT. Trends in Sentinel Lymph Node Biopsies in Patients With Inflammatory Breast Cancer in the US. JAMA Netw Open 5(2):e2148021, 2022. e-Pub 2022. PMID: 35147686.
9. Diao K, Andring LM, Barcenas CH, Singh P, Carisa Le-Petross H, Reed VK, Reddy JP, Bloom ES, Ahmad NR, Mayo LL, Perkins GH, Mitchell MP, Nead KT, Tereffe W, Smith BD, Woodward WA. Contemporary Outcomes After Multimodality Therapy in Patients with Breast Cancer Presenting With Ipsilateral Supraclavicular Node Involvement. Int J Radiat Oncol Biol Phys 112(1):66-74, 2022. e-Pub 2021. PMID: 34710521.
10. Nowakowska MK, Lei X, Wehner MR, Corn PG, Giordano SH, Nead KT. Association of Second-generation Antiandrogens with Depression Among Patients With Prostate Cancer. JAMA Netw Open 4(12):e2140803, 2021. e-Pub 2021. PMID: 34940861.
11. Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Benitez J, Brown CD, Chanock S, Chen C, Cortessis VK, Ferlin A, Foresta C, Gamulin M, Gietema JA, Grasso C, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Hildebrandt MAT, Johnson ME, Karlsson R, Kiemeney LA, Lessel D, Lothe RA, Loud JT, Loveday C, Martin-Gimeno P, Meijer C, Nsengimana J, Quinn DI, Rafnar T, Ramdas S, Richiardi L, Skotheim RI, Stefansson K, Turnbull C, Vaughn DJ, Wiklund F, Wu X, Yang D, Zheng T, Wells AD, Grant SFA, Rajpert-De Meyts E, Schwartz SM, Bishop DT, McGlynn KA, Kanetsky PA, Nathanson KL, Testicular Cancer Consortium. Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nat Commun 12(1):4487, 2021. e-Pub 2021. PMID: 34301922.
12. Batra A, Marchioni M, Hashmi AZ, Lonergan PE, Morgans AK, Nead KT, Nguyen PL, Winquist E, Chin JL. Depression and cognitive effects of androgen receptor axis-targeted drugs in men with prostate cancer: A systematic review. J Geriatr Oncol 12(5):687-695, 2021. e-Pub 2020. PMID: 33234494.
13. Rahib L, Wehner MR, Matrisian LM, Nead KT. Estimated Projection of US Cancer Incidence and Death to 2040. JAMA Netw Open 4(4):e214708, 2021. e-Pub 2021. PMID: 33825840.
14. Thompson MR, Niu J, Lei X, Nowakowska M, Wehner MR, Giordano SH, Nead KT. Association of Endocrine Therapy and Dementia in Women with Breast Cancer. Breast Cancer (Dove Med Press) 13:219-224, 2021. e-Pub 2021. PMID: 33854369.
15. Wehner MR, Li Y, Nead KT. Comparison of the Proportions of Female and Male Corresponding Authors in Preprint Research Repositories Before and During the COVID-19 Pandemic. JAMA Netw Open 3(9):e2020335, 2020. e-Pub 2020. PMID: 32940678.
16. Jain V, Hwang WT, Venigalla S, Nead KT, Lukens JN, Mitchell TC, Shabason JE. Association of Age with Efficacy of Immunotherapy in Metastatic Melanoma. Oncologist 25(2):e381-e385, 2020. e-Pub 2019. PMID: 32043765.
17. Stjepanovicaj N, Villacampaa G, Nead KT, Esquius ST, Melis GG, Nathanson KL, Teule A, Brunet J, y Cajal TR, Llort G, Dienstmann R, Rue M, Domchek SM, Balmana J. Association of premenopausal risk-reducing salpingo-oophorectomy with breast cancer risk in BRCA1/2 mutation carriers: Maximising bias-reduction. European Journal of Cancer 132:53-60, 2020.
18. Nead KT, Mitra N, Weathers B, Pyle L, Emechebe N, Pucci DA, Jacobs LA, Vaughn DJ, Nathanson KL, Kanetsky PA. Lower abdominal and pelvic radiation and testicular germ cell tumor risk. PLoS One 15(11):e0239321, 2020. e-Pub 2020. PMID: 33175879.
19. Nead KT, Linos E, Vapiwala N. Increasing Diversity in Radiation Oncology: A Call to Action. Adv Radiat Oncol 4(2):226-228, 2019. e-Pub 2018. PMID: 31011665.
20. Nead KT, Swisher-McClure S. Utilization of hypofractionated radiation therapy in older glioblastoma patients. J Geriatr Oncol 10(1):155-158, 2019. e-Pub 2018. PMID: 30017732.
21. Nead KT, Wehner MR, Mitra N. The Use of "Trend" Statements to Describe Statistically Nonsignificant Results in the Oncology Literature. JAMA Oncol 4(12):1778-1779, 2018. PMID: 30347042.
22. Nead KT, Boldbaatar N, Yang DD, Sinha S, Nguyen PL. Association of Androgen Deprivation Therapy and Thromboembolic Events: A Systematic Review and Meta-analysis. Urology 114:155-162, 2018. e-Pub 2018. PMID: 29352986.
23. Venigalla S, Nead KT, Sebro R, Guttmann DM, Sharma S, Simone CB, Levin WP, Wilson RJ, Weber KL, Shabason JE. Association Between Treatment at High-Volume Facilities and Improved Overall Survival in Soft Tissue Sarcomas. Int J Radiat Oncol Biol Phys 100(4):1004-1015, 2018. e-Pub 2017. PMID: 29485042.
24. Yang DD, Krasnova A, Nead KT, Choueiri TK, Hu JC, Hoffman KE, Yu JB, Spratt DE, Feng FY, Trinh QD, Nguyen PL. Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer. Ann Oncol 29(2):386-391, 2018. PMID: 29267861.
25. Nead KT, Sinha S, Yang DD, Nguyen PL. Association of androgen deprivation therapy and depression in the treatment of prostate cancer: A systematic review and meta-analysis. Urol Oncol 35(11):664.e1-664.e9, 2017. e-Pub 2017. PMID: 28803700.
26. Vainshelboim B, Chen Z, Lee YN, Sorayya A, Kokkinos P, Nead KT, Chester C, Myers J. Cardiorespiratory Fitness, Adiposity, and Cancer Mortality in Men. Obesity (Silver Spring) 25 Suppl 2:S66-S71, 2017. PMID: 29086513.
27. Dinh KT, Yang DD, Nead KT, Reznor G, Trinh QD, Nguyen PL. Association between androgen deprivation therapy and anxiety among 78 000 patients with localized prostate cancer. Int J Urol 24(10):743-748, 2017. e-Pub 2017. PMID: 28734019.
28. Nead KT, Sinha S, Nguyen PL. Androgen deprivation therapy for prostate cancer and dementia risk: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 20(3):259-264, 2017. e-Pub 2017. PMID: 28349979.
29. Wehner MR, Nead KT, Linos E. Correlation Among Cancer Incidence and Mortality Rates and Internet Searches in the United States. JAMA Dermatol 153(9):911-914, 2017. PMID: 28658470.
30. Wehner MR, Nead KT, Lipoff JB. Association Between Gender and Drug Cost for Over-the-Counter Minoxidil. JAMA Dermatol 153(8):825-826, 2017. PMID: 28593214.
31. Vainshelboim B, Müller J, Lima RM, Nead KT, Chester C, Chan K, Kokkinos P, Myers J. Cardiorespiratory fitness, physical activity and cancer mortality in men. Prev Med 100:89-94, 2017. e-Pub 2017. PMID: 28412186.
32. Vainshelboim B, Müller J, Lima RM, Nead KT, Chester C, Chan K, Kokkinos P, Myers J. Cardiorespiratory fitness and cancer incidence in men. Ann Epidemiol 27(7):442-447, 2017. e-Pub 2017. PMID: 28789775.
33. Nead KT, Gaskin G, Chester C, Swisher-McClure S, Leeper NJ, Shah NH. Association Between Androgen Deprivation Therapy and Risk of Dementia. JAMA Oncol 3(1):49-55, 2017. PMID: 27737437.
34. Ross EG, Shah NH, Dalman RL, Nead KT, Cooke JP, Leeper NJ. The use of machine learning for the identification of peripheral artery disease and future mortality risk. J Vasc Surg 64(5):1515-1522.e3, 2016. e-Pub 2016. PMID: 27266594.
35. Nead KT, Gaskin G, Chester C, Swisher-McClure S, Dudley JT, Leeper NJ, Shah NH. Influence of age on androgen deprivation therapy-associated Alzheimer's disease. Sci Rep 6:35695, 2016. e-Pub 2016. PMID: 27752112.
36. Yam C, Landsburg DJ, Nead KT, Lin X, Mato AR, Svoboda J, Loren AW, Frey NV, Stadtmauer EA, Porter DL, Schuster SJ, Nasta SD. Autologous stem cell transplantation in first complete remission may not extend progression-free survival in patients with peripheral T cell lymphomas. Am J Hematol 91(7):672-6, 2016. e-Pub 2016. PMID: 27012928.
37. Nead KT, Gaskin G, Chester C, Swisher-McClure S, Dudley JT, Leeper NJ, Shah NH. Androgen Deprivation Therapy and Future Alzheimer's Disease Risk. J Clin Oncol 34(6):566-71, 2016. e-Pub 2015. PMID: 26644522.
38. Nanda V, Downing KP, Ye J, Xiao S, Kojima Y, Spin JM, DiRenzo D, Nead KT, Connolly AJ, Dandona S, Perisic L, Hedin U, Maegdefessel L, Dalman J, Guo L, Zhao X, Kolodgie FD, Virmani R, Davis HR, Leeper NJ. CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels. Circ Res 118(2):230-40, 2016. e-Pub 2015. PMID: 26596284.
39. Wehner MR, Nead KT (co-first author), Linos K, Linos E. Plenty of moustaches but not enough women: cross sectional study of medical leaders. BMJ 351:h6311, 2015. e-Pub 2015. PMID: 26673637.
40. Nead KT, Sharp SJ, Thompson DJ, Painter JN, Savage DB, Semple RK, Barker A, Australian National Endometrial Cancer Study Group (ANECS), Perry JR, Attia J, Dunning AM, Easton DF, Holliday E, Lotta LA, O'Mara T, McEvoy M, Pharoah PD, Scott RJ, Spurdle AB, Langenberg C, Wareham NJ, Scott RA. Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis. J Natl Cancer Inst 107(9), 2015. e-Pub 2015. PMID: 26134033.
41. Ghebremariam YT, Cooke JP, Khan F, Thakker RN, Chang P, Shah NH, Nead KT, Leeper NJ. Proton pump inhibitors and vascular function: A prospective cross-over pilot study. Vasc Med 20(4):309-16, 2015. e-Pub 2015. PMID: 25835348.
42. Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, den Hoed M, Khaw KT, Kilpeläinen TO, Wareham N, Edwards TL, Hallmans G, Varga TV, Kardia SL, Smith JA, Zhao W, Faul JD, Weir D, Mi J, Xi B, Quinteros SC, Cooper C, Sayer AA, Jameson K, Grøntved A, Fornage M, Sidney S, Hanis CL, Highland HM, Häring HU, Heni M, Lasky-Su J, Weiss ST, Gerhard GS, Still C, Melka MM, Pausova Z, Paus T, Grant SF, Hakonarson H, Price RA, Wang K, Scherag A, Hebebrand J, Hinney A, BioBank Japan, AGEN-BMI, GIANT Consortium, Franks PW, Frayling TM, McCarthy MI, Hirschhorn JN, Loos RJ, Ingelsson E, Gerstein HC, Yusuf S, Beyene J, Anand SS, Meyre D. Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Hum Mol Genet 24(12):3582-94, 2015. e-Pub 2015. PMID: 25784503.
43. Myers J, Nead KT, Chang P, Abella J, Kokkinos P, Leeper NJ. Improved reclassification of mortality risk by assessment of physical activity in patients referred for exercise testing. Am J Med 128(4):396-402, 2015. e-Pub 2014. PMID: 25511076.
44. Chang P, Nead KT, Olin JW, Myers J, Cooke JP, Leeper NJ. Effect of physical activity assessment on prognostication for peripheral artery disease and mortality. Mayo Clin Proc 90(3):339-45, 2015. e-Pub 2015. PMID: 25649965.
45. Shah NH, LePendu P, Bauer-Mehren A, Ghebremariam YT, Iyer SV, Marcus J, Nead KT, Cooke JP, Leeper NJ. Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PLoS One 10(6):e0124653, 2015. e-Pub 2015. PMID: 26061035.
46. Chang P, Nead KT (co-first author), Olin JW, Cooke JP, Leeper NJ. Clinical and socioeconomic factors associated with unrecognized peripheral artery disease. Vasc Med 19(4):289-296, 2014. e-Pub 2014. PMID: 24872403.
47. Wehner MR, Chren MM, Nameth D, Choudhry A, Gaskins M, Nead KT, Boscardin WJ, Linos E. International prevalence of indoor tanning: a systematic review and meta-analysis. JAMA Dermatol 150(4):390-400, 2014. PMID: 24477278.
48. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med 42(3):610-8, 2014. e-Pub 2014. PMID: 24481828.
49. Downing KP, Nead KT (co-first author), Kojima Y, Assimes T, Maegdefessel L, Quertermous T, Cooke JP, Leeper NJ. The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model. Vasc Med 19(1):3-8, 2014. e-Pub 2013. PMID: 24323119.
50. Priest JR, Nead KT (co-first author), Wehner MR, Cooke JP, Leeper NJ. Self-reported history of childhood smoking is associated with an increased risk for peripheral arterial disease independent of lifetime smoking burden. PLoS One 9(2):e88972, 2014. e-Pub 2014. PMID: 24558458.
51. Nead KT, Cooke JP, Olin JW, Leeper NJ. Alternative ankle-brachial index method identifies additional at-risk individuals. J Am Coll Cardiol 62(6):553-9, 2013. e-Pub 2013. PMID: 23707317.
52. Nead KT, Zhou M, Diaz Caceres R, Olin JW, Cooke JP, Leeper NJ. Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status. Circ Cardiovasc Qual Outcomes 6(3):255-61, 2013. e-Pub 2013. PMID: 23633217.
53. Leeper NJ, Myers J, Zhou M, Nead KT, Syed A, Kojima Y, Caceres RD, Cooke JP. Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. J Vasc Surg 57(3):728-33, 2013. e-Pub 2012. PMID: 23044259.
54. Nead KT, Zhou MJ, Caceres RD, Sharp SJ, Wehner MR, Olin JW, Cooke JP, Leeper NJ. Usefulness of the addition of beta-2-microglobulin, cystatin C and C-reactive protein to an established risk factors model to improve mortality risk prediction in patients undergoing coronary angiography. Am J Cardiol 111(6):851-6, 2013. e-Pub 2013. PMID: 23290308.
55. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes 60(12):3235-45, 2011. PMID: 22110092.
56. Wilson AM, Sadrzadeh-Rafie AH, Myers J, Assimes T, Nead KT, Higgins M, Gabriel A, Olin J, Cooke JP. Low lifetime recreational activity is a risk factor for peripheral arterial disease. J Vasc Surg 54(2):427-32, 432.e1-4, 2011. e-Pub 2011. PMID: 21664093.
57. Sadrzadeh Rafie AH, Stefanick ML, Sims ST, Phan T, Higgins M, Gabriel A, Assimes T, Narasimhan B, Nead KT, Myers J, Olin J, Cooke JP. Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. Vasc Med 15(6):443-50, 2010. PMID: 21183651.
58. Cauchi S, Nead KT (co-first author), Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet 9:45, 2008. e-Pub 2008. PMID: 18498634.
59. Carey RM, McMahon DB, Miller ZA, Kim T, Rajasekaran K, Gopallawa I, Newman JG, Basu D, Nead KT, White EA, Lee RJ. T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. Mol Oncol. e-Pub 2021. PMID: 34717036.
60. Nowakowska MK, Lei X, Thompson MT, Shaitelman SF, Wehner MR, Woodward WA, Giordano SH, Nead, KT. Association of statin use with clinical outcomes in patients with triple-negative breast cancer. Cancer. e-Pub 2021. PMID: 34342892.
61. Arscott WT, Nead KT, Bear A, Venigalla S, Shabason J, Lukens JN, Plastaras JP, Wojcieszynski A, Metz J, O'Hara M, Reiss KA, Teitelbaum U, Loaiza-Bonilla A, Drebin J, Lee MK, Shroff SG, Ben-Josef E. Concurrent Nab-paclitaxel and Radiotherapy: Novel Radiosensitization for Borderline Resectable or Unresectable Pancreatic Cancer. Am J Clin Oncol. e-Pub 2021. PMID: 34310350.
62. Nead KT, Hinkston CL, Linos E, Giordano SH, Wehner MR. American Board of Medical Specialties Board Examination Lactation Accommodation Policies. JAMA Intern Med. e-Pub 2021. PMID: 34180945.

Invited Articles

1. Kim E, Rubinstein SM, Nead KT, Wojcieszynski AP, Gabriel PE, Warner JL. The evolving use of electronic health records (EHR) for research. Semin Radiat Oncol 29(4):354-361, 2019. PMID: 31472738.
2. Nead KT. Androgens and depression: a review and update. Curr Opin Endocrinol Diabetes Obes 26(3):175-179, 2019. PMID: 30958398.
3. Wehner MR, Nead KT. Can Google help us fight cancer?. Lancet Oncol 19:867, 2018.

Editorials

1. Nead KT, Linos E, Vapiwala N.. Increasing diversity in radiation oncology: A call to action. Adv Radiat Oncol 4:226-8, 2019.
2. Nead KT. Androgen deprivation therapy and dementia: New opportunities and challenges in the big-data era. J Clin Oncol 35(30):3380-1, 2017. PMID: 28841386.
3. Wasserfall C, Nead K, Mathews C, Atkinson MA.. The threshold hypothesis: Solving the equation of nurture vs nature in type 1 diabetes. Diabetologia 54:2232-6, 2011.

Book Chapters

1. Nead KT. Low-risk prostate cancer. In: Radiation Oncology - A Question Based Review. 3rd. Wolters Kluwer, 379-388, 2019.
2. Nead KT. Intermediate and high-risk prostate cancer. In: Radiation Oncology - A Question Based Review. 3rd. Wolters Kluwer, 389-398, 2019.
3. Plastaras JP, Nead KT, Meyer J. Primary liver cancer: Hepatocellular carcinoma and intrahepatic cholangiocarcinoma. In: Gastrointestinal Malignancies: A Practical Guide on Treatment Techniques. Springer International Publishing AG, 95-127, 2018.

Letters to the Editor

1. Nead KT, Swisher-McClure S, Shah NH. Androgen Deprivation Therapy and Subsequent Dementia-Reply. JAMA Oncol 3: 1001-1002, 2017.
2. Nead KT, Gaskin G, Chester C, Swisher-McClure S, Dudley JT, Leeper NJ, Shah NH. Reply to R.L. Bowen et al, M. Froehner et al, J.L. Leow et al and C. Brady et al. Journal of Clinical Oncology 34: 2804-5, 2016.