Khandan Keyomarsi, Ph.D.

Peer-Reviewed Articles

1. Kettner NM, Bui TN, Navarro-Yepes J, Ghotbaldini S, Quintela B, Luo CK, Lam N, Rao X, Raghavendra AS, Wang Y, Azizian N, Kris Eckols T, Kasembeli MM, Evans K, Yi M, Wingate H, Wang J, Sahin AA, Meric-Bernstam F, Hunt KK, Damodaran S, Tweardy DJ, Tripathy D, Keyomarsi K. IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer. NPJ Precis Oncol 9(1):260, 2025. e-Pub 2025. PMID: 40715551.
2. Chen MK, Yamaguchi H, Gao Y, Xia W, Chang JT, Hsiao YC, Shegute TW, Lin ZS, Wu CS, Wang YH, Litton JK, Ding Q, Wei Y, Chu YY, Meric-Bernstam F, Piwnica-Worms H, Arun B, Rodon Ahnert J, Liu J, Yao J, Chang WC, Wang HL, Tapia C, Albarracin CT, Keyomarsi K, Wang SC, Wang YN, Hortobagyi GN, Lin C, Yang L, Yu D, Hung MC. FGFR3-induced Y158 PARP1 phosphorylation promotes PARP inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models. J Clin Invest 135(14), 2025. e-Pub 2025. PMID: 40460005.
3. Luo L, Yang P, Mastoraki S, Rao X, Wang Y, Kettner NM, Raghavendra AS, Tripathy D, Damodaran S, Hunt KK, Wang J, Li Z, Keyomarsi K. Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer. Mol Cancer 24(1):48, 2025. e-Pub 2025. PMID: 39955556.
4. Raghavendra AS, Kettner NM, Kwiatkowski D, Damodaran S, Wang Y, Ramirez D, Gombos DS, Hunt KK, Shen Y, Keyomarsi K, Tripathy D. Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2- breast cancer. NPJ Breast Cancer, 2025. e-Pub 2025. PMID: 39865083.
5. Lee, H, Horbath, A, Kondiparthi, L, Meena, JK, Lei, G, Dasgupta, S, Liu, X, Zhuang, L, Koppula, P, Li, M, Mahmud, I, Wei, B, Lorenzi, PL, Keyomarsi, K, Poyurovsky, MV, Olszewski, K, Gan, B. Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nature communications 15(1), 2024. e-Pub 2024. PMID: 38167301.
6. Li M, Lulla AR, Wang Y, Tsavachidis S, Wang F, Karakas C, Nguyen TDT, Bui TN, Pina MA, Chen MK, Mastoraki S, Multani AS, Fowlkes NW, Sahin A, Marshall CG, Hunt KK, Keyomarsi K. Low Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer. Cancer Research 84(22):3864-3880, 2024. e-Pub 2024. PMID: 39186665.
7. Patel, B, Zhou, Y, Babcock, R, Ma, F, Zal, MA, Kumar, D, Medik, YB, Kahn, LS, Pineda, JE, Park, EM, Schneider, S, Tang, X, Raso, G, Jeter, CR, Zal, T, Dwyer, KC, Keyomarsi, K, Giancotti, FG, Colla, S, Watowich, SS. STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response. Leukemia 38(5):1143-1155, 2024. e-Pub 2024. PMID: 38467768.
8. Lulla AR, Akli S, Karakas C, Caruso JA, Warma LD, Fowlkes NW, Rao X, Wang J, Hunt KK, Watowich SS, Keyomarsi K. Neutrophil elastase remodels mammary tumors to facilitate lung metastasis. Mol Cancer Ther 23(4):492-506, 2024. e-Pub 2023. PMID: 37796181.
9. DiPeri TP, Evans KW, Raso MG, Zhao M, Rizvi YQ, Zheng X, Wang B, Kirby BP, Kong K, Kahle M, Yap TA, Dumbrava EE, Ajani JA, Fu S, Keyomarsi K, Meric-Bernstam F. Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers. Clin Cancer Res 29(21):4385-4398, 2023. e-Pub 2023. PMID: 37279095.
10. Navarro-Yepes J, Kettner NM, Rao X, Bishop CS, Bui TN, Wingate HF, Singareeka Raghavendra A, Wang Y, Wang J, Sahin AA, Meric-Bernstam F, Hunt KK, Damodaran S, Tripathy D, Keyomarsi K. Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers. Cancer Res 83(19):3264-3283, 2023. e-Pub 2023. PMID: 37384539.
11. Wingate HF, Keyomarsi K. Distinct Mechanisms of Resistance to CDK4/6 Inhibitors Require Specific Subsequent Treatment Strategies: One Size Does Not Fit All. Cancer Res 83(19):3165-3167, 2023. e-Pub 2023. PMID: 37779425.
12. Haddad TC, Suman VJ, D'Assoro AB, Carter JM, Giridhar KV, McMenomy BP, Santo K, Mayer EL, Karuturi MS, Morikawa A, Marcom PK, Isaacs CJ, Oh SY, Clark AS, Mayer IA, Keyomarsi K, Hobday TJ, Peethambaram PP, O'Sullivan CC, Leon-Ferre RA, Liu MC, Ingle JN, Goetz MP. Evaluation of Alisertib Alone or Combined With Fulvestrant in Patients With Endocrine-Resistant Advanced Breast Cancer: The Phase 2 TBCRC041 Randomized Clinical Trial. JAMA Oncol 9(6):815-824, 2023. e-Pub 2023. PMID: 36892847.
13. Fu S, Yao S, Yuan Y, Previs RA, Elias AD, Carvajal RD, George TJ, Yuan Y, Yu L, Westin SN, Xing Y, Dumbrava EE, Karp DD, Piha-Paul SA, Tsimberidou AM, Ahnert JR, Takebe N, Lu K, Keyomarsi K, Meric-Bernstam F. Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification. J Clin Oncol 41(9):JCO2200830, 2023. e-Pub 2023. PMID: 36469840.
14. Nguyen TDT, Wang Y, Bui TN, Lazcano R, Ingram DR, Yi M, Vakulabharanam V, Luo L, Pina MA, Karakas C, Li M, Kettner NM, Somaiah N, Hougton PJ, Mawlawi O, Lazar AJ, Hunt KK, Keyomarsi K. Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time. Cancer Res 83(6):939-955, 2023. e-Pub 2023. PMID: 36603130.
15. Li M, Tsavachidis S, Wang F, Bui T, Nguyen TDT, Luo L, Multani AS, Bondy ML, Hunt KK, Keyomarsi K. Low-molecular-weight cyclin E deregulates DNA replication and damage repair to promote genomic instability in breast cancer. Oncogene 41(50):5331-5346, 2022. e-Pub 2022. PMID: 36344674.
16. Li H, Wang Y, Lin K, Venkadakrishnan VB, Bakht M, Shi W, Meng C, Zhang J, Tremble K, Liang X, Song JH, Feng X, Van V, Deng P, Burks JK, Aparicio A, Keyomarsi K, Chen J, Lu Y, Beltran H, Zhao D. CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2. Cancer Res 82(17):3088-3101, 2022. e-Pub 2022. PMID: 35771632.
17. Ha MJ, Singareeka Raghavendra A, Kettner NM, Qiao W, Damodaran S, Layman RM, Hunt KK, Shen Y, Tripathy D, Keyomarsi K. Palbociclib plus endocrine therapy significantly enhances overall survival of HR+/HER2- metastatic breast cancer patients compared to endocrine therapy alone in the second-line setting-a large institutional study. Int J Cancer 150(12):2025-2037, 2022. e-Pub 2022. PMID: 35133007.
18. Luo L, Keyomarsi K. PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers. Expert Opin Investig Drugs 31(6):607-631, 2022. e-Pub 2022. PMID: 35435784.
19. Karakas C, Francis AM, Ha MJ, Wingate HF, Meena RA, Yi M, Rasaputra KS, Barrera AMG, Arun B, Do KA, Sahin A, Keyomarsi K, Hunt KK. Cytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer. Ann Surg 274(2):e150-e159, 2021. e-Pub 2021. PMID: 31436549.
20. Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis 10(5):40.doi:10.1038/s41389-021-00324-z, 2021. e-Pub 2021. PMID: 33990543.
21. Chen X, Yang D, Carey JPW, Karakas C, Albarracin C, Sahin AA, Arun BK, Guray Durak M, Li M, Kohansal M, Bui TN, Ha MJ, Hunt KK, Keyomarsi K. Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration. Cancers (Basel) 13(7), 2021. e-Pub 2021. PMID: 33916118.
22. Knudsen ES, Shapiro GI, Keyomarsi K. Selective CDK4/6 Inhibitors: Biologic Outcomes, Determinants of Sensitivity, Mechanisms of Resistance, Combinatorial Approaches, and Pharmacodynamic Biomarkers. Am Soc Clin Oncol Educ Book 40:115-126, 2020. e-Pub 2020. PMID: 32421454.
23. Johnston SJ, Syed BM, Parks RM, Monteiro CJ, Caruso JA, Green AR, Ellis IO, Hunt KK, Karakas C, Keyomarsi K, Cheung KL. Cytoplasmic Cyclin E Is an Independent Marker of Aggressive Tumor Biology and Breast Cancer-Specific Mortality in Women over 70 Years of Age. Cancers (Basel) 12(3), 2020. e-Pub 2020. PMID: 32197318.
24. Mull BB, Livingston JA, Patel N, Bui T, Hunt KK, Keyomarsi K. Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer. Br J Cancer 122(6):812-822, 2020. e-Pub 2020. PMID: 31942030.
25. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer. Clin Cancer Res 25(13):3996-4013, 2019. e-Pub 2019. PMID: 30867218.
26. Chen X, Low KH, Alexander A, Jiang Y, Karakas C, Hess KR, Carey JPW, Bui TN, Vijayaraghavan S, Evans KW, Yi M, Ellis DC, Cheung KL, Ellis IO, Fu S, Meric-Bernstam F, Hunt KK, Keyomarsi K. Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition. Clin Cancer Res 24(24):6594-6610, 2018. e-Pub 2018. PMID: 30181387.
27. Fu S, Wang Y, Keyomarsi K, Meric-Bernstam, Meric-Bernstein F. Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy. Expert Opin Investig Drugs 27(9):1-11, 2018. e-Pub 2018. PMID: 30102076.
28. Carey JPW, Keyomarsi K. Leveraging MYC as a therapeutic treatment option for TNBC. Oncoscience 5(5-6):137-139, 2018. e-Pub 2018. PMID: 30035166.
29. Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics 19(1):150, 2018. e-Pub 2018. PMID: 29458327.
30. Carey JPW, Karakas C, Bui T, Chen X, Vijayaraghavan S, Zhao Y, Wang J, Mikule K, Litton JK, Hunt KK, Keyomarsi K. Synthetic lethality of PARP inhibitors in combination with MYC blockade is independent of BRCA status in triple negative breast cancer. Cancer Res 78(3):742-757, 2018. e-Pub 2018. PMID: 29180466.
31. Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res 28(2):159-170, 2018. e-Pub 2018. PMID: 29273624.
32. Doostan I, Karakas C, Kohansal M, Low KH, Ellis MJ, Olson JA, Suman VJ, Hunt KK, Moulder SL, Keyomarsi K. Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors in Breast Cancer. Clin Cancer Res 23(23):7288-7300, 2017. e-Pub 2017. PMID: 28947566.
33. Francis AM, Alexander A, Liu Y, Vijayaraghavan S, Low KH, Yang D, Bui T, Somaiah N, Ravi V, Keyomarsi K, Hunt KK. CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest. Mol Cancer Ther 16(9):1751-1764, 2017. e-Pub 2017. PMID: 28619757.
34. Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M, Raghavendra AS, Zhao Y, Bashour SI, Ibrahim NK, Karuturi M, Wang J, Winkler JD, Amaravadi RK, Hunt KK, Tripathy D, Keyomarsi K. CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers. Nat Commun 8:15916, 2017. e-Pub 2017. PMID: 28653662.
35. Hunt KK, Karakas C, Ha MJ, Biernacka A, Yi M, Sahin AA, Adjapong O, Hortobagyi GN, Bondy M, Thompson P, Cheung KL, Ellis IO, Bacus S, Symmans WF, Do KA, Keyomarsi K. Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer. Clin Cancer Res 23(12):2991-3002, 2017. e-Pub 2017. PMID: 27881578.
36. Alexander A, Karakas C, Chen X, Carey JP, Yi M, Bondy M, Thompson P, Cheung KL, Ellis IO, Gong Y, Krishnamurthy S, Alvarez RH, Ueno NT, Hunt KK, Keyomarsi K. Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer. Oncotarget 8(9):14897-14911, 2017. e-Pub 2017. PMID: 28107181.
37. Balaji K, Vijayaraghavan S, Diao L, Tong P, Fan Y, Carey JP, Bui TN, Warner S, Heymach JV, Hunt KK, Wang J, Byers LA, Keyomarsi K. AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers. Mol Cancer Res 15(1):45-58, 2017. e-Pub 2017. PMID: 27671334.
38. Bashour SI, Doostan I, Keyomarsi K, Valero V, Ueno NT, Brown PH, Litton JK, Koenig KB, Karuturi M, Abouharb S, Tripathy D, Moulder-Thompson SL, Ibrahim NK. Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. J Cancer 8(11):2004-2009, 2017. e-Pub 2017. PMID: 28819400.
39. Karakas C, Biernacka A, Bui T, Sahin AA, Yi M, Akli S, Schafer J, Alexander A, Adjapong O, Hunt KK, Keyomarsi K. Cytoplasmic Cyclin E and Phospho-Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer. Am J Pathol 186(7):1900-12, 2016. e-Pub 2016. PMID: 27182644.
40. JavanMoghadam S, Weihua Z, Hunt KK, Keyomarsi K. Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion. Cell Cycle 15(12):1579-90, 2016. e-Pub 2016. PMID: 27049344.
41. Nanos-Webb A, Bui T, Karakas C, Zhang D, Carey JP, Mills GB, Hunt KK, Keyomarsi K. PKCiota promotes ovarian tumor progression through deregulation of cyclin E. Oncogene 35(19):2428-40, 2016. e-Pub 2016. PMID: 26279297.
42. Lucenay KS, Doostan I, Karakas C, Bui T, Ding Z, Mills GB, Hunt KK, Keyomarsi K. Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells. Cancer Res 76(8):2406-18, 2016. e-Pub 2016. PMID: 26928812.
43. Jabbour-Leung NA, Chen X, Bui T, Jiang Y, Yang D, Vijayaraghavan S, McArthur MJ, Hunt KK, Keyomarsi K. Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer. Mol Cancer Ther 15(4):593-607, 2016. e-Pub 2016. PMID: 26826118.
44. Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI. PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness. Nat Commun 7:10633, 2016. e-Pub 2016. PMID: 26843124.
45. Mitri Z, Karakas C, Wei C, Briones B, Simmons H, Ibrahim N, Alvarez R, Murray JL, Keyomarsi K, Moulder S. A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer. Invest New Drugs 33(4):890-4, 2015. e-Pub 2015. PMID: 25947565.
46. Caruso JA, Akli S, Pageon L, Hunt KK, Keyomarsi K. The Serine Protease Inhibitor Elafin Maintains Normal Growth Control by Opposing the Mitogenic Effects of Neutrophil Elastase. Oncogene 34(27):3556-67, 2015. e-Pub 2015. PMID: 25195861.
47. Caruso JA, Karakas C, Zhang J, Yi M, Albarracin C, Sahin A, Bondy M, Liu J, Hunt KK, Keyomarsi K. Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Breast Cancer Res 17:87, 2015. e-Pub 2015. PMID: 26108797.
48. Pickering CR, Bast RC, Keyomarsi K. How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?. Cancer 121(6):806-16, 2015. e-Pub 2015. PMID: 25355050.
49. Caruso JA, Campana R, Wei C, Su CH, Hanks AM, Bornmann WG, Keyomarsi K. Indole-3-Carbinol and its N-Alkoxy Derivatives Preferentially Target ERα-Positive Breast Cancer Cells. Cell Cycle 13(16):2587-99, 2014. e-Pub 2014. PMID: 25486199.
50. Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK. 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nat Commun 5:3459, 2014. e-Pub 2014. PMID: 24619206.
51. Caruso JA, Karakas C, Zhang J, Yi M, Albarracin C, Sahin A, Bondy M, Liu J, Hunt KK, Keyomarsi K. Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Breast Cancer Res 16(6):3417, 2014. e-Pub 2014. PMID: 25551582.
52. Murray MM, Bui T, Smith M, Bagheri-Yarmand R, Wingate H, Hunt KK, Keyomarsi K. Staurosporine is chemoprotective by inducing G1 arrest in a Chk1 and pRb dependent manner. Carcinogenesis 34(10):2244-52, 2013. e-Pub 2013. PMID: 23722650.
53. Duong MT, Akli S, Macalou S, Biernacka A, Debeb BG, Yi M, Hunt KK, Keyomarsi K. Hbo1 is a cyclin E / CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res 73(13):1-13, 2013. e-Pub 2013. PMID: 23955388.
54. Dutta P, Bui T, Bauckman KA, Keyomarsi K, Mills GB, Nanjundan M. EVI1 splice variants modulate functional responses in ovarian cancer cells. Mol Oncol 7(3):647-68, 2013. e-Pub 2013. PMID: 23517670.
55. Hunt KK, Wingate H, Yokota T, Liu Y, Mills GB, Zhang F, Fang B, Su CH, Zhang M, Yi M, Keyomarsi K. Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer. Breast Cancer Res 15(1):R3, 2013. e-Pub 2013. PMID: 23320734.
56. Akli S, Zhang XQ, Bondaruk J, Tucker SL, Czerniak PB, Benedict WF, Keyomarsi K. Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer. Cell Cycle 11(7):1468-76, 2012. e-Pub 2012. PMID: 22441703.
57. Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K. Targeting low molecular weight cyclin E (LMW-E) in breast cancer. Breast Cancer Res Treat 132(2):575-88, 2012. e-Pub 2012. PMID: 21695458.
58. Duong MT, Akli S, Wei C, Wingate HF, Liu W, Lu Y, Yi M, Mills GB, Hunt KK, Keyomarsi K. LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients. (Comment - Loeb KR, ChenX, Too much cleavage of cyclin E promotes breast tumorigenesis, PloS Genet.8(3)1002623 Mar 2012). PLoS Genet 8(3):e1002538, 2012. e-Pub 2012. PMID: 22479189.
59. Valero V, Wingate H, Chada S, Liu Y, Palalon F, Mills G, Keyomarsi K, Hunt KK. MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells. Cancer Gene Ther 18(7):510-9, 2011. e-Pub 2011. PMID: 21546925.
60. Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low molecular weight isoform of cyclin E. Cancer Res 71(9):3377-86, 2011. e-Pub 2011. PMID: 21385896.
61. Keyomarsi K, Efuet ET, Bui TN. Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells. Cell Biol Toxicol 27(2):123-31, 2011. e-Pub 2011. PMID: 20853140.
62. Moghadam SJ, Hanks AM, Keyomarsi K. Breaking the cycle: An insight into the role of ERa in eukaryotic cell cycles. J Carcinog 10:25, 2011. e-Pub 2011. PMID: 22190867.
63. Caruso JA, Hunt KK, Keyomarsi K. The Neutrophil Elastase Inhibitor Elafin Triggers Rb-Mediated Growth Arrest and Caspase-Dependent Apoptosis in Breast Cancer. Cancer Res 70(18):7125-36, 2010. e-Pub 2010. PMID: 20823156.
64. Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Liu Y, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene 29(27):3896-907, 2010. e-Pub 2010. PMID: 20453888.
65. Bagheri-Yarmand R, Biernacka A, Hunt KK, Keyomarsi K. Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification. Cancer Res 70(12):5074-84, 2010. e-Pub 2010. PMID: 20530685.
66. Bagheri-Yarmand R, Nanos-Webb A, Biernacka A, Bui T, Keyomarsi K. Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C. Cancer Res 70(12):5085-95, 2010. e-Pub 2010. PMID: 20530684.
67. Sun B, Wingate H, Swisher SG, Keyomarsi K, Hunt KK. Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells. Cell Cycle 9(6):1122-30, 2010. e-Pub 2010. PMID: 20237430.
68. Akli S, Bui T, Wingate H, Biernacka A, Moulder S, Tucker SL, Hunt KK, Keyomarsi K. Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors. Clin Cancer Res 16(4):1179-90, 2010. e-Pub 2010. PMID: 20145171.
69. Mull BB, Cox J, Bui T, Keyomarsi K. Post-translational modification and stability of low molecular weight cyclin E. Oncogene 28(35):3167-76, 2009. e-Pub 2009. PMID: 19561641.
70. Shaye A, Sahin A, Hao Q, Hunt K, Keyomarsi K, Bedrosian I. Cyclin E deregulation is an early event in the development of breast cancer. Breast Cancer Res Treat 115(3):651-9, 2009. e-Pub 2009. PMID: 19107593.
71. Agarwal R, Gonzalez-Angulo AM, Myhre S, Carey M, Lee JS, Overgaard J, Alsner J, Stemke-Hale K, Lluch A, Neve RM, Kuo WL, Sorlie T, Sahin A, Valero V, Keyomarsi K, Gray JW, Borresen-Dale AL, Mills GB, Hennessy BT. Integrative analysis of cyclin protein levels identifies cyclin B1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res 15(11):3654-62, 2009. e-Pub 2009. PMID: 19470724.
72. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early onset breast cancer. PLoS Med 6(5):e1000068, 2009. e-Pub 2009. PMID: 19536326.
73. Delk NA, Hunt KK, Keyomarsi K. Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation. Cancer Res 69(7):2817-25, 2009. e-Pub 2009. PMID: 19318554.
74. Wingate H, Puskas A, Duong M, Bui T, Richardson D, Liu Y, Tucker SL, Van Pelt C, Meijer L, Hunt K, Keyomarsi K. Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression. Cell Cycle 8(7):1062-8, 2009. e-Pub 2009. PMID: 19305161.
75. Keyomarsi K. A novel MCM-2 fragment with potential biological function in senescence. Cell Cycle 7(22):3480, 2008. e-Pub 2008. PMID: 19001846.
76. Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L, Keyomarsi K. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 68(19):7966-74, 2008. e-Pub 2008. PMID: 18829554.
77. Javanmoghadam-Kamrani S, Keyomarsi K. Synchronization of the cell cycle using lovastatin. Cell Cycle 7(15):2434-40, 2008. e-Pub 2008. PMID: 18677105.
78. Yokota T, Bui T, Liu Y, Yi M, Hunt KK, Keyomarsi K. Differential regulation of elafin in normal and tumor-derived mammary epithelial cells is mediated by CCAAT/enhancer binding protein beta. Cancer Res 67(23):11272-83, 2007. e-Pub 2007. PMID: 18056453.
79. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 13(20):6032-9, 2007. e-Pub 2007. PMID: 17947465.
80. Bedrosian I, Lee C, Tucker SL, Palla SL, Lu K, Keyomarsi K. Cyclin E-associated kinase activity predicts response to platinum-based chemotherapy. Clin Cancer Res 13(16):4800-6, 2007. e-Pub 2007. PMID: 17699858.
81. Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67(15):7212-22, 2007. e-Pub 2007. PMID: 17671189.
82. McGahren-Murray M, Terry NH, Keyomarsi K. The Differential Staurosporine-Mediated G1 Arrest in Normal versus Tumor Cells Is Dependent on the Retinoblastoma Protein. Cancer Res 66(19):9744-53, 2006. e-Pub 2006. PMID: 17018634.
83. Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC. Anti-HER2 Antibody Trastuzumab Inhibits CDK2-Mediated NPAT and Histone H4 Expression via the PI3K Pathway. Cell Cycle 5(15):1654-61, 2006. e-Pub 2006. PMID: 16861913.
84. Efuet ET, Keyomarsi K. Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome. Cancer Res 66(2):1040-51, 2006. e-Pub 2006. PMID: 16424040.
85. Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A 102(35):12519-24, 2005. e-Pub 2005. PMID: 16116079.
86. Wingate H, Zhang N, McGarhen MJ, Bedrosian I, Harper JW, Keyomarsi K. The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27. J Biol Chem 280(15):15148-57, 2005. e-Pub 2005. PMID: 15708847.
87. Bales E, Mills L, Milam N, McGahren-Murray M, Bandyopadhyay D, Chen D, Reed JA, Timchenko N, van den Oord JJ, Bar-Eli M, Keyomarsi K, Medrano EE. The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer Res 65(3):692-7, 2005. e-Pub 2005. PMID: 15705861.
88. Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K. Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res 64(9):3198-208, 2004. e-Pub 2004. PMID: 15126360.
89. Bedrosian I, Lu KH, Verschraegen C, Keyomarsi K. Cyclin E deregulation alters the biologic properties of ovarian cancer cells. Oncogene 23(15):2648-57, 2004. e-Pub 2004. PMID: 15007381.
90. Harwell RM, Mull BB, Porter DC, Keyomarsi K. Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. J Biol Chem 279(13):12695-705, 2004. e-Pub 2004. PMID: 14701826.
91. Efuet EE, Keyomarsi K. Novel mechanism of interaction of statins with the proteasome . Proceedings of the American Association for Cancer Research 44:619, 2003. e-Pub 2003.
92. Wingate H, Bedrosian I, Akli S, Keyomarsi K. The low molecular weight (LMW) isoforms of cyclin E deregulate the cell cycle of mammary epithelial cells. Cell Cycle 2(5)(5):461-6, 2003. e-Pub 2003. PMID: 12963845.
93. Keyomarsi K, Tucker SL, Buchholz TA, Callister M, Ding Y, Hortobagyi GN, Bedrosian I, Knickerbocker C, Toyofuku W, Lowe M, Herliczek TW, Bacus SS. Cyclin E and survival in patients with breast cancer. N Engl J Med 347(20):1566-75, 2002. e-Pub 2002. PMID: 12432043.
94. Blagosklonny MV, Campisi J, Keyomarsi K, Medrano EE. No restriction points in life and science. Cell Cycle 1(2):100-2, 2002. e-Pub 2002. PMID: 12429915.
95. Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294(5540):173-7, 2001. e-Pub 2001. PMID: 11533444.
96. Porter DC, Zhang N, Danes C, McGahren MJ, Harwell RM, Faruki S, Keyomarsi K. Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms. Mol Cell Biol 21(18):6254-69, 2001. e-Pub 2001. PMID: 11509668.
97. Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, Keyomarsi K, Yarden Y, Seger R. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 20(2):147-55, 2001. e-Pub 2001. PMID: 11313944.
98. Chen X, Lowe M, Herliczek T, Hall MJ, Danes C, Lawrence DA, Keyomarsi K. Protection of normal proliferating cells against chemotherapy by staurosporine-mediated, selective, and reversible G(1) arrest. J Natl Cancer Inst 92(24):1999-2008, 2000. e-Pub 2000. PMID: 11121462.
99. Porter DC, Keyomarsi K. Novel splice variants of cyclin E with altered substrate specificity. Nucleic Acids Res 28(23):E101, 2000. e-Pub 2000. PMID: 11095697.
100. Chen X, Danes C, Lowe M, Herliczek TW, Keyomarsi K. Activation of the estrogen-signaling pathway by p21(WAF1/CIP1) in estrogen receptor-negative breast cancer cells. J Natl Cancer Inst 92(17):1403-13, 2000. e-Pub 2000. PMID: 10974076.
101. Fasco MJ, Keyomarsi K, Arcaro KF, Gierthy JF. Expression of an estrogen receptor alpha variant protein in cell lines and tumors. Mol Cell Endocrinol 166(2):156-69, 2000. e-Pub 2000. PMID: 11203301.
102. Fasco MJ, Keyomarsi K, Arcaro KF, Gierthy JF. Erratum to "Expression of an estrogen receptor alpha variant protein in cell lines and tumors". Mol Cell Endocrinol 166(2):155-69, 2000. e-Pub 2000. PMID: 10996434.
103. Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res 28(10):2108-13, 2000. e-Pub 2000. PMID: 10773079.
104. Fasco MJ, Keyomarsi K, Arcaro KF, Gierthy JF. Expression of an estrogen receptor alpha variant protein in cell lines and tumors. Mol Cell Endocrinol 162(1-2):167-80, 2000. e-Pub 2000. PMID: 10854710.
105. Harwell RM, Porter DC, Danes C, Keyomarsi K. Processing of cyclin E differs between normal and tumor breast cells. Cancer Res 60(2):481-9, 2000. e-Pub 2000. PMID: 10667604.
106. Chen X, Lowe M, Keyomarsi K. UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent. Oncogene 18(41):5691-5702, 1999. e-Pub 1999. PMID: 10577141.
107. Chen X, Lowe M, Keyomarsi K. UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent. Oncogene 18(40):5691-5702, 1999. e-Pub 1999. PMID: 10523839.
108. Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K. Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci U S A 96(14):7797-802, 1999. e-Pub 1999. PMID: 10393901.
109. Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K. Lovastatin induction of CKIs p21 and p27 and mevalonate reversal of lactacystin are both through modulation of the proteasome, independent of HMG-CoA reductase. Proc. Natl. Acad. Sci. USA 96:7797-7802, 1999. e-Pub 1999.
110. Rao S, Gray-Bablin J, Herliczek TW, Keyomarsi K. The induction of p21 in breast cancer by modulators of cAMP is through a PKA independent mechanism. Exp. Cell Res 252:211-223, 1999. e-Pub 1999.
111. Rao S, Lowe M, Herliczek TW, Keyomarsi K. Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53. Oncogene 17(18):2393-402, 1998. e-Pub 1998. PMID: 9811471.
112. Gray-Bablin J, Rao S, Keyomarsi K. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. Cancer Res 57(4):604-9, 1997. e-Pub 1997. PMID: 9044834.
113. Stover PJ, Chen LH, Suh JR, Stover DM, Keyomarsi K, Shane B. Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene. J Biol Chem 272(3):1842-8, 1997. e-Pub 1997. PMID: 8999870.
114. Gray-Bablin J, Zalvide J, Fox MP, Knickerbocker CJ, DeCaprio JA, Keyomarsi K. Cyclin E, a redundant cyclin in breast cancer. Proc Natl Acad Sci U S A 93(26):15215-20, 1996. e-Pub 1996. PMID: 8986790.
115. Huang Z, Fasco MJ, Figge HL, Keyomarsi K, Kaminsky LS. Expression of cytochromes P450 in human breast tissue and tumors. Drug Metab Dispos 24(8):899-905, 1996. e-Pub 1996. PMID: 8869826.
116. Bacus SS, Yarden Y, Oren M, Chin DM, Lyass L, Zelnick CR, Kazarov A, Toyofuku W, Gray-Bablin J, Beerli RR, Hynes NE, Nikiforov M, Haffner R, Gudkov A, Keyomarsi K. Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells. Oncogene 12(12):2535-47, 1996. e-Pub 1996. PMID: 8700512.
117. Keyomarsi K, Conte D, Toyofuku W, Fox MP. Deregulation of cyclin E in breast cancer. Oncogene 11(5):941-50, 1995. e-Pub 1995. PMID: 7675453.
118. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 6(4):387-400, 1995. e-Pub 1995. PMID: 7626805.
119. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, L-H T, Zhang P, Dobrowlski S, Bai C, Connell-Crowley L, Swindell E, Fox P, Wei N. Analysis of p21-Cdk Interactions In vitro and In vivo: p21 and p27 can collaborate to inihibit Cdks. Mol. Biol. Cell 6:387-400, 1995. e-Pub 1995.
120. Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin. J Med Chem 37(14):2167-74, 1994. e-Pub 1994. PMID: 8035423.
121. Keyomarsi K, O'Leary N, Molnar G, Lees E, Fingert HJ, Pardee AB. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res 54(2):380-5, 1994. e-Pub 1994. PMID: 7903908.
122. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75(4):805-16, 1993. e-Pub 1993. PMID: 8242751.
123. Keyomarsi K, Samet J, Molnar G, Pardee AB. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme. J Biol Chem 268(20):15142-9, 1993. e-Pub 1993. PMID: 8325888.
124. Keyomarsi K, Pardee AB. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci U S A 90(3):1112-6, 1993. e-Pub 1993. PMID: 8430082.
125. Liang P, Averboukh L, Keyomarsi K, Sager R, Pardee AB. Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res 52(24):6966-8, 1992. e-Pub 1992. PMID: 1458489.
126. Motokura T, Keyomarsi K, Kronenberg HM, Arnold A. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. J Biol Chem 267(28):20412-5, 1992. e-Pub 1992. PMID: 1383201.
127. Lee SW, Tomasetto C, Paul D, Keyomarsi K, Sager R. Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol 118(5):1213-21, 1992. e-Pub 1992. PMID: 1324944.
128. Lee SW, Tomasetto C, Swisshelm K, Keyomarsi K, Sager R. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci U S A 89(6):2504-8, 1992. e-Pub 1992. PMID: 1372446.
129. Keyomarsi K, Sandoval L, Band V, Pardee AB. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 51(13):3602-9, 1991. e-Pub 1991. PMID: 1711413.
130. Keyomarsi K, Moran RG. Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate. J Biol Chem 265(31):19163-9, 1990. e-Pub 1990. PMID: 2146271.
131. Geller AI, Keyomarsi K, Bryan J, Pardee AB. An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology. Proc Natl Acad Sci U S A 87(22):8950-4, 1990. e-Pub 1990. PMID: 2174168.
132. Keyomarsi K, Moran RG. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 263(28):14402-9, 1988. e-Pub 1988. PMID: 2971656.
133. Moran RG, Keyomarsi K, Patel R. Biochemical Responses to Treatment with Fluoropyrimidines that Limit Tumor Cell Kill by these Agents. J. Natl. Cancer Inst:71-84, 1988. e-Pub 1988.
134. Moran RG, Keyomarsi K, Patel R. Tumor cell responses to inhibition of thymidylate synthase. Adv Exp Med Biol 244:71-83, 1988. e-Pub 1988. PMID: 2977717.
135. Mahnovski V, Cheng MH, Lipsey AI, Keyomarsi K. Drugs in blood donors. Clin Chem 33(1):189, 1987. e-Pub 1987. PMID: 3802478.
136. Moran RG, Keyomarsi K. Biochemical rationale for the synergism of 5-fluorouracil and folinic acid. NCI Monogr(5):159-63, 1987. e-Pub 1987. PMID: 2963229.
137. Keyomarsi K, Moran RG. Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res 46(10):5229-35, 1986. e-Pub 1986. PMID: 2944577.

Invited Articles

1. Hunt KK, Keyomarsi K. Cyclin E as a prognostic and predictive marker in breast cancer. Semin Cancer Biol 15(4):319-26, 2005. e-Pub 2005. PMID: 16043362.
2. Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 59(4):928-42, 2004. e-Pub 2004. PMID: 15234026.
3. Akli S, Keyomarsi K. Low-molecular-weight cyclin E: the missing link between biology and clinical outcome. Breast Cancer Res 6(5):188-91, 2004. e-Pub 2004. PMID: 15318923.
4. Akli S, Keyomarsi K. Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy. Cancer Biol Ther 2(4 Suppl 1):S38-47, 2003. e-Pub 2003. PMID: 14508079.
5. Bedrosian I, Keyomarsi K. Synopsis of the NEJM article: Cyclin E in Breast Cancer Patients. Breast Diseases Quarterly 14(3):257-8, 2003. e-Pub 2003.
6. Bedrosian I, Keyomarsi K. Cyclin E and survival in patients with breast cancer. The Amer. J Oncology Rev. 2:97-99, 2003. e-Pub 2003.
7. Keyomarsi K. Synchronization of Mammalian Cells by Lovastatin. Methods in Cell Science 18:1-6, 1996. e-Pub 1996.
8. Pardee AB, Keyomarsi K. Modification of cell proliferation with inhibitors. Curr Opin Cell Biol 4(2):186-91, 1992. e-Pub 1992. PMID: 1376129.
9. Fridovich-Keil JL, Hansen LJ, Keyomarsi K, Pardee AB. Progression through the cell cycle: an overview. Am Rev Respir Dis 142(6 Pt 2):S3-6, 1990. e-Pub 1990. PMID: 2252273.

Review Articles

1. Chen MK, Luo L, Massoumi N, Keyomarsi K. Targeting CDK2 and other novel cell cycle targets for breast cancer therapy. Expert Opin Ther Targets 29(7):435-456, 2025. e-Pub 2025. PMID: 40692275.
2. Glaviano A, Singh SK, Lee EHC, Okina E, Lam HY, Carbone D, Reddy EP, O'Connor MJ, Koff A, Singh G, Stebbing J, Sethi G, Crasta KC, Diana P, Keyomarsi K, Yaffe MB, Wander SA, Bardia A, Kumar AP. Cell cycle dysregulation in cancer. Pharmacol Rev 77(2), 2025. e-Pub 2025. PMID: 40148026.
3. Adesoye, T, Tripathy, D, Hunt, KK, Keyomarsi, K. Exploring Novel Frontiers. Cancers 16(3), 2024. e-Pub 2024. PMID: 38339245.
4. Caruso JA, Duong MT, Carey JPW, Hunt KK, Keyomarsi K. Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies. Cancer Res 78(19):5481-5491, 2018. e-Pub 2018. PMID: 30194068.
5. Vijayaraghavan S, Moulder S, Keyomarsi K, Layman RM. Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions. Target Oncol 13(1):21-38, 2018. e-Pub 2018. PMID: 29218622.
6. Lambert L, Keyomarsi K. Cell cycle deregulation in breast cancer: insurmountable chemoresistance or Achilles' heel?. Adv Exp Med Biol 608:52-69, 2007. e-Pub 2007. PMID: 17993232.
7. Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol 209(3):686-94, 2006. e-Pub 2006. PMID: 17001684.

Professional Educational Materials

1. McGhren-Murray M, Keyomarsi K. Staurosporine, an essay in the Encyclopedia of Cancer. Springer, 2009.

Other Articles

1. Glaviano, A, Singh, SK, Clarissa Lee, EH, Okina, E, Lam, HY, Carbone, D, Reddy, EP, O'Connor, M, Koff, A, Singh, G, Stebbing, J, Sethi, G, Crasta, K, Diana, P, Keyomarsi, K, Yaffe, MB, Wander, SA, Bardia, A, Kumar, AP Corrigendum to “Cell cycle dysregulation in cancer” [Pharmacological Reviews 77 (2025) 100030] (Pharmacological Reviews (2025) 77(2), (S0031699724126300), (10.1016/j.pharmr.2024.100030)). Pharmacological Reviews 77(3), 2025.
2. Keyomarsi K, Marino J When breast cancer comes back. Zan Magazine, 2013.
3. Keyomarsi K, Marino J Hormone Therapy. Zan Magazine, 2013.
4. Keyomarsi K, Marino J Chemotherapy of Breast Cancer. Zan Magazine, 2013.
5. Keyomarsi K, Marino J Demystifying Radiation Therapy. Zan Magazine, 2012.
6. Keyomarsi K, Marino J Treatment Options for Breast Cancer. Zan Magazine, 2012.
7. Keyomarsi K, Marino J Lumpectomy vs. Mastectomy. Zan Magazine, 2012.
8. Keyomarsi K Breast Cancer Staging. Zan Magazine, 2012.
9. Keyomarsi K Lump biopsies. Zan Magazine, 2012.
10. Keyomarsi K You feel a lump in your breast now what. Zan Magazine, 2012.

Editorials

1. Buchholz TA Keyomarsi K. Regarding Over-expression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas. Breast Diseases 13, 2002.
2. Buchholz TA Keyomarsi K. Regarding Cyclin E overexpression as an independent risk factor of visceral relapse in breast cancer. Breast Diseases 13, 2002.
3. Buchholz TA Keyomarsi K. Regarding Cyclin E immunoexpression in breast ductal carcinoma: pathological correlations and prognostic implications. Breast Diseases 12:304, 2001.

Book Chapters

1. Alexander A, Keyomarsi K. Exploiting cell cycle pathways in cancer therapy: New (and old) targets and potential strategies. In: Nuclear Signaling Pathways. Springer Science, 337-372, 2013.
2. Fearmonti R, Keyomarsi K, Hunt KK. Biomarkers in neoadjuvant trials. In: Hormone Receptors in Cancer. Springer Science, 125-160, 2009.
3. Lambert L, Lambert D, Keyomarsi K. Understanding the biology of cancer. In: The Biology and Treatment of Cancer. John Wiley & Sons, Inc, 103-122, 2009.
4. Delk N, Keyomarsi K. The Role of cyclin E in Normal and Cancer Cell Cycles. In: Trends in Cell Cycle Research. Research Signpost, 2008.
5. Lambert L, Keyomarsi K. Cell cycle deregulation in breast cancer: Insurmountable chemoresestance or Achilles’ Heel?. In: Breast Cancer Chemosensitivity. Landes Bioscience and Springer Science, 52-69, 2007.
6. Keyomarsi K, Pardee AB. Selective Protection of Normal Proliferating Cells Against the Toxic Effects of Chemotherapeutic Agents. In: Prog Cell Cycle Res, 527-532, 2003.
7. Keyomarsi K, Herliczek TW. The role of cyclin E in cell proliferation, development and cancer. In: Progress in Cell Cycle Research, 171-191, 1997.
8. Pardee AB, Keyomarsi K, Q-P D. Regulation of the Cell Cycle by Kinases and Cyclins. In: Colony Stimulating Factors: Molecular and Cell Biology, 71-95, 1997.
9. Keyomarsi K, O'Leary N, Pardee AB. Cell Division. In: McGraw Hill Encyclopedia of Science and Technology. 8th. McGraw Hill, 1994.
10. Keyomarsi K, Moran RG. Synergistic Interaction Between Folinic Acid and the Flyuoropyrimidines. In: Chemistry and Biology of the Pteridines. Chemistry and Biology of the Pteridines, 691-695, 1986.
11. Moran RG, Keyomarsi K, Colman PD. Preparation of (6-S)5-Formyltetrahydrofolate Labeled at High Specific Activity with 14C and 3H. In: Methods Enzymol, 309-312, Chapter 122, 1986.

Letters to the Editor

1. Hunt KK, Keyomarsi K. Reply to comment by Dr Mesut Tez on Chagpar A, et al. Clinical Outcome of patients with lymph node negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry. Cancer, 2005.
2. Keyomarsi K, Tucker SL, Bedrosian I. Cyclin E is a more powerful predictor of breast cancer outcome than proliferation. Nat Med 9: 152, 2003.
3. Bedrosian I, Tucker SL, Keyomarsi K. Cyclin E in breast Cancer-Reply. N Engl J Med 348: 1064-1064, 2003.
4. Dou QP, Pardee AB, Keyomarsi K. Cyclin E -- a better prognostic marker for breast cancer than cyclin D?. Nat Med 2: 254, 1996.

Patents

1. Method of Detecting Carcinoma. Patent Number: 5543291.
2. Variants and Use Thereof. Patent Number: 5763219.