Meet Kristy Brock, Ph.D.
Kristy K. Brock, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
About Dr. Brock
I have a primary research interest in the interaction of human modeling and radiation therapy. I have investigated the ability of biomechanical models to enhance the veracity of human deformable modeling, and have evaluated the accuracy of deformable alignment methods applied to radiation oncology problems such as contour propagation and dose accumulation. I developed MORFEUS, a comprehensive system for deformable modeling, and lead several investigations in its use on radiation therapy, correlative pathology, and other areas of interest. Over the past few years, I have expanded the biomechanical models to describe anatomical response to radiation, including volume changes and position within the human body.
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Present Title & Affiliation
Primary Appointment
Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
1. Biomechanical Model-Based Deformable Registration: In 2003, I developed a research program focused on the development of a novel deformable modeling technique using biomechanical models and finite element analysis, Morfeus. The technique, which is substantially different than the widely available deformable image registration algorithms that rely on image intensity, incorporates the biomechanical properties of tissues to model the complex interaction of neighboring tissues and tumors. The application has been tested and validated on a number of anatomical sites including head and neck, lung, breast, esophagus, liver, pancreas, stomach, cervix, prostate, and rectum. This has expanded to include modeling of tissue response to radiation, applications in small animals, and generation of 3D or 4D models from limited data.
2. Dose Reconstruction: The development of Morfeus, the biomechanical model-based deformable registration algorithm, has enabled investigations into the reconstruction of a more accurate calculation of the dose delivered to the tumor and surrounding normal tissue over the course of treatment. With the use of accurate deformable registration, the impact of breathing motion, tissue deformation, and tissue volume changes on the delivered dose has been investigated retrospectively to enable intelligent design of prospective clinical trials to adapt to these changes.
3. Correlative Pathology: The use of deformable registration to integrate multi-modality images has raised the question of which imaging modality, or combination correctly identifies the tumor boundary? I have developed a research program in correlative pathology (deformable registration between histology and in vivo images) to investigate this issue. To understand the changes in the material properties during fixation, I have also begun to research the application of magnetic resonance elastography (MRE). The MRE research has also enabled an additional research focus on small animal imaging and intervention to evaluate radiation and drug response, which will improve our understanding of these complex changes for applications in human clinical studies.
Education & Training
Degree-Granting Education
| 2003 | University of Michigan, Ann Arbor, MI, USA, PHD, Nuclear Engineering and Radiological Sciences |
| 2000 | University of Michigan, Ann Arbor, MI, USA, MS, Nuclear Engineering and Radiological Sciences |
| 1999 | University of Michigan, Ann Arbor, MI, USA, BS, Nuclear Engineering and Radiological Sciences |
Board Certifications
| 2008 | The American Board of Radiology |
Experience & Service
Institutional Committee Activities
Member, Radiologic Physics Section Search Committee, 2021 - Present
Honors & Awards
| 2017 | UT STARS Award, The University of Texas System |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Sen A, Fowlkes NW, Kingsley CV, Kulp AM, Huynh T, Willis BJ, Brewer Savannah KJ, Bordes MCA, Hwang KP, McCulloch MM, Stafford RJ, Contreras A, Reece G, Brock KK. Technical note: Histological validation of anatomical imaging for breast modeling using a novel cryo-microtome. Med Phys 48(11):7323-7332, 2021. e-Pub 2021. PMID: 34559413.
- Anderson BM, Lin YM, Lin EY, Cazoulat G, Gupta S, Kyle Jones A, Odisio BC, Brock KK . A novel use of biomechanical model-based deformable image registration (DIR) for assessing colorectal liver metastases ablation outcomes. Med Phys 48(10):6226-6236, 2021. e-Pub 2021. PMID: 34342018.
- Cazoulat G, Anderson BM, McCulloch MM, Rigaud B, Koay EJ, Brock KK . Detection of vessel bifurcations in CT scans for automatic objective assessment of deformable image registration accuracy. Med Phys 48(10):5935-5946, 2021. e-Pub 2021. PMID: 34390007.
- Thrower SL, Al Feghali KA, Luo D, Paddick I, Hou P, Briere T, Li J, McAleer MF, McGovern SL, Woodhouse KD, Yeboa DN, Brock KK, Chung C. The Effect of Slice Thickness on Contours of Brain Metastases for Stereotactic Radiosurgery. Adv Radiat Oncol 6(4):100708, 2021. e-Pub 2021. PMID: 34124413.
- Anderson BM, Wahid KA, Brock KK. Simple Python Module for Conversions between DICOM Images and Radiation Therapy Structures, Masks, and Prediction Arrays. Pract Radiat Oncol 11(3):226-229, 2021. e-Pub 2021. PMID: 33607331.
- Rigaud B, Anderson BM, Yu ZH, Gobeli M, Cazoulat G, Söderberg J, Samuelsson E, Lidberg D, Ward C, Taku N, Cardenas C, Rhee DJ, Venkatesan AM, Peterson CB, Court L, Svensson S, Löfman F, Klopp AH, Brock KK. Automatic Segmentation Using Deep Learning to Enable Online Dose Optimization During Adaptive Radiation Therapy of Cervical Cancer. Int J Radiat Oncol Biol Phys 109(4):1096-1110, 2021. e-Pub 2020. PMID: 33181248.
- Lee M, Simeonov A, Stanescu T, Dawson LA, Brock KK, Velec M. MRI evaluation of normal tissue deformation and breathing motion under an abdominal compression device. J Appl Clin Med Phys 22(2):90-97, 2021. e-Pub 2021. PMID: 33449447.
- Cazoulat G, Balter JM, Matuszak MM, Jolly S, Owen D, Brock KK. Mapping lung ventilation through stress maps derived from biomechanical models of the lung. Med Phys 48(2):715-723, 2021. e-Pub 2020. PMID: 33617034.
- Dominello MM, Sanders T, Anscher M, Bayouth J, Brock KK, Carlson DJ, Hugo G, Joseph S, Knisely J, Mendonca MS, Mian OY, Moros EG, Singh AK, Yu JB. Responses to the 2018 and 2019 "One Big Discovery" Question: ASTRO Membership's Opinions on the Most Important Research Question Facing Radiation Oncology…Where Are We Headed?. Int J Radiat Oncol Biol Phys 109(1):38-40, 2021. e-Pub 2020. PMID: 32798605.
- Anderson BM, Lin EY, Cardenas CE, Gress DA, Erwin WD, Odisio BC, Koay EJ, Brock KK. Automated Contouring of Contrast and Noncontrast Computed Tomography Liver Images With Fully Convolutional Networks. Adv Radiat Oncol 6(1):100464, 2021. e-Pub 2020. PMID: 33490720.
- Yu JB, Brock KK, Campbell AM, Chen AB, Diaz R, Escorcia FE, Gupta G, Hrinivich WT, Joseph S, Korpics M, Onderdonk BE, Pandit-Taskar N, Wood BJ, Woodward WA. Proceedings of the ASTRO-RSNA Oligometastatic Disease Research Workshop. Int J Radiat Oncol Biol Phys 108(3):539-545, 2020. e-Pub 2020. PMID: 32434040.
- Rhee DJ, Jhingran A, Rigaud B, Netherton T, Cardenas CE, Zhang L, Vedam S, Kry S, Brock KK, Shaw W, O'Reilly F, Parkes J, Burger H, Fakie N, Trauernicht C, Simonds H, Court LE. Automatic contouring system for cervical cancer using convolutional neural networks. Med Phys 47(11):5648-5658, 2020. e-Pub 2020. PMID: 32964477.
- Lesage AJ, Rajaram R, Tam AL, Rigaud BS, Brock KK, Rice DC, Cazoulat G. Preliminary evaluation of biomechanical modeling of lung deflation during minimally invasive surgery using pneumothorax computed tomography scans. Phys Med Biol 65(22):22510. e-Pub 2020. PMID: 32906090.
- McCulloch MM, Cazoulat G, Ford AC, Elgohari B, Bahig H, Kim AD, Elhalawani H, He R, Wang J, Ding Y, Mohamed AS, Polan DF, King JB, Peterson CB, Ohrt AN, Fuller CD, Lai SY, Brock KK. Biomechanical modeling of radiation dose-induced volumetric changes of the parotid glands for deformable image registration. Phys Med Biol 65(16):165017, 2020. e-Pub 2020. PMID: 32320955.
- Pursley J, El Naqa I, Sanford NN, Noe B, Wo JY, Eyler CE, Hwang M, Brock KK, Yeap BY, Wolfgang JA, Hong TS, Grassberger C. Dosimetric analysis and normal tissue complication probability modeling of Child-Pugh score and Albumin-Bilirubin grade increase after hepatic irradiation. Int J Radiat Oncol Biol Phys 107(5):986-995, 2020. e-Pub 2020. PMID: 32353390.
- Jacobsen MC, Thrower SL, Ger RB, Leng S, Court LE, Brock KK, Tamm EP, Cressman ENK, Cody DD, Layman RR. Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement. Med Phys 47(8):3752-3771, 2020. e-Pub 2020. PMID: 32453879.
- Parsai S, Qiu RLJ, Qi P, Alfonso JCL, Donaghue J, Murray E, Majkszak D, Dorio N, Fuller CD, Brock K, Koyfman S, Woody N, Joshi N, Scott JG. Technical Note: A step-by-step guide to Temporally Feathered Radiation Therapy planning for head and neck cancer. J Appl Clin Med Phys 21(7):209-215. e-Pub 2020. PMID: 32383296.
- Sen A, Anderson BM, Cazoulat G, McCulloch MM, Elganainy D, McDonald BA, He Y, Mohamed ASR, Elgohari BA, Zaid M, Koay EJ, Brock KK. Accuracy of deformable image registration techniques for alignment of longitudinal cholangiocarcinoma CT images. Med Phys 47(4):1670-1679, 2020. e-Pub 2020. PMID: 31958147.
- Rigaud B, Cazoulat G, Vedam S, Venkatesan AM, Peterson CB, Taku N, Klopp AH, Brock KK . Modeling Complex Deformations of the Sigmoid Colon Between External Beam Radiation Therapy and Brachytherapy Images of Cervical Cancer. Int J Radiat Oncol Biol Phys 106(5):1084-1094, 2020. e-Pub 2020. PMID: 32029345.
- Green CA, Goodsitt MM, Lau JH, Brock KK , Davis CL, Carson PL. Deformable Mapping Method to Relate Lesions in Dedicated Breast CT Images to Those in Automated Breast Ultrasound and Digital Breast Tomosynthesis Images. Ultrasound Med Biol 46(3):750-765, 2020. e-Pub 2019. PMID: 31806500.
- Green CA, Goodsitt MM, Roubidoux MA, Brock KK, Davis CL, Lau JH, Carson PL. Deformable mapping using biomechanical models to relate corresponding lesions in digital breast tomosynthesis and automated breast ultrasound images. Med Image Anal 60:101599, 2020. e-Pub 2019. PMID: 31760192.
- Jin Y, Randall JW, Elhalawani H, Feghali KAA, Elliott AM, Anderson BM, Lacerda L, Tran BL, Mohamed AS, Brock KK , Fuller CD, Chung C. Detection of Glioblastoma Subclinical Recurrence Using Serial Diffusion Tensor Imaging. Cancers (Basel) 12(3), 2020. e-Pub 2020. PMID: 32121471.
- Cazoulat G, Elganainy D, Anderson BM, Zaid M, Park PC, Koay EJ, Brock KK . Vasculature-Driven Biomechanical Deformable Image Registration of Longitudinal Liver Cholangiocarcinoma Computed Tomographic Scans. Adv Radiat Oncol 5(2):269-278, 2020. e-Pub 2019. PMID: 32280827.
- Horie M, Levy L, Houbois C, Salazar P, Saito T, Pakkal M, O'Brien C, Sajja S, Brock K , Yasufuku K, Keshavjee S, Paul N, Martinu T. Lung Density Analysis Using Quantitative Chest CT for Early Prediction of Chronic Lung Allograft Dysfunction. Transplantation 103(12):2645-2653, 2019. e-Pub 2019. PMID: 31343572.
- Joint Head and Neck MRI-Radiotherapy Development Cooperative, Kiser K, Meheissen MAM, Mohamed ASR, Kamal M, Ng SP, Elhalawani H, Jethanandani A, He R, Ding Y, Rostom Y, Hegazy N, Bahig H, Garden A, Lai S, Phan J, Gunn GB, Rosenthal D, Frank S, Brock KK , Wang J, Fuller CD. Prospective quantitative quality assurance and deformation estimation of MRI-CT image registration in simulation of head and neck radiotherapy patients. Clin Transl Radiat Oncol 18:120-127, 2019. e-Pub 2019. PMID: 31341987.
- McCulloch MM, Anderson BM, Cazoulat G, Peterson CB, Mohamed ASR, Volpe S, Elhalawani H, Bahig H, Rigaud B, King JB, Ford AC, Fuller CD, Brock KK . Biomechanical modeling of neck flexion for deformable alignment of the salivary glands in head and neck cancer images. Phys Med Biol 64(17):175018, 2019. e-Pub 2019. PMID: 31269475.
- Brock KK . Adaptive Radiotherapy: Moving into the Future. Semin Radiat Oncol 29(3):181-184, 2019. PMID: 31027635.
- Yang Z, Chang Y, Brock KK , Cazoulat G, Koay EJ, Koong AC, Herman JM, Park PC, Poenisch F, Li Q, Yang K, Wu G, Anderson B, Ohrt AN, Li Y, Zhu XR, Zhang X, Li H. Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies. Radiother Oncol 134:101-109, 2019. e-Pub 2019. PMID: 31005203.
- Rigaud B, Klopp A, Vedam S, Venkatesan A, Taku N, Simon A, Haigron P, de Crevoisier R, Brock KK , Cazoulat G. Deformable image registration for dose mapping between external beam radiotherapy and brachytherapy images of cervical cancer. Phys Med Biol 64(11):115023, 2019. e-Pub 2019. PMID: 30913542.
- Kipritidis J, Tahir BA, Cazoulat G, Hofman MS, Siva S, Callahan J, Hardcastle N, Yamamoto T, Christensen GE, Reinhardt JM, Kadoya N, Patton TJ, Gerard SE, Duarte I, Archibald-Heeren B, Byrne M, Sims R, Ramsay S, Booth JT, Eslick E, Hegi-Johnson F, Woodruff HC, Ireland RH, Wild JM, Cai J, Bayouth JE, Brock K , Keall PJ. The VAMPIRE Challenge: A Multi-Institutional Validation Study of CT Ventilation Imaging. Med Phys 46(3):1198-1217, 2019. e-Pub 2019. PMID: 30575051.
- McCulloch MM, Lee C, Rosen BS, Kamp JD, Lockhart CM, Lee JY, Polan DF, Hawkins PG, Anderson CJR, Heukelom J, Sonke JJ, Fuller CD, Balter JM, Ten Haken RK, Eisbruch A, Brock KK . Predictive Models to Determine Clinically Relevant Deviations in Delivered Dose for Head and Neck Cancer. Pract Radiat Oncol 9(4):e422-e431, 2019. e-Pub 2019. PMID: 30836190.
- Rosen BS, Hawkins PG, Polan DF, Balter JM, Brock KK , Kamp JD, Lockhart CM, Eisbruch A, Mierzwa ML, Ten Haken RK, El Naqa I. Early changes in serial CBCT-measured parotid gland biomarkers predict chronic xerostomia after head and neck radiotherapy. Int J Radiat Oncol Biol Phys 102(4):1319-1329, 2018. e-Pub 2018. PMID: 30003997.
- Bahig H, Yuan Y, Mohamed ASR, Brock KK , Ng SP, Wang J, Ding Y, Hutcheson K, McCulloch M, Balter PA, Lai SY, Al-Mamgani A, Sonke JJ, van der Heide UA, Nutting C, Li XA, Robbins J, Awan M, Karam I, Newbold K, Harrington K, Oelfke U, Bhide S, Philippens MEP, Terhaard CHJ, McPartlin AJ, Blanchard P, Garden AS, Rosenthal DI, Gunn GB, Phan J, Cazoulat G, Aristophanous M, McSpadden KK, Garcia JA, van den Berg CAT, Raaijmakers CPJ, Kerkmeijer L, Doornaert P, Blinde S, Frank SJ, Fuller CD. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial. Clin Transl Radiat Oncol 13:19-23, 2018. e-Pub 2018. PMID: 30386824.
- Brock KK , Yom SS. Seeing What's Before Us: Imaging in the Electronic Age. Int J Radiat Oncol Biol Phys 102(4):675-676, 2018. e-Pub 2018. PMID: 30353874.
- Dominello MM, Keen JC, Beck TF, Bayouth J, Knisely J, Carlson DJ, Mendonca MS, Mian O, Brock KK , Anscher M, Hugo G, Moros EG, Singh AK, Yu JB. Responses to the 2017 '1 Million Gray Question': ASTRO membership's opinions on the most important research question facing radiation oncology. Int J Radiat Oncol Biol Phys 102(2):249-250, 2018. e-Pub 2018. PMID: 30003995.
- Green CA, Goodsitt MM, Brock KK , Davis CL, Larson ED, Lau JH, Carson PL. Deformable mapping technique to correlate lesions in digital breast tomosynthesis and automated breast ultrasound images. Med Phys 45(10):4402-4417, 2018. e-Pub 2018. PMID: 30066340.
- Mohamed ASR, Bahig H, Aristophanous M, Blanchard P, Kamal M, Ding Y, Cardenas CE, Brock KK , Lai SY, Hutcheson KA, Phan J, Wang J, Ibbott G, Gabr RE, Narayana PA, Garden AS, Rosenthal DI, Gunn GB, Fuller CD, MD Anderson MRLinac Development Working Group. Prospective in silico study of the feasibility and dosimetric advantages of MRI-guided dose adaptation for human papillomavirus positive oropharyngeal cancer patients compared with standard IMRT. Clin Transl Radiat Oncol 11:11-18, 2018. e-Pub 2018. PMID: 30014042.
- Horie M, Salazar P, Saito T, Binnie M, Brock KK, Yasufuku K, Azad S, Keshavjee S, Martinu T, Paul N. Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival. Clin Transplant 32(5):e13233, 2018. e-Pub 2018. PMID: 29637624.
- El Naqa I, Brock KK, Yu Y, Langen K, Klein EE. On the Fuzziness of Machine Learning, Neural Networks, and Artificial Intelligence in Radiation Oncology. Int J Radiat Oncol Biol Phys 100(1):1-4, 2018. PMID: 29254765.
- Chapman CH, Polan D, Vineberg K, Jolly S, Maturen KE, Brock KK , Prisciandaro JI. Deformable image registration-based contour propagation yields clinically acceptable plans for MRI-based cervical cancer brachytherapy planning. Brachytherapy 17(2):360-367, 2018. e-Pub 2018. PMID: 29331573.
- McCulloch MM, Muenz DG, Schipper MJ, Velec M, Dawson LA, Brock KK . A simulation study to assess the potential impact of developing normal tissue complication probability models with accumulated dose. Adv Radiat Oncol 3(4):662-672, 2018. e-Pub 2018. PMID: 30370368.
- Polan DF, Feng M, Lawrence TS, Ten Haken RK, Brock KK . Implementing Radiation Dose-Volume Liver Response in Biomechanical Deformable Image Registration. Int J Radiat Oncol Biol Phys 99(4):1004-1012, 2017. e-Pub 2017. PMID: 28864401.
- Chung C, Brock KK. Image-guided radiation therapy: looking beyond what we currently see. Future Oncol 13(26):2317-2319, 2017. e-Pub 2017. PMID: 29121781.
- Brock KK , Mutic S, McNutt TR, Li H, Kessler ML. Use of image registration and fusion algorithms and techniques in radiotherapy: Report of the AAPM Radiation Therapy Committee Task Group No. 132. Med Phys 44(7):e43-e76, 2017. e-Pub 2017. PMID: 28376237.
- Pawlicki T, Ayers RG, Brock KK, Clements JB, Curran BH, Dobbins JT, Samei E, Adams E, Martin MC, Schober L. Proposed changes to the American Association of Physicists in Medicine governance. J Appl Clin Med Phys 18(4):4-6, 2017. PMID: 28681449.
- Velec M, Moseley JL, Svensson S, Hårdemark B, Jaffray DA, Brock KK. Validation of Biomechanical Deformable Image Registration in the Abdomen, Thorax and Pelvis in a Commercial Radiotherapy Treatment Planning System. Med Phys 44(7):3407-3417, 2017. e-Pub 2017. PMID: 28453911.
- Liss AL, Marsh RB, Kapadia NS, McShan DL, Rogers VE, Balter JM, Moran JM, Brock KK, Schipper MJ, Jagsi R, Griffith KA, Flaherty KR, Frey KA, Pierce J. Decreased Lung Perfusion After Breast/Chest Wall Irradiation: Quantitative Results from a Prospective Clinical Trial. Int J Radiat Oncol Biol Phys 97(2):296-302, 2017. e-Pub 2016. PMID: 27986344.
- McGrath DM, Lee J, Foltz WD, Samavati N, van der Kwast T, Jewett MA, Chung P, Ménard C, Brock KK. MR elastography to measure the effects of cancer and pathology fixation on prostate biomechanics, and comparison with T 1, T 2 and ADC. Phys Med Biol 62(3):1126-1148, 2017. PMID: 28092638.
- Ma J, Moerland MA, Venkatesan AM, Bathala TK, Kudchadker RJ, Brock KK, Frank SJ. Pulse sequence considerations for simulation and postimplant dosimetry of prostate brachytherapy. Brachytherapy 16(4):743-753, 2017. e-Pub 2017. PMID: 28063817.
- Samuels SE, Eisbruch A, Vineberg K, Lee J, Lee C, Matuszak MM, Ten Haken RK, Brock KK. Methods for Reducing Normal Tissue Complication Probabilities in Oropharyngeal Cancer: Dose Reduction or Planning Target Volume Elimination. Int J Radiat Oncol Biol Phys 96(3):645-52, 2016. PMID: 27681761.
- Klein EE, Brock KK, Fontenot J, Yu Y. Technical Advances in Oncology Outside of Radiation Medicine. Int J Radiat Oncol Biol Phys 95(5):1323-6, 2016. PMID: 27479719.
- Cazoulat G, Owen D, Matuszak MM, Balter JM, Brock KK. Biomechanical deformable image registration of longitudinal lung CT images using vessel information. Phys Med Biol 61(13):4826-39, 2016. e-Pub 2016. PMID: 27273115.
- Coolens C, Driscoll B, Moseley J, Brock KK, Dawson LA. Feasibility of 4D perfusion CT imaging for the assessment of liver treatment response following SBRT and sorafenib. Adv Radiat Oncol 1(3):194-203, 2016. e-Pub 2016. PMID: 28740888.
- Matuszak MM, Hadley SW, Feng M, Hayman JA, Brock KK, Burger P, Owen D, Suresh K, Schipper M, Lawrence TS, Moran JM. Enhancing safety and quality through preplanning peer review for patients undergoing stereotactic body radiation therapy. Pract Radiat Oncol 6(2):e39-46, 2016. e-Pub 2015. PMID: 26746815.
- McGrath DM, Lee J, Foltz WD, Samavati N, Jewett MA, van der Kwast T, Chung P, Ménard C, Brock KK. Technical Note: Method to correlate whole-specimen histopathology of radical prostatectomy with diagnostic MR imaging. Med Phys 43(3):1065-72, 2016. PMID: 26936694.
- Swaminath A, Knox JJ, Brierley JD, Dinniwell R, Wong R, Kassam Z, Kim J, Coolens C, Brock KK, Dawson LA. Changes in Liver Volume Observed Following Sorafenib and Liver Radiation Therapy. Int J Radiat Oncol Biol Phys 94(4):729-37, 2016. e-Pub 2015. PMID: 26972645.
- Samavati N, Velec M, Brock KK. Effect of deformable registration uncertainty on lung SBRT dose accumulation. Med Phys 43(1):233, 2016. PMID: 26745916.
- Swaminath A, Massey C, Brierley JD, Dinniwell R, Wong R, Kim JJ, Velec M, Brock KK, Dawson LA. Accumulated Delivered Dose Response of Stereotactic Body Radiation Therapy for Liver Metastases. Int J Radiat Oncol Biol Phys 93(3):639-48, 2015. e-Pub 2015. PMID: 26461006.
- Al-Mayah A, Moseley J, Hunter S, Brock KK. Radiation dose response simulation for biomechanical-based deformable image registration of head and neck cancer treatment. Phys Med Biol 60(21):8481-9, 2015. e-Pub 2015. PMID: 26485227.
- Velec M, Juang T, Moseley JL, Oldham M, Brock KK. Utility and validation of biomechanical deformable image registration in low-contrast images. Pract Radiat Oncol 5(4):e401-8, 2015. e-Pub 2015. PMID: 25823381.
- Samavati N, Velec M, Brock K. A hybrid biomechanical intensity based deformable image registration of lung 4DCT. Phys Med Biol 60(8):3359-73, 2015. e-Pub 2015. PMID: 25830808.
- Ménard C, Iupati D, Publicover J, Lee J, Abed J, O'Leary G, Simeonov A, Foltz WD, Milosevic M, Catton C, Morton G, Bristow R, Bayley A, Atenafu EG, Evans AJ, Jaffray DA, Chung P, Brock KK, Haider MA. MR-guided prostate biopsy for planning of focal salvage after radiation therapy. Radiology 274(1):181-91, 2015. e-Pub 2014. PMID: 25203127.
- Fontenot JD, Brock KK, Klein EE. What makes a physics article appealing to a clinical audience?. Int J Radiat Oncol Biol Phys 91(1):20-1, 2015. PMID: 25835620.
- Samavati N, McGrath DM, Jewett MA, van der Kwast T, Ménard C, Brock KK. Effect of material property heterogeneity on biomechanical modeling of prostate under deformation. Phys Med Biol 60(1):195-209, 2015. e-Pub 2014. PMID: 25489840.
- Velec M, Moseley JL, Eccles CL, Craig T, Sharpe MB, Dawson LA, Brock KK. Effect of breathing motion on radiotherapy dose accumulation in the abdomen using deformable registration. Int J Radiat Oncol Biol Phys 80(1):265-72, 2011. e-Pub 2010. PMID: 20732755.
Invited Articles
- Brock KK, Dawson LA. Point: Principles of magnetic resonance imaging integration in computed tomography-based radiotherapy workflow. Seminars in Radiation Oncology 24(3):169-174, 2014.
- Brock KK. Image and image-guided radiation therapy in liver cancer. Seminars in Radiation Oncology 21(4):247-255, 2011.
- Brock KK, Dawson LA. Adaptive management of liver cancer radiotherapy. Seminars in Radiation Oncology 20(2):107-115, 2010.
Grant & Contract Support
| Title: | Optimization and Evaluation of Anatomical Models of Liver Radiation Response |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Anatomical Modeling to Improve the Precision of Image Guided Liver Ablation |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Cancer Center Support Grant (CCSG): Small Animal Imaging Facility |
| Funding Source: | NIH/NCI |
| Role: | Correlative Pathology Service Leader |
| Title: | Radioimmunogenomic Habitat Phenotypes to Predict Efficacy of Neoadjuvant Immunotherapies in Non-Small Cell Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Enhanced Biomechanical Modeling of the Breast for Womens Health |
| Funding Source: | NIH/NIBIB |
| Role: | Principal Investigator |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Core 2: Translational Biospecimens and Imaging Biomarkers |
| Funding Source: | NIH/NCI |
| Role: | Project Co-Lead |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Project 1: Understanding normal tissue toxicity to identify patients most likely to benefit from proton therapy |
| Funding Source: | NIH/NCI |
| Role: | Project Co-Lead |
| Title: | Image Guided Cancer Therapy Training Program |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified September 27, 2024