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Kristy K. Brock, Ph.D.

Department of Imaging Physics, Division of Diagnostic Imaging

About Dr. Brock

I have a primary research interest in the interaction of human modeling and radiation therapy. I have investigated the ability of biomechanical models to enhance the veracity of human deformable modeling, and have evaluated the accuracy of deformable alignment methods applied to radiation oncology problems such as contour propagation and dose accumulation. I developed MORFEUS, a comprehensive system for deformable modeling, and lead several investigations in its use on radiation therapy, correlative pathology, and other areas of interest. Over the past few years, I have expanded the biomechanical models to describe anatomical response to radiation, including volume changes and position within the human body.

Meet Kristy Brock, Ph.D.

Present Title & Affiliation

Primary Appointment

Adjunct Professor, Department of Electrical and Computer Engineering, Division of George R. Brown School of Engineering, Rice University, Houston, TX

Professor (Joint Appointment), Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Department of Electrical and Computer Engineering, Rice University, Houston, TX

Professor, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

1. Biomechanical Model-Based Deformable Registration: In 2003, I developed a research program focused on the development of a novel deformable modeling technique using biomechanical models and finite element analysis, Morfeus. The technique, which is substantially different than the widely available deformable image registration algorithms that rely on image intensity, incorporates the biomechanical properties of tissues to model the complex interaction of neighboring tissues and tumors. The application has been tested and validated on a number of anatomical sites including head and neck, lung, breast, esophagus, liver, pancreas, stomach, cervix, prostate, and rectum. This has expanded to include modeling of tissue response to radiation, applications in small animals, and generation of 3D or 4D models from limited data.2. Dose Reconstruction: The development of Morfeus, the biomechanical model-based deformable registration algorithm, has enabled investigations into the reconstruction of a more accurate calculation of the dose delivered to the tumor and surrounding normal tissue over the course of treatment. With the use of accurate deformable registration, the impact of breathing motion, tissue deformation, and tissue volume changes on the delivered dose has been investigated retrospectively to enable intelligent design of prospective clinical trials to adapt to these changes.

3. Correlative Pathology: The use of deformable registration to integrate multi-modality images has raised the question of which imaging modality, or combination correctly identifies the tumor boundary? I have developed a research program in correlative pathology (deformable registration between histology and in vivo images) to investigate this issue. To understand the changes in the material properties during fixation, I have also begun to research the application of magnetic resonance elastography (MRE). The MRE research has also enabled an additional research focus on small animal imaging and intervention to evaluate radiation and drug response, which will improve our understanding of these complex changes for applications in human clinical studies.

Education & Training

Degree-Granting Education

2003	University of Michigan, Ann Arbor, Michigan, US, Nuclear Engineering and Radiological Sciences, Ph.D
2000	University of Michigan, Ann Arbor, Michigan, US, Nuclear Engineering and Radiological Sciences, M.S
1999	University of Michigan, Ann Arbor, Michigan, US, Nuclear Engineering and Radiological Sciences, BS

Licenses & Certifications

2016	Medical Physicist
2016	Basic Life Support
2008	The American Board of Radiology

Experience & Service

Faculty Academic Appointments

Associate Professor, Department of Nuclear Engineering, University of Michigan, Ann Arbor, MI, 2015 - 2016

Associate Professor, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2013 - 2016

Associate Professor, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 2012 - 2016

Associate Professor, Department of The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario, 2010 - 2012

Associate Professor, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, 2010 - 2012

Associate Professor, Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, 2010 - 2012

Associate Professor, Department of Institute for Medical Sciences, The University of Toronto, Toronto, Ontario, 2010 - 2012

Assistant Professor, Department of Institute for Medical Sciences, University of Toronto, Toronto, Ontario, 2009 - 2010

Assistant Professor, Department of Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, 2009 - 2010

Assistant Professor, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, 2008 - 2010

Scientist, Ontario Cancer Institute, Toronto, Ontario, 2008 - 2012

Assistant Professor, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, 2004 - 2010

Physicist, Department of Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, 2003 - 2012

Administrative Appointments/Responsibilities

IDSO Affiliate, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present

Chair, Ascending Senior Faculty Committee, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present

Member, External Advisory Committee, MicroEnvironment and Tumor Effects of Radiotherapy Center (METEOR U54 ROBIN) Program, Department of School of Medicine, Washington University in St. Louis, St. Louis, MO, 2023 - Present

Member, External Advisory Board, T32 Radiological Sciences Training Grant, Department of Medical Physics, The University of Wisconsin-Madison, Madison, WI, 2022 - Present

Member, Scientific Advisory Board, STARS21 Program, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, 2022 - Present

Member, Scientific Advisory Board, Leeds Cancer Research Centre, Leeds, 2021 - Present

Member, Faculty Diversity Equity and Inclusion Division Council, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - 2023

Member, Faculty Recruiting Panel - Data Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - Present

Member, DI Strategic Planning Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - Present

Member, GSBS Medical Physics Candidacy Exam Committee, Department of Medical Physics Graduate Program, MD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, 2020 - Present

Chair, IP Computational Resource Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2022

Member, Institutional Promotion and Tenure Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2023

Member, GSBS Medical Physics Admissions Committee, Department of Medical Physics Graduate Program, MD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, 2018 - Present

Member, GSBS Medical Physics Steering Committee, Department of Medical Physics Graduate Program, MD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, 2017 - Present

Founding Director, Image Guided Cancer Therapy (IGCT) Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - Present

Member, Graduate Admissions Committee, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2014 - 2015

Head of Dose Reconstruction, Department of Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, 2011 - 2012

Head of Research, Department of Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, 2010 - 2012

Institutional Committee Activities

Member, MDACC GSBS Examining Committee, 2024 - Present

Chair, GSBS Ascending Senior Faculty Committee, 2024 - Present

Member, IP Computational Resources Committee, 2022 - Present

Member, Radiologic Physics Section Search Committee, 2021 - 2022

Honors & Awards

2023	Fellow, American Society for Radiation Oncology (ASTRO)
2023	Distinguished Investigator Award, The Academy for Radiology and Biomedical Imaging
2023	Fellow, American Institute for Medical and Biological Engineering (AIMBE)
2022	Outstanding Researcher, Basic and/or Translational Science, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center
2021	President's Recognition of Faculty Excellence Honoree-Research, The University of Texas MD Anderson Cancer Center
2017	UT STARS Award, The University of Texas System
2015	Fellow, American Association of Physicists in Medicine
2013	Highlight of Preferred Papers, International Conference on Computers in Radiotherapy
2011 - Present	Radiation Physics Research Productivity Award, Radiation Medicine Program, Princess Margaret Hospital
2010 - Present	Radiation Physics Research Productivity Award, Radiation Medicine Program, Princess Margaret Hospital
2010	Postgraduate Medical Education Excellence in Research Supervision, University of Toronto
2009 - 2011	Radiation Physics Research Productivity Award, Radiation Medicine Program, Princess Margaret Hospital
2008	Research Leadership Award, Radiation Medicine Program, Princess Margaret Hospital
2008	Outstanding Research Potential, Department of Radiation Oncology, University of Toronto
2006	Most Influential Research Publication, Radiation Medicine Program, Princess Margaret Hospital
2006	Accuray Award for outstanding research in the field of "High Precision Radiotherapy", European Society for Therapeutic Radiology and Oncology 25 Meeting, Leipzig, Germany
2005	Basic Science Travel Grant, American Society of Therapeutic Radiology and Oncology
2003	Young Investigator Competition Finalist, 45th AAPM Annual Meeting
2002	Rackham Travel Grant and Rackham/International Institute Travel Grant
2001	Rackham Travel Grant
2000	Student Paper Competition Finalist, Chicago 2000 Word Congress on Medical Physics and Biomedical Engineering
1998 - 1999	Most Outstanding Undergraduate Leadership Award, University of Michigan, Ann Arbor, MI
1998	General Electric Faculty for the Future Research Fellowship
1995	Regents Scholarship, University of Michigan, Ann Arbor, MI

Professional Memberships

IEEE Engineering in Medicine Biology Society

2022 - Present

NRG Oncology

2014 - 2019

International Journal of Radiation Oncology, Biology, Physics

2013 - 2019

American Board of Radiology

2013 - 2016

Radiological Society of North America

2013 - 2019

Canadian Association of Radiation Oncology

2004 - 2010

European Society for Therapeutic Radiology and Oncology

2004 - 2010

American Association of Physicists in Medicine

2003 - Present

American Society for Radiation Oncology

2003 - 2024

Selected Presentations & Talks

Local Presentations

2022. The Role of AI in Advancing Image Guided Cancer Therapy. Invited. Houston, Texas, US.
2022. Morfeus Lab Research and Image-Guided Cancer Therapy Research Program, MSTP Program Seminar Series. Invited. Houston, Texas, US.
2022. The Role of AI in Advancing Image Guided Cancer Therapy. Conference. Ken Kennedy Institute's AI in Healthcare Conference. Houston, TX, US.
2020. Harnessing AI and Advanced Image Analysis for COVID Detection and Classification. Invited. Houston, TX, US.
2009. Towards a more accurate understanding of delivered dose and therapeutic response through deformable modeling. Invited. MD Anderson Cancer Center, Ground Rounds. Houston, TX, US.
2009. A Biomechanical Model-Based Approach to Deformable Image Registration and Dose Accumulation. Invited. Houston, Texas, US.

Regional Presentations

2022. Multi-Modality Imaging and Response Assessment: Present and Future. Conference. Veteran Hospital, National Radiation Oncology Program Biennial Conference 2022. San Antonio, TX, US.
2021. Harnessing AI and Biomechanics to Improve Image Guided Cancer Therapy,. Invited. Austin, Texas, US.
2019. Imaging in Oncology: Opportunities for Inter-Disciplinary Translation. Invited. Texas Radiological Society. Austin, TX, US.

National Presentations

2025. Harnessing the Power of Quantitative Imaging to Improve Cancer Outcomes. Invited. Chemical Imaging Gordon Research Conference. Easton, Massachussetts, US.
2025. Robust AI to Guide Therapeutic Interventions. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting, US.
2025. Approaches and Implications Rigid vs Deformable Image Registration in Reirradiation. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting, US.
2025. Update on Current Radiotherapy Technologies and a Look Ahead. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting, US.
2025. Machine Learning Model Evaluation and Interpretation. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting, US.
2024. Deep Learning Image Analysis: From Lab to Clinical Deployment at Scale. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting. Los Angeles, CA, US.
2024. Machine Learning Model Evaluation and Interpretation. Invited. American Association of Physicists in Medicine (AAPM) Annual Meeting. Los Angeles, CA, US.
2024. Concept to Clinical Trials: Translating Technologies from Benchtop to Bedside. Invited. Orlando, FL, US.
2024. Technical Considerations Prior to Planning. Invited. Re-irradiation Collective Guidelines Meeting (ReCoG). Ann Arbor, MI, US.
2024. Trailblazing Together: The Power of Mentorship and Sponsorship. Invited. Winter Institute for Medical Physics. Breckenridge, CO, US.
2024. My Top 5 Irrelevant Words of Brilliant Wisdom and Other Things You Should Ignore. Invited. American Association of Physics in Medicine Southwest Chapter Annual Meeting (SWAAPM), US.
2024. Expanding the Reach of Image Guidance and Image Analysis with RayStation and RayIntelligence. Invited. RaySearch Clinical Advisory Board Meeting. Miami, FL, US.
2024. Deformable Image Registration; Ensuring Clinical Use & Expanding New Frontiers. Invited. Medical Physics Grand Rounds. New York, NY, US.
2024. Image Guided Cancer Therapy Research Program: Breaking Down Barriers to Improve Patient Care. Visiting. Madison, WI, US.
2023. Cancer breakthroughs. Invited. AAPM Annual Meeting 2023, US.
2023. Innovations in breast imaging and histo-pathology correlations using cryo-fluorescence tomography. Invited. WMIC 2023, US.
2023. Harnessing the Power of AI and Biomechanical Modeling for Enhanced Treatment Outcomes. Visiting. Los Angeles, CA, US.
2023. Mentorship in Medical Physics: From Pipeline to Tenure. Conference. Winter Institute for Medical Physics. Breckenridge, CO, US.
2023. Advancing Image-Guided Liver Ablation Through Biomechanical Modeling and AI. Conference. Society of Photo-Optical Instrumentation Engineers. San Diego, CA, US.
2023. Deformable Image Registration: Ensuring Clinical Use and Expanding to New Frontiers. Invited. Medical Physics Grand Rounds. New York, NY, US.
2023. Image Guided Cancer Therapy Research Program: Breaking Down Barriers to Improve Patient Care. Invited. Madison, WI, US.
2022. Radiographic-Pathologic Correlation, The Developing Role of Medical Physics and Imaging in Digital Pathology. Conference. 64th Annual Meeting and Exhibition of the American Association for Physicists in Medicine. Washington, DC, US.
2022. You Can’t Hit What You Aren’t Aiming For: Formulating the Specific Aims Page, Grant Funding Symposium: Pearls and Pitfalls. Conference. 64th Annual Meeting and Exhibition of the American Association for Physicists in Medicine. Washington, DC, US.
2021. Upping Your Game and Crossing Boundaries: Blended Skill Sets in Big Data, AI, Imaging, and Therapy. Conference. American Society for Radiation Oncology Annual Meeting. Chicago, IL, US.
2021. Harnessing Innovation to Drive Patient-Centered Care. Conference. American Society for Radiation Oncology Annual Meeting, Presidential Symposium. Chicago, IL, US.
2021. You Can’t Hit What You’re Not Aiming For: Formulating the Specific Aims Page. Conference. American Society for Radiation Oncology Annual Meeting. Chicago, IL, US.
2021. Debate: AI will Transform Routine Clinical Practice in 5 Years: Real or Overly Optimistic. Invited. Practical Big Data Workshop. Virtual, US.
2021. Harnessing AI to Enable Advanced Image-Guidance in Interventional Procedures. Invited. Conference on Machine intelligence in Medical Imaging. Virtual, US.
2021. Imaging & Image-Guided Radiation Therapy. Invited. Particle Therapy Co-Operative Group North America, Keynote Speaker, US.
2021. The Road to Funding for NIH AIP R01s. Invited. American Association of Physicists in Medicine Annual Meeting. Virtual, US.
2021. Harnessing AI to Enable Advanced Image-Guidance in Interventional Procedures. Invited. American Association of Physicists in Medicine: Society for Imaging Informatics in Medicine Joint Symposium on Machine Intelligence in Medical Imaging. Virtual, US.
2021. How to Write and Review Grants. Invited. Winter Institute for Medical Physics. Virtual, US.
2021. Harnessing the Power of Image Guidance to Improve Delivery, Adaptation, and Patient Outcomes. Conference. Particle Therapy Cooperative Group Annual Meeting, US.
2020. Dose Accumulation and Adaptive RT: Clinical Translation, Usability, and New Horizons. Invited. RaySearch Laboratories, RayStation User Meeting. New York (Virtual), NY, US.
2020. Golden Nuggets for Getting Funded – Technology Focused Grants. Invited. American Society for Radiation Oncology. Miami, US.
2020. Harnessing the Power of Biomechanics and AI for Image Guided Cancer Therapy. Invited. Duke University. Durham, NC, US.
2020. Harnessing the Power of Biomechanical Modeling and Artificial Intelligence in Image Guided Cancer Therapy. Visiting. Durham, NC, US.
2019. Clinical impact of a volumetric image method for confirming tumor coverage with Ablation on patients with malignant Liver Lesions (COVER-ALL). Invited. RayCare Clinical Advisory Meeting. Miami, FL, US.
2019. Computational Analysis to Improve Image Guided HN Treatment and Toxicity Assessment. Invited. University of California San Diego Head and Neck Symposium. San Diego, CA, US.
2019. Cancer Breakthroughs in AAPM. Invited. ASTRO Annual Meeting. Chicago, IL, US.
2019. AI in RO: How We Treat for Cure in Metastatic Disease. Conference. ASTRO Annual Meeting. Chicago, IL, US.
2019. AI in RO: How We Treat for Cure in Metastatic Disease. Invited. ASTRO Annual Meeting. Chicago, IL, US.
2019. Offline Adaptive RT. Invited. AAPM Annual Meeting. San Antonio, TX, US.
2019. Deformable Image Registration in Radiation Therapy. Invited. AAPM Annual Meeting. San Antonio, TX, US.
2019. Deformable Registration Applications in Radiation Oncology. Invited. AAPM Summer School. Vermont, NH, US.
2019. Deep Learning Based Image Registration. Conference. AAPM Summer School. Vermont, NH, US.
2019. Deep Learning Based Image Registration. Invited. AAPM Summer School. Vermont, NH, US.
2019. Clinical Implementation of Full DIR-Based Dose Accumulation: Head and Neck. Invited. Winter Institute for Medical Physics. Breckenriddge, CO, US.
2019. Biomechanical Modeling for Image Guided Cancer Therapy. Visiting. VISE Seminar Series. Nashville, TN, US.
2019. Biomechanical Modeling for Image Guided Cancer Therapy. Invited. Vanderbilt University. Nashville, TN, US.
2018. Artificial Intelligence in Radiation Oncology. Invited. Presidential Plenary Session, US.
2018. Practical Clinical Implementation and Use of Adaptive Radiotherapy. Invited. ASTRO Annual Meeting, US.
2018. Image Guided Cancer Treatment: Integrating Imaging using Biomechanical Models. Visiting. Gainseville, FL, US.
2018. From IRGT to IGCT. Invited. Winter Institute for Medical Physics. Breckenridge, CO, US.
2017. Clinical Commissioning and Integration of Deformable Registration. Visiting. Madison, WI, US.
2017. Advances and Challenges in Contour QA for Adaptive RT. Invited. AAPM Annual Meeting. Denver, CO, US.
2017. The current trajectory of personalized adaptive RT. Invited. AAPM Annual Meeting. Denver, CO, US.
2017. Adaptive Radiotherapy: From the Greens to the Extremes. Winter Institute for Medical Physics. Invited. Adaptive Radiotherapy: From the Greens to the Extremes. Winter Institute for Medical Physics. Breckinridge, CO, US.
2017. SBRT and Personalized Medicine in the Abdomen and Thorax. Invited. Southeast Chapter AAPM Symposium and Scientific Meeting. Charleston, SC, US.
2017. Anatomical Imaging for Personalized Medicine in the Abdomen. Invited. RSNA Annual Meeting. Chicago, IL, US.
2016. Multi-modality Image Registration and Fusion: Evaluating Uncertainty and Building Confidence. Practical Management Strategies and New Innovations in Prostate Radiotherapy Meeting. Invited. Memorial Sloan Kettering Cancer Center. New York City, NY, US.
2016. Personalized Medicine: Abdomen IGRT and Anatomical Adaptation. Invited. Radiological Society of North America. Chicago, IL, US.
2016. Women in Medical Physics. Invited. Winter Institute for Medical Physics (WIMP). Breckenridge, CO, US.
2015. Uncertainties in image registration. Invited. Radiological Society of North America. Chicago, IL, US.
2015. Advantages and potential uncertainties related to the use of DIR for adaptive radiotherapy. Invited. ASTRO Annual Meeting. San Antonio, TX, US.
2015. The role of medical physics innovation in personalized and evidence-based medicine. Invited. University of Chicago. Chicago, IL, US.
2015. Partners in solutions: TG 132 quality assurance for image registration. Invited. AAPM Annual Meeting. Anaheim, CA, US.
2015. Overview of proposed TG-132 recommendations. Invited. AAPM Annual Meeting. Anaheim, CA, US.
2015. Image guidance in the SBRT era: optimizing imaging and managing uncertainties. Invited. AAPM Annual Meeting. Anaheim, CA, US.
2015. QA for in room imaging: the interface of hardware, software, and patients. Invited. SE Chapter AAPM. Raleigh, NC, US.
2015. Clinical implementation and commissioning of deformable registration for treatment planning. Invited. SE Chapter AAPM. Raleigh, NC, US.
2015. Image registration and assessment for adaptive therapy. Invited. AAPM Spring Clinical Meeting. St. Louis, MO, US.
2014. Clinical implementation of DIR: ensuring efficiency, safety, and accuracy. Invited. Great Lakes Chapter AAPM Meeting. Ann Arbor, MI, US.
2014. Correlative pathology: bridging the gap between in vivo imaging and histology. Invited. Brigham and Women's Hospital. Boston, MA, US.
2014. Correlative Pathology: Bridging the Gap Between In Vivo Imaging and Histology. Visiting. Boston, MA, US.
2014. Practical guidance for commissioning and clinical implementation of DIR. Invited. Ohio-Penn Chapter of the AAPM Chapter Meeting, PA, US.
2014. Biomechanics and biomedical imaging: engineering improvements in cancer diagnosis treatment, and assessment. Invited. University of Florida, FL, US.
2014. Biomechanics and Biomedical Imaging: Engineering Improvements in Cancer Diagnosis, Treatment, and Assessment. Visiting. Gainesville, FL, US.
2014. Clinical use of deformable registration tools for dose evaluation, retreatment, and adaptation. Invited. ASTRO Annual Meeting. San Francisco, CA, US.
2014. Image registration II: TG132-quality assurance for image registration. Invited. AAPM Annual Meeting. Austin, TX, US.
2014. Adapt-A-Thon-Texas Hold'em Invitational: adaptive radiotherapy. Invited. AAPM Annual Meeting. Austin, TX, US.
2014. The promise and potential pitfalls of deformable image registration in clinical practice: introduction and overview of DIR methods and challenges. Invited. AAPM Annual Meeting. Austin, TX, US.
2014. Image registration and clinical adaptation in the abdomen. Invited. RAMPS Spring Symposium: Adaptive Therapy. New York, NY, US.
2013. Practical use of image registration and data fusion for planning, delivery, and adaptation of radiation therapy. Invited. ASTRO Annual Meeting. Atlanta, GA, US.
2013. Advanced applications in deformable registration. Invited. AAPM Annual Meeting. Indianapolis, IN, US.
2013. TG 132: image registration and fusion. Invited. AAPM Annual Meeting. Indianapolis, IN, US.
2013. How has imaging changed what we do: adaptive radiotherapy - tools needed. Invited. ASTRO Cancer Imaging and Radiation Therapy Symposium. Orlando, FL, US.
2013. Uncertainties in image registration. Invited. RSNA Annual Meeting. Chicago, IL, US.
2013. Adaptive RT for personalized medicine: from research to clinical practice. Invited. Delaware Valley Chapter of the AAPM Symposium. Philadelphia, PA, US.
2013. Deformable Dose Reconstruction: Improving Patient Care and Understanding Radiation Response. Visiting. Chicago, IL, US.
2013. Deformable dose reconstruction: improving patient care understanding radiation response. Invited. University of Chicago. Chicago, IL, US.
2012. Deformable Dose Reconstruction: Improving Patient Care and Understanding Radiation Response. Visiting. St. Louis, MO, US.
2012. Ensuring safe clinical implementation of image registration and data fusion: acceptance testing and quality assurance. Invited. ImSim QA Lunch and Learn, American Association of Physicists in Medicine Annual Meeting. Charlotte, NC, US.
2012. Practical use of image registration and data fusion for planning, delivery, and adaptation of radiation therapy. Invited. ASTRO Annual Meeting. Boston, MA, US.
2012. Personalized medicine: adapting to the individual. Anatomical adaptation - it all begins here. Invited. American Association of Physicists in Medicine Annual Meeting. Charlotte, NC, US.
2012. Deformable dose reconstruction: improving patient care and understanding radiation response. Invited. Washington University. St. Louis, MO, US.
2012. Uncertainties in deformable image registration. Invited. RSNA Annual Meeting. Chicago, IL, US.
2011. Deciding what to target with IG-IMRT: The role of correlative pathology. Invited. Brigham and Women's Hospital. Boston, MA, US.
2011. Improving the correlation between delivered dose and therapeutic response: dose recognition in liver SBRT. Invited. Memorial Sloan Kettering Cancer Center. New York, NY, US.
2011. The use of biomechanics in deformable image registration. Invited. New England AAPM Meeting. Boston, MA, US.
2011. Motion management SBRT, IGRT, IMRT. Invited. ASTRO State of the Art Techniques: IMRT, IGRT, SBRT. Las Vegas, NV, US.
2011. Biomechanical modeling of human physiological motion. Invited. Altair HyperWorks Annual User Group Conference. Orlando, FL, US.
2011. Deformable registration and dose accumulation: techniques, QA, and implementations. Invited. ASTRO Annual Meeting. Miami, FL, US.
2011. Uncertainties in deformable registration. Invited. American Association of Physicists in Medicine Annual Summer School, Simon Fraiser University, US.
2011. MR-guided prostate biopsy and brachytherapy. Invited. 4th NCIGT and NIH Image Guided Therapy Workshop. Arlington, VA, US.
2011. Imaging challenges in radiation oncology: what if the target is changing? Deformable registration. Invited. RSNA Annual Meeting. Chicago, IL, US.
2011. Deformable dose reconstruction: from research to patient QA and back. Invited. University of Michigan Medical Center. Ann Arbor, MI, US.
2011. Improving the correlation between delivered dose and therapeutic response: deformable dose accumulation in liver SBRT. Invited. Brigham and Women's Hospital. Boston, MA, US.
2011. Deformable image registration in image guided therapy. Invited. UCSF Radiation Oncology Update: Perspective on New Technologies, Clinical Findings, and Safety. San Francisco, CA, US.
2010. Implementation of adaptive radiation therapy. Invited. ASTRO Annual Meeting. San Diego, CA, US.
2010. Optimizing MR imaging for treatment planning. Invited. AAPM Annual Meeting. Philadelphia, PA, US.
2010. Improving contouring and segmentation. Invited. ASTRO Annual Meeting. San Diego, CA, US.
2010. Imaging challenges for radiation oncology: imaging for adaptive planning - what if the target changes? Deformable registration. Invited. RSNA Annual Meeting. Chicago, IL, US.
2009. Deformable registration for adaptive head and neck radiotherapy. Invited. AAPM Annual Meeting. Anaheim, CA, US.
2009. Image registration in IGRT. Invited. American Society for Radiation Oncology IGRT Symposium. Miami, FL, US.
2009. Respiratory management. Invited. The Princess Margaret Hospital Experience, Washington University, St. Louis, Respiration Motion Management Workshop. St. Louis, MO, US.
2009. Auto-segmentation using biomechanical models. Invited. AAPM Annual Meeting. Anaheim, CA, US.
2009. Imaging challenges for radiation oncology: imaging for adaptive planning - what if the target changes? Deformable registration. Invited. RSNA Annual Meeting. Chicago, IL, US.
2009. Image registration of image guided and adaptive radiotherapy. Invited. CARO Annual Meeting.
2008. Image processing and analysis for personalized and evidence-based medicine. Invited. American Association of Physicists in Medicine Annual AAPM Meeting. Houston, TX, US.
2008. Imaging for Treatment Planning. Invited. American Association of Physicists in Medicine AAPM Annual Meeting. Houston, TX, US.
2008. Improved Precision in Liver SBRT through Deformable Registration. Invited. Scientific Conference on Stereotactic Body Radiation Therapy: Innovations and Directions for Clinical Applications. Rochester, NY, US.
2007. Imaging for treatment planning: abdomen. Invited. Radiologic Society of North America RSNA Annual Meeting. Chicago, IL, US.
2007. Imaging for treatment planning. Invited. American Association of Physicists in Medicine AAPM Annual Meeting. Minneapolis, MN, US.
2007. The great debate: The future of IGRT is... Invited. American Association of Physicists in Medicine AAPM Annual Meeting. Minneapolis, MN, US.
2006. Imaging for treatment planning: abdomen. Invited. Radiologic Society of North America RSNA Annual Meeting. Chicago, IL, US.
2006. Image registration for IGRT. Invited. ASTRO 2006 IGRT Symposium. Las Vegas, NV, US.
2005. The role of deformable image registration. Invited. IGTX @ Sea Workshop, AK, US.
2004. Inclusion of organ motion and deformation in dose calculations. Invited. American Association of Physicists in Medicine, 46th Annual AAPM Meeting. Pittsburgh, PA, US.
2003. Effect of Liver Deformation on Dose Calculations. Invited. Chicago, IL, US.
2002. Inclusion of Organ Deformation in Dose Calculations for Radiotherapy. Invited. Ann Arbor, MI, US.
2002. Inclusion of Liver Deformation in Dose Calculations. Invited. Cambridge, MA, US.

International Presentations

2024. Image-Guided Adaptive Radiotherapy to personalize risk assessment and guide treatment. Invited. CaPTion in conjuction MICCAI. Marrakesh, MA.
2024. 25 Years of Adaptive Radiotherapy: Where Can Computers Take Adaptative Radiotherapy Now?. Invited. Keynote Lecture, International Conference on the use of Computers in Radiation Therapy. Lyon, FR.
2024. Data Science to Improve Accuracy and Outcomes in Interventional Radiology. Invited. IEEE and Bio-X International Summer Leadership Academy. Crete, GR.
2024. Data Science to Improve Access, Increase Local Control, and Reduce Toxicities for Cancer Treatment with Radiation Therapy. Invited. IEEE and Bio-X International Summer Leadership Academy. Crete, GR.
2024. Breaking Barriers: Women Leading the Way in Medical Physics. Invited. Glasgow, GB.
2024. Accumulation for Daily Adaptation. Invited. Glasgow, GB.
2022. Data Science and Engineering for Image Guided Interventions. Conference. Workshop Keynote, 25th International Conference on Medical Image Computing and Computer Assisted Intervention, SG.
2022. AI and Biomechanical Modeling for Advances in Image-Guided Focal Liver Ablation. Conference. European Society of Radiology, AT.
2022. Advances in Biomechanics and AI for Precision Radiotherapy. Invited. Toronto, CA.
2022. Operational Ontology for Radiation Oncology. Conference. IEEE and Bio-X International Summer School, GR.
2022. Data Science and Engineering for Image Guided Interventions. Conference. IEEE and Bio-X International Summer School, GR.
2022. Data Science and Engineering for Image Guided Radiation Therapy – Precision Treatment, Adaptation, and Improved Outcomes Prediction. Conference. IEEE and Bio-X International Summer School, GR.
2022. AI in Medical Imaging. Conference. IEEE and Bio-X International Summer School, GR.
2022. Deformable Registration for Dose Accumulation: Current Status and Future Challenges. Conference. European Society for Therapeutic Radiation Oncology, DK.
2021. Dose Accumulation and Adaptive RT: Clinical Translation, Usability, and New Horizons,. Invited, US.
2021. Future Challenges in Deformable Image Registration. Invited. 2021 Physics Workshop -Commissioning and QA for Deformable Image Registration in RT for the European Society of Therapeutic Radiation Oncology. Virtual, US.
2021. Challenges and Opportunities in the Clinical Translation of AI for Image Guided Cancer Therapy. Invited. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2021). Virtual, US.
2020. Innovation on image-guided cancer therapies: The Role of High-fidelity Imaging and AI. Invited. SOBRICE. San Palo, BR.
2019. Harnessing the Power of Biomechanics and AI for Image Guided Cancer Therapy. Invited. Netherlands Cancer Institute. Amsterdam, NL.
2019. Harnessing the Power of Deformable Registration and Dose Accumulation in Radiation Therapy. Invited. International Conference on Computers in Radiotherapy, CA.
2019. Commissioning and Clinical Implementation of Dose Accumulation and Adaptive Radiology. Invited. ESTRO. Milan, IT.
2018. The Current Trajectory of Adaptive Radiotherapy. Invited. XXIII Brazilian Congress of Medical Physics, BR.
2018. Deformable Image Registration and Fusion: Clinical Aspects and QA. Invited. XXIII Brazilian Congress of Medical Physics, BR.
2018. Image Guidance in the SBRT Era: Optimizing Imaging and Managing Uncertainties. Invited. XXIII Brazilian Congress of Medical Physics, BR.
2018. Patient Modeling. Invited. Sonke Symposium. Amsterdam, NL.
2018. Image Registration and Fusion Algorithms and Techniques. Invited. IUPESM World Congress on Medical Physics and Biomedical Engineering. Prague, CZ.
2018. Advancing the Integration of Imaging in Surgery, Interventional Radiology, and Radiation Oncology. Visiting. Sydney Imaging Launch and Symposium. Sydney, AU.
2018. Automatic segmentation and deformable registration? Setting the stage. Invited. ESTRO 37. Barcelona, US.
2017. Development and Clinical Implementation of Image Registration and Dose Accumulation. Invited. ESTRO. Vienna, AT.
2017. Liver IG/SBRT Education Course. Radiation Medicine Program at Princess Margaret. Invited. Liver IG/SBRT Education Course. Radiation Medicine Program at Princess Margaret. Toronto.
2016. Implementing Dose Accumulation in Standard Practice: Is it clinically feasible and evidence driven?. Conference. Engineering and Physics Science in Medicine. Sydney, AU.
2016. Innovations in Anatomical Modeling to Advance Image Guided Therapy. Invited. Engineering and Physics Science in Medicine. Sydney, AU.
2016. DIR: What it is, What it isn't, Engineering and Physics Science in Medicine. Invited. Summer School. Sydney, AU.
2016. Implementing Dose Accumulation in Standard Practice: Is it clinically feasible and evidence driven?,. Invited. Sydney, AU.
2015. Gender, Science, and technology: the role of women in medical physics. Invited. World Congress on Medical Physics and Biomedical Engineering, CA.
2013. Motion Management: SBRT/IGRT/IMRT. Invited. RANCER Annual Meeting, NZ.
2013. Adaptive RT: imaging, dose accumulation, and ensuring it is correct. Invited. RANZCR Annual Meeting, NZ.
2013. Adaptive RT: imagerie, accumulation of doses, et de s'assurer qu'elle est correcte. Invited. Quebec Provincial Association of Clinical Medical Physicists Annual Workshop, CA.
2012. Image validation through correlative pathology. Invited. World Congress on Biomedical Engineering and Medical Physics, CN.
2012. MR segmentation. Invited. IGRT, Controllo del Movimiento Respiratorio E Imaging Avanzato in Radioterapia, IT.
2012. Deformable registration in IGRT: techniques, QA and implementation. Invited. IGRT, Controllo del Movimiento Respiratorio E Imaging Avanzato in Radioterapia, IT.
2012. Auto-segmentation and deformable registration for lung and liver cancer radiotherapy. Invited. World Congress on Biomedical Engineering and Medical Physics, CN.
2012. Can deformable registration approaches be reliable?. Invited. ESTRO Annual Meeting, ES.
2011. Adaptive radiotherapy: imaging, dose accumulation, and ensuring it is correct. Invited. BIRC Seminar Series. London, CA.
2011. Morfeus: the details and clinical applications. Invited. RaySearch Laboratories, SE.
2011. Integrating deformable registration into clinical practice: perks and pitfalls. Invited. RaySearch Laboratories, RayStation User Meeting, CA.
2011. Adaptive Radiotherapy: Imaging, Dose Accumulation, and Ensuring it is Correct,. Visiting. London, CA.
2011. Image registration and dose warping for inter-fraction deformation. Invited. GEC-ESTRO Annual Meeting, GB.
2010. Deformable registration, dose accumulation and verification. Invited. Pre-ESTRO Workshop, Adaptive Radiotherapy, ES.
2010. Deformable registration in prostate radiotherapy. Invited. ESTRO 29 Annual Meeting, ES.
2009. Validation methods for auto-segmentation and deformable registration. Invited. 10th Biennial ESTRO Conference on Physics and Radiation Technology for Clinical Radiotherapy, NL.
2009. Integration of MRI in radiation therapy through deformable modeling. Invited. ESTRO Pre-Conference Teaching Course, NL.
2009. Multi-organ models for personalized and evidence-based medicine. Invited. Varian Workshop 3D Deformable Image Registration in Radiation Therapy - A Challenge, CH.
2009. Deformable Registration using a Biomechanical Model-Based Technique. Visiting. Maastricht, NL.
2009. Improving tumor definition and targeting through deformable models. Invited. Target Insight III, CA.
2009. A biomechanical model-based approach to deformable image registration. Invited. Real-Time Motion Adaptive Radiation Therapy Workshop, DE.
2008. Image Registration of Image Guided and Adaptive Radiotherapy. Invited. CARO-COMP, CA.
2008. Challenges in online image guided radiotherapy management for liver tumors. Invited. European Society for Therapeutic Radiation Oncology, SE.
2008. Deformable modeling techniques to facilitate classification, targeting, and response assessment. Invited. Field's Institute, CA.
2008. Integration through registration: Deformable registration for IGRT. Invited. IGRT 2008 Symposium, DK.
2008. A biomechanical model-based approach to deformable registration: technical developments and applications. Invited. MICe, CA.
2007. Deformable modeling for image guided planning, delivery, and assessment. Invited. McGill Monte Carlo Workshop, CA.
2007. Image registration of image guided and adaptive radiotherapy. Invited. CARO-COMP, CA.
2006. Realization of Volumetric Image Guidance for Radiation Therapy. Invited. Copenhagen, DK.
2006. Image Processing and Analysis in Radiotherapy Planning: Image Registration. Invited. Copenhagen, DK.
2006. From Planning through Follow-up: Improved targeting and assessment through deformable modeling. Invited. Montreal, CA.
2006. Image processing and analysis in radiotherapy planning: image registration. Invited. MICCAI The Medical Image Computing and Computer Assisted Intervention Society, DK.
2006. Realization of volumetric image guidance for radiation therapy. Invited. MICCAI The Medical Image Computing and Computer Assisted Intervention Society, DK.
2006. Modeling organ deformations (with finite-element methods). Workshop on IMRT radiation therapy treatment planning: target uncertainties, computational challenges and beyond. Invited. The Field's Institute for Research in Mathematical Sciences, CA.
2005. MR-based simulation in radiotherapy: improving tumor definition, characterizing motion, and monitoring response. Invited. ESTRO Workshop on Image-Guided Radiotherapy, PT.

Formal Peers

2023. Deformable Image Registration: Ensuring Clinical Use and Expanding to New Frontiers. Invited. Virtual, US.
2023. Image Guided Cancer Therapy Research Program: Breaking Down Barriers to Improve Patient Care. Invited. Madison, WI, US.
2022. The Role of AI in Advancing Image Guided Cancer Therapy. Visiting. Houston, TX, US.
2022. Morfeus Lab Research and Image-Guided Cancer Therapy Research Program. Invited. Houston, TX, US.
2022. Advances in Biomechanics and AI for Precision Radiotherapy. Invited. Virtual, Toronto, CA.
2021. Dose Accumulation and Adaptive RT: Clinical Translation, Usability, and New Horizons. Invited. Virtual, US.
2020. Harnessing AI and Advanced Image Analysis for COVID Detection and Classification. Visiting. Virtual, TX, US.
2018. Advancing the Integration of Imaging in Surgery, Interventional Radiology, and Radiation Oncology. Visiting. Sydney, US.
2018. Image Guided Cancer Treatment: Integrating Imaging using Biomechanical Models. Visiting. Gainesville, FL, US.
2017. Clinical Commissioning and Integration of Deformable Registration. Visiting. Madison, WI, US.
2014. Correlative Pathology: Bridging the Gap Between In Vivo Imaging and Histology. Visiting. Boston, MA, US.
2014. Biomechanics and Biomedical Imaging: Engineering Improvements in Cancer Diagnosis, Treatment, and Assessment. Visiting, FL, US.
2013. Deformable Dose Reconstruction: Improving Patient Care and Understanding Radiation Response. Visiting. Chicago, IL, US.
2012. Deformable Dose Reconstruction: Improving Patient Care and Understanding Radiation Response. Visiting. St. Louis, MO, US.
2011. Adaptive Radiotherapy: Imaging, Dose Accumulation, and Ensuring it is Correct. Visiting. London, Ontario, CA.
2009. A Biomechanical Model-Based Approach to Deformable Image Registration and Dose Accumulation. Visiting. Houston, TX, US.
2009. Deformable Registration using a Biomechanical Model-Based Technique. Visiting. Maastricht, NL.
2006. Image Processing and Analysis in Radiotherapy Planning: Image Registration. Visiting, Copenhagen, DK.
2006. Realization of Volumetric Image Guidance for Radiation Therapy. Visiting, Copenhagen, DK.
2006. From Planning through Follow-up: Improved targeting and assessment through deformable modeling. Invited. Montreal, CA.
2003. Effect of Liver Deformation on Dose Calculations. Invited. Chicago, IL, US.
2002. Inclusion of Organ Deformation in Dose Calculations for Radiotherapy. Invited. Ann Arbor, MI, US.
2002. Inclusion of Liver Deformation in Dose Calculations. Invited. Cambridge, MA, US.

Less

Grant & Contract Support

Date:	2025 - 2029
Title:	IG-RABIT: Image-Guided, Robot-Assisted, Biomechanically-Informed Osteotomy and Surgical Implants for Orthopaedic Oncology
Funding Source:	UTMDACC Accelerator Program
Role:	Key Personnel

Date:	2024 - 2029
Title:	OPC SURVIVOR: Optimizing OroPharyngeal Cancer SURVIVORship (CORE B)
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1P01CA285249-01A1

Date:	2024 - 2025
Title:	Strategic Research Initiative Development - Tumor Measurement Initiative
Funding Source:	UTMDACC
Role:	Project Leader

Date:	2024 - 2029
Title:	Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1R01CA279467-01A1

Date:	2024 - 2029
Title:	The Academy at MD Anderson UTHealth Houston Graduate School – Maximizing Opportunities for Training, Development, and Community
Funding Source:	NIH/NIGMS
Role:	Mentor
ID:	T32GM152796

Date:	2023 - 2028
Title:	Risk Stratification for and Early Detection of Liver Cancer
Funding Source:	NIH/NCI
Role:	Other Significant Contributor
ID:	2U01CA230997-07

Date:	2023 - 2026
Title:	STRATEGIC ALLIANCE - Artidis Alliance- Umbrella Protocol: Pancreatic, hepatobiliary, soft tissue sarcoma, chondrosarcoma, chordoma, and lung cancers
Funding Source:	Strategic Alliance with Artidis
Role:	Co-I

Date:	2023 - 2028
Title:	Dissemination and Implementation of DIGEST as an Evidence-based Measurement Tool for Dysphagia In Cancer
Funding Source:	NIH/NCI
Role:	Co-I
ID:	5R01CA271223-03

Date:	2022 - 2027
Title:	PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium Coordination, Data Management and Education)
Funding Source:	NIH/NCI
Role:	Internal Advisory Board Member
ID:	5U24CA274274-03

Date:	2022 - 2026
Title:	Enhanced Biomechanical Modeling of the Breast for Womens Health
Funding Source:	NIH/NIBIB
Role:	PI
ID:	5R01EB032533-04

Date:	2022 - 2027
Title:	Image Guided Cancer Therapy Training Program
Funding Source:	NIH/NCI
Role:	PI
ID:	5T32CA261856-03

Date:	2021 - 2026
Title:	Integrating Patient-specific Clinical and Biological Factors Towards Individualizing Utilization of Proton and Photon Radiation Therapy: Project 1: Understanding Normal Tissue Toxicity to Identify Patients Most likely to Benefit From Proton Therapy
Funding Source:	NIH/NCI
Role:	Project Co-Lead
ID:	5P01CA261669-04

Date:	2021 - 2026
Title:	Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Core 2: Translational Biospecimens and Imaging Biomarkers
Funding Source:	NIH/NCI
Role:	Co-Core Lead
ID:	5P01CA261669-04

Date:	2021 - 2026
Title:	Radioimmunogenomic Habitat Phenotypes to Predict Efficacy of Neoadjuvant Immunotherapies in Non-Small Cell Lung Cancer
Funding Source:	NIH/NCI
Role:	Co-I
ID:	5R01CA262425-04

Date:	2019 - 2026
Title:	Cancer Center Support Grant (CCSG): Small Animal Imaging Facility
Funding Source:	NIH/NCI
Role:	Correlative Pathology Service Leader
ID:	4P30CA016672-48

Date:	2019 - 2026
Title:	Cancer Center Support Grant - Image-Driven Biology-Informed Therapy (IDBT)
Funding Source:	NIH/NCI
Role:	Program Leader
ID:	4P30CA016672-48

Selected Publications

Peer-Reviewed Articles

Sacks, MS, Thomas, B, Goodbrake, C, Webb, A, Kingsley, CV, Stafford, J, Reece, GP, Brock, K. A novel diffusion tensor based three-dimensional constitutive model for human breast tissue. Journal of the Mechanical Behavior of Biomedical Materials 168, 2025. e-Pub 2025. PMID: 40262429.
Humbert-Vidan, L, Kamel, S, Wentzel, A, Kaffey, Z, Abdelaal, MA, Spier, KB, West, NA, Marai, EG, Canahuate, GM, Zhang, X, Chen, MM, Wahid, K, Rigert, J, Hosseinian, S, Schaefer, AJ, Brock, K, Chambers, MS, Otun, AO, Aponte Wesson, R, Patel, V, Hope, A, Phan, J, Garden, AS, Frank, SJ, Morrison, WH, Spiotto, MT, Rosenthal, D, Lee, A, He, R, Naser, M, Watson, E, Hutcheson, KA, Mohamed, AS, Sandulache, VC, van Dijk, L, Moreno, AC, Guerrero Urbano, T, Fuller, C, Lai, SY. Externally validated digital decision support tool for time-to-osteoradionecrosis risk-stratification using right-censored multi-institutional observational cohorts. Radiotherapy and Oncology 207, 2025. e-Pub 2025. PMID: 40222595.
Odisio BC, Albuquerque J, Lin YM, Anderson BM, O'Connor CS, Rigaud B, Briones-Dimayuga M, Jones AK, Fellman BM, Huang SY, Kuban J, Metwalli ZA, Sheth R, Habibollahi P, Patel M, Shah KY, Cox VL, Kang HC, Morris VK, Kopetz S, Javle MM, Kaseb A, Tzeng CW, Cao HT, Newhook T, Chun YS, Vauthey JN, Gupta S, Paolucci I, Brock KK. Software-based versus visual assessment of the minimal ablative margin in patients with liver tumours undergoing percutaneous thermal ablation (COVER-ALL): a randomised phase 2 trial. Lancet Gastroenterol Hepatol 10(5):442-451, 2025. e-Pub 2025. PMID: 40090348.
Witztum A, Jourani Y, Hirata EY, McNutt T, Purdie TG, Brock KK, Hong DS, Howard ME, Krauze AV, Balter PA, Stockham AL, Covington E, Xiao Y, Popple R, Mayo CS. Best practice guidelines for use of reference points in radiation oncology information. Pract Radiat Oncol 15(3):290-299, 2025. e-Pub 2025. PMID: 39542396.
Jiwani, R, Pal, K, Paolucci, I, Odisio, BC, Brock, K, Tannir, NM, Shapiro, DD, Msaouel, P, Sheth, RA. Differentiating between renal medullary and clear cell renal carcinoma with a machine learning radiomics approach. Oncologist 30(2), 2025. e-Pub 2025. PMID: 39963829.
Nosrat, F, Dede, C, McCullum, L, Garcia, R, Mohamed, AS, Scott, J, Bates, JE, McDonald, B, Wahid, K, Naser, M, He, R, Karagoz, A, Moreno, AC, van Dijk, L, Brock, K, Heukelom, J, Hosseinian, S, Hemmati, M, Schaefer, AJ, Fuller, C. Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints. Physics and Imaging in Radiation Oncology 33, 2025. e-Pub 2025. PMID: 40123771.
Snoddy EP, Tang TT, Fowlkes N, Huynh T, Brewer Savannah KJ, Contreras A, Reece G, Brock KK. Development of an H&E on-block staining technique for collagen detection in cryo-fluorescence tomography imaging of frozen breast tissue samples. medRxiv, 2024. e-Pub 2024. PMID: 39763534.
Zhao, Y, Cozma, A, Ding, Y, Perles, LA, Reiazi, R, Chen, X, Kang, AM, Prajapati, S, Yu, H, Subashi, ED, Brock, K, Wang, J, Beddar, S, Lee, B, Mohammedsaid, M, Cooper, S, Westley, RL, Tree, A, Mohamad, O, Hassanzadeh, CJ, Mok, H, Choi, S, Tang, C, Yang, J. Upper Urinary Tract Stereotactic Body Radiotherapy Using a 1.5 Tesla Magnetic Resonance Imaging-Guided Linear Accelerator. Cancers 16(23), 2024. e-Pub 2024. PMID: 39682173.
Nosrat F, Dede C, McCullum LB, Garcia R, Mohamed ASR, Scott JG, Bates JE, McDonald BA, Wahid KA, Naser MA, He R, Karagoz A, Moreno AC, van Dijk LV, Brock KK, Heukelom J, Hosseinian S, Hemmati M, Schaefer AJ, Fuller CD. Optimal Timing of Organs-at-Risk-Sparing Adaptive Radiation Therapy for Head- and-Neck Cancer under Re-planning Resource Constraints. medRxiv, 2024. e-Pub 2024. PMID: 39417124.
Awais M, Al Taie M, O'Connor CS, Castelo AH, Acidi B, Tran Cao HS, Brock KK. Enhancing surgical guidance: Deep learning-based liver vessel segmentation in real-time ultrasound video frames. Cancers (Basel) 16(21):3674, 2024. e-Pub 2024. PMID: 39518111.
Woodland M, Castelo A, Al Taie M, Albuquerque Marques Silva J, Eltaher M, Mohn F, Shieh A, Kundu S, Yung JP, Patel AB, Brock KK. Feature Extraction for Generative Medical Imaging Evaluation: New Evidence Against an Evolving Trend. Lecture Notes in Computer Science 15012:87-97, 2024. e-Pub 2024.
Kamel S, Humbert-Vidan L, Kaffey Z, Abusaif A, Fuentes DTA, Wahid K, Dede C, Naser MA, He R, Moawad AW, Elsayes KM, Chen MM, Otun AO, Rigert J, Chambers M, Hope A, Watson E, Brock KK, Hutcheson K, van Dijk L, Moreno AC, Lai SY, Fuller CD, Mohamed ASR. Computed tomography radiomics-based cross-sectional detection of mandibular osteoradionecrosis in head and neck cancer survivors. medRxiv, 2024. e-Pub 2024. PMID: 39314948.
Patel, N, Celaya, A, Eltaher, M, Glenn, R, Savannah, KJ, Brock, K, Sanchez, JI, Calderone, T, Cleere, D, Elsaiey, A, Cagley, MC, Gupta, N, Victor, DW, Beretta, L, Koay, EJ, Netherton, T, Fuentes, DA. Training robust T1-weighted magnetic resonance imaging liver segmentation models using ensembles of datasets with different contrast protocols and liver disease etiologies. Scientific reports 14(1):20988, 2024. e-Pub 2024. PMID: 39251664.
Paolucci I, Albuquerque Marques Silva J, Lin YM, Laimer G, Cignini V, Menchini F, Meira M, Shieh A, O'Connor C, Jones KA, Gazzera C, Fonio P, Brock KK, Calandri M, Menezes M, Bale R, Odisio BC. Identification of A0 minimum ablative margins for colorectal liver metastases. Br J Surg 111(9):znae165, 2024. e-Pub 2024. PMID: 39213397.
Hurkmans C, Bibault JE, Brock KK, van Elmpt W, Feng M, David Fuller C, Jereczek-Fossa BA, Korreman S, Landry G, Madesta F, Mayo C, McWilliam A, Moura F, Muren LP, El Naqa I, Seuntjens J, Valentini V, Velec M. A joint ESTRO and AAPM guideline for development, clinical validation and reporting of artificial intelligence models in radiation therapy. Radiother Oncol 197:110345, 2024. e-Pub 2024. PMID: 38838989.
Whelan BM, Brock KK, Li Z. Software from publicly funded research should be free and open source for research. Med Phys 51(7):4550-4553, 2024. e-Pub 2024. PMID: 38703398.
Heshmat A, O'Connor CS, Albuquerque Marques Silva J, Paolucci I, Jones AK, Odisio BC, Brock KK. Using Patient-Specific 3D Modeling and Simulations to Optimize Microwave Ablation Therapy for Liver Cancer. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893214.
Lin YM, Paolucci I, Albuquerque Marques Silva J, O'Connor CS, Fellman BM, Jones AK, Kuban JD, Huang SY, Metwalli ZA, Brock KK, Odisio BC. Intraprocedural Versus Initial Follow-up Minimal Ablative Margin Assessment After Colorectal Liver Metastasis Thermal Ablation: Which One Better Predicts Local Outcomes?. Invest Radiol 59(4):314-319, 2024. e-Pub 2024. PMID: 37812469.
Albuquerque J, Lin YM, Paolucci I, O'Connor CS, Tzeng CW, Vauthey JN, Brock KK, Odisio BC. Incidental Ring-hyperenhancing Liver Micronodules at CT Hepatic Arteriography-guided Percutaneous Thermal Ablation of Colorectal Liver Metastases. Radiol Imaging Cancer 6(2):e230099, 2024. e-Pub 2024. PMID: 38363196.
Gupta AC, Cazoulat G, Al Taie M, Yedururi S, Rigaud B, Castelo A, Wood J, Yu C, O'Connor C, Salem U, Silva JAM, Jones AK, McCulloch M, Odisio BC, Koay EJ, Brock KK. Fully automated deep learning based auto-contouring of liver segments and spleen on contrast-enhanced CT images. Sci Rep 14(1):4678, 2024. e-Pub 2024. PMID: 38409252.
Lin YM, Paolucci I, Albuquerque Marques Silva J, O'Connor CS, Hong J, Shah KY, Abdelsalam ME, Habibollahi P, Jones KA, Brock KK, Odisio BC. Ablative margin quantification using deformable versus rigid image registration in colorectal liver metastasis thermal ablation: a retrospective single-center study. Eur Radiol. e-Pub 2024. PMID: 38334762.
He Y, Cazoulat G, Wu C, Svensson S, Almodovar-Abreu L, Rigaud B, McCollum E, Peterson C, Wooten Z, Rhee DJ, Balter P, Pollard-Larkin J, Cardenas C, Court L, Liao Z, Mohan R, Brock KK. Quantifying the Effect of 4-Dimensional Computed Tomography-Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 118(1):231-241, 2024. e-Pub 2024. PMID: 37552151.
McDonald BA, Cardenas CE, O'Connell N, Ahmed S, Naser MA, Wahid KA, Xu J, Thill D, Zuhour RJ, Mesko S, Augustyn A, Buszek SM, Grant S, Chapman BV, Bagley AF, He R, Mohamed ASR, Christodouleas J, Brock KK, Fuller CD. Investigation of autosegmentation techniques on T2-weighted MRI for off-line dose reconstruction in MR-linac workflow for head and neck cancers. Med Phys 51(1):278-291, 2024. e-Pub 2024. PMID: 37475466.
Paolucci I, Albuquerque Marques Silva J, Lin YM, Fellman BM, Jones KA, Tatsui CE, Weinberg JS, Ruiz J, Tan J, Brock KK, Bale R, Odisio BC. Study Protocol STEREOLAB: Stereotactic Liver Ablation Assisted with Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment. Cardiovasc Intervent Radiol 46(12):1748-1754, 2023. e-Pub 2023. PMID: 37563313.
Gay SS, Kisling KD, Anderson BM, Zhang L, Rhee DJ, Nguyen C, Netherton T, Yang J, Brock KK, Jhingran A, Simonds H, Klopp A, Beadle BM, Court LE, Cardenas CE. Identifying the optimal deep learning architecture and parameters for automatic beam aperture definition in 3D radiotherapy. J Appl Clin Med Phys 24(12):e14131, 2023. e-Pub 2023. PMID: 37670488.
Mayo CS, Feng MU, Brock KK, Kudner R, Balter P, Buchsbaum JC, Caissie A, Covington E, Daugherty EC, Dekker AL, Fuller CD, Hallstrom AL, Hong DS, Hong JC, Kamran SC, Katsoulakis E, Kildea J, Krauze AV, Kruse JJ, McNutt T, Mierzwa M, Moreno A, Palta JR, Popple R, Purdie TG, Richardson S, Sharp GC, Satomi S, Tarbox LR, Venkatesan AM, Witztum A, Woods KE, Yao Y, Farahani K, Aneja S, Gabriel PE, Hadjiiski L, Ruan D, Siewerdsen JH, Bratt S, Casagni M, Chen S, Christodouleas JC, DiDonato A, Hayman J, Kapoor R, Kravitz S, Sebastian S, Von Siebenthal M, Bosch W, Hurkmans C, Yom SS, Xiao Y. Operational Ontology for Oncology (O3) - A Professional Society Based, Multi-Stakeholder, Consensus Driven Informatics Standard Supporting Clinical and Research use of "Real -World" Data from Patients Treated for Cancer: Operational Ontology for Radiation Oncology. Int J Radiat Oncol Biol Phys 117(3):533-550, 2023. e-Pub 2023. PMID: 37244628.
Paolucci I, Lin YM, Albuquerque Marques Silva J, Brock KK, Odisio BC. Bayesian parametric models for survival prediction in medical applications. BMC Med Res Methodol 23(1):250, 2023. e-Pub 2023. PMID: 37884857.
Cazoulat G, Gupta AC, Al Taie MM, Koay EJ, Brock KK. Analysis and prediction of liver volume change maps derived from computational tomography scans acquired pre- and post-radiation therapy. Phys Med Biol 68(20), 2023. e-Pub 2023. PMID: 37714187.
Noh, S, Bertini, CD, Mira-Avendano, I, Kaous, M, Patel, B, Faiz, S, Shannon, VR, Balachandran, D, Bashoura, L, Adachi, R, Evans, S, Dickey, BF, Wu, CC, Shroff, G, Manzano, JM, Granwehr, BP, Holloway, S, Dickson, KB, Mohammed, AD, Muthu, M, Song, H, Aroe, A, Aloia, TA, Lee Andrews, II, Badami, KK, Beird, H, Brock, K, Cata, JP, Dabaja, BS, Draetta, G, French, KE, Godoy, M, Hutcheson, KA, Jaffray, D, John, TM, Lee, JJ, Litton, J, McEnery, KW, Musunuru, TN, Nates, JL, Palaskas, NL, Ravi, V, Scheet, PA, Shete, S, Subbiah, IM, Tawbi, H, Woodman, SE, Chung, C, Khawaja, F, Sheshadri, A. Interstitial lung abnormalities after hospitalization for COVID-19 in patients with cancer. Cancer medicine 12(17):17753-17765, 2023. e-Pub 2023. PMID: 37592894.
Moreno A, Solanki AA, Xu T, Lin R, Palta J, Daugherty E, Hong D, Hong J, Kamran SC, Katsoulakis E, Brock KK, Feng M, Fuller C, Mayo C, Cancer Consortium BP. Identification of Key Elements in Prostate Cancer for Ontology Building via a Multidisciplinary Consensus Agreement. Cancers (Basel) 15(12), 2023. e-Pub 2023. PMID: 37370731.
Jeun R, Iyer PC, Best C, Lavis V, Varghese JM, Yedururi S, Brady V, Glitza Oliva IC, Dadu R, Milton DR, Brock K, Thosani S. Clinical outcomes of immune checkpoint inhibitor diabetes mellitus at a comprehensive cancer center. Immunotherapy 15(6):417-428, 2023. e-Pub 2023. PMID: 37013834.
Lin YM, Paolucci I, O'Connor CS, Anderson BM, Rigaud B, Fellman BM, Jones KA, Brock KK, Odisio BC. Ablative Margins of Colorectal Liver Metastases Using Deformable CT Image Registration and Autosegmentation. Radiology 307(2):221373, 2023. e-Pub 2023. PMID: 36719291.
Reddy, DS, Cuenca, JA, Botdorf, JS, Muthu, M, Hanmandlu, A, Wegner, RC, Crommett, JW, Gutierrez, C, Rathi, N, Sajith, B, Knafl, M, Abbas, HA, Woodman, SE, Nates, JL, Aaroe, AE, Aloia, TA, Andrews, L, Badami, KK, Baganz, JA, Bajwa, P, Baker, LR, Barbosa, GR, Beird, H, Bourgeois, M, Brock, K, Burton, EM, Cata, JP, Chung, C, Cutherell, M, Dabaja, BS, Draetta, G, French, KE, Futreal, A, Gibbons, C, Godoy, M, Gunther, J, Hutcheson, KA, Jaffray, D, John, TM, Lee, JJ, Litton, J, McEnery, KW, Palaskas, NL, Ravi, V, Scheet, PA, Schmidt, S, Subbiah, IM, Tawbi, H, Wu, J, Yao, JC. Clinical Characteristics and Cause of Death Among Hospitalized Decedents With Cancer and COVID-19. Mayo Clinic Proceedings 98(3):451-457, 2023. e-Pub 2023. PMID: 36868753.
Paolucci I, Lin YM, Jones AK, Brock KK, Odisio BC. Use of Contrast Media During CT-guided Thermal Ablation of Colorectal Liver Metastasis for Procedure Planning is Associated with Improved Immediate Outcomes. Cardiovasc Intervent Radiol 46(3):327-336, 2023. e-Pub 2023. PMID: 36609863.
Paolucci I, Lin YM, Kawaguchi Y, Maki H, Jones AK, Calandri M, Kopetz S, Newhook TE, Brock KK, Vauthey JN, Odisio BC. Targeted exome-based predictors of patterns of progression of colorectal liver metastasis after percutaneous thermal ablation. Br J Cancer 128(1):130-136, 2023. e-Pub 2023. PMID: 36319850.
He Y, Anderson BM, Cazoulat G, Rigaud B, Almodovar-Abreu L, Pollard-Larkin J, Balter P, Liao Z, Mohan R, Odisio B, Svensson S, Brock KK. Optimization of mesh generation for geometric accuracy, robustness, and efficiency of biomechanical-model-based deformable image registration. Med Phys 50(1):323-329, 2023. e-Pub 2023. PMID: 35978544.
Jacobsen MC, Rigaud B, Simiele SJ, Rauch GM, Ning MS, Vedam S, Klopp AH, Stafford RJ, Brock KK, Venkatesan AM. Feasibility of quantitative diffusion-weighted imaging during intra-procedural MRI-guided brachytherapy of locally advanced cervical and vaginal cancers. Brachytherapy 22(6):736-745, 2023. e-Pub 2023. PMID: 37612174.
Reber B, Van Dijk L, Anderson B, Mohamed ASR, Fuller C, Lai S, Brock K. Comparison of Machine-Learning and Deep-Learning Methods for the Prediction of Osteoradionecrosis Resulting From Head and Neck Cancer Radiation Therapy. Adv Radiat Oncol 8(4):101163, 2023. e-Pub 2023. PMID: 36798732.
Lin YM, Paolucci I, Anderson BM, O'Connor CS, Rigaud B, Briones-Dimayuga M, Jones KA, Brock KK, Fellman BM, Odisio BC. Study Protocol COVER-ALL: Clinical Impact of a Volumetric Image Method for Confirming Tumour Coverage with Ablation on Patients with Malignant Liver Lesions. Cardiovasc Intervent Radiol 45(12):1860-1867, 2022. e-Pub 2022. PMID: 36058995.
Aminu M, Yadav D, Hong L, Young E, Edelkamp P, Saad M, Salehjahromi M, Chen P, Sujit SJ, Chen MM, Sabloff B, Gladish G, de Groot PM, Godoy MCB, Cascone T, Vokes NI, Zhang J, Brock KK, Daver N, Woodman SE, Tawbi HA, Sheshadri A, Lee JJ, Jaffray D, Team D, Wu CC, Chung C, Wu J. Habitat Imaging Biomarkers for Diagnosis and Prognosis in Cancer Patients Infected with COVID-19. Cancers (Basel) 15(1), 2022. e-Pub 2022. PMID: 36612278.
Owens CA, Rigaud B, Ludmir EB, Gupta AC, Shrestha S, Paulino AC, Smith SA, Peterson CB, Kry SF, Lee C, Henderson TO, Armstrong GT, Brock KK, Howell RM. Development and validation of a population-based anatomical colorectal model for radiation dosimetry in late effects studies of survivors of childhood cancer. Radiother Oncol 176:118-126, 2022. e-Pub 2022. PMID: 36063983.
He Y, Adair AH, Cazoulat G, Yepes P, Titt U, Wu C, Mirkovic D, Balter P, Pollard JM, Cardenas C, Liao Z, Mohan R, Brock K. Modeling Variable Proton Relative Biological Effectiveness (RBE) Using Voxel-Level Image Density Change for Non-Small Cell Lung Cancer (NSCLC) Patients Treated with Passive Scattering Proton Therapy (PSPT) or Intensity Modulated Photon Therapy (IMRT) 114(3):e506, 2022. e-Pub 2022.
Rigaud B, Weaver OO, Dennison JB, Awais M, Anderson BM, Chiang TD, Yang WT, Leung JWT, Hanash SM, KK Brock. Deep Learning Models for Automated Assessment of Breast Density Using Multiple Mammographic Image Types. Cancers (Basel) 14(20), 2022. e-Pub 2022. PMID: 36291787.
Rhee DJ, Akinfenwa CPA, Rigaud B, Jhingran A, Cardenas CE, Zhang L, Prajapati S, Kry SF, KK Brock, Beadle BM, Shaw W, O'Reilly F, Parkes J, Burger H, Fakie N, Trauernicht C, Simonds H, Court LE. Automatic contouring QA method using a deep learning-based autocontouring system. J Appl Clin Med Phys 23(8):e13647, 2022. e-Pub 2022. PMID: 35580067.
Paolucci I, Lin Y, Jones A, Brock K, Odisio B. Abstract No. 130 The added value of intra-procedural contrast-enhanced CT prior to thermal ablation of colorectal liver metastasis. Journal of Vascular and Interventional Radiology(6):S61, 2022. e-Pub 2022.
Woodland M, Wood J, Anderson B, Kundu S, Lin E, Koay E, Odisio B, Chung C, Kang H, Venkatesan A, Yedururi S, De B, Lin Y, Patel A, Brock K. Comparing Transfer Learning, Data Augmentation, and Data Expansion in the Improvement of Medical Image Generation. Medical Physics 49(6):E134-E134, 2022. e-Pub 2022.
Gupta A, Rigaud B, Yedururi S, Kirimli E, Yu C, He Y, Cazoulat G, Oconnor C, Odisio B, Koay E, Brock K. Evaluation of Deep Learning Based Auto-Contouring of Liver Segments 49(6):E697-E698, 2022. e-Pub 2022.
Owens C, Rigaud B, Ludmir E, Gupta A, Shrestha S, Paulino A, Peterson C, Kry S, Smith S, Brock K, Henderson T, Howell R. OC-0939 Development and validation of a population-based colorectal model for radiation therapy dosimetry. Radiotherapy and Oncology:S830-S832, 2022. e-Pub 2022.
Singh BS, Cazacu IM, Deza CA, Rigaud BS, Saftoiu A, Gruionu G, Guionu L, Brock KK, Koay EJ, Herman JM. Image Fusion Involving Real-Time Transabdominal or Endoscopic Ultrasound for Gastrointestinal Malignancies: Review of Current and Future Applications. Diagnostics 2022, 12, 3218 12(18), 2022. e-Pub 2022.
McCulloch MM, Cazoulat G, Svensson S, Gryshkevych S, Rigaud B, Anderson BM, Kirimli E, De B, Mathew RT, Zaid M, Elganainy D, Peterson CB, Balter P, Koay EJ, KK B. Leveraging deep learning-based segmentation and contours-driven deformable registration for dose accumulation in abdominal structures. Front Oncol 12:1015608, 2022. e-Pub 2022. PMID: 36408172.
Anderson BM, Rigaud B, Lin YM, Jones AK, Kang HC, Odisio BC, KK B. Automated segmentation of colorectal liver metastasis and liver ablation on contrast-enhanced CT images. Front Oncol 12:886517, 2022. e-Pub 2022. PMID: 36033508.
Lin YM, Bale R, Brock KK, Odisio BC. Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment. Int J Hyperthermia 39(1):649-663, 2022. e-Pub 2022. PMID: 35465805.
Sen A, Fowlkes NW, Kingsley CV, Kulp AM, Huynh T, Willis BJ, Brewer Savannah KJ, Bordes MCA, Hwang KP, McCulloch MM, Stafford RJ, Contreras A, Reece G, Brock KK. Technical note: Histological validation of anatomical imaging for breast modeling using a novel cryo-microtome. Med Phys 48(11):7323-7332, 2021. e-Pub 2021. PMID: 34559413.
Lesage AC, Simmons A, Sen A, Singh S, Chen M, Cazoulat G, Weinberg JS, KK B. Viscoelastic biomechanical models to predict inward brain-shift using public benchmark data. Phys Med Biol 66(20), 2021. e-Pub 2021. PMID: 34469879.
Anderson BM, Lin YM, Lin EY, Cazoulat G, Gupta S, Kyle Jones A, Odisio BC, KK B. A novel use of biomechanical model-based deformable image registration (DIR) for assessing colorectal liver metastases ablation outcomes. Med Phys 48(10):6226-6236, 2021. e-Pub 2021. PMID: 34342018.
Cazoulat G, Anderson BM, McCulloch MM, Rigaud B, Koay EJ, KK B. Detection of vessel bifurcations in CT scans for automatic objective assessment of deformable image registration accuracy. Med Phys 48(10):5935-5946, 2021. e-Pub 2021. PMID: 34390007.
He Y, Cazoulat G, Wu C, Peterson C, McCulloch M, Anderson B, Pollard-Larkin J, Balter P, Liao Z, Mohan R, Brock K. Geometric and dosimetric accuracy of deformable image registration between average-intensity images for 4DCT-based adaptive radiotherapy for non-small cell lung cancer. J Appl Clin Med Phys 22(8):156-167, 2021. e-Pub 2021. PMID: 34310827.
Thrower SL, Al Feghali KA, Luo D, Paddick I, Hou P, Briere T, Li J, McAleer MF, McGovern SL, Woodhouse KD, Yeboa DN, Brock KK, Chung C. The Effect of Slice Thickness on Contours of Brain Metastases for Stereotactic Radiosurgery. Adv Radiat Oncol 6(4):100708, 2021. e-Pub 2021. PMID: 34124413.
Anderson BM, Wahid KA, Brock KK. Simple Python Module for Conversions between DICOM Images and Radiation Therapy Structures, Masks, and Prediction Arrays. Pract Radiat Oncol 11(3):226-229, 2021. e-Pub 2021. PMID: 33607331.
Rigaud B, Anderson BM, Yu ZH, Gobeli M, Cazoulat G, Söderberg J, Samuelsson E, Lidberg D, Ward C, Taku N, Cardenas C, Rhee DJ, Venkatesan AM, Peterson CB, Court L, Svensson S, Löfman F, Klopp AH, Brock KK. Automatic Segmentation Using Deep Learning to Enable Online Dose Optimization During Adaptive Radiation Therapy of Cervical Cancer. Int J Radiat Oncol Biol Phys 109(4):1096-1110, 2021. e-Pub 2021. PMID: 33181248.
Lee M, Simeonov A, Stanescu T, Dawson LA, Brock KK, Velec M. MRI evaluation of normal tissue deformation and breathing motion under an abdominal compression device. J Appl Clin Med Phys 22(2):90-97, 2021. e-Pub 2021. PMID: 33449447.
Cazoulat G, Balter JM, Matuszak MM, Jolly S, Owen D, Brock KK. Mapping lung ventilation through stress maps derived from biomechanical models of the lung. Med Phys 48(2):715-723, 2021. e-Pub 2021. PMID: 33617034.
Anderson BM, Lin EY, Cardenas CE, Gress DA, Erwin WD, Odisio BC, Koay EJ, Brock KK. Automated Contouring of Contrast and Noncontrast Computed Tomography Liver Images With Fully Convolutional Networks. Adv Radiat Oncol 6(1):100464, 2021. e-Pub 2021. PMID: 33490720.
Dominello MM, Sanders T, Anscher M, Bayouth J, Brock KK, Carlson DJ, Hugo G, Joseph S, Knisely J, Mendonca MS, Mian OY, Moros EG, Singh AK, Yu JB. Responses to the 2018 and 2019 "One Big Discovery" Question: ASTRO Membership's Opinions on the Most Important Research Question Facing Radiation Oncology…Where Are We Headed?. Int J Radiat Oncol Biol Phys 109(1):38-40, 2021. e-Pub 2021. PMID: 32798605.
Rhee DJ, Jhingran A, Rigaud B, Netherton T, Cardenas CE, Zhang L, Vedam S, Kry S, Brock KK, Shaw W, O'Reilly F, Parkes J, Burger H, Fakie N, Trauernicht C, Simonds H, Court LE. Automatic contouring system for cervical cancer using convolutional neural networks. Med Phys 47(11):5648-5658, 2020. e-Pub 2020. PMID: 32964477.
Yu JB, Brock KK, Campbell AM, Chen AB, Diaz R, Escorcia FE, Gupta G, Hrinivich WT, Joseph S, Korpics M, Onderdonk BE, Pandit-Taskar N, Wood BJ, Woodward WA. Proceedings of the ASTRO-RSNA Oligometastatic Disease Research Workshop. Int J Radiat Oncol Biol Phys 108(3):539-545, 2020. e-Pub 2020. PMID: 32434040.
Lesage AJ, Rajaram R, Tam AL, Rigaud BS, Brock KK, Rice DC, Cazoulat G. Preliminary evaluation of biomechanical modeling of lung deflation during minimally invasive surgery using pneumothorax computed tomography scans. Phys Med Biol 65(22):22510. e-Pub 2020. PMID: 32906090.
McCulloch MM, Cazoulat G, Ford AC, Elgohari B, Bahig H, Kim AD, Elhalawani H, He R, Wang J, Ding Y, Mohamed AS, Polan DF, King JB, Peterson CB, Ohrt AN, Fuller CD, Lai SY, Brock KK. Biomechanical modeling of radiation dose-induced volumetric changes of the parotid glands for deformable image registration. Phys Med Biol 65(16):165017, 2020. e-Pub 2020. PMID: 32320955.
Pursley J, El Naqa I, Sanford NN, Noe B, Wo JY, Eyler CE, Hwang M, Brock KK, Yeap BY, Wolfgang JA, Hong TS, Grassberger C. Dosimetric analysis and normal tissue complication probability modeling of Child-Pugh score and Albumin-Bilirubin grade increase after hepatic irradiation. Int J Radiat Oncol Biol Phys 107(5):986-995, 2020. e-Pub 2020. PMID: 32353390.
Parsai S, Qiu RLJ, Qi P, Alfonso JCL, Donaghue J, Murray E, Majkszak D, Dorio N, Fuller CD, Brock K, Koyfman S, Woody N, Joshi N, Scott JG. Technical Note: A step-by-step guide to Temporally Feathered Radiation Therapy planning for head and neck cancer. J Appl Clin Med Phys 21(7):209-215. e-Pub 2020. PMID: 32383296.
Rigaud B, Cazoulat G, Vedam S, Venkatesan AM, Peterson CB, Taku N, Klopp AH, KK B. Modeling Complex Deformations of the Sigmoid Colon Between External Beam Radiation Therapy and Brachytherapy Images of Cervical Cancer. Int J Radiat Oncol Biol Phys 106(5):1084-1094, 2020. e-Pub 2020. PMID: 32029345.
Sen A, Anderson BM, Cazoulat G, McCulloch MM, Elganainy D, McDonald BA, He Y, Mohamed ASR, Elgohari BA, Zaid M, Koay EJ, Brock KK. Accuracy of deformable image registration techniques for alignment of longitudinal cholangiocarcinoma CT images. Med Phys 47(4):1670-1679, 2020. e-Pub 2020. PMID: 31958147.
Green CA, Goodsitt MM, Lau JH, KK B, Davis CL, Carson PL. Deformable Mapping Method to Relate Lesions in Dedicated Breast CT Images to Those in Automated Breast Ultrasound and Digital Breast Tomosynthesis Images. Ultrasound Med Biol 46(3):750-765, 2020. e-Pub 2020. PMID: 31806500.
Jin Y, Randall JW, Elhalawani H, Feghali KAA, Elliott AM, Anderson BM, Lacerda L, Tran BL, Mohamed AS, KK B, Fuller CD, Chung C. Detection of Glioblastoma Subclinical Recurrence Using Serial Diffusion Tensor Imaging. Cancers (Basel) 12(3), 2020. e-Pub 2020. PMID: 32121471.
Green CA, Goodsitt MM, Roubidoux MA, Brock KK, Davis CL, Lau JH, Carson PL. Deformable mapping using biomechanical models to relate corresponding lesions in digital breast tomosynthesis and automated breast ultrasound images. Med Image Anal 60:101599, 2020. e-Pub 2020. PMID: 31760192.
Cazoulat G, Elganainy D, Anderson BM, Zaid M, Park PC, Koay EJ, KK B. Vasculature-Driven Biomechanical Deformable Image Registration of Longitudinal Liver Cholangiocarcinoma Computed Tomographic Scans. Adv Radiat Oncol 5(2):269-278, 2020. e-Pub 2020. PMID: 32280827.
Horie M, Levy L, Houbois C, Salazar P, Saito T, Pakkal M, O'Brien C, Sajja S, KK Brock, Yasufuku K, Keshavjee S, Paul N, Martinu T. Lung Density Analysis Using Quantitative Chest CT for Early Prediction of Chronic Lung Allograft Dysfunction. Transplantation 103(12):2645-2653, 2019. e-Pub 2019. PMID: 31343572.
McCulloch MM, Anderson BM, Cazoulat G, Peterson CB, Mohamed ASR, Volpe S, Elhalawani H, Bahig H, Rigaud B, King JB, Ford AC, Fuller CD, KK B. Biomechanical modeling of neck flexion for deformable alignment of the salivary glands in head and neck cancer images. Phys Med Biol 64(17):175018, 2019. e-Pub 2019. PMID: 31269475.
Head J, Development Cooperative NM, Kiser K, Meheissen MAM, Mohamed ASR, Kamal M, Ng SP, Elhalawani H, Jethanandani A, He R, Ding Y, Rostom Y, Hegazy N, Bahig H, Garden A, Lai S, Phan J, Gunn GB, Rosenthal D, Frank S, KK B, Wang J, Fuller CD. Prospective quantitative quality assurance and deformation estimation of MRI-CT image registration in simulation of head and neck radiotherapy patients. Clin Transl Radiat Oncol 18:120-127, 2019. e-Pub 2019. PMID: 31341987.
KK B. Adaptive Radiotherapy: Moving into the Future. Semin Radiat Oncol 29(3):181-184, 2019. e-Pub 2019. PMID: 31027635.
Yang Z, Chang Y, KK B, Cazoulat G, Koay EJ, Koong AC, Herman JM, Park PC, Poenisch F, Li Q, Yang K, Wu G, Anderson B, Ohrt AN, Li Y, Zhu XR, Zhang X, Li H. Effect of setup and inter-fraction anatomical changes on the accumulated dose in CT-guided breath-hold intensity modulated proton therapy of liver malignancies. Radiother Oncol 134:101-109, 2019. e-Pub 2019. PMID: 31005203.
Rigaud B, Klopp A, Vedam S, Venkatesan A, Taku N, Simon A, Haigron P, de Crevoisier R, KK B, Cazoulat G. Deformable image registration for dose mapping between external beam radiotherapy and brachytherapy images of cervical cancer. Phys Med Biol 64(11):115023, 2019. e-Pub 2019. PMID: 30913542.
Kipritidis J, Tahir BA, Cazoulat G, Hofman MS, Siva S, Callahan J, Hardcastle N, Yamamoto T, Christensen GE, Reinhardt JM, Kadoya N, Patton TJ, Gerard SE, Duarte I, Archibald-Heeren B, Byrne M, Sims R, Ramsay S, Booth JT, Eslick E, Hegi-Johnson F, Woodruff HC, Ireland RH, Wild JM, Cai J, Bayouth JE, KK Brock, Keall PJ. The VAMPIRE Challenge: A Multi-Institutional Validation Study of CT Ventilation Imaging. Med Phys 46(3):1198-1217, 2019. e-Pub 2019. PMID: 30575051.
Yu JB, Beck TF, Anscher MS, Baschnagel AM, KK B, Carlson DJ, Dominello MM, Kimple RJ, Knisely JP, Mendonca MS, Mian OY, Singh AK, Moros EG, Keen JC. Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio. Int J Radiat Oncol Biol Phys 103(2):297-304, 2019. e-Pub 2019. PMID: 30647006.
Yu JB, Beck TF, Anscher MS, Baschnagel AM, KK B, Carlson DJ, Dominello MM, Kimple RJ, Knisely JPS, Mendonca MS, Mian OY, Singh AK, Moros EG, Keen JC. The ASTRO Research Portfolio: Where Do We Go From Here?. Int J Radiat Oncol Biol Phys 103(2):308-309, 2019. e-Pub 2019. PMID: 30647008.
McCulloch MM, Lee C, Rosen BS, Kamp JD, Lockhart CM, Lee JY, Polan DF, Hawkins PG, Anderson CJR, Heukelom J, Sonke JJ, Fuller CD, Balter JM, Ten Haken RK, Eisbruch A, KK B. Predictive Models to Determine Clinically Relevant Deviations in Delivered Dose for Head and Neck Cancer. Pract Radiat Oncol 9(4):e422-e431, 2019. e-Pub 2019. PMID: 30836190.
Rosen BS, Hawkins PG, Polan DF, Balter JM, KK Brock, Kamp JD, Lockhart CM, Eisbruch A, Mierzwa ML, Ten Haken RK, El Naqa I. Early changes in serial CBCT-measured parotid gland biomarkers predict chronic xerostomia after head and neck radiotherapy. Int J Radiat Oncol Biol Phys 102(4):1319-1329, 2018. e-Pub 2018. PMID: 30003997.
KK B, Yom SS. Seeing What's Before Us: Imaging in the Electronic Age. Int J Radiat Oncol Biol Phys 102(4):675-676, 2018. e-Pub 2018. PMID: 30353874.
Bahig H, Yuan Y, Mohamed ASR, KK B, Ng SP, Wang J, Ding Y, Hutcheson K, McCulloch M, Balter PA, Lai SY, Al-Mamgani A, Sonke JJ, van der Heide UA, Nutting C, Li XA, Robbins J, Awan M, Karam I, Newbold K, Harrington K, Oelfke U, Bhide S, Philippens MEP, Terhaard CHJ, McPartlin AJ, Blanchard P, Garden AS, Rosenthal DI, Gunn GB, Phan J, Cazoulat G, Aristophanous M, McSpadden KK, Garcia JA, van den Berg CAT, Raaijmakers CPJ, Kerkmeijer L, Doornaert P, Blinde S, Frank SJ, Fuller CD. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial. Clin Transl Radiat Oncol 13:19-23, 2018. e-Pub 2018. PMID: 30386824.
Dominello MM, Keen JC, Beck TF, Bayouth J, Knisely J, Carlson DJ, Mendonca MS, Mian O, KK Brock, Anscher M, Hugo G, Moros EG, Singh AK, Yu JB. Responses to the 2017 '1 Million Gray Question': ASTRO membership's opinions on the most important research question facing radiation oncology. Int J Radiat Oncol Biol Phys 102(2):249-250, 2018. e-Pub 2018. PMID: 30003995.
Green CA, Goodsitt MM, KK B, Davis CL, Larson ED, Lau JH, Carson PL. Deformable mapping technique to correlate lesions in digital breast tomosynthesis and automated breast ultrasound images. Med Phys 45(10):4402-4417, 2018. e-Pub 2018. PMID: 30066340.
Mohamed ASR, Bahig H, Aristophanous M, Blanchard P, Kamal M, Ding Y, Cardenas CE, KK B, Lai SY, Hutcheson KA, Phan J, Wang J, Ibbott G, Gabr RE, Narayana PA, Garden AS, Rosenthal DI, Gunn GB, Fuller CD, Group MD. Prospective in silico study of the feasibility and dosimetric advantages of MRI-guided dose adaptation for human papillomavirus positive oropharyngeal cancer patients compared with standard IMRT. Clin Transl Radiat Oncol 11:11-18, 2018. e-Pub 2018. PMID: 30014042.
Horie M, Salazar P, Saito T, Binnie M, Brock KK, Yasufuku K, Azad S, Keshavjee S, Martinu T, Paul N. Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival. Clin Transplant 32(5):e13233, 2018. e-Pub 2018. PMID: 29637624.
El Naqa I, Brock KK, Yu Y, Langen K, Klein EE. On the Fuzziness of Machine Learning, Neural Networks, and Artificial Intelligence in Radiation Oncology. Int J Radiat Oncol Biol Phys 100(1):1-4, 2018. e-Pub 2018. PMID: 29254765.
McCulloch MM, Muenz DG, Schipper MJ, Velec M, Dawson LA, KK B. A simulation study to assess the potential impact of developing normal tissue complication probability models with accumulated dose. Adv Radiat Oncol 3(4):662-672, 2018. e-Pub 2018. PMID: 30370368.
Chapman CH, Polan D, Vineberg K, Jolly S, Maturen KE, KK B, Prisciandaro JI. Deformable image registration-based contour propagation yields clinically acceptable plans for MRI-based cervical cancer brachytherapy planning. Brachytherapy 17(2):360-367, 2018. e-Pub 2018. PMID: 29331573.
Chung C, Brock KK. Image-guided radiation therapy: looking beyond what we currently see. Future Oncol 13(26):2317-2319, 2017. e-Pub 2017. PMID: 29121781.
Polan DF, Feng M, Lawrence TS, Ten Haken RK, KK B. Implementing Radiation Dose-Volume Liver Response in Biomechanical Deformable Image Registration. Int J Radiat Oncol Biol Phys 99(4):1004-1012, 2017. e-Pub 2017. PMID: 28864401.
Pawlicki T, Ayers RG, Brock KK, Clements JB, Curran BH, Dobbins JT, Samei E, Adams E, Martin MC, Schober L. Proposed changes to the American Association of Physicists in Medicine governance. J Appl Clin Med Phys 18(4):4-6, 2017. e-Pub 2017. PMID: 28681449.
KK B, Mutic S, McNutt TR, Li H, Kessler ML. Use of image registration and fusion algorithms and techniques in radiotherapy: Report of the AAPM Radiation Therapy Committee Task Group No. 132. Med Phys 44(7):e43-e76, 2017. e-Pub 2017. PMID: 28376237.
Velec M, Moseley JL, Svensson S, Hårdemark B, Jaffray DA, Brock KK. Validation of Biomechanical Deformable Image Registration in the Abdomen, Thorax and Pelvis in a Commercial Radiotherapy Treatment Planning System. Med Phys 44(7):3407-3417, 2017. e-Pub 2017. PMID: 28453911.
McGrath DM, Lee J, Foltz WD, Samavati N, van der Kwast T, Jewett MA, Chung P, Ménard C, Brock KK. MR elastography to measure the effects of cancer and pathology fixation on prostate biomechanics, and comparison with T 1, T 2 and ADC. Phys Med Biol 62(3):1126-1148, 2017. e-Pub 2017. PMID: 28092638.
Liss AL, Marsh RB, Kapadia NS, McShan DL, Rogers VE, Balter JM, Moran JM, Brock KK, Schipper MJ, Jagsi R, Griffith KA, Flaherty KR, Frey KA, Pierce J. Decreased Lung Perfusion After Breast/Chest Wall Irradiation: Quantitative Results from a Prospective Clinical Trial. Int J Radiat Oncol Biol Phys 97(2):296-302, 2017. e-Pub 2017. PMID: 27986344.
Ma J, Moerland MA, Venkatesan AM, Bathala TK, Kudchadker RJ, Brock KK, Frank SJ. Pulse sequence considerations for simulation and postimplant dosimetry of prostate brachytherapy. Brachytherapy 16(4):743-753, 2017. e-Pub 2017. PMID: 28063817.
Samuels SE, Eisbruch A, Vineberg K, Lee J, Lee C, Matuszak MM, Ten Haken RK, Brock KK. Methods for Reducing Normal Tissue Complication Probabilities in Oropharyngeal Cancer: Dose Reduction or Planning Target Volume Elimination. Int J Radiat Oncol Biol Phys 96(3):645-52, 2016. e-Pub 2016. PMID: 27681761.
Klein EE, Brock KK, Fontenot J, Yu Y. Technical Advances in Oncology Outside of Radiation Medicine. Int J Radiat Oncol Biol Phys 95(5):1323-6, 2016. e-Pub 2016. PMID: 27479719.
Cazoulat G, Owen D, Matuszak MM, Balter JM, Brock KK. Biomechanical deformable image registration of longitudinal lung CT images using vessel information. Phys Med Biol 61(13):4826-39, 2016. e-Pub 2016. PMID: 27273115.
Coolens C, Driscoll B, Moseley J, Brock KK, Dawson LA. Feasibility of 4D perfusion CT imaging for the assessment of liver treatment response following SBRT and sorafenib. Adv Radiat Oncol 1(3):194-203, 2016. e-Pub 2016. PMID: 28740888.
McGrath DM, Lee J, Foltz WD, Samavati N, Jewett MA, van der Kwast T, Chung P, Ménard C, Brock KK. Technical Note: Method to correlate whole-specimen histopathology of radical prostatectomy with diagnostic MR imaging. Med Phys 43(3):1065-72, 2016. e-Pub 2016. PMID: 26936694.
Matuszak MM, Hadley SW, Feng M, Hayman JA, Brock KK, Burger P, Owen D, Suresh K, Schipper M, Lawrence TS, Moran JM. Enhancing safety and quality through preplanning peer review for patients undergoing stereotactic body radiation therapy. Pract Radiat Oncol 6(2):e39-46, 2016. e-Pub 2016. PMID: 26746815.
Swaminath A, Knox JJ, Brierley JD, Dinniwell R, Wong R, Kassam Z, Kim J, Coolens C, Brock KK, Dawson LA. Changes in Liver Volume Observed Following Sorafenib and Liver Radiation Therapy. Int J Radiat Oncol Biol Phys 94(4):729-37, 2016. e-Pub 2016. PMID: 26972645.
Samavati N, Velec M, Brock KK. Effect of deformable registration uncertainty on lung SBRT dose accumulation. Med Phys 43(1):233, 2016. e-Pub 2016. PMID: 26745916.
Swaminath A, Massey C, Brierley JD, Dinniwell R, Wong R, Kim JJ, Velec M, Brock KK, Dawson LA. Accumulated Delivered Dose Response of Stereotactic Body Radiation Therapy for Liver Metastases. Int J Radiat Oncol Biol Phys 93(3):639-48, 2015. e-Pub 2015. PMID: 26461006.
Al-Mayah A, Moseley J, Hunter S, Brock KK. Radiation dose response simulation for biomechanical-based deformable image registration of head and neck cancer treatment. Phys Med Biol 60(21):8481-9, 2015. e-Pub 2015. PMID: 26485227.
Velec M, Juang T, Moseley JL, Oldham M, Brock KK. Utility and validation of biomechanical deformable image registration in low-contrast images. Pract Radiat Oncol 5(4):e401-8, 2015. e-Pub 2015. PMID: 25823381.
Samavati N, Velec M, Brock K. A hybrid biomechanical intensity based deformable image registration of lung 4DCT. Phys Med Biol 60(8):3359-73, 2015. e-Pub 2015. PMID: 25830808.
Fontenot JD, Brock KK, Klein EE. What makes a physics article appealing to a clinical audience?. Int J Radiat Oncol Biol Phys 91(1):20-1, 2015. e-Pub 2015. PMID: 25835620.
Samavati N, McGrath DM, Jewett MA, van der Kwast T, Ménard C, Brock KK. Effect of material property heterogeneity on biomechanical modeling of prostate under deformation. Phys Med Biol 60(1):195-209, 2015. e-Pub 2015. PMID: 25489840.
Ménard C, Iupati D, Publicover J, Lee J, Abed J, O'Leary G, Simeonov A, Foltz WD, Milosevic M, Catton C, Morton G, Bristow R, Bayley A, Atenafu EG, Evans AJ, Jaffray DA, Chung P, Brock KK, Haider MA. MR-guided prostate biopsy for planning of focal salvage after radiation therapy. Radiology 274(1):181-91, 2015. e-Pub 2015. PMID: 25203127.
Klein EE, Brock KK, Fontenot JD, Yu Y. Oncology scan--bringing rapid learning and adaptive techniques into clinical physics. Int J Radiat Oncol Biol Phys 90(2):243-5, 2014. e-Pub 2014. PMID: 25304782.
Lim K, Stewart J, Kelly V, Xie J, Brock KK, Moseley J, Cho YB, Fyles A, Lundin A, Rehbinder H, Löf J, Jaffray DA, Milosevic M. Dosimetrically triggered adaptive intensity modulated radiation therapy for cervical cancer. Int J Radiat Oncol Biol Phys 90(1):147-54, 2014. e-Pub 2014. PMID: 25015200.
Wysocka B, Moseley J, Brock K, Lockwood G, Wilson G, Simeonov A, Haider MA, Menard C, Bissonnette JP, Dawson LA, Ringash J. Assessment of nonrespiratory stomach motion in healthy volunteers in fasting and postprandial states. Pract Radiat Oncol 4(5):288-93, 2014. e-Pub 2014. PMID: 25194096.
Velec M, Moseley JL, Dawson LA, Brock KK. Dose escalated liver stereotactic body radiation therapy at the mean respiratory position. Int J Radiat Oncol Biol Phys 89(5):1121-8, 2014. e-Pub 2014. PMID: 25035217.
KK Brock, Dawson LA. Point: Principles of magnetic resonance imaging integration in a computed tomography-based radiotherapy workflow. Semin Radiat Oncol 24(3):169-74, 2014. e-Pub 2014. PMID: 24931087.
Brock KK, Dawson LA. Point: Principles of magnetic resonance imaging integration in computed tomography-based radiotherapy workflow. Seminars in Radiation Oncology 24(3):169-174, 2014. e-Pub 2014.
Velec M, Moseley JL, Brock KK. Simplified strategies to determine the mean respiratory position for liver radiation therapy planning. Pract Radiat Oncol 4(3):160-6, 2014. e-Pub 2014. PMID: 24766682.
Oh S, Stewart J, Moseley J, Kelly V, Lim K, Xie J, Fyles A, Brock KK, Lundin A, Rehbinder H, Milosevic M, Jaffray D, Cho YB. Hybrid adaptive radiotherapy with on-line MRI in cervix cancer IMRT. Radiother Oncol 110(2):323-8, 2014. e-Pub 2014. PMID: 24331862.
Ng A, Brock KK, Sharpe MB, Moseley JL, Craig T, Hodgson DC. Individualized 3D reconstruction of normal tissue dose for patients with long-term follow-up: a step toward understanding dose risk for late toxicity. Int J Radiat Oncol Biol Phys 84(4):e557-63, 2012. e-Pub 2012. PMID: 22929861.
McGrath DM, Foltz WD, Al-Mayah A, Niu CJ, Brock KK. Quasi-static magnetic resonance elastography at 7 T to measure the effect of pathology before and after fixation on tissue biomechanical properties. Magn Reson Med 68(1):152-65, 2012. e-Pub 2012. PMID: 22213551.
Velec M, Moseley JL, Craig T, Dawson LA, Brock KK. Accumulated dose in liver stereotactic body radiotherapy: positioning, breathing, and deformation effects. Int J Radiat Oncol Biol Phys 83(4):1132-40, 2012. e-Pub 2012. PMID: 22208969.
Niu CJ, Foltz WD, Velec M, Moseley JL, Al-Mayah A, Brock KK. A novel technique to enable experimental validation of deformable dose accumulation. Med Phys 39(2):765-76, 2012. e-Pub 2012. PMID: 22320786.
Ng A, Nguyen TN, Moseley JL, Hodgson DC, Sharpe MB, Brock KK. Navigator channel adaptation to reconstruct three dimensional heart volumes from two dimensional radiotherapy planning data. BMC Med Phys 12:1, 2012. e-Pub 2012. PMID: 22257738.
Brock KK. Image and image-guided radiation therapy in liver cancer. Seminars in Radiation Oncology 21(4):247-255, 2011. e-Pub 2011.
Al-Mayah A, Moseley J, Velec M, Brock K. Toward efficient biomechanical-based deformable image registration of lungs for image-guided radiotherapy. Phys Med Biol 56(15):4701-13, 2011. e-Pub 2011. PMID: 21734336.
Eccles CL, Dawson LA, Moseley JL, Brock KK. Interfraction liver shape variability and impact on GTV position during liver stereotactic radiotherapy using abdominal compression. Int J Radiat Oncol Biol Phys 80(3):938-46, 2011. e-Pub 2011. PMID: 20947263.
Velec M, Moseley JL, Eccles CL, Craig T, Sharpe MB, Dawson LA, Brock KK. Effect of breathing motion on radiotherapy dose accumulation in the abdomen using deformable registration. Int J Radiat Oncol Biol Phys 80(1):265-72, 2011. e-Pub 2011. PMID: 20732755.
Brierley JD, Dawson LA, Sampson E, Bayley A, Scott S, Moseley JL, Craig T, Cummings B, Dinniwell R, Kim JJ, Ringash J, Wong R, Brock KK. Rectal motion in patients receiving preoperative radiotherapy for carcinoma of the rectum. Int J Radiat Oncol Biol Phys 80(1):97-102, 2011. e-Pub 2011. PMID: 21481722.
Nithiananthan S, Schafer S, Uneri A, Mirota DJ, Stayman JW, Zbijewski W, Brock KK, Daly MJ, Chan H, Irish JC, Siewerdsen JH. Demons deformable registration of CT and cone-beam CT using an iterative intensity matching approach. Med Phys 38(4):1785-98, 2011. e-Pub 2011. PMID: 21626913.
Samavati N, McGrath DM, Lee J, van Kwast T, Jewett M, Ménard C, Brock KK. Biomechanical model-based deformable registration of MRI and histopathology for clinical prostatectomy. J Pathol Inform 2:S10, 2011. e-Pub 2011. PMID: 22811954.
Al-Mayah A, Moseley J, Hunter S, Velec M, Chau L, Breen S, Brock K. Biomechanical-based image registration for head and neck radiation treatment. Phys Med Biol 55(21):6491-500, 2010. e-Pub 2010. PMID: 20959687.
Stewart J, Lim K, Kelly V, Xie J, Brock KK, Moseley J, Cho YB, Fyles A, Lundin A, Rehbinder H, Löf J, Jaffray D, Milosevic M. Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer. Int J Radiat Oncol Biol Phys 78(2):350-8, 2010. e-Pub 2010. PMID: 20832664.
Al-Mayah A, Moseley J, Velec M, Hunter S, Brock K. Deformable image registration of heterogeneous human lung incorporating the bronchial tree. Med Phys 37(9):4560-71, 2010. e-Pub 2010. PMID: 20964173.
Vlad RM, Kolios MC, Moseley JL, Czarnota GJ, Brock KK. Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology. Med Phys 37(8):4288-97, 2010. e-Pub 2010. PMID: 20879589.
Case RB, Moseley DJ, Sonke JJ, Eccles CL, Dinniwell RE, Kim J, Bezjak A, Milosevic M, Brock KK, Dawson LA. Interfraction and intrafraction changes in amplitude of breathing motion in stereotactic liver radiotherapy. Int J Radiat Oncol Biol Phys 77(3):918-25, 2010. e-Pub 2010. PMID: 20207501.
Alonzo-Proulx O, Packard N, Boone JM, Al-Mayah A, Brock KK, Shen SZ, Yaffe MJ. Validation of a method for measuring the volumetric breast density from digital mammograms. Phys Med Biol 55(11):3027-44, 2010. e-Pub 2010. PMID: 20463377.
McGrath DM, Vlad RM, Foltz WD, Brock KK. Technical note: fiducial markers for correlation of whole-specimen histopathology with MR imaging at 7 tesla. Med Phys 37(5):2321-8, 2010. e-Pub 2010. PMID: 20527566.
Brock KK, Dawson LA. Adaptive management of liver cancer radiotherapy. Seminars in Radiation Oncology 20(2):107-115, 2010. e-Pub 2010.
MacFadden D, Zhang B, Brock KK, Hodaie M, Laperriere N, Schwartz M, Tsao M, Stainsby J, Lockwood G, Mikulis D, Ménard C. Clinical evaluation of stereotactic target localization using 3-Tesla MRI for radiosurgery planning. Int J Radiat Oncol Biol Phys 76(5):1472-9, 2010. e-Pub 2010. PMID: 19515512.
Ng A, Nguyen TN, Moseley JL, Hodgson DC, Sharpe MB, Brock KK. Reconstruction of 3D lung models from 2D planning data sets for Hodgkin's lymphoma patients using combined deformable image registration and navigator channels. Med Phys 37(3):1017-28, 2010. e-Pub 2010. PMID: 20384237.
Milot L, Guindi M, Gallinger S, Moulton CA, Brock KK, Dawson LA, Haider MA. MR imaging correlates of intratumoral tissue types within colorectal liver metastases: a high-spatial-resolution fresh ex vivo radiologic-pathologic correlation study. Radiology 254(3):747-54, 2010. e-Pub 2010. PMID: 20123902.
Brock KK, Accuracy Consortium DR. Results of a multi-institution deformable registration accuracy study (MIDRAS). Int J Radiat Oncol Biol Phys 76(2):583-96, 2010. e-Pub 2010. PMID: 19910137.
Yaffe MJ, Boone JM, Packard N, Alonzo-Proulx O, Huang SY, Peressotti CL, Al-Mayah A, Brock K. The myth of the 50-50 breast. Med Phys 36(12):5437-43, 2009. e-Pub 2009. PMID: 20095256.
Nithiananthan S, Brock KK, Daly MJ, Chan H, Irish JC, Siewerdsen JH. Demons deformable registration for CBCT-guided procedures in the head and neck: convergence and accuracy. Med Phys 36(10):4755-64, 2009. e-Pub 2009. PMID: 19928106.
Al-Mayah A, Moseley J, Velec M, Brock KK. Sliding characteristic and material compressibility of human lung: parametric study and verification. Med Phys 36(10):4625-33, 2009. e-Pub 2009. PMID: 19928094.
Case RB, Sonke JJ, Moseley DJ, Kim J, Brock KK, Dawson LA. Inter- and intrafraction variability in liver position in non-breath-hold stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 75(1):302-8, 2009. e-Pub 2009. PMID: 19628342.
Lim K, Kelly V, Stewart J, Xie J, Cho YB, Moseley J, Brock K, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cancer of the cervix: is what you plan actually what you deliver?. Int J Radiat Oncol Biol Phys 74(1):304-12, 2009. e-Pub 2009. PMID: 19362250.
Nguyen TN, Moseley JL, Dawson LA, Jaffray DA, KK B. Adapting liver motion models using a navigator channel technique. Med Phys 36(4):1061-73, 2009. e-Pub 2009. PMID: 19472611.
White EA, Brock KK, Jaffray DA, Catton CN. Inter-observer variability of prostate delineation on cone beam computerised tomography images. Clin Oncol (R Coll Radiol) 21(1):32-8, 2009. e-Pub 2009. PMID: 19058954.
Al-Mayah A, Moseley M, Chau L, Breen S, Brock K. Biomechanical based deformable image registration of head and neck for radiation therapy. SPIE Proceedings Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 2009. e-Pub 2009.
Nithiananthan S, Brock KK, Daly MJ, Chan H, Irish JC, Siewerdsen JH. Demons deformable registration for cone-beam CT guidance: registration of pre and intraoperative images in the presence of excised tissue. SPIE Proceedings Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 2009. e-Pub 2009.
Al-Mayah A, Moseley J, Velec M, Brock K. Effect of heterogeneous material of the lung on deformable image registration. SPIE Proceedings: Visualization, Image-Guided Procedures, and Modeling 7261, 2009. e-Pub 2009.
Vesprini D, Ung Y, Dinniwell R, Breen S, Cheung F, Grabarz D, Kamra J, Mah K, Mansouri A, Pond G, Brock K, Darling G, Knox J, Haider M, Wong RK. Improving observer variability in target delineation for gastro-oesophageal cancer--the role of (18F)fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography. Clin Oncol (R Coll Radiol) 20(8):631-8, 2008. e-Pub 2008. PMID: 18755578.
Brock KK, Nichol AM, Ménard C, Moseley JL, Warde PR, Catton CN, Jaffray DA. Accuracy and sensitivity of finite element model-based deformable registration of the prostate. Med Phys 35(9):4019-25, 2008. e-Pub 2008. PMID: 18841853.
Kirilova A, Lockwood G, Choi P, Bana N, Haider MA, Brock KK, Eccles C, Dawson LA. Three-dimensional motion of liver tumors using cine-magnetic resonance imaging. Int J Radiat Oncol Biol Phys 71(4):1189-95, 2008. e-Pub 2008. PMID: 18258378.
Al-Mayah A, Moseley J, Brock KK. Contact surface and material nonlinearity modeling of human lungs. Phys Med Biol 53(1):305-17, 2008. e-Pub 2008. PMID: 18182705.
Sharpe M, Brock KK. Quality assurance of serial 3D image registration, fusion, and segmentation. Int J Radiat Oncol Biol Phys 71(1 Suppl):S33-7, 2008. e-Pub 2008. PMID: 18406934.
Nguyen TN, Moseley JL, Dawson LA, Jaffray DA, Brock KK. Adapting population liver motion models for individualized online image-guided therapy. Conf Proc IEEE Eng Med Biol Soc 2008:3945-8, 2008. e-Pub 2008. PMID: 19163576.
Nithiananthan S, Brock KK, Irish JC, Siewerdsen JH. Deformable registration for intra-operative cone-beam CT guidance of head and neck surgery. Conf Proc IEEE Eng Med Biol Soc 2008:3634-7, 2008. e-Pub 2008. PMID: 19163498.
Brock KK, Hawkins M, Eccles C, Moseley JL, Moseley DJ, Jaffray DA, Dawson LA. Improving image-guided target localization through deformable registration. Acta Oncol 47(7):1279-85, 2008. e-Pub 2008. PMID: 18766475.
Wiltshire KL, Brock KK, Haider MA, Zwahlen D, Kong V, Chan E, Moseley J, Bayley A, Catton C, Chung PW, Gospodarowicz M, Milosevic M, Kneebone A, Warde P, Ménard C. Anatomic boundaries of the clinical target volume (prostate bed) after radical prostatectomy. Int J Radiat Oncol Biol Phys 69(4):1090-9, 2007. e-Pub 2007. PMID: 17967303.
Hensel JM, Ménard C, Chung PW, Milosevic MF, Kirilova A, Moseley JL, Haider MA, Brock KK. Development of multiorgan finite element-based prostate deformation model enabling registration of endorectal coil magnetic resonance imaging for radiotherapy planning. Int J Radiat Oncol Biol Phys 68(5):1522-8, 2007. e-Pub 2007. PMID: 17674983.
Martel AL, Froh MS, Brock KK, Plewes DB, Barber DC. Evaluating an optical-flow-based registration algorithm for contrast-enhanced magnetic resonance imaging of the breast. Phys Med Biol 52(13):3803-16, 2007. e-Pub 2007. PMID: 17664578.
Breen SL, Publicover J, De Silva S, Pond G, Brock K, O'Sullivan B, Cummings B, Dawson L, Keller A, Kim J, Ringash J, Yu E, Hendler A, Waldron J. Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers. Int J Radiat Oncol Biol Phys 68(3):763-70, 2007. e-Pub 2007. PMID: 17379435.
Kaus MR, Brock KK, Pekar V, Dawson LA, Nichol AM, Jaffray DA. Assessment of a model-based deformable image registration approach for radiation therapy planning. Int J Radiat Oncol Biol Phys 68(2):572-80, 2007. e-Pub 2007. PMID: 17498570.
Nichol AM, Brock KK, Lockwood GA, Moseley DJ, Rosewall T, Warde PR, Catton CN, Jaffray DA. A magnetic resonance imaging study of prostate deformation relative to implanted gold fiducial markers. Int J Radiat Oncol Biol Phys 67(1):48-56, 2007. e-Pub 2007. PMID: 17084546.
Voroney JP, Brock KK, Eccles C, Haider M, Dawson LA. Prospective comparison of computed tomography and magnetic resonance imaging for liver cancer delineation using deformable image registration. Int J Radiat Oncol Biol Phys 66(3):780-91, 2006. e-Pub 2006. PMID: 17011453.
Hawkins MA, Brock KK, Eccles C, Moseley D, Jaffray D, Dawson LA. Assessment of residual error in liver position using kV cone-beam computed tomography for liver cancer high-precision radiation therapy. Int J Radiat Oncol Biol Phys 66(2):610-9, 2006. e-Pub 2006. PMID: 16966004.
Eccles C, Brock KK, Bissonnette JP, Hawkins M, Dawson LA. Reproducibility of liver position using active breathing coordinator for liver cancer radiotherapy. Int J Radiat Oncol Biol Phys 64(3):751-9, 2006. e-Pub 2006. PMID: 16458774.
Brock KK, Dawson LA, Sharpe MB, Moseley DJ, Jaffray DA. Feasibility of a novel deformable image registration technique to facilitate classification, targeting, and monitoring of tumor and normal tissue. Int J Radiat Oncol Biol Phys 64(4):1245-54, 2006. e-Pub 2006. PMID: 16442239.
Froh MS, Barber DC, Brock KK, Plewes DB, Martel AL. Piecewise-quadrilateral registration by optical flow--applications in contrast-enhanced MR imaging of the breast. Med Image Comput Comput Assist Interv 9(Pt 2):686-93, 2006. e-Pub 2006. PMID: 17354832.
Brock KK, Menard C, Hensel J, Jaffray DA. A multi-organ biomechanical model to analyze prostate deformation due to large deformation of the rectum. SPIE Proceedings: Physiology, Function, and Structure from Medical Images 6143, 2006. e-Pub 2006.
Balter JM, Brock KK, Lam KL, Tatro D, Dawson LA, McShan DL, Ten Haken RK. Evaluating the influence of setup uncertainties on treatment planning for focal liver tumors. Int J Radiat Oncol Biol Phys 63(2):610-4, 2005. e-Pub 2005. PMID: 16095848.
Dawson LA, Eccles C, Bissonnette JP, Brock KK. Accuracy of daily image guidance for hypofractionated liver radiotherapy with active breathing control. Int J Radiat Oncol Biol Phys 62(4):1247-52, 2005. e-Pub 2005. PMID: 15990028.
Brock KK, Sharpe MB, Dawson LA, Kim SM, Jaffray DA. Accuracy of finite element model-based multi-organ deformable image registration. Med Phys 32(6):1647-59, 2005. e-Pub 2005. PMID: 16013724.
Park H, Bland PH, Brock KK, Meyer CR. Adaptive registration using local information measures. Med Image Anal 8(4):465-73, 2004. e-Pub 2004. PMID: 15567709.
Brock KM, Balter JM, Dawson LA, Kessler ML, Meyer CR. Automated generation of a four-dimensional model of the liver using warping and mutual information. Med Phys 30(6):1128-33, 2003. e-Pub 2003. PMID: 12852537.
Brock KK, McShan DL, Ten Haken RK, Hollister SJ, Dawson LA, Balter JM. Inclusion of organ deformation in dose calculations. Med Phys 30(3):290-5, 2003. e-Pub 2003. PMID: 12674227.
Brock KK, Hollister SJ, Dawson LA, Balter JM. Technical note: creating a four-dimensional model of the liver using finite element analysis. Med Phys 29(7):1403-5, 2002. e-Pub 2002. PMID: 12148719.
Litzenberg D, Dawson LA, Sandler H, Sanda MG, McShan DL, Ten Haken RK, Lam KL, Brock KK, Balter JM. Daily prostate targeting using implanted radiopaque markers. Int J Radiat Oncol Biol Phys 52(3):699-703, 2002. e-Pub 2002. PMID: 11849792.
Balter JM, Brock KK, Litzenberg DW, McShan DL, Lawrence TS, Ten Haken R, McGinn CJ, Lam KL, Dawson LA. Daily targeting of intrahepatic tumors for radiotherapy. Int J Radiat Oncol Biol Phys 52(1):266-71, 2002. e-Pub 2002. PMID: 11777645.
Brock KK, McShan DL, Balter JM. A comparison of computer-controlled versus manual on-line patient setup adjustment. J Appl Clin Med Phys 3(3):241-7, 2002. e-Pub 2002. PMID: 12132947.
Dawson LA, Brock KK, Kazanjian S, Fitch D, McGinn CJ, Lawrence TS, Ten Haken RK, Balter J. The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy. Int J Radiat Oncol Biol Phys 51(5):1410-21, 2001. e-Pub 2001. PMID: 11728702.
Balter JM, Dawson LA, Kazanjian S, McGinn C, Brock KK, Lawrence T, Ten Haken R. Determination of ventilatory liver movement via radiographic evaluation of diaphragm position. Int J Radiat Oncol Biol Phys 51(1):267-70, 2001. e-Pub 2001. PMID: 11516877.
Dawson LA, Litzenberg DW, Brock KK, Sanda M, Sullivan M, Sandler HM, Balter JM. A comparison of ventilatory prostate movement in four treatment positions. Int J Radiat Oncol Biol Phys 48(2):319-23, 2000. e-Pub 2000. PMID: 10974443.

Review Articles

Bosma LS, Hussein M, Jameson MG, Asghar S, Brock KK, McClelland JR, Poeta S, Yuen J, Zachiu C, Yeo AU. Tools and recommendations for commissioning and quality assurance of deformable image registration in radiotherapy. Phys Imaging Radiat Oncol 32:100647, 2024. e-Pub 2024. PMID: 39328928.
Sheth RA, Wehrenberg-Klee E, Patel SP, Brock KK, Fotiadis N, de Baère T. Intratumoral Injection of Immunotherapeutics: State of the Art and Future Directions. Radiology 312(1):e232654, 2024. e-Pub 2024. PMID: 39078294.
Brock KK, Chen SR, Sheth RA, Siewerdsen JH. Imaging in Interventional Radiology: 2043 and Beyond. Radiology 308(1):e230146, 2023. e-Pub 2023. PMID: 37462500.
Murr M, Brock KK, Fusella M, Hardcastle N, Hussein M, Jameson MG, Wahlstedt I, Yuen J, McClelland JR, Vasquez Osorio E. Applicability and usage of dose mapping/accumulation in radiotherapy. Radiother Oncol 182:109527, 2023. e-Pub 2023. PMID: 36773825.
Baroudi H, Brock KK, Cao W, Chen X, Chung C, Court LE, El Basha MD, Farhat M, Gay S, Gronberg MP, Gupta AC, Hernandez S, Huang K, Jaffray DA, Lim R, Marquez B, Nealon K, Netherton TJ, Nguyen CM, Reber B, Rhee DJ, Salazar RM, Shanker MD, Sjogreen C, Woodland M, Yang J, Yu C, Zhao Y. Automated Contouring and Planning in Radiation Therapy: What Is 'Clinically Acceptable'?. Diagnostics (Basel) 13(4), 2023. e-Pub 2023. PMID: 36832155.
Singh BS, Cazacu IM, Deza CA, Rigaud BS, Saftoiu A, Gruionu G, Guionu L, Brock KK, Koay EJ, Herman JM, Bhutani MS. Image Fusion Involving Real-Time Transabdominal or Endoscopic Ultrasound for Gastrointestinal Malignancies: Review of Current and Future Applications. Diagnostics (Basel) 12(12), 2022. e-Pub 2022. PMID: 36553225.
McDonald BA, Zachiu C, Christodouleas J, Naser MA, Ruschin M, Sonke JJ, Thorwarth D, Létourneau D, Tyagi N, Tadic T, Yang J, Li XA, Bernchou U, Hyer DE, Snyder JE, Bubula-Rehm E, Fuller CD, Brock KK. Dose accumulation for MR-guided adaptive radiotherapy: From practical considerations to state-of-the-art clinical implementation. Front Oncol 12:1086258, 2022. e-Pub 2022. PMID: 36776378.
Sen A, Troncoso P, Venkatesan A, Pagel MD, Nijkamp JA, He Y, Lesage AC, Woodland M, Brock KK. Correlation of in-vivo imaging with histopathology: A review. Eur J Radiol 144:109964, 2021. e-Pub 2021. PMID: 34619617.
Lin YM, Paolucci I, Brock KK, Odisio BC. Image-Guided Ablation for Colorectal Liver Metastasis: Principles, Current Evidence, and the Path Forward. Cancers (Basel) 13(16), 2021. e-Pub 2021. PMID: 34439081.
Jacobsen MC, Thrower SL, Ger RB, Leng S, Court LE, Brock KK, Tamm EP, Cressman ENK, Cody DD, Layman RR. Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement. Med Phys 47(8):3752-3771, 2020. e-Pub 2020. PMID: 32453879.
Cardenas CE, Yang J, Anderson BM, Court LE, KK B. Advances in Auto-Segmentation. Semin Radiat Oncol 29(3):185-197, 2019. e-Pub 2019. PMID: 31027636.
Brock KK. Imaging and image-guided radiation therapy in liver cancer. Semin Radiat Oncol 21(4):247-55, 2011. e-Pub 2011. PMID: 21939853.
Meyer JL, Sharpe M, Brock K, Deasy J, Craig T, Moseley D, Alaly J, Zakaryan K. Advanced technologies in the radiotherapy clinic: system fundamentals. Front Radiat Ther Oncol 43:29-59, 2011. e-Pub 2011. PMID: 21625147.
Brock KK, Dawson LA. Adaptive management of liver cancer radiotherapy. Semin Radiat Oncol 20(2):107-15, 2010. e-Pub 2010. PMID: 20219548.
Jaffray DA, Lindsay PE, Brock KK, Deasy JO, Tomé WA. Accurate accumulation of dose for improved understanding of radiation effects in normal tissue. Int J Radiat Oncol Biol Phys 76(3 Suppl):S135-9, 2010. e-Pub 2010. PMID: 20171508.
Brock, KK KK. Image registration in intensity- modulated, image-guided and stereotactic body radiation therapy. Front Radiat Ther Oncol 40:94-115, 2007. e-Pub 2007. PMID: 17641504.

Abstracts

Cazoulat G, Kipritidis J, Siva S, Hofman M, Jolly S, Matuszak M, Balter J, Keall P, Brock KK. WE‐AB‐202‐05: Validation of Lung Stress Maps for CT‐Ventilation Imaging. Medical Physics 43(6Part38), 2016. e-Pub 2016.
Cazoulat G, Owen D, Matuszak M, Balter J, Brock KK. SU‐E‐J‐91: Biomechanical Deformable Image Registration of Longitudinal Lung CT Images. Medical Physics 42(6 Part8), 2015. e-Pub 2015.
Hunter SF, Al-Mayah A, Moseley J, Bezjak A, Brock KK. Impact of breathing motion and uncertainities on the accumulated dose in lung SBRT. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 81(Suppl 2):S86-S87, 2011. e-Pub 2011.
Ng A, Hodgson DC, Moseley JL, Sharpe MB, Nguyen TN, San Miguel J, Brock KK. Three dimensional normal tissue dose reconstruction of historical hodgkin's lymphoma patients for correlation with late toxicity. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 81(Suppl 2):S798, 2011. e-Pub 2011.
Velec M, Moseley JL, Dawson LA, Brock KK. Impact and implementation guidelines for liver SBRT delivery with deformable registration and dose accumulation. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 81(Suppl 2):S766-S767, 2011. e-Pub 2011.
Swaminath A, Jacks L, Massey C, Kim J, Dinniwell R, Brierley J, Wong R, Velec M, Brock KK, Dawson LA. Accumulated delivered dose-response of stereotactic body radiotherapy (SBRT) for liver metastases. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 81(Suppl 2):S347, 2011. e-Pub 2011.
Samavati N, McGrath D, Lee J, Van der Kwast T, Menard C, Brock K. Optimization of a deformable registration algorithm for matching MRI with histology for clinical prostatectomy. AAPM annual meeting. Medical Physics 38(6):3761, 2011. e-Pub 2011.
Swaminath A, Knox JJ, Brierly JD, Dinniwell R, Wong R, Kassam Z, Kim JJ, Brock KK. Changes in liver volume during radiotherapy delivered concurrently with sorafenib. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 78(Suppl 3):S24, 2010. e-Pub 2010.
Moseley JL, Hunter SF, Al-Mayah A, Brock KK. Evaluation of lung hysteresis using a bifurcation tracking code and deformable image registration. ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 78(Suppl 3):S43, 2010. e-Pub 2010.
Velec M, Moseley J, Dawson LA, Brock KK. Effect of dose gardients on accumulated dose in liver stereotactic-body radiotherapy (SBRT). ASTRO annual meeting. International Journal of Radiation Oncology, Biology, Physics 78(Suppl 3):S692, 2010. e-Pub 2010.
Nguyen TN, Moseley JL, Dawson LA, Brock KK. Breathing motion and deformation of pancreatic cancer patients and its effect on planning dose. Medical Physics 37(6):3459, 2010. e-Pub 2010.
Kelly V, Xie J, Kim K, Brock K, Lundin A, Rehbinder H, Fyles A, Jaffray D, Milosevic M, Cho Y. Planning target volumes for cervix cancer radiotherapy using a modified convex hull technique. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S380, 2009. e-Pub 2009.
Rit S, Nguyen T, van Herk M, Brock K, Sonke S. On-the-fly motion-compensated cone-beam CT using a motion model updated via navigator channels. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S22, 2009. e-Pub 2009.
Stewart J, Lim K, Brock, Moseley J, Xie J, Lundin A, Rehbinder H, Fyles A, Jaffray D, Milosevic M. Optimized replanning for IMRT of cervix cancer based on dosimetric assessment of treatment progress. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S85, 2009. e-Pub 2009.
Ng A, Nguyen TN, Moseley J, Hodgson D, Sharpe M, Brock KK. Feasibility of a navigator channel bilinear adaptation technique to generate 3D heart volumes from 2D Hodgkin lymphoma planning data. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S617, 2009. e-Pub 2009.
Hunter SF, Al-Mayah A, Moseley J, Bezjak A, Brock KK. Effect of breathing motion on dose accumulation in the lung bronchial tree. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S26, 2009. e-Pub 2009.
Chau L, Allaire S, Brock KK, Pekar V, Waldron JN, Breen SL. Validation of an automated segmentation method for head and neck adaptive radiotherapy using cone-beam computed tomography (CBCT). International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S143, 2009. e-Pub 2009.
Velec M, Moseley J, Dawson LA, Brock KK. Importance of deformation, including baseline shifts and breathing variation, on dose accumulation in liver SBRT. International Journal of Radiation Oncology, Biology, Physics 75(Suppl 3):S25-S26, 2009. e-Pub 2009.
Vlad R, Kolios M, Moseley J, Czarnota G, Brock K. Evaluating extent of cell death in 3D mid-to-high frequency ultrasound by registration with whole-mount tumor histopathology 36(6):2760-2761, 2009. e-Pub 2009.
Nguyen TN, Moseley J, Dawson L, Jaffray D, Brock K. Motion adaptation for registering daily online CBCT images to planning CT images. Medical Physics 36(6):2456, 2009. e-Pub 2009.
McNiven A, Moseley J, Langer DL, Haider MA, Brock KK. Preliminary feasibility study: Modeling 3D deformations of the prostate from whole-mount histology to in vivo MRI. Medical Physics 36(6):2712-2713, 2009. e-Pub 2009.
Ng A, Moseley J, Nguyen TN, Hodgson D, Sharpe M, Brock K. A novel technique to generate 3D lung volumes from 2D hodgkin lymphoma planning datasets using combined deformable image registration and navigator channels. Medical Physics 36(6):2470, 2009. e-Pub 2009.
Nighiananthan S, Brock KK, Irish JC, Siewerdsen JH. Demons deformable registration for cone-beam CT-guided procedures in the head and neck: Multi-scale implementation, optimization, and characterization. CARS (Computer-Assisted Radiology and Surgery) Annual Meeting, Berlin Germany, 2009. e-Pub 2009.
Cho Y, Xie J, Kelly V, Lim K, Stewart J, Fyles A, Brock K, Lundin A, Rehbinder H, Milosevic M. Region of interest analysis as a tool for exploring adaptive IMRT strategy for cervix cancer patients. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):$585-S586, 2008. e-Pub 2008.
Magierowski K, Moseley J, Lockwood G, Parent A, Euler C, Sharpe M, Griffin A, Brock K, Catton C, O'Sullivan B. Retrospctive study of volume changes in tow pathological subtypes of sarcomas using deformation image registration. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S504, 2008. e-Pub 2008.
Craig T, Satkusagingham J, Chan K, Brock KK, Moseley J, Chung P, Bayley A, Crook J, Jaffray D, Menard C. Advanced image guidance allows margin reduction in radiation therapy of prostate cancer. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S551, 2008. e-Pub 2008.
Lim KSH, Kelly V, Stewart J, Moseley J, Brock K, Cho Y, Fyles A, Lundin A, Rehbinder H, Milosevic M. Whole pelvis IMRT for cervix cancer: what gets missed and why?. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S112, 2008. e-Pub 2008.
Velec M, Moseley J, Dawson LA, Brock KK. Accumulated treatment dose for image guided liver radiotherapy using deformable registration of 4D cone beam CT. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S149, 2008. e-Pub 2008.
Stewart JMP, Lim K, Brock KK, Moseley JL, Xie J, Lundin A, Rehbinder H, Fyles A, Milosevic M, Jaffray DA. Automated weekly online replanning for IMRT of cervix cancer. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S18, 2008. e-Pub 2008.
Brock KK, Lee M, Ecles CL, Velec M, Moseley JL, Dawson LA. Deformable registration and dose accumulation to investigate marginal liver cancer recurrences. International Journal of Radiation Oncology, Biology, Physics 72(Suppl 1):S538, 2008. e-Pub 2008.
Al-Mayah A, Moseley JL, Velec M, Brock KK. Effect of friction and material compressibility on deformable modeling of human lung. Proceedings of the 4th International Symposium on Biomedical Simulation:98-106, 2008. e-Pub 2008.
Brock K. Imaging for planning/verification: In-room imaging. Medical Physics 35(6):2925-2926, 2008. e-Pub 2008.
Cho Y, Kelly V, Lim K, Stewart J, Fyles A, Brock K, Moseley J, Xie J, Lundin A, Rehbiner H, Milosevic M. Planning target volume adaptation using convex hull of CTVs for cervix cancer patients. Medical Physics 35(6):2739, 2008. e-Pub 2008.
Lee MT, Brock KK, Dawson LA. Multimodality image-guided radiotherapy of the liver 12(1):32-41, 2008. e-Pub 2008.
Zhang B, MacFadden D, Damyanovich AZ, Rieker M, Brock KK, Hodaie M, Laperriere N, Schwartz M, Tsao M, Stainsby J, Jaffray DA Bernstein M, Mikulis D, Menard C. Phantom and clinical validation of 3t MRI for gamma knife radiosurgery treatment planning. Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, 2008. e-Pub 2008.
Eccles CL, Brock KK, Moseley J, Moseley D, Jaffray D, Dawson LA. Variability in liver shape and impact on GTV position during liver stereotactic radiotherapy with abdominal compression. Int J Radiat Oncol Biol Phys 69(Suppl 3):S186, 2007. e-Pub 2007.
Lim K, Fyles A, Lundin A, Cho Y, Kelly V, Moseley J, Brock K, Stewart J, Rehbinder H, Milosevic M. Adaptive whole pelvis intensity modulated radiotherapy for cervix cancer. International Journal of Radiation Oncolology Biololgy Physics 69(Suppl 3):S385-S386, 2007. e-Pub 2007.
Dawson LA, Brock KK, Moulton C, Moseley J, Ahmed S, Guindi M, Gallinger S, Haider M. Comparison of liver metastases volumes on CT, MR and FDG PET imaging to pathological resection using deformable image registration. Int J Radiat Oncol Biol Phys 69(Suppl 3):S68, 2007. e-Pub 2007.
Brock KK. A multi-institution deformable registration accuracy study on behalf of the deformable registration accuracy consortium. International Journal of Radiation Oncology, Biology, Physics 69(Suppl 3):S44, 2007. e-Pub 2007.
Rehbinder H, Lundin A, Cho Y, Lim K, Brock K, Fyles A, Kelly V, Milosevic M, Moseley J, Stewart J, Xie J, Chan P, Jaffray D. Impact of organ motion on IMRT dose distributions for patients with cancer of the cervix. Medical Physics 34(6):2647-2648, 2007. e-Pub 2007.
Nguyen TN, Moseley JL, Dawson LA, Jaffray DA, Brock KK. Generating patient specific motion models using a navigator channel and liver population fem motion model. Medical Physics 34(6):2515-2516, 2007. e-Pub 2007.
Brock KK, Moseley J, Eccles C, Craig T, Sharpe MB, Dawson LA. Effect of deformation due to breathing on dose accumulation for liver cancer radiotherapy. Int J Radiat Oncol Biol Phys 66(Suppl 3):S52, 2006. e-Pub 2006.
De Silva SL, Waldron JN, Breen S, Brock K, Pond G, Cummings B, Dawson L, Kim J, Rngash J, O'Sullivan B. Multiobserver vaiability in abnormal lymph node identification with FDG-PET and contrast enhanced CT in head and neck cancer: qualitative analysis and potential clinical significance. Int J Radiat Oncol Biol Phys 66(Suppl 3):S439-S440, 2006. e-Pub 2006.
Vesprini D, Ung Y, Kamra J, Dinniwell R, Grabarz D, Pond G, Breen S, Cheung F, Haider M, Mah K, Brock K, Wong R. The impact of 18-fluorodeozyglucose positron emission tomography (FDG-PET) on radiotherapy planning in carcinoma of the esophagus. Radiotherapy & Oncology 80(Suppl 1):S21, 2006. e-Pub 2006.
Brock K, Hawkins M, Eccles C, Moseley J, Moseley D, Dawson L. Improving image-guided target localization through deformable registration. Radiotherapy & Oncology 80(Suppl 1):S18, 2006. e-Pub 2006.
Brock K, Moseley D, Jaffray D. Quantification of patient specific target motion in the presence of limited data through population models. Medical Physics 33(6):2046, 2006. e-Pub 2006.
Brock K, Ahmed S, Moseley J, Moulton C, Guind M, Haider M, Gallinger S, Dawson L. Deformable registration for in vivo imaging and pathology correlation. Medical Physics 33(6):1994, 2006. e-Pub 2006.
Brock K, Dawson L, Sharpe M, Moseley D, Moseley J, Craig T, Jaffray D. Deformable registration and modeling for precision application and assessment of stereotactic body radiotherapy. Radiotherapy & Oncology 78(Suppl 1):S59, 2006. e-Pub 2006.
Hensel J, Menard C, Kirilova A, Chung P, Brock K. Development of a prostate deformation model to enable accurate registration of endorectal coil magnetic resonance images (ERC-MRI). Radiotherapy & Oncology 78(Suppl 1):S69, 2006. e-Pub 2006.
Hawkins MA, Brock K, Eccles C, Moseley D, Jaffray D, Dawson LA. Breath hold cone beam CT for image guided sterotactic radiotherapy for liver cancer. Radiotherapy & Oncology 78(Suppl 1):S80, 2006. e-Pub 2006.
Brock K, Ahmed S, Moseley J, Moulton C, Guindi M, Haider M, Gallinger S, Dawson L. Deformable registration for in vivo imaging and pathology correlation 33(6):1994, 2006. e-Pub 2006.
Wiltshire K, Brock K, Haider M, Warde P, Chung P, Gaspodarowicz M, Catton C, Bayley A, Milosevic M, Menard C. Achieving a consensus definition for anatomic boundaries of the ctv (prostate bed): methods and observer reproducibility using MRI. International Journal of Radiation Oncology, Biology, Physics 66(3):S208, 2006. e-Pub 2006.
E-S K, Menard C, B-A M, Kassner A, Damyanovich A, Brock K, Keller A, Yu E, Hoisak J, Kirilova A, Laperriere N. Early changes for monitoring therapeutic response during chemotherapy and radiotherapy for glioblastoma multiforme. Radiotherapy and Oncology 81(Suppl 1):S293-4, 2006. e-Pub 2006.
Verprini D, Ung Y, Kamra J, Dinniwell R, Grabarz D, Breen S, Pond G, Brock K, Wong RKS. The addition of 18-flourodeoxyglucose positron emission tomography (FDG-PET) to CT based radiotherapy planning of carcinoma of the esophagus decreases both the intra- and interobserver variability of GTV delineation. International Journal of Radiation Oncology, Biology, Physics 66(3):S299-S300, 2006. e-Pub 2006.
Rehbinder H, Lundin A, Sharpe M, Brock KK, Dawson LA, O'Sullivan B, Kaus MR, Jaffray DA. Can PTV margins for head and neck cancer be reduced on a single adaptive replanning event?. International Journal of Radiation Oncology, Biology, Physics 66(3):S101, 2006. e-Pub 2006.
Brock K, Moseley J, Jaffray D. A novel metric for automatic assessment of deformable image registration accuracy. Medical Physics 32(6):1942, 2005. e-Pub 2005.
Brock K, Moseley J, Stewart J, Lim K, Xie J, Lundin A Rehbinder H, Fyles A Milosevic M, Jaffray D. Image guided radiotherapy of the cervix with biomechanical model-based deformable registration. Medical Physics 35(6):2702, 2005. e-Pub 2005.
Dawson L, Voroney J, Eccles C, Haider M, Brock K. Spatial and volumetric comparison of liver tumors on ct and mr using finite element based deformable image registration. Medical Physics 32(6):1894-5, 2005. e-Pub 2005.
Hoisak J, Zheng J, Perkins G, Brock K, Allen C, Jaffray D. Mutual information as a metric of multimodality contrast agent efficacy. Medical Physics 32(6):1943, 2005. e-Pub 2005.
Kim A, Jaffray D, Brock K. The effect of heterogeneous and nonlinear material properties on organ deformation. Medical Physics 32(6):2143, 2005. e-Pub 2005.
DeSilva S, Waldron J, Breen S, Brock K, Pond G, Bayley A, Cummings B, Dawson L, Keller H, Kim J, Ringash J, Yu E, Hendler A, O'Sullivan B. Radiation target volume delineation (TVD) using FDG-PET and contrast enhanced CT (CECT) for patients with head and neck cancer. Radiotherapy and Oncology 76(Suppl 1):S18, 2005. e-Pub 2005.
DeSilva S, Waldron J, Breen S, Brock K, Pond G, Cummings B, Dawson L, Keller A, Kim J, Ringash J, Yu E, O'Sullivan B. Analysis of gross target volume (GTV) observer variability with FDG-PET and contrast enhanced CT in head and neck cancer using finite element modeling. International Journal of Radiation Oncology, Biology, Phyiscs 63(Suppl 1):S363-4, 2005. e-Pub 2005.
Brock KK. MR-based simulation in radiotherapy: improving tumor definition, characterizing motion, and monitoring response. Radiotherapy and Oncology 76(Suppl 2):S3, 2005. e-Pub 2005.
Eccles C, Hawkins M, J-P B, Moseley D, Brock K, Dawson L. MV, kV, and 3D image guidance for high precisiion liver cancer radiotherapy. Radiotherapy and Oncology 76(Suppl 1):S31, 2005. e-Pub 2005.
Brock K, Studer G, O'Sullivan B, Sharpe M, Jaffray D. 3D Spatial analysis of normal tissue response to irradiation of the head and neck using finite element modeling. Radiotherapy and Oncology 76(Suppl 1):S30, 2005. e-Pub 2005.
Brock KK, Dawson LA, Hawkins M, Sharpe MB, Moseley J, Jaffray DA. Imaging response assessment using finite element model-based deformable image registration: application to liver disease. International Journal of Radiation Oncology, Biology, Physics 63(Suppl 1):S140-S141, 2005. e-Pub 2005.
Brock K, Moseley J, Moseley D, Jaffray D. A ray-driven approach to generate a deformed image for image-guided radiotherapy. Radiotherapy and Oncology 76(Suppl 2):S129-S130, 2005. e-Pub 2005.
Voroney JJ, Brock KK, Eccles C, Haider M, Dawson L. A prospective comparison study of liver tumour target definition based on triphasic CT gadolinium MR. International Journal of Radiation Oncology, Biology, Physics 63(Suppl 1):S282, 2005. e-Pub 2005.
Sharpe MB, Brock KK, Rehbinder H, Forsgren C, Lundin A, Dawson LA, Studer G, O'Sullivan B, McNutt TR, Kaus MR, Lof J, Jaffray DA. Adaptive planning and delivery to account for anatomical changes induced by radiation therapy of head and neck cancer. International Journal of Radiation Oncology, Biology, Physics 63(Suppl 1):S3, 2005. e-Pub 2005.
Brock KK, Sharpe MB, Jaffray DA. Biomechanical modeling of anatomical deformation for image-guided registration of soft-tissue surrogates, 2004. e-Pub 2004.
Dawson L, Eccles C, Kirilova A, Brock K. Three dimensional motion of liver tumours using cine MRI compared to liver motion assessed at fluoroscopy. Radiotherapy and Oncology 73(Suppl 1):S214, 2004. e-Pub 2004.
Brock KK, Dawson LA, Sharpe MB, Jaffray DA. Application of a novel deformable image registration technique to facilitate classification, tracking and targeting of tumor and normal tissue. International Journal of Radiation Oncology, Biology, Physics 60(Suppl 1):S227, 2004. e-Pub 2004.
Dawson LA, Eccles C, Brock KK, Bissonnette J. Accuracy of image guidance for stereotactic liver radiotherapy using active breathing control and daily soft tissue imaging. International Journal of Radiation Oncology, Biology, Physics 60(Suppl 1):S334-5, 2004. e-Pub 2004.
Nichol A, Brock K, Moseley D, Catton C, Warde P, Jaffray D. A magnetic resonance imaging study of prostate deformation relative to implanted gold fiducial markers. Radiotherapy and Oncology 73(Suppl 1):S402, 2004. e-Pub 2004.
Eccles C, Brock K, Bissonnette JP, Dawson LA. Reproducibility of liver position using active breathing control for liver cancer radiotherapy. Radiotherapy and Oncology 72(Suppl1):S5, 2004. e-Pub 2004.
Brock KK, McGibney CA, Vallis KA, Alasti H, Jaffray DA. Registration of multi-modality imaging for precision radiation therapy of the breast. Radiotherapy and Oncology 72(Suppl1):S57, 2004. e-Pub 2004.
Jaffray D, Brock K, Nichol A, Moseley D, Catton C, Warde P. An analysis of inter-fraction prostate deformation relative to implanted fiducial markers using finite element modeling. International Journal of Radiation Oncology, Biology, Physics 60(Suppl 1):S229, 2004. e-Pub 2004.
ELin, Chintalapani G, Brock K, Avritscher R, Odisio B. Intra-arterial CT hepatic angiography for tumor detection and ablation endpoint assessment: a proof-of-concept analysis.

Book Chapters

Brock KK. IGRT for liver malignancies. In: Image-guided Adaptive Radiation Therapy in Clinical Practice. 1, 2013.
Al-Mayah A, Brock KK. Toward efficient biomechanical-based deformable image registration of lungs for image-guided radiotherapy. In: Image Processing in Radiation Therapy. Taylor and Francis Group, LLC, 85-94, 2013.
Brock KK, Velec M, Lee JHM. Validation of Image Registration. In: Image Processing in Radiation Therapy. Taylor and Francis Group, LLC, 41-64, 2013.
Brock KK, Al-Mayah A, Velec M. American Association of Physicists in Medicine Summer School Proceedings, Madison, Wisconsin. In: Uncertainties in Deformable Registration. Uncertainties in external beam radiation therapy, 403-442, 2011.
Lim K, Milosevic M, Brock KK, Fyles A. Image-Guidance in External Beam Planning for Locally Advanced Cervical Cancer. In: Gynecologic Radiation Therapy. Springer, 2011.
Sharpe M, Brock KK. Quality Assurance of Serial 3D Image Registration, Fusion, and Segmentation. In: International Journal of Radiation Oncology• Biology• Physics. Elsevier, S33-S37, 2008.
Kaus, MR, Brock, KK. Deformable Image Registration for Radiation Therapy Planning: Algorithms and Applications. In: Biomechanical Systems Technology. World Science, 2007.
Brock KK. Front Radiat Ther Oncol. In: Image registration in intensity-modulated, image-guided and stereotactic body radiation therapy. Karger, 94-115, 2007.
Jaffray DA, Brock KK, and Sharpe MB. Advanced Imaging and Guidance Systems for Use in Intensity Modulated RT. In: Image-Guided IMRT. 2, 217-227, 2005.
Sharpe MB, Velec M, Brock KK. Image Registration and Segmentation in Radiation Therapy. In: Image in Medical Diagnosis and Therapy.

Books (edited and written)

Brock KK. Image Processing in Radiation Therapy. Ed(s) 1. Taylor and Francis Group, LLC, 2013.

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CV information above last modified July 30, 2025

Kristy K. Brock, Ph.D.

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Kristy K. Brock, Ph.D.

About Dr. Brock

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Research Interests

Education & Training

Degree-Granting Education

Licenses & Certifications

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Institutional Committee Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Local Presentations

Regional Presentations

National Presentations

International Presentations

Formal Peers

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Review Articles

Other Articles

Abstracts

Book Chapters

Books (edited and written)

Patient Reviews

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Related Links

Morfeus Laboratory

Image Guided Cancer Therapy Research Program

Imaging Physics Department

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