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Kyle Mitchell, MD, MSc

Department of Thoracic and Cardiovascular Surgery, Division of Surgery

About Dr. Kyle Mitchell

Kyle G. Mitchell, M.D., M.Sc., is an Assistant Professor in the Department of Thoracic and Cardiovascular Surgery. Dr. Mitchell completed his undergraduate degree in economics at the University of Notre Dame and earned his medical degree at the... University of Texas McGovern Medical School in Houston. He was subsequently the inaugural trainee in the accelerated (4+3) general surgery and cardiothoracic surgery training program at the University of Texas MD Anderson Cancer Center (MDACC) and McGovern Medical School, during which he completed a two-year dedicated research sabbatical and concurrently obtained a master's degree in clinical research methodology.

Dr. Mitchell's clinical interests are focused on complex thoracic surgical oncology and include the application of minimally invasive and organ-sparing techniques in the care of patients with early, locoregionally advanced, and oligometastatic cancers of the lung, esophagus, and mediastinum. He is trained in all aspects of thoracic surgery, including surgery for diseases of the chest wall, pleura, and airway.

Dr. Mitchell's research efforts center on the examination of immunometabolic hallmarks of tumor immunoevasion in the tumor microenvironment, the identification and validation of clinically applicable biomarkers, and the translation of the results of these investigations towards the development of novel therapeutic strategies. In addition, he is actively engaged in investigation of the rapidly evolving paradigm of local consolidation as a component of multimodality treatment strategies for patients with oligometastic NSCLC and contributed to the development of forthcoming Society of Thoracic Surgeons Clinical Practice Guidelines regarding the role of surgical therapy in this context.

Dr. Mitchell has published more than 80 peer-reviewed manuscripts to date, given numerous presentations nationally and internationally, and has received a number of awards in recognition of his clinical and academic achievements.

Primary Appointment

Assistant Professor, Department of Thoracic And Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2020	University of Texas McGovern Medical School, Houston, TX, US, Clinical Research, MSc
2015	University of Texas McGovern Medical School, Houston, TX, US, Medicine, MD
2011	University of Notre Dame, Notre Dame, IN, US, Economics, BA

Postgraduate Training

2020-2024	Resident, Joint (4+3) Cardiothoracic Surgery and General Surgery Residency (Thoracic Track), The University of Texas MD Anderson Cancer Center and University of Texas McGovern Medical School, Houston, Texas
2019-2020	Resident, General Surgery Residency, The University of Texas McGovern Medical School, Houston, Texas
2017-2019	Research Fellow, Clinical Research, The University of Texas MD Anderson Cancer Center, Houston, Texas
2017-2020	Graduate Student, Clinical Research, University of Texas McGovern Medical School, Houston, Texas
2015-2017	Resident, General Surgery, University of Texas McGovern Medical School, Houston, Texas

Experience & Service

Institutional Committee Activities

Member, Thoracic Oncology Multidisciplinary Working Group, 2024 - Present

Member, Graduate Medical Education Diversity and Disparities Subcommittee, 2022 - 2023

Member, Non-Small Cell Lung Cancer Circulome Working Group - Immunogenomic Profiling of Non-Small Cell Lung Cancer (ICON), 2021 - Present

Member, Cytokines and Angiogenic Factors Working Group- Immunogenomic Profiling of Non-Small Cell Lung Cancer (ICON), 2018 - 2019

Member, Immunophenotyping Working Group - Immunogenomic Profiling of Non-Small Cell Lung Cancer (ICON), 2017 - 2019

Member, Clinical Data Working Group - Immunogenomic Profiling of Non-Small Cell Lung Cancer (ICON), 2017 - 2019

Honors & Awards

2025	Invited Attendee, Society of Thoracic Surgeons Leadership Institute
2024	Jeffrey Lee Cousins Endowed Fellowship in Lung Cancer Research, University of Texas MD Anderson Cancer Center
2024	Champion - Postgraduate Symposium Master Cup, European Society of Thoracic Surgeons 32nd Annual Meeting
2023	Invited Attendee, American Association of Thoracic Surgery (AATS) Leadership Academy, AATS 103rd Annual Meeting
2023	Champion - Cardiothoracic Surgery Resident Showdown, Society of Thoracic Surgeons 59th Annual Meeting
2023	Director's Award for Excellence in Patient Care, Department of Cardiothoracic and Vascular Surgery, University of Texas McGovern Medical School
2022	Hairiest Trauma of the Year, Department of Surgery, University of Texas McGovern Medical School
2021	Raleigh Ross Scholar, Texas Surgical Society
2020	Best Basic Science/Translational Abstract, University of Texas McGovern Medical School Department of Surgery Research Forum
2019	Best Basic Science/Translational Abstract, University of Texas McGovern Medical School, Department of Surgery Research Forum
2017	Looking to the Future Resident Scholarship, Society of Thoracic Surgeons 53rd Annual Meeting
2016	Intern of the Year, Department of Surgery - University of Texas McGovern Medical School
2015	Alpha Omega Alpha, Delta Chapter of Texas - University of Texas McGovern Medical School
2013	Best Abstract, Second Annual Research Forum, University of Texas McGovern Medical School
2012	C. Frank Webber Prize Nominee, University of Texas McGovern Medical School

Professional Memberships

European Society of Thoracic Surgeons

2024 - Present

Southern Thoracic Surgical Association

2022 - Present

Society of Thoracic Surgeons

2021 - Present

Thoracic Surgery Residents Association

2020 - 2024

Selected Publications

Peer-Reviewed Articles

Antonoff MB, Mitchell KG, Kim SS, Salfity HV, Kotova S, Ripley RT, Neri AL, Sood P, Gandhi SG, Elamin YY, Donington JS, Jones DR, David EA, Swisher SG, Opitz I, Hayanga JWA, Rocco G. The Society of Thoracic Surgeons (STS) Clinical Practice Guideline on Surgical Management of Oligometastatic Non-small Cell Lung Cancer. Ann Thorac Surg. e-Pub 2025. PMID: 39797869.
Mitchell KG, Feldman H, Milton DR, Antonoff MB, Hofstetter WL, Rice DC, Vaporciyan AA, Lin R, Thall PF, Rajaram R, MD Anderson Cancer Center Esophageal Adenocarcinoma Study Group. Signet Ring Cells and Conditional Survival After Trimodality Therapy for Esophageal Adenocarcinoma. J Surg Oncol 130(3):428-434, 2024. e-Pub 2024. PMID: 39004940.
Deboever N, Mitchell KG, Farooqi A, Ludmir EB, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Heymach JV, Gomez DR, Gandhi SJ, Antonoff MB. Perioperative and Oncologic Outcomes of Pulmonary Resection for Synchronous Oligometastatic Non-Small Cell Lung Cancer: Evidence for Surgery in Advanced Disease. J Thorac Cardiovasc Surg 167(6):1929-1935.e2, 2024. e-Pub 2024. PMID: 37619884.
Leng X, Kurita D, Zhu Y, Abe S, Zhang R, Guo X, Dai L, Wong IYH, Park SY, van der Wilk BJ, Gao X, Chen Y, Zhao R, Lv J, Qing H, Liu Y, Mitchell KG, Wijnhoven BPL, Han Y, Daiko H. Collaborative Multidisciplinary Management and Expertise of cT2-3 Locally Advanced Operable Esophageal Squamous Cell Carcinoma: A Report of Two Cases. J Thorac Dis 15(11):6362-6372, 2023. e-Pub 2023. PMID: 38090303.
Mitchell KG, Dobrila J, Podgorsek B, Greenleaf C, Chen P, Salazar JD, LaPar DJ. Aortic Arch Reconstruction Using Non-Valved Femoral Vein Homograft in High-Risk Neonates. World J Pediatr Congenit Heart Surg 14(6):754-756, 2023. e-Pub 2023. PMID: 37697743.
Cangut B, Mitchell KG, Antonoff MB. The 7 Pillars of Training Minimally Invasive Thoracic Surgery: Embracing the Virtual Era. Innovations (Phila) 18(5):414-418, 2023. e-Pub 2023. PMID: 37743743.
Mitchell KG, Bayley EM, Ikoma N, Antonoff MB, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Maru DM, Erasmus JJ, Weston BR, Ajani JA, Badgwell BD, Hofstetter WL. Gastric Extent of Tumor Predicts Peritoneal Metastasis in Siewert II Adenocarcinoma. Ann Thorac Surg S0003-4975(23):00395-8, 2023. e-Pub 2023. PMID: 37080372.
Mitchell KG, Podgorsek B, Fiorito DE, Abreu JA, Ramzy D. Robotic-Assisted Resection of Left Ventricular Papillary Fibroelastoma Arising From the Mitral Chordal Apparatus. Innovations (Phila.) 18(1):100-102, 2023. e-Pub 2023. PMID: 36782085.
De B, Farooqi AS, Mitchell KG, Ludmir EB, Vaporciyan AA, Swisher SG, Zhang J, Le X, Gomez DR, Elamin Y, Ning MS, Lin SH, Liao Z, Chang JY, Heymach JV, Antonoff MB, Gandhi SJ. Benchmarking Outcomes for Molecularly Characterized Synchronous Oligometastatic Non-Small-Cell Lung Cancer Reveals EGFR Mutations to Be Associated With Longer Overall Survival. JCO Precision Oncology 7, 2023. e-Pub 2023. PMID: 36716413.
Zhou N, Hofstetter WL, Esophageal Squamous Cell Carcinoma Working Group. Salvage Esophagectomy Definition Influences Comparative Outcomes in Esophageal Squamous Cell Cancers. Ann Thorac Surg 114(6):2032-2040, 2022. e-Pub 2022. PMID: 34883083.
Gupta VS, Ferguson DM, Lally PA, Garcia EI, Mitchell KG, Tsao K, Harting MT. Birth Weight Predicts Patient Outcomes in Infants Who Undergo Congenital Diaphragmatic Hernia Repair. J Matern Fetal Neonatal Med 35(25):6823-6829, 2022. e-Pub 2022. PMID: 33998394.
Sepesi B, Zhou N, William Jr WN, Lin H, Leung CH, Weissferdt A, Mitchell KG, Pataer A, Walsh GL, Rice DC, Roth JA, Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Negrao MV, Tsao AS, Gibbons DL, Lee JJ, Heymach JV, Vaporciyan AA, Swisher SG, Cascone T. Surgical Outcomes After Nivolumab or Nivolumab With Ipilimumab in Patients With Non-Small Cell Lung Cancer. J Thorac Cardiovasc Surg 164(5):1327-1337, 2022. e-Pub 2022. PMID: 35190177.
Olive JK, Zhou N, Mitchell KG, Corsini EM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB. Impact of Psychiatric Comorbidities on Surgical Outcomes for Non-Small Cell Lung Cancer. Ann Thorac Surg 113(3):1008-1014, 2022. e-Pub 2022. PMID: 33774003.
Antonoff MB, Feldman HA, Mitchell KG, Farooqi AS, Ludmir EB, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Sepesi B, Swisher SG, Walsh GL, Gandhi S, Gomez DR, Vaporciyan AA. Surgical Complexity of Pulmonary Resections Performed for Oligometastatic NSCLC. JTO Clin Res Rep 3(3):100288, 2022. e-Pub 2022. PMID: 35252897.
Deboever N, McGrail DJ, Lee Y, Tran HT, Mitchell KG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Wistuba II, Bernatchez CC, Cascone T, Zhang J, Heymach JV, Gibbons DL, Haymaker CL, Sepesi B. Surgical Approach Does Not Influence Changes in Circulating Immune Cell Populations Following Lung Cancer Resection. Lung Cancer 164:69-75, 2022. e-Pub 2022. PMID: 35038676.
Mitchell KG, Bostock IC, Antonoff MB. Social Disparities in Thoracic Surgery Database Research: Impact and Implications. Thorac Surg Clin 32(1):83-90, 2022. e-Pub 2022. PMID: 34801199.
Shah P, Forget MA, Frank ML, Federico L, Jiang P, Khairullah R, Wistuba II, Chow CW, Long Y, Fujimoto J, Lin SY, Maitra A, Negrao MV, Mitchell KG, Weissferdt A, Vaporciyan AA, Cascone T, Roth J, Zhang J, Sepesi B, Gibbons DL, Heymach JV, McGrail DJ, Reuben AR, Bernatchez C. Combined IL-2, Agonistic CD3 and 4-1BB Stimulation Preserve Clonotype Hierarchy in Propagated Non-Small Cell Lung Cancer Tumor-Infiltrating Lymphocytes. J Immunother Cancer 10(2):e003082, 2022. e-Pub 2022. PMID: 35110355.
Saddoughi SA, Mitchell KG, Antonoff MB, Fruth KM, Taswell J, Mounajjed, Hofstetter WL, Rice DC, Shen KR, Blackmon SH. Analysis of Esophagectomy Margin Practice and Survival Implications. Ann Thorac Surg 113(1):209-216, 2022. e-Pub 2022. PMID: 33524359.
Luc JGY, Corsini EM, Mitchell KG, Correa AM, Turner NS, Vaporciyan AA, Antonoff MB. Effect of Operating Room Personnel Generation on Perceptions and Responses to Surgeon Behavior. Am Surg 87(12):1934-1945, 2021. e-Pub 2021. PMID: 34553636.
Corsini EM, Foo WC, Mitchell KG, Zhou N, Maru DM, Ajani JA, Hofstetter WL, Esophageal Adenocarcinoma Working Group. Esophageal Adenocarcinoma With Any Component of Signet Ring Cells Portends Poor Prognosis and Response to Neoadjuvant Therapy. J Thorac Cardiovasc Surg 162(5):1404-1412.e2, 2021. e-Pub 2021. PMID: 33010880.
Zhou N, Mitchell KG, Corsini EM, Truong VTT, Antonoff MB, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Ajani JA, Hofstetter WL. Analysis of Trimodal and Bimodal Therapy in a Selective-Surgery Paradigm for Locally Advanced Oesophageal Squamous Cell Carcinoma. Br J Surg 108(10):1207-1215, 2021. e-Pub 2021. PMID: 34095952.
Farooqi A, Ludmir EB, Mitchell KG, Antonoff MB, Tang C, Lee P, Chang J, Elamin Y, Gomez D, Gandhi S. Increased Biologically Effective Dose (BED) to the Primary Tumor Is Associated With Improved Survival in Patients With Oligometastatic NSCLC. Radiother Oncol 163:114-118, 2021. e-Pub 2021. PMID: 34419505.
Corsini EM, Mitchell KG, Zhou N, Bernatchez C, Forget M, Haymaker CL, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Amaria RN, Jazaeri AA, Antonoff MB. Pulmonary Resection for Tissue Harvest in Adoptive Tumor-Infiltrating Lymphocyte Therapy: Safety and Feasibility. J Surg Oncol 124(4):699-703, 2021. e-Pub 2021. PMID: 34057733.
Corsini EM, Mitchell KG, Zhou N, Antonoff MB, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Hofstetter WL. Intestinal Metaplasia in the Esophageal Remnant Is Rare After Ivor Lewis Esophagectomy. J Gastrointest Surg 25(9):2185-2191, 2021. e-Pub 2021. PMID: 33555525.
Cascone T, Weissferdt A, Godoy MCB, Jr WW, Leung CH, Lin HY, Pataer A, Mitchell KG, Khan MAW, Shi Y, Ajami N, Wargo JA, Jenq RR, Gibbons DL, Lee JJ, Swisher SG, Vaporciyan AA, Heymach JV, Sepesi B. Nodal Immune Flare Mimics Nodal Disease Progression Following Neoadjuvant Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Nat Commun 12(1):5045, 2021. e-Pub 2021. PMID: 34413300.
Corsini EM, Mitchell KG, Antonoff MB, Mehran RJ, Rice DC, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Cinciripini P, Karam-Hage M, Roth JA, Hofstetter WL. Enhanced Recovery Protocols May Mitigate Effects of Continued Smoking Among Lung Cancer Patients. Ann Thorac Surg S0003-4975(21):01317-5, 2021. e-Pub 2021. PMID: 34358522.
Corsini EM, Mitchell KG, Zhou N, Antonoff MB, Mehran RJ, Mena GE, Rajaram R, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC, Hofstetter WL. Liposomal Bupivacaine Intercostal Block Is Important for Reduction of Pulmonary Complications. Ann Thorac Surg 112(2):423-429, 2021. e-Pub 2021. PMID: 33129774.
Negrao MV, Skoulidis F, Montesion M, Schulze K, Bara I, Shen V, Hu S, Sui D, Elamin YY, Le X, Goldberg ME, Murugesan K, Wu CJ, Zhang J, Barreto DS, Robichaux JP, Reuben A, Cascone T, Gay CG, Mitchell KG, Hong L, Rinsurongkawong W, Roarty EB, Simon G, Roth J, Swisher S, Lee JJ, Tsao A, Papadimitrakopoulou V, Gibbons DL, Glisson BS, Singal G, Miller VA, Alexander BM, Frampton GM, Albacker LA, Shames DS, Zhang J, Heymach JV. Oncogene-Specific Differences in Tumor Mutational Burden, PD-L1 Expression, and Outcomes From Immunotherapy in Non-Small Cell Lung Cancer. J Immunother Cancer 9(8):e002891, 2021. e-Pub 2021. PMID: 34376553.
Mitchell KG, Feldman H, Meyers BF, Antonoff MB. Chyloptysis as a Delayed Sequela of Penetrating Thoracic Trauma. JTCVS Tech 9:180-182, 2021. e-Pub 2021. PMID: 34647094.
Corsini EM, Mitchell KG, Correa A, Morris VK, Antonoff MB, MD Anderson Pulmonary Metastasectomy Working Group. Impact of Laterality of Primary Colorectal Cancer Tumor Location on Survival After Pulmonary Metastasectomy. J Thorac Cardiovasc Surg 162(1):296-305, 2021. e-Pub 2021. PMID: 32713636.
Rocha P, Salazar R, Zhang J, Ledesma D, Solorzano JL, Mino B, Villalobos P, Diao L, Mitchell KG, Le X, Zhang J, Weissferdt A, Parra-Cuentas E, Cascone T, Rice DC, Sepesi B, Kalhor N, Moran C, Vaporciyan A, Heymach J, Gibbons D, Lee JJ, Kadara H, Wistuba I, Behrens C, Solis L. CD73 Expression Defines Immune, Molecular and Clinicopathologic Subgroups of Lung Adenocarcinoma. Cancer Immunol Immunother 70(7):1965-1976, 2021. e-Pub 2021. PMID: 33416944.
Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Sepesi B, Gomez DR, Antonoff MB, MD Anderson Cancer Center Oligometastatic Lung Cancer Working Group. Pulmonary Resection Is Associated With Long-Term Survival and Should Remain a Therapeutic Option in Oligometastatic Lung Cancer. J Thorac Cardiovasc Surg 161(4):1497-1504, 2021. e-Pub 2021. PMID: 32331820.
Corsini EM, Mitchell KG, Zhou N, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Maru DM, Lin SH, Ajani JA, Hofstetter WL. Modified En Bloc Esophagectomy Compared to Standard Resection After Neoadjuvant Chemoradiation. Ann Thorac Surg 111(4):1133-1140, 2021. e-Pub 2021. PMID: 32857997.
Zhou N, Bott M, Park BJ, Vallieres E, Wilshire CL, Yasufuku K, Spicer JD, Jones DR, Sepesi B, Small Cell Lung Cancer Working Group. Predictors of Survival Following Surgical Resection of Limited Stage Small Cell Lung Cancer. J Thorac Cardiovasc Surg 161(3):760-771.e2, 2021. e-Pub 2021. PMID: 33349449.
Corsini EM, Hofstetter WL, MD Anderson Esophageal Cancer Working Group. Ketorolac Use and Anastomotic Leak in Esophageal Cancer Patients. J Thorac Cardiovasc Surg 161(2):448-454, 2021. e-Pub 2021. PMID: 32340809.
Gaudreau PO, Negrao MV, Mitchell KG, Reuben A, Corsini EM, Li J, Karpinets T, Wang Q, Diao L, Wang J, Federico L, Parra ER, Behrens C, Correa AM, Gomez D, Vaporciyan AA, Weissferdt A, Tran H, Roarty EB, Haymaker CL, Bernatchez C, Cascone T, Zhang J, Cascone T, Futreal PA, Wistuba II, Heymach JV, Sepesi B, Zhang J, Gibbons DL. Neoadjuvant Chemotherapy Increases Cytotoxic T Cell, Tissue Resident Memory T Cell and B Cell Infiltration in Resectable Non-Small Cell Lung Cancer. J Thorac Oncol 16(1):127-139, 2021. e-Pub 2021. PMID: 33096269.
Mitchell KG, Parra ER, Zhang J, Nelson DB, Corsini EM, Villalobos P, Moran CA, Skoulidis F, Wistuba II, Fujimoto J, Roth JA, Antonoff MB, MD Anderson Lung Cancer Immune Microenvironment Working Group. LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence. Ann Thorac Surg 110(4):1131-1138, 2020. e-Pub 2020. PMID: 32442617.
Corsini EM, Mitchell KG, Mehran RJ, Sepesi B, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Hofstetter WL, Antonoff MB, Rice DC. Importance of Resection for Locoregional Disease Control in Masaoka Stage IVA Thymic Neoplasms. J Surg Oncol 122(3):515-522, 2020. e-Pub 2020. PMID: 32468580.
Hong L, Negrao MV, Dibaj S, Chen R, Reuben A, Skoulidis F, Gay CM, Cascone T, Mitchell KG, Tran HT, Le X, Byers L, Sepesi B, Altan M, Elamin Y, Fossella F, Kurie J, Lu C, Mott F, Tsao A, Rinsurongkawong W, Lewis J, Gibbons DL, Glisson BS, Jr BG, Roarty EB, Futreal A, Wistuba II, Roth JA, Swisher SG, Papadimitrakopoulou V, Heymach JV, Lee JJ, Simon G, Zhang J. Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit from Immune Checkpoint Inhibitors in NSCLC. J Thorac Oncol 15(9):1449-1459, 2020. e-Pub 2020. PMID: 32389639.
Mitchell KG, Amini B, Wang Y, Carter BW, Godoy MCB, Parra ER, Behrens C, Villalobos P, Reuben A, Lee JJ, Weissferdt A, Moran CA, Fujimoto J, Sepesi B, Walsh GL, Vaporciyan AA, Hofstetter WL, William WN, Gibbons DL, Wang J, Hwu P, Swisher SG, Piwnica-Worms D, Kadara H, Wistuba II, Heymach JV, Peng W, Cascone T. 18F-Fluorodeoxyglucose Positron Emission Tomography Correlates with Tumor Immunometabolic Phenotypes in Resected Lung Cancer. Cancer Immunol Immunother 69(8):1519-1534, 2020. e-Pub 2020. PMID: 32300858.
Corsini EM, Wang Q, Tran HT, Mitchell KG, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Reuben A, Vasquez ME, Bernatchez C, Wang J, Cascone T, Zhang J, Heymach JV, Gibbons DL, Haymaker CL, Sepesi B. Peripheral Cytokines Are Not Influenced by the Type of Surgical Approach for Non-Small Cell Lung Cancer by Four Weeks Postoperatively. Lung Cancer 146:303-309, 2020. e-Pub 2020. PMID: 32619781.
Corsini EM, Wang J, Wu C, Fujimoto J, Negrao MV, Chen R, Quek K, Mitchell KG, Chow CB, Little L, Gumbs C, Song X, Behrens C, Correa AM, Antonoff MB, Swisher SG, Heymach JV, Zhang J, Wistuba II, Futreal PA, Sepesi B, Zhang J. Genomic Assessment Distinguishes Intrapulmonary Metastases from Synchronous Primary Lung Cancers. J Thorac Dis 12(5):1952-1959, 2020. e-Pub 2020. PMID: 32642098.
Corsini EM, Datar SS, Mitchell KG, Zhou N, Rajaram R, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Hofstetter WL, Blackmon SH, Loree JM, Morris VK, Antonoff MB. High Mutational Concordance between Primary Colorectal Tumors and Associated Pulmonary Metastases. J Surg Oncol 121(6):984-989, 2020. e-Pub 2020. PMID: 32077113.
Mitchell KG, Diao L, Karpinets T, Negrao MV, Tran HT, Parra ER, Corsini EM, Reuben A, Federico L, Bernatchez C, Dejima H, Francisco-Cruz A, Wang J, Antonoff MB, Vaporciyan AA, Swisher SG, Cascone T, Wistuba II, Heymach JV, Gibbons DL, Zhang J, Haymaker CL, Sepesi B. Neutrophil Expansion Defines an Immunoinhibitory Intratumoral and Peripheral Inflammatory Milieu in Resected Non-Small Cell Lung Cancer: A Descriptive Analysis of a Prospectively Immunoprofiled Cohort. J Immunother Cancer 8(1):e000405, 2020. e-Pub 2020. PMID: 32350118.
Corsini EM, Mitchell KG, Nguyen TC, Vaporciyan AA, Antonoff MB. Cardiothoracic Surgery Mock Oral Examinations: A Single Institution’s 5-Year Experience. J Thorac Cardiovasc Surg 159(4):1439-1444, 2020. e-Pub 2020. PMID: 31256970.
Nelson DB, Mitchell KG, Wang J, Fujimoto J, Behrens C, Zheng X, Zhang J, Sepesi B, Vaporciyan AA, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Swisher SG, Moran CA, Kalhor N, Weissferdt A, Wistuba II, Roth JA, Antonoff MB. Immune Regulatory Markers of Lepidic-Pattern Adenocarcinomas Presenting as Ground Glass Opacities. J Thorac Dis 12(3):329-337, 2020. e-Pub 2020. PMID: 32274099.
Mitchell KG, Nelson DB, Corsini EM, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Sepesi B, Walsh GL, Bhutani MS, Maru DM, Wu CC, Nguyen QN, Ajani JA, Swisher SG, Hofstetter WL. Morbidity following Salvage Esophagectomy for Squamous Cell Carcinoma: The MD Anderson Experience. Dis Esophagus 33(3):doz067, 2020. e-Pub 2020. PMID: 31313820.
Mitchell KG, Negrao MV, Parra ER, Li J, Zhang J, Dejima H, Vaporciyan AA, Swisher SG, Weissferdt A, Antonoff MB, Cascone T, Roarty E, Wistuba II, Heymach JV, Gibbons DL, Zhang J, Sepesi B. Lymphovascular Invasion Is Associated with Mutational Burden and PD-L1 in Resected Lung Cancer. Ann Thorac Surg 109(2):358-366, 2020. e-Pub 2020. PMID: 31550464.
Nelson DB, Niu J, Mitchell KG, Vaporciyan AA, Hofstetter WL, Antonoff MB, Giordano SH, Sepesi B, Mehran RJ, Rice DC. Perioperative Outcomes among Chronic Opioid Users Who Receive Lobectomy for Non-Small Cell Lung Cancer. J Thorac Cardiovasc Surg 159(2):691-702, 2020. e-Pub 2020. PMID: 33003262.
Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Zhang J, Sepesi B, Vaporciyan AA, Swisher SG, Heymach JV, Zhang J, Gomez DR, Antonoff MB. Improved Overall Survival with Comprehensive Local Consolidative Therapy in Synchronous Oligometastatic Non-Small Cell Lung Cancer. Clin Lung Cancer 21(1):37-46, 2020. e-Pub 2020. PMID: 31447303.
Mitchell KG, Nelson DB, Corsini EM, Correa AM, Erasmus JJ, Hofstetter WL, Mehran RJ, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC, Nguyen QN, Antonoff MB. Surveillance after Treatment of Non-Small Cell Lung Cancer: A Call for Multidisciplinary Standardization. Innovations (Phila) 15(1):57-65, 2020. e-Pub 2020. PMID: 31875755.
Nelson DB, Niu J, Mitchell KG, Vaporciyan AA, Hofstetter WL, Antonoff MB, Giordano SH, Sepesi B, Mehran RJ, Rice DC. Persistent Opioid Use among the Elderly after Lung Resection: A SEER-Medicare Study. Ann Thorac Surg 109(1):194-202, 2020. e-Pub 2020. PMID: 31445908.
Nelson DB, Mitchell KG, Weston BR, Betancourt SL, Maru DP, Rice DC, Mehran RJ, Sepesi B, Antonoff MB, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Blum MA, Hofstetter WL. Should Endoscopic Resection Be Attempted for cT2N0 Esophageal Cancer?. Dis Esophagus 32(20):1-6, 2019. e-Pub 2019. PMID: 30888418.
Corsini EM, Luc JGY, Mitchell KG, Turner NS, Vaporciyan AA, Antonoff MB. Predictors of the Response of Operating Room Personnel to Surgeon Behaviors. Surg Today 49(11):927-935, 2019. e-Pub 2019. PMID: 31144105.
Nelson DB, Nguyen QN, Erasmus J, Tayob N, Mitchell KG, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB, Roth JA, Rice DC, Mehran RJ. Local Failure after Stereotactic Body Radiation Therapy or Wedge Resection for Colorectal Pulmonary Metastases. J Thorac Cardiovasc Surg 158(4):1234-1241, 2019. e-Pub 2019. PMID: 31395367.
Nelson DB, Cata JP, Nu J, Mitchell KG, Vaporciyan AA, Antonoff MB, Hofstetter WL, Giordano SH, Sepesi B, Mehran RJ, Rice DC. Persistent Opioid Use Is Associated with Worse Survival after Lobectomy for Stage I Non-Small Cell Lung Cancer. Pain 160(10):2365-2373, 2019. e-Pub 2019. PMID: 31149979.
Corsini EM, Mitchell KG, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG, Roth JA, Hofstetter WL, Vaporciyan AA, Morris VK, Antonoff MB. Colorectal Cancer Mutations Are Associated With Survival and Recurrence After Pulmonary Metastasectomy. J Surg Oncol 120(4):729-735, 2019. e-Pub 2019. PMID: 31290159.
Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff BM, Mehran RJ, Rice DC, Roth JA, Swisher SG, Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell DB, Hofstetter WL. Mediastinal Nodal Involvement After Neoadjuvant Chemoradiation for Siewert II/III Adenocarcinoma. Ann Thorac Surg 108(3):845-851, 2019. e-Pub 2019. PMID: 31102632.
Nelson DB, Rice DC, Mitchell KG, Tsao AS, Gomez DR, Sepesi B, Mehran RJ. Return to Intended Oncologic Treatment after Surgery for Malignant Pleural Mesothelioma. J Thorac Cardiovasc Surg 158(3):924-929, 2019. e-Pub 2019. PMID: 31430846.
Mitchell KG, Parra ER, Nelson DB, Zhang J, Wistuba II, Fujimoto J, Roth JA, Antonoff MB, Group MD. Tumor Cellular Proliferation Is Associated With Enhanced Immune Checkpoint Expression in Stage I Non-Small Cell Lung Cancer. J Thorac Cardiovasc Surg 158(3):911-919, 2019. e-Pub 2019. PMID: 3122537.
Mohammad Z, Mitchell KG, Nelson DB, Robb C, Jreissaty C, Tu J, Vaporciyan AA, Sepesi B, Antonoff MB. Lung Cancer Patient Perceptions of the Value of an Outreach Thoracic Surgical Clinic. Ann Thorc Surg 108(2):358-362, 2019. e-Pub 2019. PMID: 30928553.
Corsini EM, Mitchell KG, Sceusi EL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Swisher SG, Roth JA, Hofstetter WL, Vaporciyan AA, Antonoff MB. Multidisciplinary Treatment of Thymic Neuroendocrine Tumors: Surgery Remains a Key Component. J Thorac Dis 11(8):3391-3398, 2019. e-Pub 2019. PMID: 31559043.
Nelson DB, Mehran RJ, Mitchell KG, Rajaram R, Correa AM, Bassett RL, Antonoff MB, Hofstetter WL, Roth JA, Sepesi B, Swisher SG, Walsh GL, Vaporciyan AA, Rice DC. Robotic Assisted Lobectomy For Non-Small Cell Lung Cancer: A Comprehensive Single-Institution Experience. Ann Thorac Surg 108(2):370-376, 2019. e-Pub 2019. PMID: 31004583.
Nelson DB, Mitchell KG, Van Haren RM, Mena GE, Woodard T, Correa AM, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB, Roth JA, Heymach JV, Mehran RJ, Rice DC. Enhanced Recovery After Thoracic Surgery Is Associated with Improved Adjuvant Chemotherapy Completion for Non-Small Cell Lung Cancer. J Thorac Cardiovasc Surg 158(1):279-286, 2019. e-Pub 2019. PMID: 31014665.
Nelson DB, Tam AL, Mitchell KG, Rice DC, Mehran RJ, Sepesi B, Antonoff MB, Walsh GL, Swisher SG, Roth JA, Vaporciyan AA, Hofstetter WL. Local Recurrence After Microwave Ablation of Lung Malignancies: A Systematic Review. Ann Thorac Surg 107(6):1876-1883, 2019. e-Pub 2019. PMID: 30508527.
Nelson DB, Tayob N, Mitchell KG, Correa AM, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB, Roth JA, Rice DC, Vauthey NJ, Mehran RJ. Surgical Margins and Risk of Local Recurrence After Wedge Resection of Colorectal Pulmonary Metastases. J Thorac Cardiovasc Surg 157(4):1648-1655, 2019. e-Pub 2019. PMID: 30635188.
Nelson DB, Rice DC, Mitchell KG, Tsao AS, Vaporciyan AA, Antonoff MB, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Gomez DR, Mehran RJ, Sepesi B. Defining the Role of Adjuvant Radiotherapy for Malignant Pleural Mesothelioma: A Propensity Matched Landmark Analysis of the National Cancer Database. J Thorac Dis 11(4):1269-1278, 2019. e-Pub 2019. PMID: 31179069.
Spicer JD, Shewale JB, Nelson DB, Mitchell KG, Bott MJ, Vallieres E, Wilkshire CL, Vaporciyan AA, Swisher SG, Jones DR, Darling GE, Sepesi B. Multimodality Therapy for N2 Non-Small Cell Lung Cancer: An Evolving Paradigm. Ann Thorac Surg 107(1):277-284, 2019. e-Pub 2019. PMID: 30227129.
Corsini EM, Maoz-Metzl D, Mitchell KG, Rice DC, Sepesi B. Mediastinal Esophageal Leiomyosarcoma Abutting a Retroesophageal Right Subclavian Artery: A Case Report. Int J Surg Case Rep 60:281-283, 2019. e-Pub 2019. PMID: 31261048.
Mitchell KG, Corsini EM, Van Haren RM, Walsh GL, Sepesi B. A Case Report of a Midesophageal Diverticulum Masquerading as a Fibrovascular Esophageal Polyp. Int J Surg Case Rep 59:205-207, 2019. e-Pub 2019. PMID: 311181388.
Nelson DB, Lapid DJ, Mitchell KG, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB. Perioperative Outcomes for Stage I Non-Small Cell Lung Cancer: Difference Between Men and Women. Ann Thorac Surg 106(5):1499-1503, 2018. e-Pub 2018. PMID: 30118712.
Shewale JB, Mitchell KG, Nelson DB, Conley AP, Rice DC, Antonoff MB, Hofstetter WL, Walsh GL, Weissferdt A, MDACC Chest Wall Sarcoma Study Group, Sepesi B. Predictors of Survival Following Resection of Primary Sarcomas of the Chest Wall - A Large, Single-Institution Series. J Surg Oncol 118(3):518-524, 2018. e-Pub 2018. PMID: 30109699.
Sepesi B, Nelson DB, Mitchell KG, Gibbons DL, Heymach JV, Vaporciyan AA, Swisher SG, Roszik J. Prognostic Value of PD-L1 mRNA Sequencing Expression Profile in Non-Small Cell Lung Cancer. Ann Thorac Surg 105(6):1621-1626, 2018. e-Pub 2018. PMID: 29510096.
Nelson DB, Godoy MCB, Benveniste MF, Shewale JB, Spicer JD, Mitchell KG, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB. Clinicoradiographic Predictors of Aggressive Biology in Lung Cancer With Ground Glass Components. Ann Thorac Surg 106(1):235-241, 2018. e-Pub 2018. PMID: 29534957.
Sepesi B, Ye Y, Mitchell KG, Zhang L, Gu J, Ji L, Antonoff M,, Hofstetter WL, Rice DC, Mehran RJ, Walsh G, Vaporciyan AA, Swisher S, Roth J, Wu X. Genetic Variants in Cytokine Signaling Pathways and Clinical Outcomes in Early Stage Lung Cancer Patients. J Thorac Cardiovasc Surg 155(6):2635-2645, 2018. e-Pub 2018. PMID: 29548588.
Banki F,, Kaushik C, Roife D, Mitchell KG, Miller III C. Laparoscopic Repair of Large Hiatal Hernia Without the Need for Esophageal Lengthening With Low Morbidity and Raire Symptomatic Recurrence. Semin Thorac Cardiovasc Surg 29(3):418-425, 2017. e-Pub 2017. PMID: 29031705.
Banki F, Estrera A, Harrison R, Miller C, Leake S, Mitchell KG, Khalil K, Safi H, Kaiser L. Pneumomediastinum: Etiology and a Guide to Diagnosis and Treatment. Am J Surg 206(6):1001-6, 2013. e-Pub 2013. PMID: 24296102.
Hooda Z, Zhigang D, Ries S, Antonoff M, Hofstetter W, Mehran R, Mitchell KG, Rice D, Swisher S, Vaporciyan A, Walsh G, Rajaram R. Association of Medicaid Expansion With Timely Treatment and Access to High-Volume Hospitals in Early-Stage Lung Cancer Patients. Ann Thorac Surg.

Invited Articles

Mitchell KG, Antonoff MB. Encouraging Early Outcomes in CALGB/Alliance 140503: Patient Selection, Not Extent of Resection, Is the Key to Perioperative Success. Ann Transl Med 7(Suppl 1):S50, 2019. e-Pub 2019. PMID: 31032329.

Editorials

Mitchell KG, Antonoff MB. Commentary: Old Data Provide New Insights Into the Therapeutic Benefit of Adjuvant Chemotherapy in Non-Small Cell Lung Cancer. Semin Thorac Cardiovasc Surg S1043-0679(22):00269-6, 2022. PMID: 36400354.
Mitchell KG, Antonoff MB. Pulmonary Resection Remains a Salvage Option Following Local Failure of Definitive Radiotherapy. Ann Thorac Surg S0003-4975(21):1838-5, 2021. PMID: 34740585.

Abstracts

Luo Q, Negrao MV, Parra ER, Ahave N, Bayley EM, Mitchell K, Zhang J, Heymach JV, Sepesi B, Wistuba I, Gibbons DL, Reuben A. Proximity Between Cytotoxic Antigen-Experienced T Cells and Tumor Cells Is Associated With Improved Clinical Outcomes in Early-Stage NSCLC. J Immunother Cancer 9, 2021. e-Pub 2021.
Frank M, Shah P, Forget MA, Federico L, Jiang P, Khairullah R, Wistuba I, Chow CW, Long Y, Fujimoto J, Lin SY, Maitra A, Negrao MV, Mitchell K, Weissferdt A, Vaporciyan AA, Cascone T, Roth J, Zhang J, Sepesi B, Gibbons DL, Heymach JV, Haymaker C, McGrail DJ, Bernatchez C, Reuben A. Combined IL-2, Agonistic CD3 and 4-1BB Stimulation Preserve Clonotype Hierarchy in Propagated Non-Small Cell Lung Cancer Tumor-Infiltrating Lymphocytes. J Immunother Cancer 9, 2021. e-Pub 2021.
Corsini E, Mitchell K, Zhou N, Antonoff M, Mehran R, Rajaram R, Rice D, Roth J, Sepesi B, Swisher S, Vaporciyan A, Walsh G, Hofstetter W. Intestinal Metaplasia in the Esophageal Remnant Is Rare After Ivor Lewis Esophagectomy. Dis Esophagus 33(Supplement_1):doaa087-14, 2020. e-Pub 2020.
Corsini E, Mitchell K, Zhou N, Antonoff M, Mehran R, Rice D, Roth J, Sepesi B, Swisher S, Vaporciyan A, Walsh G, Karam-Hage M, Hofstetter W. Preoperative Tobacco Cessation and Major Postoperative Morbidity in Patients Undergoing Esophagectomy. Dis Esophagus 33(Supplement_1):doaa087-15, 2020. e-Pub 2020.
Corsini EM, Shroff G, Betancourt SL, Mitchell KG, Zhou N, Pan T, Rauch G, Antonoff MB, Wu C. Multi-Planar Lung Cancer Measurements Provide Improved Accuracy in Clinical Staging. J Thorac Oncol 14(11):S1130-S1131, 2019. e-Pub 2019.
Gaudreau P, Negrao M, Mitchell K, Corsini E, Karpinets T, Wang Q, Diao L, Wang J, Federico L, Parra E, Li J, Behrens C, Correa A, Gomez D, Vaporciyan A, Weissferdt S, Tran H, Roarty E, Wistuba I, Reuben A, Haymaker C, Bernatchez C, Cascone T, Heymach J, Sepesi B, Zhang J, Gibbons D. Neoadjuvant Chemotherapy Is Associated With Immunogenic Cell Death and Increased T Cell Infiltration in Early-Stage NSCLC. J Thorac Oncol 14(10):S715, 2019. e-Pub 2019.
Corsini EM, Lai L, Lewis J, Mitchell KG, Vaporciyan AA, Huynh TT, Pisimisis GT. Spontaneous Aortic Thrombosis in the Oncologic Population: A Single Center Experience. J Emerg Med 57(3):426-427, 2019. e-Pub 2019.
Mitchell KG, Diao L, Tran HT, Negrao MV, Karpinets T, Wang J, Parra Cuentas ER, Corsini EM, Reuben A, Federico L, Bernatchez D, Vaporciyan AA, Swisher S, Cascone T, Wistuba II, Heymach J, Zhang J, Gibbons DL, Haymaker DL, Sepesi B. Association of Relative Neutrophilia With a Distinct Immunoinhibitory Milieu in Non-Small Cell Lung Cancer. J Clin Oncol 37(15_suppl):e14047, 2019. e-Pub 2019.
Mitchell KG, Farooqi A, Ludmir EB, Corsini EM, Vaporciyan AA, Swisher SG, Heymach J, Zhang J, Gomez DR, Antonoff MB. Improved Overall Survival With Local Consolidative Therapy in Oligometastatic Non-Small Cell Lung Cancer: Results From a Cohort of 194 Patients With Synchronous Disease. Int J Radiat Oncol Biol Phys 104(1):229, 2019. e-Pub 2019.
Corsini EM, Mitchell KG, Mehran R, Rice DC, Sepesi B, Walsh G, Swisher SG, Roth J, Vaporciyan AA, Hofstetter W, Antonoff MB. Multidisciplinary Treatment of Thymic Neuroendocrine Tumors: Evaluation of the Impact of Surgery, Chemotherapy, and Radiation. Int J Radiat Oncol Biol Phys 104(1):231-232, 2019. e-Pub 2019.

Book Chapters

Mitchell KG, Sepesi B. Pleurectomy and Decortication. In: Operative Dictations in Cardiothoracic Surgery. 2, 2023.
Mitchell KG, Nelson DB, Hofstetter WL. Squamous Cell Carcinoma of the Esophagus. In: Complex General Surgical Oncology. Decker, 2019.

Letters to the Editor

Corsini EM, Mitchell KG, Antonoff MB. Response to Letter to the Editor. J Surg Oncol 120: 1051-1052, 2019.

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Selected Presentations & Talks

Local Presentations

2024. Local Consolidation in Oligometastatic Non-Small Cell Lung Cancer: Translational Insights and Therapeutic Opportunities. Invited. Grand Rounds. Houston, Texas, US.
2018. Thoracic Surgical Oncology: An Overview. Invited. Resident ABSITE Review Conference. Houston, Texas, US.
2014. Nemaline Rod Myopathy. Invited. Pediatric Neurology Grand Rounds. Houston, Texas, US.

National Presentations

2025. How to Make the Most of the STS Annual Meeting as a Trainee. Invited. 61st Annual STS Meeting. Los Angeles, CA, US.
2025. Make the Leap: How to Succeed in the First Year. Invited. STS 61st Annual Meeting. Los Angeles, CA, US.
2025. Lung Cancer Challenges in Resectable Disease: It's a Whole New World. Conference. STS 61st Annual Meeting. Los Angeles, CA, US.
2024. Postgraduate Video Session: Cardiothoracic Movie Night. Panelist. Southern Thoracic Surgical Association 71st Annual Meeting. Austin, TX, US.

International Presentations

2025. Salvage Surgery Post IO: Contra. Panelist. European Association for Cardiothoracic Surgery (EACTS) Academy 2025. Virtual.
2024. Oral Posters of Distinction. Poster. 20th ISDE World Congress for Esophageal Diseases. Edinburgh, GB.
2024. Esophagus: The Most Unforgiving Organ. Invited. 20th International Society for Disease of the Esophagus World Congress for Esophageal Diseases. Edinburgh, GB.
2024. Late-Breaking Oral Abstracts Session 2: Surgical and Interventional Approaches for Esophgeal Malignancies. Conference. 20th ISDE World Congress for Esophageal Diseases. Edinburgh, GB.
2023. Clinical Trials in Esophageal Cancer in the United States: An Update. Invited. The 4th East Asia Esophageal Cancer Multi-Disciplinary Team Academic Conference. Chengdu (Virtual), CN.
2022. Organ Preservation in Esophageal Squamous Cell Carcinoma: The MD Anderson Cancer Center Experience. Invited. Esophageal Cancer Grand Rounds Webinar Series. Virtual, CN.

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