Kyle R. Noll, Ph.D.
Department of Neuro-Oncology, Division of Cancer Medicine
About Dr. Noll
Kyle Noll, PhD, is a clinical neuropsychologist and associate professor in the Department of Neuro-Oncology. He provides comprehensive neuropsychological assessment for patients with cancer-related cognitive, emotional, and behavioral changes. He also offers interventions and assists with treatment planning to ameliorate or prevent cognitive and behavioral difficulties in adult cancer patients. He also serves as a supervisor to neuropsychology fellows within the Section of Neuropsychology's postdoctoral training program and to rotating trainees from other Texas Medical Center i nstitutions. Noll's research activities focus on understanding contributors to neurocognitive dysfunction in patients with primary brain tumors, including relationships between tumor, genetic, and sociodemographic characteristics. Noll joined MD Anderson in 2015.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2011 | The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA, PHD, unknown |
| 2007 | New York University, New York, NY, USA, MA, unknown |
| 2004 | The University of Texas at Austin, Austin, TX, USA, BA, unknown |
Postgraduate Training
| 2013-2014 | Research Fellow, Clinical Neuropsychology, The University of Texas M. D. Anderson Cancer Center, Houston, TX |
| 2011-2013 | Postdoctoral Fellow, Clinical Neuropsychology, Baylor College of Medicine, Houston, TX |
Board Certifications
| 2017 | American Board of Professional Psychology Certified in Clinical Neuropsychology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Neuro-Oncology, Section of Neuropsychology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2022
Institutional Committee Activities
Member, MD Anderson Faculty Senate, 2020 - 2023
Clinical Stakeholder, MD Anderson IO Toxicity, 2020 - Present
Neuropsychology Lead, MD Anderson Interdisciplinary Awake Craniotomy Team, 2018 - Present
Member, MD Anderson Psychologists Credentialing Committee, 2017 - Present
Honors & Awards
| 2010 | National Academy of Neuropsychology Student Poster Award |
| 2007 | MA Scholar Distinction, New York University |
| 2004 | Phi Beta Kappa, The University of Texas at Austin |
| 2002 | Hibbs Award for Philosophical Writing, The University of Texas at Austin |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Yeh MY, Chen HS, Hou P, Kumar VA, Johnson JM, Noll KR, Prabhu SS, Ferguson SD, Schomer DF, Peng HH, Liu HL. Cerebrovascular Reactivity Mapping Using Resting-State Functional MRI in Patients With Gliomas. J Magn Reson Imaging 56(6):1863-1871, 2022. e-Pub 2022. PMID: 35396789.
- Noll KR, Wefel J. On the classification of impairment in neuropsychological research and practice in the neuro-oncological setting. Neurooncol Pract 9(4):255-256, 2022. e-Pub 2022. PMID: 35859538.
- Muir M, Patel R, Traylor J, de Almeida Bastos DC, Prinsloo S, Liu HL, Noll K, Wefel J, Tummala S, Kumar V, Prabhu S. Validation of Non-invasive Language Mapping Modalities for Eloquent Tumor Resection: A Pilot Study. Front Neurosci 16:833073, 2022. e-Pub 2022. PMID: 35299624.
- Chen HS, Kumar VA, Johnson JM, Chen MM, Noll KR, Hou P, Prabhu SS, Schomer DF, Liu HL. Effect of brain normalization methods on the construction of functional connectomes from resting-state functional MRI in patients with gliomas. Magn Reson Med 86(1):487-498, 2021. e-Pub 2021. PMID: 33533052.
- Noll KR, Chen HS, Wefel JS, Kumar VA, Hou P, Ferguson SD, Rao G, Johnson JM, Schomer DF, Suki D, Prabhu SS, Liu HL. Alterations in functional connectomics associated with neurocognitive changes following glioma resection. Neurosurgery 88(3):544-551, 2021. e-Pub 2020. PMID: 33080024.
- Hsu AL, Chen HS, Hou P, Wu CW, Johnson JM, Noll KR, Prabhu SS, Ferguson SD, Kumar VA, Schomer DF, Chen JH, Liu HL. Presurgical resting-state functional MRI language mapping with seed selection guided by regional homogeneity. Magn Reson Med 84(1):375-383, 2020. e-Pub 2019. PMID: 31793025.
- Kumar VA, Heiba IM, Prabhu SS, Chen MM, Colen RR, Young AL, Johnson JM, Hou P, Noll K, Ferguson SD, Rao G, Lang FF, Schomer DF, Liu HL. The role of resting-state functional MRI for clinical preoperative language mapping. Cancer Imaging 20(1):47, 2020. e-Pub 2020. PMID: 32653026.
- Quirarte JA, Kumar VA, Liu HL, Noll KR, Wefel JS, Lang FF. Language supplementary motor area syndrome correlated with dynamic changes in perioperative task-based functional MRI activations: case report. J Neurosurg:1-5. e-Pub 2020. PMID: 32502992.
- Estevis E, Noll KR, Bradshaw ME, Wefel JS. Driver safety in patients with primary brain tumors. Neurooncol Pract 6(6):490-498, 2019. e-Pub 2019. PMID: 31832220.
- Noll KR, Bradshaw ME, Parsons MW, Dawson EL, Rexer J, Wefel JS. Monitoring of Neurocognitive Function in the Care of Patients with Brain Tumors. Curr Treat Options Neurol 21(7):33, 2019. e-Pub 2019. PMID: 31250277.
- Noll KR, Sullaway CM, Wefel JS. Depressive symptoms and executive function in relation to survival in patients with glioblastoma. J Neurooncol 142(1):183-191, 2019. e-Pub 2019. PMID: 30680509.
- Noll KR, Bradshaw ME, Weinberg JS, Wefel JS. Neurocognitive functioning is associated with functional independence in newly diagnosed patients with temporal lobe glioma. Neurooncol Pract 5(npx028):184-193, 2018. e-Pub 2017. PMID: 30094046.
- Hsu AL, Hou P, Johnson JM, Wu CW, Noll KR, Prabhu SS, Ferguson SD, Kumar VA, Schomer DF, Hazle JD, Chen JH, Liu HL. IClinfMRI software for integrating functional MRI techniques in presurgical mapping and clinical studies. Front Neuroinform 12:11, 2018. e-Pub 2018. PMID: 29593520.
- Weng HH, Noll KR, Johnson JM, Prabhu SS, Tsai YH, Chang SW, Huang YC, Lee JD, Yang JT, Yang CT, Tsai YH, Yang CY, Hazle JD, Schomer DF, Liu HL. Accuracy of Presurgical Functional MR Imaging for Language Mapping of Brain Tumors: A Systematic Review and Meta-Analysis. Radiology 286(2):512-23, 2018. e-Pub 2017. PMID: 28980887.
- Noll KR, Bradshaw ME, Weinberg JS, Wefel JS. Relationships between neurocognitive functioning, mood, and quality of life in patients with temporal lobe glioma. Psychooncology 26(5):617-624, 2017. e-Pub 2015. PMID: 26677053.
- Kesler SR, Noll K, Cahill DP, Rao G, Wefel JS. The effect of IDH1 mutation on the structural connectome in malignant astrocytoma. J Neurooncol 131(3):565-574, 2017. e-Pub 2016. PMID: 27848136.
- Wefel JS, Noll KR, Rao G, Cahill DP. Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection. Neuro Oncol 18(12):1656-1663, 2016. e-Pub 2016. PMID: 27576872.
- Noll KR, Ziu M, Weinberg JS, Wefel JS. Neurocognitive functioning in patients with glioma of the left and right temporal lobes. J Neurooncol 128(2):323-31, 2016. e-Pub 2016. PMID: 27022915.
- Wefel JS, Noll KR, Scheurer ME. Neurocognitive functioning and genetic variation in patients with primary brain tumours. Lancet Oncol 17(3):e97-108, 2016. e-Pub 2016. PMID: 26972863.
- Noll KR, Weinberg JS, Ziu M, Wefel JS. Verbal Learning Processes in Patients with Glioma of the Left and Right Temporal Lobes. Arch Clin Neuropsychol 31(1):37-46, 2016. e-Pub 2015. PMID: 26537777.
- Noll KR, Weinberg JS, Ziu M, Benveniste RJ, Suki D, Wefel JS. Neurocognitive Changes Associated With Surgical Resection of Left and Right Temporal Lobe Glioma. Neurosurgery 77(5):777-85, 2015. e-Pub 2015. PMID: 26317672.
- Noll KR, Sullaway C, Ziu M, Weinberg JS, Wefel JS. Relationships between tumor grade and neurocognitive functioning in patients with glioma of the left temporal lobe prior to surgical resection. Neuro Oncol 17(4):580-7, 2015. e-Pub 2014. PMID: 25227126.
- Wefel JS, Kesler SR, Noll KR, Schagen SB. Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA Cancer J Clin 65(2):123-38, 2015. e-Pub 2014. PMID: 25483452.
Invited Articles
- Noll K, King AL, Dirven L, Armstrong TS, Taphoorn MJB, Wefel JS. Neurocognition and health-related quality of life among patients with brain tumors. Hematol Oncol Clin North Am 36(1):269-282, 2022. e-Pub 2021. PMID: 34711455.
- Noll KR, Walbert T, Wefel JS. Impaired neurocognitive function in glioma patients: from pathophysiology to novel intervention strategies. Curr Opin Neurol 33(6):716-722, 2020. PMID: 33009006.
- Noll KR, Bradshaw ME, Rexer J, Wefel JS. Neuropsychological Practice in the Oncology Setting. Arch Clin Neuropsychol 33(3):344-353, 2018. PMID: 29718081.
Other Articles
- Noll KR Commentary: Presurgical Identification of Patients With Glioblastoma at Risk for Cognitive Impairment at 3-Month Follow-up. Neurosurgery. PMID: 32511696.
- Wefel JS, Noll KR, Rao G, Cahill DP Reply to Freyschlag et al. Neuro Oncol 19(4):598-599, 2017. PMID: 28339696.
- Wefel JS, Noll KR Therapies for cognitive deficits associated with chemotherapy for breast cancer: a systematic review of objective outcomes Morean DF, O'Dwyer L, Cherney LR. Breast Diseases 27(2):158-9, 2016.
- Noll KR, Wefel JS Response to "From histology to neurocognition: the influence of tumor grade in glioma of the left temporal lobe on neurocognitive function". Neuro Oncol 17(10):1421-2, 2015. PMID: 26395063.
- Noll KR, Fardell JE Commentary: "Neuropsychological Assessment of Individuals with Brain Tumor: Comparison of Approaches Used in the Classification of Impairment". Front Oncol 5:188, 2015. PMID: 26347854.
Abstracts
- Noll K, Mitchell D, Chen H, Wefel J, Kumar V, Hou P, Ferguson S, Rao G, Johnson J, Schomer D, Prabhu S, Liu HL. Alterations in structural connectomic properties associated with neurocognitive changes following glioma resection. Neuro Oncl 23(Supp 6):vi225, 2021.
- Yeh M, Gates E, Hou P, Kumar V, Johnson J, Noll K, Prabhu S, Ferguson S, Rao G, Schomer D, Liu HL. Cerebrovascular reactivity mapping using resting-state functional MRI in patient with gliomas. Medical Physics 47(6):E518, 2020.
- Warner A, Noll K. Semantic fluency performance is predictive of re-hospitalization in patients with recent onset psychosis. Schizophrenia Bulletin 56(Suppl 2):S223, 2019.
- Sheppard D, Noll K, Wefel J. Intra-individual neurocognitive variability in patients with cancer: a predictor and marker of neurotoxicity associated with chemotherapy?. Neuro-Oncology 20(Suppl 6, v173), 2018.
- Chen H, Noll K, Prabhu S, Kumar V, Hou P, Ferguson S, Rao G, Bradshaw M, Johnson J, Schomer D, Liu HL. Functional connectome analysis of FMRI before and after brain tumor resection. Medical Physics 45(6):E368, 2018.
- Noll K, Estevis E, Bradshaw M, Wefe J, Kesler S, Rexer J, Harmon C, Rhines S. Driver safety in patients with primary brain tumors. J Int Neuropsychol Soc 23(Suppl 1):v157, 2017.
- Noll, KR, Wang, X, Shi, Q, Wefel, J. Neurocognitive functioning, gender, and inflammatory markers in patients with colorectal cancer prior to chemotherapy. Journal of the International Neuropsychological Society 21(Suppl 1):292, 2015.
- Noll KR, Narang S, Martinez J, Rao G, Wefel J, Rao A. Relationships between tumor compartment volumes and neurocognitive functioning in patients with temporal lobe glioma. Neuro-Oncology 17(Suppl 5, v148), 2015.
- Demeriva P, Noll KR, Sellin J, Prabhu S, Wefel J. Neurocognitive changes associated with frontal lobectomy for right and left frontal lobe glioma. Neuro-Oncology 17(Suppl 5, v148-149), 2015.
- Noll KR, Narang S, Martinez J, Rao G, Wefel J, Rao A. Tumor volumetric and textural feature predictors of neurocognitive impairment in patients with temporal lobe glioma. Neuro-Oncology 17(Suppl 5, v148), 2015.
- Kesler S, Noll K, Cahill D, Rao G, Wefel J. Lower brain network efficiency in IDH1 wild type (IDH1-WT) malignant astrocytoma compared to IDH1 mutant (IDH1-M). Neuro-Oncology 17(Suppl 5, v163), 2015.
- Wefel J, Noll K, Rao G, Cahill D. Relationships between neurocognitive functioning and IDH1 genetic mutation status in malignant astrocytoma. Neuro-Oncology 16(Suppl 5, v137), 2014.
- Noll K, Garbarino A, Turner C, Verhaak AMS, Wefel J. Depression and executive functioning in relation to survival among patients with glioblastoma. Neuro-Oncology 16(Suppl 5, v136), 2014.
- Noll K, Greenberg BG, Hynan LS, Cullum CM, Taylor S, Harder LL, Lacritz LH. Predictors of quality of life in multiple sclerosis: Relationships between cognitive, physical, and subjective measures of disease burden. The Clinical Neuropsychologist 28:412, 2014.
- Noll K, Weinberg J, Ziu M, Turner C, Strange C, Wefel JS. Verbal learning and encoding strategies in patients with glioma of the right and left temporal lobes. Neuro-Oncology 15(Suppl 3, iii95), 2013.
- Bradshaw ME, Noll K, Ziu M, Weinberg J, Strange C, Turner C, Wefel JS. Neurocognitive functioning and functional status in patients with glioma of the temporal lobes. Neuro-Oncology 15(Suppl 3, iii92), 2013.
- Ziu M, Noll K, Weinberg J, Benveniste R, Turner C, Strange C, Suki D, Wefel JS. Neurocognitive functioning in patients with glioma of the right and left temporal lobes. Neuro-Oncology 15(Suppl 3, iii97), 2013.
- Turner C, Strange C, Witgert M, Noll K, Wefel JS. Quality of life, mood, and neurocognitive functioning in patients with temporal lobe glioma. Neuro-Oncology 15(Suppl 3, iii96), 2013.
- Noll K, Denney D, Taylor S, Greenberg B, Frohman E, Lacritz L. Relationships between retinal nerve fiber thickness and cognitive and motor functioning in multiple sclerosis. Journal of the International Neuropsychological Society 18(Suppl 1):23, 2012.
- Wiechmann A, Ritter A, Noll K, Taylor S, Greenberg B, Lacritz L. Test-retest reliability and practice effects of the Symbol Digit Modality Test in patients with demyelinating disease. Journal of the International Neuropsychological Society 18(Suppl 1):23, 2012.
- Wiechmann A, Carter K, Noll K, Lacritz L, Cullum CM. An alternate form of the Texas Card Sorting Test: A Pilot Study. Journal of the International Neuropsychological Society 18(Suppl 1):23, 2012.
- Noll K, Denney D, Wiechman A, Taylor S, Greenberg B, Lacritz LH. Comparison of short and standard form CVLT-II performances in a demyelinating disease population. Archives of Clinical Neuropsychology 26:c-36, 2011.
- Denney D, Noll K, Lacritz LH. Dyadic short forms of the Wechsler Adult Intelligence Scales-IV for estimating FSIQ and GAI. Journal of the International Neuropsychological Society 17(Suppl 1):284, 2011.
- Taylor SL, Noll K, Courtney A, Graves D, Frohman E, Mealy M, Lacritz L, Greenberg B. Lack of the PASAT, SDMT, or Judgment of Line tests to detect cognitive impairment in a cohort with demyelinating disease. Neurology 76(9):A485, 2011.
- Noll K, Cullum CM, O'Bryant S, Hall J, Simpson C, Lacritz LH. Normative data for logical memory story A in Alzheimer’s disease and normal controls. Archives of Clinical Neuropsychology 25:c-52, 2010.
- Arenivas A, Rossetti H, Rogerson M, Noll K, Lacritz L. Victoria Stroop test performance in multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Journal of the International Neuropsychological Society 16(Suppl 1):192, 2010.
Book Chapters
- Sabsevitz D, Elverman K, Noll K, Wefel J. Neuropsychologist's role in the management of brain tumor patients. In: Brain Mapping: Indications and Techniques. Thieme Publishers: New York, 2020.
- Noll K, Sabsevitz D, Prabhu S, Wefel J. Neuropsychology in the neurosurgical management of primary brain tumors. In: Neurosurgical Neuropsychology. Elsevier: San Diego, CA, 2018.
- Noll K, Wefel J. Quality of Life and Neurocognitive Function. In: Neuro-Oncology: The Essentials. 3rd. Thieme: New York, 2014.
- Noll K, Lacritz LH. Multiple sclerosis: Psychosocial factors. In: The Encyclopedia of Behavioral Medicine. Springer: New York, 2013.
- Noll K, Barisa M. Paroxysmal Hemicrania. In: The Encyclopedia of Neuropsychological Disorders. Springer: New York, 2010.
Grant & Contract Support
| Title: | Language mapping, neurocognitive functioning, and quality of life in patients with glioma |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center Survivorship Research Seed Grant |
| Role: | Principal Investigator |
| Title: | Resting-state functional MRI in glioma patients before and after surgery |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center Diagnostic Imaging Clinical Research Committee |
| Role: | Co-Investigator |
| Title: | Simulation of surgery-induced changes in brain connectomics and prediction of cognitive outcomes in patients with IDH1-mutant glioma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | A comprehensive clinical fMRI software solution to enable mapping of critical functional networks and cerebrovascular reactivity in the brain |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified July 02, 2024