Kyung Hee Chang, Ph.D.

Peer-Reviewed Articles

1. Roy S, Rai P, Eiymo Mwa Mpollo MS, Chang KH, Rizvi T, Shanmukhappa SK, VandenHeuvel K, Aronow B, Inagami T, Cancelas JA, Malik P. Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy. Am J Hematol 93(7):E177-E181, 2018. e-Pub 2018. PMID: 29675906.
2. González-Nieto D, Chang KH, Fasciani I, Nayak R, Fernandez-García L, Barrio LC, Cancelas JA. Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues. Int Rev Cell Mol Biol 318:27-62, 2015. e-Pub 2015. PMID: 26315883.
3. Chang KH, Nayak RC, Roy S, Perumbeti A, Wellendorf AM, Bezold KY, Pirman M, Hill SE, Starnes J, Loberg A, Zhou X, Inagami T, Zheng Y, Malik P, Cancelas JA. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation. Nat Commun 6:5914, 2015. e-Pub 2015. PMID: 25574809.
4. Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell Rep 9(6):2084-97, 2014. e-Pub 2014. PMID: 25533346.
5. Nayak RC, Chang KH, Vaitinadin NS, Cancelas JA. Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev 256(1):255-68, 2013. PMID: 24117826.
6. Taniguchi Ishikawa E*, Chang KH*, Nayak R, Olsson HA, Ficker AM, Dunn SK, Madhu MN, Sengupta A, Whitsett JA, Grimes HL, Cancelas JA (* Co-First/Equal authorship). Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking. Nat Commun 4:1660, 2013. PMID: 23552075.
7. Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Arnett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, Williams DA, Cancelas JA. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood 120(4):800-11, 2012. e-Pub 2012. PMID: 22692505.
8. Sengupta N, Afzal A, Caballero S, Chang KH, Shaw LC, Pang JJ, Bond VC, Bhutto I, Baba T, Lutty GA, Grant MB. Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest Ophthalmol Vis Sci 51(5):2697-704, 2010. e-Pub 2009. PMID: 20007826.
9. Kielczewski JL, Jarajapu YP, McFarland EL, Cai J, Afzal A, Li Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Boulton ME, Mames RN, Chan-Ling T, Grant MB. Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation. Circ Res 105(9):897-905, 2009. e-Pub 2009. PMID: 19762684.
10. Li Calzi S, Kent DL, Chang KH, Padgett KR, Afzal A, Chandra SB, Caballero S, English D, Garlington W, Hiscott PS, Sheridan CM, Grant MB, Forder JR. Labeling of stem cells with monocrystalline iron oxide for tracking and localization by magnetic resonance imaging. Microvasc Res 78(1):132-9, 2009. e-Pub 2009. PMID: 19345699.
11. Li Calzi S, Purich DL, Chang KH, Afzal A, Nakagawa T, Busik JV, Agarwal A, Segal MS, Grant MB. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. Diabetes 57(9):2488-94, 2008. e-Pub 2008. PMID: 18559661.
12. Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Li Calzi S, Sullivan SM, Grant MB. IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A 104(25):10595-600, 2007. e-Pub 2007. PMID: 17567755.
13. Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL, Kern TS, Grant MB. Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes 56(4):960-7, 2007. PMID: 17395742.
14. Segal MS, Shah R, Afzal A, Perrault CM, Chang K, Schuler A, Beem E, Shaw LC, Li Calzi S, Harrison JK, Tran-Son-Tay R, Grant MB. Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes 55(1):102-9, 2006. PMID: 16380482.
15. Chang KH, Lim JM, Kang SK, Lee BC, Moon SY, Hwang WS. An optimized protocol of a human-to-cattle interspecies somatic cell nuclear transfer. Fertil Steril 82(4):960-2, 2004. PMID: 15482781.
16. Chang KH, Lim JM, Kang SK, Lee BC, Moon SY, Hwang WS. Blastocyst formation, karyotype, and mitochondrial DNA of interspecies embryos derived from nuclear transfer of human cord fibroblasts into enucleated bovine oocytes. Fertil Steril 80(6):1380-7, 2003. PMID: 14667873.
17. Kwun J, Chang K, Lim J, Lee E, Lee B, Kang S, Hwang W. Effects of exogenous hexoses on bovine in vitro fertilized and cloned embryo development: Improved blastocyst formation after glucose replacement with fructose in a serum-free culture medium. Mol Reprod Dev 65(2):167-74, 2003. PMID: 12704727.

Abstracts

1. Kyung-Hee Chang, Amitava Sengupta, Ramesh C Nayak, Angeles Duran, Sang Jun Lee, Ronald Pratt, Ashley Wellendorf, Sarah Hill, Marcus Watkins, Roberto Civitelli, Daniel T Starczynowski, Maria T Diaz-Meco, Jorge Moscat, Jose A Cancelas. Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche. ASH Annual Meeting, ORAL PRESENTATION, 2014.
2. Chang KH, Nayak R, Roy S, Perumbeti A, Ficker AM, Bezold K, Pirman M, Dunn SK, Starnes J, Loberg A, Zhou X, Inagami T, Zheng Y, Malik P, Cancelas J.. Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation. Midwest Blood Club Symposium, ORAL PRESENTATION, 2013.
3. Chang KH*, Taniguchi Ishikawa E*, Olsson HA, Nayak RC, Ficker A, Dunn SK, Sengupta A, Whitsett J, Grimes HL, Cancelas JA. Kruppel-Like-Factor 5 (Klf-5) controls hematopoietic stem cell/progenitor bone marrow homing and lodging through Rab5-mediated expression of active β1 integrin. ASH Annual Meeting, ORAL PRESENTATION, 2012.
4. Chang KH, Nayak RC, Bezold K, Ficker A, Roy Swarnava R, Zhou X, Pirman M, Dunn S, Zheng Y, Malik P, Cancelas JA. Hyperangiotensinemia induces stem cell/progenitor mobilization and de-adhesion from BM endothelial cells through AT2R signaling and inhibition of RhoA activity. ASH Annual Meeting, Poster 3466, 2012.
5. Chang K, Bezold K, Ficker A, Madhu M, Pirman M, Arnett J, Dunn S, Malik P, Cancelas J. Loss of endothelial connexin-43 results in increased mobilization of hematopoietic stem cell and progenitors through angiotensin II/angiotensin II type-2 receptor signaling. International Society of Experimental Hematology, ORAL PRESENTATION, 2011.
6. Chang K, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu M, Ficker A, Santho R, Arnett J, Dunn S, Agirre X, Perentesis J, Deininger M, Bustelo X, Williams D, Cancelas J. Vav3 is required for p190-BCR-ABL-induced lymphoid progenitor transformation and leukemogenesis. ISEH Annual Meeting, ORAL PRESENTATION, 2011.
7. Chang KH, Bezold K, Madhu M, Ficker A, Pirman M, Arnett J, Dunn S, Malik P, Cancelas JA. Loss of endothelial connexin-43 results in increased mobilization of hematopoietic stem cell and progenitor through angiotensin II/angiotensin II type-2 receptor signaling. 9th Annual Midwest Blood Club Symposium, Abstract #40, 2011.
8. Chang KH, Sanchez-Aguilera A, Sengupta A, Santho R, Arnett J, Dunn S, Madhu M, Cancelas JA. Vav3 is essential for B-cell progenitor leukemogenesis induced by p190 BCR-ABL through modulation of BH3-only molecules. Midwest Blood Club Symposium, ORAL PRESENTATION, 2010.
9. Chang KH, Sanchez-Aguilera A, Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas JA. Activation of Rac2 and Vav3 are involved in p190 BCR-ABL induced B-cell acute lymphoblastic leukemia. 7th Midwest Blood Club Symposium, Abstract #26, 2009.
10. Chang K-H, Sanchez-Aguilera A, Sengupta A, Arnett J, Dunn S, Williams DA and Cancelas J.. Vav3 and Rac2 Activation Are Required for B Progenitor Transformation Induced by p190-BCR-ABL. Oral Presentation. ASH Annual Meeting, 2009.
11. Grant MB, Chang KH, Afzal A, Pan H, Mcfarland EL, Baxter LC, Shaw LC, Caballero S, Sengupta N, Li Calzi S, Sullivan SM, Chan-Ling T. Targeted gene expression of IGFBP-3 by hematopoietic stem cells and endothelial progenitor cells protects retina from vaso-obliteration and neovascularization in a rodent model of oxygen induced retinopathy. Endocrine Society 89th Annual Meeting, 2007.
12. Chang KH, Afzal A, McFarland EL, Baxter LC, Caballero S, Sengupta N, Li Calzi S, Sullivan SM, Chan-Ling T, Grant MB. IGFBP-3 regulates hematopoietic stem cells (HSC) and endothelial precursor cell differentiation, migration and retinal development. Assn Res Vision Ophthalmol, 2007.
13. Chang KH, Afzal A, Li Calzi S, Segal MS, Purich D, Grant MB. Nitric oxide (NO) and carbon monoxide (CO) regulates vasodilator-stimulated phosphoprotein (VASP), a key cytoskeletal protein involved in endothelial progenitor cell (EPC) migration. Assn Res Vision Ophthalmol, 2006.
14. Chang KH, Afzal A, Segal M, Caballero S, Segupta N, Grant MB. Endothelial progenitor cells (EPC) dysfunction in diabetic patients is due to decreased response to chemokine, stromal derived factor-1 (SDF-1). Assn Res Vision Ophthalmol, 2005.

Book Chapters

1. Hartmut Geiger, Heinrich Jasper, Maria Carolina Florian,Jose A. Cancelas, Kyung Hee Chang, et al. Chapter C(13): Aging of the Hematopoietic Stem Cell Niches. In: Stem Cell Aging: Mechanism, Consequences, Rejuvenation. 1. Springer-Verlag Wien: Verlag Wien, 245-256, 2015.
2. Heide Schatten, Ramesh C. Nayak, Kyung-Hee Chang, Jose A cancelas, et al. Chapter 3. Regulation of the Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease. In: The cytoskeleton in health and disease. Springer-Verlag New York: New York, 63-85, 2015.