Laila Khazai, MD

Peer-Reviewed Articles

1. Adrada BE, Moseley TW, Kapoor, MM, Scoggins ME, Patel MM, Perez F, Nia ES, Khazai L, Arribas , E, Rauch GM, Guirguis MS. Triple-Negative Breast Cancer: Histopathologic Features, Genomics, and Treatment. RadioGraphics 43(10):1-15, 2023. PMID: 37792593.
2. Yau C, Osdoit M, van der Noordaa M, Shad S, Wei J, de Croze D, Hamy AS, Laé M, Reyal F, Sonke GS, Steenbruggen TG, van Seijen M, Wesseling J, Martín M, Del Monte-Millán M, López-Tarruella S, I-SPY 2 Trial Consortium, Boughey JC, Goetz MP, Hoskin T, Gould R, Valero V, Edge SB, Abraham JE, Bartlett JMS, Caldas C, Dunn J, Earl H, Hayward L, Hiller L, Provenzano E, Sammut SJ, Thomas JS, Cameron D, Graham A, Hall P, Mackintosh L, Fan F, Godwin AK, Schwensen K, Sharma P, DeMichele AM, Cole K, Pusztai L, Kim MO, van 't Veer LJ, Esserman LJ, Symmans WF. Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients. Lancet Oncol 23(1):149-160, 2022. e-Pub 2021. PMID: 34902335.
3. Symmans WF, Yau C, Chen YY, Balassanian R, Klein ME, Pusztai L, Nanda R, Parker BA, Datnow B, Krings G, Wei S, Feldman MD, Duan X, Chen B, Sattar H, Khazai L, Zeck JC, Sams S, Mhawech-Fauceglia P, Rendi M, Sahoo S, Ocal IT, Fan F, LeBeau LG, Vinh T, Troxell ML, Chien AJ, Wallace AM, Forero-Torres A, Ellis E, Albain KS, Murthy RK, Boughey JC, Liu MC, Haley BB, Elias AD, Clark AS, Kemmer K, Isaacs C, Lang JE, Han HS, Edmiston K, Viscusi RK, Northfelt DW, Khan QJ, Leyland-Jones B, Venters SJ, Shad S, Matthews JB, Asare SM, Buxton M, Asare AL, Rugo HS, Schwab RB, Helsten T, Hylton NM, van 't Veer L, Perlmutter J, DeMichele AM, Yee D, Berry DA, Esserman LJ. Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial. JAMA Oncol. e-Pub 2021. PMID: 34529000.
4. Roy M, Teshome M, Damodaran S, Sahin AA, Khazai L, Arribas E, Candelaria RP, Scoggins ME, Lane DL, Giordano SH, Albarracin CT, Prieto VG, Nagarajan P. Male Mammary Paget Disease: A Tale of 2 Contrasting Cases. Am J Dermatopathol 42(12):981-985, 2020. PMID: 33289978.
5. Khalil MF, Taggart MW, Khazai L. Lamellated mucin concretions mimicking adenocarcinoma. Diagn Cytopathol 48(7):690-691, 2020. e-Pub 2020. PMID: 32294299.
6. Assi J, Khazai L. Synovial/Ganglion Cyst Involving the Sternoclavicular Joint. J Cytol 37(3):151-152, 2020. e-Pub 2020. PMID: 33088036.
7. Strang LR, Sun J, Sun W, Boulware D, Kiluk JV, Lee MC, Khazai L, Laronga C. Characteristics of Microinvasive Ductal Carcinoma In Situ Versus Noninvasive and Invasive Breast Cancer. J Surg Res 254:378-383. e-Pub 2020. PMID: 32535256.
8. Roy M, Huang ML, Khazai L. Breast amyloid presenting as calcifications. Breast J. e-Pub 2020. PMID: 32452093.
9. Lam CA, McGettigan MJ, Thompson ZJ, Khazal L, Chung CH, Centeno BA, McIver B, Valderrabano P.. Ultrasound characterization for thyroid nodules with indeterminate cytology: inter-observer agreement and impact of combining pattern-based and scoring-based classifications in risk stratification. Endocrine 66(2):278-287. e-Pub 2019. PMID: 31300961.
10. Nguyen L, Khazai L, Hakam A, Centeno BA, Rosa M. Diagnostic value of intraoperative rapid cytokeratin immunostain in the cytological evaluation of sentinel lymph nodes in patients with invasive lobular carcinoma. Diagn Cytopathol 47(5):482-487, 2019. e-Pub 2018. PMID: 30589516.
11. Agosto-Arroyo E, Tahmasbi M, Al Diffalha S, Khazai L, Xiong Y, Rosa M. Invasive Breast Carcinoma Tumor Size on Core Needle Biopsy: Analysis of Practice Patterns and Effect on Final Pathologic Tumor Stage. Clin Breast Cancer 18(5):e1027-e1030, 2018. e-Pub 2018. PMID: 29622383.
12. Khazai L, Agosto-Arroyo E, Rosa M. P40 Immunostain Does Not Outperform p63 as a Myoepithelial Cell Marker in the Daily Practice of Breast Pathology. Appl Immunohistochem Mol Morphol 26(8):599-604, 2018. PMID: 28549030.
13. Valderrabano P,Khazai L, Thompson ZJ, Otto KJ, Hallanger-Johnson JE, Chung CH, Centeno BA, McIver B. Association of Tumor Size With Histologic and Clinical Outcomes Among Patients With Cytologically Indeterminate Thyroid Nodules. JAMA Otolaryngol Head Neck Surg 144(9):788-795, 2018. PMID: 30027226.
14. Valderrabano P, Khazai L, Thompson ZJ, Leon ME, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Chung CH, Centeno BA, McIver B. Impact of oncogene panel results on surgical management of cytologically indeterminate thyroid nodules. Head Neck 40(8):1812-1823, 2018. e-Pub 2018. PMID: 29624786.
15. Valderrabano P, McGettigan MJ, Lam CA, Khazai L, Thompson ZJ, Chung CH, Centeno BA, McIver B. Thyroid Nodules with Indeterminate Cytology: Utility of the American Thyroid Association Sonographic Patterns for Cancer Risk Stratification. Thyroid 28(8):1004-1012, 2018. e-Pub 2018. PMID: 29848195.
16. Marshall C, Mounzer R, Hall M, Simon V, Centeno B, Dennis K, Dhillon J, Fan F, Khazai L, Klapman J, Komanduri S, Lin X, Lu D, Mehrotra S, Muthusamy VR, Nayar R, Paintal A, Rao J, Sams S, Shah J, Watson R, Rastogi A, Wani S. Suboptimal Agreement Among Cytopathologists in Diagnosis of Malignancy Based on Endoscopic Ultrasound Needle Aspirates of Solid Pancreatic Lesions: A Validation Study. Clin Gastroenterol Hepatol 16(7):1114-1122.e2, 2018. e-Pub 2017. PMID: 28911946.
17. Rosa M, Khazai L. Comparison of HER2 testing among laboratories: Our experience with review cases retested at Moffitt Cancer Center in a two-year period. Breast J 24(2):139-147, 2018. e-Pub 2017. PMID: 28703376.
18. Valderrabano P, Khazai L, Thompson ZJ, Sharpe SC, Tarasova VD, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Wenig BM, Chung CH, Centeno BA, McIver B. Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis. Thyroid 28(2):210-219, 2018. e-Pub 2017. PMID: 29160163.
19. Valderrabano P, Khazai L, Leon ME, Thompson ZJ, Ma Z, Chung CH, Hallanger-Johnson JE, Otto KJ, Rogers KD, Centeno BA, McIver B. Evaluation of ThyroSeq v2 performance in thyroid nodules with indeterminate cytology. Endocr Relat Cancer 24(3):127-136, 2017. e-Pub 2017. PMID: 28104680.
20. Agosto-Arroyo E, Rosa M, Chau A, Khazai L. Concurrent BRAF and PTEN mutations in melanoma of unknown origin presenting as a breast mass. SAGE Open Med Case Rep 5:2050313X17711064, 2017. e-Pub 2017. PMID: 28607685.
21. Al Diffalha S, Agosto-Arroyo E, Rosa M, Khazai L,. Symmetrical lipomatosis of tongue, misdiagnosed as primary amyloidosis. Human Path Case Reports, 2017.
22. Valderrabano P, Montilla-Soler J, Mifsud M, Leon M, Centeno B,Khazai L, Padhya T, McCaffrey T, Russell J, McIver B, Otto K. Hypermetabolism on (18)F-Fluorodeoxyglucose Positron Emission Tomography Scan Does Not Influence the Interpretation of Thyroid Cytopathology, and Nodules with a SUVmax <2.5 Are Not at Increased Risk for Malignancy. Thyroid 26(9):1300-7, 2016. e-Pub 2016. PMID: 27324615.
23. Khazai L, Falcon S, Rosa M. Metastatic Salivary Duct Carcinoma to the Breast. Breast J 22(4):461-3, 2016. e-Pub 2016. PMID: 27089239.
24. Khazai L, Chau A, Hoover S, Rosa M. Papillary endothelial hyperplasia arising in the irradiated breast: A diagnostic dilemma. Pathol Res Pract 212(7):604-7, 2016. e-Pub 2016. PMID: 27157404.
25. Valderrabano P, Leon ME, Centeno BA, Otto KJ, Khazai L, McCaffrey JC, Russell JS, McIver B. Institutional prevalence of malignancy of indeterminate thyroid cytology is necessary but insufficient to accurately interpret molecular marker tests. Eur J Endocrinol 174(5):621-9, 2016. e-Pub 2016. PMID: 26903551.
26. Patel BK, Jafarian N, Abbott AM, Khazai L, Lee MC. Imaging Findings and Management of Primary Breast Cancer in Accessory Axillary Breast Tissue. Clin Breast Cancer 15(4):e223-9, 2015. e-Pub 2015. PMID: 25986957.
27. Khazai L, Rosa M. Use of Immunohistochemical Stains in Epithelial Lesions of the Breast. Cancer Control 22(2):220-5, 2015. PMID: 26068768.
28. Khazai L, Middleton LP, Goktepe N, Liu BT, Sahin AA. Breast pathology second review identifies clinically significant discrepancies in over 10% of patients. J Surg Oncol 111(2):192-7, 2015. e-Pub 2014. PMID: 25273328.
29. Khazai L, Kundu UR, Jacob B, Patel S, Sneige N, Eapen GA, Morice RC, Caraway NP. Endobronchial ultrasound-guided transbronchial needle aspiration biopsy is useful evaluating mediastinal lymphadenopathy in a cancer center. Cytojournal 8:10, 2011. e-Pub 2011. PMID: 21712956.
30. Resetkova E, Khazai L, Albarracin CT, Arribas E. Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast. Breast J 16(6):573-80, 2010. PMID: 21070433.
31. Dimashkieh HH, Khazai L, Novak GD, Casey MB. Pathologic quiz case: an 83-year-old woman with a uterine cervical mass. Adenoid cystic carcinoma. Arch Pathol Lab Med 128(7):817-8, 2004. PMID: 15214839.
32. Khazai L, Grinberg G. Hepatocelluar carcinoma and fatigue in an otherwise healthy 89-year-old man. Contemporary Surgery, 2004.
33. Khazai L. Chronic diarrhea and weight loss in an elderly patient. Contemporary Surgery, 2004.

Abstracts

1. Ye Q, Klippel D, Albarracin C, Chen H, Contreras A, Ding Q, Huo L, Khazai L, Middleton L, Resetkova E, Sahin A, Sun H, Sweeney K, Symmans W, Wu Y, Krishnamurthy S. A Prospective Study of Real Time Whole Slide Imaging of Frozen Sections for Intraoperative Evaluation of Axillary Sentinel Lymph Nodes in Breast Cancer. Mod Pathol 104(3):S321-S322, 2024.
2. Thomas K, Khazai L, Gan Q. Angiosarcoma in Fluids: A Review of Cytologic Features in 22 Patients. Mod Pathol 104(3):S480-S482, 2024.
3. Qiong Gan1, Uma Kundu1, Deyali Chatterjee1, Savitri Krishnamurthy1, Mehran Taherian1, Haval Ali2, John Diks1, Joe Rodriguez1, Yuan Shen1, Laila Khazai1, Deepak Donthi1, Mariangela Gomez1, Sakshi Gupta1, Huamin Wang1. Distinction of Grade 3 Pancreatic Neuroendocrine Tumor versus Carcinoma using Cytomorphologic Assessment of FNA Material: Is It Doable and Does Experience Matter?. Mod Path 103(3, Supplement):S299-300, 2023.
4. Jodi M Carter, Molly E Klein, Sara J Venters, Kimmie Rabe, I Tolgay Ocal, Kamaljeet Singh, Denise M Wolf, Sunati Sahoo, Shuko Harada, Laila Khazai, Malini Harigopal, Alexander D Borowsky, Gregor Krings, Ronald Balassanian, Yunn-Yi Chen, Kimberley Cole, Sonal Shad, Amy Delson, Lamorna Brown-Swigart, I-SPY 2 TRIAL Consortium, Laura Esserman, Laura van ‘t Veer and W Fraser Symmans. Pathologic features of the inter-regimen biopsy predict response to neoadjuvant therapy in the I-SPY 2 TRIAL. 2020 San Antonio Breast Cancer Virtual Symposium 81(4):PS4-09, 2021.
5. Sara J Venters, Wen Li, Denise M Wolf, Jodi M Carter, Molly E Klein, Kamaljeet Singh, Kimmie Rabe, I Tolgay Ocal, David Newitt, Christina Yau, Natsuko Onishi, Jessica Gibbs, Sunati Sahoo, Shuko Harada, Laila Khazai, Malini Harigopal, Alexander D Borowsky, Gregor Krings, Ronald Balassanian, Yunn-Yi Chen, Kimberley Cole, Sonal Shad, Barbara LeStage, Amy Delson, Sandra Finestone, Lamorna Brown-Swigart, I-SPY 2 Imaging Working Group, I-SPY 2 TRIAL Consortium, Laura Esserman, Laura van ‘t Veer, W Fraser Symmans and Nola M Hylton. Serial MRI and pathology combined to select candidates for therapy de-escalation in the I-SPY 2 TRIAL. Cancer Res 81(4):PS4-10, 2021.
6. Natsuko Onishi, Wen Li, Sara J Venters, Denise M Wolf, David C Newitt, Elissa R Price, Jessica Gibbs, Barbara LeStage, the I-SPY 2 Pathology Working Group, the I-SPY 2 Imaging Working Group, the I-SPY 2 Consortium, William F Symmans and Nola M Hylton. Radiologic review to refine selection of candidates for de-escalation of neoadjuvant therapy. 2020 San Antonio Breast Cancer Virtual Symposium 81(4 Supplement):PS3-02, 2021.
7. Di Pasquale L, Khazai L, Xiong Y, Agosto-arroyo E. Impact of 2018 American Society of Clinical Oncology/College of American Pathologists Clinical Guidelines Update on HER-2 Oncogene Testing in Breast Cancer Cases. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2019.
8. Di Pasquale L, De Jesus J, Xiong Y, <b>Khazai L</b>, Agosto-arroyo, E, Rosa M.. Analysis of Concordance Between Radiologic Imaging Modalities, Final Pathologic Tumor Size and Focality in Invasive Breast Carcinoma. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2019.
9. Rosa M, Agosto-arroyo E, Hakam A, Centeno B, Mela N, Khazai L.. Diagnostic value of Intraoperative Rapid Cytokeratin Immunostain in the Cytological Evaluation of Sentinel Lymph Nodes in Patients with Invasive Lobular Carcinoma. Proceeding from American Society of Cytopathology (ASC), 2017.
10. Mounzer R, Marshall C, Hall M, SImon V, Centeno B, Dennis K, Dhillon J, Fan F, Khazai L, Klapman J, Komanduri S, Lu D, Mehrota S, Muthusamy V, Nayar R, Paintal A, Rao J, Sams S, SHah J, Tynan T, Watson R, Rastogi A, Wani S.. Predictors of interobserver variability (IOV) among cytopathologists evaluating ultrasound fine needle aspiration (EUS-FNA) cytology speaimens: Amulticenter validation study. Proceedings from Digestive Disease Week, 2017.
11. Wani S, Mounzer R, Hall M, Simon V, Centeno B, Dennis K, Dhillon J, fan F, Khazai L, Klapman J, Komanduri S, Lin X, Lu D, Mehrota S, Muthusamy V, Watson R, Rastogi A, Marshall C.. Suboptimal interobserver agreement (IOA) AMong cytopathologists for pancreatic endoscopic ultrasound fine needle aspiration (EUS-FNA) cytology specimens. Proceedings from Digestive Disease Week, 2017.
12. Khazai L, Dhillon J.. Utility and Reliability of Cell Block Sections in Predicting HPV status on metastatic HNSCC to Neck Nodes. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2017.
13. Dominguez C, Xiong Y, Khazai L, Rosa M, Agosto-Arroyo E.. Accurate assessment of tumor size in breast cancer patients: Comparison of different radiological modalities with final pathology. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2017.
14. Valderrabano P, Khazai L, Leon M, Thompson Z, Ma Z, Otto K, Rogers K, Centeno B, McIver B.. Impact of NIFTP reclassification on THYROSEQ V2 performance: A single center independent validation study. Proceedings from American Thyroid Association (ATA), 2016.
15. Agosto-Arroyo E, Xiong Y,<b> Khazai L</b>, Rosa M.. Correlation of Intraoperative, Macroscopic and Final Pathologic Tumor Size Measurement in Breast Cancer Patients. Proceedings from College of American Pathologists (CAP), 2016.
16. Agosto-Arroyo E, Rosa M, Chau A, Khazai, L.. The Great Mimicker: Metastatic melanoma presenting as breast mass without a cutaneous lesion. Proceedings from College of American Pathologists (CAP), 2016.
17. Agosto-Arroyo E, Rosa, M, Drukteinis, J, Khazai, L. Chondroid lesions of the breast on minimally invasive procedures- diagnostic challenges. Proceedings from College of American Pathologists (CAP), 2016.
18. Tahmasbi M, Al Diffalha S, Agosto-Arroyo E, Khazai L, Rosa M.. Impact of core needle biopsy tumor size on final pathologic tumor staging in breast carcinomas. Proceedings from College of American Pathologists (CAP), 2016.
19. Valderrabano P, Otto K, McCaffrey J, Leon M, Khazai L, Centeno B, McIver B.. The impact of molecular marker test results on surgical management of cytologically indeterminate thyroid nodules. Proceedings from International Thyroid Congress, 2015.
20. Abbott AM, Jafarian N, Patel B, Khazai L, Lee CM.. Management of primary breast cancer in accessory breast tissue. Proceedings from Annual Miami Breast Cancer Conference, 2015.
21. Rosa M, Magliocco A. Khazai L.. Benefits of a second opinion in breast pathology. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2014.
22. Shah S, Rosa M, Khazai L. Microglandular adenosis; a diagnostic pitfall. Proceedings from Florida Society of Pathologists (FSP), 2014.
23. Rosa M, Khazai L, Bui M.. Intraoperative imprint cytology evaluation of sentinel lymph nodes in breast carcinoma. Proceedings from American Association of Cytopathology, 2013.
24. Khazai L, Middleton L, Sahin A.. “Breast pathology review identifies clinically significant discrepancies in 10% of cases. Proceedings from United States and Canadian Society of Pathologists (USCAP), 2012.
25. Valderrabano P, Leon M, Khazai L, Centeno B, McIver B.. Subclassification of indeterminate categories of thyroid cytopathology improves risk stratification and could be used to select and interpret the results of molecular marker tests. Proceedings from International Thyroid Congress, 2010.
26. Yoon E, Salem A, Chen H, Albarracin C, Wu Y, Sneige N, Khazai L, Ding Q, Tang Z, Sahin A,. Correlation amongst Immunohistochemical (IHC) Scores, Fluorescence In Situ Hybridization (FISH) Groups and Final HER2 Status on Breast carcinoma (BC) and Quality Issues Surrounding Indeterminate FISH Tests: A Single Center Experience.