Lawrence Bronk, PHD

Peer-Reviewed Articles

1. Tang, J, Liu, D, Mathew, J, Campelo, S, Bronk, LF, Taylor, PA, Li, Y, Guan, F. Experimental design and control methods for dose rate optimization in a synchrotron-based proton therapy beamline. Precision Radiation Oncology 9(4):234-241, 2025. e-Pub 2025.
2. Poplaski, V, Patel, TD, Nguyen-Phuc, H, Kambal, A, Bronk, LF, Estes, MK, Coarfa, C, Blutt, SE. Distinct molecular responses of human intestinal organoids to proton and photon radiation. American Journal of Physiology - Gastrointestinal and Liver Physiology 329(6):G734-G746, 2025. e-Pub 2025. PMID: 41165566.
3. Thomas, R, Zhang, D, Cronkite, CA, Thomas, R, Singh, S, Bronk, LF, Morales, R, Duman, J, Grosshans, DR. Subcellular functions of tau mediate repair response and synaptic homeostasis in injury. Molecular psychiatry 30(10):4460-4472, 2025. e-Pub 2025. PMID: 40269186.
4. Bordieri, G, Missiaggia, M, Cartechini, G, Battestini, M, Bronk, LF, Guan, F, Grosshans, DR, Rai, P, Scifoni, E, La Tessa, C, Lattanzi, G, Cordoni, FG. Validation of the generalized stochastic microdosimetric model (GSM 2 ) over a broad range of LET and particle beam type. Physics in medicine and biology 70(1), 2025. e-Pub 2025. PMID: 39662041.
5. Flint, DB, Bright, SJ, McFadden, CH, Konishi, T, Martinus, DK, Manandhar, M, Ben Kacem, M, Bronk, LF, Sawakuchi, GO. An empirical model of carbon-ion relative biological effectiveness based on the linear correlation between radiosensitivity to photons and carbon ions. Physics in medicine and biology 69(24), 2024. e-Pub 2024. PMID: 39530708.
6. Guan, F, Bronk, LF, Kerr, M, Li, Y, Braby, LA, Sobieski, M, Wang, X, Zhang, X, Stephan, C, Grosshans, DR, Mohan, R. Interpreting the biological effects of protons as a function of physical quantity. Scientific reports 14(1), 2024. e-Pub 2024. PMID: 39448656.
7. Guan, F, Jiang, D, Wang, X, Yang, M, Iga, K, Li, Y, Bronk, LF, Bronk, JK, Wang, L, Guo, Y, Sahoo, N, Grosshans, DR, Koong, A, Zhu, XR, Mohan, R. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform. Precision Radiation Oncology 8(4):168-181, 2024. e-Pub 2024. PMID: 40337456.

Invited Articles

1. Zhang D, Zhou W, Lam TT, Weng C, Bronk L, Ma D, Wang Q, Duman JG, Dougherty PM, Grosshans DR. Radiation induces age-dependent deficits in cortical synaptic plasticity. Neuro Oncol 20(19):1207-1214, 2018. e-Pub 2018.

Review Articles

1. Yan, Y, Alexander, DA, Bednarz, B, Bronk, LF, Chen, H, Gladstone, DJ, Han, B, Iannuzzi, C, Li, Y, Nguyen, N, Mulenga, N, Viscariello, N, Wang, Y, Weygand, J, Zlateva, Y, Guan, F. Innovative approaches in precision radiation oncology. Frontiers in Medicine 12, 2025. e-Pub 2025. PMID: 41244760.
2. Yang, Z, Guan, F, Bronk, LF, Zhao, L. Multi-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy. Pharmacology and Therapeutics 254, 2024. e-Pub 2024. PMID: 38286161.
3. McNerlin C, Guan F, Bronk L, Lei K, Grosshans D, Young DW, Gaber MW. Maletic-Savatic M. Targeting hippocampal neurogenesis to protect astronauts' cognition and mood from decline due to space radiation effects. Life Sci Space Res (Amst) 35:170 - 179, 2022. e-Pub 2022.
4. Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst) 35:105 - 112, 2022. e-Pub 2022.
5. Tang TT, Zawaski JA, Kesler S, Beamish CA, Inoue T, Perez EC, Bronk L, Poenisch F, Briere TM, Sabek OM, Grosshans DR, Waleed Gaber M. Cognitive and imaging differences after proton and photon whole brain irradiation in a preclinical model. Int J Radiat Oncol Biol Phys, 2021. e-Pub 2021.
6. Wu RY, Liu AY, Yang J, Williamson TD, Wisdom PG, Bronk L, Gao S, Grosshan DR, Fuller DC, Gunn GB, Ronald Zhu X, Frank SJ. Evaluation of the accuracy of deformable image registration on MRI with a physical phantom. J Appl Clin Med Phys 1:166 - 173, 2020. e-Pub 2020.
7. Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):3199, 2020. e-Pub 2020.
8. Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jakel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers (Basel) 12:12, 2020. e-Pub 2020.
9. Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. Int J Radiat Oncol Biol Phys, 2019. e-Pub 2019.
10. Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO. Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death. Int J Radiat Oncol Biol Phys 105(5):1119 - 1125, 2019. e-Pub 2019.
11. Guan F, Geng C, Carlson DJ, Ma DH, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Phys med Biol 64(1), 2018. e-Pub 2018.
12. Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Phys Med 51:13-21, 2018. e-Pub 2018.
13. Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of (3) He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness". Med Phys 45(3):1301, 2018. e-Pub 2018.
14. Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans D, Mohan R. RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies. Int J Part Ther 5(1):160 - 171, 2018. e-Pub 2018.
15. Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncol 56(11):1367 - 1373, 2017. e-Pub 2017.
16. Abolfath R, Peeler CR, Newpower M, Bronk L, Grosshans D, Mohan R. A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data. Sci Rep 7(1):8340, 2017. e-Pub 2017.
17. Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmuller C, Jakel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Med Phys 44(11):6061-6073, 2017. e-Pub 2017.
18. Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of (3)He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761 - 776, 2016. e-Pub 2016.
19. Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of (3) He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness". Med. Phys 43(2):761-776, 2016. e-Pub 2016.
20. Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code". Med Phys 42(11):6234 - 6247, 2015. e-Pub 2015.
21. Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015.
22. Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 2015(42):6234 - 6247, 2015. e-Pub 2015.
23. Polf JC, Bronk LF, Driessen WH, Arap W, Pasqualini R, Gillin M. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles. Appl Phys Lett 98(19):193702, 2011. e-Pub 2011.
24. Cardo-Vila M, Giordano RJ, Sidman RL, Bronk LF, Fan Z, Mendelsohn J, Arap W, Pasqualini R. From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway. Proceedings of the National Academy of Sciences of the United States of America 107(11):5118 - 5123, 2010. e-Pub 2010.
25. Souza GR, Molina JR, Raphael RM, Ozawa MG, Stark DJ, Levin CS, Bronk LF, Ananta JS, Mandelin J, Georgescu MM, Bankson JA, Gelovani JG, Killian TC, Arap W, Pasqualini R. Three-dimensional tissue culture based on magnetic cell levitation. Nat Nanotechnol 5(4):291 - 296, 2010. e-Pub 2010.
26. Driessen WH, Bronk LF, Edwards JK, Proneth B, Souza GR, Decuzzi P, Pasqualini R, Arap W. On the synergistic effects of ligand-mediated and phage-intrinsic properties during in vivo selection. Adv Genet 69:115-133, 2010. e-Pub 2010.

Other Articles

1. Yan, Y, Alexander, DA, Bednarz, B, Bronk, LF, Chen, H, Gladstone, DJ, Han, B, Iannuzzi, C, Li, Y, Nguyen, N, Mulenga, N, Viscariello, N, Wang, Y, Weygand, J, Zlateva, Y, Guan, F Correction. Frontiers in Medicine 12, 2025. PMID: 41377801.
2. Yang Z, Guan F, Bronk L, Zhao L Integrating multiomic biomarkers to predict the response of esophageal cancer to neoadjuvant chemoradiotherapy: current status and future directions. Theranostics.
3. Stecklein SR, Larson RA, Bronk L, Rahal OM, Woodward WA HMG-CoA Reductase Inhibition Abrogates Homologous and Non-Homologous DNA Double-Strand Break Repair and Inhibits G1-to-S Transition in Inflammatory Breast Cancer Cells. Int J Radiat Oncol Biol Phys.
4. Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code". Med Phys 45(3):1302, 2018.

Editorials

1. Guan, F, Campelo, S, Jiang, Z, Bronk, LF. Editorial. Precision Radiation Oncology 9(4):232-233, 2025. PMID: 41477291.

Abstracts

1. Bronk L, Singh S, Bronk J, Liu K, Guan F, Mohan R, Koong A, Lang F, Schueler E, Grosshans D. The Effects of FLASH Radiation In An Advanced Model Of Normal Human Brain Tissue. AAPM 65th Annual meeting and exhibition.
2. Parkitny L, Osenberg S, Bronk L, Lagrone A, Guan F, Gaber MW, Grosshans D, Maletic-Savatic M. Low-dose radiation impairs neurogenesis in human forebrain organoids. Society for Neuroscience 50th Annual Meeting.
3. Wu R, Ding Y, Castillo P, Pham M, Williamsom T, Bronk L, Liu A, Fuller C, Yang J. MO-IePD-TRACK 3-06 Evaluation of Registration Accuracy for Online MR-Guided Adaptive Planning. AAPM 63rd Annual meeting and exhibition.
4. Bronk L, Bronk J, Singh S, Wang X, Jiang D, Guan F, Koong A, Mohan R, Lang F, Grosshans D. Human-Induced Pluripotent Stem Cell Derived Cerebral Organoids as a Model of Normal Brain Tissue Response to Proton Radiation. 103rd Annual Meeting of American Radium Society.
5. Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu XR, Schueler E, Jiang D, Mohan R, Koong A, Lang F, Grosshans D. Expanding the Therapeutic Window with Ultra-high Dose Rate Proton Radiation (FLASH-RT) in a Human Cerebral Organoid Based Allogeneic Brain Tumor Model. 04th Annual Meeting of American Radium Society.
6. Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu XR, Schueler E, Jiang D, Mohan R, Koong A, Lang F, Grosshans D. Enhanced radiation-sparing effects of ultra-high dose rate proton radiation (FLASH-RT) in a human induced pluripotent stem cell-derived cerebral organoid model. ASTRO 64th Annual Meeting.