Lee Wiederhold, MD, PhD
Department of Radiation Oncology, Division of Radiation Oncology
About Dr. Lee Wiederhold
Dr. Wiederhold’s subspecialty focus is head and neck cancer.
Dr. Wiederhold graduated from the UTMB Medical Scientist Training Program with his MD and PhD degrees in 2005. He served his transitional year at the University of Texas Health Science Center at Houston from 2005 to 2006, and completed his residency in Radiation Oncology at UTMB in 2010. He was Chief Resident for his final year, 2009 to 2010.
Present Title & Affiliation
Primary Appointment
Associate Professor, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Residency Program Director, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Radiation Oncology, University of Texas Medical Branch, Galveston, TX
Education & Training
Degree-Granting Education
| 2005 | University of Texas Medical Branch, Galveston, Texas, US, MD |
| 2005 | University of Texas Medical Branch, Galveston, Texas, US, Medicine, Ph.D |
| 1996 | Texas A&M University, College Station, Texas, US, Biochemistry, BS |
Postgraduate Training
| 2006-2010 | Clinical Residency, Radiation Oncology, University of Texas Medical Branch, Galveston, Texas |
| 2005-2006 | Clinical Internship, University of Texas Health Science Center at Houston, Houston, Texas |
Licenses & Certifications
| 2021 | DEA |
| 2011 | American Board of Radiology |
| 2007 | Texas Medical License |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2010 - 2015
Administrative Appointments/Responsibilities
Residency Program Director, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2015 - Present
Clinical Medical Director, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2011 - 2018
Residency Program Associate Director, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2011 - 2015
Chief of TDCJ Rad Onc Service, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2010 - Present
Chief of Head and Neck Service, Radiation Oncology, The University of Texas Medical Branch, Galveston, TX, 2010 - Present
Extramural Institutional Committee Activities
Chair, UTMB Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, UTMB Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2020
Member, UTMB MD-PhD Admissions Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2020
Member, UTMB MD-PhD Program Director Search Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2018
Core Service Specialites representative, UTMB Faculty Group Practice, The University of Texas MD Anderson Cancer Center, 2015 - 2016
Member, UTMB Radiation Protocol Committee for FGI, The University of Texas MD Anderson Cancer Center, 2014 - 2018
Member, UTMB Radiation Protocol Committee for Computed Tomography, The University of Texas MD Anderson Cancer Center, 2013 - 2018
Radiation Oncology Member, UTMB Quality of Care Committee, The University of Texas MD Anderson Cancer Center, 2013 - 2018
Member, UTMB LCME Education Subcommittee, The University of Texas MD Anderson Cancer Center, 2013 - 2014
Member, UTMB Cancer Care Committee, The University of Texas MD Anderson Cancer Center, 2012 - 2018
Honors & Awards
| 2017 | Texas Super Doctors Rising Stars |
| 2016 | Texas Super Doctors Rising Stars |
| 2011 - 2012 | ARRO Educator of the Year, ARRO |
| 2004 | UTMB Blocker Research Scholar, UTMB |
| 2002 - 2003 | Pre-doctoral toxicology fellow, NIEHS T32 ES07254-10 |
Professional Memberships
Selected Presentations & Talks
Regional Presentations
- 2012. “Radiation Oncology Coding” Galveston 2012 Coding Symposium. Conference. The University of Texas Medical Branch. Galveston, TX, US.
Selected Publications
Peer-Reviewed Articles
- Frank, SJ, Busse, PM, Lee, JJ, Rosenthal, D, Hernandez, M, Swanson, DM, Garden, AS, Gunn, GB, Patel, SH, Snider, JW, Ma, DJ, Molitoris, JK, Lee, N, Parvathaneni, U, McDonald, MW, Kalman, NS, Lin, A, Mohammed, N, Henson, CE, Hyde, C, Bajaj, GK, Katz, SR, Dagan, R, Morrison, WH, Reddy, JP, Fuller, C, Shah, SJ, Phan, J, Chronowski, G, Mayo, LL, Sturgis, EM, Ferrarotto, R, Zhu, XR, Zhang, X, Wang, L, Hutcheson, KA, El-Naggar, AK, Moreno, AC, Lee, A, Spiotto, MT, Gross, N, Lai, SY, Liao, JJ, Paly, JJ, Liao, Z, Foote, RL, Bates, JE, Chambers, MS, Chun, SG, Kaiser, A, Lester, SC, Lukens, JN, McGee, LA, Neben-Wittich, MA, Nguyen, Q, Routman, DM, Schlembach, PJ, Skinner, H, Soike, MH, Rwigema, JM, Wiederhold, LR, Blanchard, P, Choi, I, Koong, A, Langendijk, H, Mohan, R, Carlson, BJ, Mapps, A, Sarmiento, JG, Teferra, MY, Bosch, WR, Followill, DS, Taylor, PA, Fuentes, SY, Ning, M, Toumazis, I, Wogan, CF, De Gracia, B, Fink, K, Grippin, A, Ma, J, Pettersen, EA, Sareyeldin, RM, Cronin, C, Muise, S, Johnson, M, Pyfferoen, K, Tranby, BN, Leonard, J, Watkin, S, Eggleston, C, Barrow, B, Wolcott, J, Antonio, J, Brand, J, Cleverdon, A, Drake, M, Peters, E, Small, C, Clark, K, Holder, R. Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA. The Lancet 407(10524):174-184, 2026. e-Pub 2026. PMID: 41391462.
- Tino, R, Roach, MA, Fuentes, GD, Agrawal, A, Zaid, M, Cooper, DJ, Bajaj, N, Lin, R, Xiao, L, Mayo, LL, Wiederhold, LR, Shah, SJ, Tate, MK, Chronowski, G, Reddy, JP, Mezera, M, Mann, JM, Augspurger, ME, Otun, AO, Chambers, MS, Koay, EJ. Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy. Oral Oncology 157, 2024. e-Pub 2024. PMID: 39024700.
- Garg, AK, Hernandez, M, Schlembach, PJ, Bowers, JR, McAleer, MF, Brown, P, Gopal, R, Wiederhold, LR, Swanson, T, Shah, SJ, Li, J, Ferguson, SD, Philip, NV, Degracia, L, Bloom, ES, Chun, SG. A phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases. JNCI Cancer Spectrum 7(6), 2023. e-Pub 2023. PMID: 37944053.
- Corrigan KL, Lei X, Ahmad N, Arzu I, Bloom E, Chun SG, Goodman C, Hoffman KE, Joyner M, Mayo L, Mitchell M, Nead KT, Perkins GH, Reed V, Reddy JP, Schlembach P, Shaitelman SF, Stauder MC, Strom EA, Tereffe W, Wiederhold L, Woodward WA, Smith BD. Adoption of Ultrahypofractionated Radiation Therapy in Patients With Breast Cancer. Adv Radiat Oncol 7(2):100877, 2022. e-Pub 2022. PMID: 35387420.
- Lewis GD, Hatch SS, Wiederhold LR, Swanson TA. Long-Term Institutional Experience with Telemedicine Services for Radiation Oncology: A Potential Model for Long-Term Utilization. Adv Radiat Oncol 5(4):780-782, 2020. e-Pub 2020. PMID: 32391444.
- Polamraju P, Haque W, Verma V, Wiederhold L, Hatch S, Butler EB, Teh BS. Adjuvant management of pathologic node-positive disease after definitive surgery for clinical T1-2 N0 rectal cancer. Clin Colorectal Cancer 17(3):e519-e530, 2018. e-Pub 2018. PMID: 29753642.
- Haque W, Kee Yuan DM, Verma V, Butler EB, Teh BS, Wiederhold L, Hatch S. Radiation therapy utilization and outcomes for older women with breast cancer: Impact of molecular subtype and tumor grade. Breast 35:34-41, 2017. e-Pub 2017. PMID: 28646722.
- Patel SC, Paulino AC, Johnston D, Wiederhold L, Castillo R, Venkatramani R. Gemcitabine-induced radiation recall myositis in a patient with relapsed nasopharyngeal carcinoma. Pract Radiat Oncol 1(1):e19-e22, 2017. e-Pub 2017. PMID: 27637134.
- Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair (Amst) 5(12):1439-48, 2006. e-Pub 2006. PMID: 16982218.
- Chattopadhyay R, Wiederhold L, Szczesny B, Boldogh I, Hazra TK, Izumi T, Mitra S. Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Res 34(7):2067-76, 2006. e-Pub 2006. PMID: 16617147.
- Mokkapati SK, Wiederhold L, Hazra TK, Mitra S. Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases. Biochemistry 43(36):11596-604, 2004. e-Pub 2004. PMID: 15350146.
- Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK. AP endonuclease-independent DNA base excision repair in human cells. Mol Cell 15(2):209-20, 2004. e-Pub 2004. PMID: 15260972.
Review Articles
- Tann AW, Hatch SS, Joyner MM, Wiederhold LR, Swanson TA. Accelerated partial breast irradiation: Past, present, and future. World J Clin Oncol 7(5):370-379, 2016. e-Pub 2016. PMID: 27777879.
- Izumi T, Wiederhold LR, Roy G, Roy R, Jaiswal A, Bhakat KK, Mitra S, Hazra TK. Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology 193(1-2):43-65, 2003. e-Pub 2003. PMID: 14599767.
Abstracts
- Akhtari A, Batra A, Verma V, Wiederhold L. Resident supervision in contouring, treatment planning, and plan evaluation: a nationwide survey of Radiation Oncology residents. ASTRO 98(25):E11, 2017. e-Pub 2017.
- Cox JA, Sturgeon JD, Endres EC, Layer LA, Haque WM, Swanson TA, Parker BC, Colman M, Wiederhold LR. “Scalp sparing whole brain radiation therapy: Is IMRT and IGRT required?. 94th Annual Meeting of the American Radium Society, 2012. e-Pub 2012.
- Cox JA, Sturgeon JD, Endres EC, Swanson TA, Wiederhold LR. “Comparison of carotid sparing radiation treatment approaches for early laryngeal cancers: VMAT vs. IMRT”. ASTRO/ASCO 2012 Multidisciplinary Head and Neck Cancer Symposium, 2012. e-Pub 2012.
- Wiederhold LR, Wolski MJ, Brack CD, Puccetti ME, Lidstone KC, Morrill SM, Hatch SS, Colman M. Hurricane Preparations and Recovery-Lessons For Radiation Oncology From Hurricane Ike. American Radium Society (ARS) 93rd Meeting 25, 2011. e-Pub 2011.
- Wolski MJ, Eldaya R, Swanson T, Sturgeon J, Weiderhold L, Colman M. Single Institution Outcomes of Definitive Prostate Cancer Radiation Therapy with Five Year Follow-up. American College of Radiation Oncology (ACRO) Annual Meeting, 2011. e-Pub 2011.
Book Chapters
- Wiederhold L. Radiation of Head and Neck Cancers. In: Crush Otolaryngology Boards. Nova Science Publishers, 2019.
- Mitra, S, Wiederhold, L R, Dou, H, Izumi, T, Hazra, T K. New Paradigms for DNA Base Excision Repair in Mammals. In: DNA Damage Recognition. CRC Press, 2005.
Letters to the Editor
- Tino, R, Roach, MA, Fuentes, GD, Agrawal, A, Zaid, M, Cooper, DJ, Bajaj, N, Lin, R, Xiao, L, Mayo, LL, Wiederhold, LR, Shah, SJ, Tate, MK, Chronowski, G, Reddy, JP, Mezera, M, Mann, JM, Augspurger, ME, Otun, AO, Chambers, MS, Lee, A, Koay, EJ. Response to recent comments on “Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy”. Oral Oncology 162, 2025.
Patient Reviews
CV information above last modified July 22, 2026