Linda Fabris, Ph.D., M.S., B.A.
Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine Div
Education & Training
Degree-Granting Education
| 2011 | University of Udine, Udine, ITA, PHD, Medical and Biotechnological Sciences (Oncology) |
| 2007 | University of Trieste, Trieste, ITA, MS, Medical Biotechnology |
| 2005 | University of Trieste, Trieste, ITA, BA, Biotechnology |
Postgraduate Training
| 2014-2018 | Research Fellowship, Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2011-2014 | Research Fellowship, CRO National Cancer Institute, Aviano |
| 2005-2005 | Research Internship, ICGEB, Trieste |
Experience & Service
Academic Appointments
Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2020
Honors & Awards
| 2017 | The Harold C. and Mary L. Daily Endowed Fellowship Award, The University of Texas MD Anderson Cancer Center |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res 28(4):432-447, 2018. e-Pub 2018. PMID: 29567676.
- Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M. Publisher Correction: Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Nat Commun 9(1):160, 2018. e-Pub 2018. PMID: 29311577.
- Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs. Nat Commun 8(1):1801, 2017. e-Pub 2017. PMID: 29180617.
- Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafà R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol 18(1):98, 2017. e-Pub 2017. PMID: 28535802.
- Fabris L, Calin GA. Understanding the Genomic Ultraconservations: T-UCRs and Cancer. Int Rev Cell Mol Biol 333:159-172, 2017. e-Pub 2017. PMID: 28729024.
- Pellizzari I, Fabris L, Berton S, Segatto I, Citron F, D'Andrea S, Cusan M, Benevol S, Perin T, Massarut S, Canzonieri V, Schiappacassi M, Belletti B, Baldassarre G. p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms. Oncotarget 7(40):64560-64574, 2016. PMID: 27579539.
- Fabris L, Ceder Y, Chinnaiyan AM, Jenster GW, Sorensen KD, Tomlins S, Visakorpi T, Calin GA. The Potential of MicroRNAs as Prostate Cancer Biomarkers. Eur Urol 70(2):312-22, 2016. e-Pub 2016. PMID: 26806656.
- Paladini L, Fabris L, Bottai G, Raschioni C, Calin GA, Santarpia L. Targeting microRNAs as key modulators of tumor immune response. J Exp Clin Cancer Res 35:103, 2016. e-Pub 2016. PMID: 27349385.
- Fabris L, Calin GA. Circulating free xeno-microRNAs - The new kids on the block. Mol Oncol 10(3):503-8, 2016. e-Pub 2016. PMID: 26860056.
- Belletti B, Fabris L, Baldassarre G. p27kip1: An all-round tumor suppressor. Mol Cell Oncol 3(5):e1141742, 2016. e-Pub 2016. PMID: 28203637.
- Fabris L, Berton S, Pellizzari I, Segatto I, D'Andrea S, Armenia J, Bomben R, Schiappacassi M, Gattei V, Philips MR, Vecchione A, Belletti B, Baldassarre G. p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability. Proc Natl Acad Sci U S A 112(45):13916-21, 2015. e-Pub 2015. PMID: 26512117.
- De Marco C, Malanga D, Rinaldo N, De Vita F, Scrima M, Lovisa S, Fabris L, Carriero MV, Franco R, Rizzuto A, Baldassarre G, Viglietto G. Mutant AKT1-E17K is oncogenic in lung epithelial cells. Oncotarget 6(37):39634-50, 2015. PMID: 26053093.
- Segatto I, Berton S, Sonego M, Massarut S, Fabris L, Armenia J, Mileto M, Colombatti A, Vecchione A, Baldassarre G, Belletti B. p70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation. Mol Oncol 8(3):766-80, 2014. e-Pub 2014. PMID: 24661902.
- Armenia J, Fabris L, Lovat F, Berton S, Segatto I, D'Andrea S, Ivan C, Cascione L, Calin GA, Croce CM, Colombatti A, Vecchione A, Belletti B, Baldassarre G. Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. Oncotarget 5(5):1185-97, 2014. PMID: 24727437.
- Berton S, Pellizzari I, Fabris L, D'Andrea S, Segatto I, Canzonieri V, Marconi D, Schiappacassi M, Benevol S, Gattei V, Colombatti A, Belletti B, Baldassarre G. Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. Cell Cycle 13(19):3100-11, 2014. PMID: 25486569.
- Segatto I, Berton S, Sonego M, Massarut S, D'Andrea S, Perin T, Fabris L, Armenia J, Rampioni G, Lovisa S, Schiappacassi M, Colombatti A, Bristow RG, Vecchione A, Baldassarre G, Belletti B. Inhibition of breast cancer local relapse by targeting p70S6 kinase activity. J Mol Cell Biol 5(6):428-31, 2013. e-Pub 2013. PMID: 23899505.
- D'Andrea S, Berton S, Segatto I, Fabris L, Canzonieri V, Colombatti A, Vecchione A, Belletti B, Baldassarre G. Stathmin is dispensable for tumor onset in mice. PLoS One 7(9):e45561, 2012. e-Pub 2012. PMID: 23029098.
- Schiappacassi M, Lovisa S, Lovat F, Fabris L, Colombatti A, Belletti B, Baldassarre G. Role of T198 modification in the regulation of p27(Kip1) protein stability and function. PLoS One 6(3):e17673, 2011. e-Pub 2011. PMID: 21423803.
- Belletti B, Pellizzari I, Berton S, Fabris L, Wolf K, Lovat F, Schiappacassi M, D'Andrea S, Nicoloso MS, Lovisa S, Sonego M, Defilippi P, Vecchione A, Colombatti A, Friedl P, Baldassarre G. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol 30(9):2229-40, 2010. e-Pub 2010. PMID: 20194624.
Grant & Contract Support
| Title: | Acute Myeloid Leukemia in the Immunosuppressed Microenvironment - Project 2: Immunotherapy for AML Using Off-the-Shelf and Engineered Cord Blood-Derived Natural Killer Cells |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |