Linghua Wang, PhD
Department of Genomic Medicine, Division of Cancer Medicine
About Dr. Wang
Dr. Wang received her undergraduate degree in Clinical Medicine and PhD in Cancer Genomics. She completed her postdoctoral training at Human Genome Sequencing Center (HGSC), Baylor College of Medicine, where she became a faculty Instructor in 2014 and Research Assistant Professor in 2015. She has led genomic data analysis of multiple national and international large-scale cancer genomics projects at HGSC including the somatic and germline mutation discovery of a highly successful Rare Cancer Project, TCGA testicular germ cell tumor, NCI Exceptional Responders Initiative, TCGA Pan-cancer analysis of immune response in immunologically quite tumors and the DNA damage response/repair pathway. She has had a profound influence on cancer data analysis pipeline at HGSC and she has made key scientific discoveries in almost every cancer type in which she worked. Over the past several years, she has published over 15 peer-reviewed manuscripts on top scientific journals including Nature, Nature Genetics, Cell, Genome Research, Blood, and Leukemia. Dr. Wang was recently (March 2017) recruited to Department of Genomic Medicine, MD Anderson Cancer Center, as a Tenure-track Assistant Professor to continue her work to advance the scientific understanding and treatment of cancer. Dr. Wang's current primary interests are to conduct innovative translational research to identify genomic determinants of tumor response, resistance to chemo- and immunotherapies and treatment-related toxicities, to identify biomarkers and build prediction models to estimate the likelihood of clinical benefit and toxicity from anticancer therapies by high-dimensional multi-platform data integration.
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Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Bioinformatics and Computational Biology, Cancer Therapeutic Resistance and Toxicity, Cancer Genomics and Immunology, Tumor Heterogeneity and Evolution, Tumor Immune Microenvironment, Big Data Mining
Education & Training
Degree-Granting Education
| 2011 | The University of Tokyo, Tokyo, JPN, PHD, Cancer Genomics |
| 2006 | Sun Yat-Sen University, Guangzhou, CHN, MD, Ophthalmology |
| 2003 | Taishan Medical University, Taian, CHN, BS, Clinical Medicine |
Postgraduate Training
| 2012-2014 | Postdoctoral Associate, Cancer Genomics, Baylor College of Medicine, Houston, TX |
| 2011-2011 | Postdoctoral Fellow, Cancer Genomics, The University of Tokyo, Tokyo |
| 2007-2008 | Research Fellowship, Cancer Genetics, Nihon University School of Medicine, Tokyo |
Experience & Service
Academic Appointments
Assistant Professor, Baylor College of Medicine, Houston, TX, 2015 - 2017
Instructor, Baylor College of Medicine, Houston, TX, 2014 - 2015
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Shen H, Shih J, Hollern DP, *Wang L, Bowlby R, Tickoo SK, Thorsson V, Mungall AJ, Newton Y, Hegde AM, Armenia J, Sánchez-Vega F, Pluta J, Pyle LC, Mehra R, Reuter VE, Godoy G, Jones J, Shelley CS, Feldman DR, Vidal DO, Lessel D, Kulis T, Cárcano FM, Leraas KM, Lichtenberg TM, Brooks D, Cherniack AD, Cho J, Heiman DI, Kasaian K, Liu M, Noble MS, Xi L, Zhang H, Zhou W, ZenKlusen JC, Hutter CM, Felau I, Zhang J, Schultz N, Getz G, Meyerson M, Stuart JM, Cancer Genome Atlas Research Network, Akbani R, Wheeler DA, Laird PW, Nathanson KL, Cortessis VK, Hoadley KA. (*as co-first author). Integrated molecular characterization of testicular germ cell tumors. Cell Rep 23(11):3392-3406, 2018. PMID: 29898407.
- Knijnenburg TA, *Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I, Cancer Genome Atlas Research Network, Monnat RJ, Xiao Y, Wang C. (*as co-first author). Genomic and molecular landscape of DNA damage repair deficiency across The Cancer Genome Atlas. Cell Rep 23(1):239-254.e6, 2018. PMID: 29617664.
- TCGA-HCC group including *Wang L (*as co-first author). Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell 169(7):1327-1341.e23, 2017. PMID: 28622513.
- Lanikova L, Babosova O, Swierczek S, *Wang L, Wheeler DA, Divoky V, Korinek V, Prchal JT. Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera. Blood 128(18):2266-2270, 2016. e-Pub 2016. PMID: 27647865.
- Eckstein OS, *Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE.. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol 44(8):740-4, 2016. e-Pub 2016. PMID: 27208809.
- *Wang L, Ni X, Covington KR, Yang BY, Shiu J, Zhang X, Xi L, Meng Q, Langridge T, Drummond J, Donehower LA, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Duvic M. Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes. Nat Genet 47(12):1426-34, 2015. e-Pub 2015. PMID: 26551670.
- Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, Lim KP, Covington KR, Trevino L, Dewal N, Muzny DM, Doddapaneni H, Hu J, *Wang L, Lupo PJ, Hicks MJ, Bonilla DL, Dwyer KC, Berres ML, Poulikakos PI, Merad M, McClain KL, Wheeler DA, Allen CE, Parsons DW. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood 124(19):3007-15, 2014. e-Pub 2014. PMID: 25202140.
- *Wang L, Yamaguchi S, Burstein MD, Terashima K, Chang K, Ng HK, Nakamura H, He Z, Doddapaneni H, Lewis L, Wang M, Suzuki T, Nishikawa R, Natsume A, Terasaka S, Dauser R, Whitehead W, Adekunle A, Sun J, Qiao Y, Marth G, Muzny DM, Gibbs RA, Leal SM, Wheeler DA, Lau CC. Novel somatic and germline mutations in intracranial germ cell tumours. Nature 511(7508):241-5, 2014. e-Pub 2014. PMID: 24896186.
- *Wang L, Swierczek SI, Drummond J, Hickman K, Kim SJ, Walker K, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Prchal JT. Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes. Leukemia 28(4):935-8, 2014. e-Pub 2014. PMID: 24413320.
- *Wang L, Swierczek SI, Lanikova L, Kim SJ, Hickman K, Walker K, Wang K, Drummond J, Doddapaneni H, Reid JG, Muzny DM, Gibbs RA, Wheeler DA, Prchal JT. The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in polycythemia vera. Leukemia 28(4):938-41, 2014. e-Pub 2014. PMID: 24463469.
- *Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res 22(2):208-19, 2012. e-Pub 2011. PMID: 22156295.
- Goschzik T, Gessi M, Dreschmann V, Gebhardt U, *Wang L, Yamaguchi S, Wheeler DA, Lauriola L, Lau CC, Müller HL, Pietsch T. Genomic Alterations of Adamantinomatous and Papillary Craniopharyngioma. J Neuropathol Exp Neurol. e-Pub 2017. PMID: 28069929.
Invited Articles
- *Wang L, Wheeler DA, Prchal JT.. Acquired uniparental disomy of chromosome 9p in hematologic malignancies. Exp Hematol 44(8):644-52, 2016. e-Pub 2015. PMID: 26646991.
- *Wang L & Wheeler DA.. Genomic sequencing for cancer diagnosis and therapy. Annu Rev Med 65:33-48, 2014. e-Pub 2013. PMID: 24274147.
- Wheeler DA & *Wang L.. From human genome to cancer genome: the first decade. Genome Res 23(7):1054-62, 2013. PMID: 23817046.
- Aburatani H & *Wang L.. Integrated genomic analysis of pancreatic ductal carcinoma. Experimental Medicine 30:33-38, 2012.
Grant & Contract Support
| Title: | NCI Exceptional Responders (Subaward-Subcontract) |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Title: | Start-up funds for Tenure-Track Assistant Professor |
| Funding Source: | MDACC |
| Role: | Principal Investigator |
| Title: | B-Cell Lymphoma Moon Shot Program |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | High-Risk Multiple Myeloma Moon Shot Pilot Program |
| Funding Source: | The University of Texas M.D. Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | A biomarker-based, combination therapy with immune checkpoint blockade and pemetrexed for MTAP-deficient metastatic bladder cancer |
| Funding Source: | Doris Duke Charitable Foundation |
| Role: | Co-Investigator |