Lisa S. Chen, PhD
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2004 | Northwestern University, Evanston, IL, USA, PHD, Chemistry |
| 2002 | Northwestern University, Evanston, IL, USA, MS, Chemistry |
| 1999 | Tufts University, Medford, MA, USA, BS, Quantitative Economics and Chemistry |
Postgraduate Training
| 2004-2008 | Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Assistant Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2023
Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2010
Selected Publications
Peer-Reviewed Articles
- Pullarkat V*, Chen LS*, Palmer J, Zhang J, Synold TW, Buettner R, Truong Nguyen LX, Marcucci G, Tsai NC, Wang Y, O'Hearn J, Gandhi V, Rosen ST. A Phase 1 Trial of 8-Chloro-Adenosine in Relapsed/Refractory Acute Myeloid Leukemia: An Evaluation of Safety and Pharmacokinetics. Cancer 130(5):727-739, 2024. e-Pub 2023. PMID: 37897709.
- Aslan B, Kismali G, Iles LR, Manyam GC, Ayres ML, Chen LS, Gagea M, Bertilaccio MTS, Wierda WG, Gandhi V. Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia. Blood Cancer J 12(5):80, 2022. e-Pub 2022. PMID: 35595730.
- Hoang DH, Morales C, Rodriguez IR, Valerio M, Guo J, Chen MH, Wu X, Horne D, Gandhi V, Chen LS, Zhang B, Pullarkat V, Rosen ST, Marcucci G, Buettner R, Nguyen LXT. Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism. Cancers (Basel) 14(6), 2022. e-Pub 2022. PMID: 35326597.
- Teakell S, Chen LS, Stellrecht CM, Gandhi V. The Role of P53 and P21 on 8-Chloro-Adenosine-Induced Cellular Response. Nucleosides Nucleotides Nucleic Acids 41(12):1-16, 2022. e-Pub 2022. PMID: 35227162.
- Aslan B, Kismali G, Chen LS, Iles LR, Mahendra M, Peoples M, Gagea M, Fowlkes NW, Zheng X, Wang J, Vellano CP, Marszalek JR, Bertilaccio MTS, Gandhi V. Development and Characterization of Prototypes for In Vitro and In Vivo Mouse Models of Ibrutinib-Resistant CLL. Blood Adv 5(16):3134-3146, 2021. PMID: 34424317.
- Buettner R, Nguyen LXT, Morales C, Chen MH, Wu X, Chen LS, Hoang DH, Hernandez Vargas S, Pullarkat V, Gandhi V, Marcucci G, Rosen ST. Targeting the Metabolic Vulnerability of Acute Myeloid Leukemia Blasts with a Combination of Venetoclax and 8-Chloro-Adenosine. J Hematol Oncol 14(1):70, 2021. e-Pub 2021. PMID: 33902674.
- Groenland SL, Ratain MJ, Chen LS, Gandhi V. The Right Dose: From Phase I to Clinical Practice. Am Soc Clin Oncol Educ Book 41:92-106, 2021. PMID: 34010057.
- Chen LS, Keating MJ, Wierda WG, Gandhi V. Induction of Apoptosis by MCL-1 Inhibitors in Chronic Lymphocytic Leukemia Cells. Leuk Lymphoma 60(12):1-4, 2019. e-Pub 2019. PMID: 31161836.
- Buettner R, Nguyen LXT, Kumar B, Morales C, Liu C, Chen LS, Pemovska T, Synold TW, Palmer J, Thompson R, Li L, Hoang DH, Zhang B, Ghoda L, Kowolik C, Kontro M, Leitch C, Wennerberg K, Yu X, Chen CC, Horne D, Gandhi V, Pullarkat V, Marcucci G, Rosen ST. 8-Chloro-Adenosine Activity in FLT3-ITD Acute Myeloid Leukemia. J Cell Physiol 234(9):16295-16303. e-Pub 2019. PMID: 30770553.
- Chen LS, Bose P, Cruz ND, Jiang Y, Wu Q, Thompson PA, Feng S, Kroll MH, Qiao W, Huang X, Jain N, Wierda WG, Keating MJ, Gandhi V. A Pilot Study of Lower Doses of Ibrutinib in Patients with Chronic Lymphocytic Leukemia. Blood 132(21):2249-2259, 2018. e-Pub 2018. PMID: 30254130.
- Cortes J, Tamura K, DeAngelo DJ, de Bono J, Lorente D, Minden M, Uy GL, Kantarjian H, Chen LS, Gandhi V, Godin R, Keating K, McEachern K, Vishwanathan K, Pease JE, Dean E. Phase I Studies of AZD1208, a Proviral Integration Moloney Virus Kinase Inhibitor in Solid and Haematological Cancers. Br J Cancer 118(11):1425-1433, 2018. e-Pub 2018. PMID: 29765150.
- Stellrecht CM, Chen LS, Ayres ML, Dennison JB, Shentu S, Chen Y, Keating MJ, Wierda WG, Gandhi V. Chlorinated Adenosine Analogue Induces AMPK and Autophagy in Chronic Lymphocytic Leukemia Cells During Therapy. Br J Haematol 179(2):266-271, 2017. e-Pub 2017. PMID: 28737232.
- Yang Q, Chen LS, Ha MJ, Do KA, Neelapu SS, Gandhi V. Idelalisib Impacts Cell Growth Through Inhibiting Translation Regulatory Mechanisms in Mantle Cell Lymphoma. Clin Cancer Res 23(1):181-192, 2017. e-Pub 2016. PMID: 27342398.
- Chen LS, Yang JY, Liang H, Cortes JE, Gandhi V. Protein Profiling Identifies mTOR Pathway Modulation and Cytostatic Effects of Pim Kinase Inhibitor, AZD1208, in Acute Myeloid Leukemia. Leuk Lymphoma 57(12):1-11, 2016. e-Pub 2016. PMID: 27054578.
- Chen LS, Keating MJ, Gandhi V. Blood Collection Methods Affect Cellular Protein Integrity: Implications for Clinical Trial Biomarkers and ZAP-70 in CLL. Blood 124(7):1192-5, 2014. PMID: 25124785.
- Patel V, Chen LS, Wierda WG, Balakrishnan K, Gandhi V. Impact of Bone Marrow Stromal Cells on Bcl-2 Family Members in Chronic Lymphocytic Leukemia. Leuk Lymphoma 55(4):899-910, 2014. e-Pub 2013. PMID: 23837491.
- Yang Q, Chen LS, Neelapu SS, Gandhi V. Combination of Pim Kinase Inhibitor SGI-1776 and Bendamustine in B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk 13 Suppl 2:S355-62, 2013. PMID: 24290221.
- Cervantes-Gomez F, Chen LS, Orlowski RZ, Gandhi V. Biological Effects of the Pim Kinase Inhibitor, SGI-1776, in Multiple Myeloma. Clin Lymphoma Myeloma Leuk 13 Suppl 2:S317-29, 2013. e-Pub 2013. PMID: 23988451.
- Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ, Gandhi V. Transcription and Translation are Primary Targets of Pim Kinase Inhibitor, SGI-1776, in Mantle Cell Lymphoma. Blood 120(17):3491-500, 2012. e-Pub 2012. PMID: 22955922.
- Pillai RN, Chen LS, Ayres ML, Nowak BJ, Thomas MW, Shpall EJ, Keating MJ, Gandhi V. Multifaceted Actions of 8-Amino-Adenosine Kill BCR-ABL Positive Cells. Leuk Lymphoma 53(10):2024-32, 2012. e-Pub 2012. PMID: 22448923.
- Chen LS, Redkar S, Taverna P, Cortes JE, Gandhi V. Mechanisms of Cytotoxicity to Pim Kinase Inhibitor, SGI-1776, in Acute Myeloid Leukemia. Blood 118(3):693-702, 2011. e-Pub 2011. PMID: 21628411.
- Stellrecht CM, Chen LS. Transcription Inhibition as a Therapeutic Target for Cancer. Cancers (Basel) 3(4):4170-90, 2011. e-Pub 2011. PMID: 24213132.
- Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain Termination and Inhibition of Mammalian Poly(A) Polymerase by Modified ATP Analogues. Biochem Pharmacol 79(5):669-77, 2010. e-Pub 2009. PMID: 19814999.
- Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi V. Pim Kinase Inhibitor, SGI-1776, Induces Apoptosis in CLL Lymphocytes. Blood 114(19):4150-7, 2009. e-Pub 2009. PMID: 19734450.
- Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi V. Inhibition of ATP Synthase by Chlorinated Adenosine Analogue. Biochem Pharmacol 78(6):583-91, 2009. e-Pub 2009. PMID: 19477165.
- Chen LS, Plunkett W, Gandhi V. Polyadenylation Inhibition by the Triphosphates of Deoxyadenosine Analogues. Leuk Res 32(10):1573-81, 2008. e-Pub 2008. PMID: 18433867.
- Chen LS, Stellrecht CM, Gandhi V. RNA-Directed Agent, Cordycepin, Induces Cell Death in Multiple Myeloma Cells. Br J Haematol 140(6):682-391, 2008. e-Pub 2008. PMID: 18205859.
- Chen LS, Sheppard TL. Chain Termination and Inhibition of Saccharomyces Cerevisiae poly(A) Polymerase by C-8-Modified ATP Analogs. J Biol Chem 279(39):40405-11, 2004. e-Pub 2004. PMID: 15265873.
- Chen LS, Bahr MH, Sheppard TL. Effects of 8-Chlorodeoxyadenosine on DNA Synthesis by Klenow Fragment of DNA Polymerase. Bioorg Med Chem Lett 13(9):1509-12, 2003. PMID: 12699743.
- Chen LS, Sheppard TL. Synthesis and Hybridization Properties of RNA Containing 8-Chloroadenosine. Nucleosides Nucleotides Nucleic Acids 21(8-9):599-617, 2002. PMID: 12484453.
- Rybak-Akimova EV, Nazarenko AY, Chen L, Krieger PW, Herrera AM, Tarasov VV, Robinson PD. Synthesis, Characterization, Redox Properties, and Representative X-ray Structures of four-and five-Coordinate Copper(II) Complexes with Polydentate Aminopyridine Ligands. Inorg. Chim. Acta(324):1-15, 2001.
Invited Articles
- Chen LS, Balakrishnan K, Gandhi V. Inflammation and Survival Pathways: Chronic Lymphocytic Leukemia as a Model System. Biochem Pharmacol 80(12):1936-45, 2010. e-Pub 2010. PMID: 20696142.
Editorials
- Bose P, Chen LS, Gandhi V. Ibrutinib Dose and Clinical Outcome in Chronic Lymphocytic Leukemia - Learning from the 'Real World'. Leuk Lymphoma 60(7):1603-1605, 2019. PMID: 30724681.
- Gandhi V, Balakrishnan K, Chen LS. Mcl-1: the 1 in CLL. Blood 112(9):3538-40, 2008. PMID: 18948586.
Grant & Contract Support
| Title: | Novel RNA-Directed Therapy for the Treatment of Acute Myeloid Leukemia |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Targeting McI-1 in CLL |
| Funding Source: | CLL Global Research Foundation: U.S./European Alliance |
| Role: | Co-Investigator |
| Title: | A Combination Strategy to Target Pathophysiology of Chronic Lymphocytic Leukemia |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified June 17, 2024