Luigi Perelli, M.D., Ph.D.
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
2022 | Catholic University of the Sacred Heart, Rome, IT, PhD Oncological Sciences |
2018 | Catholic University of the Sacred Heart, Rome, IT, Medicine and Surgery |
Postgraduate Training
2024-null | Instructor, The University of Texas MD Anderson Cancer Center, Houston, Texas |
2022-2024 | Postgraduate Fellow, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Other Appointments/Responsibilities
Associate Member, American Association for Cancer Research (AACR)
Honors & Awards
2019 | “Ermenegildo Zegna Founder’s Scholarship” |
2018 | “Ermenegildo Zegna Founder’s Scholarship” |
PhD degree, Excellent cum laude | |
Medical Degree 110/110 |
Selected Publications
Other Articles
- Perelli L*#, Zhang L, Mangiameli S, Russell AJC, Giannese F, Peng F, Carbone F, Le C, Khan H, Citron F, Soeung M, Lam TNA, Lundgren S, Zhu C, Catania D, Feng N, Gurreri E, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Heffernan TP, Wang L, Cittaro D, Chen F, Genovese G Evolutionary fingerprints of EMT in pancreatic cancers. Nature None(None):None, 2023. PMID: 37786705.
- Perelli L*#, Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J, Jonasch E, Draetta GF, Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P, Litchfield K, Turajlic S, Wang L, Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP, Viale A, Bristow CA, Tannir NM, Carugo A, Genovese G Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nat Cancer None(None):None, 2023. PMID: 37365326.
- Gurreri E, Genovese G, Perelli L, Agostini A, Piro G, Carbone C, Tortora G KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy. Int J Mol Sci None(None):None, 2023. PMID: 37298264.
- Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A None(None):None, 2023. PMID: 37186844.
- Bezwada D, Perelli L, Lesner NP, Brooks B, Vu HS, Wu Z, Cai L, Kasitinon S, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, Sudderth J, Dumesnil D, House S, Rosales T, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Margulis V, DeBerardinis RJ Mitochondrial metabolism in primary and metastatic human kidney cancers. Nature None(None):None, 2023. PMID: 36798172.
- Shapiro, DD, Soeung, M, Perelli, L, Dondossola, E, Surasi, DS, Tripathi, DN, Bertocchio, J-P, Carbone, F, Starbuck, MW, Alstine V, ML, Rao, P, Katz, MHG, Parker, NH, Shah, AY, Carugo, A, Heffernan, TP, Schadler, KL, Logothetis, C, Walker, CL, Wood, CG, Karam, JA, Draetta, GF, Tannir, NM, Genovese, G, Msaouel, P Association of high-intensity exercise with renal medullary carcinoma in individuals with sickle cell trait: Clinical observations and experimental animal studies. None None(None):None, 2021. PMID: None.
- Tomihara, H*, Carbone, F*, Perelli, L*, Huang, JK, Soeung, M, Rose, JL, Robinson, FS, Deribe, YL, Feng, N, Takeda, M, Inoue, A, Poggetto, ED, Deem, AK, Maitra, A, Msaouel, P, Tannir, NM, Draetta, GF, Viale, A, Heffernan, TP, Bristow, CA, Carugo, A, Genovese, G Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress A C. Cancer Research None(None):None, 2021. PMID: None.
- Lucchetti, D, Santini, G, Perelli, L*, Ricciardi-Tenore, C, Colella, F, Mores, N, Macis, G, Bush, A, Sgambato, A, Montuschi, P Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients. European Respiratory Journal None(None):None, 2021. PMID: None.
- Msaouel, P, Malouf, GG, Su, X, Yao, H, Tripathi, DN, Soeung, M, Gao, J, Rao, P, Coarfa, C, Creighton, CJ, Bertocchio, J-P, Kunnimalaiyaan, S, Multani, AS, Blando, J, He, R, Shapiro, DD, Perelli, L, Srinivasan, S, Carbone, F, Pilié, PG, Karki, M, Seervai, RNH, Vokshi, BH, Lopez-Terrada, D, Cheng, EH, Tang, X, Lu, W, Wistuba, II, Thompson, TC, Davidson, I, Giuliani, V, Schlacher, K, Carugo, A, Heffernan, TP, Sharma, P, Karam, JA, Wood, CG, Walker, CL, Genovese, G, Tannir, NM Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell None(None):None, 2020. PMID: None.
- Lucchetti, D, Battaglia, A, Ricciardi-Tenore, C, Colella, F, Perelli, L*, Maria, RD, Scambia, G, Sgambato, A, Fattorossi, A Measuring extracellular vesicles by conventional flow cytometry: Dream or reality?. International Journal of Molecular Sciences None(None):None, 2020. PMID: None.
- Citron, F*, Perelli, L*, Deem, AK, Genovese, G, Viale, A Leukotrienes, a potential target for Covid-19. Prostaglandins Leukotrienes and Essential Fatty Acids None(None):None, 2020. PMID: None.
- Lucchetti, D, Perelli, L*, Colella, F, Ricciardi-Tenore, C, Scoarughi, GL, Barbato, G, Boninsegna, A, Maria D, R, Sgambato, A Low-intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial-to-mesenchymal transition of colorectal cancer cells. Journal of Cellular Physiology None(None):None, 2020. PMID: None.
- Lucchetti, D, Colella, F, Perelli, L, Ricciardi‐Tenore, C, Calapà, F, Fiori, ME, Carbone, F, Maria D, R, Sgambato, A CD147 promotes cell small extracellular vesicles release during colon cancer stem cells differentiation and triggers cellular changes in recipient cells. Cancers None(None):None, 2020. PMID: None.
- Soeung M, Yan X, Perelli L, Zanca C, Zhang L, Chen Z, Perelli L, Chen J, Tidwell R, Khan H, Le C, Lam T, Bhattacharya N, Shah R, Ho I, Gay J, Carrillo C, Feng N, Le K, Gao G, Perry T, Mseeh F, Jiang Y, Xu Q, Karki DM, Millward DN, He R, Duan F, Sheth R, Bathala T, Rao P, Daw DN, Tripathi D, Walker C, Mohammad M, Zhang J, Han G, Chu Y, Wang R, Dang M, Dai E, Peng F, Liu Y, Jadhav A, Lang W, Arrechedera C, Clemente L, Parra PE, Lu H, Haymaker C, Wistuba I, Futreal A, Viale A, Soth M, Jones P, Marszalek J, Heffernan T, Draetta G, Tannir NM, Gao J, Wang L, Genovese G, Msaouel P Myeloid mimicry mediates hyperprogression in patients with renal medullary carcinoma treated with nivolumab plus ipilimumab. Nature Medicine None(None):None. PMID: None.
- Citron F, Perelli L, Ho IL, Chu Y, Balestrieri C, Zhang L, Yen EY, Shah R, Attanasio S, Montanez LC, Srinivasan S, Dyke CA, Chen KC, Jiang S, Pan J, Vanderkruk B, Leung CS, Maitituoheti M, Rai K, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Hoffman BG, Heffernan T, Giuliani V, Wang L, Di Pilato M, Genovese G, Viale A DPY30 regulates immunoediting by suppressing uncoordinated DNA replication in pancreatic cancer. Nature Cancer None(None):None. PMID: None.
Letters to the Editor
- Lucchetti, D, Santini, G, Perelli, L, Ricciardi-Tenore, C, Colella, F, Mores, N, Macis, G, Bush, A, Sgambato, A, Montuschi, P. Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients. The European respiratory journal 58, 2021.
Grant & Contract Support
Title: | Ermenegildo Zegna Founder’s Scholarship |
Funding Source: | Ermenegildo Zegna |
Role: | Key |
Title: | Investigation on the cell of origin and evolutionary trajectories of human Glioblastoma |
Funding Source: | N/A |
Role: | PI |
Title: | Functional and clonal characterization of the paradoxical extinction of KRAS signaling in pancreatic cancer |
Funding Source: | NIH |
Role: | Co-I |
Title: | Investigation of the cell of origin and evolutionary trajectories of human glioblastoma |
Funding Source: | |
Role: | Applicant |