About Luis A Perles
My expertise is in clinical proton therapy dosimetry with emphasis in applying novel film, and scintillator detectors to patient and machine specific quality assurance. I started my career studying the effects of proton Linear Energy Transfer (LET) in film dosimetry and plastic scintillators by correlating Monte Carlo simulations and experimental measurements (see Perles et. al. 2013 and Wang et. al. 2012, both published in Physics in Medicine and Biology). After my postdoctoral fellowship I started working as Junior Medical Physicist at Scripps Proton Therapy Center, San Diego, CA, and subsequently moved to become a proton physicist in Miami Cancer Institute, Miami, FL. In both places I developed methods using film and 2D scintillator dosimetry to assess machine quality assurance. Such task involved developing in-house software to process raw data since many of these systems were not ready to analyze proton pencil beam scanning data. Recently, I have been contributing to the development of 2D and 3D scintillator dosimetry for proton pencil beam scanning.
In summary, from my experience in film and scintillator dosimetry in both research and clinical settings I feel qualified to contribute to the effort to develop a viable solution to the 2D and 3D scintillator dosimetry that can be used in the clinic.
|2006||Universidade de São Paulo, Ribeirao, USA, PHD, Physics Applied in Medicine and Biology|
|2000||Universidade Estadual de Campinas, Campinas, BRA, MSc, Physics|
|1998||Universidade Estadual de Campinas, Campinas, BRA, BS, Physics|
|2019||The American Board of Radiology- Therapeutic Medical Physics|
Institutional Committee Activities
Member, PTCOG Lower GI Subcommittee, 2021 - Present
- Niedzielski JS, Liu Y, Ng SSW, Martin RM, Perles LA, Beddar S, Rebueno N, Koay EJ, Taniguchi C, Holliday EB, Das P, Smith GL, Minsky BD, Ludmir EB, Herman JM, Koong A, Sawakuchi GO. Dosimetric uncertainties resulting from interfractional anatomic variations for patients receiving pancreas stereotactic body radiation therapy and cone-beam CT image guidance. Int J Radiat Oncol Biol Phys 111(5):1298-1309, 2021. e-Pub 2021. PMID: 34400267.
- Perles LA, Mirkovic D, Anand A, Titt U, Mohan R. LET dependence of the response of EBT2 films in proton dosimetry modeled as a bimolecular chemical reaction. Phys Med Biol 58(23):8477-91, 2013. e-Pub 2013. PMID: 24240474.
- Wang LL, Perles LA, Archambault L, Sahoo N, Mirkovic D, Beddar S. Determination of the quenching correction factors for plastic scintillation detectors in therapeutic high-energy proton beams. Phys Med Biol 57(23):7767-81, 2012. e-Pub 2012. PMID: 23128412.
- Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency. Phys Med Biol 55(23):7097-106, 2010. e-Pub 2010. PMID: 21076194.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Med Phys 37(9):4960-70, 2010. PMID: 20964215.
- Perles, L. A., de Almeida, A.. Application of Macro Response Monte Carlo method for electron spectrum simulation. Nucl Instrum Methods Phys Res A 580(1):130-133, 2007.
- Lee WH, Perles LA, Nagem RA, Shrive AK, Hawkins A, Sawyer L, Polikarpov I. Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity. Acta Crystallogr D Biol Crystallogr 58(Pt 5):798-804, 2002. e-Pub 2002. PMID: 11976491.
- Polikarpov I, Golubev AM, Perles LA, Pando SC, Novello JC, Marangoni S. Purification, crystallization and preliminary crystallographic study of a Kunitz-type trypsin inhibitor from Delonix regia seeds. Acta Crystallogr D Biol Crystallogr 55(Pt 9):1611-3, 1999. PMID: 10489463.
- Polikarpov I, Perles LA, de Oliveira RT, Oliva G, Castellano EE, Garratt RC, Craievich A. Set-up and experimental parameters of the protein crystallography beamline at the Brazilian National Synchrotron Laboratory. J Synchrotron Radiat 5(Pt 2):72-6, 1998. PMID: 16687806.