Luis Augusto Perles, PhD, DABR
Department of Radiation Physics, Division of Radiation Oncology
About Luis A Perles
Dr. Perles has an extensive experience in pencil beam scanning (PBS) proton beam therapy and respiratory motion management techniques. His career is defined by a transition from foundational research in Monte Carlo simulations and detector modeling — specifically with GafChromic films — to the clinical implementation of high-precision delivery systems.
Having held physicist roles at the Scripps Proton Therapy Center and Miami Cancer Institute, he has made significant contributions to the optimization PBS and the development of in-house quality assurance software. His recent research focuses on image-guided radiotherapy (IGRT) for complex abdominal sites, including the use of CT-on-Rails and MR-Linac technologies to manage inter and intra- fractional anatomic variations in pancreatic, liver, and renal cancers. Furthermore, his research into the Harrison–Anderson–Mick (HAM) applicator has led to improved understanding of the associated dosimetric uncertainties for intraoperative radiotherapy, directly impacting treatment accuracy for complex surgical cases.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2006 | University of Sao Paulo - USP, Ribeirao Preto, Sao Paulo, BR, Medical Physics, Ph.D. in Physics Applied in Medicine and Biology |
| 2000 | State University of Campinas - UNICAMP, Campinas, Sao Paulo, BR, Physics, M.Sc. in Physics |
| 1998 | State University of Campinas - UNICAMP, Campinas, Sao Paulo, BR, Physics, BS in Physics |
Postgraduate Training
| 2009-2013 | Postdoctoral Fellow, Medical Physics, University of Texas MD Anderson Cancer Center, Houston, Texas |
Licenses & Certifications
| 2020 | Texas Medical Physicists License |
| 2019 | The American Board of Radiology- Therapeutic Medical Physics |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2025
Voluntary Clinical Assistant Professor, Department of Radiation Oncology, University of California San Diego, San Diego, CA, 2015 - 2017
Voluntary Clinical Instructor, Department of Radiation Oncology, University of California San Diego, San Diego, CA, 2014 - 2015
Administrative Appointments/Responsibilities
Leader of IORT program, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Leader of SPECT program, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - 2022
Intramural Institutional Committee Activities
Member, Transition from 2107 to ACB3, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Global Health Initiative - Mozambique outreach, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Rectal brachytherapy, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Commissioning of SFRT, The University of Texas MD Anderson Cancer Center, 2025 - 2025
Leader, Replacement of transfer tubes in IORT, The University of Texas MD Anderson Cancer Center, 2024 - Present
Leader, Use of Dual-Energy CT in GI, The University of Texas MD Anderson Cancer Center, 2024 - Present
Leader, Upgrade of microSelectron HDR unit for IORT, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Quality Assessment and Process Improvement, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, ETHOS working group, The University of Texas MD Anderson Cancer Center, 2024 - Present
Leader, Liver HDR: Transition to GI service, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Implementation of liver SBPT, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Implementation of pancreas SBPT, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, IGRT and motion management, The University of Texas MD Anderson Cancer Center, 2023
Member, VelocityAI upgrade, The University of Texas MD Anderson Cancer Center, 2023 - 2025
Member, IV contrast shortage, The University of Texas MD Anderson Cancer Center, 2022 - 2022
Leader, Compression belt, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Varian RFP Review Committee Meeting, The University of Texas MD Anderson Cancer Center, 2021 - 2021
Member, Siemens CT simulator to replace the AQSim1 Ad Hoc Committee, The University of Texas MD Anderson Cancer Center, 2020 - 2021
Extramural Institutional Committee Activities
Member, Pancreas proton therapy subcommittee, PTCOG, 2021 - 2025
Member, Lower GI proton therapy subcommittee, PTCOG, 2021 - 2024
Guest, Task Group- Report No. 275 - Strategies for Effective Physics Plan and Chart Review in Radiation Therapy, AAPM, American Association of Physicists in Medicine, 2017 - 2017
Editorial Activities
Associate Editor, Journal of Applied Clinical Medical Physics, 2024 - Present
Selected Presentations & Talks
Local Presentations
- 2025. Establishing a universal dosimetric response model for Gafchromic films. Poster. Houston, Texas, US.
- 2025. Intraoperative Radiation Therapy. Invited. Department Seminars. Houston, Texas, US.
National Presentations
- 2023. IORT HDR management and workflow at the UT MD Anderson CC. Invited. AAPM. Houston, TX, US.
- 2022. PTCOG Gastrointestinal Subcommittee Lower GI Tract Malignancies Consensus Statement: Proton Therapy Indications, Treatment Delivery and Case Discussion. Conference. PTCOG. Scottsdale, AZ, US.
- 2019. Isocenter verification (corkscrew effect in IBA gantry). Conference. 8th Annual Proteus IBA User’s Group Meeting. Miami, FL, US.
- 2014. Evaluating the Dose Accuracy of a 2D Ion Chamber Array in High Dose Rate Pencil Beam Scanning Proton Beam. Conference. AAPM, 56th Annual Meeting. Austin, TX, US.
- 2012. Dose Response of EBT2 Film Modeled as a Bimolecular Reaction. Conference. AAPM, 54th Annual Meeting. Charlotte, NC, US.
- 2010. Influence of the material table completeness on the accuracy of MCNPX proton Monte Carlo simulation in lung phantom. Conference. American Nuclear Society. Las Vegas, NV, US.
International Presentations
- 2025. The benefits of Proton Radiotherapy. Invited. Radiotherapy in Focus. Sao Cristovao, BR.
- 2025. The Radiation Planning Assistant. Invited. Radiotherapy in Focus. Sao Cristovao, BR.
- 2025. The Challenges of Research in Medical Physics. Panelist. Radiotherapy in Focus. Sao Cristovao, BR.
- 2025. Landscape of Medical Physics and the Clinical Routine at The UT MD Anderson CC. Invited. Radiotherapy in Focus. Sao Cristovao, BR.
- 2025. Implementation and use of CT on Rails: Challenges and Benefits (Implementação e uso de CT on Rails: Desafios e Benefícios). Invited. 29th Brazilian Congress of Medical Physics. Sao Paulo, BR.
- 2025. The Radiation Planning Assistant in Mozambique. Invited. Maputo, MZ.
- 2021. Proton therapy past, present and future. Invited. XX Semana da Fisica Medica, BR.
- 2021. Developments in proton therapy to treat pediatric patients. Invited. 20th International Union for Pure and Applied Biophysics (IUPAB), 50th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 45th Congress of Brazilian Society of Biophysics (SBBf), 13th Brazilian Society on Nuclear Biosci, BR.
- 2011. 3D proton dose distributions in an anthropomorphic lung phantom, comparing Monte Carlo, film, and TLD measurements. Conference. Joint AAPM / COMP. Vancouver, CA.
- 2006. Simulation of a tandem ionization chamber response using PENELOPE. Conference. 10th International Symposium on Radiation Physics. Coimbra, PT.
- 2006. Simulation of the absorbed energy in thin phantoms irradiated by electrons using the Macro Response Monte Carlo technique. Conference. XI Congresso Brasileiro de Fisica Medica. Ribeirao Preto, BR.
- 2004. A parallel implementation of Geant4 application using OOMPI. Conference. Monte Carlo User Group Meeting (MCNEG). Teddington, GB.
Grant & Contract Support
| Date: | 2025 - 2027 |
| Title: | Varian Alliance Project: MRI & ART |
| Funding Source: | Varian |
| Role: | Co-I |
| Date: | 2024 - Present |
| Title: | Establishing a universal dosimetric model for GafCrhomic films to use in therapeutic and diagnostic dosimetry (Estabelecendo um modelo de dosimetria universal para filmes GafChromicos para uso na dosimetria das radiações em radioterapia e radiologia diagnostica) |
| Funding Source: | CNPq - Brazil |
| Role: | Co-PI |
| Date: | 2024 - 2026 |
| Title: | Early detection of cutaneous melanoma using nanoparticle-assisted near-infrared reflectance imaging |
| Funding Source: | Quantitative Imaging Analysis Core (QIAC) Partnership in Research (QPR) pilot grant, The University of Texas MD Anderson Cancer Center |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Alpha particles combined with ATR inhibition to activate the immune system: mechanisms and pre-clinical translation |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1-R01-CA279119-01 |
Selected Publications
Peer-Reviewed Articles
- Li Y, Martin-Paulpeter RM, Chung CV, Aguilar MA, Matias CA, Delgado A, Nair S, Court LE, Perles LA, Sahoo N, Zhu XR, Poenisch F, Flint DB, Sawakuchi GO, Beddar S, Koay E, Baker JS, Ludmir EB, Niedzielski JS. Novel pencil-beam scanning proton lattice radiation therapy for the treatment of bulky liver cancer: dosimetric comparison with VMAT-lattice radiotherapy. Front. Oncol 15, 2026. e-Pub 2026.
- Khaleghibizaki, M, Sobremonte, A, Perles, LA, Prajapati, S, Subashi, ED, Ding, Y, Brock, K, Barati, R, Koay, EJ, Tang, C, Yang, J. Dosimetric effect of abdominal compression in online adaptive planning for abdominal cancers treated with a 1.5 Tesla magnetic resonance-guided linear accelerator. Physics and Imaging in Radiation Oncology 37, 2026. e-Pub 2026.
- Insley B, Bocian B, Beddar S, Reiazi R, Jensen PJ, Martin-Paulpeter RM, Niedzielski JS, Flint D, Sawakuchi GO, Perles LA. Monte Carlo simulations of geometric deformation of Harrison-Anderson-Mick applicators used in intraoperative radiation therapy. J Appl Clin Med Phys 26(12), 2025. e-Pub 2025. PMID: 41306071.
- Zhao, Y, Cozma, A, Ding, Y, Perles, LA, Reiazi, R, Chen, X, Kang, AM, Prajapati, S, Yu, H, Subashi, ED, Brock, K, Wang, J, Beddar, S, Lee, B, Mohammedsaid, M, Cooper, S, Westley, RL, Tree, A, Mohamad, O, Hassanzadeh, CJ, Mok, H, Choi, S, Tang, C, Yang, J. Upper Urinary Tract Stereotactic Body Radiotherapy Using a 1.5 Tesla Magnetic Resonance Imaging-Guided Linear Accelerator. Cancers 16(23), 2024. e-Pub 2024. PMID: 39682173.
- Ludmir, EB, Sherry, AD, Fellman, B, Liu, S, Bathala, TK, Haymaker, CL, Medina-Rosales, M, Reuben, A, Holliday, EB, Smith, GL, Noticewala, SS, Nicholas, S, Price, TR, Martin, RM, Perles, LA, Lee, SS, Lee, MS, Smaglo, BG, Huey, RW, Willis, JA, Zhao, D, Cohen, L, Taniguchi, C, Koay, EJ, Katz, MH, Wolff, RA, Das, P, Pant, S, Koong, A, Tang, C. Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND). Journal of Clinical Oncology 42(32):3795-3805, 2024. e-Pub 2024. PMID: 39102622.
- Martin, RM, Jensen, PJ, Perles, LA, Sawakuchi, GO, Das, P, Koay, EJ, Koong, A, Ludmir, EB, Niedzielski, JS, Beddar, S. Daily Diagnostic Quality Computed Tomography-on-Rails (CTOR) Image Guidance for Abdominal Stereotactic Body Radiation Therapy (SBRT). Cancers 16(22), 2024. e-Pub 2024. PMID: 39594725.
- Ludmir EB, Sherry AD, Fellman BM, Liu S, Bathala T, Haymaker C, Medina-Rosales MN, Reuben A, Holliday EB, Smith GL, Noticewala SS, Nicholas S, Price TR, Martin-Paulpeter RM, Perles LA, Lee SS, Lee MS, Smaglo BG, Huey RW, Willis J, Zhao D, Cohen L, Taniguchi CM, Koay EJ, Katz MHG, Wolff RA, Das P, Pant S, Koong AC, Tang C. Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): a Multicenter, Randomized Phase II Trial. Journal of Clinical Oncology 42(32):3795-3805, 2024. e-Pub 2024.
- Chang E, Wong FCL, Chasen BA, Erwin WD, Das P, Holliday EB, Koong AC, Ludmir EB, Minsky BD, Noticewala SS, Smith GL, Taniguchi CM, Rodriguez MJ, Beddar S, Martin-Paulpeter RM, Niedzielski JS, Sawakuchi GO, Schueler E, Perles LA, Xiao L, Szklaruk J, Park PC, Dasari AN, Kaseb AO, Kee BK, Lee SS, Overman MJ, Willis JA, Wolff RA, Tzeng CD, Vauthey JN, Koay EJ. Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume. JNCI Cancer Spectr 8(3), 2024. e-Pub 2024. PMID: 38730548.
- Choi JI, Wojcieszynski A, Amos RA, Giap H, Apisarnthanarax S, Ashman JB, Anand A, Perles LA, Williamson T, Ramkumar S, Molitoris J, Simone CB, Chuong MD. PTCOG Gastrointestinal Subcommittee Lower Gastrointestinal Tract Malignancies Consensus Statement. Int J Part Ther 11:100019, 2024. e-Pub 2024. PMID: 38757077.
- Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT-XD film to therapeutic protons. Precis Radiat Oncol 7(1):15-26, 2023. e-Pub 2023. PMID: 37868341.
- Rhee DJ, Beddar S, Jaoude JA, Sawakuchi G, Martin R, Perles L, Yu C, He Y, Court LE, Ludmir EB, Koong AC, Das P, Koay EJ, Taniguichi C, Niedzielski JS. Dose Escalation for Pancreas SBRT: Potential and Limitations of using Daily Online Adaptive Radiation Therapy and an Iterative Isotoxicity Automated Planning Approach. Advances in Radiation Oncology 8(4), 2023. e-Pub 2023.
- Niedzielski JS, Liu Y, Ng SSW, Martin RM, Perles LA, Beddar S, Rebueno N, Koay EJ, Taniguchi C, Holliday EB, Das P, Smith GL, Minsky BD, Ludmir EB, Herman JM, Koong A, Sawakuchi GO. Dosimetric uncertainties resulting from interfractional anatomic variations for patients receiving pancreas stereotactic body radiation therapy and cone-beam CT image guidance. Int J Radiat Oncol Biol Phys 111(5):1298-1309, 2021. e-Pub 2021. PMID: 34400267.
- Perles LA, Mirkovic D, Anand A, Titt U, Mohan R. LET dependence of the response of EBT2 films in proton dosimetry modeled as a bimolecular chemical reaction. Phys Med Biol 58(23):8477-91, 2013. e-Pub 2013. PMID: 24240474.
- Wang LL, Perles LA, Archambault L, Sahoo N, Mirkovic D, Beddar S. Determination of the quenching correction factors for plastic scintillation detectors in therapeutic high-energy proton beams. Phys Med Biol 57(23):7767-81, 2012. e-Pub 2012. PMID: 23128412.
- Titt U, Mirkovic D, Sawakuchi GO, Perles LA, Newhauser WD, Taddei PJ, Mohan R. Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency. Phys Med Biol 55(23):7097-106, 2010. e-Pub 2010. PMID: 21076194.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Med Phys 37(9):4960-70, 2010. e-Pub 2010. PMID: 20964215.
- Perles LA, de Almeida A. Application of Macro Response Monte Carlo method for electron spectrum simulation. Nucl Instrum Methods Phys Res A 580(1):130-133, 2007. e-Pub 2007.
- Lee WH, Perles LA, Nagem RA, Shrive AK, Hawkins A, Sawyer L, Polikarpov I. Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity. Acta Crystallogr D Biol Crystallogr 58(Pt 5):798-804, 2002. e-Pub 2002. PMID: 11976491.
- Polikarpov I, Golubev AM, Perles LA, Pando SC, Novello JC, Marangoni S. Purification, crystallization and preliminary crystallographic study of a Kunitz-type trypsin inhibitor from Delonix regia seeds. Acta Crystallogr D Biol Crystallogr 55(Pt 9):1611-3, 1999. e-Pub 1999. PMID: 10489463.
- Polikarpov I, Perles LA, de Oliveira RT, Oliva G, Castellano EE, Garratt RC, Craievich A. Set-up and experimental parameters of the protein crystallography beamline at the Brazilian National Synchrotron Laboratory. J Synchrotron Radiat 5(Pt 2):72-6, 1998. e-Pub 1998. PMID: 16687806.
Review Articles
- Chhabra, A, Amos, R, Simone, C, Kaiser, A, Perles, LA, Giap, H, Hallemeier, C, Johnson, JE, Lin, H, Wroe, AJ, Diffenderfer, ES, Wolfgang, JA, Sakurai, H, Lu, HM, Hong, TS, Koay, EJ, Terashima, K, Vitek, P, Rule, WG, Apisarnthanarax, SJ, Badiyan, S, Molitoris, JK, Chuong, MD, Nichols, RC. Proton Beam Therapy for Pancreatic Tumors. International Journal of Radiation Oncology Biology Physics 122(1):19-30, 2025. e-Pub 2025. PMID: 39761799.
Other Articles
- Chang E, Holliday EB, Szklaruk J, Erwin WD, Ludmir EB, Noticewala SS, Das P, Koong AC, Minsky BD, Smith GL, Sawakuchi GO, Martin-Paulpeter RM, Niedzielski JS, Perles LA, Beddar S, Valino VS, Nguyen JL, Raghav KP, Javle M, Kaseb AO, Dasari AN, Overman MJ, Parseghian CM, Odisio BC, Mahvash A, Kuban JD, Shen S, Wang XS, Gupta AC, Al Taie MM, Brock KK, Tzeng CD, Vauthey J, Wong FC, Koay EJ Single Photon Emission Computed Tomography Functional Liver Imaging to Facilitate Reirradiation for Liver Malignancies: A Phase I Trial. JHEP Reports, 2026.
Abstracts
- Khaleghibizaki M, Sobremonte A, Perles LA, Prajapati S, Subashi ED, Ding Y, Brock KK, Koay EJ, Tang C, Yang J. Impact of Abdominal Compression in MR-Guided Online Adaptive Planning for Abdominal Cancers Treated with a 1.5 Tesla MR-Linac. ASTRO 2025 Annual Meeting, 2025. e-Pub 2025.
- Bocian B, Perles LA, Tien CJ, Jensen PJ. Computational Prototype Single-Channel Vaginal Cylinder with Integrated Filter to Address Dose Uniformity in High-Dose-Rate Brachytherapy for Endometrial Cancer. AAPM 2025 Annual Meeting, 2025. e-Pub 2025.
- Ruzek JS, Hoang AM, Dehghanpour M, Baker J, Martin Paulpeter RM, Niedzielski JS, Beddar S, Sawakuchi GO, Holliday EB, Perles LA. A comparison of the impact to mean doses to organs at risk of small versus large spot sizes in pelvic proton therapy. AAPM 2025 Annual Meeting, 2025. e-Pub 2025.
- Chung CV, Nair SS, Khan M, Nguyen C, Perles LA, Ludmir EB, Martin Paulpeter, Court LE, Niedzielski JS. Feasibility of Rapidarc Dynamic for Lattice Radiation Therapy of Bulky Liver Tumors. AAPM 2025 Annual Meeting, 2025. e-Pub 2025.
- Insley BA, Bocian B, Reiazi R, Jensen PJ, Martin Paulpeter RM, Niedzielski JS, Beddar S, Flint D, Sawakuchi GO, Perles LA. Monte Carlo Simulation of Dose Perturbations in HAM Applicator HDR Brachytherapy Treatments. AAPM 2025 Annual Meeting, 2025. e-Pub 2025.
- Hoang A, Ruzek J, Dehghanpour M, Baker J, Paulpeter RM, Niedzielski J, Beddar S, Sawakuchi G, Holliday EB, Perles LA. Evaluation of Beam Arrangements for Anal Canal Treatment Using Proton Pencil Beam Scanning. AAMD 2025 Annual Meeting, 2025. e-Pub 2025.
- Zhao Y, Yang J, Perles L, Reiazi R, Chen X, Prajapati S, Subashi E, Yu H, Brock K, Wang J, Mohamad O, Hassanzadeh C, Choi S, Tang C, Ding Y. Respiratory Motion Management using Compression Belt for MR-guided Stereotactic Body Radiotherapy of Kidney Cancer. AAPM, 66th Annual Meeting, 2024. e-Pub 2024.
- Chang E, Wong FCL, Erwin WD, Das P, Holliday E, Koong AC, Ludmir EB, Smith GL, Taniguchi CM, Beddar S, Martin R, Niedzielski J, Perles LA, Park PC, Kaseb A, Lee S, Tzeng CW, Vauthey JN, Koay EJ. Phase 1 Trial of SPECT-Guided Liver-Directed Ablative Radiotherapy for Patients with Low Functional Liver Volume. ASTRO, Annual meeting 2023 117(2):S106, 2023. e-Pub 2023.
- Perles LA, Niedzielski J, Sawakuchi G, Martin R, Schueler E, Taniguchi CM, Ludmir EB, Vivar OI, Das P, Koong AC, Farber LA, Koay EJ, Beddar S. Assessment of the Spatial Bio-distribution of NBTXR3 for Locally Advanced or Borderline-Resectable Pancreatic Ductal Adenocarcinoma (LAPC or BRPC) Patients Undergoing Radiation Therapy. ASTRO, Annual meeting 2023 117(2), 2023. e-Pub 2023.
- Amos R, Diffenderfer E, Johnson J, Lin H, Perles L, Wolfgang J, Simone C, Chuong M, Giap H, Nichols R. Technical considerations for the planning and delivery of proton beam therapy for pancreas cancer: Consensus of the PTCOG Gastrointestinal Subcommittee, 2023. e-Pub 2023.
- Amos RA, Diffenderfer ES, Johnson JEJ, Lin H, Perles LA, Wolfgang JA, Simone II CB, Chuong MD, Giap HB, Apisarnthanarax S, Molitoris JK, Chhabra AM, Hallemeier CL, Koay EJ, Badiyan SN, Vitek P, Nichols RC. Proton Beam Therapy for Pancreas Cancer: PTCOG Consensus Recommendations for Simulation, Treatment Planning and Treatment Delivery 114(3):E188-9, 2022. e-Pub 2022.
- Alsanea F, Williamson T, Poenisch F, Martin R, Beddar S, Sawakuchi G, Perles L, Ludmir E, Koong A, Das P, Taniguchi C, Koay E, Niedzielski J. Feasibility of Intensity Modulated Proton Therapy for Treating Pancreatic Cancer Using a Hypofractionated Approach. PTCOG, 2022. e-Pub 2022.
- Choi JI, Wojcieszynski A, Amos R, Giap H, Apisarnthanarax A, Ashman J, Anand A, Perles LA, Williamson T, Shanmugasundaram R, Molitoris J, Simone C, Chuong M. PTCOG Gastrointestinal Subcommittee Lower GI Tract Malignancies Consensus Statement: Proton Therapy Indications, Treatment Delivery and Case Discussion. ARS, American Radium Society 104th Annual Meeting, 2022. e-Pub 2022.
- Niedzielski J, Beddar S, Martin R, Perles L, Rebueno N, Holliday E, Smith G, Minsky B, Ludmir E, Das P, Koay E, Taniguchi C, Koong A, Sawakuchi G. Towards Daily Online Adaptive SBRT for Pancreatic Cancer: Dosimetric Analysis of Daily Adaptive Re-Planning Using Re-Optimization and Dose Escalation Techniques. AAPM, 63rd Annual Meeting, 2021. e-Pub 2021.
- Darne C, Robertson D, Alsanea F, Tendler I, Perles L, Collins-Fekete C, Beddar S. A Novel Integrating Proton Radiography System with a Monolithic Scintillator Detector, 2021. e-Pub 2021.
- George J, Bennouna J, Rana S, Yu J, Coutinho L, Hobson M, Perles L, George S, Gutierrez A. Long Term Stability of KV Cone Beam CT (CBCT) Image Quality Assurance for IBA Proteus PLUS Proton Therapy System, 2020. e-Pub 2020.
- Perles L, Hobson M, Gutierrez A. Evaluation and Commissioning of the SDX Spirometer Based System for Use in Proton Pencil Beam Scanning Treatment Under Deep Inspiration Breath-Hold, 2020. e-Pub 2020.
- Hobson MA, Perles L. Optimal Electrometer Selection for PBS Dosimetry, 2020. e-Pub 2020.
- Perles L. Multi-Energy Isocenter Analysis in Proton Pencil Beam Scanning System, 2020. e-Pub 2020.
- Perles L, Coutinho L, Rana S, Gutierrez A. Spot Size and Position Analysis of a Pencil Beam Scanning System, 2019. e-Pub 2019.
- Zhang Y, Giebeler A, Mascia A, Piskulich F, Perles L, Lepage R, Dong L. Dosimetric Impact of In‐Air Spot Size Variations for Commissioning a Room‐Matched Beam Model for Pencil Beam Scanning Proton Therapy, 2014. e-Pub 2014.
- Titt U, Mirkovic D, Liu A, Anand A, Perles L, Ciangaru G, Mohan R. Commissioning of the MC2 Monte Carlo Dose Computation Engine, 2014. e-Pub 2014.
- Piskulich F, Zhang Y, Perles L, Mascia A, Lepage R, Giebeler A, Dong L. Initial Experience of Patient‐Specific QA Using a Pencil Beam Scanning Proton Therapy System, 2014. e-Pub 2014.
- Perles L, Mascia A, Piskulich F, Lepage R, Zhang Y, Giebeler A, Dong L. Evaluating the Dose Accuracy of a 2D Ion Chamber Array in High Dose Rate Pencil Beam Scanning Proton Beam, 2014. e-Pub 2014.
- Perles LA, Titt U, Mirkovic D, Mohan R. Modeling the Cell Inactivation Process for High LET Particles by Using the Law of Mass Action, 2013. e-Pub 2013.
- Peeler C, Mirkovic D, Perles L, Titt U, Grosshans D, Mohan R. Comparison of Results for RBE‐Weighted Dose From Two RBE Models for Proton Therapy Treatment Plans, 2013. e-Pub 2013.
- Mirkovic D, Titt U, Peeler C, Perles L, Liao Z, Mohan R. Variable RBE and Incidence of Radiation Pneumonitis in Lung Patients Treated with Proton Therapy, 2013. e-Pub 2013.
- Guan F, Mohan R, Dinh J, Kerr M, Perles L, Mirkovic D, Titt U, Zhu X, Gillin M, Meyn R, Lin S, Grosshans D. Experimental Design and Preliminary Results for High‐Resolution and High‐Throughput In‐Vitro Measurements of Proton RBE, 2013. e-Pub 2013.
- Sell M, Titt U, Perles L, Mirkovic D, Mohan R, Bangert M, Oelfke U. Evaluation of Analytical Proton Dose Predictions with a Lung-Like Plastic Phantom, 2012. e-Pub 2012.
- Titt U, Mirkovic D, Perles L, Sell M, Peeler C, Liu A, Mohan R. Monte Carlo Phase Space Production to Model Magnetically Scanned Proton Beams for IMPT, 2012. e-Pub 2012.
- Perles L, Mirkovic D, Anand A, Titt U, Mohan R. Dose Response of EBT2 Film Modeled as a Bimolecular Reaction, 2012. e-Pub 2012.
- Perles LA, Blatnica AP, Mirkovic D, Titt U, Gillin MT, Ibbot GS, Mohan R. Experimental Verification Of Proton Dose Delivered To The Target In An Anthropomorphic Lung Phantom. International Journal of Radiation Oncology Biology Physics 81(2):S877, 2011. e-Pub 2011.
- Perles LA, Mirkovic D, Sawakuchi GO, Titt U. Monte Carlo investigation of rebinning material density distributions of lung parenchyma phantoms in proton therapy. Nuclear Technology 175(1):22-26, 2011. e-Pub 2011.
- Wang L, Perles L, Archambault L, Sahoo N, Beddar S, Mirkovic D. Application of a Plastic Scintillation Detector in Measuring Depth‐Dose Curves for Passive‐Scattering Proton Beams, 2011. e-Pub 2011.
- Titt U, Mirkovic D, Anand A, Perles L, Sawakuchi G, Mohan R. On the Dependence of Scanned Proton Beam Dose Output Factors on the Field Size and the Accuracy of the Lateral Dose Profiles, 2011. e-Pub 2011.
- Perles LA, Ibbott GS, Blatnica A, Mirkovic D, Titt U, Gillin M, Mohan R. 3D Proton Dose Distributions in an Anthropomorphic Lung Phantom, Comparing Monte Carlo, Film, and TLD Measurements, 2011. e-Pub 2011.
- Perles L, Sawakuchi G, Mirkovic D, Mohan R, Titt U. Monte Carlo Investigation and Measurements of Distal Edge Degradation in Lung Phantoms with Therapeutic Proton Beams, 2010. e-Pub 2010.
- Perles LA, de Almeida A. Application of Macro Response Monte Carlo method for electron spectrum simulation, 2006. e-Pub 2006.
- Pianoschi TA, Perles LA, Costa AM, Pela C. Simulation of a tandem ionization chamber response using PENELOPE, 2006. e-Pub 2006.
- Moreira M V, Almeida A, Costa R T, and Perles L A. FXG mass attenuation coefficient evaluation for radiotherapy routine. Journal of Physics: Conference Series(3):146-149, 2004. e-Pub 2004.
Patient Reviews
CV information above last modified March 11, 2026