Madeleine Duvic, M.D.
Department of Dermatology, Division of Internal Medicine
About Dr. Duvic
Madeleine Duvic, M.D., I went to Duke to become a clinician scientist interested in T-cell immunology and in translational research. My goal is to understand the pathogenesis of T-cell mediated skin diseases in order to develop novel targeted therapy. I have collaborated with pharmacology to develop protocols and then conduct clinical trials that lead to the registration of new FDA approved agents for cutaneous T-cell lymphoma that include bexarotene (first rexinoid), denileukin diftitox (first targeted fusion toxin), and vorinostat (first histone deacetylase inhibitor). In addition to directing an NIH funded molecular biology lab and a clinical trials research team, I personally have cared for over 2,000 MD Anderson cutaneous T-cell lymphoma patients. I belong to the UT graduate school immunology program. As a past recipient of a K24 award in cutaneous oncology, I continue to actively mentor research fellows, residents, PhDs, and medical students.
Present Title & Affiliation
Primary Appointment
Blanche Bender Professorship in Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Department Chair, Department of Dermatology, Division of Internal Medicine, UTMDACC, Houston, TX
Director of the Research Fellowship Program, Department of Dermatology, Division of Internal Medicine, UTMDACC, Houston, TX
Professor of Medicine and Dermatology (with tenure), Division of Internal Medicine, UTMDACC, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Division of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas School of Public Health, Houston, TX
Professor of Medicine and Dermatology, The University of Texas Medical School at Houston (UTMSH), Houston, TX
Clinical Interests
- Cutaneous lymphomas and Sezary syndrome
- Skin cancer and melanoma
Education & Training
Degree-Granting Education
| 1977 | Duke University Medical School, Durham, NC, USA, MD, Medicine |
| 1973 | Rice University, Houston, TX, USA, BA, Biology |
Postgraduate Training
| 1984-1985 | Research Visiting Fellow, Molecular Genetics, Baylor College of Medicine, Houston, TX |
| 1982-1984 | Postdoctoral Fellowship, Molecular Genetics & Geriatrics, Duke University, Durham, NC |
| 1981-1982 | Residency in Internal Medicine, Duke University, Durham, NC |
| 1979-1979 | Chief Resident, Dermatology, Duke University, Durham, NC |
| 1978-1980 | Residency in Dermatology, Duke University, Durham, NC |
| 1977-1978 | Internship in Internal Medicine, Duke University, Durham, NC |
Board Certifications
| 1982 | American Board of Internal Medicine |
| 1981 | American Board of Dermatology |
Honors & Awards
| 2001 | America's Top Doctors, Castle Connolly Medical Ltd |
| 1994 | Best Doctors in America |
Selected Publications
Peer-Reviewed Articles
- Quaglino P, Maule M, Prince HM, Porcu P, Horwitz S, Duvic M, Talpur R, Vermeer M, Bagot M, Guitart J, Papadavid E, Sanches JA, Hodak E, Sugaya M, Berti E, Ortiz-Romero P, Pimpinelli N, Servitje O, Pileri A, Zinzani PL, Estrach T, Knobler R, Stadler R, Fierro MT, Alberti Violetti S, Amitay-Laish I, Antoniou C, Astrua C, Chaganti S, Child F, Combalia A, Fabbro S, Fava P, Grandi V, Jonak C, Martinez-Escala E, Kheterpal M, Kim EJ, McCormack C, Miyagaki T, Miyashiro D, Morris S, Muniesa C, Nikolaou V, Ognibene G, Onida F, Osella-Abate S, Porkert S, Postigo-Llorente C, Ram-Wolff C, Ribero S, Rogers K, Sanlorenzo M, Stranzenbach R, Spaccarelli N, Stevens A, Zugna D, Rook AH, Geskin LJ, Willemze R, Whittaker S, Hoppe R, Scarisbrick J, Kim Y. Global patterns of care in advanced stage mycosis fungoides/Sezary Syndrome a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium. Ann Oncol 28(10):2517-2525, 2017. PMID: 28961843.
- Lewis DJ, Kim EJ, Duvic M. Recent advances in systemic targeted therapy for cutaneous T-cell lymphoma. Expert Opin Pharmacother 18(14):1-2, 2017. e-Pub 2017. PMID: 28803489.
- Lewis DJ, Byekova YA, Emge DA, Duvic M. Complete resolution of mycosis fungoides tumors with imiquimod 5% cream: a case series. J Dermatolog Treat 28(6):1-3, 2017. e-Pub 2017. PMID: 28635518.
- Lewis DJ, Huang S, Duvic M. Oral bexarotene for post-transplant cutaneous T-cell lymphoma. Dermatol Ther 30(5), 2017. e-Pub 2017. PMID: 28748653.
- Winsett FT, Lewis DJ, Duvic M. Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma. Expert Rev Hematol 10(9):757-760, 2017. e-Pub 2017. PMID: 28756726.
- Kim EJ, Lewis DJ, Duvic M. Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome. J Invest Dermatol 137(9):1831-1833, 2017. PMID: 28843295.
- Li JY, Lewis DJ, Duvic M. Generalised Eruptive Keratoacanthomas of Grzybowski. J Cutan Med Surg 21(5):439, 2017. PMID: 28920475.
- Ni X, Zhang X, Hu CH, Langridge T, Tarapore RS, Allen JE, Oster W, Duvic M. ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways. Oncotarget 8(37):61761-61776, 2017. e-Pub 2017. PMID: 28977902.
- Wieser I, Wang C, Alberti-Violetti S, Lyons G, Tran C, Talpur R, Duvic M. Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides. Arch Dermatol Res 309(6):453-459, 2017. e-Pub 2017. PMID: 28516243.
- Wieser I, Huean A, Bush AE, Dabaja BS, Duvic M. Periorbital involvement in early stage mycosis fungoides. Acta Derm Venereol 97(8):976-978, 2017. e-Pub 2017. PMID: 28421231.
- Prince HM, Kim YH, Horwitz SM, Dummer R, Scarisbrick J, Quaglino P, Zinzani PL, Wolter P, Sanches JA, Ortiz-Romero PL, Akilov OE, Geskin L, Trotman J, Taylor K, Dalle S, Weichenthal M, Walewski J, Fisher D, Dréno B, Stadler R, Feldman T, Kuzel TM, Wang Y, Palanca-Wessels MC, Zagadailov E, Trepicchio WL, Zhang W, Lin HM, Liu Y, Huebner D, Little M, Whittaker S, Duvic M, ALCANZA study group. Brentuximab vedotin or physician's choice in CD30 expressing cutaneous T cell lymphoma. Lancet 50140-6736(17):31266-7, 2017. e-Pub 2017. PMID: 28600132.
- Duvic M, Kim YH, Zinzani PL, Horwitz SM. Results from a Phase I/II open-label, dose-finding study of Pralatrexate and oral Bexarotene in patients with relapsed/refractory cutaneous T-cell lymphoma. Clin Cancer Res 23(14):3552-3556, 2017. e-Pub 2017. PMID: 28167509.
- Lewis DJ, Duvic M. A possible association between mycosis fungoides and Muir-Torre syndrome: two disorders with microsatellite instability. JAAD Case Rep 3(4):358-361, 2017. e-Pub 2017. PMID: 28761921.
- Kim EJ, Lewis DJ, Dabaja BS, Duvic M. Curcumin for the treatment of tumor-stage mycosis fungoides. Dermatol Ther 30(4), 2017. e-Pub 2017. PMID: 28585397.
- Lewis DJ, Turkeltaub AE, Dai J, Nagarajan P, Rieger KE, Nunez CA, Kim YH, Duvic M. An adolescent with granulomatous mycosis fungoides infiltrating skeletal muscle successfully treated with oral prednisone. JAAD Case Rep 3(4):276-279, 2017. e-Pub 2017. PMID: 28653029.
- Lewis DJ, Duvic M. Forodesine in the treatment of cutaneous T-cell lymphoma. Expert Opin Investig Drugs 26(6):771-5, 2017. e-Pub 2017. PMID: 28447489.
- Litvinov IV, Tetzlaff MT, Thibault P, Gangar P, Moreau L, Watters AK, Netchiporouk E, Pehr K, Prieto VG, Rahme E, Provost N, Gilbert M, Sasseville D, Duvic M. Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators. Oncoimmunology 6(5):e1306618, 2017. e-Pub 2017. PMID: 28638728.
- Guitart J, Martinez-Escala ME, Subtil A, Duvic M, Pulitzer MP, Olsen EA, Kim E, Rook AH, Samimi SS, Wood GS, Girardi M, Junkins-Hopkins J, Ivan DS, Selim MA, Sable KA, Virmani P, Pincus LB, Tetzlaff MT, Kim J, Kim YH. Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. Mod Pathol 30(5):761-772, 2017. e-Pub 2017. PMID: 28128277.
- Lewis DJ, Duvic M. Extracorporeal photopheresis for the treatment of early-stage mycosis fungoides. Dermatol Ther 30(3), 2017. e-Pub 2017. PMID: 28338261.
- Agbay RL, Torres-Cabala CA, Patel KP, Merril ED, Duvic M, Quesada A, Prieto VG, Aung PP, Loghavi S, Young KH, Hu S, Ferrufino-Schmidt MC, Tetzlaff M, Li S, Medeiros LJ, Miranda RN. Immunophenotypic Shifts in Primary Cutaneous γδ T-Cell Lymphoma Suggest Antigenic Modulation: A Study of Sequential Biopsy Specimens. Am J Surg Pathol 41(4):431-445, 2017. e-Pub 2017. PMID: 28248813.
- Min HY, Lee SC, Woo JK, Jung HJ, Park KH, Jeong HM, Hyun SY, Cho J, Lee W, Park JE, Kwon SJ, Lee HJ, Ni X, Shin YK, Johnson FM, Duvic M, Lee HY. Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors. Clin Cancer Res 23(5):1299-1311, 2017. e-Pub 2016. PMID: 27582487.
- Curry JL, Tetzlaff MT, Nagarajan P, Drucker C, Diab A, Hymes SR, Duvic M, Hwu WJ, Wargo JA, Torres-Cabala CA, Rapini RP, Prieto VG. Diverse types of dermatologic toxicities from immune checkpoint blockade therapy. J Cutan Pathol 44(2):158-176, 2017. e-Pub 2016. PMID: 27859479.
- Merrill ED, Agbay R, Miranda RN, Aung PP, Tetzlaff MT, Young KH, Curry JL, Nagarajan P, Ivan D, Prieto VG, Medeiros LJ, Duvic M, Torres-Cabala CA. Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (γδ) Phenotype and Predominantly Epidermotropic Pattern are Clinicopathologically Distinct From Classic Primary Cutaneous γδ T-Cell Lymphomas. Am J Surg Pathol 41(2):204-215, 2017. e-Pub 2016. PMID: 27879514.
- Lefrançois P, Tetzlaff MT, Moreau L, Watters AK, Netchiporouk E, Provost N, Gilbert M, Ni X, Sasseville D, Duvic M, Litvinov IV. TruSeq-Based Gene Expression Analysis of Formalin-Fixed Paraffin-Embedded (FFPE) Cutaneous T-Cell Lymphoma Samples: Subgroup Analysis Results and Elucidation of Biases from FFPE Sample Processing on the TruSeq Platform. Front Med (Lausanne) 4:153, 2017. e-Pub 2017. PMID: 29018799.
- Duvic M, Evans M, Wang C. Mogamulizumab for the treatment of cutaneous T-cell lymphoma: recent advances and clinical potential. Ther Adv Hematol 7(3):171-4, 2016. e-Pub 2016. PMID: 27247757.
- Duvic M, Bates SE, Piekarz R, Eisch R, Kim YH, Lerner A, Robak T, Samtsov A, Becker JC, McCulloch W, Waksman J, Whittaker S. Responses to Romidepsin in patients with cutaneous T-cell lymphoma and prior treatment with systemic chemotherapy. Leuk Lymphoma:1-8. e-Pub 2017. PMID: 28853310.
- Lewis DJ, Talpur R, Huen AO, Tetzlaff MT, Duvic M. Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results. JAMA Dermatol. e-Pub 2017. PMID: 28980004.
- Lewis DJ, Kim YH, Duvic M. Alternate dosing regimens of brentuximab vedotin for CD30+ cutaneous T-cell lymphoma. Br J Dermatol. e-Pub 2017. PMID: 28889405.
- Lewis DJ, Vin H, Hinojosa T, Tetzlaff MT, Dabaja BS, Duvic M. Primary Cutaneous Peripheral T-Cell Lymphoma in a Sporotrichoid Pattern: A Case Report. J Cutan Med Surg:1203475417721425. e-Pub 2017. PMID: 28712310.
Abstracts
- Jiang W, Abou Yehia Z, Dabaja B, Duvic M, Milgrom SA, Pinnix CC, Oki Y, D'Souza N, Smith GL. #42 CD4:CD8 Ratio in Mycosis Fungoides: Prognostic and Predictive Value of Circulating T Lymphocyte Subsets for Outcomes After Total Skin Electron Beam Radiation. Int J Radiat Oncol Biol Phys-58th Annual meeting of American Soc of Rad Onc Boston MA Sept 24-28, 2016 96(2S):S20, 2016. PMID: 27675777.
- Smith GL, Duvic M, Yehia ZA, Allen PK, Garg N, Suki T, Milgrom SA, Pinnix CC, Oki Y, Dabaja B. #85 Effectiveness of Very Low- and Low-Dose Radiation for Primary Cutaneous Anaplastic Large Cell Lymphoma. Int J Radiat Oncol Biol Phys-58th Annual meeting of American Soc of Rad Onc Boston MA Sept 24-28, 2016 96(2S):S38-S39, 2016. PMID: 27675916.
Book Chapters
- Pozadzides J, Duvic M, Pro B. Chapter 9: T-cell lymphomas. In: The MD Anderson Manual of Medical Oncology, 3rd Ed. 3rd. McGraw-Hill, 2014.
- Duvic M. Cutaneous T-cell lymphomas: Mycosis fungoides and Sezary syndrome. In: Lymphoma: Diagnosis and Treatment. Springer: New York, 287-329, 2013.
Books (edited and written)
- Vahquist A, Duvic M. Retinoids and Carotenoids in Dermatology. Ed(s) Taylor & Frances. Taylor & Frances, 2007.
- Werth VP, Duvic M. Dermatologic Clinics on Medical Dermatology. WB Saunders, Inc, 2001.