Madeleine Duvic, M.D.
Department of Dermatology, Division of Internal Medicine
About Dr. Duvic
Madeleine Duvic, M.D., I went to Duke to become a clinician scientist interested in T-cell immunology and in translational research. My goal is to understand the pathogenesis of T-cell mediated skin diseases in order to develop novel targeted therapy. I have collaborated with pharmacology to develop protocols and then conduct clinical trials that lead to the registration of new FDA approved agents for cutaneous T-cell lymphoma that include bexarotene (first rexinoid), denileukin diftitox (first targeted fusion toxin), and vorinostat (first histone deacetylase inhibitor). In addition to directing an NIH funded molecular biology lab and a clinical trials research team, I personally have cared for over 2,000 MD Anderson cutaneous T-cell lymphoma patients. I belong to the UT graduate school immunology program. As a past recipient of a K24 award in cutaneous oncology, I continue to actively mentor research fellows, residents, PhDs, and medical students.
Present Title & Affiliation
Primary Appointment
Deputy Department Chair, Department of Dermatology, Division of Internal Medicine, UTMDACC, Houston, TX
Professor of Medicine and Dermatology (with tenure), Division of Internal Medicine, UTMDACC, Houston, TX
Blanche Bender Professorship in Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Division of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas School of Public Health, Houston, TX
Professor of Medicine and Dermatology, Department of Dermatology, The University of Texas Medical School at Houston (UTMSH), Houston, TX
Clinical Interests
- Cutaneous lymphomas and Sezary syndrome
- Skin cancer and melanoma
Education & Training
Degree-Granting Education
| 1977 | Duke University Medical School, Durham, NC, USA, MD, Medicine |
| 1973 | Rice University, Houston, TX, USA, BA, Biology |
Postgraduate Training
| 1984-1985 | Research Visiting Fellow, Molecular Genetics, Baylor College of Medicine, Houston, TX |
| 1982-1984 | Postdoctoral Fellowship, Molecular Genetics & Geriatrics, Duke University, Durham, NC |
| 1981-1982 | Residency in Internal Medicine, Duke University, Durham, NC |
| 1979-1979 | Chief Resident, Dermatology, Duke University, Durham, NC |
| 1978-1980 | Residency in Dermatology, Duke University, Durham, NC |
| 1977-1978 | Internship in Internal Medicine, Duke University, Durham, NC |
Board Certifications
| 1982 | American Board of Internal Medicine |
| 1981 | American Board of Dermatology |
Honors & Awards
| 2018 | Gagel Career Achievement Award, UT MD Anderson Cancer Center |
| 2001 | America's Top Doctors, Castle Connolly Medical Ltd |
| 1994 | Best Doctors in America |
Selected Publications
Peer-Reviewed Articles
- Fountain E, Mistry H, Jain P, Duvic M, Fowler N. Response to Pembrolizumab and Lenalidomide in advanced refractory mycosis fungoides. Leuk Lymphoma 60(4):1-4, 2019. e-Pub 2018. PMID: 30301395.
- Méhul B, Ménigot C, Fogel P, Seraidaris A, Genette A, Pascual T, Duvic M, Voegel JJ. Proteomic analysis of stratum corneum in Cutaneous T-Cell Lymphomas and psoriasis. Exp Dermatol 28(3):317-321, 2019. e-Pub 2019. PMID: 30637808.
- An Y, Jiang W, Andraos TY, Reddy JP, Yehia ZA, Lloyd S, Duvic M, D'Souza NM, Milgrom SA, Pinnix CC, Oki Y, Smith GL, Wilson LD, Dabaja BS. Multi-institutional investigation: circulating CD4:CD8 ratio is a prognosticator of response to total skin electron beam radiation in mycosis fungoides. Radiother Oncol 131:88-92, 2019. e-Pub 2018. PMID: 30773193.
- Welborn M, Duvic M. Antibody-based therapies for cutaneous T-cell lymphoma. Am J Clin Dermatol 20(1):115-122, 2019. e-Pub 2018. PMID: 30430444.
- Kim EJ, Aria AB, Wilmas K, Lewis DJ, Torres-Cabala CA, Nunez C, Dabaja BS, Duvic M. Primary cutaneous CD4+ small- to medium-sized pleomorphic T-cell lymphoproliferative disorder in a pediatric patient successfully treated with low-dose radiation. Pediatr Dermatol 36(1):e23-e26, 2019. e-Pub 2018. PMID: 30548331.
- Lefrançois P, Xie P, Wang L, Tetzlaff MT, Moreau L, Watters AK, Netchiporouk E, Provost N, Gilbert M, Ni X, Sasseville D, Wheeler DA, Duvic M, Litvinov IV. Gene expression profiling and immune cell-type deconvolution highlight robust disease progression and survival markers in multiple cohorts of CTCL patients. Oncoimmunology 7(8):e1467856, 2018. e-Pub 2018. PMID: 30221071.
- Seto AG, Beatty X, Lynch JM, Hermreck M, Tetzlaff M, Duvic M, Jackson AL. Cobomarsen, an oligonucleotide inhibitor of miR-155, coordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol 183(3):428-444, 2018. e-Pub 2018. PMID: 30125933.
- Lewis DJ, Hinojosa T, Chan WH, Wu JH, Duvic M. Successful Suppression of Recurrent Zosteriform Mycosis Fungoides With Maintenance Valacyclovir. Actas Dermosifiliogr 109(8):757-760, 2018. e-Pub 2018. PMID: 29499833.
- Lewis DJ, Huang S, Duvic M. Inflammatory cytokines and peripheral mediators in the pathophysiology of pruritus in cutaneous T-cell lymphoma. J Eur Acad Dermatol Venereol 32(10):1652-1656, 2018. e-Pub 2018. PMID: 29775497.
- Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, Whittaker S, Tokura Y, Vermeer M, Zinzani PL, Sokol L, Morris S, Kim EJ, Ortiz-Romero PL, Eradat H, Scarisbrick J, Tsianakas A, Elmets C, Dalle S, Fisher DC, Halwani A, Poligone B, Greer J, Fierro MT, Khot A, Moskowitz AJ, Musiek A, Shustov A, Pro B, Geskin LJ, Dwyer K, Moriya J, Leoni M, Humphrey JS, Hudgens S, Grebennik DO, Tobinai K, Duvic M, MAVORIC Investigators. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial. Lancet Oncol 19(9):1192-1204, 2018. e-Pub 2018. PMID: 30100375.
- Aria AB, Wilmas K, Kim EJ, Aung PP, Duvic M. The development of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder at the site of a melanoma excision scar. Dermatol Online J 24(9), 2018. e-Pub 2018. PMID: 30677830.
- Jensen GL, Dabaja BS, Pinnix CC, Gunther JR, Huen A, Duvic M, Oki Y, Fanale M, Hosing C, Milgrom SA. Radiotherapy in patients with mycosis fungoides and central nervous system involvement. Case Rep Oncol 11(3):721-728, 2018. e-Pub 2018. PMID: 30519174.
- Huang S, Kim EJ, Lewis DJ, Chan WH, Miranda RN, Duvic M. Mycosis fungoides occurring at the site of previous herpes zoster eruption. Australas J Dermatol 59(3):217-219, 2018. e-Pub 2017. PMID: 29280139.
- Lewis DJ, Miranda RN, Oh CW, Hinojosa T, Medeiros LJ, Curry JL, Tetzlaff MT, Torres-Cabala CA, Nagarajan P, Ravandi-Kashani F, Duvic M. Pruritic arthropod bite-like papules in T-cell large granular lymphocytic leukaemia and chronic myelomonocytic leukaemia. Clin Exp Dermatol 43(4):449-453, 2018. e-Pub 2018. PMID: 29423961.
- Gru AA, Kim J, Pulitzer M, Guitart J, Battistella M, Wood GS, Cerroni L, Kempf W, Willemze R, Pawade J, Querfeld C, Schaffer A, Pincus L, Tetzlaff M, Duvic M, Scarisbrick J, Porcu P, Mangold AR, DiCaudo DJ, Shinohara M, Hong EK, Horton B, Kim YH. The Use of Central Pathology Review With Digital Slide Scanning in Advanced-stage Mycosis Fungoides and Sézary Syndrome: A Multi-institutional and International Pathology Study. Am J Surg Pathol 42(6):726-734, 2018. e-Pub 2018. PMID: 29543675.
- Emge DA, Lewis DJ, Aung PP, Duvic M. How to discern folliculotropic mycosis fungoides from follicular mucinosis using a pediatric case. J Cutan Med Surg 22(3):1203475417752366, 2018. e-Pub 2018. PMID: 29318909.
- Duvic M, Bates SE, Piekarz R, Eisch R, Kim YH, Lerner A, Robak T, Samtsov A, Becker JC, McCulloch W, Waksman J, Whittaker S. Responses to Romidepsin in patients with cutaneous T-cell lymphoma and prior treatment with systemic chemotherapy. Leuk Lymphoma 59(4):1-8, 2018. e-Pub 2017. PMID: 28853310.
- Korta DZ, Christiano AM, Bergfeld W, Duvic M, Ellison A, Fu J, Harris JE, Hordinsky MK, King B, Kranz D, Mackay-Wiggan J, McMichael A, Norris DA, Price V, Shapiro J, Atanaskova Mesinkovska N. Alopecia areata is a medical disease. J Am Acad Dermatol 78(4):832-834, 2018. PMID: 29548423.
- Wohlmuth-Wieser I, Osei JS, Norris D, Price V, Hordinsky MK, Christiano A, Duvic M. Childhood Alopecia Areata-Data from the National Alopecia Areata Registry. Pediatr Dermatol 35(2):164-169, 2018. e-Pub 2018. PMID: 29334143.
- Lewis DJ, Kim EJ, Duvic M. Image Gallery: Symmetrical whirled eschars on the face in mycosis fungoides. Br J Dermatol 178(3):e224, 2018. PMID: 29595240.
- Chan WH, Lewis DJ, Kim EJ, Aung PP, Duvic M. Generalized morphea/eosinophilic fasciitis overlap after epoxy exposure. JAAD Case Rep 4(2):175-178, 2018. e-Pub 2018. PMID: 29892660.
- Jour G, Aung PP, Merrill ED, Curry JL, Tetzlaff MT, Nagarajan P, Ivan D, Prieto VG, Duvic M, Miranda RN, Torres-Cabala CA. Differential expression of CCR4 in primary cutaneous gamma/delta (γ/δ) T cell lymphomas and mycosis fungoides: significance for diagnosis and therapy. J Dermatol Sci 89(1):88-91, 2018. e-Pub 2017. PMID: 29030090.
- Lewis DJ, Kim YH, Duvic M. Alternate dosing regimens of brentuximab vedotin for CD30+ cutaneous T-cell lymphoma. Br J Dermatol 178(1):302-303, 2018. e-Pub 2018. PMID: 28889405.
- Lewis DJ, Holder BB, Duvic M. The "Duvic regimen" for erythrodermic flares secondary to Staphylococcus aureus in mycosis fungoides and Sézary syndrome. Int J Dermatol 57(1):123-124, 2018. e-Pub 2017. PMID: 29152728.
- Chan WH, Lewis DJ, Hinojosa T, Curry JL, Duvic M. Juvenile mycosis fungoides with large-cell transformation: Successful treatment with psoralen with ultraviolet A light, interferon-alfa, and localized radiation. Pediatr Dermatol 35(1):e13-e16, 2018. e-Pub 2017. PMID: 29159918.
- Lewis DJ, Duvic M. Important considerations for legislation banning commercial tanning beds among minors. Clin Dermatol 36(1):104-105, 2018. e-Pub 2017. PMID: 29241746.
- Mendoza TR, Osei J, Duvic M. The Utility and Validity of the Alopecia Areata Symptom Impact Scale in Measuring Disease-Related Symptoms and their Effect on Functioning. J Investig Dermatol Symp Proc 19(1):S41-S46, 2018. PMID: 29273105.
- Wilmas K, Aria A, Torres-Cabala CA, Lu H, Duvic M. Schnitzler syndrome in a patient with a family history of monoclonal gammopathy. Dermatol Online J 24(1), 2018. e-Pub 2018. PMID: 29469761.
- Emge DA, Lewis DJ, Aung PP, Duvic M. Eosinophilic infiltrate resembling eosinophilic cellulitis (Wells syndrome) in a patient with mycosis fungoides. Dermatol Online J 24(1), 2018. e-Pub 2018. PMID: 29469767.
- Lewis DJ, Talpur R, Huen AO, Tetzlaff MT, Duvic M. Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results. JAMA Dermatol 153(12):1302-1306, 2017. e-Pub 2017. PMID: 28980004.
- de Jong A, Jabbari A, Dai Z, Xing L, Lee D, Li MM, Duvic M, Hordinsky M, Norris DA, Price V, Mackay-Wiggan J, Clynes R, Christiano AM. High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata. JCI Insight 3(19). e-Pub 2018. PMID: 30282836.
Book Chapters
- Duvic M. Chapter 440: Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases. In: Cecil's Textbook of Internal Medicine. 26th. Elsevier, 2018.
- Duvic, M. Histone Deacetylase Inhibitors for Cutaneous T-Cell Lymphoma. In: Cutaneous Lymphoma. October. Elsevier: New York, 757-764, 2015.
- Pozadzides J, Duvic M, Pro B. Chapter 9: T-cell lymphomas. In: The MD Anderson Manual of Medical Oncology, 3rd Ed. 3rd. McGraw-Hill, 2014.
- Duvic M. Cutaneous T-cell lymphomas: Mycosis fungoides and Sezary syndrome. In: Lymphoma: Diagnosis and Treatment. Springer: New York, 287-329, 2013.
Books (edited and written)
- Vahquist A, Duvic M. Retinoids and Carotenoids in Dermatology. Ed(s) Taylor & Frances. Taylor & Frances, 2007.
- Werth VP, Duvic M. Dermatologic Clinics on Medical Dermatology. WB Saunders, Inc, 2001.