Manickam Muruganandham
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Associate Professor, Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 1999 | University of Delhi, Delhi, IN, Physics (Biomedical MR), Ph.D |
| 1994 | National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, IN, Biophysics, Master of Public Health |
| 1989 | Anna University, College of Engineering / Adyar Cancer Institute, Madras, IN, Medical Physics, M.S |
| 1987 | University of Madras, Madras, IN, Physics, BS |
Postgraduate Training
| 2000-2003 | Research Fellowship, Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York |
Licenses & Certifications
| 2012 | Medical Physicist License awarded by the Texas Medical Board |
| 2011 | American Board of Radiology (ABR) |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 2006 - 2013
Instructor, Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York, 2003 - 2006
Administrative Appointments/Responsibilities
Member, The University of Iowa - Holden Comprehensive Care Center, Iowa City, Iowa, 2007 - 2013
Other Professional Positions
Consultant, Aventis / Regenron Pharmaceuticals DCE-MRI Expert Consensus Meeting, New York, NY, 2004, Regenron Pharmaceuticals, New York, New York, 2004
Medical Physicist, V.N. Cancer Center, GKNM Hospital, Coimbatore, 1989 - 1992
Honors & Awards
| 2002 | International Society for Magnetic Resonance in Medicine (ISMRM) travel award to Honolulu, Hawaii, International Society for Magnetic Resonance in Medicine |
| 1998 | International Society for Magnetic Resonance in Medicine (ISMRM) travel award to Sydney, Australia, International Society for Magnetic Resonance in Medicine |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2013. Breast MRI simulation and Treatment Planning. The Integration of MRI with Radiation Oncology 2013. Conference. The University of Texas MD Anderson Cancer Center – Elekta Phillips MR LINAC consortium meeting, MD Andesron Cancer Center. Houston, TX, US.
Regional Presentations
- 2009. MRI in Radiation Therapy. Siemens Workshop for Oncology Workflow Solutions - Optimizing the Clinical Use of Imaging in Radiation Oncology: VSim, 4D, and MultimodalityProcessing. Conference. University of Iowa – Holden Comprehensive Cancer Center, Center of Excellence in Image-Guided Radiation Therapy, US.
- 2007. Quantitative MR Imaging for Targeting in Radiation Therapy. The Iowa Society of Therapeutic Radiation Oncologists (ISTRO) Annual Conference on Radiation Oncology-2007 at Roy J and Lucille A. Carver College of Medicine. Conference. The University of Iowa. Iowa City, IA, US.
- 2007. MRI in Radiation Therapy. Siemens Workshop on Image Guided Radiation Therapy. Conference. Center of Excellence for Image Guided Radiation Therapy (CEIGRT), Department of Radiation Oncology, University of Iowa Hospitals and Clinics. Iowa City, IA, US.
- 2007. Imaging Tumor Response to Metabolic Oxidative Stress by Magnetic Resonance. Free Radical Science at UIHC Radiation Oncology (Departmental Symposium), Center of Excellence for Image Guided Radiation Therapy (CEIGRT). Conference. Department of Radiation Oncology, University of Iowa Hospitals and Clinics. Iowa City, IA, US.
- 2006. MR Imaging of White Matter Architecture in Relation to Tumor. Center of Excellence for Image Guided Radiation Therapy(CEIGRT),. Conference. Department of Radiation Oncology, University of Iowa Hospitals and Clinics. Iowa City, IA, US.
- 2006. 7.Multi-parametric MRI and MRSI in Radiation Oncology. Conference. The University of Iowa College of Engineering Imaging Group (CEIG). Iowa City, IA, US.
- 2006. 8.Imaging Tumor Response to Metabolic Oxidative Stress by Magnetic Resonance. Center of Excellence for Image Guided Radiation Therapy(CEIGRT),Weekly Translational Research meeting. Conference. Department of Radiation Oncology, University of Iowa Hospitals and Clinics. Iowa City, IA, US.
National Presentations
- 2025. Evaluating the Performance and Limitations of an Automated Treatment Planning Tool for Intact Breast Radiotherapy across Diverse Patient Populations. Poster. 67th AAPM Annual Meeting & Exhibition. Washington, DC, US.
- 2012. Kim Y, Muruganandham M, Flynn R, Modrick J, Jacobson G. MRI Guided, Conformal Brachytherapy for Cervical Cancer, presented at AAPM Spring Clinical Meeting, Dallas, Texas. Conference. Kim Y, Muruganandham M, Flynn R, Modrick J, Jacobson G. MRI Guided, Conformal Brachytherapy for Cervical Cancer, presented at AAPM Spring Clinical Meeting, Dallas, Texas, US.
- 2011. Bhatia SK, Bayouth JE, Muruganandham M. High resolution MRI and PET/CT for precise contouring of gross tumor in rectal cancer. American Radium Society 93rd Annual meeting, West Palm Beach, Florida,. Conference. Bhatia SK, Bayouth JE, Muruganandham M. High resolution MRI and PET/CT for precise contouring of gross tumor in rectal cancer. American Radium Society 93rd Annual meeting, West Palm Beach, Florida,, US.
- 2010. Jacobson GM, Modrick J, Buechler-Price J, Betts V, Muruganandham M, Bayouth J. Comparison of 3D Ultrasound, CT, and MRI for Target Definition in the Post Lumpectomy Breast. American Society for Therapeutic Radiology and Oncology(ASTRO) 52nd Annual Meeting, San Diego CA. Conference. Jacobson GM, Modrick J, Buechler-Price J, Betts V, Muruganandham M, Bayouth J. Comparison of 3D Ultrasound, CT, and MRI for Target Definition in the Post Lumpectomy Breast. American Society for Therapeutic Radiology and Oncology(ASTRO) 52nd Annual Meeting, San Diego CA, US.
- 2009. Kim Y, Muruganandham M, Bayouth JE, Waldron TJ, Modrick JM, Bhatia SK, Jacobson GM. Feasibility of Markers-Catheters for a Titanium Tandem and Ovoids Applicator in MRI Guided Brachytherapy: Implications on Applicator Reconstruction on 3 Tesla MRI. American Brachytherapy Society (ABS) Annual Meeting, Toronto, Ontario, Canada. Conference. Kim Y, Muruganandham M, Bayouth JE, Waldron TJ, Modrick JM, Bhatia SK, Jacobson GM. Feasibility of Markers-Catheters for a Titanium Tandem and Ovoids Applicator in MRI Guided Brachytherapy: Implications on Applicator Reconstruction on 3 Tesla MRI. American Brachytherapy Society (ABS) Annual Meeting, Toronto, Ontario, Canada, US.
- 2008. Bayouth J, Muruganandham M, Duncan C and Gupta A. Accuracy of MRI/CT for immobilized head and neck cancer patients. American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Boston MA,. Conference. Bayouth J, Muruganandham M, Duncan C and Gupta A. Accuracy of MRI/CT for immobilized head and neck cancer patients. American Society for Therapeutic Radiology and Oncology (ASTRO) Annual Meeting, Boston MA,, US.
- 2008. Muruganandham M, Bayouth JE, Smith MC and Buatti JM. Impact of 3 Tesla MR spectroscopic imaging in the delineation of high grade glioma target volumes for radiation therapy planning. American Society for Therapeutic Radiology and Oncology (ASTRO) 50th Annual Meeting, Boston MA,. Conference. Muruganandham M, Bayouth JE, Smith MC and Buatti JM. Impact of 3 Tesla MR spectroscopic imaging in the delineation of high grade glioma target volumes for radiation therapy planning. American Society for Therapeutic Radiology and Oncology (ASTRO) 50th Annual Meeting, Boston MA,, US.
- 2005. Muruganandham M, Lupu M, Dyke JP, Koutcher JA. Application of Dynamic Contrast Enhanced Magnetic Resonance (MR) Imaging in Combination with Lactate-Specific MR Spectroscopy in the Assessment of Breast Tumor Angiogenesis. The 4th Era of Hope meeting for the Department of Defense Breast Cancer Research Program, Philadelphia, PA. Conference. Muruganandham M, Lupu M, Dyke JP, Koutcher JA. Application of Dynamic Contrast Enhanced Magnetic Resonance (MR) Imaging in Combination with Lactate-Specific MR Spectroscopy in the Assessment of Breast Tumor Angiogenesis. The 4th Era of Hope meeting for the Department of Defense Breast Cancer Research Program, Philadelphia, PA, US.
- 2005. Application of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Combination with Lactate-Specific MR Spectroscopy in the Assessment of Breast Tumor Angiogenesis, Diagnostic Molecular Imaging: MR and Nuclear Applications for Improving Breast Cancer Detection and Diagnosis session at the Era of Hope DOD Breast Cancer Research Program’s meeting in Philadelphia, PN. Invited. Application of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Combination with Lactate-Specific MR Spectroscopy in the Assessment of Breast Tumor Angiogenesis, Diagnostic Molecular Imaging: MR and Nuclear Applications for Improving Breast Cancer Detection and Diagnosis session at the Era of Hope DOD Breast Cancer Research Program’s meeting in Philadelphia, PN, US.
- 2002. Towards Absolute Quantification of Lactate Levels in Tumors: NMR Relaxation Measurements of Tumor Lactate In Vivo by Selective Multiple Quantum Coherence Transfer. RAMPS/VACIRCA Young Investigators Symposium, Memorial Sloan-Kettering Cancer Center. Invited. Towards Absolute Quantification of Lactate Levels in Tumors: NMR Relaxation Measurements of Tumor Lactate In Vivo by Selective Multiple Quantum Coherence Transfer. RAMPS/VACIRCA Young Investigators Symposium, Memorial Sloan-Kettering Cancer Center, US.
- 2002. Muruganandham M, Koutcher JA, Quihong He. T2 Mapping of Lactate in Lipid-Rich Environment by Selective Multiple Quantum Coherence Transfer. 43rd Experimental NMR conference, CA. Conference. Muruganandham M, Koutcher JA, Quihong He. T2 Mapping of Lactate in Lipid-Rich Environment by Selective Multiple Quantum Coherence Transfer. 43rd Experimental NMR conference, CA, US.
- 2002. Kalderon N, Muruganandham M, Koutcher J. Allen Revisited: Decompress-Ion is Crucial for Repairing the Contusion-Injured Rat Spinal Cord by Radiation Therapy, Soc. Neuroscience 32nd Annual Meeting, Orlando, FL,. Conference. Kalderon N, Muruganandham M, Koutcher J. Allen Revisited: Decompress-Ion is Crucial for Repairing the Contusion-Injured Rat Spinal Cord by Radiation Therapy, Soc. Neuroscience 32nd Annual Meeting, Orlando, FL,, US.
- 2002. Zakian KL, Sircar K, Kleinman S, Shukla-Dave A, Muruganandham M, Kattan M, Eberhardt S, Reuter V, Scardino P, Hricak H, Koutcher JA. Correlation of Proton MR Spectroscopic Imaging with Gleason Score Based on Step Section Radical Prostatectomy. RSNA 88th Scientific assembly and Annual Meeting, Chicago, IL,. Conference. Zakian KL, Sircar K, Kleinman S, Shukla-Dave A, Muruganandham M, Kattan M, Eberhardt S, Reuter V, Scardino P, Hricak H, Koutcher JA. Correlation of Proton MR Spectroscopic Imaging with Gleason Score Based on Step Section Radical Prostatectomy. RSNA 88th Scientific assembly and Annual Meeting, Chicago, IL,, US.
- 2001. Xu S, Muruganandham M, Koutcher J, Kalderon N. Progression of pathology after contusion injury in rat spinal cord: In vivo MRI studies. Soc, Neurosci. Abstr., Vol. 27, Part 2, P. 2118. Conference. Xu S, Muruganandham M, Koutcher J, Kalderon N. Progression of pathology after contusion injury in rat spinal cord: In vivo MRI studies. Soc, Neurosci. Abstr., Vol. 27, Part 2, P. 2118, US.
- 2000. Applications of Magnetic Resonance Imaging techniques to Monitor the changes in tumor blood flow and oxygenation in animal tumor models. Workshop on MRI & MR Spectroscopy in Pharaceutical and Physiological Research, All India Institute of Medical Sciences, New Delhi. Invited. Applications of Magnetic Resonance Imaging techniques to Monitor the changes in tumor blood flow and oxygenation in animal tumor models. Workshop on MRI & MR Spectroscopy in Pharaceutical and Physiological Research, All India Institute of Medical Sciences, New Delhi, US.
- 1999. Muruganandham M, Jagannathan NR, Jain PC, Jain V. Dynamic Diffusion Weighted MRI to monitor Ca2+ channel blocker-induced changes in Tumor microcirculation. Proc. Intl. Soc. Magn. Reson. Med, 7 pp. 1373. Conference. Muruganandham M, Jagannathan NR, Jain PC, Jain V. Dynamic Diffusion Weighted MRI to monitor Ca2+ channel blocker-induced changes in Tumor microcirculation. Proc. Intl. Soc. Magn. Reson. Med, 7 pp. 1373, US.
- 1998. Muruganandham M, Jagannathan NR, Jain PC, Jain V. Diffusion Weighted MRI to assess changes in Tumor Microcirculation 4th National Magnetic Resonance Society Conference, Bangalore, India. Conference. Muruganandham M, Jagannathan NR, Jain PC, Jain V. Diffusion Weighted MRI to assess changes in Tumor Microcirculation 4th National Magnetic Resonance Society Conference, Bangalore, India, US.
- 1998. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Jain PC, Jain V. Dynamic MRI to monitor Ca2+ Channel blocker-induced changes in Tumor haemodynamics and oxygenation. National Symposium on Radiation and Molecular Biophysics, Bombay, India. Conference. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Jain PC, Jain V. Dynamic MRI to monitor Ca2+ Channel blocker-induced changes in Tumor haemodynamics and oxygenation. National Symposium on Radiation and Molecular Biophysics, Bombay, India, US.
- 1998. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Raghunathan P, Jain PC, Jain V. Bold-MRI observation of Ca2+ channel blocker-induced changes in tumor oxygenation. Proc. Intl.Soc.Magn.Reson.Med, 6 pp. 842. Conference. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Raghunathan P, Jain PC, Jain V. Bold-MRI observation of Ca2+ channel blocker-induced changes in tumor oxygenation. Proc. Intl.Soc.Magn.Reson.Med, 6 pp. 842, US.
- 1997. Tumor Blood Flow Imaging using MRI, Indo-German Workshop on Improving Tumor Radiotherapy, Institute of Nuclear Medicine and Allied Sciences, Delhi, India. Conference. Tumor Blood Flow Imaging using MRI, Indo-German Workshop on Improving Tumor Radiotherapy, Institute of Nuclear Medicine and Allied Sciences, Delhi, India, US.
- 1997. Sharma, RK, Muruganandham M, Raghunathan P, Mitra A, Jain V. 31P MRS Studies on the effects of 2-deoxy-D-glucose (2-DG) pretreatment on the radiation induced changes in a mouse tumor model. 29th Annual Conference of Society of Nuclear Medicine India, Chandigarh, India. Conference. Sharma, RK, Muruganandham M, Raghunathan P, Mitra A, Jain V. 31P MRS Studies on the effects of 2-deoxy-D-glucose (2-DG) pretreatment on the radiation induced changes in a mouse tumor model. 29th Annual Conference of Society of Nuclear Medicine India, Chandigarh, India, US.
- 1997. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Raghunathan P, Jain PC, Jain V. Application of a Fast MRI Sequence to monitor Ca2+ -channel blocker-induced changes in Tumor blood flow. 3rd National Magnetic Resonance Society Conference, New Delhi, India. Conference. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Raghunathan P, Jain PC, Jain V. Application of a Fast MRI Sequence to monitor Ca2+ -channel blocker-induced changes in Tumor blood flow. 3rd National Magnetic Resonance Society Conference, New Delhi, India, US.
- 1997. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Jain PC, Jain V. Effects of Diltiazem on Tumor Vascular Status and Blood Flow: A noninvasive Dynamic contrast enhanced MRI Study. 29th Annual Conference of Society of Nuclear Medicine India, Chandigarh, India,. Conference. Muruganandham M, Kasi Viswanathan A, Jagannathan NR, Jain PC, Jain V. Effects of Diltiazem on Tumor Vascular Status and Blood Flow: A noninvasive Dynamic contrast enhanced MRI Study. 29th Annual Conference of Society of Nuclear Medicine India, Chandigarh, India,, US.
International Presentations
- 2008. Muruganandham M, Bayouth J, Kearney W, Smith M and Buatti J. Integration and verification of 3T magnetic resonance spectroscopic imaging in radiation therapy treatment planning. American Association of Physicists in Medicine (AAPM) 50th Annual Meeting, Houston, TX. Conference. Muruganandham M, Bayouth J, Kearney W, Smith M and Buatti J. Integration and verification of 3T magnetic resonance spectroscopic imaging in radiation therapy treatment planning. American Association of Physicists in Medicine (AAPM) 50th Annual Meeting, Houston, TX, US.
- 2008. Kim Y, Muruganandham M, Bayouth J, Modrick J, Bhatia S and Jacobson G. Evaluation of 3 Tesla image distortion and artifacts in a titanium applicator presence: Toward 3T MRI guided HDR brachytherapy for cervical cancer. American Association of Physicists in Medicine (AAPM) 50th Annual Meeting, Houston, TX. Conference. Kim Y, Muruganandham M, Bayouth J, Modrick J, Bhatia S and Jacobson G. Evaluation of 3 Tesla image distortion and artifacts in a titanium applicator presence: Toward 3T MRI guided HDR brachytherapy for cervical cancer. American Association of Physicists in Medicine (AAPM) 50th Annual Meeting, Houston, TX, US.
- 2005. Muruganandham M, Lupu M, Dyke JP, Matei C, Kolinsky K, Higgins B, Koutcher JA. Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast enhanced MRI at 1.5T. AACR-NCI-EORT International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia PA. Conference. Muruganandham M, Lupu M, Dyke JP, Matei C, Kolinsky K, Higgins B, Koutcher JA. Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast enhanced MRI at 1.5T. AACR-NCI-EORT International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia PA, US.
- 2005. Lockhart AC, Muruganandham M, Schwartz L, Koutcher J, Donnelly E, Andal R, Furfine ES, Chevalier P, Spriggs DR, Rothenberg ML, Cedarbaum JM, Cohen DP, Dupont J. Pharacodynamic Indicators of VEGF Trap Activity in Patients with Advanced Solid Tumors. AACR-NCI-EORTC International Converence on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications. Philadelphia PA. Conference. Lockhart AC, Muruganandham M, Schwartz L, Koutcher J, Donnelly E, Andal R, Furfine ES, Chevalier P, Spriggs DR, Rothenberg ML, Cedarbaum JM, Cohen DP, Dupont J. Pharacodynamic Indicators of VEGF Trap Activity in Patients with Advanced Solid Tumors. AACR-NCI-EORTC International Converence on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications. Philadelphia PA, US.
- 2001. Kalderon N, Xu S, Muruganandham M, Koutcher J. A window of opportunity For treating spinal cord contusion injury as revealed in vivo MRI. 9th International Symposium on Neural Regeneration, Asilomar, CA,. Conference. Kalderon N, Xu S, Muruganandham M, Koutcher J. A window of opportunity For treating spinal cord contusion injury as revealed in vivo MRI. 9th International Symposium on Neural Regeneration, Asilomar, CA,, US.
Formal Peers
- 2006. Functional Imaging of Tumors Using MRI and MRS. Invited. Iowa City, IA, US.
- 2005. Dynamic Contrast Enhanced MRI (DCE-MRI) — A Functional Imaging Tool in Oncology. Department of Radiation Oncology and Molecular Radiation Sciences. Invited. Baltimore, MD, US.
- 2004. 3.Dynamic Contrast Enhanced MRI—a Functional Imaging Tool in Oncology. Molecular Imaging Program in Oncology (MITO). Invited, US.
- 2003. Multi-parametric Magnetic Resonance Imaging of Tumor Angiogenesis. Invited, US.
- 2002. Tumor Lactate Measurements by Magnetic Resonance Spectroscopy. Invited, US.
Grant & Contract Support
| Date: | 2013 - 2014 |
| Title: | MDACC – Elekta Master Research Grant |
| Funding Source: | Elekta |
| Role: | Co-PI |
| Date: | 2010 - 2015 |
| Title: | Quantitative Imaging to Assess Response in Cancer Therapy Trials |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2010 - 2012 |
| Title: | Improving Dosimetric Tumor Coverage and Normal Tissue Sparing in Titanium Brachytherapy for Women’s GYN Cancer Using a high resolution 3 Tesla MR Image and a Hybrid Inverse-Optimization |
| Funding Source: | Varian Medical |
| Role: | Co-I |
| Date: | 2010 |
| Title: | Adaptive Gated RT via Strain Gauge Calibration Against CBCT Projection Data |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 RO1CA148617-01 |
| Date: | 2009 |
| Title: | Integration of MRSI into Radiation Therapy Planning for Brain Tumors |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 RC1 CA144774-01 |
| Date: | 2006 - 2011 |
| Title: | Tumor Hypoxia Imaging – Laboratory and Clinical Studies |
| Funding Source: | NIH/NCI |
| Role: | Co-Program Leader |
| Date: | 1999 - 2005 |
| Title: | Role of imaging in pre-treatment risk assessment of prostate cancer patients |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | NIH ROI-CA 076423 |
Selected Publications
Peer-Reviewed Articles
- Shaitelman, SF, Krishnamurthy, S, Rauch, GM, Lin, Y, Shen, Y, Valero, V, Johnson, HM, Muruganandham, M, Smith, B, Hoffman, K, Lee, B, Shinn, EH, Symmans, WF, Woodward, W, Mitchell, MP, Goodman, C, Buzdar, AU, Singh, P, Tamirisa, N, Kuerer, HM. Definitive, stereotactic ablative radiotherapy and endocrine therapy without surgery for select low-risk breast cancers. Radiotherapy and Oncology 220, 2026. e-Pub 2026. PMID: 42142534.
- Baroudi, H, Che Fru, L, Schofield, D, Roniger, DL, Nguyen, C, Hancock, D, Chung, CV, Beadle, BM, Gifford, KA, Netherton, T, Niedzielski, JS, Melancon, AD, Muruganandham, M, Khan, M, Shaitelman, SF, Shete, S, Murina, P, Venencia, D, Thengumpallil, S, Vrieling, C, Zhang, J, Mitchell, MP, Court, LE. An automated treatment planning portfolio for whole breast radiotherapy. Medical physics 52(3):1779-1788, 2025. e-Pub 2025. PMID: 39699058.
- Shaitelman SF, Le-Petross H, Raso MG, Swanson DM, Schalck AP, Contreras A, Yang F, Muruganandham M, Zhao GZ, Sawakuchi GO, Kim LH, Batra H, Smith BD, Stauder MC, Woodward WA, Reddy JP, Litton JK, Thompson A, Bedrosian I, Mitten EA. PRECISE: Preoperative Radiotherapy to Elicit Critical Immune Stimulating Effects - A Phase II Clinical Trial. Int J Radiat Oncol Biol Phys 121(1):90-96, 2025. e-Pub 2025. PMID: 39147206.
- Gao, S, Muruganandham, M, Du, W, Ohrt, JD, Kudchadker, RJ, Balter, PA. Adding customized electron energy beams to TrueBeam linear accelerators. Journal of applied clinical medical physics 23(7), 2022. e-Pub 2022. PMID: 35533212.
- Netherton T, Li Y, Nitsch P, Shaitelman S, Balter P, Gao S, Klopp A, Muruganandham M, Court L. Interplay effect on a 6-MV flattening-filter-free linear accelerator with high dose rate and fast multi-leaf collimator motion treating breast and lung phantoms. Med Phys 45(6):2369-2376, 2018. e-Pub 2018. PMID: 29611210.
- Muruganandham M, Clerkin PP, Smith BJ, Anderson CM, Morris A, Capizzano AA, Magnotta V, McGuire SM, Smith MC, Bayouth JE, Buatti JM. 3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. Int J Radiat Oncol Biol Phys 90(1):181-9, 2014. e-Pub 2014. PMID: 24986746.
- Schindel J, Muruganandham M, Pigge FC, Anderson J, Kim Y. Magnetic Resonance Imaging (MRI) Markers for MRI-Guided High-Dose-Rate Brachytherapy: Novel Marker-Flange for Cervical Cancer and Marker Catheters for Prostate Cancer. Int J Radiat Oncol Biol Phys 86(2):387-393, 2013. e-Pub 2013. PMID: 23433797.
- Kim Y, Muruganandham M, Modrick JM, Bayouth JE. Evaluation of artifacts and distortions of titanium applicators on 3.0-Tesla MRI: feasibility of titanium applicators in MRI-guided brachytherapy for gynecological cancer. Int J Radiat Oncol Biol Phys 80(3):947-55, 2011. e-Pub 2011. PMID: 20934275.
- Jacobson G, Zamba G, Betts V, Muruganandham M, Buechler-Price J. Image-Based Treatment Planning of the Post-Lumpectomy Breast Utilizing CT and 3TMRI. Int J Breast Cancer 2011:246265, 2011. e-Pub 2011. PMID: 22295215.
- Kalderon N, Muruganandham M, Koutcher JA, Potuzak M. Therapeutic strategy for acute spinal cord contusion injury: cell elimination combined with microsurgical intervention. PLoS One 2(6):e565, 2007. e-Pub 2007. PMID: 17637827.
- Muruganandham M, Lupu M, Dyke JP, Matei C, Linn M, Packman K, Kolinsky K, Higgins B, Koutcher JA. Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T. Mol Cancer Ther 5(8):1950-7, 2006. e-Pub 2006. PMID: 16928815.
- Muruganandham M, Alfieri AA, Matei C, Chen Y, Sukenick G, Schemainda I, Hasmann M, Saltz LB, Koutcher JA. Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy. Clin Cancer Res 11(9):3503-13, 2005. e-Pub 2005. PMID: 15867253.
- Zakian KL, Sircar K, Hricak H, Chen HN, Shukla-Dave A, Eberhardt S, Muruganandham M, Ebora L, Kattan MW, Reuter VE, Scardino PT, Koutcher JA. Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy. Radiology 234(3):804-14, 2005. e-Pub 2005. PMID: 15734935.
- Muruganandham M, Koutcher JA, Pizzorno G, He Q. In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer. Magn Reson Med 52(4):902-6, 2004. e-Pub 2004. PMID: 15389963.
- Shukla-Dave A, Hricak H, Eberhardt SC, Olgac S, Muruganandham M, Scardino PT, Reuter VE, Koutcher JA, Zakian KL. Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings--initial observations. Radiology 231(3):717-24, 2004. e-Pub 2004. PMID: 15163811.
- Zakian KL, Eberhardt S, Hricak H, Shukla-Dave A, Kleinman S, Muruganandham M, Sircar K, Kattan MW, Reuter VE, Scardino PT, Koutcher JA. Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results. Radiology 229(1):241-7, 2003. e-Pub 2003. PMID: 12920178.
- Muruganandham M, Kasiviswanathan A, Jagannathan NR, Raghunathan P, Jain PC, Jain V. Diltiazem enhances tumor blood flow: MRI study in a murine tumor. Int J Radiat Oncol Biol Phys 43(2):413-21, 1999. e-Pub 1999. PMID: 10030270.
- Sreenivasan R, Muruganandham M, Sharma M, Joshi PG, Joshi NB. Binding of monomeric and oligomeric porphyrins to human glioblastoma (U-87MG) cells and their photosensitivity. Cancer Lett 120(1):45-51, 1997. e-Pub 1997. PMID: 9570385.
Invited Articles
- Bayouth JE, Casavant TL, Graham MM, Sonka M, Muruganandham M, Buatti JM. Image-based biomarkers in clinical practice. Semin Radiat Oncol 21(2):157-66, 2011. e-Pub 2011. PMID: 21356483.
Other Articles
- Muruganandham M, Che Fru L, Baroudi H, Evans S, Nguyen C, Netherton T, Afifi S, Gifford KA, Niedzielski JS, Melancon A, Mohamad I, Shaitelman SF, Shaw W, Shete S, Shulman A, Smith B, Murina P, Venencia D, Thengumpallil S, Vrieling C, Mitchell MP, Court LE, Schofield D Evaluating the Performance and Limitations of an Automated Treatment Planning Tool for Intact Breast Radiotherapy Across Diverse Patient Population.
- Muruganandham M, Dynamic JV MRI in assessing Tumor Blood Flow and Oxygenation. Current Science, 1999.
Abstracts
- Jacobson GM, Modrick J, Buechler-Price J, Betts V, Muruganandham M, Bayouth JE. Comparison of 3D Ultrasound, CT, and MRI for Target Definition in the Post Lumpectomy Breast. (Abst) Int. J Rad Oncol Biol Phys 78(3), pp S217. International Journal of Radiation Oncology, Biology, Physics 78(3):S217-S218, 2010. e-Pub 2010.
- Buechler-Price J, Betts V, Muruganandham M, Zamba G, Jacobson G. Image-based Treatment Planning of the Post-lumpectomy Breast Utilizing CT and 3T MRI. (Abst) Int. J Rad Oncol Biol Phys , 75(3) , pp S209, 2009. e-Pub 2009.
- Kim Y, Muruganandham M, Bayouth JE, Waldron TJ, Modrick JM, Bhatia SK, Jacobson GM. Feasibility of marker-catheters for a titanium tandem and ovoids applicator in MRI-guided bracytherapy: Implications on applicator reconstruction on 3 Tesla MRI. (Abst). Brachytherapy, 8(2), pp 121, 2009. e-Pub 2009.
- Muruganandham M, Bayouth JE, Smith MC, Buatti JM. Metabolic Changes in Malignant Brain Tumors During Mid-Course Radiation Therapy: Initial Findings of 3 Tesla Volumetric Magnetic Resonance Spectroscopic Imaging. (Abst). Medical Physics 36(6): pp2705-2706, 2009. e-Pub 2009.
- Muruganandham M, Bayouth JE, Anderson CM, Smith MC, Buatti JM. 3D-MR Spectroscopic Imaging Assessment of Metabolic Status of Malignant Gliomas during External Beam Radiation Therapy - Preliminary Results. (Abst). Int. J Rad Oncol Biol Phys, 2008. e-Pub 2008.
- Muruganandham M, Bayouth JE, Kearney WM, Smith MC, Buatti JM. Integration and verification of 3T magnetic resonance spectroscopic imaging in radiation therapy treatment planning. (Abst) Medical Physics 35(6):pp 2704, 2008. e-Pub 2008.
- Bayouth JE, Muruganandham M, Duncan C, Gupta A. Accuracy of MRI/CT for immobilized head and neck cancer patients. (Abst). Int. J Rad Oncol Biol Phys , 72(1) , pp S593 - S593, 2008. e-Pub 2008.
- Muruganandham M, Bayouth JE, Smith MC, Buatti JM. Impact of 3 Tesla MR spectroscopic imaging in the delineation of high grade glioma target volumes for radiation therapy planning.(Abst). Int. J Rad Oncol Biol Phys , 72(1) , pp S210 – S210, 2008. e-Pub 2008.
- Kim Y, Muruganandham M, Bayouth JE, Modrick JM, Bhatia SK, Jacobson GM. Evaluation of 3 Tesla image distortion and artifacts in a titanium applicator presence: Toward 3T MRI guided HDR Brach therapy for cervical cancer. (Abst) Medical Physics 35(6): pp 2970, 2008. e-Pub 2008.
- Murganandham M, Schwartz LH, Kemeny NE, Jarnagin WR, Haviland D, Dyke JP, Koutcher JA. DCE-MRI Assessment of Hepatic Arterial Infusion Chemotherapy in Patients with Unresectable Primary Liver Cancer. Proc. Intl Soc Magn Reson Med 13, 2005. e-Pub 2005.
- Danso M, Jarnagin WR, Muruganandham M, Schwartz LH, Goen M, Haviland D, Blumgart L, D’Angelica MD, Dematteo R, Kemeny N. Hepatic Arterial infusion therapy in patients with unresectable primary liver cancer. Use of dynamic contrast enhanced MRI to evaluate response. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, No16S 2005: 4129, 2005. e-Pub 2005.
- Muruganandham M, Lupu M, Dyke JP, Matei C, Higgins B, Kolinsky K, Bachynsky M, Grace JU, Koutcher JA. Preclinical Evaluation of Anti- angiogenic agent Roche I by Dynamic Contrast Enhanced MRI at 1.5T. Proc. Intl Soc Magn Reson Med 12,, 2004. e-Pub 2004.
- Shukla-Dave JA, Koutcher JA, Eberhardt S, Muruganandham M, Sircar K, Scardino P, Rueter V, Hricak H, Zakian KL. 1H MRSI findings in prostatitis. Proc. Intl. Soc. Mag. Reson. Med. 11, 2003. e-Pub 2003.
- Muruganandham M, XuS, Kalderon N, KoutcherJ. MRI Evaluation of the onset of chronic inflammation after contusion injury in rat spinal cord. Proc. Intl. Soc. Mag. Reson. Med.10, 2002. e-Pub 2002.
- Muruganandham M, Koutcher JA, He Q. T2 Relaxation measurements of Lactate in abundant Lipid Environment by Selective Multiple Quantum Coherence Transfer, Proc. Intl. Soc. Mag. Reson. Med 10, 2002. e-Pub 2002.
- Muruganandham M, Chen Y, Scheminda I, Hasmann H, Saltz L, Koutcher JA. The Effects of FK866 on Tumor Metabolism and Growth: 1H-decoupled 31P MRS Study. Proc. Intl. Soc. Mag. Reson. Med.10, 2002. e-Pub 2002.
- Zakian KL, Eberhardt S, Kleinman S, Shukla-Dave A, Muruganandham M Rueter V, Scardino P, Hricak H, Koutcher JA. The Utility of 1H MRSI in Detecting Cancer in the Prostate Transition Zone. Proc. Intl. Soc. Mag. Reson. Med.10, 2002. e-Pub 2002.
Book Chapters
- Murganandham M, Koutcher. In: Magnetic Resonance Imaging in Mouse Cancer Models. Mouse Models of Human Cancer, 2004.
- Muruganandham M, Jain V. In: Applications of Magnetic Resonance Imaging Techniques to Monitor the Changes in Tumor Blood Flow and Oxygenation in Animal Tumor Models pp. 97-111. NR Jagannathan, JAYPEE Medical Publishers (p) Ltd, New Delhi, 2001.
Patient Reviews
CV information above last modified July 22, 2026