Manjunath Nimmakayalu, Ph.D.
School of Health Professions, Division of Education & Training
Present Title & Affiliation
Primary Appointment
Assistant Professor, School of Health Professions, Division of Diagnostic Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1994 | Bangalore University, Bangalore, IND, PHD, Human Genetics |
Postgraduate Training
| 1998-2002 | Post Doctoral Training, Human Molecular Genetics, Yale University, School of Medicine, New Haven, CT |
| 1994-1996 | Research Fellowship, Human Molecular Genetics, Institut fur Human Genetik, Gottingen |
Board Certifications
| 2012 | American Society of Clinical Pathology (CG) |
Experience & Service
Institutional Committee Activities
Teaching faculty, Duke TIP Scholar Summer workshop, 2020 - Present
Member, CCSG Career Enhancement Travel Award, 2020 - Present
Member, MS thesis committee for Cytogenetics and Cytogenomics track, 2020 - Present
Member, Diagnostic Genetics and Genomics Advisory Committee, 2019 - Present
Member, SHP Scholarship application review committee, 2019 - Present
Member, Diagnostic Genetics - Education coordinator interview committee, 2019 - Present
Member, King Foundation High School Summer Program, 2019 - Present
Member, Diagnostic Genetics and Genomics – Admissions committee, 2019 - Present
Member, King Foundation High School Applicant Review committee, 2019 - Present
Member, Cytogenetic Technology (CGT) Admissions committee, 2019 - Present
Member, School of Health professions -Academic standing Committee, 2019 - Present
Member, Cytogenetic Technology (CGT) Advisory committee, 2018 - Present
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Nimmakayalu M, Horton VK, Darbro B, Patil SR, Alsayouf H, Keppler-Noreuil K, Shchelochkov OA. Apparent germline mosaicism for a novel 19p13.13 deletion disrupting NFIX and CACNA1A. Am J Med Genet A 161A(5):1105-9, 2013. e-Pub 2013. PMID: 23495138.
- Nimmakayalu M, Noble N, Horton VK, Willing M, Copeland S, Sheffield V, Nagy PL, Wassink T, Patil S, Shchelochkov OA. 2q24 deletions: further characterization of clinical findings and their relation to the SCN cluster. Am J Med Genet A 158A(11):2767-74, 2012. e-Pub 2012. PMID: 23023937.
- Cyr AB, Nimmakayalu M, Longmuir SQ, Patil SR, Keppler-Noreuil KM, Shchelochkov OA. A novel 4p16.3 microduplication distal to WHSC1 and WHSC2 characterized by oligonucleotide array with new phenotypic features. Am J Med Genet A 155A(9):2224-8, 2011. e-Pub 2011. PMID: 21815251.
- Nimmakayalu M, Major H, Sheffield V, Solomon DH, Smith RJ, Patil SR, Shchelochkov OA. Microdeletion of 17q22q23.2 encompassing TBX2 and TBX4 in a patient with congenital microcephaly, thyroid duct cyst, sensorineural hearing loss, and pulmonary hypertension. Am J Med Genet A 155A(2):418-23, 2011. e-Pub 2011. PMID: 21271665.
- Li MM, Nimmakayalu MA, Mercer D, Andersson HC, Emanuel BS. Characterization of a cryptic 3.3 Mb deletion in a patient with a "balanced t(15;22) translocation" using high density oligo array CGH and gene expression arrays. Am J Med Genet A 146A(3):368-75, 2008. PMID: 18203177.
- Gotter AL, Nimmakayalu MA, Jalali GR, Hacker AM, Vorstman J, Conforto Duffy D, Medne L, Emanuel BS. A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies. Genome Res 17(4):470-81, 2007. e-Pub 2007. PMID: 17351131.
- Shaikh TH, O'Connor RJ, Pierpont ME, McGrath J, Hacker AM, Nimmakayalu M, Geiger E, Emanuel BS, Saitta SC. Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms. Genome Res 17(4):482-91, 2007. e-Pub 2007. PMID: 17351135.
- Li P, Zhang HZ, Huff S, Nimmakayalu M, Qumsiyeh M, Yu J, Szekely A, Xu T, Pober BR. Karyotype-phenotype insights from 11q14.1-q23.2 interstitial deletions: FZD4 haploinsufficiency and exudative vitreoretinopathy in a patient with a complex chromosome rearrangement. Am J Med Genet A 140(24):2721-9, 2006. PMID: 17103440.
- Ming JE, Geiger E, James AC, Ciprero KL, Nimmakayalu M, Zhang Y, Huang A, Vaddi M, Rappaport E, Zackai EH, Shaikh TH. Rapid detection of submicroscopic chromosomal rearrangements in children with multiple congenital anomalies using high density oligonucleotide arrays. Hum Mutat 27(5):467-73, 2006. PMID: 16619270.
- Zhang HZ, Li P, Wang D, Huff S, Nimmakayalu M, Qumsiyeh M, Pober BR. FOXC1 gene deletion is associated with eye anomalies in ring chromosome 6. Am J Med Genet A 124A(3):280-7, 2004. PMID: 14708101.
- Nimmakayalu MA, Gotter AL, Shaikh TH, Emanuel BS. A novel sequence-based approach to localize translocation breakpoints identifies the molecular basis of a t(4;22). Hum Mol Genet 12(21):2817-25, 2003. e-Pub 2003. PMID: 12952865.
- Hui P, Howe JG, Crouch J, Nimmakayalu M, Qumsiyeh MB, Tallini G, Flynn SD, Smith BR. Real-time quantitative RT-PCR of cyclin D1 mRNA in mantle cell lymphoma: comparison with FISH and immunohistochemistry. Leuk Lymphoma 44(8):1385-94, 2003. PMID: 12952233.
- Kone J, Arroyo J, Savinelli T, Lin S, Boyd K, Wu Y, Nimmakayalu M, Copeland NG, Jenkins NA, Qumsiyeh M, Hu P, Prescott A, Wu H, Yang L, Roe B, Perkins AS. F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4. Leukemia 16(9):1827-34, 2002. PMID: 12200699.
- Stankiewicz P, Rujner J, Löffler C, Krüger A, Nimmakayalu M, Pilacik B, Krajewska-Walasek M, Gutkowska A, Hansmann I, Giannakudis I. Alagille syndrome associated with a paracentric inversion 20p12.2p13 disrupting the JAG1 gene. Am J Med Genet 103(2):166-71, 2001. PMID: 11568926.
- Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SA, Gallagher PG. Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Gene 261(2):365-72, 2000. PMID: 11167025.
- Yang YH, Chen YH, Zhang CY, Nimmakayalu MA, Ward DC, Weissman S. Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69(3):355-69, 2000. PMID: 11056054.
- Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology 32(1):11-6, 2000. PMID: 10869283.
- Nimmakayalu M, Henegariu O, Ward DC, Bray-Ward P. Simple method for preparation of fluor/hapten-labeled dUTP. Biotechniques 28(3):518-22, 2000. PMID: 10723566.
- Cremona O, Nimmakayalu M, Haffner C, Bray-Ward P, Ward DC, De Camilli P. Assignment of SYNJ1 to human chromosome 21q22.2 and Synj12 to the murine homologous region on chromosome 16C3-4 by in situ hybridization. Cytogenet Cell Genet 88(1-2):89-90, 2000. PMID: 10773674.
- Ghosh B, Jacobs HC, Wiedemann LM, Brown A, Bedford FK, Nimmakayalu MA, Ward DC, Bogue CW. Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex. Mamm Genome 10(10):1023-5, 1999. PMID: 10501975.
- Cao D, Nimmakayalu MA, Wang F, Zhang D, Handschumacher RE, Bray-Ward P, Pizzorno G. Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. Cancer Res 59(19):4997-5001, 1999. PMID: 10519414.
- Wang, H., Chatterjee, G., Meyer, J.J., Liu, C-J., M.A. Nimmakayalu., Bray-Ward, P. and Langeyel,. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b and Ifi202c) from the murine interferon – activatable gene cluster. Genomics 60(3):281-294, 1999. PMID: 10493828.
- Manjunath, N.A, Bray-Ward, P., Goldstein, S.A.N. and Gallagher, P.G.. Assignment of the 2P domain, acid-sensitive potassium channel OAT1 gene KCNK3 to human chromosome bands 2p24.1-->p23.3 and murine 5B by in situ hybridization. Cytogenetics and Cell Genetics 86(3-4):242-3, 1999. PMID: 10575216.
- Jacob A.N.K, Manjunath N.A., Bray-Ward, P., and Khandpal, R P.. Molecular Cloning of a Zinc finger gene eZNF from Human Inner Ear cDNA library and in-situ expression of its mouse homologue in mouse ear. Somat Cell Mol Genetics 24(2):121-129, 1998. PMID: 9919311.
Abstracts
- MA Nimmakayalu, BS Emanuel, VS Tonk, GVN Velagaleti. Pericentric inv (22): Another low copy repeats (LCR) mediated recurrent abnormality?. Cytogenetics and Genome research 106(1):131-131, 2004.
- Nimmakayalu, A.L. Gotter and B.S. Emanuel.. Analysis of a translocation breakpoint by FISH and PRINS: a molecular cytogenetic approach. American Journal of Human Genetics 73(5):306-306, 2003.
- J. Ganesh, M.K. Maisenbacher, L. Medne, E.C. Moore, M. Nimmakayalu, T. Moshang, E.H. Zackai, N.B. Spinner. Phenotypic and Molecular characterization of distal 19q trisomy detected by FISH. American Journal of Human Genetics 73(5):289-289, 2003.
- MA Nimmakayalu, O Henegariu, P Bray-Ward, DC Ward. A simple fluornucleotide coupling method for M-FISH analysis of patients associated with MR and Autism. American Journal of Human Genetics 65(4):A-352, 1999.
Book Chapters
- Verma, I.C., Sharma, V., Sarkar, T.S., Kabra, M., Arya, L.S., and Manjunath, N.A.. Genetics studies of Retinoblastoma in India. In: Familial cancer and prevention: Molecular Epidemiology: A New strategy toward Cancer Control. Edited by. Wiley –Liss: USA, 485-491, 1999.
- Thomas, I.M., Hegde, S., Tilak, P., Lincoln, S., Reddy, K.S., Manjunath, N.A.. Chromosomal Syndromes in Mental retardation. In: Role Of Genetics in Mental Retardation. Synergy Pub: India, 1998.
Patient Reviews
CV information above last modified August 15, 2023