Manu M. Sebastian, DVM, PhD
Department of Veterinary Medicine and Surgery, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Veterinary Medicine and Surgery, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, Department of Livestrong Cancer Institute, UT Austin, Austin, TX
Faculty member, Dell Medical School, Austin, TX
Education & Training
Degree-Granting Education
| 2004 | University of Kentucky, Lexington, Kentucky, US, Veterinary Pathology, PhD |
| 1993 | College of Veterinary Science, Kerala , India, Kerala, IN, Veterinary Pathology, MS |
| 1990 | College of Veterinary Science, Kerala, India, Kerala, IN, Veterinary Medicine, DVM |
Postgraduate Training
| 1999-2002 | Residency in Veterinary Pathology, University of Kentucky, Lexington, Kentucky |
Board Certifications
| 2019 | Fellow, International Academy of Toxicologic Pathology |
| 2011 | Diplomate, American College of Laboratory Animal Medicine |
| 2007 | Diplomate, American Board of Toxicology |
| 2006 | Diplomate, American College of Veterinary Pathology |
Experience & Service
Academic Appointments
Associate Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - 2023
Associate Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - 2023
Assistant Professor, Department of College of Veterinary Medicine, Cornell University, Ithaca, NY, 2018 - 2021
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 2016 - 2021
Adjunct Assistant Professor, Department of College of Veterinary Medicine, Cornell University, Ithaca, NY, 2008 - 2016
Assistant Professor of Clinical Pathology, Department of Dept of Pathology, College of Physicians & Surgeons, Columbia University, New York, NY, 2007 - 2010
Assistant Professor of Pathology, Chief of University Toxicology Testing, University of Georgia, Athens, GA, 2004 - 2007
Assistant Professor, Department of Pathology, College of Veterinary Science Trichur, Kerala, 1994 - 1999
Other Appointments/Responsibilities
Member, Advisory Board, AuraVax, Houston, Texas, 2021 - Present
Advisory Board, Clarapath, Hawthorne, NY, 2021 - Present
Member, Advisory Board, PathPresenter, NY, 2020 - Present
Member, Medical Advisory Board, Optrascan, California, 2019 - 2021
Advisor, UT Austin, Texas Health Catalyst, Austin, 2019 - Present
Member, MDACC Faculty Senate, Houston, TX, 2017 - 2021
Director, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Smithville, TX, 2016 - 2021
Associate Director, Non Clinical Development, Soligenix, Princeton, NJ, 2015 - 2016
Ad Hoc Member/Site Visitor, AAALAC International, Frederick, MD, 2012 - 2018
Pathology Section Supervisor, Experimur, Chicago, IL, 2011 - 2014
Member, University Of Texas Graduate School of Biomedical Sciences, Houston, TX, 2010 - Present
Member, Medical Advisory Board, Women at Risk (Non-Profit organization for breast cancer research and prevention), New York, NY, 2009 - 2010
Member, Stem Cell Consortium, Columbia University, New York, NY, 2008 - 2010
Member, Control Substance Working Group, Columbia University, New York, NY, 2008 - 2010
Member, Institutional Health & Safety Council, Columbia University, New York, NY, 2008 - 2009
Chief of Comparative Pathology, Columbia University, New York, NY, 2007 - 2010
Diagnostic Pathologist, University of Kentucky, Lexington, KY, 2002 - 2004
Institutional Committee Activities
Member, MDACC Institutional Digital Pathology Working Group, 2021 - Present
Member, MDACC Institutional Animal Care & Use Committee, 2019 - 2021
Honors & Awards
| 2009 | Best Publication Award in "Veterinary Pathology", CL Davis Foundation |
| 2005 | Young Investigator Award, American College of Veterinary Pathology |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Leekha A, Saeedi A, Kumar M, Sefat KMSR, Martinez-Paniagua M, Meng H, Fathi M, Kulkarni R, Reichel K, Biswas S, Tsitoura D, Liu X, Cooper LJN, Sands CM, Das VE, Sebastian M, Hurst BL, Varadarajan N. An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models. Nat Commun 15(1):6053, 2024. e-Pub 2024. PMID: 39025863.
- Wright, T, Wang, Y, Stratton, SA, Sebastian, MM, Liu, B, Johnson, DG, Bedford, MT. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma. Biochemical Journal 148(22):1805-1816, 2023. e-Pub 2023. PMID: 37905668.
- Ghosh S, Fan F, Powell RT, Roszik J, Park YS, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya R. Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer. Mol Cancer Ther 22(8):962-975, 2023. e-Pub 2023. PMID: 37310170.
- Liu Y, Ahumada AL, Bayraktar E, Schwartz P, Chowdhury M, Shi S, Sebastian M, Khant H, de Val N, Bayram NN, Zhang G, Vu TC, Jie Z, Jennings NB, Rodriguez-Aguayo C, Swain J, Stur E, Mangala LS, Wu Y, Nagaraju S, Ermias B, Li C, Lopez-Berestein G, Braam J, Sood AK. Enhancing oral delivery of plant-derived vesicles for colitis. J Control Release 357:472-483, 2023. e-Pub 2023. PMID: 37031740.
- Fontes, F, Rocha, S, Sánchez, R, Pessina, P, Sebastian, MM, Benavides, FJ, Breijo, M. Detection of high antibodies titers against rat leukemia virus in an outbreak of reproductive disorders and lymphomas in Wistar rats. Laboratory Animals 56(5):437-445, 2022. e-Pub 2022. PMID: 35360996.
- Zhao S, Goewey Ruiz JA, Sebastian M, Kidane D. Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response. Front Immunol 13:1039009, 2022. e-Pub 2022. PMID: 36624848.
- Wurster JI, Peterson RL, Brown CE, Penumutchu S, Guzior DV, Neugebauer K, Sano WH, Sebastian M, Quinn RA, Belenky P. Streptozotocin-induced hyperglycemia alters the cecal metabolome and exacerbates antibiotic-induced dysbiosis. Cell Rep 37(11):110113, 2021. e-Pub 2021. PMID: 34910917.
- Yang F, Chen J, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. SPINDOC binds PARP1 to facilitate PARylation. Nat Commun 12(1):6362, 2021. e-Pub 2021. PMID: 34737271.
- Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Sebastian M, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun 12(1):5389, 2021. e-Pub 2021. PMID: 34508101.
- Kos, Z, Roblin, E, Kim, RS, Michiels, S, Gallas, BD, Chen, W, Van De Vijver, K, Goel, S, Adams, S, Demaria, S, Viale, G, Nielsen, TO, Badve, S, Symmans, WF, Sotiriou, C, Rimm, DL, Hewitt, SM, Denkert, C, Loibl, S, Luen, SJ, Bartlett, JM, Savas, P, Pruneri, G, Dillon, D, Cheang, M, Tutt, A, Hall, JA, Kok, M, Horlings, HM, Madabhushi, A, van der Laak, J, Ciompi, F, Lænkholm, AV, Bellolio, E, Gruosso, T, Fox, SB, Araya O, JC, Floris, G, Hudeček, J, Voorwerk, L, Beck, AH, Kerner, J, Larsimont, D, Declercq, S, Van Den Eynden, GG, Pusztai, L, Yang, W, Yuan, Y, Lazar, A, Sebastian, MM. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer. npj Breast Cancer 6(1), 2020. e-Pub 2020. PMID: 32411819.
- Davis JS, Kanikarla-Marie P, Gagea M, Yu PL, Fang D, Sebastian M, Yang P, Hawk E, Dashwood R, Lichtenberger LM, Menter D, Kopetz S. Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development. BMC Cancer 20(1):871, 2020. e-Pub 2020. PMID: 32912193.
- Turner OC, Aeffner F, Bangari DS, High W, Knight B, Forest T, Cossic B, Himmel LE, Rudmann DG, Bawa B, Muthuswamy A, Aina OH, Edmondson EF, Saravanan C, Brown DL, Sing T, Sebastian M. Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathology. Toxicol Pathol 48(2):192623319881401, 2020. e-Pub 2020. PMID: 31645203.
- Zhao S, Klattenhoff AW, Thakur M, Sebastian M, Kidane D. Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice. Cancers (Basel) 11(8), 2019. e-Pub 2019. PMID: 31412651.
- Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian M, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology 157(1):163-178, 2019. e-Pub 2019. PMID: 30885780.
- Bao J, Di Lorenzo A, Lin K, Lu Y, Zhong Y, Sebastian M, Muller WJ, Yang Y, Bedford MT. Mouse models of overexpression reveal distinct oncogenic roles for different type I protein arginine methyltransferases. Cancer Res 79(1):21-32, 2019. e-Pub 2019. PMID: 30352814.
- McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies. Front Oncol 9(JUN):517, 2019. e-Pub 2019. PMID: 31275852.
- Bartkowiak T, Jaiswal AR, Ager CR, Chin R, Chen CH, Budhani P, Ai M, Reilley MJ, Sebastian M, Hong DS, Curran MA. Activation of 4-1BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway. Clin Cancer Res 24(5):1138-1151, 2018. e-Pub 2018. PMID: 29301830.
- Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, Sebastian M, Pugsley MK, Wong K, Authier S. Citrulline as a biomarker for gastrointestinal-acute radiation syndrome: Species differences and experimental condition effects. Radiat Res 186(1):71-8, 2016. e-Pub 2016.
- Lifante JC, Milone L, Korner J, Kopsombut G, Sebastian M, Inabnet WB. Sleeve gastrectomy improves glucose homeostasis in Zucker diabetic fatty rats. Obes Surg 22(7):1110-6, 2012. e-Pub 2012. PMID: 22555866.
- Kopsombut G, Shoulson R, Milone L, Korner J, Lifante JC, Sebastian M, Inabnet WB. Partial small bowel resection with sleeve gastrectomy increases adiponectin levels and improves glucose homeostasis in obese rodents with type 2 diabetes. World J Surg 36(6):1432-8, 2012. e-Pub 2012. PMID: 22362044.
- Sonabend AM, Stuart RM, Yun J, Yanagihara T, Mohajed H, Dashnaw S, Bruce SS, Brown T, Romanov A, Sebastian M, Arias-Mendoza F, Bagiella E, Canoll P, Bruce JN. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol 13(8):886-93, 2011. e-Pub 2011. PMID: 21750007.
- Bernard, WV, Sebastian, MM, Hemming, B. Salmonella Antimicrobial Activity of Selected Strains of Enterolactobacillus Species Isolated from the Gastrointestinal Tract of the Horse. Journal of Equine Veterinary Science 31(7):396-399, 2011. e-Pub 2011.
- Inabnet WB, Milone L, Harris P, Durak E, Freeby MJ, Ahmed L, Sebastian MM, Lifante JC, Bessler M, Korner J. The utility of [(11)C] dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass. Surgery 147(2):303-9, 2010. e-Pub 2010. PMID: 19828168.
- Scherzer J, Sebastian M, Davis C, Ensley D, Hurley D. Clinical observation on differential effects of the trace elements selenium and copper during bovine embryo transfer. Bovine Practioner 43(2):160-7, 2009. e-Pub 2009.
- Sebastian, MM, Giles, RC, Donahu, JM, Sells, S, Fallon, L, Vickers, ML. Dermatophilus congolensis-associated placentitis, funisitis and abortion in a horse. Transboundary and Emerging Diseases 55(3-4):183-185, 2008. e-Pub 2008. PMID: 18405341.
- Sebastian, MM, Stewart, I, Williams, NM, Poonacha, KB, Sells, S, Vickers, ML, Harrison, L. Pathological, entomological, avian and meteorological investigation of a West nile virus epidemic in a horse farm. Transboundary and Emerging Diseases 55(2):134-139, 2008. e-Pub 2008. PMID: 18397501.
- Sebastian MM, Bernard W, Riddle T, Latimer C, Fitzgerald TD, Harrison LR. Mare Reproductive Loss Syndrome-A Review (Cover Page Review). Veterinary Pathology 45:710-22, 2008. e-Pub 2008.
- Sebastian, MM, Giles, RC, Roberts, J, Poonacha, KB, Harrison, L, Donahue, JM, Benirschke, K. Funisitis associated with leptospiral abortion in an equine placenta. Veterinary pathology 42(5):659-662, 2005. e-Pub 2005. PMID: 16145212.
- Bolin DC, Donahue JM, Vickers ML, Harrison L, Sells S, Giles RC, Hong CB, Poonacha KB, Roberts J, Sebastian MM, Swerczek TW, Tramontin R, Williams NM. Microbiologic and pathologic findings in an epidemic of equine pericarditis. J Vet Diagn Invest 17(1):38-44, 2005. e-Pub 2005. PMID: 15690949.
- Flaminio JBF, Nydam DV, Sebastian M, Bernard WV, Tobin T, Hillegas JM, Matychak MB. The Mare Reproductive Loss Syndrome (MRLS) and the Eastern Tent Caterpillar: Immunological Testing of Aborting Mares. International Journal of Applied Research in Veterinary Medicine 3:207-16, 2005. e-Pub 2005.
- Sebastian MM, Giles RC, Roberts JF, Poonacha KB, Donahue JM, Harrison LR, Benirschke K. Funisitis associated with leptospiral abortion in an equine placenta. Veterinary Pathology 42:659-62, 2005. e-Pub 2005.
- Bolin DC, Donahue JM, Vickers ML, Giles RC, Harrison L, Jackson C, Poonacha KB, Roberts JE, Sebastian MM, Sells SE, Tramontin R, Williams NM. Equine abortion and premature birth associated with Cellulosimicrobium cellulans infection. J Vet Diagn Invest 16(4):333-6, 2004. e-Pub 2004. PMID: 15305747.
- Sebastian MM, Giles RC. Fibrocartilaginous embolic myelopathy in a horse. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine 51(7-8):341-343, 2004. e-Pub 2004. PMID: 15533115.
- Sebastian MM, Giles RC. Myelopathy associated with fibrocartilagenous emboli in a horse. Journal of Veterinary Medicine, Series 1 51:1-3, 2004. e-Pub 2004.
- Sebastian MM, Gantz M, Tobin T, Harkins J, Bosken J, Hughes C, Harrison L, Bernard WV, Richter D, Fitzgerald TD. The mare reproductive loss syndrome and the eastern Tent Caterpillar. Veterinary Therapeutics 4(4), 2003. e-Pub 2003. PMID: 15136975.
- Hughes C, Lehner F, Dirikolu L, Harkins D, Boyles J, McDowell K, Tobin T, Crutchfield J, Sebastian MM, Harrison L, Baskin SI. A simple and highly sensitive spectrophotometric method for the determination of cyanide in equine blood. Toxicology Mechanisms and Methods 13(2):129-138, 2003. e-Pub 2003. PMID: 20021191.
- Roberts JF, Vickers ML, Sells SF, Watson DL, Billings SK, Jackson CB, Palmer-Ball BL, Harrison LR, Bolin DC, Giles RC, Sebastian MM. Passive surveillance of West Nile virus from wild birds of Kentucky. The Kentucky Warbler 79(2):53-9, 2003. e-Pub 2003.
- Dirikolu L, Hughes C, Harkins D, Boyles J, Bosken J, Lehner F, Troppmann A, McDowell K, Tobin T, Sebastian MM, Harrison L, Crutchfield J, Baskin SI, Fitzgerald TD. The toxicokinetics of cyanide and mandelonitrile in the horse and their relevance to the mare reproductive loss syndrome. Toxicol Mech Methods 13(3):199-211, 2003. e-Pub 2003. PMID: 20021160.
- Sebastian MM, Anilkumar R, Mini M, Ismail PK, Rajan A. Reversal of aflatoxin induced liver damage by turmeric, curcumin and chitosan. International Journal of Animal Sciences 16:155-7, 2001. e-Pub 2001.
- Sebastian MM, Sreekumaran T, Madhusoodanan Pillai R, Ramachandran KM, Rajan A. Evaluation of antibodies as a diagnostic marker in ethmoid carcinoma. Journal of Veterinary and Animal Sciences 29:76-7, 1998. e-Pub 1998.
- Sebastian MM, Shanwaz KR, Eliyas A, Rajan A, Vasudevan DM. Demonstration of tumor associated antigen in ethmoid carcinoma. International Journal of Animal Sciences 13:117-20, 1998. e-Pub 1998.
- Sebastian MM, Remani P, Rajan A. Jackfruit lectin as a histochemical marker for ethmoid carcinoma in bovines. International Journal of Animal Sciences 13:165-8, 1998. e-Pub 1998.
- Sebastian MM, Mini M, Rajan A. Circulating immune complexes as a tumor marker in carcinoma of the ethmoid mucosa in cattle. Journal of Veterinary and Animal Sciences 26:37-9, 1995. e-Pub 1995.
- Valsala KV, Sebastian MM, Rajan A. Granulosa cell tumor in a civet cat (Viverricula indica). Indian Journal of Veterinary Pathology 19:51-2, 1995. e-Pub 1995.
Invited Articles
- Sebastian MM, Bernard WV, Riddle TW, Latimer CR, Fitzgerald TD, Harrison LR. REVIEW paper: mare reproductive loss syndrome. Vet Pathol 45(5):710-22, 2008. e-Pub 2008. PMID: 18725479.
Other Articles
- Zhao S, Habib SL, Senejani AG, Sebastian M, Kidane D Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy. Biomedicines 10(3), 2022. PMID: 35327359.
- Pantanowitz L, Bui MM, Chauhan C, ElGabry E, Hassell L, Li Z, Parwani AV, Salama ME, Sebastian M, Tulman D, Vepa S, Becich MJ Rules of engagement: Promoting academic-industry partnership in the era of digital pathology and artificial intelligence. Acad Pathol 9(1):100026, 2022. PMID: 35669406.
- El Bairi, K, Haynes, HR, Blackley, EF, Fineberg, S, Shear, J, Turner, S, de Freitas, JR, Sur, D, Amendola, LC, Gharib, M, Kallala, A, Arun, I, Azmoudeh-Ardalan, F, Fujimoto, L, Sua, LF, Liu, SW, Lien, HC, Kirtani, P, Balancin, ML, El Attar, H, Guleria, P, Yang, W, Shash, E, Chen, IC, Bautista, V, Do Prado Moura, JF, Rapoport, B, Castaneda, CA, Spengler, E, Acosta-Haab, G, Frahm, I, Sanchez, J, Castillo, M, Bouchmaa, N, Md Zin, RR, Shui, R, Onyuma, T, Yang, W, Husain, Z, Willard-Gallo, K, Coosemans, A, Perez, EA, Provenzano, E, Ericsson, PG, Toi, M, Yang, W, Symmans, WF, Sebastian, MM, Yuan, Y, Lazar, A The tale of TILs in breast cancer. npj Breast Cancer 7(1), 2021. PMID: 34853355.
- Hudeček, J, Voorwerk, L, van Seijen, M, Nederlof, I, de Maaker, M, van den Berg, J, Van De Vijver, K, Sikorska, K, Adams, S, Demaria, S, Viale, G, Nielsen, TO, Badve, S, Michiels, S, Symmans, WF, Sotiriou, C, Rimm, DL, Hewitt, SM, Denkert, C, Loibl, S, Loi, S, Bartlett, JM, Pruneri, G, Dillon, D, Cheang, M, Tutt, A, Hall, JA, Kos, Z, Salgado, R, Kok, M, Horlings, HM, Hyytiäinen, A, Hida, AI, Thompson, A, Lefevre, A, Lazar, A, Gown, AM, Lo, A, Sapino, A, Madabhushi, A, Moreira, A, Richardson, AL, Vingiani, A, Beck, AH, Bellizzi, AM, Guerrero, A, Grigoriadis, A, Sebastian, MM, Yang, W, Yuan, Y Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials. npj Breast Cancer 6(1), 2020. PMID: 32436923.
- Amgad M, Stovgaard ES, Balslev E, Thagaard J, Chen W, Dudgeon S, Sharma A, Kerner JK, Denkert C, Yuan Y, AbdulJabbar K, Wienert S, Savas P, Voorwerk L, Beck AH, Madabhushi A, Hartman J, Sebastian M, Horlings HM, Hudecek J, Ciompi F, Moore DA, Singh R, Roblin E, Balancin ML, Mathieu MC, Lennerz JK, Kirtani P, Chen IC, Braybrooke JP, Pruneri G, Demaria S, Adams S, Schnitt SJ, Lakhani SR, Rojo F, Comerma L, Badve SS, Khojasteh M, Symmans WF, Sotiriou C, Gonzalez-Ericsson P, Pogue-Geile KL, Kim RS, Rimm DL, Viale G, Hewitt SM, Bartlett JMS, Penault-Llorca F, Goel S, Lien HC, Loibl S, Kos Z, Loi S, Hanna MG, Michiels S, Kok M, Nielsen TO, Lazar AJ, Bago-Horvath Z, Kooreman LFS, Laak JAWM VD, Saltz J, Gallas BD, Kurkure U, Barnes M, Salgado R, Cooper LAD, Working Group IIB Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group. NPJ Breast Cancer 6(1):16, 2020. PMID: 32411818.
- Tan JY, Valberg SJ, Sebastian MM, Davis GD, Kelly JR, Goehring LS, Harland MM, Kuebelbeck KL, Waldridge BM, Newton JC, Reimer JM Suspected systemic calcinosis and calciphylaxis in 5 horses. Can Vet J 51(9):993-9, 2010. PMID: 21119866.
- Brendon RW, Sebastian MM Erratum. Fetal and Pediatric Pathology 29(3):183, 2010.
- Bendon RW, Brendon RW, Sebastian MM Stillborn infant with calcified chorionic epithelium, corneal scarring, and pericarditis. Fetal Pediatr Pathol 28(6):274-8, 2009. PMID: 19842882.
- Sebastian M, Bernard W, Fitzgerald T Mare Reproductive Loss Syndrome (Review Article). Compendium on Continuing Education for the Practicing Veterinarian, 2006.
Book Chapters
- Sebastian MM, Borjeson TM. Embryology and teratology, 863-890, 2019.
- Sebastian MM, Borjeson TM. In: Embryology and teratology. Elsevier, 28, 2019.
- Laflamme MA, Sebastian MM, Buetow BS. Cardiovascular, 135-153, 2012.
- Laflamme MA, Sebastian MM, Beutow BS. Chapter 10, Cardiovascular System. In: Comparative Anatomy & Histology: A Mouse and Human Atlas. Elsevier, 135-153, 2012.
- Sebastian MM. Mare reproductive loss syndrome, 1139-1144, 2011.
- Sebastian MM. Renal toxicity, 561-574, 2009.
- Sebastian M. Chapter 38, Renal Toxicity. In: Handbook of Toxicology of Chemical Warfare Agents. Academic Press, 561-574, 2009.
- Sebastian MM, Bernard WV, Harrison L. Caterpillars and mare reproductive loss syndrome, 777-784, 2007.
- Sebastian MM, Baskin SI, Czerwinski SE. Renal toxicity, 161-176, 2007.
- Sebastian MM. Role of pathology in diagnosis, 1100-1136, 2007.
- Sebastian, MM, Baskin, SI, Czerwinski, SE. Renal toxicity, 161-176, 2007.
- Baskin, SI, Czerwinski, SE, Anderson, JB, Sebastian, MM. Cardiovascular toxicity, 193-205, 2007.
- Sebastian M. Chapter 91: Role of Pathology in Diagnosis. In: Veterinary Toxicology: Basic & Clinical Principles. Academic Press, 1100-1138, 2007.
- Baskin SI, Czerwinski SE, Anderson JB, Sebastian M. Chapter 16: Cardiovascular Toxicity. In: Veterinary Toxicology: Basic & Clinical Principles. Academic Press, 193-205, 2007.
- Perkins NR, Sebastian MM, Todhunter KH, Wylie RM, Begg AP, Gilkerson JR, Racklyeft DJ, Chicken C, Wilson MC, Cawdell-Smith AJ, Bryden WL. Chapter 26: Pregnancy loss in mares associated with exposure to caterpillars in Kentucky and Australia. In: Poisonous Plants: Global Research and Solutions. CABI Publishing, 165-169, 2007.
- Sebastian M, Czerwinski SE, Baskin SI. Chapter 13: Renal Toxicity. In: Veterinary Toxicology: Basic & Clinical Principles. Academic Press, 161-176, 2007.
- Sebastian MM, Bernard W. Chapter 63: Caterpillars and mare reproductive loss syndrome. In: Veterinary Toxicology: Basic & Clinical Principles. Academic Press, 777-784, 2007.
Selected Presentations & Talks
National Presentations
- 2017. Role of Veterinarians in Translational Medicine. Conference. Role of Veterinarians in Translational Medicine. Incheon.
- 2003. Induction of Mare Reproductive Loss Syndrome with irradiated eastern tent caterpillars to assess whether the primary pathogen in MRLS is a toxic molecule or a microorganism. Conference. Induction of Mare Reproductive Loss Syndrome with irradiated eastern tent caterpillars to assess whether the primary pathogen in MRLS is a toxic molecule or a microorganism. Lexington, KY, US.
Grant & Contract Support
| Date: | 2025 - 2028 |
| Title: | Preclinical Validation of Novel Combination Therapeutic Strategies Targeting KRAS and BRAF Mutated Colorectal Cancer for Near Term Clinical Examination |
| Funding Source: | US Department of Defense |
| Role: | Collaborator |
| ID: | NA |
| Date: | 2025 - 2027 |
| Title: | Preclinical validation of vinca alkaloids in combination with AKT and PLK inhibitors for near-term clinical evaluation in KRAS and BRAF mutated colorectal cancer |
| Funding Source: | NATIONAL INSTITUTES OF HEALTH |
| Role: | Collaborator |
| Date: | 2025 - 2027 |
| Title: | Characterization of a novel Foxl2- dependent ovarian granulosa cell tumor mouse model |
| Funding Source: | NATIONAL INSTITUTES OF HEALTH |
| Role: | Collaborator |
| Date: | 2025 - 2028 |
| Title: | Novel Combination Therapeutic Strategies for KRAS and BRAF Mutated Colorectal Cancer |
| Funding Source: | CPRIT |
| Role: | Collaborator |
| Date: | 2025 - 2026 |
| Title: | Novel combination strategies targeting vulnerabilities of KRAS and BRAF mutated colorectal cancer |
| Funding Source: | HOPE FOUNDATION |
| Role: | Collaborator |
| Date: | 2024 - 2027 |
| Title: | Identification and Validation of Novel Combination Therapeutic Strategies for KRAS and BRAF Mutated Colorectal Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
| Date: | 2024 - 2025 |
| Title: | Genetically modified role of MUC13 in Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Genetically define the role of MUC13 in pancreatic carcinogenesis |
| Funding Source: | NIH |
| Role: | PI |
| Date: | 2023 - 2028 |
| Title: | Targeting PPAR-d alteration and immune suppression for gastric cancer prevention and therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Molecular Dissection of host–environment interaction in gastric tumorigenesis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | MIPS Center: Targeted Interception Program to Develop Molecular and Immunologic Prevention Strategies |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2025 |
| Title: | Development of PARG Inhibitors to Treat PARPi-resistant Breast Cancer |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| Date: | 2021 - 2026 |
| Title: | Modulation of Neuroimmune Pathways by WWOX: Implications for Complex Brain Disorders |
| Funding Source: | NIH/NIMH |
| Role: | Collaborator |
| Date: | 2021 - 2026 |
| Title: | Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA236905-01A1 |
| Date: | 2021 - 2026 |
| Title: | Investigation of toxins and phage in Acinetobacter baumannii pathogenesis |
| Funding Source: | UT-Austin/NIH |
| Role: | Co-I |
| Date: | 2021 - 2026 |
| Title: | Pharmacological Modulation of Poly(ADP-ribose) Metabolism |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01 |
| Date: | 2021 - 2026 |
| Title: | PPAR-d regulation of gastric progenitor cell sternness and tumorigenesis |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01 |
| Date: | 2020 - 2025 |
| Title: | Bis-allylic deuterated arachidonic acid (D-ARA) therapeutic for Covid-19 lung injury |
| Funding Source: | UT-Austin/NIH/NIAID |
| Role: | Co-I |
| ID: | GRANT13186003 |
| Date: | 2020 - 2021 |
| Title: | Hamamtsu NanoZoomer S60 Brightfield + Fluorescence Slide Scanning system |
| Funding Source: | NIH/NIGMS |
| Role: | PI |
| ID: | GRANT12863610 |
| Date: | 2019 - 2022 |
| Title: | NCI Preclinical PREVENT Cancer Program |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | TORFP 2019 E-05 |
| Date: | 2019 - 2023 |
| Title: | Genetic and Molecular Definition of Histone Modifying Enzyme Functions |
| Funding Source: | NIH/NIGMS |
| Role: | Co-I |
| ID: | GM131678-01 |
| Date: | 2019 - 2024 |
| Title: | DNA Polymerase Beta and Mechanisms of Carcinogenesis |
| Funding Source: | UT-Austin / NIH |
| Role: | Co-I |
| ID: | R01 Subcontract |
| Date: | 2019 - 2021 |
| Title: | Defective Base Excision Repair and Mechanisms of Infection Related Cancer |
| Funding Source: | UT-Austin / NIH |
| Role: | Co-I |
| ID: | R21 |
| Date: | 2019 - 2021 |
| Title: | Defective Base Excision Repair and Mechanisms of Infection Related Cancer |
| Funding Source: | UT-Austin / NIH |
| Role: | Co-I |
| ID: | R21 Subcontract |
| Date: | 2019 - 2020 |
| Title: | Hamamtsu NanoZoomer S60 Brightfield + Fluorescence Slide Scanning system |
| Funding Source: | NIH |
| Role: | PI |
| ID: | S10 OD027030-01 |
| Date: | 2018 - 2023 |
| Title: | The impact of nicotine product switching on use, toxicant exposure, and biomarkers of risk on smoking-related chronic medical illness |
| Funding Source: | NIH/FDA |
| Role: | Co-I |
| ID: | U54 |
| Date: | 2018 - 2023 |
| Title: | PPAR-d Regulation of Gastric Progenitor Cell Stemness and Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA222106 |
| Date: | 2018 - 2021 |
| Title: | Defining the Effects of USP22 Over Expression in Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP180083 |
| Date: | 2017 - 2019 |
| Title: | Targeted casein kinase 1δ (CK1δ) inhibition as a breast cancer prevention strategy |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | TORFP 2017-E05 |
| Date: | 2013 - 2016 |
| Title: | Development of Medical Countermeasures to Mitigate or Treat the Gastrointestinal Acute Radiation Syndrome after a Nuclear or Radiation Incident |
| Funding Source: | NIH/NIAID |
| Role: | Chief Preclinical Investigator/Pathologist |
| ID: | HHSN272201300030C |
| Date: | 2013 - 2021 |
| Title: | Cancer Center Support Grant (CCSG)-Core Grant |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | P30 CA16672 |
| Date: | 2008 - 2011 |
| Title: | Rad9-Based Mouse Model of Prostate Cancer |
| Funding Source: | NIH |
| Role: | Co-PI |
| Title: | Hybernia Safety Catheter for Neuroprotection via Selective Hypothermia |
| Funding Source: | NIH |
| Role: | Co-PI |
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CV information above last modified March 03, 2025