Marcos R. Estecio, Ph.D.

Peer-Reviewed Articles

1. Wang TC, Sawhney S, Morgan D, Bennett RL, Rashmi R, Estecio MR, Brock A, Singh I, Baer CF, Licht JD, Lele TP. Genetic variation drives cancer cell adaptation to ECM stiffness. Proc Natl Acad Sci U S A 121(39):e2403062121, 2024. e-Pub 2024. PMID: 39302966.
2. Heeke, S, Gay, CM, Estecio, MR, Tran, HT, Morris, BB, Zhang, B, Tang, X, Raso, G, Rocha, P, Lai, S, Arriola, E, Hofman, P, Hofman, V, Kopparapu, P, Lovly, CM, Concannon, K, Guimares de Sousa, L, Lewis, WE, Kondo, K, Hu, X, Tanimoto, A, Vokes, N, Nilsson, M, Stewart, C, Jansen, M, Horváth, I, Gaga, M, Panagoulias, V, Raviv, Y, Frumkin, D, Wasserstrom, A, Shuali, A, Schnabel, CA, Xi, Y, Diao, L, Wang, Q, Zhang, J, Van Loo, P, Wang, J, Wistuba, II, Byers, LA, Heymach, JV. Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes. Cancer cell 42(2):225-237.e5, 2024. e-Pub 2024. PMID: 38278149.
3. Fuentes-Mattei, E, Bayraktar, R, Manshouri, T, Silva, AM, Ivan, C, Gulei, D, Fabris, L, Soares do Amaral, N, Mur, P, Perez, C, Torres-Claudio, E, Dragomir, M, Badillo-Perez, A, Knutsen, E, Narayanan, P, Golfman, LS, Shimizu, M, Zhang, X, Zhao, W, Ho, WT, Estecio, MR, Bartholomeusz, G, Tomuleasa, C, Berindan-Neagoe, I, Zweidler-McKay, PA, Estrov, Z, Zhao, ZJ, Verstovsek, S, Calin, GA, Redis, RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight 9(3), 2024. e-Pub 2024. PMID: 38329131.
4. Simper, M, Coletta, LD, Gaddis, S, Lin, H, Mikulec, C, Takata, Y, Tomida, MW, Zhang, D, Tang, DG, Estecio, MR, Shen, J, Lu, Y. Commercial ChIP-Seq Library Preparation Kits Performed Dierently for Dierent Classes of Protein Targets. Journal of Biomolecular Techniques 33(3), 2023. e-Pub 2023. PMID: 36910579.
5. Figueroa M, Ma H, Alfayez M, Morales-Mantilla DE, Wang F, Lu Y, Estecio MR, King KY, Kleinerman ES, Moghaddam, SJ, Daver NG, Andreeff M, Konopleva MY, DiNardo CD, Chandra J. Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Adv 7(21):6624-6629, 2023. PMID: 37486624.
6. Chen, Q, Liu, B, Zeng, Y, Hwang, JW, Dai, N, Corrêa, IR, Estecio, MR, Zhang, X, Albuquerque Almeida Santos, M, Chen, T, Cheng, X. GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer 5(2), 2023. e-Pub 2023. PMID: 37206360.
7. Zhao M, DiPeri TP, Raso MG, Zheng X, Rizvi YQ, Evans KW, Yang F, Akcakanat A, Estecio MR, Tripathy D, Dumbrava EE, Damodaran S, Meric-Bernstam F. Epigenetically upregulating TROP2 and SLFN11 enhances therapeutic efficacy of TROP2 antibody drug conjugate sacitizumab govitecan. npj Breast Cancer, 2023. e-Pub 2023. PMID: 37567892.
8. Soundararajan R, Viscuse P, Pilie P, Liu J, Logotheti S, Laberiano Fernández C, Lorenzini D, Hoang A, Lu W, Soto LMS, Wistuba II, Xu M, Song X, Shepherd PDA, Navone NM, Tidwell RSS, Lozano G, Logothetis C, Zhang J, Long JP, Estecio MR, Tzelepi V, Aparicio AM. Genotype-to-Phenotype Associations in the Aggressive Variant Prostate Cancer Molecular Profile (AVPC-m) Components. Cancers (Basel) 14(14):3233, 2022. e-Pub 2022. PMID: 35805010.
9. Tu SM, Estecio MR, Lin SH, Zacharias NM. Stem Cell Theory of Cancer: Rude Awakening or Bad Dream from Cancer Dormancy?. Cancers (Basel) 14(3), 2022. e-Pub 2022. PMID: 35158923.
10. Darbaniyan F, Zheng H, Kanagal-Shamanna R, Lockyer P, Montalban-Bravo G, Estecio M, Lu Y, Soltysiak KA, Chien KS, Yang H, Sasaki K, Class C, Ganan-Gomez I, Do KA, Garcia-Manero G, Wei Y. Transcriptomic Signatures of Hypomethylating Agent Failure in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Exp Hematol 115:44-53, 2022. e-Pub 2022. PMID: 36150563.
11. Morales F, Corrales E, Zhang B, Vásquez M, Santamaría-Ulloa C, Quesada H, Sirito M, Estecio MR, Monckton DG, Krahe R. Myotonic dystrophy type 1 (DM1) clinical sub-types and CTCF site methylation status flanking the CTG expansion are mutant allele length-dependent. Hum Mol Genet 31(2):262-274, 2021. e-Pub 2021. PMID: 34432028.
12. Johnson KC, Anderson KJ, Courtois ET, Gujar AD, Barthel FP, Varn FS, Luo D, Seignon M, Yi E, Kim H, Estecio MRH, Zhao D, Tang M, Navin NE, Maurya R, Ngan CY, Verburg N, de Witt Hamer PC, Bulsara K, Samuels ML, Das S, Robson P, Verhaak RGW. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response. Nat Genet 53(10):1456-1468, 2021. e-Pub 2021. PMID: 34594038.
13. Dejima H, Hu X, Chen R, Zhang J, Fujimoto J, Parra ER, Haymaker C, Hubert SM, Duose D, Solis LM, Su D, Fukuoka J, Tabata K, Pham HHN, Mcgranahan N, Zhang B, Ye J, Ying L, Little L, Gumbs C, Chow CW, Estecio MR, Godoy MCB, Antonoff MB, Sepesi B, Pass HI, Behrens C, Zhang J, Vaporciyan AA, Heymach JV, Scheet P, Lee JJ, Wu J, Futreal PA, Reuben A, Kadara H, Wistuba II, Zhang J. Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features. Nat Commun 12(1):2722, 2021. e-Pub 2021. PMID: 33976164.
14. DiNardo CD, Beird HC, Estecio M, Hardikar S, Takahashi K, Bannon SA, Borthakur G, Jabbour E, Gumbs C, Khoury JD, Routbort M, Gong T, Kondo K, Kantarjian H, Garcia-Manero G, Chen T, Futreal PA. Germline DNMT3A mutation in familial acute myeloid leukaemia. Epigenetics 16(5):1-10, 2021. e-Pub 2021. PMID: 32856987.
15. Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J. Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas. Nat Commun 12(1):687, 2021. e-Pub 2021. PMID: 33514726.
16. Cortez MA, Masrorpour F, Ivan C, Zhang J, Younes AI, Lu Y, Estecio MR, Barsoumian HB, Menon H, Caetano MDS, Ramapriyan R, Schoenhals JE, Wang X, Skoulidis F, Wasley MD, Calin G, Hwu P, Welsh JW. Bone morphogenetic protein 7 promotes resistance to immunotherapy. Nat Commun 11(1):4840, 2020. e-Pub 2020. PMID: 32973129.
17. Morales F, Vásquez M, Corrales E, Vindas-Smith R, Santamaría-Ulloa C, Zhang B, Sirito M, Estecio MR, Krahe R, Monckton DG. Longitudinal increases in somatic mosaicism of the expanded CTG repeat in myotonic dystrophy type 1 are associated with variation in age-at-onset. Hum Mol Genet 29(15):2496-2507, 2020. e-Pub 2020. PMID: 32601694.
18. Herrera-Merchan A, Cuadros M, Rodriguez MI, Rodriguez S, Torres R, Estecio M, Coira IF, Loidi C, Saiz M, Carmona-Saez P, Medina PP. The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma. Oncotarget 11(13):1172-1185, 2020. e-Pub 2020. PMID: 32284793.
19. Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight 5(1), 2020. e-Pub 2020. PMID: 31941838.
20. Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N. DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis 40(11):1332-1340, 2019. e-Pub 2019. PMID: 31284295.
21. Veland N, Lu Y, Hardikar S, Gaddis S, Zeng Y, Liu B, Estecio MR, Takata Y, Lin K, Tomida MW, Shen J, Saha D, Gowher H, Zhao H, Chen T. DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells. Nucleic Acids Res 47(1):152-167, 2019. e-Pub 2019. PMID: 30321403.
22. Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA. DNMT3A and TET1 Cooperate to Regulate Promoter Epigenetic Landscapes in Mouse Embryonic Stem Cells. Genome Biol 19(1):88, 2018. e-Pub 2018. PMID: 30001199.
23. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res 28(4):432-447, 2018. e-Pub 2018. PMID: 29567676.
24. Rossi EL, Dunlap SM, Bowers LW, Khatib SA, Doerstling SS, Smith LA, Ford NA, Holley D, Brown PH, Estecio MR, Kusewitt DF, deGraffenried LA, Bultman SJ, Hursting SD. Energy balance modulation impacts epigenetic reprogramming, ERα and ERβ expression and mammary tumor development in MMTV-neu transgenic mice. Cancer Res 77(9):2500-2511, 2017. e-Pub 2017. PMID: 28373182.
25. Quek K, Li J, Estecio M, Zhang J, Fujimoto J, Roarty E, Little L, Chow CW, Song X, Behrens C, Chen T, William WN, Swisher S, Heymach J, Wistuba I, Zhang J, Futreal A, Zhang J. DNA methylation intratumor heterogeneity in localized lung adenocarcinomas. Oncotarget 8(13):21994-22002, 2017. e-Pub 2017. PMID: 28423542.
26. Long Y, Tsai WB, Chang JT, Estecio M, Wangpaichitr M, Savaraj N, Feun LG, Chen HH, Kuo MT. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget 7(50):82658-82670, 2016. e-Pub 2016. PMID: 27765932.
27. Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep 16(1):133-47, 2016. e-Pub 2016. PMID: 27320920.
28. Rossi EL, de Angel RE, Bowers LW, Khatib SA, Smith LA, Van Buren E, Bhardwaj P, Giri D, Estecio MR, Troester MA, Hair BY, Kirk EL, Gong T, Shen J, Dannenberg AJ, Hursting SD. Obesity-Associated Alterations in Inflammation, Epigenetics, and Mammary Tumor Growth Persist in Formerly Obese Mice. Cancer Prev Res (Phila) 9(5):339-48, 2016. e-Pub 2016. PMID: 26869351.
29. Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A. Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas. Epigenetics 11(3):184-93, 2016. e-Pub 2016. PMID: 26890396.
30. Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estécio MR, Sahin AA, Aldaz CM. A Molecular Portrait Of High-Grade Ductal Carcinoma In Situ (DCIS). Cancer Res 75(18):3980-90, 2015. e-Pub 2015. PMID: 26249178.
31. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estécio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol 36(10):8147-58, 2015. e-Pub 2015. PMID: 25990457.
32. Rolyan H, Tyurina YY, Hernandez M, Amoscato AA, Sparvero LJ, Nmezi BC, Lu Y, Estécio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH, Dupree J, Bayir H, Kagan VE, Casaccia P, Padiath QS. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci 35(34):12002-17, 2015. e-Pub 2015. PMID: 26311780.
33. Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estécio MR, Godley LA, Issa JP. TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res 75(14):2833-43, 2015. e-Pub 2015. PMID: 25972343.
34. Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estécio MR, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell 27(5):644-57, 2015. e-Pub 2015. PMID: 25965571.
35. Estécio MR, Maddipoti S, Bueso-Ramos C, DiNardo CD, Yang H, Wei Y, Kondo K, Fang Z, Stevenson W, Chang KS, Pierce SA, Bohannan Z, Borthakur G, Kantarjian H, Garcia-Manero G. RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype. Br J Haematol 169(3):344-51, 2015. e-Pub 2015. PMID: 25612675.
36. Qin T, Si J, Raynal NJ, Wang X, Gharibyan V, Ahmed S, Hu X, Jin C, Lu Y, Shu J, Estécio MR, Jelinek J, Issa JP. Epigenetic synergy between decitabine and platinum derivatives. Clin Epigenetics 7(1):97, 2015. e-Pub 2015. PMID: 26366234.
37. Yang H, Maddipoti S, Quesada A, Bohannan Z, Cabrero Calvo M, Colla S, Wei Y, Estécio MR, Wierda W, Bueso-Ramos C, Garcia-Manero G. Analysis of class I and II histone deacetylase gene expression in human leukemia. Leuk Lymphoma:1-8, 2015. e-Pub 2015. PMID: 25944469.
38. Xu Y, Zheng X, Yuan Y, Estécio MR, Issa JP, Qiu P, Ji Y, Liang S. BM-SNP: A Bayesian Model for SNP Calling Using High Throughput Sequencing Data. IEEE/ACM Trans Comput Biol Bioinform 11(6):1038-44, 2014. e-Pub 2014. PMID: 26357041.
39. Yang H, Bueso-Ramos C, DiNardo C, Estecio MR, Davanlou M, Geng QR, Fang Z, Nguyen M, Pierce S, Wei Y, Parmar S, Cortes J, Kantarjian H, Garcia-Manero G. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents. Leukemia 28(6):1280-8, 2014. e-Pub 2014. PMID: 24270737.
40. Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP. Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res 24(4):580-91, 2014. e-Pub 2014. PMID: 24414704.
41. Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, Shureiqi I, Toyota M, Kondo Y, Estecio MR, Issa JP. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res 74(5):1311-8, 2014. e-Pub 2014. PMID: 24385213.
42. Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estécio MR. Colorectal Carcinomas with CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators. Gastroenterology 146(2):530-38.e5, 2014. e-Pub 2014. PMID: 24211491.
43. Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res, 2014. e-Pub 2014. PMID: 24875481.
44. Tahara T, Maegawa S, Chung W, Garriga J, Jelinek J, Estecio MR, Shibata T, Hirata I, Arisawa T, Issa JP. Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. Cancer Prev Res (Phila) 6(10):1093-100, 2013. e-Pub 2013. PMID: 23943784.
45. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 23(9):1446-61, 2013. e-Pub 2013. PMID: 23796952.
46. Yamazaki J, Estécio MR, Lu Y, Long H, Malouf GG, Graber D, Huo Y, Ramagli L, Liang S, Kornblau SM, Jelinek J, Issa JP. The epigenome of AML stem and progenitor cells. Epigenetics 8(1):92-104, 2013. e-Pub 2013. PMID: 23249680.
47. Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estécio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol 14(12):R144, 2013. e-Pub 2013. PMID: 24367927.
48. Jelinek J, Liang S, Lu Y, He R, Ramagli LS, Shpall EJ, Estécio MR, Issa JP. Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics 7(12):1368-78, 2012. e-Pub 2012. PMID: 23075513.
49. Xu Y, Zheng X, Yuan Y, Estécio MR, Issa JP, Ji Y, Liang S. A Bayesian Model for SNP Discovery Based on Next-Generation Sequencing Data. IEEE Int Workshop Genomic Signal Process Stat 2012:42-45, 2012. e-Pub 2012. PMID: 26726304.
50. Estécio MR, Gallegos J, Dekmezian M, Lu Y, Liang S, Issa JP. SINE Retrotransposons Cause Epigenetic Reprogramming of Adjacent Gene Promoters. Mol Cancer Res 10(10):1332-42, 2012. e-Pub 2012. PMID: 22952045.
51. Zhang Y, Shu J, Si J, Shen L, Estécio MR, Issa JP. Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island. Nucleic Acids Res 40(15):7257-68, 2012. e-Pub 2012. PMID: 22600741.
52. Raynal NJ, Si J, Taby RF, Gharibyan V, Ahmed S, Jelinek J, Estécio MR, Issa JP. DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res 72(5):1170-81, 2012. e-Pub 2012. PMID: 22219169.
53. Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estécio MR, Jelinek J, Godley LA, Issa JP. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics 7(2):201-7, 2012. e-Pub 2012. PMID: 22395470.
54. Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estécio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One 6(11):e27889, 2011. e-Pub 2011. PMID: 22132162.
55. Jelinek J, Gharibyan V, Estécio MR, Kondo K, He R, Chung W, Lu Y, Zhang N, Liang S, Kantarjian HM, Cortes JE, Issa JP. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. PLoS One 6(7):e22110, 2011. e-Pub 2011. PMID: 21760961.
56. Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estécio MR, Shen L, Jelinek J, Issa JP. Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer. PLoS One 6(8):e23320, 2011. e-Pub 2011. PMID: 21853109.
57. Estécio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP. Genome Architecture Marked by Retrotransposons Modulates Predisposition to DNA Methylation in Cancer. Genome Res 20(10):1369-1382, 2010. e-Pub 2010. PMID: 20716667.
58. Tellez CS, Shen L, Estécio MR, Jelinek J, Gershenwald JE, Issa JP. CpG island methylation profiling in human melanoma cell lines. Melanoma Res 19(3):146-55, 2009. e-Pub 2009. PMID: 19441164.
59. Watanabe Y, Kim HS, Castoro RJ, Chung W, Estécio MR, Kondo K, Guo Y, Ahmed SS, Toyota M, Itoh F, Suk KT, Cho MY, Shen L, Jelinek J, Issa JP. Sensitive and Specific Detection of Early Gastric Cancer Using DNA Methylation Analysis of Gastric Washes. Gastroenterology 136(7):2149-58, 2009. e-Pub 2009. PMID: 19375421.
60. Liang S, Lu Y, Jelinek J, Estécio MR, Li H, Issa JP. Analysis of epigenetic modifications by next generation sequencing. Conf Proc IEEE Eng Med Biol Soc 1:6730, 2009. e-Pub 2009. PMID: 19963934.
61. Kroeger H, Jelinek J, Estécio MR, He R, Kondo K, Chung W, Zhang L, Shen L, Kantarjian HM, Bueso-Ramos CE, Issa JP. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 112(4):1366-73, 2008. e-Pub 2008. PMID: 18523155.
62. Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Estécio MR, Ahmed S, Issa JP. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet 4(8):e1000162, 2008. e-Pub 2008. PMID: 18725933.
63. Estecio MR, Yan PS, Ibrahim AE, Tellez CS, Shen L, Huang TH, Issa JP. High throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res 17(10):1529-1536, 2007. e-Pub 2007. PMID: 17785535.
64. Choi IS, Estecio MR, Nagano Y, Kim do H, White JA, Yao JC, Issa JP, Rashid A. Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol 20(7):802-10, 2007. e-Pub 2007. PMID: 17483816.
65. Estecio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE 2(5):399, 2007. e-Pub 2007. PMID: 17476321.
66. Montero AJ, Díaz-Montero CM, Mao L, Youssef EM, Estécio MR, Shen L, Issa JP. Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer. Cancer Biol Ther 5(11):1494-501, 2006. e-Pub 2006. PMID: 17369752.
67. Estecio MR, Youssef EM, Rahal P, Fukuyama EE, Gois-Filho JF, Maniglia JV, Goloni-Bertollo EM, Issa JP, Tajara EH. LHX6 is a sensitive methylation marker in head and neck carcinomas. Oncogene 25(36):5018-26, 2006. e-Pub 2006. PMID: 16732332.
68. Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res 66(10):5495-503, 2006. e-Pub 2006. PMID: 16707479.
69. Reis EM, Ojopi EP, Alberto FL, Rahal P, Tsukumo F, Mancini UM, Guimarães GS, Thompson GM, Camacho C, Miracca E, Carvalho AL, Machado AA, Paquola AC, Cerutti JM, da Silva AM, Pereira GG, Valentini SR, Nagai MA, Kowalski LP, Verjovski-Almeida S, Tajara EH, Dias-Neto E, Bengtson MH, Canevari RA, Carazzolle MF, Colin C, Costa FF, Costa MC, Estécio MR, Esteves LI, Federico MH, Guimarães PE, Hackel C, Kimura ET, Leoni SG, Maciel RM, Maistro S, Mangone FR, Massirer KB, Matsuo SE, Nobrega FG, Nóbrega MP, Nunes DN, Nunes F, Pandolfi JR, Pardini MI, Pasini FS, Peres T, Rainho CA, dos Reis PP, Rodrigus-Lisoni FC, Rogatto SR, dos Santos A, dos Santos PC, Sogayar MC, Zanelli CF, Zanelli CF. Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer. Cancer Res 65(5):1693-9, 2005. e-Pub 2005. PMID: 15753364.
70. Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 32(3):38, 2004. e-Pub 2004. PMID: 14973332.
71. Youssef EM, Estecio MR, Issa JP. Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer. Cancer Biol Ther 3(1):82-6, 2004. e-Pub 2004. PMID: 14726683.
72. Yang AS, Estecio MR, Garcia-Manero G, Kantarjian HM, Issa JP. Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation". Science 302(5648):1153, 2003. e-Pub 2003. PMID: 14615517.
73. Brentani H, Caballero OL, Camargo AA, da Silva AM, da Silva WA, Dias Neto E, Grivet M, Gruber A, Guimaraes PE, Hide W, Iseli C, Jongeneel CV, Kelso J, Nagai MA, Ojopi EP, Osorio EC, Reis EM, Riggins GJ, Simpson AJ, de Souza S, Stevenson BJ, Strausberg RL, Tajara EH, Verjovski-Almeida S, Acencio ML, Bengtson MH, Bettoni F, Bodmer WF, Briones MR, Camargo LP, Cavenee W, Cerutti JM, Coelho Andrade LE, Costa dos Santos PC, Ramos Costa MC, da Silva IT, Estecio MR, Sa Ferreira K, Furnari FB, Faria M, Galante PA, Guimaraes GS, Holanda AJ, Kimura ET, Leerkes MR, Lu X, Maciel RM, Martins EA, Massirer KB, Melo AS, Mestriner CA, Miracca EC, Miranda LL, Nobrega FG, Oliveira PS, Paquola AC, Pandolfi JR, Campos Pardini MI, Passetti F, Quackenbush J, Schnabel B, Sogayar MC, Souza JE, Valentini SR, Zaiats AC, Amaral EJ, Arnaldi LA, de Araújo AG, de Bessa SA, Bicknell DC, Ribeiro de Camaro ME, Carraro DM, Carrer H, Carvalho AF, Colin C, Costa F, Curcio C, Guerreiro da Silva ID, Pereira da Silva N, Dellamano M, El-Dorry H, Espreafico EM, Scattone Ferreira AJ, Ayres Ferreira C, Fortes MA, Gama AH, Giannella-Neto D, Giannella ML, Giorgi RR, Goldman GH, Goldman MH, Hackel C, Ho PL, Kimura EM, Kowalski LP, Krieger JE, Leite LC, Lopes A, Luna AM, Mackay A, Mari SK, Marques AA, Martins WK, Montagnini A, Mourão Neto M, Nascimento AL, Neville AM, Nobrega MP, O'Hare MJ, Otsuka AY, Ruas de Melo AI, Paco-Larson ML, Guimarães Pereira G, Pereira da Silva N, Pesquero JB, Pessoa JG, Rahal P, Rainho CA, Rodrigues V, Rogatto SR, Romano CM, Romeiro JG, Rossi BM, Rusticci M, Guerra de Sá R, Sant' Anna SC, Sarmazo ML, Silva TC, Soares FA, Sonati Mde F, de Freitas Sousa J, Queiroz D, Valente V, Vettore AL, Villanova FE, Zago MA, Zalcberg H, Zalcberg H, Zalcberg H. The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A 23(23):13418-23, 2003. e-Pub 2003. PMID: 14593198.
74. Estecio MR, Silva AE. [Chromosome abnormalities caused by computer video display monitors' radiation]. Rev Saude Publica 36(3):330-6, 2002. e-Pub 2002. PMID: 12131973.
75. Estecio MR, Fett-Conte AC, Varella-Garcia M, Fridman C, Silva AE. Molecular and cytogenetic analyses on Brazilian youths with pervasive developmental disorders. J Autism Dev Disord 32(1):35-41, 2002. e-Pub 2002. PMID: 11916331.
76. Estecio, MR, Fett-Conte, AC, Silva, AE. Relevância da genética na etiologia do autismo. Jornal Brasileiro de Psiquiatria 49(7):239-246, 2000. e-Pub 2000.

Invited Articles

1. Gladych M, Andrzejewska A, Oleksiewicz U, Estécio MR. Epigenetic mechanisms of induced pluripotency. Contemp Oncol (Pozn) 19(1A):A30-8, 2015. e-Pub 2015. PMID: 25691819.
2. Estécio MR, Issa JP. Dissecting DNA hypermethylation in cancer. FEBS Lett 585(13):2078-86, 2011. e-Pub 2011. PMID: 21146531.
3. Estécio MR, Issa JP. Tackling the methylome: recent methodological advances in genome-wide methylation profiling. Genome Med 1(11):106, 2009. e-Pub 2009. PMID: 19930617.
4. Estécio MR, Yan PS, Huang TH, Issa JP. Methylated CpG island amplification and microarray (MCAM) for high-throughput analysis of DNA methylation. CSH Protoc 3(3):pdb.prot4974, 2008. e-Pub 2008. PMID: 21356790.
5. Carareto CM, Estecio MR, Tajara EH. Transposable elements and human disease: from genomic instability to carcinogenesis. HB Cientifica 8:113-125, 2001. e-Pub 2001.
6. Estecio MR, Fett-Conte AC, Silva AE. Relevance of genetics in autism etiology. Jornal Brasileiro de Psiquiatria 49:239-246, 2000. e-Pub 2000.

Other Articles

1. Cortez, MA, Masrorpour, F, Ivan, C, Zhang, J, Younes, AI, Lu, Y, Estecio, MR, Barsoumian, H, Menon, H, da Silva Caetano, M, Ramapriyan, R, Schoenhals, JE, Wang, X, Skoulidis, F, Wasley, M, Calin, GA, Hwu, P, Welsh, J Author Correction. Nature communications 11(1), 2020. PMID: 33033261.

Letters to the Editor

1. Mancini UM, Estécio MR, Góis JF, Fukuyama EE, Valentim PJ, Cury PM, Bertollo EM, Tajara EH. The chromosome 5q21 band minisatellite and head and neck cancer. Cancer Genet Cytogenet 147: 87-8, 2003.