Marcos R. Estecio, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
The main focus of my research is to understand the origin and significance of abnormal epigenetic marking in cancer, with a special interest in DNA methylation. My hypothesis is that genetic lesions are the underlying cause of the observed increase in DNA methylation in several tumors types. My working model is that the molecular signals dictated by these lesions do not affect the genome in a homogeneous fashion; a predisposing state must exist and in such rests the tissue specificity of genetic lesions and targeted DNA methylated genes. I am currently developing two main research projects based on the hypothesis stated above. In the first project, using colorectal tumors as a model, I am investigating the presence of genetic lesions that are correlated with a form of epigenetic instability termed CIMP (CpG Island Methylator Phenotype). In a second project, I am taking a comprehensive approach to link gene regulatory signals (including chromatin organization) to aberrant DNA methylation. I anticipate that my research will have broad impact in the understanding of gene regulation, the origin of altered epigenetic marking and the influence of these alterations on cancer.
Education & Training
Degree-Granting Education
| 2003 | Sao Paulo State University, Sao Jose do Rio Preto, BR, Ph.D. in Genetics |
| 1999 | Sao Paulo State University, Sao Jose do Rio Preto, BR, M.S. in Biology |
| 1996 | Sao Paulo State University, Sao Jose do Rio Preto, BR, B.S. in Biology |
Postgraduate Training
| 2003-2007 | Research Fellowship, Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Associate Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2017 - 2023
Assistant Professor, Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2012 - 2017
Assistant Professor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2011 - 2012
Assistant Professor, Leukemia - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2011 - 2011
Instructor, Leukemia - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2007 - 2011
Administrative Appointments/Responsibilities
Co-Director, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2018 - Present
Director, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2012 - 2018
Intramural Institutional Committee Activities
Committee Member, FS Research Integrity Officer Task Force, UT M.D. Anderson Cancer Center, 2024 - Present
Committee Chair, AAV ABSL Subcommittee, UT M.D. Anderson Cancer Center, 2024 - 2024
Committee Member, FS Travel Affairs Subcommittee, UT M.D. Anderson Cancer Center, 2023 - Present
Extramural Institutional Committee Activities
Senator, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2023 - Present
Committee Member, Institutional Research Grant Review Panel, The University of Texas MD Anderson Cancer Center, 2023 - Present
Subcommittee Chair, IBC-Recombinant Materials, The University of Texas MD Anderson Cancer Center, 2022 - Present
Honors & Awards
| 2006 | Keystone Symposia Scholarship, Keystone Symposia and National Institute of Health |
| 2005 | AACR Minority Scholar Awards in Cancer Research, American Association for Cancer Research and National Institute of Health USA |
| 2001 | ASTRA/ZENECA Scholar-in-Training Travel Award, ASTRA/ZENECA and American Association of Cancer Research |
| 1997 | Health Care Professionals Award, Sao Jose do Rio Preto Medical School |
| 1994 - 1996 | Dean's List, Sao Paulo State University |
Professional Memberships
Grant & Contract Support
| Date: | 2027 - 2032 |
| Title: | Elucidating the role of the nuclear lamina in Alzheimer’s Disease |
| Funding Source: | University of Pittsburgh/NIH |
| Role: | Co-I |
| ID: | FP00027980_Res1 |
| Date: | 2026 - 2031 |
| Title: | Epithelial mechanisms of inducible antiviral resistance against AML-associated pneumonia |
| Funding Source: | NATIONAL HEART, LUNG, AND BLOOD INST |
| Role: | Co-I |
| ID: | R01HL187192 |
| Date: | 2026 - 2031 |
| Title: | Integrating blood-based biomarkers and machine learning predictive models for early detection of cancer therapy-induced major adverse cardiac events (MACE) |
| Funding Source: | NATIONAL INSTITUTES OF HEALTH |
| Role: | Co-I |
| ID: | R01HL187598 |
| Date: | 2025 - 2027 |
| Title: | Unraveling the Interplay: Microbiome, p16 Expression, High-Risk HPV Infection, and Clinical Outcomes in Penile Cancer Across Diverse Patient Cohorts with Varied Mortality and Incidence Profiles |
| Funding Source: | NIH |
| Role: | Co-I |
| Date: | 2025 - 2030 |
| Title: | Cancer Center Support (CORE) Grant |
| Funding Source: | NATIONAL CANCER INSTITUTE |
| Role: | Co-I |
| ID: | 5P30CA016672 |
| Date: | 2025 - 2028 |
| Title: | Mitigating strategies for risk of myeloid leukemia and poor treatment outcomes in smokers and vapers |
| Funding Source: | DoD |
| Role: | Co-I |
| Date: | 2025 - 2028 |
| Title: | Optimizing TROP2-targeted antibody-drug conjugate therapy in metastatic breast cancer |
| Funding Source: | METAVivor Research and Support, Inc |
| Role: | Co-I |
| Date: | 2025 - 2028 |
| Title: | Elucidating the role of the nuclear lamina in Alzheimer’s Disease |
| Funding Source: | NIH |
| Role: | Co-I |
| Date: | 2025 - 2020 |
| Title: | Determining Clinical Relevant Organ Specific Relative Biological Effectiveness (RBE) of Protons in Lung Cancer |
| Funding Source: | NIH |
| Role: | Co-I |
| Date: | 2025 - 2030 |
| Title: | Determining the Applicability of Penile Squamous Cell Carcinoma Patient-Derived Xenograft (PDX) Models to Recapitulate the Clinical Disease |
| Funding Source: | NIH |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Determining organ-specific relative biological effectiveness (RBE) of proton radiation using clinical data from prospective trials |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01 CA295526 |
| Date: | 2024 - 2029 |
| Title: | Elucidating the role of the nuclear lamina in Alzheimer’s Disease |
| Funding Source: | University of Pittsburgh/NIH |
| Role: | Co-I |
| Date: | 2024 - 2026 |
| Title: | Establishing an Integrated Multiomic Hub for Advancing Acute |
| Funding Source: | DoD |
| Role: | Co-I |
| Date: | 2024 - 2026 |
| Title: | NLRC5 mediated anti-tumor immunity |
| Funding Source: | M.D. Anderson Institutional Research Grant |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Precision Epigenomic Nanoengineered System (PENS) to Circumvent T-cell Exhaustion in High-grade Ovarian Cancer |
| Funding Source: | NIH |
| Role: | Co-I |
| Date: | 2024 - 2026 |
| Title: | NLRC5 Mediated Anti-Tumor Immunity in Response to Immunotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2027 |
| Title: | Understanding and mitigating effects of combustible and non-combustible tobacco use in high risk AML patients |
| Funding Source: | CPRIT |
| Role: | Co-I |
| Date: | 2024 - 2027 |
| Title: | Targeted epigenetic therapy to overcome T-Cell exhaustion in ovarian cancer |
| Funding Source: | CPRIT |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Overcoming T-cell exhaustion by demethylation of TIM3 3’UTR |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| ID: | GRANT13693524 |
| Date: | 2023 - 2025 |
| Title: | CHD enzymes in normal cellular processes |
| Funding Source: | Cockrell Endowment Fund |
| Role: | PI |
| Date: | 2022 - 2027 |
| Title: | Nanoengineered genome editing for cancer therapy |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| Date: | 2022 - 2023 |
| Title: | Novel Methylation Based Liquid Biopsies for Gliomas |
| Funding Source: | UTMDACC Brain SPORE Developmental |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Elucidating how cigarette smoking promotes AML progression and treatment resistance |
| Funding Source: | NIH/NIEHS |
| Role: | CO-I |
| Date: | 2022 - 2027 |
| Title: | Functional Analysis of Chromatin Remodeler CHD8 in Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2022 - 2024 |
| Title: | Investigation of CHD8 function in the context of BRAF status in colon cancer |
| Funding Source: | M.D. Anderson Institutional Research Grant |
| Role: | PI |
| Date: | 2021 - 2023 |
| Title: | Investigating the molecular functions of CHD8 in Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| ID: | 1-R03-CA262641-01 |
| Date: | 2020 - 2022 |
| Title: | Exploring genetic and metabolic vulnerabilities of colon cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R21 CA245349-01A1 |
| Date: | 2020 - 2022 |
| Title: | Investigating the molecular functions of CHD8 in colon cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R03 CA249242-01 |
| Date: | 2019 - 2021 |
| Title: | Exploring genetic and metabolic vulnerabilities of colon cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R21CA245349 |
| Date: | 2018 - 2023 |
| Title: | Comparative study on the effects of e-cigarette vapor versus cigarette smoke on COPD development and lung cancer promotion |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2018 - 2022 |
| Title: | Pathogenic Heterogeneity in Mucosal Stem Cells in Pediatric Crohn’s Disease |
| Funding Source: | NIH/NIDDK |
| Role: | CO-I |
| ID: | 1 R01 DK115445-01A1 |
| Date: | 2018 - 2019 |
| Title: | Evaluation and optimization of methods to measure 5--hydroxymethylcytosine (5hMC) |
| Funding Source: | MDACC |
| Role: | Project Leader |
| Date: | 2018 - 2013 |
| Title: | The impact of nicotine product switching on use, toxicant exposure, and biomarkers of risk on smoking-related chronic medical illness |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | U54HL143031 |
| Date: | 2018 - 2013 |
| Title: | Delineating the Role of the Histone Demethylase Nucleolar Protein 66 in Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| Date: | 2017 - 2020 |
| Title: | Epigenetic regulation by CHD7 in colon cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R21CA215108-01 |
| Date: | 2016 - 2021 |
| Title: | Elucidating Mechanisms Involved in Lamin B1-Mediated Demyelination |
| Funding Source: | NIH/NINDS |
| Role: | Subcontract Co-Investigator |
| ID: | 1R01NS095884-01 |
| Date: | 2013 - 2015 |
| Title: | Studying the role of the nuclear lamina in age dependent demyelination |
| Funding Source: | NIH/NIA |
| Role: | CO-I |
| ID: | 1R21AG04689701 |
| Date: | 2013 - 2015 |
| Title: | Functional study of the chromodomain protein CHD7 in colorectal cancer |
| Funding Source: | M.D. Anderson Institutional Research Grant |
| Role: | PI |
| Date: | 2011 - 2013 |
| Title: | High resolution quantitative mapping of DNA methylation in cancer |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| ID: | 1R21 CA151174-01A1 |
| Date: | 2011 - 2013 |
| Title: | Validation of the Methylation Ratio Assessment (MRA) Assay as a Cancer Diagnostic |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| ID: | PA-10-05 |
| Date: | 2011 - 2014 |
| Title: | The role of the nuclear lamina in chromatin organization and gene expression in normal and tumor cells |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R21CA153114-01A1 |
| Date: | 2011 - 2014 |
| Title: | Research Scholar Grant: "A deterministic model to explain DNA hypermethylation in cancer" |
| Funding Source: | American Cancer Society (ACS) |
| Role: | PI |
| ID: | ACS |
| Date: | 2010 - 2012 |
| Title: | Mapping of Genome-Nuclear Lamina Interactions in Embryonic Stem, iPS and Adult Cells |
| Funding Source: | NIH/NCI |
| Role: | Investigator |
| ID: | 5 P01 GM081627-04 |
| Date: | 2010 - 2012 |
| Title: | Genome-wide Transcriptome Sequencing to Identify Genetic Events Associated with or Causatively Related to CpG Island Methylator Phenotype in Colorectal Tumors |
| Funding Source: | UTMDACC – G.S. Hogan Gastrointestinal Research Fund |
| Role: | PI |
| ID: | 8-0094685 |
| Date: | 2010 - 2011 |
| Title: | Identification and characterization of local DNA features that influence gene promoter hypermethylation in cancer |
| Funding Source: | Leukemia SPORE Career Development Award |
| Role: | Investigator |
| ID: | P50 CA100632 |
| Date: | 2008 - 2009 |
| Title: | Discovery of New DNA Methylation Markers for Prognosis and Response to Treatment in Acute Myeloid Leukemia |
| Funding Source: | Leukemia Research Foundation |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Liu, B, Nayvelt, K, Hardikar, S, Kondo, K, Estecio, MR, Cheng, X, Chen, T. Functional characterization of UHRF1 variants in facilitating DNA methylation. Journal of Biological Chemistry 302(7), 2026. e-Pub 2026. PMID: 42140430.
- Bayraktar E, Rodriguez-Aguayo C, Stur E, Kumar S, Mangala LS, Jennings NB, Bayram NN, Corvigno S, Asare A, Ivan C, Kim MS, Vu TC, Hanjra P, Kim S, Ahumada AL, Wu W, Lee S, Szymanowska A, Oztatlici H, Estecio MR, Lee JS, Jain AK, Sahni N, Hagan JP, Baylin S, Liu J, Lopez-Berestein G, Pradeep S, Sood AK. Epigenetic modulation of BARD1 to enhance anti-VEGF therapy. Cell Rep Med 6(9), 2025. e-Pub 2025. PMID: 40907495.
- Chen, Q, Hardikar, S, Kondo, K, Dai, N, Corrêa, IR, Yu, M, Estecio, MR, Zhang, X, Chen, T, Cheng, X. GSK-3484862, a DNMT1 degrader, promotes DNMT3B expression in lung cancer cells. NAR Cancer 7(2), 2025. e-Pub 2025. PMID: 40433167.
- Jackson, J, Sanchez, D, Joon, A, Estecio, MR, Johns, AC, Shah, AY, Campbell, M, Ward, JF, Pisters, LL, Guo, CC, Zhang, M, Millward, NZ, Tu, S. Bilateral Germ Cell Tumor of the Testis. Cells 14(9), 2025. e-Pub 2025. PMID: 40358182.
- Wang TC, Sawhney S, Morgan D, Bennett RL, Rashmi R, Estecio MR, Brock A, Singh I, Baer CF, Licht JD, Lele TP. Genetic variation drives cancer cell adaptation to ECM stiffness. Proc Natl Acad Sci U S A 121(39):e2403062121, 2024. e-Pub 2024. PMID: 39302966.
- Heeke, S, Gay, CM, Estecio, MR, Tran, HT, Morris, BB, Zhang, B, Tang, X, Raso, G, Rocha, P, Lai, S, Arriola, E, Hofman, P, Hofman, V, Kopparapu, P, Lovly, CM, Concannon, K, Guimares de Sousa, L, Lewis, WE, Kondo, K, Hu, X, Tanimoto, A, Vokes, N, Nilsson, M, Stewart, C, Jansen, M, Horváth, I, Gaga, M, Panagoulias, V, Raviv, Y, Frumkin, D, Wasserstrom, A, Shuali, A, Schnabel, CA, Xi, Y, Diao, L, Wang, Q, Zhang, J, Van Loo, P, Wang, J, Wistuba, II, Byers, LA, Heymach, JV. Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes. Cancer cell 42(2):225-237.e5, 2024. e-Pub 2024. PMID: 38278149.
- Fuentes-Mattei, E, Bayraktar, R, Manshouri, T, Silva, AM, Ivan, C, Gulei, D, Fabris, L, Soares do Amaral, N, Mur, P, Perez, C, Torres-Claudio, E, Dragomir, M, Badillo-Perez, A, Knutsen, E, Narayanan, P, Golfman, LS, Shimizu, M, Zhang, X, Zhao, W, Ho, WT, Estecio, MR, Bartholomeusz, G, Tomuleasa, C, Berindan-Neagoe, I, Zweidler-McKay, PA, Estrov, Z, Zhao, ZJ, Verstovsek, S, Calin, GA, Redis, RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight 9(3), 2024. e-Pub 2024. PMID: 38329131.
- Figueroa M, Ma H, Alfayez M, Morales-Mantilla DE, Wang F, Lu Y, Estecio MR, King KY, Kleinerman ES, Moghaddam, SJ, Daver NG, Andreeff M, Konopleva MY, DiNardo CD, Chandra J. Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Adv 7(21):6624-6629, 2023. e-Pub 2023. PMID: 37486624.
- Zhao M, DiPeri TP, Raso MG, Zheng X, Rizvi YQ, Evans KW, Yang F, Akcakanat A, Estecio MR, Tripathy D, Dumbrava EE, Damodaran S, Meric-Bernstam F. Epigenetically upregulating TROP2 and SLFN11 enhances therapeutic efficacy of TROP2 antibody drug conjugate sacitizumab govitecan. NPJ Breast Cancer 9(1):66, 2023. e-Pub 2023. PMID: 37567892.
- Chen, Q, Liu, B, Zeng, Y, Hwang, JW, Dai, N, Corrêa, IR, Estecio, MR, Zhang, X, Albuquerque Almeida Santos, M, Chen, T, Cheng, X. GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer 5(2), 2023. e-Pub 2023. PMID: 37206360.
- Simper, M, Coletta, LD, Gaddis, S, Lin, H, Mikulec, C, Takata, Y, Tomida, MW, Zhang, D, Tang, DG, Estecio, MR, Shen, J, Lu, Y. Commercial ChIP-Seq Library Preparation Kits Performed Dierently for Dierent Classes of Protein Targets. J Biomol Tech 33(3), 2022. e-Pub 2022. PMID: 36910579.
- Darbaniyan F, Zheng H, Kanagal-Shamanna R, Lockyer P, Montalban-Bravo G, Estecio M, Lu Y, Soltysiak KA, Chien KS, Yang H, Sasaki K, Class C, Ganan-Gomez I, Do KA, Garcia-Manero G, Wei Y. Transcriptomic Signatures of Hypomethylating Agent Failure in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Exp Hematol 115:44-53, 2022. e-Pub 2022. PMID: 36150563.
- Soundararajan R, Viscuse P, Pilie P, Liu J, Logotheti S, Laberiano Fernández C, Lorenzini D, Hoang A, Lu W, Soto LMS, Wistuba II, Xu M, Song X, Shepherd PDA, Navone NM, Tidwell RSS, Lozano G, Logothetis C, Zhang J, Long JP, Estecio MR, Tzelepi V, Aparicio AM. Genotype-to-Phenotype Associations in the Aggressive Variant Prostate Cancer Molecular Profile (AVPC-m) Components. Cancers (Basel) 14(14):3233, 2022. e-Pub 2022. PMID: 35805010.
- Morales F, Corrales E, Zhang B, Vásquez M, Santamaría-Ulloa C, Quesada H, Sirito M, Estecio MR, Monckton DG, Krahe R. Myotonic dystrophy type 1 (DM1) clinical sub-types and CTCF site methylation status flanking the CTG expansion are mutant allele length-dependent. Hum Mol Genet 31(2):262-274, 2021. e-Pub 2021. PMID: 34432028.
- Johnson KC, Anderson KJ, Courtois ET, Gujar AD, Barthel FP, Varn FS, Luo D, Seignon M, Yi E, Kim H, Estecio MRH, Zhao D, Tang M, Navin NE, Maurya R, Ngan CY, Verburg N, de Witt Hamer PC, Bulsara K, Samuels ML, Das S, Robson P, Verhaak RGW. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response. Nat Genet 53(10):1456-1468, 2021. e-Pub 2021. PMID: 34594038.
- Dejima H, Hu X, Chen R, Zhang J, Fujimoto J, Parra ER, Haymaker C, Hubert SM, Duose D, Solis LM, Su D, Fukuoka J, Tabata K, Pham HHN, Mcgranahan N, Zhang B, Ye J, Ying L, Little L, Gumbs C, Chow CW, Estecio MR, Godoy MCB, Antonoff MB, Sepesi B, Pass HI, Behrens C, Zhang J, Vaporciyan AA, Heymach JV, Scheet P, Lee JJ, Wu J, Futreal PA, Reuben A, Kadara H, Wistuba II, Zhang J. Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features. Nat Commun 12(1):2722, 2021. e-Pub 2021. PMID: 33976164.
- DiNardo CD, Beird HC, Estecio M, Hardikar S, Takahashi K, Bannon SA, Borthakur G, Jabbour E, Gumbs C, Khoury JD, Routbort M, Gong T, Kondo K, Kantarjian H, Garcia-Manero G, Chen T, Futreal PA. Germline DNMT3A mutation in familial acute myeloid leukaemia. Epigenetics 16(5):1-10, 2021. e-Pub 2021. PMID: 32856987.
- Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J. Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas. Nat Commun 12(1):687, 2021. e-Pub 2021. PMID: 33514726.
- Cortez MA, Masrorpour F, Ivan C, Zhang J, Younes AI, Lu Y, Estecio MR, Barsoumian HB, Menon H, Caetano MDS, Ramapriyan R, Schoenhals JE, Wang X, Skoulidis F, Wasley MD, Calin G, Hwu P, Welsh JW. Bone morphogenetic protein 7 promotes resistance to immunotherapy. Nat Commun 11(1):4840, 2020. e-Pub 2020. PMID: 32973129.
- Morales F, Vásquez M, Corrales E, Vindas-Smith R, Santamaría-Ulloa C, Zhang B, Sirito M, Estecio MR, Krahe R, Monckton DG. Longitudinal increases in somatic mosaicism of the expanded CTG repeat in myotonic dystrophy type 1 are associated with variation in age-at-onset. Hum Mol Genet 29(15):2496-2507, 2020. e-Pub 2020. PMID: 32601694.
- Herrera-Merchan A, Cuadros M, Rodriguez MI, Rodriguez S, Torres R, Estecio M, Coira IF, Loidi C, Saiz M, Carmona-Saez P, Medina PP. The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma. Oncotarget 11(13):1172-1185, 2020. e-Pub 2020. PMID: 32284793.
- Fuentes-Mattei E, Bayraktar R, Manshouri T, Silva AM, Ivan C, Gulei D, Fabris L, Soares do Amaral N, Mur P, Perez C, Torres-Claudio E, Dragomir MP, Badillo-Perez A, Knutsen E, Narayanan P, Golfman L, Shimizu M, Zhang X, Zhao W, Ho WT, Estecio MR, Bartholomeusz G, Tomuleasa C, Berindan-Neagoe I, Zweidler-McKay PA, Estrov Z, Zhao ZJ, Verstovsek S, Calin GA, Redis RS. miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2. JCI Insight 5(1), 2020. e-Pub 2020. PMID: 31941838.
- Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N. DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis 40(11):1332-1340, 2019. e-Pub 2019. PMID: 31284295.
- Veland N, Lu Y, Hardikar S, Gaddis S, Zeng Y, Liu B, Estecio MR, Takata Y, Lin K, Tomida MW, Shen J, Saha D, Gowher H, Zhao H, Chen T. DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells. Nucleic Acids Res 47(1):152-167, 2019. e-Pub 2019. PMID: 30321403.
- Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA. DNMT3A and TET1 Cooperate to Regulate Promoter Epigenetic Landscapes in Mouse Embryonic Stem Cells. Genome Biol 19(1):88, 2018. e-Pub 2018. PMID: 30001199.
- Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res 28(4):432-447, 2018. e-Pub 2018. PMID: 29567676.
- Rossi EL, Dunlap SM, Bowers LW, Khatib SA, Doerstling SS, Smith LA, Ford NA, Holley D, Brown PH, Estecio MR, Kusewitt DF, deGraffenried LA, Bultman SJ, Hursting SD. Energy balance modulation impacts epigenetic reprogramming, ERα and ERβ expression and mammary tumor development in MMTV-neu transgenic mice. Cancer Res 77(9):2500-2511, 2017. e-Pub 2017. PMID: 28373182.
- Quek K, Li J, Estecio M, Zhang J, Fujimoto J, Roarty E, Little L, Chow CW, Song X, Behrens C, Chen T, William WN, Swisher S, Heymach J, Wistuba I, Zhang J, Futreal A, Zhang J. DNA methylation intratumor heterogeneity in localized lung adenocarcinomas. Oncotarget 8(13):21994-22002, 2017. e-Pub 2017. PMID: 28423542.
- Long Y, Tsai WB, Chang JT, Estecio M, Wangpaichitr M, Savaraj N, Feun LG, Chen HH, Kuo MT. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget 7(50):82658-82670, 2016. e-Pub 2016. PMID: 27765932.
- Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep 16(1):133-47, 2016. e-Pub 2016. PMID: 27320920.
- Rossi EL, de Angel RE, Bowers LW, Khatib SA, Smith LA, Van Buren E, Bhardwaj P, Giri D, Estecio MR, Troester MA, Hair BY, Kirk EL, Gong T, Shen J, Dannenberg AJ, Hursting SD. Obesity-Associated Alterations in Inflammation, Epigenetics, and Mammary Tumor Growth Persist in Formerly Obese Mice. Cancer Prev Res (Phila) 9(5):339-48, 2016. e-Pub 2016. PMID: 26869351.
- Kleb B, Estécio MR, Zhang J, Tzelepi V, Chung W, Jelinek J, Navone NM, Tahir S, Marquez VE, Issa JP, Maity S, Aparicio A. Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas. Epigenetics 11(3):184-93, 2016. e-Pub 2016. PMID: 26890396.
- Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estécio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol 36(10):8147-58, 2015. e-Pub 2015. PMID: 25990457.
- Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estécio MR, Sahin AA, Aldaz CM. A Molecular Portrait Of High-Grade Ductal Carcinoma In Situ (DCIS). Cancer Res 75(18):3980-90, 2015. e-Pub 2015. PMID: 26249178.
- Rolyan H, Tyurina YY, Hernandez M, Amoscato AA, Sparvero LJ, Nmezi BC, Lu Y, Estécio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH, Dupree J, Bayir H, Kagan VE, Casaccia P, Padiath QS. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci 35(34):12002-17, 2015. e-Pub 2015. PMID: 26311780.
- Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estécio MR, Godley LA, Issa JP. TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res 75(14):2833-43, 2015. e-Pub 2015. PMID: 25972343.
- Yang H, Maddipoti S, Quesada A, Bohannan Z, Cabrero Calvo M, Colla S, Wei Y, Estécio MR, Wierda W, Bueso-Ramos C, Garcia-Manero G. Analysis of class I and II histone deacetylase gene expression in human leukemia. Leuk Lymphoma 56(12):3426-33, 2015. e-Pub 2015. PMID: 25944469.
- Estécio MR, Maddipoti S, Bueso-Ramos C, DiNardo CD, Yang H, Wei Y, Kondo K, Fang Z, Stevenson W, Chang KS, Pierce SA, Bohannan Z, Borthakur G, Kantarjian H, Garcia-Manero G. RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype. Br J Haematol 169(3):344-51, 2015. e-Pub 2015. PMID: 25612675.
- Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estécio MR, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell 27(5):644-57, 2015. e-Pub 2015. PMID: 25965571.
- Qin T, Si J, Raynal NJ, Wang X, Gharibyan V, Ahmed S, Hu X, Jin C, Lu Y, Shu J, Estécio MR, Jelinek J, Issa JP. Epigenetic synergy between decitabine and platinum derivatives. Clin Epigenetics 7(1):97, 2015. e-Pub 2015. PMID: 26366234.
- Xu Y, Zheng X, Yuan Y, Estécio MR, Issa JP, Qiu P, Ji Y, Liang S. BM-SNP: A Bayesian Model for SNP Calling Using High Throughput Sequencing Data. IEEE/ACM Trans Comput Biol Bioinform 11(6):1038-44, 2014. e-Pub 2014. PMID: 26357041.
- Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res 42(11):6956-71, 2014. e-Pub 2014. PMID: 24875481.
- Yang H, Bueso-Ramos C, DiNardo C, Estecio MR, Davanlou M, Geng QR, Fang Z, Nguyen M, Pierce S, Wei Y, Parmar S, Cortes J, Kantarjian H, Garcia-Manero G. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents. Leukemia 28(6):1280-8, 2014. e-Pub 2014. PMID: 24270737.
- Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP. Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res 24(4):580-91, 2014. e-Pub 2014. PMID: 24414704.
- Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, Shureiqi I, Toyota M, Kondo Y, Estecio MR, Issa JP. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res 74(5):1311-8, 2014. e-Pub 2014. PMID: 24385213.
- Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estécio MR. Colorectal Carcinomas with CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators. Gastroenterology 146(2):530-38.e5, 2014. e-Pub 2014. PMID: 24211491.
- Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estécio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol 14(12):R144, 2013. e-Pub 2013. PMID: 24367927.
- Tahara T, Maegawa S, Chung W, Garriga J, Jelinek J, Estecio MR, Shibata T, Hirata I, Arisawa T, Issa JP. Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. Cancer Prev Res (Phila) 6(10):1093-100, 2013. e-Pub 2013. PMID: 23943784.
- Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res 23(9):1446-61, 2013. e-Pub 2013. PMID: 23796952.
- Yamazaki J, Estécio MR, Lu Y, Long H, Malouf GG, Graber D, Huo Y, Ramagli L, Liang S, Kornblau SM, Jelinek J, Issa JP. The epigenome of AML stem and progenitor cells. Epigenetics 8(1):92-104, 2013. e-Pub 2013. PMID: 23249680.
- Jelinek J, Liang S, Lu Y, He R, Ramagli LS, Shpall EJ, Estécio MR, Issa JP. Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics 7(12):1368-78, 2012. e-Pub 2012. PMID: 23075513.
- Xu Y, Zheng X, Yuan Y, Estécio MR, Issa JP, Ji Y, Liang S. A Bayesian Model for SNP Discovery Based on Next-Generation Sequencing Data. IEEE Int Workshop Genomic Signal Process Stat 2012:42-45, 2012. e-Pub 2012. PMID: 26726304.
- Estécio MR, Gallegos J, Dekmezian M, Lu Y, Liang S, Issa JP. SINE Retrotransposons Cause Epigenetic Reprogramming of Adjacent Gene Promoters. Mol Cancer Res 10(10):1332-42, 2012. e-Pub 2012. PMID: 22952045.
- Zhang Y, Shu J, Si J, Shen L, Estécio MR, Issa JP. Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island. Nucleic Acids Res 40(15):7257-68, 2012. e-Pub 2012. PMID: 22600741.
- Raynal NJ, Si J, Taby RF, Gharibyan V, Ahmed S, Jelinek J, Estécio MR, Issa JP. DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res 72(5):1170-81, 2012. e-Pub 2012. PMID: 22219169.
- Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estécio MR, Jelinek J, Godley LA, Issa JP. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics 7(2):201-7, 2012. e-Pub 2012. PMID: 22395470.
- Jelinek J, Gharibyan V, Estécio MR, Kondo K, He R, Chung W, Lu Y, Zhang N, Liang S, Kantarjian HM, Cortes JE, Issa JP. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. PLoS One 6(7):e22110, 2011. e-Pub 2011. PMID: 21760961.
- Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estécio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One 6(11):e27889, 2011. e-Pub 2011. PMID: 22132162.
- Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estécio MR, Shen L, Jelinek J, Issa JP. Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer. PLoS One 6(8):e23320, 2011. e-Pub 2011. PMID: 21853109.
- Estécio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP. Genome Architecture Marked by Retrotransposons Modulates Predisposition to DNA Methylation in Cancer. Genome Res 20(10):1369-1382, 2010. e-Pub 2010. PMID: 20716667.
- Tellez CS, Shen L, Estécio MR, Jelinek J, Gershenwald JE, Issa JP. CpG island methylation profiling in human melanoma cell lines. Melanoma Res 19(3):146-55, 2009. e-Pub 2009. PMID: 19441164.
- Watanabe Y, Kim HS, Castoro RJ, Chung W, Estécio MR, Kondo K, Guo Y, Ahmed SS, Toyota M, Itoh F, Suk KT, Cho MY, Shen L, Jelinek J, Issa JP. Sensitive and Specific Detection of Early Gastric Cancer Using DNA Methylation Analysis of Gastric Washes. Gastroenterology 136(7):2149-58, 2009. e-Pub 2009. PMID: 19375421.
- Liang S, Lu Y, Jelinek J, Estécio MR, Li H, Issa JP. Analysis of epigenetic modifications by next generation sequencing. Conf Proc IEEE Eng Med Biol Soc 1:6730, 2009. e-Pub 2009. PMID: 19963934.
- Kroeger H, Jelinek J, Estécio MR, He R, Kondo K, Chung W, Zhang L, Shen L, Kantarjian HM, Bueso-Ramos CE, Issa JP. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 112(4):1366-73, 2008. e-Pub 2008. PMID: 18523155.
- Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Estécio MR, Ahmed S, Issa JP. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet 4(8):e1000162, 2008. e-Pub 2008. PMID: 18725933.
- Estecio MR, Yan PS, Ibrahim AE, Tellez CS, Shen L, Huang TH, Issa JP. High throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res 17(10):1529-1536, 2007. e-Pub 2007. PMID: 17785535.
- Choi IS, Estecio MR, Nagano Y, Kim do H, White JA, Yao JC, Issa JP, Rashid A. Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol 20(7):802-10, 2007. e-Pub 2007. PMID: 17483816.
- Estecio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE 2(5):399, 2007. e-Pub 2007. PMID: 17476321.
- Montero AJ, Díaz-Montero CM, Mao L, Youssef EM, Estécio MR, Shen L, Issa JP. Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer. Cancer Biol Ther 5(11):1494-501, 2006. e-Pub 2006. PMID: 17369752.
- Estecio MR, Youssef EM, Rahal P, Fukuyama EE, Gois-Filho JF, Maniglia JV, Goloni-Bertollo EM, Issa JP, Tajara EH. LHX6 is a sensitive methylation marker in head and neck carcinomas. Oncogene 25(36):5018-26, 2006. e-Pub 2006. PMID: 16732332.
- Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res 66(10):5495-503, 2006. e-Pub 2006. PMID: 16707479.
- Reis EM, Ojopi EP, Alberto FL, Rahal P, Tsukumo F, Mancini UM, Guimarães GS, Thompson GM, Camacho C, Miracca E, Carvalho AL, Machado AA, Paquola AC, Cerutti JM, da Silva AM, Pereira GG, Valentini SR, Nagai MA, Kowalski LP, Verjovski-Almeida S, Tajara EH, Dias-Neto E, Bengtson MH, Canevari RA, Carazzolle MF, Colin C, Costa FF, Costa MC, Estécio MR, Esteves LI, Federico MH, Guimarães PE, Hackel C, Kimura ET, Leoni SG, Maciel RM, Maistro S, Mangone FR, Massirer KB, Matsuo SE, Nobrega FG, Nóbrega MP, Nunes DN, Nunes F, Pandolfi JR, Pardini MI, Pasini FS, Peres T, Rainho CA, dos Reis PP, Rodrigus-Lisoni FC, Rogatto SR, dos Santos A, dos Santos PC, Sogayar MC, Zanelli CF, Zanelli CF. Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer. Cancer Res 65(5):1693-9, 2005. e-Pub 2005. PMID: 15753364.
- Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 32(3):38, 2004. e-Pub 2004. PMID: 14973332.
- Youssef EM, Estecio MR, Issa JP. Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer. Cancer Biol Ther 3(1):82-6, 2004. e-Pub 2004. PMID: 14726683.
- Yang AS, Estecio MR, Garcia-Manero G, Kantarjian HM, Issa JP. Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation". Science 302(5648):1153, 2003. e-Pub 2003. PMID: 14615517.
- Brentani H, Caballero OL, Camargo AA, da Silva AM, da Silva WA, Dias Neto E, Grivet M, Gruber A, Guimaraes PE, Hide W, Iseli C, Jongeneel CV, Kelso J, Nagai MA, Ojopi EP, Osorio EC, Reis EM, Riggins GJ, Simpson AJ, de Souza S, Stevenson BJ, Strausberg RL, Tajara EH, Verjovski-Almeida S, Acencio ML, Bengtson MH, Bettoni F, Bodmer WF, Briones MR, Camargo LP, Cavenee W, Cerutti JM, Coelho Andrade LE, Costa dos Santos PC, Ramos Costa MC, da Silva IT, Estecio MR, Sa Ferreira K, Furnari FB, Faria M, Galante PA, Guimaraes GS, Holanda AJ, Kimura ET, Leerkes MR, Lu X, Maciel RM, Martins EA, Massirer KB, Melo AS, Mestriner CA, Miracca EC, Miranda LL, Nobrega FG, Oliveira PS, Paquola AC, Pandolfi JR, Campos Pardini MI, Passetti F, Quackenbush J, Schnabel B, Sogayar MC, Souza JE, Valentini SR, Zaiats AC, Amaral EJ, Arnaldi LA, de Araújo AG, de Bessa SA, Bicknell DC, Ribeiro de Camaro ME, Carraro DM, Carrer H, Carvalho AF, Colin C, Costa F, Curcio C, Guerreiro da Silva ID, Pereira da Silva N, Dellamano M, El-Dorry H, Espreafico EM, Scattone Ferreira AJ, Ayres Ferreira C, Fortes MA, Gama AH, Giannella-Neto D, Giannella ML, Giorgi RR, Goldman GH, Goldman MH, Hackel C, Ho PL, Kimura EM, Kowalski LP, Krieger JE, Leite LC, Lopes A, Luna AM, Mackay A, Mari SK, Marques AA, Martins WK, Montagnini A, Mourão Neto M, Nascimento AL, Neville AM, Nobrega MP, O'Hare MJ, Otsuka AY, Ruas de Melo AI, Paco-Larson ML, Guimarães Pereira G, Pereira da Silva N, Pesquero JB, Pessoa JG, Rahal P, Rainho CA, Rodrigues V, Rogatto SR, Romano CM, Romeiro JG, Rossi BM, Rusticci M, Guerra de Sá R, Sant' Anna SC, Sarmazo ML, Silva TC, Soares FA, Sonati Mde F, de Freitas Sousa J, Queiroz D, Valente V, Vettore AL, Villanova FE, Zago MA, Zalcberg H, Zalcberg H, Zalcberg H. The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A 23(23):13418-23, 2003. e-Pub 2003. PMID: 14593198.
- Estecio MR, Silva AE. [Chromosome abnormalities caused by computer video display monitors' radiation]. Rev Saude Publica 36(3):330-6, 2002. e-Pub 2002. PMID: 12131973.
- Estecio MR, Fett-Conte AC, Varella-Garcia M, Fridman C, Silva AE. Molecular and cytogenetic analyses on Brazilian youths with pervasive developmental disorders. J Autism Dev Disord 32(1):35-41, 2002. e-Pub 2002. PMID: 11916331.
- Estecio, MR, Fett-Conte, AC, Silva, AE. Relevância da genética na etiologia do autismo. Jornal Brasileiro de Psiquiatria 49(7):239-246, 2000. e-Pub 2000.
Invited Articles
- Gladych M, Andrzejewska A, Oleksiewicz U, Estécio MR. Epigenetic mechanisms of induced pluripotency. Contemp Oncol (Pozn) 19(1A):A30-8, 2015. e-Pub 2015. PMID: 25691819.
- Estécio MR, Issa JP. Dissecting DNA hypermethylation in cancer. FEBS Lett 585(13):2078-86, 2011. e-Pub 2011. PMID: 21146531.
- Estécio MR, Issa JP. Tackling the methylome: recent methodological advances in genome-wide methylation profiling. Genome Med 1(11):106, 2009. e-Pub 2009. PMID: 19930617.
- Estécio MR, Yan PS, Huang TH, Issa JP. Methylated CpG island amplification and microarray (MCAM) for high-throughput analysis of DNA methylation. CSH Protoc 3(3):pdb.prot4974, 2008. e-Pub 2008. PMID: 21356790.
- Carareto CM, Estecio MR, Tajara EH. Transposable elements and human disease: from genomic instability to carcinogenesis. HB Cientifica 8:113-125, 2001. e-Pub 2001.
- Estecio MR, Fett-Conte AC, Silva AE. Relevance of genetics in autism etiology. Jornal Brasileiro de Psiquiatria 49:239-246, 2000. e-Pub 2000.
Review Articles
- Tu SM, Estecio MR, Lin SH, Zacharias NM. Stem Cell Theory of Cancer: Rude Awakening or Bad Dream from Cancer Dormancy?. Cancers (Basel) 14(3):655, 2022. e-Pub 2022. PMID: 35158923.
Other Articles
- Cortez, MA, Masrorpour, F, Ivan, C, Zhang, J, Younes, AI, Lu, Y, Estecio, MR, Barsoumian, H, Menon, H, da Silva Caetano, M, Ramapriyan, R, Schoenhals, JE, Wang, X, Skoulidis, F, Wasley, M, Calin, GA, Hwu, P, Welsh, J Author Correction. Nature communications 11(1), 2020. PMID: 33033261.
Letters to the Editor
- Mancini UM, Estécio MR, Góis JF, Fukuyama EE, Valentim PJ, Cury PM, Bertollo EM, Tajara EH. The chromosome 5q21 band minisatellite and head and neck cancer. Cancer Genet Cytogenet 147: 87-8, 2003.
Patents
- Global DNA methylation assessment using bisulfite PCR. Patent Number: 20060019270.
Patient Reviews
CV information above last modified August 12, 2026